-- dump date 20140619_120457 -- class Genbank::misc_feature -- table misc_feature_note -- id note 759362000001 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 759362000002 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 759362000003 Walker A/P-loop; other site 759362000004 ATP binding site [chemical binding]; other site 759362000005 Q-loop/lid; other site 759362000006 ABC transporter signature motif; other site 759362000007 Walker B; other site 759362000008 D-loop; other site 759362000009 H-loop/switch region; other site 759362000010 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 759362000011 ABC-ATPase subunit interface; other site 759362000012 dimer interface [polypeptide binding]; other site 759362000013 putative PBP binding regions; other site 759362000014 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 759362000015 ABC-ATPase subunit interface; other site 759362000016 dimer interface [polypeptide binding]; other site 759362000017 putative PBP binding regions; other site 759362000018 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 759362000019 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 759362000020 siderophore binding site; other site 759362000021 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 759362000022 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 759362000023 siderophore binding site; other site 759362000024 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 759362000025 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 759362000026 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 759362000027 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759362000028 Major Facilitator Superfamily; Region: MFS_1; pfam07690 759362000029 putative substrate translocation pore; other site 759362000030 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 759362000031 Uncharacterized conserved protein [Function unknown]; Region: COG4544 759362000032 DNA Polymerase Y-family; Region: PolY_like; cd03468 759362000033 active site 759362000034 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 759362000035 DNA binding site [nucleotide binding] 759362000036 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 759362000037 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 759362000038 putative active site [active] 759362000039 putative PHP Thumb interface [polypeptide binding]; other site 759362000040 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 759362000041 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 759362000042 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 759362000043 generic binding surface II; other site 759362000044 generic binding surface I; other site 759362000045 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 759362000046 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 759362000047 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 759362000048 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 759362000049 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 759362000050 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 759362000051 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 759362000052 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 759362000053 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 759362000054 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 759362000055 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 759362000056 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 759362000057 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 759362000058 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 759362000059 Transcriptional regulators [Transcription]; Region: PurR; COG1609 759362000060 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 759362000061 DNA binding site [nucleotide binding] 759362000062 domain linker motif; other site 759362000063 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 759362000064 dimerization interface [polypeptide binding]; other site 759362000065 ligand binding site [chemical binding]; other site 759362000066 Predicted membrane protein [Function unknown]; Region: COG2259 759362000067 GTP-binding protein YchF; Reviewed; Region: PRK09601 759362000068 YchF GTPase; Region: YchF; cd01900 759362000069 G1 box; other site 759362000070 GTP/Mg2+ binding site [chemical binding]; other site 759362000071 Switch I region; other site 759362000072 G2 box; other site 759362000073 Switch II region; other site 759362000074 G3 box; other site 759362000075 G4 box; other site 759362000076 G5 box; other site 759362000077 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 759362000078 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 759362000079 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 759362000080 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 759362000081 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 759362000082 Ligand Binding Site [chemical binding]; other site 759362000083 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 759362000084 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 759362000085 ligand binding site [chemical binding]; other site 759362000086 flexible hinge region; other site 759362000087 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 759362000088 putative switch regulator; other site 759362000089 non-specific DNA interactions [nucleotide binding]; other site 759362000090 DNA binding site [nucleotide binding] 759362000091 sequence specific DNA binding site [nucleotide binding]; other site 759362000092 putative cAMP binding site [chemical binding]; other site 759362000093 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 759362000094 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 759362000095 FeS/SAM binding site; other site 759362000096 HemN C-terminal domain; Region: HemN_C; pfam06969 759362000097 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759362000098 putative substrate translocation pore; other site 759362000099 Major Facilitator Superfamily; Region: MFS_1; pfam07690 759362000100 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 759362000101 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 759362000102 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 759362000103 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 759362000104 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 759362000105 active site clefts [active] 759362000106 zinc binding site [ion binding]; other site 759362000107 dimer interface [polypeptide binding]; other site 759362000108 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 759362000109 interface (dimer of trimers) [polypeptide binding]; other site 759362000110 Substrate-binding/catalytic site; other site 759362000111 Zn-binding sites [ion binding]; other site 759362000112 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 759362000113 NlpC/P60 family; Region: NLPC_P60; cl17555 759362000114 Protein of unknown function (DUF2794); Region: DUF2794; pfam10984 759362000115 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 759362000116 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 759362000117 diiron binding motif [ion binding]; other site 759362000118 CCC1-related protein family; Region: CCC1_like_1; cd02437 759362000119 Predicted permeases [General function prediction only]; Region: COG0679 759362000120 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 759362000121 Predicted ATPase [General function prediction only]; Region: COG1485 759362000122 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 759362000123 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 759362000124 active site 759362000125 metal binding site [ion binding]; metal-binding site 759362000126 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 759362000127 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 759362000128 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 759362000129 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 759362000130 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 759362000131 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 759362000132 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 759362000133 putative active site [active] 759362000134 catalytic site [active] 759362000135 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 759362000136 putative active site [active] 759362000137 catalytic site [active] 759362000138 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 759362000139 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 759362000140 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 759362000141 putative MPT binding site; other site 759362000142 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 759362000143 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 759362000144 Coenzyme A binding pocket [chemical binding]; other site 759362000145 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 759362000146 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 759362000147 ligand binding site [chemical binding]; other site 759362000148 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759362000149 S-adenosylmethionine binding site [chemical binding]; other site 759362000150 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 759362000151 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 759362000152 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 759362000153 Reductase C-terminal; Region: Reductase_C; pfam14759 759362000154 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 759362000155 catalytic triad [active] 759362000156 dimer interface [polypeptide binding]; other site 759362000157 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 759362000158 aromatic arch; other site 759362000159 DCoH dimer interaction site [polypeptide binding]; other site 759362000160 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 759362000161 DCoH tetramer interaction site [polypeptide binding]; other site 759362000162 substrate binding site [chemical binding]; other site 759362000163 Protein of unknown function, DUF482; Region: DUF482; pfam04339 759362000164 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 759362000165 homotrimer interaction site [polypeptide binding]; other site 759362000166 putative active site [active] 759362000167 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 759362000168 HlyD family secretion protein; Region: HlyD_3; pfam13437 759362000169 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 759362000170 Walker A/P-loop; other site 759362000171 ATP binding site [chemical binding]; other site 759362000172 Q-loop/lid; other site 759362000173 ABC transporter signature motif; other site 759362000174 Walker B; other site 759362000175 D-loop; other site 759362000176 H-loop/switch region; other site 759362000177 type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842 759362000178 Transglycosylase; Region: Transgly; pfam00912 759362000179 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 759362000180 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 759362000181 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 759362000182 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 759362000183 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 759362000184 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759362000185 homodimer interface [polypeptide binding]; other site 759362000186 catalytic residue [active] 759362000187 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 759362000188 SmpB-tmRNA interface; other site 759362000189 Cytochrome c; Region: Cytochrom_C; cl11414 759362000190 TspO/MBR family; Region: TspO_MBR; pfam03073 759362000191 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 759362000192 active site 759362000193 dimer interface [polypeptide binding]; other site 759362000194 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 759362000195 nudix motif; other site 759362000196 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 759362000197 dimer interface [polypeptide binding]; other site 759362000198 active site 759362000199 catalytic residue [active] 759362000200 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 759362000201 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 759362000202 N-acetyl-D-glucosamine binding site [chemical binding]; other site 759362000203 catalytic residue [active] 759362000204 Predicted transcriptional regulator [Transcription]; Region: COG1959 759362000205 Rrf2 family protein; Region: rrf2_super; TIGR00738 759362000206 Transcriptional regulators [Transcription]; Region: PurR; COG1609 759362000207 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 759362000208 DNA binding site [nucleotide binding] 759362000209 domain linker motif; other site 759362000210 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 759362000211 dimerization interface [polypeptide binding]; other site 759362000212 ligand binding site [chemical binding]; other site 759362000213 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 759362000214 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 759362000215 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362000216 conserved gate region; other site 759362000217 putative PBP binding loops; other site 759362000218 ABC-ATPase subunit interface; other site 759362000219 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 759362000220 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362000221 dimer interface [polypeptide binding]; other site 759362000222 conserved gate region; other site 759362000223 putative PBP binding loops; other site 759362000224 ABC-ATPase subunit interface; other site 759362000225 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 759362000226 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 759362000227 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 759362000228 Walker A/P-loop; other site 759362000229 ATP binding site [chemical binding]; other site 759362000230 Q-loop/lid; other site 759362000231 ABC transporter signature motif; other site 759362000232 Walker B; other site 759362000233 D-loop; other site 759362000234 H-loop/switch region; other site 759362000235 TOBE domain; Region: TOBE_2; pfam08402 759362000236 Cytochrome c; Region: Cytochrom_C; pfam00034 759362000237 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 759362000238 Cytochrome c; Region: Cytochrom_C; pfam00034 759362000239 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 759362000240 DNA binding site [nucleotide binding] 759362000241 domain linker motif; other site 759362000242 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 759362000243 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 759362000244 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 759362000245 putative metal binding site [ion binding]; other site 759362000246 putative homodimer interface [polypeptide binding]; other site 759362000247 putative homotetramer interface [polypeptide binding]; other site 759362000248 putative homodimer-homodimer interface [polypeptide binding]; other site 759362000249 putative allosteric switch controlling residues; other site 759362000250 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 759362000251 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 759362000252 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 759362000253 putative DNA binding site [nucleotide binding]; other site 759362000254 putative Zn2+ binding site [ion binding]; other site 759362000255 AsnC family; Region: AsnC_trans_reg; pfam01037 759362000256 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 759362000257 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 759362000258 catalytic residue [active] 759362000259 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 759362000260 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 759362000261 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 759362000262 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 759362000263 Circularly permuted ATP-grasp type 2; Region: CP_ATPgrasp_2; cl17448 759362000264 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 759362000265 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 759362000266 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 759362000267 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 759362000268 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 759362000269 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 759362000270 HlyD family secretion protein; Region: HlyD_3; pfam13437 759362000271 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 759362000272 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 759362000273 HlyD family secretion protein; Region: HlyD_3; pfam13437 759362000274 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759362000275 Major Facilitator Superfamily; Region: MFS_1; pfam07690 759362000276 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 759362000277 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 759362000278 active site 759362000279 catalytic tetrad [active] 759362000280 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 759362000281 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 759362000282 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 759362000283 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 759362000284 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 759362000285 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 759362000286 Walker A/P-loop; other site 759362000287 ATP binding site [chemical binding]; other site 759362000288 Q-loop/lid; other site 759362000289 ABC transporter signature motif; other site 759362000290 Walker B; other site 759362000291 D-loop; other site 759362000292 H-loop/switch region; other site 759362000293 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 759362000294 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362000295 dimer interface [polypeptide binding]; other site 759362000296 conserved gate region; other site 759362000297 putative PBP binding loops; other site 759362000298 ABC-ATPase subunit interface; other site 759362000299 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 759362000300 FAD binding site [chemical binding]; other site 759362000301 protoporphyrinogen oxidase; Region: PLN02576 759362000302 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 759362000303 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 759362000304 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 759362000305 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 759362000306 active site 759362000307 homodimer interface [polypeptide binding]; other site 759362000308 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 759362000309 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 759362000310 hinge; other site 759362000311 active site 759362000312 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759362000313 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 759362000314 Walker A/P-loop; other site 759362000315 ATP binding site [chemical binding]; other site 759362000316 Q-loop/lid; other site 759362000317 ABC transporter signature motif; other site 759362000318 Walker B; other site 759362000319 D-loop; other site 759362000320 H-loop/switch region; other site 759362000321 sulfate transport protein; Provisional; Region: cysT; CHL00187 759362000322 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362000323 dimer interface [polypeptide binding]; other site 759362000324 conserved gate region; other site 759362000325 putative PBP binding loops; other site 759362000326 ABC-ATPase subunit interface; other site 759362000327 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 759362000328 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362000329 dimer interface [polypeptide binding]; other site 759362000330 conserved gate region; other site 759362000331 putative PBP binding loops; other site 759362000332 ABC-ATPase subunit interface; other site 759362000333 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 759362000334 Glycerol-3-phosphate O-acyltransferase [Lipid metabolism]; Region: PlsB; COG2937 759362000335 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 759362000336 putative acyl-acceptor binding pocket; other site 759362000337 AAA domain; Region: AAA_30; pfam13604 759362000338 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 759362000339 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 759362000340 trimer interface [polypeptide binding]; other site 759362000341 active site 759362000342 dimer interface [polypeptide binding]; other site 759362000343 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 759362000344 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 759362000345 Walker A/P-loop; other site 759362000346 ATP binding site [chemical binding]; other site 759362000347 Q-loop/lid; other site 759362000348 ABC transporter signature motif; other site 759362000349 Walker B; other site 759362000350 D-loop; other site 759362000351 H-loop/switch region; other site 759362000352 ABC-2 type transporter; Region: ABC2_membrane; cl17235 759362000353 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 759362000354 short chain dehydrogenase; Provisional; Region: PRK09134 759362000355 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 759362000356 NAD(P) binding site [chemical binding]; other site 759362000357 active site 759362000358 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 759362000359 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 759362000360 GIY-YIG motif/motif A; other site 759362000361 active site 759362000362 catalytic site [active] 759362000363 putative DNA binding site [nucleotide binding]; other site 759362000364 metal binding site [ion binding]; metal-binding site 759362000365 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 759362000366 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 759362000367 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 759362000368 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 759362000369 MoaE interaction surface [polypeptide binding]; other site 759362000370 MoeB interaction surface [polypeptide binding]; other site 759362000371 thiocarboxylated glycine; other site 759362000372 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 759362000373 MoaE homodimer interface [polypeptide binding]; other site 759362000374 MoaD interaction [polypeptide binding]; other site 759362000375 active site residues [active] 759362000376 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 759362000377 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 759362000378 EamA-like transporter family; Region: EamA; pfam00892 759362000379 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 759362000380 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759362000381 S-adenosylmethionine binding site [chemical binding]; other site 759362000382 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 759362000383 substrate binding pocket [chemical binding]; other site 759362000384 chain length determination region; other site 759362000385 substrate-Mg2+ binding site; other site 759362000386 catalytic residues [active] 759362000387 aspartate-rich region 1; other site 759362000388 active site lid residues [active] 759362000389 aspartate-rich region 2; other site 759362000390 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 759362000391 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 759362000392 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 759362000393 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759362000394 TPR motif; other site 759362000395 binding surface 759362000396 TPR repeat; Region: TPR_11; pfam13414 759362000397 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759362000398 binding surface 759362000399 TPR motif; other site 759362000400 TPR repeat; Region: TPR_11; pfam13414 759362000401 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 759362000402 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 759362000403 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 759362000404 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 759362000405 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 759362000406 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 759362000407 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 759362000408 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 759362000409 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 759362000410 Coenzyme A binding pocket [chemical binding]; other site 759362000411 Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835 759362000412 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 759362000413 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 759362000414 hypothetical protein; Provisional; Region: PRK12705 759362000415 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 759362000416 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 759362000417 ligand binding site [chemical binding]; other site 759362000418 4-Hydroxybenzoate polyprenyltransferase; Region: PT_UbiA_COQ2; cd13959 759362000419 putative active site [active] 759362000420 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 759362000421 glutamate--cysteine ligase; Region: PLN02611 759362000422 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 759362000423 dihydroorotase; Validated; Region: PRK09059 759362000424 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 759362000425 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 759362000426 active site 759362000427 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 759362000428 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 759362000429 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 759362000430 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 759362000431 putative acyl-acceptor binding pocket; other site 759362000432 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 759362000433 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 759362000434 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 759362000435 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759362000436 Walker A/P-loop; other site 759362000437 ATP binding site [chemical binding]; other site 759362000438 Q-loop/lid; other site 759362000439 ABC transporter signature motif; other site 759362000440 Walker B; other site 759362000441 D-loop; other site 759362000442 H-loop/switch region; other site 759362000443 zinc-ribbon domain; Region: zinc_ribbon_4; pfam13717 759362000444 Cytochrome oxidase subunit II; Region: Cyto_ox_2; cl12219 759362000445 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 759362000446 diaminopimelate decarboxylase; Region: lysA; TIGR01048 759362000447 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 759362000448 active site 759362000449 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 759362000450 substrate binding site [chemical binding]; other site 759362000451 catalytic residues [active] 759362000452 dimer interface [polypeptide binding]; other site 759362000453 argininosuccinate lyase; Provisional; Region: PRK00855 759362000454 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 759362000455 active sites [active] 759362000456 tetramer interface [polypeptide binding]; other site 759362000457 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 759362000458 catalytic residues [active] 759362000459 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 759362000460 Putative transcriptional regulator [Transcription]; Region: COG1678 759362000461 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 759362000462 Recombination protein O N terminal; Region: RecO_N; pfam11967 759362000463 Recombination protein O C terminal; Region: RecO_C; pfam02565 759362000464 Protein of unknown function (DUF1491); Region: DUF1491; pfam07372 759362000465 GTPase Era; Reviewed; Region: era; PRK00089 759362000466 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 759362000467 G1 box; other site 759362000468 GTP/Mg2+ binding site [chemical binding]; other site 759362000469 Switch I region; other site 759362000470 G2 box; other site 759362000471 Switch II region; other site 759362000472 G3 box; other site 759362000473 G4 box; other site 759362000474 G5 box; other site 759362000475 KH domain; Region: KH_2; pfam07650 759362000476 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 759362000477 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 759362000478 dimerization interface [polypeptide binding]; other site 759362000479 active site 759362000480 metal binding site [ion binding]; metal-binding site 759362000481 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 759362000482 dsRNA binding site [nucleotide binding]; other site 759362000483 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 759362000484 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 759362000485 Catalytic site [active] 759362000486 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 759362000487 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 759362000488 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 759362000489 active site 759362000490 hydrophilic channel; other site 759362000491 dimerization interface [polypeptide binding]; other site 759362000492 catalytic residues [active] 759362000493 active site lid [active] 759362000494 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 759362000495 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 759362000496 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 759362000497 Zn2+ binding site [ion binding]; other site 759362000498 Mg2+ binding site [ion binding]; other site 759362000499 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 759362000500 synthetase active site [active] 759362000501 NTP binding site [chemical binding]; other site 759362000502 metal binding site [ion binding]; metal-binding site 759362000503 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 759362000504 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 759362000505 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 759362000506 Uncharacterized conserved protein [Function unknown]; Region: COG1432 759362000507 LabA_like proteins; Region: LabA; cd10911 759362000508 putative metal binding site [ion binding]; other site 759362000509 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 759362000510 Fe-S cluster binding site [ion binding]; other site 759362000511 substrate binding site [chemical binding]; other site 759362000512 catalytic site [active] 759362000513 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 759362000514 RNA/DNA hybrid binding site [nucleotide binding]; other site 759362000515 active site 759362000516 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 759362000517 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 759362000518 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 759362000519 putative active site [active] 759362000520 putative substrate binding site [chemical binding]; other site 759362000521 putative cosubstrate binding site; other site 759362000522 catalytic site [active] 759362000523 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 759362000524 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 759362000525 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 759362000526 putative active site [active] 759362000527 substrate binding site [chemical binding]; other site 759362000528 putative cosubstrate binding site; other site 759362000529 catalytic site [active] 759362000530 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 759362000531 substrate binding site [chemical binding]; other site 759362000532 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 759362000533 active site 759362000534 catalytic residues [active] 759362000535 metal binding site [ion binding]; metal-binding site 759362000536 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 759362000537 active site 759362000538 catalytic residues [active] 759362000539 metal binding site [ion binding]; metal-binding site 759362000540 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 759362000541 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 759362000542 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759362000543 homodimer interface [polypeptide binding]; other site 759362000544 catalytic residue [active] 759362000545 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 759362000546 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 759362000547 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 759362000548 putative dimer interface [polypeptide binding]; other site 759362000549 N-terminal domain interface [polypeptide binding]; other site 759362000550 putative substrate binding pocket (H-site) [chemical binding]; other site 759362000551 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 759362000552 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 759362000553 active site 759362000554 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 759362000555 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 759362000556 Walker A/P-loop; other site 759362000557 ATP binding site [chemical binding]; other site 759362000558 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 759362000559 ABC transporter signature motif; other site 759362000560 Walker B; other site 759362000561 D-loop; other site 759362000562 H-loop/switch region; other site 759362000563 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 759362000564 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 759362000565 Coenzyme A binding pocket [chemical binding]; other site 759362000566 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 759362000567 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 759362000568 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 759362000569 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 759362000570 EamA-like transporter family; Region: EamA; pfam00892 759362000571 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 759362000572 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 759362000573 DctM-like transporters; Region: DctM; pfam06808 759362000574 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 759362000575 Archaeal/vacuolar-type H+-ATPase subunit I [Energy production and conversion]; Region: NtpI; COG1269 759362000576 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 759362000577 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Low Specificity D-Threonine Aldolase; Region: PLPDE_III_LS_D-TA; cd06819 759362000578 dimer interface [polypeptide binding]; other site 759362000579 active site 759362000580 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 759362000581 substrate binding site [chemical binding]; other site 759362000582 catalytic residue [active] 759362000583 Transcriptional regulators [Transcription]; Region: GntR; COG1802 759362000584 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 759362000585 DNA-binding site [nucleotide binding]; DNA binding site 759362000586 FCD domain; Region: FCD; pfam07729 759362000587 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 759362000588 DNA binding residues [nucleotide binding] 759362000589 mercuric resistence transcriptional repressor protein MerD; Region: MerD; TIGR02054 759362000590 dimer interface [polypeptide binding]; other site 759362000591 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 759362000592 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 759362000593 active site 759362000594 catalytic tetrad [active] 759362000595 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 759362000596 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 759362000597 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 759362000598 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 759362000599 NAD(P) binding site [chemical binding]; other site 759362000600 active site 759362000601 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 759362000602 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 759362000603 putative NAD(P) binding site [chemical binding]; other site 759362000604 putative active site [active] 759362000605 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 759362000606 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 759362000607 active site 759362000608 catalytic tetrad [active] 759362000609 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 759362000610 catalytic motif [active] 759362000611 Zn binding site [ion binding]; other site 759362000612 RibD C-terminal domain; Region: RibD_C; cl17279 759362000613 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 759362000614 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 759362000615 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 759362000616 dimerization interface [polypeptide binding]; other site 759362000617 active site 759362000618 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 759362000619 homopentamer interface [polypeptide binding]; other site 759362000620 active site 759362000621 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 759362000622 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 759362000623 catalytic residue [active] 759362000624 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 759362000625 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 759362000626 Trp docking motif [polypeptide binding]; other site 759362000627 active site 759362000628 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 759362000629 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 759362000630 active site 759362000631 catalytic tetrad [active] 759362000632 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 759362000633 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 759362000634 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 759362000635 Predicted transcriptional regulator [Transcription]; Region: COG1959 759362000636 Transcriptional regulators [Transcription]; Region: PurR; COG1609 759362000637 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 759362000638 DNA binding site [nucleotide binding] 759362000639 domain linker motif; other site 759362000640 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 759362000641 ligand binding site [chemical binding]; other site 759362000642 dimerization interface [polypeptide binding]; other site 759362000643 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 759362000644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362000645 dimer interface [polypeptide binding]; other site 759362000646 conserved gate region; other site 759362000647 putative PBP binding loops; other site 759362000648 ABC-ATPase subunit interface; other site 759362000649 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 759362000650 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759362000651 Walker A/P-loop; other site 759362000652 ATP binding site [chemical binding]; other site 759362000653 Q-loop/lid; other site 759362000654 ABC transporter signature motif; other site 759362000655 Walker B; other site 759362000656 D-loop; other site 759362000657 H-loop/switch region; other site 759362000658 TOBE domain; Region: TOBE_2; pfam08402 759362000659 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 759362000660 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362000661 dimer interface [polypeptide binding]; other site 759362000662 conserved gate region; other site 759362000663 putative PBP binding loops; other site 759362000664 ABC-ATPase subunit interface; other site 759362000665 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 759362000666 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 759362000667 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; cl08459 759362000668 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 759362000669 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 759362000670 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 759362000671 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 759362000672 intersubunit interface [polypeptide binding]; other site 759362000673 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl18951 759362000674 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 759362000675 FAD dependent oxidoreductase; Region: DAO; pfam01266 759362000676 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 759362000677 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 759362000678 homotrimer interaction site [polypeptide binding]; other site 759362000679 putative active site [active] 759362000680 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 759362000681 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362000682 Walker A/P-loop; other site 759362000683 ATP binding site [chemical binding]; other site 759362000684 Q-loop/lid; other site 759362000685 ABC transporter signature motif; other site 759362000686 Walker B; other site 759362000687 D-loop; other site 759362000688 H-loop/switch region; other site 759362000689 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362000690 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362000691 Walker A/P-loop; other site 759362000692 ATP binding site [chemical binding]; other site 759362000693 Q-loop/lid; other site 759362000694 ABC transporter signature motif; other site 759362000695 Walker B; other site 759362000696 D-loop; other site 759362000697 H-loop/switch region; other site 759362000698 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362000699 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 759362000700 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 759362000701 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362000702 dimer interface [polypeptide binding]; other site 759362000703 conserved gate region; other site 759362000704 putative PBP binding loops; other site 759362000705 ABC-ATPase subunit interface; other site 759362000706 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 759362000707 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362000708 dimer interface [polypeptide binding]; other site 759362000709 conserved gate region; other site 759362000710 putative PBP binding loops; other site 759362000711 ABC-ATPase subunit interface; other site 759362000712 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 759362000713 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 759362000714 transcriptional regulator NanR; Provisional; Region: PRK03837 759362000715 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 759362000716 DNA-binding site [nucleotide binding]; DNA binding site 759362000717 FCD domain; Region: FCD; pfam07729 759362000718 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 759362000719 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 759362000720 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 759362000721 Trp docking motif [polypeptide binding]; other site 759362000722 putative active site [active] 759362000723 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 759362000724 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 759362000725 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 759362000726 Cupredoxin superfamily; Region: Cupredoxin; cl19115 759362000727 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 759362000728 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 759362000729 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; cl12363 759362000730 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 759362000731 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 759362000732 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 759362000733 Putative lysophospholipase; Region: Hydrolase_4; cl19140 759362000734 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 759362000735 Predicted transcriptional regulator [Transcription]; Region: COG2378 759362000736 WYL domain; Region: WYL; pfam13280 759362000737 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 759362000738 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 759362000739 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 759362000740 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 759362000741 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 759362000742 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 759362000743 DNA binding residues [nucleotide binding] 759362000744 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 759362000745 Z1 domain; Region: Z1; pfam10593 759362000746 Domain of unknown function (DUF4420); Region: DUF4420; pfam14390 759362000747 AIPR protein; Region: AIPR; pfam10592 759362000748 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 759362000749 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 759362000750 active site 759362000751 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 759362000752 cofactor binding site; other site 759362000753 DNA binding site [nucleotide binding] 759362000754 substrate interaction site [chemical binding]; other site 759362000755 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 759362000756 additional DNA contacts [nucleotide binding]; other site 759362000757 mismatch recognition site; other site 759362000758 active site 759362000759 zinc binding site [ion binding]; other site 759362000760 DNA intercalation site [nucleotide binding]; other site 759362000761 Protein of unknown function (DUF2793); Region: DUF2793; pfam10983 759362000762 C1q domain; Region: C1q; cl17543 759362000763 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 759362000764 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 759362000765 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 759362000766 additional DNA contacts [nucleotide binding]; other site 759362000767 mismatch recognition site; other site 759362000768 active site 759362000769 zinc binding site [ion binding]; other site 759362000770 DNA intercalation site [nucleotide binding]; other site 759362000771 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 759362000772 cofactor binding site; other site 759362000773 DNA binding site [nucleotide binding] 759362000774 substrate interaction site [chemical binding]; other site 759362000775 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 759362000776 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 759362000777 DXD motif; other site 759362000778 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 759362000779 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 759362000780 NAD(P) binding site [chemical binding]; other site 759362000781 active site 759362000782 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759362000783 Major Facilitator Superfamily; Region: MFS_1; pfam07690 759362000784 putative substrate translocation pore; other site 759362000785 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 759362000786 RmuC family; Region: RmuC; pfam02646 759362000787 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759362000788 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 759362000789 Walker A/P-loop; other site 759362000790 ATP binding site [chemical binding]; other site 759362000791 Q-loop/lid; other site 759362000792 ABC transporter signature motif; other site 759362000793 Walker B; other site 759362000794 D-loop; other site 759362000795 H-loop/switch region; other site 759362000796 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 759362000797 ABC-ATPase subunit interface; other site 759362000798 dimer interface [polypeptide binding]; other site 759362000799 putative PBP binding regions; other site 759362000800 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 759362000801 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 759362000802 intersubunit interface [polypeptide binding]; other site 759362000803 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 759362000804 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 759362000805 N-terminal plug; other site 759362000806 ligand-binding site [chemical binding]; other site 759362000807 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 759362000808 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 759362000809 RNA binding site [nucleotide binding]; other site 759362000810 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 759362000811 RNA binding site [nucleotide binding]; other site 759362000812 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 759362000813 RNA binding site [nucleotide binding]; other site 759362000814 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 759362000815 RNA binding site [nucleotide binding]; other site 759362000816 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 759362000817 RNA binding site [nucleotide binding]; other site 759362000818 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 759362000819 RNA binding site [nucleotide binding]; other site 759362000820 Beta subunit of integration host factor (IHFB); Region: IHF_B; cd13836 759362000821 dimer interface [polypeptide binding]; other site 759362000822 DNA binding site [nucleotide binding] 759362000823 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 759362000824 active site 759362000825 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 759362000826 Coenzyme A binding pocket [chemical binding]; other site 759362000827 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 759362000828 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759362000829 catalytic residue [active] 759362000830 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 759362000831 putative active site [active] 759362000832 catalytic residue [active] 759362000833 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 759362000834 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 759362000835 CTC domain interface [polypeptide binding]; other site 759362000836 L16 interface [polypeptide binding]; other site 759362000837 Ribosomal protein TL5, C-terminal domain; Region: Ribosomal_TL5_C; pfam14693 759362000838 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 759362000839 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 759362000840 active site 759362000841 substrate binding site [chemical binding]; other site 759362000842 FMN binding site [chemical binding]; other site 759362000843 putative catalytic residues [active] 759362000844 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 759362000845 substrate binding site [chemical binding]; other site 759362000846 active site 759362000847 catalytic residues [active] 759362000848 heterodimer interface [polypeptide binding]; other site 759362000849 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 759362000850 Beta-lactamase; Region: Beta-lactamase; pfam00144 759362000851 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 759362000852 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362000853 Walker A/P-loop; other site 759362000854 ATP binding site [chemical binding]; other site 759362000855 Q-loop/lid; other site 759362000856 ABC transporter signature motif; other site 759362000857 Walker B; other site 759362000858 D-loop; other site 759362000859 H-loop/switch region; other site 759362000860 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362000861 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362000862 Walker A/P-loop; other site 759362000863 ATP binding site [chemical binding]; other site 759362000864 Q-loop/lid; other site 759362000865 ABC transporter signature motif; other site 759362000866 Walker B; other site 759362000867 D-loop; other site 759362000868 H-loop/switch region; other site 759362000869 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362000870 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 759362000871 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362000872 dimer interface [polypeptide binding]; other site 759362000873 conserved gate region; other site 759362000874 putative PBP binding loops; other site 759362000875 ABC-ATPase subunit interface; other site 759362000876 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 759362000877 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362000878 dimer interface [polypeptide binding]; other site 759362000879 conserved gate region; other site 759362000880 putative PBP binding loops; other site 759362000881 ABC-ATPase subunit interface; other site 759362000882 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 759362000883 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 759362000884 D-lactate dehydrogenase; Provisional; Region: PRK11183 759362000885 FAD binding domain; Region: FAD_binding_4; cl19922 759362000886 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 759362000887 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 759362000888 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 759362000889 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 759362000890 FeS/SAM binding site; other site 759362000891 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 759362000892 PhoH-like protein; Region: PhoH; pfam02562 759362000893 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 759362000894 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 759362000895 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 759362000896 Transporter associated domain; Region: CorC_HlyC; pfam03471 759362000897 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 759362000898 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 759362000899 putative active site [active] 759362000900 catalytic triad [active] 759362000901 putative dimer interface [polypeptide binding]; other site 759362000902 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 759362000903 S-adenosylmethionine synthetase; Validated; Region: PRK05250 759362000904 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 759362000905 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 759362000906 Bacterial SH3 domain; Region: SH3_3; pfam08239 759362000907 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 759362000908 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 759362000909 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 759362000910 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 759362000911 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 759362000912 catalytic triad [active] 759362000913 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 759362000914 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 759362000915 ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism]; Region: ArtM; COG4160 759362000916 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362000917 dimer interface [polypeptide binding]; other site 759362000918 conserved gate region; other site 759362000919 putative PBP binding loops; other site 759362000920 ABC-ATPase subunit interface; other site 759362000921 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 759362000922 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362000923 dimer interface [polypeptide binding]; other site 759362000924 conserved gate region; other site 759362000925 putative PBP binding loops; other site 759362000926 ABC-ATPase subunit interface; other site 759362000927 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 759362000928 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 759362000929 substrate binding pocket [chemical binding]; other site 759362000930 membrane-bound complex binding site; other site 759362000931 hinge residues; other site 759362000932 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 759362000933 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 759362000934 Walker A/P-loop; other site 759362000935 ATP binding site [chemical binding]; other site 759362000936 Q-loop/lid; other site 759362000937 ABC transporter signature motif; other site 759362000938 Walker B; other site 759362000939 D-loop; other site 759362000940 H-loop/switch region; other site 759362000941 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 759362000942 CTP synthetase; Validated; Region: pyrG; PRK05380 759362000943 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 759362000944 Catalytic site [active] 759362000945 active site 759362000946 UTP binding site [chemical binding]; other site 759362000947 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 759362000948 active site 759362000949 putative oxyanion hole; other site 759362000950 catalytic triad [active] 759362000951 protein translocase, SecG subunit; Region: secG; TIGR00810 759362000952 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 759362000953 GDP-binding site [chemical binding]; other site 759362000954 ACT binding site; other site 759362000955 IMP binding site; other site 759362000956 Thiamine pyrophosphokinase; Region: TPK; cd07995 759362000957 active site 759362000958 dimerization interface [polypeptide binding]; other site 759362000959 thiamine binding site [chemical binding]; other site 759362000960 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 759362000961 phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790 759362000962 ATP-grasp domain; Region: ATP-grasp_4; cl17255 759362000963 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 759362000964 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 759362000965 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 759362000966 generic binding surface II; other site 759362000967 generic binding surface I; other site 759362000968 Putative modulator of DNA gyrase; Region: PmbA_TldD; cl19356 759362000969 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 759362000970 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140 759362000971 Cupredoxin superfamily; Region: Cupredoxin; cl19115 759362000972 Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957 759362000973 putative active site [active] 759362000974 Cytochrome c oxidase assembly protein CtaG/Cox11; Region: CtaG_Cox11; pfam04442 759362000975 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 759362000976 Subunit III/VIIa interface [polypeptide binding]; other site 759362000977 Phospholipid binding site [chemical binding]; other site 759362000978 Subunit I/III interface [polypeptide binding]; other site 759362000979 Subunit III/VIb interface [polypeptide binding]; other site 759362000980 Subunit III/VIa interface; other site 759362000981 Subunit III/Vb interface [polypeptide binding]; other site 759362000982 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 759362000983 threonine synthase; Validated; Region: PRK09225 759362000984 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 759362000985 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759362000986 catalytic residue [active] 759362000987 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 759362000988 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 759362000989 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 759362000990 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 759362000991 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 759362000992 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 759362000993 FAD binding domain; Region: FAD_binding_4; pfam01565 759362000994 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 759362000995 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 759362000996 active site 759362000997 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 759362000998 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 759362000999 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 759362001000 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 759362001001 DNA binding residues [nucleotide binding] 759362001002 dimerization interface [polypeptide binding]; other site 759362001003 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 759362001004 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 759362001005 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 759362001006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362001007 dimer interface [polypeptide binding]; other site 759362001008 conserved gate region; other site 759362001009 putative PBP binding loops; other site 759362001010 ABC-ATPase subunit interface; other site 759362001011 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 759362001012 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 759362001013 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362001014 dimer interface [polypeptide binding]; other site 759362001015 conserved gate region; other site 759362001016 putative PBP binding loops; other site 759362001017 ABC-ATPase subunit interface; other site 759362001018 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362001019 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 759362001020 Walker A/P-loop; other site 759362001021 ATP binding site [chemical binding]; other site 759362001022 Q-loop/lid; other site 759362001023 ABC transporter signature motif; other site 759362001024 Walker B; other site 759362001025 D-loop; other site 759362001026 H-loop/switch region; other site 759362001027 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362001028 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 759362001029 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362001030 Walker A/P-loop; other site 759362001031 ATP binding site [chemical binding]; other site 759362001032 Q-loop/lid; other site 759362001033 ABC transporter signature motif; other site 759362001034 Walker B; other site 759362001035 D-loop; other site 759362001036 H-loop/switch region; other site 759362001037 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362001038 Uncharacterized conserved protein [Function unknown]; Region: COG3535 759362001039 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 759362001040 DNA-binding site [nucleotide binding]; DNA binding site 759362001041 RNA-binding motif; other site 759362001042 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 759362001043 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 759362001044 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 759362001045 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 759362001046 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 759362001047 active site 759362001048 dimer interface [polypeptide binding]; other site 759362001049 motif 1; other site 759362001050 motif 2; other site 759362001051 motif 3; other site 759362001052 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 759362001053 anticodon binding site; other site 759362001054 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 759362001055 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 759362001056 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 759362001057 methionine sulfoxide reductase A; Provisional; Region: PRK00058 759362001058 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 759362001059 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 759362001060 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 759362001061 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 759362001062 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 759362001063 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 759362001064 rod shape-determining protein MreC; Provisional; Region: PRK13922 759362001065 rod shape-determining protein MreB; Provisional; Region: PRK13927 759362001066 MreB and similar proteins; Region: MreB_like; cd10225 759362001067 nucleotide binding site [chemical binding]; other site 759362001068 Mg binding site [ion binding]; other site 759362001069 putative protofilament interaction site [polypeptide binding]; other site 759362001070 RodZ interaction site [polypeptide binding]; other site 759362001071 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 759362001072 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 759362001073 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 759362001074 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 759362001075 dimer interface [polypeptide binding]; other site 759362001076 active site 759362001077 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 759362001078 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 759362001079 active site 759362001080 histidinol-phosphatase; Region: hisB_Nterm; TIGR01261 759362001081 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 759362001082 active site 759362001083 motif I; other site 759362001084 motif II; other site 759362001085 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 759362001086 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 759362001087 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 759362001088 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 759362001089 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 759362001090 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 759362001091 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 759362001092 Probable Catalytic site; other site 759362001093 metal-binding site 759362001094 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 759362001095 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 759362001096 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 759362001097 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 759362001098 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 759362001099 RNA binding surface [nucleotide binding]; other site 759362001100 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 759362001101 active site 759362001102 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 759362001103 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 759362001104 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 759362001105 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 759362001106 DNA binding residues [nucleotide binding] 759362001107 hypothetical protein; Provisional; Region: PRK13687 759362001108 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 759362001109 ATP-binding site [chemical binding]; other site 759362001110 CoA-binding site [chemical binding]; other site 759362001111 Mg2+-binding site [ion binding]; other site 759362001112 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 759362001113 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 759362001114 active site 759362001115 Zn binding site [ion binding]; other site 759362001116 SCP-2 sterol transfer family; Region: SCP2; pfam02036 759362001117 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 759362001118 binding surface 759362001119 TPR repeat; Region: TPR_11; pfam13414 759362001120 TPR motif; other site 759362001121 Tetratricopeptide repeat; Region: TPR_16; pfam13432 759362001122 DEAD-like helicases superfamily; Region: DEXDc; smart00487 759362001123 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 759362001124 ATP binding site [chemical binding]; other site 759362001125 putative Mg++ binding site [ion binding]; other site 759362001126 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 759362001127 nucleotide binding region [chemical binding]; other site 759362001128 ATP-binding site [chemical binding]; other site 759362001129 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 759362001130 RNA binding surface [nucleotide binding]; other site 759362001131 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 759362001132 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 759362001133 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 759362001134 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 759362001135 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 759362001136 tetramer (dimer of dimers) interface [polypeptide binding]; other site 759362001137 active site 759362001138 dimer interface [polypeptide binding]; other site 759362001139 glutathione reductase; Validated; Region: PRK06116 759362001140 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 759362001141 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 759362001142 High frequency of lysogenization K (HflK) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflK; cd03404 759362001143 HflK protein; Region: hflK; TIGR01933 759362001144 HflC protein; Region: hflC; TIGR01932 759362001145 High frequency of lysogenization C (HflC) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflC; cd03405 759362001146 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 759362001147 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 759362001148 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 759362001149 protein binding site [polypeptide binding]; other site 759362001150 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 759362001151 protein binding site [polypeptide binding]; other site 759362001152 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 759362001153 catalytic loop [active] 759362001154 iron binding site [ion binding]; other site 759362001155 Protein of unknown function (DUF541); Region: SIMPL; cl01077 759362001156 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 759362001157 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 759362001158 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 759362001159 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 759362001160 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 759362001161 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 759362001162 G1 box; other site 759362001163 GTP/Mg2+ binding site [chemical binding]; other site 759362001164 G2 box; other site 759362001165 G3 box; other site 759362001166 Switch II region; other site 759362001167 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 759362001168 G1 box; other site 759362001169 GTP/Mg2+ binding site [chemical binding]; other site 759362001170 G2 box; other site 759362001171 Switch I region; other site 759362001172 G3 box; other site 759362001173 Switch II region; other site 759362001174 G4 box; other site 759362001175 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 759362001176 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 759362001177 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 759362001178 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 759362001179 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 759362001180 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 759362001181 dimer interface [polypeptide binding]; other site 759362001182 putative tRNA-binding site [nucleotide binding]; other site 759362001183 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 759362001184 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 759362001185 dimerization interface [polypeptide binding]; other site 759362001186 ligand binding site [chemical binding]; other site 759362001187 NADP binding site [chemical binding]; other site 759362001188 catalytic site [active] 759362001189 thymidine kinase; Provisional; Region: PRK04296 759362001190 Cytochrome c; Region: Cytochrom_C; cl11414 759362001191 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 759362001192 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 759362001193 Walker A/P-loop; other site 759362001194 ATP binding site [chemical binding]; other site 759362001195 Q-loop/lid; other site 759362001196 ABC transporter signature motif; other site 759362001197 Walker B; other site 759362001198 D-loop; other site 759362001199 H-loop/switch region; other site 759362001200 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 759362001201 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 759362001202 FtsX-like permease family; Region: FtsX; pfam02687 759362001203 prolyl-tRNA synthetase; Provisional; Region: PRK12325 759362001204 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 759362001205 dimer interface [polypeptide binding]; other site 759362001206 motif 1; other site 759362001207 active site 759362001208 motif 2; other site 759362001209 motif 3; other site 759362001210 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 759362001211 anticodon binding site; other site 759362001212 polyphosphate kinase; Provisional; Region: PRK05443 759362001213 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 759362001214 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 759362001215 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 759362001216 putative domain interface [polypeptide binding]; other site 759362001217 putative active site [active] 759362001218 catalytic site [active] 759362001219 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 759362001220 putative domain interface [polypeptide binding]; other site 759362001221 putative active site [active] 759362001222 catalytic site [active] 759362001223 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 759362001224 exopolyphosphatase; Region: exo_poly_only; TIGR03706 759362001225 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 759362001226 Ligand Binding Site [chemical binding]; other site 759362001227 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 759362001228 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 759362001229 active site 759362001230 HIGH motif; other site 759362001231 dimer interface [polypeptide binding]; other site 759362001232 KMSKS motif; other site 759362001233 Rhomboid family; Region: Rhomboid; cl11446 759362001234 Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; pfam09608 759362001235 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 759362001236 purine nucleoside phosphorylase; Provisional; Region: PRK08202 759362001237 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 759362001238 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 759362001239 TM-ABC transporter signature motif; other site 759362001240 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 759362001241 TM-ABC transporter signature motif; other site 759362001242 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 759362001243 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 759362001244 Walker A/P-loop; other site 759362001245 ATP binding site [chemical binding]; other site 759362001246 Q-loop/lid; other site 759362001247 ABC transporter signature motif; other site 759362001248 Walker B; other site 759362001249 D-loop; other site 759362001250 H-loop/switch region; other site 759362001251 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 759362001252 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 759362001253 ligand binding site [chemical binding]; other site 759362001254 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 759362001255 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 759362001256 Glycoprotease family; Region: Peptidase_M22; pfam00814 759362001257 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 759362001258 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 759362001259 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 759362001260 glutamyl-tRNA synthetase; Provisional; Region: PRK12558 759362001261 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 759362001262 active site 759362001263 nucleotide binding site [chemical binding]; other site 759362001264 HIGH motif; other site 759362001265 KMSKS motif; other site 759362001266 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 759362001267 DNA-binding site [nucleotide binding]; DNA binding site 759362001268 RNA-binding motif; other site 759362001269 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 759362001270 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 759362001271 ABC transporter; Region: ABC_tran_2; pfam12848 759362001272 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 759362001273 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 759362001274 active site 759362001275 KMSKS motif; other site 759362001276 tellurite resistance protein terB; Region: terB; cd07176 759362001277 putative metal binding site [ion binding]; other site 759362001278 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 759362001279 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 759362001280 active site 759362001281 nucleotide binding site [chemical binding]; other site 759362001282 HIGH motif; other site 759362001283 KMSKS motif; other site 759362001284 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 759362001285 UreD urease accessory protein; Region: UreD; pfam01774 759362001286 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 759362001287 alpha-gamma subunit interface [polypeptide binding]; other site 759362001288 beta-gamma subunit interface [polypeptide binding]; other site 759362001289 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 759362001290 gamma-beta subunit interface [polypeptide binding]; other site 759362001291 alpha-beta subunit interface [polypeptide binding]; other site 759362001292 urease subunit alpha; Reviewed; Region: ureC; PRK13207 759362001293 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 759362001294 subunit interactions [polypeptide binding]; other site 759362001295 active site 759362001296 flap region; other site 759362001297 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 759362001298 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 759362001299 dimer interface [polypeptide binding]; other site 759362001300 catalytic residues [active] 759362001301 UreF; Region: UreF; cl19817 759362001302 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 759362001303 2-keto-3-deoxy-galactonokinase; Region: DGOK; cl19846 759362001304 Transcriptional regulator [Transcription]; Region: LysR; COG0583 759362001305 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 759362001306 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 759362001307 putative effector binding pocket; other site 759362001308 dimerization interface [polypeptide binding]; other site 759362001309 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 759362001310 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 759362001311 putative metal binding site [ion binding]; other site 759362001312 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 759362001313 active site 759362001314 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 759362001315 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 759362001316 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 759362001317 putative dimer interface [polypeptide binding]; other site 759362001318 N-terminal domain interface [polypeptide binding]; other site 759362001319 putative substrate binding pocket (H-site) [chemical binding]; other site 759362001320 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 759362001321 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 759362001322 inhibitor-cofactor binding pocket; inhibition site 759362001323 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759362001324 catalytic residue [active] 759362001325 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 759362001326 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 759362001327 dimer interface [polypeptide binding]; other site 759362001328 active site 759362001329 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 759362001330 dimer interface [polypeptide binding]; other site 759362001331 active site 759362001332 recombination protein RecR; Reviewed; Region: recR; PRK00076 759362001333 RecR protein; Region: RecR; pfam02132 759362001334 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 759362001335 putative active site [active] 759362001336 putative metal-binding site [ion binding]; other site 759362001337 tetramer interface [polypeptide binding]; other site 759362001338 hypothetical protein; Validated; Region: PRK00153 759362001339 DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111 759362001340 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759362001341 Walker A motif; other site 759362001342 ATP binding site [chemical binding]; other site 759362001343 Walker B motif; other site 759362001344 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 759362001345 arginine finger; other site 759362001346 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 759362001347 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 759362001348 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 759362001349 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 759362001350 Coenzyme A binding pocket [chemical binding]; other site 759362001351 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 759362001352 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 759362001353 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 759362001354 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 759362001355 motif II; other site 759362001356 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 759362001357 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 759362001358 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 759362001359 hydrophobic ligand binding site; other site 759362001360 prephenate dehydratase; Provisional; Region: PRK11899 759362001361 Prephenate dehydratase; Region: PDT; pfam00800 759362001362 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 759362001363 putative L-Phe binding site [chemical binding]; other site 759362001364 Cytochrome c; Region: Cytochrom_C; cl11414 759362001365 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 759362001366 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 759362001367 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 759362001368 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362001369 dimer interface [polypeptide binding]; other site 759362001370 conserved gate region; other site 759362001371 putative PBP binding loops; other site 759362001372 ABC-ATPase subunit interface; other site 759362001373 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 759362001374 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 759362001375 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362001376 dimer interface [polypeptide binding]; other site 759362001377 conserved gate region; other site 759362001378 putative PBP binding loops; other site 759362001379 ABC-ATPase subunit interface; other site 759362001380 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 759362001381 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362001382 Walker A/P-loop; other site 759362001383 ATP binding site [chemical binding]; other site 759362001384 Q-loop/lid; other site 759362001385 ABC transporter signature motif; other site 759362001386 Walker B; other site 759362001387 D-loop; other site 759362001388 H-loop/switch region; other site 759362001389 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362001390 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362001391 Walker A/P-loop; other site 759362001392 ATP binding site [chemical binding]; other site 759362001393 Q-loop/lid; other site 759362001394 ABC transporter signature motif; other site 759362001395 Walker B; other site 759362001396 D-loop; other site 759362001397 H-loop/switch region; other site 759362001398 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 759362001399 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 759362001400 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 759362001401 HAD-hyrolase-like; Region: Hydrolase_like; cl19142 759362001402 Uncharacterized conserved protein [Function unknown]; Region: COG2127 759362001403 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 759362001404 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759362001405 S-adenosylmethionine binding site [chemical binding]; other site 759362001406 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 759362001407 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 759362001408 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 759362001409 domain interfaces; other site 759362001410 active site 759362001411 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 759362001412 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 759362001413 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759362001414 homodimer interface [polypeptide binding]; other site 759362001415 catalytic residue [active] 759362001416 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 759362001417 prephenate dehydrogenase; Validated; Region: PRK08507 759362001418 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 759362001419 Protein of unknown function, DUF606; Region: DUF606; cl01273 759362001420 Protein of unknown function, DUF606; Region: DUF606; cl01273 759362001421 hypothetical protein; Provisional; Region: PRK05208 759362001422 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 759362001423 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 759362001424 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 759362001425 RNA binding surface [nucleotide binding]; other site 759362001426 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759362001427 S-adenosylmethionine binding site [chemical binding]; other site 759362001428 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 759362001429 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759362001430 Walker A motif; other site 759362001431 ATP binding site [chemical binding]; other site 759362001432 Walker B motif; other site 759362001433 arginine finger; other site 759362001434 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759362001435 Walker A motif; other site 759362001436 ATP binding site [chemical binding]; other site 759362001437 Walker B motif; other site 759362001438 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 759362001439 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 759362001440 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759362001441 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 759362001442 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 759362001443 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 759362001444 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 759362001445 beta subunit interaction interface [polypeptide binding]; other site 759362001446 Walker A motif; other site 759362001447 ATP binding site [chemical binding]; other site 759362001448 Walker B motif; other site 759362001449 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 759362001450 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 759362001451 core domain interface [polypeptide binding]; other site 759362001452 delta subunit interface [polypeptide binding]; other site 759362001453 epsilon subunit interface [polypeptide binding]; other site 759362001454 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 759362001455 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 759362001456 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 759362001457 alpha subunit interaction interface [polypeptide binding]; other site 759362001458 Walker A motif; other site 759362001459 ATP binding site [chemical binding]; other site 759362001460 Walker B motif; other site 759362001461 inhibitor binding site; inhibition site 759362001462 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 759362001463 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13443 759362001464 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 759362001465 gamma subunit interface [polypeptide binding]; other site 759362001466 epsilon subunit interface [polypeptide binding]; other site 759362001467 LBP interface [polypeptide binding]; other site 759362001468 H-type lectin domain; Region: H_lectin; pfam09458 759362001469 hypothetical protein; Provisional; Region: PRK05170 759362001470 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 759362001471 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 759362001472 active site 759362001473 Riboflavin kinase; Region: Flavokinase; pfam01687 759362001474 HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4 759362001475 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 759362001476 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 759362001477 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 759362001478 DHH family; Region: DHH; pfam01368 759362001479 DHHA2 domain; Region: DHHA2; pfam02833 759362001480 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 759362001481 Zn binding site [ion binding]; other site 759362001482 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 759362001483 Zn binding site [ion binding]; other site 759362001484 Predicted esterase [General function prediction only]; Region: COG0400 759362001485 putative hydrolase; Provisional; Region: PRK11460 759362001486 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 759362001487 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 759362001488 Putative lysophospholipase; Region: Hydrolase_4; cl19140 759362001489 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 759362001490 Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481 759362001491 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 759362001492 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 759362001493 putative dimer interface [polypeptide binding]; other site 759362001494 Protein of unknown function (DUF1150); Region: DUF1150; pfam06620 759362001495 Protein of unknown function (DUF763); Region: DUF763; cl00620 759362001496 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 759362001497 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 759362001498 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 759362001499 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 759362001500 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 759362001501 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 759362001502 putative DNA binding site [nucleotide binding]; other site 759362001503 putative Zn2+ binding site [ion binding]; other site 759362001504 AsnC family; Region: AsnC_trans_reg; pfam01037 759362001505 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 759362001506 Uncharacterized conserved protein [Function unknown]; Region: COG1565 759362001507 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 759362001508 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 759362001509 Membrane fusogenic activity; Region: BMFP; pfam04380 759362001510 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 759362001511 metal binding site 2 [ion binding]; metal-binding site 759362001512 putative DNA binding helix; other site 759362001513 metal binding site 1 [ion binding]; metal-binding site 759362001514 dimer interface [polypeptide binding]; other site 759362001515 structural Zn2+ binding site [ion binding]; other site 759362001516 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 759362001517 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 759362001518 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 759362001519 ABC-ATPase subunit interface; other site 759362001520 dimer interface [polypeptide binding]; other site 759362001521 putative PBP binding regions; other site 759362001522 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 759362001523 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 759362001524 intersubunit interface [polypeptide binding]; other site 759362001525 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 759362001526 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 759362001527 active site 759362001528 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 759362001529 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 759362001530 Walker A/P-loop; other site 759362001531 ATP binding site [chemical binding]; other site 759362001532 Q-loop/lid; other site 759362001533 ABC transporter signature motif; other site 759362001534 Walker B; other site 759362001535 D-loop; other site 759362001536 H-loop/switch region; other site 759362001537 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 759362001538 putative ligand binding residues [chemical binding]; other site 759362001539 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 759362001540 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 759362001541 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 759362001542 Ferritin-like domain; Region: Ferritin; pfam00210 759362001543 heme binding site [chemical binding]; other site 759362001544 ferroxidase pore; other site 759362001545 ferroxidase diiron center [ion binding]; other site 759362001546 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 759362001547 TM-ABC transporter signature motif; other site 759362001548 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 759362001549 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 759362001550 Walker A/P-loop; other site 759362001551 ATP binding site [chemical binding]; other site 759362001552 Q-loop/lid; other site 759362001553 ABC transporter signature motif; other site 759362001554 Walker B; other site 759362001555 D-loop; other site 759362001556 H-loop/switch region; other site 759362001557 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 759362001558 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 759362001559 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 759362001560 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 759362001561 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 759362001562 nucleotide binding site [chemical binding]; other site 759362001563 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; pfam04115 759362001564 hypothetical protein; Provisional; Region: PRK11171 759362001565 Cupin domain; Region: Cupin_2; pfam07883 759362001566 Cupin domain; Region: Cupin_2; pfam07883 759362001567 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 759362001568 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 759362001569 active site 759362001570 catalytic site [active] 759362001571 tetramer interface [polypeptide binding]; other site 759362001572 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 759362001573 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 759362001574 active site 759362001575 homotetramer interface [polypeptide binding]; other site 759362001576 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 759362001577 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 759362001578 inhibitor-cofactor binding pocket; inhibition site 759362001579 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759362001580 catalytic residue [active] 759362001581 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 759362001582 metal-binding site [ion binding] 759362001583 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 759362001584 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 759362001585 metal-binding site [ion binding] 759362001586 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 759362001587 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 759362001588 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 759362001589 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 759362001590 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 759362001591 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 759362001592 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 759362001593 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 759362001594 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 759362001595 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12671 759362001596 SseB protein N-terminal domain; Region: SseB; pfam07179 759362001597 pyruvate phosphate dikinase; Provisional; Region: PRK09279 759362001598 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 759362001599 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 759362001600 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 759362001601 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 759362001602 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 759362001603 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 759362001604 active site 759362001605 substrate binding site [chemical binding]; other site 759362001606 metal binding site [ion binding]; metal-binding site 759362001607 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 759362001608 Coenzyme A binding pocket [chemical binding]; other site 759362001609 ketol-acid reductoisomerase; Provisional; Region: PRK05479 759362001610 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 759362001611 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 759362001612 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 759362001613 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 759362001614 putative DNA binding site [nucleotide binding]; other site 759362001615 putative Zn2+ binding site [ion binding]; other site 759362001616 AsnC family; Region: AsnC_trans_reg; pfam01037 759362001617 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 759362001618 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 759362001619 putative DNA binding site [nucleotide binding]; other site 759362001620 putative Zn2+ binding site [ion binding]; other site 759362001621 AsnC family; Region: AsnC_trans_reg; pfam01037 759362001622 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 759362001623 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 759362001624 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 759362001625 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 759362001626 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 759362001627 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 759362001628 DNA-binding site [nucleotide binding]; DNA binding site 759362001629 FCD domain; Region: FCD; pfam07729 759362001630 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 759362001631 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 759362001632 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 759362001633 active site 759362001634 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 759362001635 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 759362001636 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 759362001637 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 759362001638 catalytic site [active] 759362001639 subunit interface [polypeptide binding]; other site 759362001640 Yqey-like protein; Region: YqeY; cl17540 759362001641 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 759362001642 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 759362001643 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 759362001644 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 759362001645 allantoate amidohydrolase; Reviewed; Region: PRK12893 759362001646 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 759362001647 active site 759362001648 metal binding site [ion binding]; metal-binding site 759362001649 dimer interface [polypeptide binding]; other site 759362001650 phenylhydantoinase; Validated; Region: PRK08323 759362001651 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 759362001652 tetramer interface [polypeptide binding]; other site 759362001653 active site 759362001654 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 759362001655 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 759362001656 Walker A/P-loop; other site 759362001657 ATP binding site [chemical binding]; other site 759362001658 Q-loop/lid; other site 759362001659 ABC transporter signature motif; other site 759362001660 Walker B; other site 759362001661 D-loop; other site 759362001662 H-loop/switch region; other site 759362001663 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 759362001664 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362001665 dimer interface [polypeptide binding]; other site 759362001666 conserved gate region; other site 759362001667 putative PBP binding loops; other site 759362001668 ABC-ATPase subunit interface; other site 759362001669 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 759362001670 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 759362001671 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 759362001672 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 759362001673 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 759362001674 cytidylate kinase; Provisional; Region: cmk; PRK00023 759362001675 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 759362001676 CMP-binding site; other site 759362001677 The sites determining sugar specificity; other site 759362001678 Protein of unknown function (DUF1489); Region: DUF1489; pfam07370 759362001679 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 759362001680 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 759362001681 metal-binding site [ion binding] 759362001682 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 759362001683 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 759362001684 Soluble P-type ATPase [General function prediction only]; Region: COG4087 759362001685 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 759362001686 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 759362001687 DNA binding residues [nucleotide binding] 759362001688 dimer interface [polypeptide binding]; other site 759362001689 putative metal binding site [ion binding]; other site 759362001690 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 759362001691 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 759362001692 Walker A/P-loop; other site 759362001693 ATP binding site [chemical binding]; other site 759362001694 Q-loop/lid; other site 759362001695 ABC transporter signature motif; other site 759362001696 Walker B; other site 759362001697 D-loop; other site 759362001698 H-loop/switch region; other site 759362001699 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 759362001700 Protein of unknown function (DUF3816); Region: DUF3816; cl17272 759362001701 lytic murein transglycosylase; Region: MltB_2; TIGR02283 759362001702 Transglycosylase SLT domain; Region: SLT_2; pfam13406 759362001703 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 759362001704 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 759362001705 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 759362001706 active site 759362001707 HIGH motif; other site 759362001708 KMSKS motif; other site 759362001709 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 759362001710 tRNA binding surface [nucleotide binding]; other site 759362001711 anticodon binding site; other site 759362001712 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 759362001713 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 759362001714 active site 759362001715 catalytic tetrad [active] 759362001716 Protein of unknown function (DUF983); Region: DUF983; cl02211 759362001717 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 759362001718 EF-hand domain pair; Region: EF-hand_7; pfam13499 759362001719 Ca2+ binding site [ion binding]; other site 759362001720 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 759362001721 EF-hand domain pair; Region: EF-hand_7; pfam13499 759362001722 Ca2+ binding site [ion binding]; other site 759362001723 RNA polymerase sigma factor; Provisional; Region: PRK12524 759362001724 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 759362001725 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 759362001726 DNA binding residues [nucleotide binding] 759362001727 Heavy-metal resistance; Region: Metal_resist; pfam13801 759362001728 response regulator PleD; Reviewed; Region: pleD; PRK09581 759362001729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759362001730 active site 759362001731 phosphorylation site [posttranslational modification] 759362001732 ATP synthase delta (OSCP) subunit; Region: OSCP; cl17210 759362001733 dimerization interface [polypeptide binding]; other site 759362001734 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 759362001735 metal binding site [ion binding]; metal-binding site 759362001736 active site 759362001737 I-site; other site 759362001738 Protein of unknown function (DUF3572); Region: DUF3572; pfam12096 759362001739 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 759362001740 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 759362001741 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 759362001742 Intracellular septation protein A; Region: IspA; pfam04279 759362001743 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 759362001744 homodimer interface [polypeptide binding]; other site 759362001745 substrate-cofactor binding pocket; other site 759362001746 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759362001747 catalytic residue [active] 759362001748 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759362001749 putative substrate translocation pore; other site 759362001750 Transcriptional regulators [Transcription]; Region: PurR; COG1609 759362001751 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 759362001752 DNA binding site [nucleotide binding] 759362001753 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 759362001754 ligand binding site [chemical binding]; other site 759362001755 dimerization interface [polypeptide binding]; other site 759362001756 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759362001757 H+ Antiporter protein; Region: 2A0121; TIGR00900 759362001758 putative substrate translocation pore; other site 759362001759 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 759362001760 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 759362001761 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 759362001762 catalytic residue [active] 759362001763 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 759362001764 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 759362001765 Walker A/P-loop; other site 759362001766 ATP binding site [chemical binding]; other site 759362001767 Q-loop/lid; other site 759362001768 ABC transporter signature motif; other site 759362001769 Walker B; other site 759362001770 D-loop; other site 759362001771 H-loop/switch region; other site 759362001772 TOBE domain; Region: TOBE_2; pfam08402 759362001773 short chain dehydrogenase; Provisional; Region: PRK07074 759362001774 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 759362001775 NAD(P) binding site [chemical binding]; other site 759362001776 active site 759362001777 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 759362001778 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 759362001779 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 759362001780 homotrimer interaction site [polypeptide binding]; other site 759362001781 putative active site [active] 759362001782 dihydroorotase; Provisional; Region: PRK09237 759362001783 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 759362001784 active site 759362001785 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 759362001786 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 759362001787 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362001788 Walker A/P-loop; other site 759362001789 ATP binding site [chemical binding]; other site 759362001790 Q-loop/lid; other site 759362001791 ABC transporter signature motif; other site 759362001792 Walker B; other site 759362001793 D-loop; other site 759362001794 H-loop/switch region; other site 759362001795 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 759362001796 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362001797 Walker A/P-loop; other site 759362001798 ATP binding site [chemical binding]; other site 759362001799 Q-loop/lid; other site 759362001800 ABC transporter signature motif; other site 759362001801 Walker B; other site 759362001802 D-loop; other site 759362001803 H-loop/switch region; other site 759362001804 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362001805 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 759362001806 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 759362001807 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362001808 dimer interface [polypeptide binding]; other site 759362001809 conserved gate region; other site 759362001810 putative PBP binding loops; other site 759362001811 ABC-ATPase subunit interface; other site 759362001812 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 759362001813 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362001814 dimer interface [polypeptide binding]; other site 759362001815 conserved gate region; other site 759362001816 putative PBP binding loops; other site 759362001817 ABC-ATPase subunit interface; other site 759362001818 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 759362001819 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 759362001820 non-specific DNA binding site [nucleotide binding]; other site 759362001821 salt bridge; other site 759362001822 sequence-specific DNA binding site [nucleotide binding]; other site 759362001823 Cupin domain; Region: Cupin_2; pfam07883 759362001824 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 759362001825 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 759362001826 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 759362001827 Creatinine amidohydrolase; Region: Creatininase; pfam02633 759362001828 cytidine deaminase; Provisional; Region: PRK09027 759362001829 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 759362001830 active site 759362001831 catalytic motif [active] 759362001832 Zn binding site [ion binding]; other site 759362001833 Cytidine and deoxycytidylate deaminase zinc-binding region; Region: dCMP_cyt_deam_2; pfam08211 759362001834 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 759362001835 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 759362001836 active site 759362001837 putative substrate binding pocket [chemical binding]; other site 759362001838 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 759362001839 active site 759362001840 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 759362001841 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 759362001842 ligand binding site [chemical binding]; other site 759362001843 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 759362001844 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 759362001845 Walker A/P-loop; other site 759362001846 ATP binding site [chemical binding]; other site 759362001847 Q-loop/lid; other site 759362001848 ABC transporter signature motif; other site 759362001849 Walker B; other site 759362001850 D-loop; other site 759362001851 H-loop/switch region; other site 759362001852 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 759362001853 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 759362001854 TM-ABC transporter signature motif; other site 759362001855 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 759362001856 TM-ABC transporter signature motif; other site 759362001857 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 759362001858 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cl01109 759362001859 putative amphipathic alpha helix; other site 759362001860 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 759362001861 dimer interface [polypeptide binding]; other site 759362001862 allosteric magnesium binding site [ion binding]; other site 759362001863 active site 759362001864 aspartate-rich active site metal binding site; other site 759362001865 Schiff base residues; other site 759362001866 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 759362001867 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 759362001868 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 759362001869 ATP binding site [chemical binding]; other site 759362001870 putative Mg++ binding site [ion binding]; other site 759362001871 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 759362001872 nucleotide binding region [chemical binding]; other site 759362001873 ATP-binding site [chemical binding]; other site 759362001874 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 759362001875 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 759362001876 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 759362001877 active site 759362001878 HIGH motif; other site 759362001879 KMSKS motif; other site 759362001880 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 759362001881 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 759362001882 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 759362001883 Peptidase M15; Region: Peptidase_M15_3; cl01194 759362001884 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 759362001885 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 759362001886 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 759362001887 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 759362001888 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 759362001889 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 759362001890 trimer interface [polypeptide binding]; other site 759362001891 active site 759362001892 UDP-GlcNAc binding site [chemical binding]; other site 759362001893 lipid binding site [chemical binding]; lipid-binding site 759362001894 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 759362001895 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 759362001896 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 759362001897 Walker A motif; other site 759362001898 ATP binding site [chemical binding]; other site 759362001899 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 759362001900 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 759362001901 active site 759362001902 DNA binding site [nucleotide binding] 759362001903 Int/Topo IB signature motif; other site 759362001904 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 759362001905 active site 759362001906 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 759362001907 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 759362001908 dimer interface [polypeptide binding]; other site 759362001909 ssDNA binding site [nucleotide binding]; other site 759362001910 tetramer (dimer of dimers) interface [polypeptide binding]; other site 759362001911 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 759362001912 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 759362001913 N-acetyl-D-glucosamine binding site [chemical binding]; other site 759362001914 catalytic residue [active] 759362001915 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 759362001916 Protein of unknown function (DUF563); Region: DUF563; pfam04577 759362001917 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 759362001918 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 759362001919 putative nucleotide binding site [chemical binding]; other site 759362001920 uridine monophosphate binding site [chemical binding]; other site 759362001921 homohexameric interface [polypeptide binding]; other site 759362001922 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 759362001923 ATP binding site [chemical binding]; other site 759362001924 active site 759362001925 substrate binding site [chemical binding]; other site 759362001926 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 759362001927 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 759362001928 putative active site [active] 759362001929 catalytic triad [active] 759362001930 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 759362001931 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 759362001932 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 759362001933 dimer interface [polypeptide binding]; other site 759362001934 phosphorylation site [posttranslational modification] 759362001935 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 759362001936 ATP binding site [chemical binding]; other site 759362001937 Mg2+ binding site [ion binding]; other site 759362001938 G-X-G motif; other site 759362001939 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 759362001940 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759362001941 active site 759362001942 phosphorylation site [posttranslational modification] 759362001943 intermolecular recognition site; other site 759362001944 dimerization interface [polypeptide binding]; other site 759362001945 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759362001946 Walker A motif; other site 759362001947 ATP binding site [chemical binding]; other site 759362001948 Walker B motif; other site 759362001949 arginine finger; other site 759362001950 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 759362001951 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 759362001952 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 759362001953 RNA binding site [nucleotide binding]; other site 759362001954 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 759362001955 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 759362001956 LexA repressor; Validated; Region: PRK00215 759362001957 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 759362001958 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 759362001959 Catalytic site [active] 759362001960 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 759362001961 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 759362001962 dimer interface [polypeptide binding]; other site 759362001963 putative functional site; other site 759362001964 putative MPT binding site; other site 759362001965 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 759362001966 trimer interface [polypeptide binding]; other site 759362001967 dimer interface [polypeptide binding]; other site 759362001968 putative active site [active] 759362001969 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 759362001970 active site 759362001971 ribulose/triose binding site [chemical binding]; other site 759362001972 phosphate binding site [ion binding]; other site 759362001973 substrate (anthranilate) binding pocket [chemical binding]; other site 759362001974 product (indole) binding pocket [chemical binding]; other site 759362001975 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 759362001976 ligand binding site [chemical binding]; other site 759362001977 active site 759362001978 UGI interface [polypeptide binding]; other site 759362001979 catalytic site [active] 759362001980 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 759362001981 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 759362001982 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 759362001983 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14965 759362001984 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 759362001985 anthranilate synthase component I; Provisional; Region: PRK13573 759362001986 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 759362001987 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 759362001988 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 759362001989 SurA N-terminal domain; Region: SurA_N_3; cl07813 759362001990 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 759362001991 hypothetical protein; Provisional; Region: PRK07550 759362001992 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 759362001993 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759362001994 homodimer interface [polypeptide binding]; other site 759362001995 catalytic residue [active] 759362001996 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 759362001997 active site 759362001998 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 759362001999 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 759362002000 NAD binding site [chemical binding]; other site 759362002001 homotetramer interface [polypeptide binding]; other site 759362002002 homodimer interface [polypeptide binding]; other site 759362002003 substrate binding site [chemical binding]; other site 759362002004 active site 759362002005 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 759362002006 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 759362002007 Pyridoxine 5'-phosphate oxidase C-terminal dimerization region; Region: PNPOx_C; pfam10590 759362002008 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 759362002009 DNA-binding site [nucleotide binding]; DNA binding site 759362002010 RNA-binding motif; other site 759362002011 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 759362002012 DNA-binding site [nucleotide binding]; DNA binding site 759362002013 RNA-binding motif; other site 759362002014 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 759362002015 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 759362002016 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 759362002017 NADP-binding site; other site 759362002018 homotetramer interface [polypeptide binding]; other site 759362002019 substrate binding site [chemical binding]; other site 759362002020 homodimer interface [polypeptide binding]; other site 759362002021 active site 759362002022 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 759362002023 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 759362002024 NADP binding site [chemical binding]; other site 759362002025 active site 759362002026 putative substrate binding site [chemical binding]; other site 759362002027 H-NS histone family; Region: Histone_HNS; pfam00816 759362002028 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 759362002029 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 759362002030 excinuclease ABC subunit B; Provisional; Region: PRK05298 759362002031 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 759362002032 ATP binding site [chemical binding]; other site 759362002033 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 759362002034 nucleotide binding region [chemical binding]; other site 759362002035 ATP-binding site [chemical binding]; other site 759362002036 Ultra-violet resistance protein B; Region: UvrB; pfam12344 759362002037 UvrB/uvrC motif; Region: UVR; pfam02151 759362002038 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 759362002039 Coenzyme A binding pocket [chemical binding]; other site 759362002040 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 759362002041 active site 759362002042 putative substrate binding region [chemical binding]; other site 759362002043 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 759362002044 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 759362002045 substrate binding pocket [chemical binding]; other site 759362002046 membrane-bound complex binding site; other site 759362002047 hinge residues; other site 759362002048 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 759362002049 ABC-2 type transporter; Region: ABC2_membrane; cl17235 759362002050 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 759362002051 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759362002052 Walker A/P-loop; other site 759362002053 ATP binding site [chemical binding]; other site 759362002054 Q-loop/lid; other site 759362002055 ABC transporter signature motif; other site 759362002056 Walker B; other site 759362002057 D-loop; other site 759362002058 H-loop/switch region; other site 759362002059 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 759362002060 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 759362002061 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 759362002062 Trp docking motif [polypeptide binding]; other site 759362002063 active site 759362002064 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 759362002065 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 759362002066 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 759362002067 Uncharacterized protein conserved in bacteria (DUF2328); Region: DUF2328; pfam10090 759362002068 Protein of unknown function (DUF3553); Region: DUF3553; pfam12073 759362002069 trigger factor; Provisional; Region: tig; PRK01490 759362002070 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 759362002071 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 759362002072 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 759362002073 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 759362002074 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 759362002075 active site 759362002076 metal binding site [ion binding]; metal-binding site 759362002077 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 759362002078 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 759362002079 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 759362002080 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 759362002081 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 759362002082 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 759362002083 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 759362002084 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 759362002085 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 759362002086 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 759362002087 NAD(P) binding site [chemical binding]; other site 759362002088 homotetramer interface [polypeptide binding]; other site 759362002089 homodimer interface [polypeptide binding]; other site 759362002090 active site 759362002091 acyl carrier protein; Provisional; Region: acpP; PRK00982 759362002092 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 759362002093 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 759362002094 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 759362002095 dimer interface [polypeptide binding]; other site 759362002096 active site 759362002097 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 759362002098 dimerization interface [polypeptide binding]; other site 759362002099 Phage-related protein [Function unknown]; Region: COG4695 759362002100 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 759362002101 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 759362002102 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 759362002103 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 759362002104 oligomerization interface [polypeptide binding]; other site 759362002105 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 759362002106 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 759362002107 Phage major tail protein 2; Region: Phage_tail_2; cl11463 759362002108 Protein of unknown function (DUF3356); Region: DUF3356; pfam11836 759362002109 Conserved hypothetical phage protein (DUF2376); Region: DUF2376; pfam09550 759362002110 Phage-related minor tail protein [Function unknown]; Region: COG5281 759362002111 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; cl19901 759362002112 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343 759362002113 Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931 759362002114 phage conserved hypothetical protein BR0599; Region: phg_TIGR02218 759362002115 Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356 759362002116 NlpC/P60 family; Region: NLPC_P60; cl17555 759362002117 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 759362002118 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 759362002119 Putative phage tail protein; Region: Phage-tail_3; pfam13550 759362002120 serine acetyltransferase; Provisional; Region: cysE; PRK11132 759362002121 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 759362002122 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 759362002123 trimer interface [polypeptide binding]; other site 759362002124 active site 759362002125 substrate binding site [chemical binding]; other site 759362002126 CoA binding site [chemical binding]; other site 759362002127 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 759362002128 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 759362002129 E3 interaction surface; other site 759362002130 lipoyl attachment site [posttranslational modification]; other site 759362002131 e3 binding domain; Region: E3_binding; pfam02817 759362002132 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 759362002133 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 759362002134 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 759362002135 E3 interaction surface; other site 759362002136 lipoyl attachment site [posttranslational modification]; other site 759362002137 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 759362002138 alpha subunit interface [polypeptide binding]; other site 759362002139 TPP binding site [chemical binding]; other site 759362002140 heterodimer interface [polypeptide binding]; other site 759362002141 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 759362002142 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 759362002143 tetramer interface [polypeptide binding]; other site 759362002144 TPP-binding site [chemical binding]; other site 759362002145 heterodimer interface [polypeptide binding]; other site 759362002146 phosphorylation loop region [posttranslational modification] 759362002147 Septum formation initiator; Region: DivIC; pfam04977 759362002148 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 759362002149 catalytic residue [active] 759362002150 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 759362002151 substrate binding site [chemical binding]; other site 759362002152 hinge regions; other site 759362002153 ADP binding site [chemical binding]; other site 759362002154 catalytic site [active] 759362002155 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 759362002156 active site 759362002157 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 759362002158 active site 759362002159 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; cl19499 759362002160 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 759362002161 active site 759362002162 tetramer interface [polypeptide binding]; other site 759362002163 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 759362002164 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 759362002165 putative valine binding site [chemical binding]; other site 759362002166 dimer interface [polypeptide binding]; other site 759362002167 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 759362002168 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 759362002169 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 759362002170 PYR/PP interface [polypeptide binding]; other site 759362002171 dimer interface [polypeptide binding]; other site 759362002172 TPP binding site [chemical binding]; other site 759362002173 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 759362002174 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 759362002175 TPP-binding site [chemical binding]; other site 759362002176 dimer interface [polypeptide binding]; other site 759362002177 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 759362002178 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 759362002179 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 759362002180 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 759362002181 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 759362002182 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 759362002183 multidrug efflux protein; Reviewed; Region: PRK01766 759362002184 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 759362002185 cation binding site [ion binding]; other site 759362002186 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 759362002187 aspartate aminotransferase; Provisional; Region: PRK05764 759362002188 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 759362002189 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759362002190 homodimer interface [polypeptide binding]; other site 759362002191 catalytic residue [active] 759362002192 Flavinator of succinate dehydrogenase; Region: Sdh5; pfam03937 759362002193 Transcriptional regulators [Transcription]; Region: MarR; COG1846 759362002194 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 759362002195 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 759362002196 dimer interface [polypeptide binding]; other site 759362002197 active site 759362002198 metal binding site [ion binding]; metal-binding site 759362002199 glutathione binding site [chemical binding]; other site 759362002200 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 759362002201 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 759362002202 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 759362002203 Peptidase family M23; Region: Peptidase_M23; pfam01551 759362002204 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759362002205 S-adenosylmethionine binding site [chemical binding]; other site 759362002206 Survival protein SurE; Region: SurE; cl00448 759362002207 amidophosphoribosyltransferase; Provisional; Region: PRK09123 759362002208 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 759362002209 active site 759362002210 tetramer interface [polypeptide binding]; other site 759362002211 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 759362002212 active site 759362002213 Colicin V production protein; Region: Colicin_V; pfam02674 759362002214 DNA repair protein RadA; Provisional; Region: PRK11823 759362002215 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 759362002216 Walker A motif/ATP binding site; other site 759362002217 ATP binding site [chemical binding]; other site 759362002218 Walker B motif; other site 759362002219 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 759362002220 hypothetical protein; Validated; Region: PRK09104 759362002221 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 759362002222 metal binding site [ion binding]; metal-binding site 759362002223 putative dimer interface [polypeptide binding]; other site 759362002224 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 759362002225 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 759362002226 substrate-cofactor binding pocket; other site 759362002227 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759362002228 catalytic residue [active] 759362002229 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 759362002230 Helix-turn-helix domain; Region: HTH_25; pfam13413 759362002231 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 759362002232 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 759362002233 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 759362002234 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 759362002235 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 759362002236 catalytic residues [active] 759362002237 hypothetical protein; Provisional; Region: PRK08960 759362002238 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 759362002239 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759362002240 homodimer interface [polypeptide binding]; other site 759362002241 catalytic residue [active] 759362002242 AMIN domain; Region: AMIN; pfam11741 759362002243 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 759362002244 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 759362002245 active site 759362002246 metal binding site [ion binding]; metal-binding site 759362002247 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 759362002248 Transglycosylase; Region: Transgly; pfam00912 759362002249 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 759362002250 peptide chain release factor 2; Validated; Region: prfB; PRK00578 759362002251 This domain is found in peptide chain release factors; Region: PCRF; smart00937 759362002252 RF-1 domain; Region: RF-1; pfam00472 759362002253 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 759362002254 active site 759362002255 catalytic residues [active] 759362002256 DNA binding site [nucleotide binding] 759362002257 Int/Topo IB signature motif; other site 759362002258 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 759362002259 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl19094 759362002260 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cl19048 759362002261 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 759362002262 Phosphopantetheine attachment site; Region: PP-binding; cl09936 759362002263 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 759362002264 DNA binding residues [nucleotide binding] 759362002265 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 759362002266 non-specific DNA binding site [nucleotide binding]; other site 759362002267 salt bridge; other site 759362002268 sequence-specific DNA binding site [nucleotide binding]; other site 759362002269 Predicted transcriptional regulator [Transcription]; Region: COG2932 759362002270 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 759362002271 Catalytic site [active] 759362002272 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 759362002273 CsbD-like; Region: CsbD; cl17424 759362002274 Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720 759362002275 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 759362002276 Phage terminase large subunit (GpA); Region: Terminase_GpA; cl19377 759362002277 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 759362002278 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 759362002279 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 759362002280 oligomer interface [polypeptide binding]; other site 759362002281 active site residues [active] 759362002282 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 759362002283 Uncharacterized conserved protein (DUF2190); Region: DUF2190; pfam09956 759362002284 Fibrillarin-like archaeal protein; Region: Fibrillarin_2; cl19509 759362002285 Putative phage tail protein; Region: Phage-tail_3; pfam13550 759362002286 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 759362002287 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 759362002288 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 759362002289 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 759362002290 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 759362002291 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 759362002292 DoxX-like family; Region: DoxX_2; pfam13564 759362002293 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 759362002294 Protein of unknown function (DUF497); Region: DUF497; cl01108 759362002295 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 759362002296 catalytic residue [active] 759362002297 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 759362002298 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 759362002299 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 759362002300 DNA binding residues [nucleotide binding] 759362002301 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 759362002302 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 759362002303 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 759362002304 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 759362002305 short chain dehydrogenase; Provisional; Region: PRK06139 759362002306 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 759362002307 NAD(P) binding site [chemical binding]; other site 759362002308 active site 759362002309 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4694 759362002310 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759362002311 ABC transporter signature motif; other site 759362002312 Walker B; other site 759362002313 D-loop; other site 759362002314 H-loop/switch region; other site 759362002315 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759362002316 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 759362002317 Walker A motif; other site 759362002318 ATP binding site [chemical binding]; other site 759362002319 Walker B motif; other site 759362002320 Recombinase; Region: Recombinase; pfam07508 759362002321 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 759362002322 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 759362002323 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 759362002324 ABC-ATPase subunit interface; other site 759362002325 dimer interface [polypeptide binding]; other site 759362002326 putative PBP binding regions; other site 759362002327 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 759362002328 ABC-ATPase subunit interface; other site 759362002329 dimer interface [polypeptide binding]; other site 759362002330 putative PBP binding regions; other site 759362002331 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 759362002332 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 759362002333 intersubunit interface [polypeptide binding]; other site 759362002334 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 759362002335 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 759362002336 FAD binding pocket [chemical binding]; other site 759362002337 FAD binding motif [chemical binding]; other site 759362002338 phosphate binding motif [ion binding]; other site 759362002339 NAD binding pocket [chemical binding]; other site 759362002340 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 759362002341 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 759362002342 Walker A/P-loop; other site 759362002343 ATP binding site [chemical binding]; other site 759362002344 Q-loop/lid; other site 759362002345 ABC transporter signature motif; other site 759362002346 Walker B; other site 759362002347 D-loop; other site 759362002348 H-loop/switch region; other site 759362002349 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 759362002350 Transcriptional regulator [Transcription]; Region: IclR; COG1414 759362002351 Bacterial transcriptional regulator; Region: IclR; pfam01614 759362002352 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 759362002353 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 759362002354 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 759362002355 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 759362002356 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 759362002357 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 759362002358 DNA binding residues [nucleotide binding] 759362002359 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 759362002360 trimer interface [polypeptide binding]; other site 759362002361 active site 759362002362 substrate binding site [chemical binding]; other site 759362002363 CoA binding site [chemical binding]; other site 759362002364 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 759362002365 non-specific DNA binding site [nucleotide binding]; other site 759362002366 salt bridge; other site 759362002367 sequence-specific DNA binding site [nucleotide binding]; other site 759362002368 DoxX-like family; Region: DoxX_2; pfam13564 759362002369 ribonuclease D; Region: rnd; TIGR01388 759362002370 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 759362002371 catalytic site [active] 759362002372 putative active site [active] 759362002373 putative substrate binding site [chemical binding]; other site 759362002374 HRDC domain; Region: HRDC; pfam00570 759362002375 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 759362002376 Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism]; Region: osmC; COG1764 759362002377 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 759362002378 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 759362002379 DNA-binding site [nucleotide binding]; DNA binding site 759362002380 FCD domain; Region: FCD; pfam07729 759362002381 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 759362002382 putative hydrophobic ligand binding site [chemical binding]; other site 759362002383 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 759362002384 heme-binding site [chemical binding]; other site 759362002385 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 759362002386 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 759362002387 dimer interface [polypeptide binding]; other site 759362002388 putative CheW interface [polypeptide binding]; other site 759362002389 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 759362002390 putative acyl-acceptor binding pocket; other site 759362002391 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 759362002392 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 759362002393 putative active site [active] 759362002394 heme pocket [chemical binding]; other site 759362002395 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 759362002396 dimer interface [polypeptide binding]; other site 759362002397 phosphorylation site [posttranslational modification] 759362002398 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 759362002399 ATP binding site [chemical binding]; other site 759362002400 Mg2+ binding site [ion binding]; other site 759362002401 G-X-G motif; other site 759362002402 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759362002403 active site 759362002404 phosphorylation site [posttranslational modification] 759362002405 intermolecular recognition site; other site 759362002406 dimerization interface [polypeptide binding]; other site 759362002407 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 759362002408 Methyltransferase domain; Region: Methyltransf_26; pfam13659 759362002409 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 759362002410 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 759362002411 active site 759362002412 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 759362002413 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 759362002414 Competence-damaged protein; Region: CinA; pfam02464 759362002415 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 759362002416 tetramer interfaces [polypeptide binding]; other site 759362002417 binuclear metal-binding site [ion binding]; other site 759362002418 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 759362002419 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 759362002420 substrate binding site; other site 759362002421 dimer interface; other site 759362002422 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 759362002423 homotrimer interaction site [polypeptide binding]; other site 759362002424 zinc binding site [ion binding]; other site 759362002425 CDP-binding sites; other site 759362002426 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 759362002427 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 759362002428 FMN binding site [chemical binding]; other site 759362002429 active site 759362002430 catalytic residues [active] 759362002431 substrate binding site [chemical binding]; other site 759362002432 PAS domain; Region: PAS; smart00091 759362002433 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 759362002434 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 759362002435 dimer interface [polypeptide binding]; other site 759362002436 phosphorylation site [posttranslational modification] 759362002437 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 759362002438 ATP binding site [chemical binding]; other site 759362002439 Mg2+ binding site [ion binding]; other site 759362002440 G-X-G motif; other site 759362002441 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 759362002442 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759362002443 active site 759362002444 phosphorylation site [posttranslational modification] 759362002445 intermolecular recognition site; other site 759362002446 dimerization interface [polypeptide binding]; other site 759362002447 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759362002448 Walker A motif; other site 759362002449 ATP binding site [chemical binding]; other site 759362002450 Walker B motif; other site 759362002451 arginine finger; other site 759362002452 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 759362002453 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 759362002454 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 759362002455 dimerization interface [polypeptide binding]; other site 759362002456 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 759362002457 dimer interface [polypeptide binding]; other site 759362002458 phosphorylation site [posttranslational modification] 759362002459 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 759362002460 ATP binding site [chemical binding]; other site 759362002461 Mg2+ binding site [ion binding]; other site 759362002462 G-X-G motif; other site 759362002463 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 759362002464 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759362002465 active site 759362002466 phosphorylation site [posttranslational modification] 759362002467 intermolecular recognition site; other site 759362002468 dimerization interface [polypeptide binding]; other site 759362002469 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759362002470 Walker B motif; other site 759362002471 arginine finger; other site 759362002472 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 759362002473 Domain of unknown function (DUF305); Region: DUF305; cl17794 759362002474 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 759362002475 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 759362002476 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 759362002477 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 759362002478 dimerization interface [polypeptide binding]; other site 759362002479 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 759362002480 putative active site [active] 759362002481 metal binding site [ion binding]; metal-binding site 759362002482 metabolite-proton symporter; Region: 2A0106; TIGR00883 759362002483 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759362002484 putative substrate translocation pore; other site 759362002485 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 759362002486 dimer interface [polypeptide binding]; other site 759362002487 NADP binding site [chemical binding]; other site 759362002488 catalytic residues [active] 759362002489 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 759362002490 Outer membrane efflux protein; Region: OEP; pfam02321 759362002491 Outer membrane efflux protein; Region: OEP; pfam02321 759362002492 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 759362002493 MMPL family; Region: MMPL; cl14618 759362002494 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 759362002495 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 759362002496 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 759362002497 HlyD family secretion protein; Region: HlyD_3; pfam13437 759362002498 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759362002499 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 759362002500 active site 759362002501 phosphorylation site [posttranslational modification] 759362002502 intermolecular recognition site; other site 759362002503 dimerization interface [polypeptide binding]; other site 759362002504 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 759362002505 DNA binding site [nucleotide binding] 759362002506 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 759362002507 dimerization interface [polypeptide binding]; other site 759362002508 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 759362002509 dimer interface [polypeptide binding]; other site 759362002510 phosphorylation site [posttranslational modification] 759362002511 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 759362002512 ATP binding site [chemical binding]; other site 759362002513 Mg2+ binding site [ion binding]; other site 759362002514 G-X-G motif; other site 759362002515 Protein of unknown function (DUF563); Region: DUF563; pfam04577 759362002516 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 759362002517 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 759362002518 FAD binding pocket [chemical binding]; other site 759362002519 FAD binding motif [chemical binding]; other site 759362002520 phosphate binding motif [ion binding]; other site 759362002521 NAD binding pocket [chemical binding]; other site 759362002522 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 759362002523 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 759362002524 N-terminal plug; other site 759362002525 ligand-binding site [chemical binding]; other site 759362002526 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 759362002527 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 759362002528 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759362002529 Walker A/P-loop; other site 759362002530 ATP binding site [chemical binding]; other site 759362002531 Q-loop/lid; other site 759362002532 ABC transporter signature motif; other site 759362002533 Walker B; other site 759362002534 D-loop; other site 759362002535 H-loop/switch region; other site 759362002536 Protein of unknown function, DUF399; Region: DUF399; pfam04187 759362002537 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 759362002538 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 759362002539 FAD binding pocket [chemical binding]; other site 759362002540 FAD binding motif [chemical binding]; other site 759362002541 phosphate binding motif [ion binding]; other site 759362002542 NAD binding pocket [chemical binding]; other site 759362002543 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 759362002544 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 759362002545 active site 759362002546 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 759362002547 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 759362002548 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 759362002549 catalytic residue [active] 759362002550 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 759362002551 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 759362002552 non-specific DNA binding site [nucleotide binding]; other site 759362002553 salt bridge; other site 759362002554 sequence-specific DNA binding site [nucleotide binding]; other site 759362002555 Cupin domain; Region: Cupin_2; pfam07883 759362002556 N-carbamyl-D-amino acid amidohydrolase (DCase, class 6 nitrilases); Region: DCase; cd07569 759362002557 tetramer interface [polypeptide binding]; other site 759362002558 active site 759362002559 catalytic triad [active] 759362002560 dimer interface [polypeptide binding]; other site 759362002561 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 759362002562 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759362002563 Walker A/P-loop; other site 759362002564 ATP binding site [chemical binding]; other site 759362002565 Q-loop/lid; other site 759362002566 ABC transporter signature motif; other site 759362002567 Walker B; other site 759362002568 D-loop; other site 759362002569 H-loop/switch region; other site 759362002570 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 759362002571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362002572 dimer interface [polypeptide binding]; other site 759362002573 conserved gate region; other site 759362002574 putative PBP binding loops; other site 759362002575 ABC-ATPase subunit interface; other site 759362002576 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 759362002577 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362002578 dimer interface [polypeptide binding]; other site 759362002579 conserved gate region; other site 759362002580 putative PBP binding loops; other site 759362002581 ABC-ATPase subunit interface; other site 759362002582 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 759362002583 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 759362002584 Cu(I) binding site [ion binding]; other site 759362002585 Protein of unknown function (DUF461); Region: DUF461; pfam04314 759362002586 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 759362002587 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 759362002588 Chromate transporter; Region: Chromate_transp; pfam02417 759362002589 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 759362002590 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 759362002591 OpgC protein; Region: OpgC_C; cl17858 759362002592 Entericidin EcnA/B family; Region: Entericidin; cl02322 759362002593 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 759362002594 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 759362002595 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 759362002596 Penicillin amidase; Region: Penicil_amidase; pfam01804 759362002597 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 759362002598 active site 759362002599 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 759362002600 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 759362002601 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 759362002602 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 759362002603 TM-ABC transporter signature motif; other site 759362002604 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 759362002605 TM-ABC transporter signature motif; other site 759362002606 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 759362002607 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 759362002608 Walker A/P-loop; other site 759362002609 ATP binding site [chemical binding]; other site 759362002610 Q-loop/lid; other site 759362002611 ABC transporter signature motif; other site 759362002612 Walker B; other site 759362002613 D-loop; other site 759362002614 H-loop/switch region; other site 759362002615 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 759362002616 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 759362002617 Walker A/P-loop; other site 759362002618 ATP binding site [chemical binding]; other site 759362002619 Q-loop/lid; other site 759362002620 ABC transporter signature motif; other site 759362002621 Walker B; other site 759362002622 D-loop; other site 759362002623 H-loop/switch region; other site 759362002624 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 759362002625 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 759362002626 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 759362002627 PAS domain; Region: PAS_5; cl19562 759362002628 Guanylate kinase; Region: Guanylate_kin; pfam00625 759362002629 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 759362002630 catalytic site [active] 759362002631 G-X2-G-X-G-K; other site 759362002632 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 759362002633 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 759362002634 dimer interface [polypeptide binding]; other site 759362002635 phosphorylation site [posttranslational modification] 759362002636 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 759362002637 ATP binding site [chemical binding]; other site 759362002638 Mg2+ binding site [ion binding]; other site 759362002639 G-X-G motif; other site 759362002640 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 759362002641 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 759362002642 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 759362002643 Predicted permeases [General function prediction only]; Region: RarD; COG2962 759362002644 EamA-like transporter family; Region: EamA; pfam00892 759362002645 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 759362002646 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 759362002647 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 759362002648 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759362002649 Walker A/P-loop; other site 759362002650 ATP binding site [chemical binding]; other site 759362002651 Q-loop/lid; other site 759362002652 ABC transporter signature motif; other site 759362002653 Walker B; other site 759362002654 D-loop; other site 759362002655 H-loop/switch region; other site 759362002656 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 759362002657 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 759362002658 active site 759362002659 PQQ-like domain; Region: PQQ_2; pfam13360 759362002660 Trp docking motif [polypeptide binding]; other site 759362002661 PQQ-like domain; Region: PQQ_2; pfam13360 759362002662 GTP-binding protein Der; Reviewed; Region: PRK00093 759362002663 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 759362002664 G1 box; other site 759362002665 GTP/Mg2+ binding site [chemical binding]; other site 759362002666 Switch I region; other site 759362002667 G2 box; other site 759362002668 Switch II region; other site 759362002669 G3 box; other site 759362002670 G4 box; other site 759362002671 G5 box; other site 759362002672 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 759362002673 G1 box; other site 759362002674 GTP/Mg2+ binding site [chemical binding]; other site 759362002675 Switch I region; other site 759362002676 G2 box; other site 759362002677 G3 box; other site 759362002678 Switch II region; other site 759362002679 G4 box; other site 759362002680 G5 box; other site 759362002681 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 759362002682 seryl-tRNA synthetase; Provisional; Region: PRK05431 759362002683 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 759362002684 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 759362002685 dimer interface [polypeptide binding]; other site 759362002686 active site 759362002687 motif 1; other site 759362002688 motif 2; other site 759362002689 motif 3; other site 759362002690 Preprotein translocase subunit; Region: YajC; pfam02699 759362002691 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 759362002692 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759362002693 Walker A/P-loop; other site 759362002694 ATP binding site [chemical binding]; other site 759362002695 Q-loop/lid; other site 759362002696 ABC transporter signature motif; other site 759362002697 Walker B; other site 759362002698 D-loop; other site 759362002699 H-loop/switch region; other site 759362002700 heme exporter protein CcmB; Region: ccmB; TIGR01190 759362002701 heme exporter protein CcmC; Region: ccmC; TIGR01191 759362002702 Heme exporter protein D (CcmD); Region: CcmD; pfam04995 759362002703 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 759362002704 catalytic residues [active] 759362002705 central insert; other site 759362002706 aconitate hydratase; Validated; Region: PRK09277 759362002707 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 759362002708 substrate binding site [chemical binding]; other site 759362002709 ligand binding site [chemical binding]; other site 759362002710 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 759362002711 substrate binding site [chemical binding]; other site 759362002712 Protein of unknown function (DUF1223); Region: DUF1223; pfam06764 759362002713 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 759362002714 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 759362002715 trimer interface [polypeptide binding]; other site 759362002716 active site 759362002717 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 759362002718 trimer interface [polypeptide binding]; other site 759362002719 active site 759362002720 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 759362002721 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 759362002722 DNA binding residues [nucleotide binding] 759362002723 Alpha subunit of integration host factor (IHFA); Region: IHF_A; cd13835 759362002724 DNA binding site [nucleotide binding] 759362002725 dimer interface [polypeptide binding]; other site 759362002726 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 759362002727 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 759362002728 dimer interface [polypeptide binding]; other site 759362002729 active site 759362002730 CoA binding pocket [chemical binding]; other site 759362002731 putative phosphate acyltransferase; Provisional; Region: PRK05331 759362002732 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 759362002733 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 759362002734 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 759362002735 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 759362002736 methionine sulfoxide reductase B; Provisional; Region: PRK00222 759362002737 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 759362002738 ABC transporter ATPase component; Reviewed; Region: PRK11147 759362002739 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 759362002740 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 759362002741 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 759362002742 G1 box; other site 759362002743 GTP/Mg2+ binding site [chemical binding]; other site 759362002744 G2 box; other site 759362002745 Switch I region; other site 759362002746 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 759362002747 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 759362002748 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 759362002749 homodimer interface [polypeptide binding]; other site 759362002750 metal binding site [ion binding]; metal-binding site 759362002751 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 759362002752 homodimer interface [polypeptide binding]; other site 759362002753 active site 759362002754 putative chemical substrate binding site [chemical binding]; other site 759362002755 metal binding site [ion binding]; metal-binding site 759362002756 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 759362002757 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 759362002758 metal binding site [ion binding]; metal-binding site 759362002759 putative dimer interface [polypeptide binding]; other site 759362002760 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 759362002761 oligomer interface [polypeptide binding]; other site 759362002762 putative active site [active] 759362002763 Mn binding site [ion binding]; other site 759362002764 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 759362002765 alanine racemase; Reviewed; Region: alr; PRK00053 759362002766 active site 759362002767 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 759362002768 dimer interface [polypeptide binding]; other site 759362002769 substrate binding site [chemical binding]; other site 759362002770 catalytic residues [active] 759362002771 replicative DNA helicase; Provisional; Region: PRK09165 759362002772 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 759362002773 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 759362002774 Walker A motif; other site 759362002775 ATP binding site [chemical binding]; other site 759362002776 Walker B motif; other site 759362002777 DNA binding loops [nucleotide binding] 759362002778 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 759362002779 active site 759362002780 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 759362002781 active site 759362002782 substrate binding pocket [chemical binding]; other site 759362002783 dimer interface [polypeptide binding]; other site 759362002784 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 759362002785 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 759362002786 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 759362002787 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 759362002788 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 759362002789 FAD binding pocket [chemical binding]; other site 759362002790 FAD binding motif [chemical binding]; other site 759362002791 phosphate binding motif [ion binding]; other site 759362002792 beta-alpha-beta structure motif; other site 759362002793 NAD binding pocket [chemical binding]; other site 759362002794 Cation efflux family; Region: Cation_efflux; cl00316 759362002795 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 759362002796 substrate binding site [chemical binding]; other site 759362002797 dimer interface [polypeptide binding]; other site 759362002798 catalytic triad [active] 759362002799 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 759362002800 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 759362002801 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 759362002802 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 759362002803 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 759362002804 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 759362002805 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759362002806 Walker A motif; other site 759362002807 ATP binding site [chemical binding]; other site 759362002808 Walker B motif; other site 759362002809 arginine finger; other site 759362002810 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 759362002811 bacterial Hfq-like; Region: Hfq; cd01716 759362002812 hexamer interface [polypeptide binding]; other site 759362002813 Sm1 motif; other site 759362002814 RNA binding site [nucleotide binding]; other site 759362002815 Sm2 motif; other site 759362002816 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 759362002817 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 759362002818 HflX GTPase family; Region: HflX; cd01878 759362002819 G1 box; other site 759362002820 GTP/Mg2+ binding site [chemical binding]; other site 759362002821 Switch I region; other site 759362002822 G2 box; other site 759362002823 G3 box; other site 759362002824 Switch II region; other site 759362002825 G4 box; other site 759362002826 G5 box; other site 759362002827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759362002828 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 759362002829 putative substrate translocation pore; other site 759362002830 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 759362002831 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 759362002832 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 759362002833 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 759362002834 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 759362002835 substrate binding site [chemical binding]; other site 759362002836 ATP binding site [chemical binding]; other site 759362002837 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 759362002838 Protein of unknown function (DUF1501); Region: DUF1501; cl19855 759362002839 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 759362002840 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 759362002841 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 759362002842 Walker A/P-loop; other site 759362002843 ATP binding site [chemical binding]; other site 759362002844 Q-loop/lid; other site 759362002845 ABC transporter signature motif; other site 759362002846 Walker B; other site 759362002847 D-loop; other site 759362002848 H-loop/switch region; other site 759362002849 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 759362002850 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362002851 dimer interface [polypeptide binding]; other site 759362002852 conserved gate region; other site 759362002853 putative PBP binding loops; other site 759362002854 ABC-ATPase subunit interface; other site 759362002855 short chain dehydrogenase; Provisional; Region: PRK07041 759362002856 classical (c) SDRs; Region: SDR_c; cd05233 759362002857 NAD(P) binding site [chemical binding]; other site 759362002858 active site 759362002859 Transcriptional regulator [Transcription]; Region: LysR; COG0583 759362002860 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 759362002861 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 759362002862 putative effector binding pocket; other site 759362002863 dimerization interface [polypeptide binding]; other site 759362002864 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 759362002865 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 759362002866 N-terminal plug; other site 759362002867 ligand-binding site [chemical binding]; other site 759362002868 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 759362002869 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 759362002870 FAD binding pocket [chemical binding]; other site 759362002871 FAD binding motif [chemical binding]; other site 759362002872 phosphate binding motif [ion binding]; other site 759362002873 NAD binding pocket [chemical binding]; other site 759362002874 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 759362002875 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 759362002876 intersubunit interface [polypeptide binding]; other site 759362002877 EamA-like transporter family; Region: EamA; pfam00892 759362002878 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 759362002879 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 759362002880 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 759362002881 putative DNA binding site [nucleotide binding]; other site 759362002882 putative Zn2+ binding site [ion binding]; other site 759362002883 AsnC family; Region: AsnC_trans_reg; pfam01037 759362002884 Transcriptional regulators [Transcription]; Region: GntR; COG1802 759362002885 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 759362002886 DNA-binding site [nucleotide binding]; DNA binding site 759362002887 FCD domain; Region: FCD; pfam07729 759362002888 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 759362002889 Protein of unknown function (DUF1284); Region: DUF1284; cl01419 759362002890 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 759362002891 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 759362002892 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 759362002893 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362002894 Walker A/P-loop; other site 759362002895 ATP binding site [chemical binding]; other site 759362002896 Q-loop/lid; other site 759362002897 ABC transporter signature motif; other site 759362002898 Walker B; other site 759362002899 D-loop; other site 759362002900 H-loop/switch region; other site 759362002901 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 759362002902 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362002903 Walker A/P-loop; other site 759362002904 ATP binding site [chemical binding]; other site 759362002905 Q-loop/lid; other site 759362002906 ABC transporter signature motif; other site 759362002907 Walker B; other site 759362002908 D-loop; other site 759362002909 H-loop/switch region; other site 759362002910 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 759362002911 Uncharacterized conserved protein [Function unknown]; Region: COG5476 759362002912 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 759362002913 MlrC C-terminus; Region: MlrC_C; pfam07171 759362002914 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 759362002915 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 759362002916 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 759362002917 nucleotide binding site [chemical binding]; other site 759362002918 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 759362002919 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 759362002920 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 759362002921 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 759362002922 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362002923 dimer interface [polypeptide binding]; other site 759362002924 conserved gate region; other site 759362002925 putative PBP binding loops; other site 759362002926 ABC-ATPase subunit interface; other site 759362002927 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 759362002928 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 759362002929 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362002930 dimer interface [polypeptide binding]; other site 759362002931 conserved gate region; other site 759362002932 putative PBP binding loops; other site 759362002933 ABC-ATPase subunit interface; other site 759362002934 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 759362002935 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 759362002936 nucleotide binding site [chemical binding]; other site 759362002937 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 759362002938 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 759362002939 tetrameric interface [polypeptide binding]; other site 759362002940 NAD binding site [chemical binding]; other site 759362002941 catalytic residues [active] 759362002942 Transcriptional regulator [Transcription]; Region: LysR; COG0583 759362002943 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 759362002944 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 759362002945 dimerization interface [polypeptide binding]; other site 759362002946 Probable beta-xylosidase; Provisional; Region: PLN03080 759362002947 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 759362002948 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 759362002949 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; cl08459 759362002950 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 759362002951 amidase; Provisional; Region: PRK07042 759362002952 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362002953 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 759362002954 Walker A/P-loop; other site 759362002955 ATP binding site [chemical binding]; other site 759362002956 Q-loop/lid; other site 759362002957 ABC transporter signature motif; other site 759362002958 Walker B; other site 759362002959 D-loop; other site 759362002960 H-loop/switch region; other site 759362002961 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362002962 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 759362002963 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362002964 Walker A/P-loop; other site 759362002965 ATP binding site [chemical binding]; other site 759362002966 Q-loop/lid; other site 759362002967 ABC transporter signature motif; other site 759362002968 Walker B; other site 759362002969 D-loop; other site 759362002970 H-loop/switch region; other site 759362002971 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362002972 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 759362002973 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362002974 dimer interface [polypeptide binding]; other site 759362002975 conserved gate region; other site 759362002976 putative PBP binding loops; other site 759362002977 ABC-ATPase subunit interface; other site 759362002978 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 759362002979 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362002980 dimer interface [polypeptide binding]; other site 759362002981 conserved gate region; other site 759362002982 putative PBP binding loops; other site 759362002983 ABC-ATPase subunit interface; other site 759362002984 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 759362002985 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 759362002986 Transcriptional regulator [Transcription]; Region: LysR; COG0583 759362002987 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 759362002988 LysR substrate binding domain; Region: LysR_substrate; pfam03466 759362002989 dimerization interface [polypeptide binding]; other site 759362002990 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 759362002991 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 759362002992 inhibitor-cofactor binding pocket; inhibition site 759362002993 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759362002994 catalytic residue [active] 759362002995 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 759362002996 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 759362002997 non-specific DNA binding site [nucleotide binding]; other site 759362002998 salt bridge; other site 759362002999 sequence-specific DNA binding site [nucleotide binding]; other site 759362003000 Cupin domain; Region: Cupin_2; pfam07883 759362003001 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 759362003002 putative active site pocket [active] 759362003003 cleavage site 759362003004 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 759362003005 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 759362003006 catalytic residue [active] 759362003007 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 759362003008 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 759362003009 FeS assembly ATPase SufC; Region: sufC; TIGR01978 759362003010 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 759362003011 Walker A/P-loop; other site 759362003012 ATP binding site [chemical binding]; other site 759362003013 Q-loop/lid; other site 759362003014 ABC transporter signature motif; other site 759362003015 Walker B; other site 759362003016 D-loop; other site 759362003017 H-loop/switch region; other site 759362003018 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 759362003019 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 759362003020 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 759362003021 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 759362003022 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 759362003023 catalytic residue [active] 759362003024 Transcriptional regulator; Region: Rrf2; cl17282 759362003025 Rrf2 family protein; Region: rrf2_super; TIGR00738 759362003026 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 759362003027 Putative lysophospholipase; Region: Hydrolase_4; cl19140 759362003028 HD domain; Region: HD_3; pfam13023 759362003029 Uncharacterized conserved protein [Function unknown]; Region: COG1284 759362003030 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 759362003031 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 759362003032 Uncharacterized conserved protein [Function unknown]; Region: COG1284 759362003033 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 759362003034 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 759362003035 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 759362003036 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 759362003037 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 759362003038 G1 box; other site 759362003039 putative GEF interaction site [polypeptide binding]; other site 759362003040 GTP/Mg2+ binding site [chemical binding]; other site 759362003041 Switch I region; other site 759362003042 G2 box; other site 759362003043 G3 box; other site 759362003044 Switch II region; other site 759362003045 G4 box; other site 759362003046 G5 box; other site 759362003047 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 759362003048 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 759362003049 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 759362003050 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 759362003051 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 759362003052 motif 1; other site 759362003053 active site 759362003054 motif 2; other site 759362003055 motif 3; other site 759362003056 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 759362003057 recombinase A; Provisional; Region: recA; PRK09354 759362003058 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 759362003059 hexamer interface [polypeptide binding]; other site 759362003060 Walker A motif; other site 759362003061 ATP binding site [chemical binding]; other site 759362003062 Walker B motif; other site 759362003063 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 759362003064 HAMP domain; Region: HAMP; pfam00672 759362003065 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 759362003066 dimer interface [polypeptide binding]; other site 759362003067 phosphorylation site [posttranslational modification] 759362003068 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 759362003069 ATP binding site [chemical binding]; other site 759362003070 Mg2+ binding site [ion binding]; other site 759362003071 G-X-G motif; other site 759362003072 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 759362003073 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362003074 Walker A/P-loop; other site 759362003075 ATP binding site [chemical binding]; other site 759362003076 Q-loop/lid; other site 759362003077 ABC transporter signature motif; other site 759362003078 Walker B; other site 759362003079 D-loop; other site 759362003080 H-loop/switch region; other site 759362003081 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362003082 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 759362003083 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362003084 Walker A/P-loop; other site 759362003085 ATP binding site [chemical binding]; other site 759362003086 Q-loop/lid; other site 759362003087 ABC transporter signature motif; other site 759362003088 Walker B; other site 759362003089 D-loop; other site 759362003090 H-loop/switch region; other site 759362003091 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362003092 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 759362003093 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 759362003094 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 759362003095 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362003096 dimer interface [polypeptide binding]; other site 759362003097 conserved gate region; other site 759362003098 putative PBP binding loops; other site 759362003099 ABC-ATPase subunit interface; other site 759362003100 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 759362003101 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 759362003102 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362003103 dimer interface [polypeptide binding]; other site 759362003104 conserved gate region; other site 759362003105 putative PBP binding loops; other site 759362003106 ABC-ATPase subunit interface; other site 759362003107 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 759362003108 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 759362003109 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 759362003110 active site 759362003111 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 759362003112 Putative lysophospholipase; Region: Hydrolase_4; cl19140 759362003113 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 759362003114 Putative lysophospholipase; Region: Hydrolase_4; cl19140 759362003115 recombination factor protein RarA; Reviewed; Region: PRK13342 759362003116 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759362003117 Walker A motif; other site 759362003118 ATP binding site [chemical binding]; other site 759362003119 Walker B motif; other site 759362003120 arginine finger; other site 759362003121 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 759362003122 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 759362003123 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 759362003124 catalytic Zn binding site [ion binding]; other site 759362003125 NAD(P) binding site [chemical binding]; other site 759362003126 structural Zn binding site [ion binding]; other site 759362003127 Glycoside-hydrolase family GH114; Region: Glyco_hydro_114; pfam03537 759362003128 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 759362003129 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 759362003130 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362003131 Walker A/P-loop; other site 759362003132 ATP binding site [chemical binding]; other site 759362003133 Q-loop/lid; other site 759362003134 ABC transporter signature motif; other site 759362003135 Walker B; other site 759362003136 D-loop; other site 759362003137 H-loop/switch region; other site 759362003138 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362003139 Walker A/P-loop; other site 759362003140 ATP binding site [chemical binding]; other site 759362003141 Q-loop/lid; other site 759362003142 ABC transporter signature motif; other site 759362003143 Walker B; other site 759362003144 D-loop; other site 759362003145 H-loop/switch region; other site 759362003146 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362003147 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 759362003148 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362003149 dimer interface [polypeptide binding]; other site 759362003150 conserved gate region; other site 759362003151 putative PBP binding loops; other site 759362003152 ABC-ATPase subunit interface; other site 759362003153 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 759362003154 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362003155 dimer interface [polypeptide binding]; other site 759362003156 conserved gate region; other site 759362003157 putative PBP binding loops; other site 759362003158 ABC-ATPase subunit interface; other site 759362003159 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 759362003160 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 759362003161 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 759362003162 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 759362003163 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 759362003164 motif II; other site 759362003165 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 759362003166 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 759362003167 catalytic residue [active] 759362003168 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 759362003169 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362003170 Walker A/P-loop; other site 759362003171 ATP binding site [chemical binding]; other site 759362003172 Q-loop/lid; other site 759362003173 ABC transporter signature motif; other site 759362003174 Walker B; other site 759362003175 D-loop; other site 759362003176 H-loop/switch region; other site 759362003177 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 759362003178 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362003179 Walker A/P-loop; other site 759362003180 ATP binding site [chemical binding]; other site 759362003181 Q-loop/lid; other site 759362003182 ABC transporter signature motif; other site 759362003183 Walker B; other site 759362003184 D-loop; other site 759362003185 H-loop/switch region; other site 759362003186 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362003187 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 759362003188 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362003189 dimer interface [polypeptide binding]; other site 759362003190 conserved gate region; other site 759362003191 putative PBP binding loops; other site 759362003192 ABC-ATPase subunit interface; other site 759362003193 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 759362003194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362003195 dimer interface [polypeptide binding]; other site 759362003196 conserved gate region; other site 759362003197 putative PBP binding loops; other site 759362003198 ABC-ATPase subunit interface; other site 759362003199 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 759362003200 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 759362003201 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 759362003202 FMN binding site [chemical binding]; other site 759362003203 dimer interface [polypeptide binding]; other site 759362003204 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 759362003205 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759362003206 putative substrate translocation pore; other site 759362003207 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 759362003208 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 759362003209 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 759362003210 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 759362003211 dimer interface [polypeptide binding]; other site 759362003212 phosphorylation site [posttranslational modification] 759362003213 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 759362003214 ATP binding site [chemical binding]; other site 759362003215 Mg2+ binding site [ion binding]; other site 759362003216 G-X-G motif; other site 759362003217 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 759362003218 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759362003219 active site 759362003220 phosphorylation site [posttranslational modification] 759362003221 intermolecular recognition site; other site 759362003222 dimerization interface [polypeptide binding]; other site 759362003223 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759362003224 Walker A motif; other site 759362003225 ATP binding site [chemical binding]; other site 759362003226 Walker B motif; other site 759362003227 arginine finger; other site 759362003228 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 759362003229 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 759362003230 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 759362003231 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 759362003232 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 759362003233 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 759362003234 Transcriptional regulator [Transcription]; Region: LysR; COG0583 759362003235 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 759362003236 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 759362003237 dimerization interface [polypeptide binding]; other site 759362003238 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 759362003239 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 759362003240 metal binding site [ion binding]; metal-binding site 759362003241 putative dimer interface [polypeptide binding]; other site 759362003242 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 759362003243 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 759362003244 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 759362003245 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362003246 dimer interface [polypeptide binding]; other site 759362003247 conserved gate region; other site 759362003248 putative PBP binding loops; other site 759362003249 ABC-ATPase subunit interface; other site 759362003250 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 759362003251 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362003252 dimer interface [polypeptide binding]; other site 759362003253 conserved gate region; other site 759362003254 putative PBP binding loops; other site 759362003255 ABC-ATPase subunit interface; other site 759362003256 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 759362003257 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362003258 Walker A/P-loop; other site 759362003259 ATP binding site [chemical binding]; other site 759362003260 Q-loop/lid; other site 759362003261 ABC transporter signature motif; other site 759362003262 Walker B; other site 759362003263 D-loop; other site 759362003264 H-loop/switch region; other site 759362003265 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362003266 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362003267 Walker A/P-loop; other site 759362003268 ATP binding site [chemical binding]; other site 759362003269 Q-loop/lid; other site 759362003270 ABC transporter signature motif; other site 759362003271 Walker B; other site 759362003272 D-loop; other site 759362003273 H-loop/switch region; other site 759362003274 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 759362003275 D-glutamate deacylase; Validated; Region: PRK09061 759362003276 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 759362003277 active site 759362003278 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 759362003279 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 759362003280 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 759362003281 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 759362003282 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 759362003283 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 759362003284 hypothetical protein; Provisional; Region: PRK08204 759362003285 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 759362003286 active site 759362003287 Predicted transcriptional regulators [Transcription]; Region: COG1733 759362003288 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 759362003289 metal binding site [ion binding]; metal-binding site 759362003290 active site 759362003291 I-site; other site 759362003292 RNA polymerase sigma factor; Provisional; Region: PRK12514 759362003293 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 759362003294 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 759362003295 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343 759362003296 Anti-sigma-K factor rskA; Region: RskA; pfam10099 759362003297 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 759362003298 Fasciclin domain; Region: Fasciclin; pfam02469 759362003299 Domain of unknown function (DUF4394); Region: DUF4394; pfam14339 759362003300 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 759362003301 DNA-binding site [nucleotide binding]; DNA binding site 759362003302 RNA-binding motif; other site 759362003303 Protein of unknown function (DUF982); Region: DUF982; pfam06169 759362003304 Barstar (barnase inhibitor); Region: Barstar; pfam01337 759362003305 RNAase interaction site [polypeptide binding]; other site 759362003306 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 759362003307 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 759362003308 active site 759362003309 Int/Topo IB signature motif; other site 759362003310 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl19825 759362003311 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 759362003312 DNA gyrase subunit A; Validated; Region: PRK05560 759362003313 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 759362003314 CAP-like domain; other site 759362003315 active site 759362003316 primary dimer interface [polypeptide binding]; other site 759362003317 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 759362003318 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 759362003319 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 759362003320 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 759362003321 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 759362003322 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 759362003323 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 759362003324 Glucose inhibited division protein A; Region: GIDA; pfam01134 759362003325 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 759362003326 active site 759362003327 KMSKS motif; other site 759362003328 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 759362003329 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 759362003330 trimerization site [polypeptide binding]; other site 759362003331 active site 759362003332 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 759362003333 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 759362003334 generic binding surface II; other site 759362003335 ssDNA binding site; other site 759362003336 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 759362003337 ATP binding site [chemical binding]; other site 759362003338 putative Mg++ binding site [ion binding]; other site 759362003339 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 759362003340 nucleotide binding region [chemical binding]; other site 759362003341 ATP-binding site [chemical binding]; other site 759362003342 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 759362003343 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 759362003344 nucleotide binding pocket [chemical binding]; other site 759362003345 K-X-D-G motif; other site 759362003346 catalytic site [active] 759362003347 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 759362003348 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 759362003349 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 759362003350 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 759362003351 Dimer interface [polypeptide binding]; other site 759362003352 BRCT sequence motif; other site 759362003353 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 759362003354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759362003355 active site 759362003356 phosphorylation site [posttranslational modification] 759362003357 intermolecular recognition site; other site 759362003358 dimerization interface [polypeptide binding]; other site 759362003359 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 759362003360 DNA binding site [nucleotide binding] 759362003361 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 759362003362 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 759362003363 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 759362003364 Ligand Binding Site [chemical binding]; other site 759362003365 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 759362003366 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 759362003367 Protein of unknown function (DUF1009); Region: DUF1009; cl09182 759362003368 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 759362003369 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 759362003370 active site 759362003371 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 759362003372 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 759362003373 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 759362003374 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 759362003375 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 759362003376 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 759362003377 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 759362003378 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 759362003379 Surface antigen; Region: Bac_surface_Ag; pfam01103 759362003380 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 759362003381 RIP metalloprotease RseP; Region: TIGR00054 759362003382 active site 759362003383 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 759362003384 protein binding site [polypeptide binding]; other site 759362003385 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 759362003386 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 759362003387 putative substrate binding region [chemical binding]; other site 759362003388 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 759362003389 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 759362003390 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 759362003391 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 759362003392 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 759362003393 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 759362003394 active site 759362003395 dimer interface [polypeptide binding]; other site 759362003396 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 759362003397 hinge region; other site 759362003398 acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814 759362003399 DNA sequence specific (IHF) and non-specific (HU) domains; Region: HU_IHF; cl00257 759362003400 DNA binding site [nucleotide binding] 759362003401 dimer interface [polypeptide binding]; other site 759362003402 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 759362003403 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 759362003404 Walker A/P-loop; other site 759362003405 ATP binding site [chemical binding]; other site 759362003406 Q-loop/lid; other site 759362003407 ABC transporter signature motif; other site 759362003408 Walker B; other site 759362003409 D-loop; other site 759362003410 H-loop/switch region; other site 759362003411 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 759362003412 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362003413 dimer interface [polypeptide binding]; other site 759362003414 conserved gate region; other site 759362003415 putative PBP binding loops; other site 759362003416 ABC-ATPase subunit interface; other site 759362003417 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 759362003418 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 759362003419 metal binding site [ion binding]; metal-binding site 759362003420 putative dimer interface [polypeptide binding]; other site 759362003421 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 759362003422 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 759362003423 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759362003424 Major Facilitator Superfamily; Region: MFS_1; pfam07690 759362003425 putative substrate translocation pore; other site 759362003426 Transcriptional regulators [Transcription]; Region: GntR; COG1802 759362003427 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 759362003428 DNA-binding site [nucleotide binding]; DNA binding site 759362003429 FCD domain; Region: FCD; pfam07729 759362003430 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 759362003431 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 759362003432 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 759362003433 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362003434 Walker A/P-loop; other site 759362003435 ATP binding site [chemical binding]; other site 759362003436 Q-loop/lid; other site 759362003437 ABC transporter signature motif; other site 759362003438 Walker B; other site 759362003439 D-loop; other site 759362003440 H-loop/switch region; other site 759362003441 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362003442 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362003443 Walker A/P-loop; other site 759362003444 ATP binding site [chemical binding]; other site 759362003445 Q-loop/lid; other site 759362003446 ABC transporter signature motif; other site 759362003447 Walker B; other site 759362003448 D-loop; other site 759362003449 H-loop/switch region; other site 759362003450 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362003451 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 759362003452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362003453 dimer interface [polypeptide binding]; other site 759362003454 conserved gate region; other site 759362003455 putative PBP binding loops; other site 759362003456 ABC-ATPase subunit interface; other site 759362003457 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 759362003458 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362003459 dimer interface [polypeptide binding]; other site 759362003460 conserved gate region; other site 759362003461 putative PBP binding loops; other site 759362003462 ABC-ATPase subunit interface; other site 759362003463 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 759362003464 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 759362003465 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 759362003466 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 759362003467 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 759362003468 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 759362003469 Walker A/P-loop; other site 759362003470 ATP binding site [chemical binding]; other site 759362003471 Q-loop/lid; other site 759362003472 ABC transporter signature motif; other site 759362003473 Walker B; other site 759362003474 D-loop; other site 759362003475 H-loop/switch region; other site 759362003476 NIL domain; Region: NIL; pfam09383 759362003477 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 759362003478 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362003479 dimer interface [polypeptide binding]; other site 759362003480 conserved gate region; other site 759362003481 putative PBP binding loops; other site 759362003482 ABC-ATPase subunit interface; other site 759362003483 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 759362003484 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 759362003485 active site 759362003486 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 759362003487 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 759362003488 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 759362003489 active site 759362003490 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 759362003491 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 759362003492 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 759362003493 metal binding site [ion binding]; metal-binding site 759362003494 putative dimer interface [polypeptide binding]; other site 759362003495 hypothetical protein; Validated; Region: PRK09104 759362003496 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 759362003497 metal binding site [ion binding]; metal-binding site 759362003498 putative dimer interface [polypeptide binding]; other site 759362003499 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 759362003500 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759362003501 Walker A/P-loop; other site 759362003502 ATP binding site [chemical binding]; other site 759362003503 Q-loop/lid; other site 759362003504 ABC transporter signature motif; other site 759362003505 Walker B; other site 759362003506 D-loop; other site 759362003507 H-loop/switch region; other site 759362003508 TOBE domain; Region: TOBE_2; pfam08402 759362003509 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 759362003510 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 759362003511 NAD(P) binding site [chemical binding]; other site 759362003512 active site 759362003513 anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451 759362003514 Putative zinc-finger; Region: zf-HC2; pfam13490 759362003515 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 759362003516 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 759362003517 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 759362003518 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 759362003519 DNA binding residues [nucleotide binding] 759362003520 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 759362003521 DNA photolyase; Region: DNA_photolyase; pfam00875 759362003522 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 759362003523 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 759362003524 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 759362003525 MOFRL family; Region: MOFRL; pfam05161 759362003526 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 759362003527 homotrimer interaction site [polypeptide binding]; other site 759362003528 putative active site [active] 759362003529 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 759362003530 Protein of unknown function (DUF983); Region: DUF983; cl02211 759362003531 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 759362003532 catalytic residues [active] 759362003533 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 759362003534 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 759362003535 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 759362003536 Class I ribonucleotide reductase; Region: RNR_I; cd01679 759362003537 active site 759362003538 dimer interface [polypeptide binding]; other site 759362003539 catalytic residues [active] 759362003540 effector binding site; other site 759362003541 R2 peptide binding site; other site 759362003542 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 759362003543 dimer interface [polypeptide binding]; other site 759362003544 diiron center [ion binding]; other site 759362003545 putative radical transfer pathway; other site 759362003546 tyrosyl radical; other site 759362003547 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 759362003548 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 759362003549 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 759362003550 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 759362003551 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 759362003552 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 759362003553 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 759362003554 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 759362003555 lipoyl attachment site [posttranslational modification]; other site 759362003556 glycine dehydrogenase; Provisional; Region: PRK05367 759362003557 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 759362003558 tetramer interface [polypeptide binding]; other site 759362003559 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759362003560 catalytic residue [active] 759362003561 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 759362003562 tetramer interface [polypeptide binding]; other site 759362003563 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759362003564 catalytic residue [active] 759362003565 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 759362003566 putative active site [active] 759362003567 putative metal binding site [ion binding]; other site 759362003568 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 759362003569 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 759362003570 active site 759362003571 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 759362003572 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 759362003573 dimerization interface [polypeptide binding]; other site 759362003574 putative DNA binding site [nucleotide binding]; other site 759362003575 putative Zn2+ binding site [ion binding]; other site 759362003576 AsnC family; Region: AsnC_trans_reg; pfam01037 759362003577 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 759362003578 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759362003579 Walker A/P-loop; other site 759362003580 ATP binding site [chemical binding]; other site 759362003581 Q-loop/lid; other site 759362003582 ABC transporter signature motif; other site 759362003583 Walker B; other site 759362003584 D-loop; other site 759362003585 H-loop/switch region; other site 759362003586 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 759362003587 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 759362003588 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362003589 dimer interface [polypeptide binding]; other site 759362003590 conserved gate region; other site 759362003591 putative PBP binding loops; other site 759362003592 ABC-ATPase subunit interface; other site 759362003593 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 759362003594 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362003595 dimer interface [polypeptide binding]; other site 759362003596 conserved gate region; other site 759362003597 putative PBP binding loops; other site 759362003598 ABC-ATPase subunit interface; other site 759362003599 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 759362003600 Mechanosensitive ion channel; Region: MS_channel; pfam00924 759362003601 cysteine synthase; Region: PLN02565 759362003602 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 759362003603 dimer interface [polypeptide binding]; other site 759362003604 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759362003605 catalytic residue [active] 759362003606 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 759362003607 dimer interface [polypeptide binding]; other site 759362003608 ADP-ribose binding site [chemical binding]; other site 759362003609 active site 759362003610 nudix motif; other site 759362003611 metal binding site [ion binding]; metal-binding site 759362003612 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 759362003613 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 759362003614 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759362003615 S-adenosylmethionine binding site [chemical binding]; other site 759362003616 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 759362003617 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 759362003618 active site 759362003619 Stringent starvation protein B; Region: SspB; pfam04386 759362003620 fumarate hydratase; Reviewed; Region: fumC; PRK00485 759362003621 Class II fumarases; Region: Fumarase_classII; cd01362 759362003622 active site 759362003623 tetramer interface [polypeptide binding]; other site 759362003624 Domain of unknown function (DUF4169); Region: DUF4169; pfam13770 759362003625 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 759362003626 Cytochrome P450; Region: p450; cl12078 759362003627 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 759362003628 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 759362003629 active site 759362003630 dimer interface [polypeptide binding]; other site 759362003631 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 759362003632 dimer interface [polypeptide binding]; other site 759362003633 active site 759362003634 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 759362003635 putative active site [active] 759362003636 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 759362003637 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 759362003638 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 759362003639 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 759362003640 active site 759362003641 elongation factor P; Validated; Region: PRK00529 759362003642 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 759362003643 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 759362003644 RNA binding site [nucleotide binding]; other site 759362003645 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 759362003646 RNA binding site [nucleotide binding]; other site 759362003647 Truncated, possibly inactive, lysyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Region: COG2269 759362003648 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 759362003649 motif 1; other site 759362003650 dimer interface [polypeptide binding]; other site 759362003651 active site 759362003652 motif 2; other site 759362003653 motif 3; other site 759362003654 Nucleoside diphosphate kinase; Region: NDK; pfam00334 759362003655 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 759362003656 active site 759362003657 multimer interface [polypeptide binding]; other site 759362003658 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 759362003659 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 759362003660 ABC transporter; Region: ABC_tran_2; pfam12848 759362003661 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 759362003662 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 759362003663 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 759362003664 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 759362003665 PAS domain; Region: PAS_9; pfam13426 759362003666 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 759362003667 putative active site [active] 759362003668 heme pocket [chemical binding]; other site 759362003669 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 759362003670 metal binding site [ion binding]; metal-binding site 759362003671 active site 759362003672 I-site; other site 759362003673 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 759362003674 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 759362003675 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 759362003676 catalytic motif [active] 759362003677 Catalytic residue [active] 759362003678 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 759362003679 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362003680 dimer interface [polypeptide binding]; other site 759362003681 conserved gate region; other site 759362003682 putative PBP binding loops; other site 759362003683 ABC-ATPase subunit interface; other site 759362003684 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 759362003685 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 759362003686 Walker A/P-loop; other site 759362003687 ATP binding site [chemical binding]; other site 759362003688 Q-loop/lid; other site 759362003689 ABC transporter signature motif; other site 759362003690 Walker B; other site 759362003691 D-loop; other site 759362003692 H-loop/switch region; other site 759362003693 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 759362003694 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 759362003695 BtpA family; Region: BtpA; cl00440 759362003696 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 759362003697 classical (c) SDRs; Region: SDR_c; cd05233 759362003698 NAD(P) binding site [chemical binding]; other site 759362003699 active site 759362003700 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 759362003701 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 759362003702 N- and C-terminal domain interface [polypeptide binding]; other site 759362003703 putative active site [active] 759362003704 MgATP binding site [chemical binding]; other site 759362003705 catalytic site [active] 759362003706 metal binding site [ion binding]; metal-binding site 759362003707 putative xylulose binding site [chemical binding]; other site 759362003708 putative homodimer interface [polypeptide binding]; other site 759362003709 cytosine deaminase; Provisional; Region: PRK05985 759362003710 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 759362003711 active site 759362003712 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; cl19223 759362003713 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 759362003714 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 759362003715 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 759362003716 cytosine deaminase; Provisional; Region: PRK05985 759362003717 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 759362003718 active site 759362003719 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 759362003720 Lumazine binding domain; Region: Lum_binding; pfam00677 759362003721 Lumazine binding domain; Region: Lum_binding; pfam00677 759362003722 DNA polymerase III subunit chi; Validated; Region: PRK05728 759362003723 multifunctional aminopeptidase A; Provisional; Region: PRK00913 759362003724 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 759362003725 interface (dimer of trimers) [polypeptide binding]; other site 759362003726 Substrate-binding/catalytic site; other site 759362003727 Zn-binding sites [ion binding]; other site 759362003728 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 759362003729 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 759362003730 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 759362003731 Organic solvent tolerance protein; Region: OstA_C; pfam04453 759362003732 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 759362003733 SurA N-terminal domain; Region: SurA_N; pfam09312 759362003734 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 759362003735 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312 759362003736 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759362003737 S-adenosylmethionine binding site [chemical binding]; other site 759362003738 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 759362003739 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cl15270 759362003740 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 759362003741 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759362003742 S-adenosylmethionine binding site [chemical binding]; other site 759362003743 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 759362003744 peptide chain release factor 1; Validated; Region: prfA; PRK00591 759362003745 PCRF domain; Region: PCRF; pfam03462 759362003746 RF-1 domain; Region: RF-1; pfam00472 759362003747 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 759362003748 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 759362003749 proposed active site lysine [active] 759362003750 conserved cys residue [active] 759362003751 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 759362003752 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 759362003753 WHG domain; Region: WHG; pfam13305 759362003754 spermidine/putrescine ABC transporter ATP-binding subunit; Region: potA; TIGR01187 759362003755 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759362003756 Q-loop/lid; other site 759362003757 ABC transporter signature motif; other site 759362003758 Walker B; other site 759362003759 D-loop; other site 759362003760 H-loop/switch region; other site 759362003761 TOBE domain; Region: TOBE_2; pfam08402 759362003762 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 759362003763 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362003764 dimer interface [polypeptide binding]; other site 759362003765 conserved gate region; other site 759362003766 putative PBP binding loops; other site 759362003767 ABC-ATPase subunit interface; other site 759362003768 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 759362003769 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362003770 dimer interface [polypeptide binding]; other site 759362003771 conserved gate region; other site 759362003772 putative PBP binding loops; other site 759362003773 ABC-ATPase subunit interface; other site 759362003774 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 759362003775 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 759362003776 23S rRNA interface [nucleotide binding]; other site 759362003777 L3 interface [polypeptide binding]; other site 759362003778 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 759362003779 active site 759362003780 Zn binding site [ion binding]; other site 759362003781 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 759362003782 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 759362003783 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 759362003784 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 759362003785 thiamine phosphate binding site [chemical binding]; other site 759362003786 active site 759362003787 pyrophosphate binding site [ion binding]; other site 759362003788 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 759362003789 putative coenzyme Q binding site [chemical binding]; other site 759362003790 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 759362003791 active site 759362003792 Helix-turn-helix domain; Region: HTH_38; pfam13936 759362003793 GMP synthase; Reviewed; Region: guaA; PRK00074 759362003794 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 759362003795 AMP/PPi binding site [chemical binding]; other site 759362003796 candidate oxyanion hole; other site 759362003797 catalytic triad [active] 759362003798 potential glutamine specificity residues [chemical binding]; other site 759362003799 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 759362003800 ATP Binding subdomain [chemical binding]; other site 759362003801 Ligand Binding sites [chemical binding]; other site 759362003802 Dimerization subdomain; other site 759362003803 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 759362003804 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 759362003805 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 759362003806 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 759362003807 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 759362003808 FMN binding site [chemical binding]; other site 759362003809 active site 759362003810 catalytic residues [active] 759362003811 substrate binding site [chemical binding]; other site 759362003812 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 759362003813 MMPL family; Region: MMPL; cl14618 759362003814 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 759362003815 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 759362003816 HlyD family secretion protein; Region: HlyD_3; pfam13437 759362003817 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 759362003818 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 759362003819 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 759362003820 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362003821 dimer interface [polypeptide binding]; other site 759362003822 conserved gate region; other site 759362003823 putative PBP binding loops; other site 759362003824 ABC-ATPase subunit interface; other site 759362003825 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 759362003826 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 759362003827 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362003828 dimer interface [polypeptide binding]; other site 759362003829 conserved gate region; other site 759362003830 putative PBP binding loops; other site 759362003831 ABC-ATPase subunit interface; other site 759362003832 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 759362003833 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362003834 Walker A/P-loop; other site 759362003835 ATP binding site [chemical binding]; other site 759362003836 Q-loop/lid; other site 759362003837 ABC transporter signature motif; other site 759362003838 Walker B; other site 759362003839 D-loop; other site 759362003840 H-loop/switch region; other site 759362003841 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362003842 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362003843 Walker A/P-loop; other site 759362003844 ATP binding site [chemical binding]; other site 759362003845 Q-loop/lid; other site 759362003846 ABC transporter signature motif; other site 759362003847 Walker B; other site 759362003848 D-loop; other site 759362003849 H-loop/switch region; other site 759362003850 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362003851 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 759362003852 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl19483 759362003853 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 759362003854 Glucokinase; Region: Glucokinase; cl17310 759362003855 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 759362003856 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 759362003857 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 759362003858 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 759362003859 active site 759362003860 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 759362003861 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 759362003862 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 759362003863 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 759362003864 Uncharacterized conserved protein [Function unknown]; Region: COG2308 759362003865 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 759362003866 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 759362003867 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 759362003868 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 759362003869 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 759362003870 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 759362003871 FeS/SAM binding site; other site 759362003872 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 759362003873 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 759362003874 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 759362003875 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 759362003876 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 759362003877 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 759362003878 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 759362003879 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 759362003880 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 759362003881 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 759362003882 dimer interface [polypeptide binding]; other site 759362003883 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 759362003884 active site 759362003885 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 759362003886 catalytic residues [active] 759362003887 substrate binding site [chemical binding]; other site 759362003888 NAD(P) transhydrogenase beta subunit; Region: PNTB; cl00566 759362003889 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 759362003890 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 759362003891 ligand binding site [chemical binding]; other site 759362003892 homodimer interface [polypeptide binding]; other site 759362003893 NAD(P) binding site [chemical binding]; other site 759362003894 trimer interface B [polypeptide binding]; other site 759362003895 trimer interface A [polypeptide binding]; other site 759362003896 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 759362003897 Peptidase C26; Region: Peptidase_C26; pfam07722 759362003898 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 759362003899 catalytic triad [active] 759362003900 malate synthase G; Provisional; Region: PRK02999 759362003901 active site 759362003902 aminopeptidase N; Provisional; Region: pepN; PRK14015 759362003903 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 759362003904 Zn binding site [ion binding]; other site 759362003905 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 759362003906 catalytic residue [active] 759362003907 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 759362003908 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 759362003909 GatB domain; Region: GatB_Yqey; smart00845 759362003910 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 759362003911 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 759362003912 HSP70 interaction site [polypeptide binding]; other site 759362003913 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 759362003914 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 759362003915 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 759362003916 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 759362003917 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 759362003918 dimerization interface [polypeptide binding]; other site 759362003919 putative DNA binding site [nucleotide binding]; other site 759362003920 putative Zn2+ binding site [ion binding]; other site 759362003921 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 759362003922 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651 759362003923 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 759362003924 metal ion-dependent adhesion site (MIDAS); other site 759362003925 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 759362003926 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 759362003927 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 759362003928 active site 759362003929 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 759362003930 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 759362003931 carboxyltransferase (CT) interaction site; other site 759362003932 biotinylation site [posttranslational modification]; other site 759362003933 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 759362003934 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 759362003935 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 759362003936 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 759362003937 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 759362003938 Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; pfam09923 759362003939 NADH ubiquinone oxidoreductase subunit NDUFA12; Region: NDUFA12; cl01534 759362003940 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 759362003941 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 759362003942 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759362003943 Walker A motif; other site 759362003944 ATP binding site [chemical binding]; other site 759362003945 Walker B motif; other site 759362003946 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 759362003947 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 759362003948 oligomer interface [polypeptide binding]; other site 759362003949 active site residues [active] 759362003950 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 759362003951 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 759362003952 phosphoglucomutase; Region: PLN02307 759362003953 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 759362003954 active site 759362003955 substrate binding site [chemical binding]; other site 759362003956 metal binding site [ion binding]; metal-binding site 759362003957 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 759362003958 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 759362003959 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 759362003960 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 759362003961 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 759362003962 ATP cone domain; Region: ATP-cone; pfam03477 759362003963 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 759362003964 active site 759362003965 catalytic site [active] 759362003966 substrate binding site [chemical binding]; other site 759362003967 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 759362003968 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 759362003969 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 759362003970 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 759362003971 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 759362003972 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 759362003973 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 759362003974 DNA binding residues [nucleotide binding] 759362003975 DNA primase; Validated; Region: dnaG; PRK05667 759362003976 CHC2 zinc finger; Region: zf-CHC2; cl17510 759362003977 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 759362003978 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 759362003979 active site 759362003980 metal binding site [ion binding]; metal-binding site 759362003981 interdomain interaction site; other site 759362003982 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 759362003983 Domain of unknown function DUF21; Region: DUF21; pfam01595 759362003984 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 759362003985 Transporter associated domain; Region: CorC_HlyC; smart01091 759362003986 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 759362003987 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 759362003988 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 759362003989 active site 759362003990 intersubunit interactions; other site 759362003991 catalytic residue [active] 759362003992 Protein of unknown function, DUF484; Region: DUF484; cl17449 759362003993 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 759362003994 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 759362003995 active site 759362003996 DNA binding site [nucleotide binding] 759362003997 Int/Topo IB signature motif; other site 759362003998 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 759362003999 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 759362004000 active site 759362004001 HIGH motif; other site 759362004002 nucleotide binding site [chemical binding]; other site 759362004003 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 759362004004 active site 759362004005 KMSKS motif; other site 759362004006 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 759362004007 tRNA binding surface [nucleotide binding]; other site 759362004008 anticodon binding site; other site 759362004009 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 759362004010 Domain of unknown function (DUF697); Region: DUF697; cl12064 759362004011 YcjX-like family, DUF463; Region: DUF463; pfam04317 759362004012 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 759362004013 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 759362004014 dimerization interface 3.5A [polypeptide binding]; other site 759362004015 active site 759362004016 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 759362004017 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 759362004018 Surface antigen; Region: Bac_surface_Ag; pfam01103 759362004019 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 759362004020 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 759362004021 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 759362004022 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 759362004023 Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203 759362004024 Family of unknown function (DUF490); Region: DUF490; pfam04357 759362004025 potential frameshift: common BLAST hit: gi|310816234|ref|YP_003964198.1| DNA processing protein DprA 759362004026 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 759362004027 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 759362004028 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 759362004029 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 759362004030 active site 759362004031 interdomain interaction site; other site 759362004032 putative metal-binding site [ion binding]; other site 759362004033 nucleotide binding site [chemical binding]; other site 759362004034 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 759362004035 domain I; other site 759362004036 DNA binding groove [nucleotide binding] 759362004037 phosphate binding site [ion binding]; other site 759362004038 domain II; other site 759362004039 domain III; other site 759362004040 nucleotide binding site [chemical binding]; other site 759362004041 catalytic site [active] 759362004042 domain IV; other site 759362004043 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 759362004044 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 759362004045 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 759362004046 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 759362004047 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 759362004048 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 759362004049 dimer interface [polypeptide binding]; other site 759362004050 putative CheW interface [polypeptide binding]; other site 759362004051 CheD chemotactic sensory transduction; Region: CheD; cl00810 759362004052 CheB methylesterase; Region: CheB_methylest; pfam01339 759362004053 STAS domain; Region: STAS_2; pfam13466 759362004054 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 759362004055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759362004056 active site 759362004057 phosphorylation site [posttranslational modification] 759362004058 intermolecular recognition site; other site 759362004059 dimerization interface [polypeptide binding]; other site 759362004060 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 759362004061 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 759362004062 putative binding surface; other site 759362004063 active site 759362004064 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 759362004065 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 759362004066 ATP binding site [chemical binding]; other site 759362004067 Mg2+ binding site [ion binding]; other site 759362004068 G-X-G motif; other site 759362004069 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 759362004070 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 759362004071 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 759362004072 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 759362004073 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 759362004074 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759362004075 active site 759362004076 phosphorylation site [posttranslational modification] 759362004077 intermolecular recognition site; other site 759362004078 dimerization interface [polypeptide binding]; other site 759362004079 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 759362004080 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 759362004081 glutaminase active site [active] 759362004082 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 759362004083 dimer interface [polypeptide binding]; other site 759362004084 active site 759362004085 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 759362004086 dimer interface [polypeptide binding]; other site 759362004087 active site 759362004088 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 759362004089 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 759362004090 metal binding site [ion binding]; metal-binding site 759362004091 dimer interface [polypeptide binding]; other site 759362004092 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 759362004093 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 759362004094 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759362004095 homodimer interface [polypeptide binding]; other site 759362004096 catalytic residue [active] 759362004097 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 759362004098 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362004099 Walker A/P-loop; other site 759362004100 ATP binding site [chemical binding]; other site 759362004101 Q-loop/lid; other site 759362004102 ABC transporter signature motif; other site 759362004103 Walker B; other site 759362004104 D-loop; other site 759362004105 H-loop/switch region; other site 759362004106 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362004107 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 759362004108 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362004109 Walker A/P-loop; other site 759362004110 ATP binding site [chemical binding]; other site 759362004111 Q-loop/lid; other site 759362004112 ABC transporter signature motif; other site 759362004113 Walker B; other site 759362004114 D-loop; other site 759362004115 H-loop/switch region; other site 759362004116 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362004117 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 759362004118 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362004119 dimer interface [polypeptide binding]; other site 759362004120 conserved gate region; other site 759362004121 putative PBP binding loops; other site 759362004122 ABC-ATPase subunit interface; other site 759362004123 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 759362004124 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362004125 dimer interface [polypeptide binding]; other site 759362004126 conserved gate region; other site 759362004127 putative PBP binding loops; other site 759362004128 ABC-ATPase subunit interface; other site 759362004129 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 759362004130 putative catalytic residue [active] 759362004131 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 759362004132 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 759362004133 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 759362004134 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; cl19816 759362004135 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; cl19816 759362004136 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 759362004137 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 759362004138 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 759362004139 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 759362004140 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 759362004141 active site 759362004142 Transcriptional regulator [Transcription]; Region: LysR; COG0583 759362004143 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 759362004144 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 759362004145 putative effector binding pocket; other site 759362004146 dimerization interface [polypeptide binding]; other site 759362004147 L-aspartate dehydrogenase; Provisional; Region: PRK13303 759362004148 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 759362004149 Domain of unknown function DUF108; Region: DUF108; pfam01958 759362004150 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 759362004151 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 759362004152 NAD(P) binding site [chemical binding]; other site 759362004153 active site 759362004154 Putative lysophospholipase; Region: Hydrolase_4; cl19140 759362004155 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 759362004156 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 759362004157 DctM-like transporters; Region: DctM; pfam06808 759362004158 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 759362004159 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 759362004160 3-hydroxyacyl-CoA dehydrogenase; Validated; Region: PRK06129 759362004161 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 759362004162 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 759362004163 NIPSNAP; Region: NIPSNAP; pfam07978 759362004164 Cupin domain; Region: Cupin_2; pfam07883 759362004165 Transcriptional regulators [Transcription]; Region: GntR; COG1802 759362004166 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 759362004167 DNA-binding site [nucleotide binding]; DNA binding site 759362004168 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 759362004169 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 759362004170 tetramer interface [polypeptide binding]; other site 759362004171 active site 759362004172 Mg2+/Mn2+ binding site [ion binding]; other site 759362004173 Transcriptional regulators [Transcription]; Region: GntR; COG1802 759362004174 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 759362004175 DNA-binding site [nucleotide binding]; DNA binding site 759362004176 FCD domain; Region: FCD; pfam07729 759362004177 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 759362004178 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 759362004179 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 759362004180 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 759362004181 Transcriptional regulators [Transcription]; Region: GntR; COG1802 759362004182 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 759362004183 DNA-binding site [nucleotide binding]; DNA binding site 759362004184 FCD domain; Region: FCD; pfam07729 759362004185 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 759362004186 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 759362004187 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 759362004188 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 759362004189 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 759362004190 Walker A/P-loop; other site 759362004191 ATP binding site [chemical binding]; other site 759362004192 Q-loop/lid; other site 759362004193 ABC transporter signature motif; other site 759362004194 Walker B; other site 759362004195 D-loop; other site 759362004196 H-loop/switch region; other site 759362004197 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 759362004198 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362004199 dimer interface [polypeptide binding]; other site 759362004200 conserved gate region; other site 759362004201 putative PBP binding loops; other site 759362004202 ABC-ATPase subunit interface; other site 759362004203 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 759362004204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759362004205 putative substrate translocation pore; other site 759362004206 Major Facilitator Superfamily; Region: MFS_1; pfam07690 759362004207 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 759362004208 active site 759362004209 homodimer interface [polypeptide binding]; other site 759362004210 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 759362004211 Phosphate transporter family; Region: PHO4; pfam01384 759362004212 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 759362004213 nudix motif; other site 759362004214 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 759362004215 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759362004216 active site 759362004217 phosphorylation site [posttranslational modification] 759362004218 intermolecular recognition site; other site 759362004219 dimerization interface [polypeptide binding]; other site 759362004220 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759362004221 Walker A motif; other site 759362004222 ATP binding site [chemical binding]; other site 759362004223 Walker B motif; other site 759362004224 arginine finger; other site 759362004225 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 759362004226 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 759362004227 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 759362004228 dimer interface [polypeptide binding]; other site 759362004229 phosphorylation site [posttranslational modification] 759362004230 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 759362004231 ATP binding site [chemical binding]; other site 759362004232 Mg2+ binding site [ion binding]; other site 759362004233 G-X-G motif; other site 759362004234 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 759362004235 Major Facilitator Superfamily; Region: MFS_1; pfam07690 759362004236 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759362004237 putative substrate translocation pore; other site 759362004238 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 759362004239 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759362004240 Walker A/P-loop; other site 759362004241 ATP binding site [chemical binding]; other site 759362004242 Q-loop/lid; other site 759362004243 ABC transporter signature motif; other site 759362004244 Walker B; other site 759362004245 H-loop/switch region; other site 759362004246 ABC-2 type transporter; Region: ABC2_membrane; cl17235 759362004247 Chain length determinant protein; Region: Wzz; cl19730 759362004248 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524 759362004249 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; cl19502 759362004250 Ceramidase; Region: Ceramidase; pfam05875 759362004251 classical (c) SDRs; Region: SDR_c; cd05233 759362004252 NAD(P) binding site [chemical binding]; other site 759362004253 active site 759362004254 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 759362004255 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 759362004256 active site 759362004257 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 759362004258 Condensation domain; Region: Condensation; cl19241 759362004259 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 759362004260 acyl-activating enzyme (AAE) consensus motif; other site 759362004261 AMP binding site [chemical binding]; other site 759362004262 active site 759362004263 CoA binding site [chemical binding]; other site 759362004264 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 759362004265 Putative lysophospholipase; Region: Hydrolase_4; cl19140 759362004266 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 759362004267 homodimer interface [polypeptide binding]; other site 759362004268 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 759362004269 active site 759362004270 TDP-binding site; other site 759362004271 acceptor substrate-binding pocket; other site 759362004272 Zein-binding; Region: Zein-binding; pfam04576 759362004273 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 759362004274 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 759362004275 putative active site [active] 759362004276 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 759362004277 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 759362004278 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 759362004279 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 759362004280 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 759362004281 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362004282 dimer interface [polypeptide binding]; other site 759362004283 conserved gate region; other site 759362004284 putative PBP binding loops; other site 759362004285 ABC-ATPase subunit interface; other site 759362004286 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 759362004287 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 759362004288 Walker A/P-loop; other site 759362004289 ATP binding site [chemical binding]; other site 759362004290 Q-loop/lid; other site 759362004291 ABC transporter signature motif; other site 759362004292 Walker B; other site 759362004293 D-loop; other site 759362004294 H-loop/switch region; other site 759362004295 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 759362004296 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362004297 dimer interface [polypeptide binding]; other site 759362004298 conserved gate region; other site 759362004299 putative PBP binding loops; other site 759362004300 ABC-ATPase subunit interface; other site 759362004301 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 759362004302 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 759362004303 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 759362004304 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 759362004305 DNA-binding site [nucleotide binding]; DNA binding site 759362004306 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 759362004307 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 759362004308 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 759362004309 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 759362004310 Walker A/P-loop; other site 759362004311 ATP binding site [chemical binding]; other site 759362004312 Q-loop/lid; other site 759362004313 ABC transporter signature motif; other site 759362004314 Walker B; other site 759362004315 D-loop; other site 759362004316 H-loop/switch region; other site 759362004317 TOBE domain; Region: TOBE_2; pfam08402 759362004318 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 759362004319 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 759362004320 active site 759362004321 catalytic site [active] 759362004322 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 759362004323 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 759362004324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362004325 dimer interface [polypeptide binding]; other site 759362004326 conserved gate region; other site 759362004327 putative PBP binding loops; other site 759362004328 ABC-ATPase subunit interface; other site 759362004329 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 759362004330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362004331 dimer interface [polypeptide binding]; other site 759362004332 conserved gate region; other site 759362004333 putative PBP binding loops; other site 759362004334 ABC-ATPase subunit interface; other site 759362004335 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 759362004336 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 759362004337 Transcriptional regulators [Transcription]; Region: PurR; COG1609 759362004338 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 759362004339 DNA binding site [nucleotide binding] 759362004340 domain linker motif; other site 759362004341 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 759362004342 ligand binding site [chemical binding]; other site 759362004343 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 759362004344 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 759362004345 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 759362004346 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 759362004347 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 759362004348 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 759362004349 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 759362004350 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 759362004351 PRC-barrel domain; Region: PRC; pfam05239 759362004352 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 759362004353 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 759362004354 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 759362004355 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 759362004356 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 759362004357 Sulfate transporter family; Region: Sulfate_transp; pfam00916 759362004358 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 759362004359 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 759362004360 NAD(P) binding site [chemical binding]; other site 759362004361 active site 759362004362 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 759362004363 putative active site [active] 759362004364 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 759362004365 lipoyl-biotinyl attachment site [posttranslational modification]; other site 759362004366 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 759362004367 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 759362004368 ATP-grasp domain; Region: ATP-grasp_4; cl17255 759362004369 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 759362004370 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 759362004371 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 759362004372 carboxyltransferase (CT) interaction site; other site 759362004373 biotinylation site [posttranslational modification]; other site 759362004374 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 759362004375 aspartate aminotransferase; Provisional; Region: PRK06107 759362004376 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 759362004377 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759362004378 homodimer interface [polypeptide binding]; other site 759362004379 catalytic residue [active] 759362004380 Transcriptional regulators [Transcription]; Region: PurR; COG1609 759362004381 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 759362004382 DNA binding site [nucleotide binding] 759362004383 domain linker motif; other site 759362004384 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 759362004385 putative dimerization interface [polypeptide binding]; other site 759362004386 putative ligand binding site [chemical binding]; other site 759362004387 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 759362004388 AAA domain; Region: AAA_33; pfam13671 759362004389 ATP-binding site [chemical binding]; other site 759362004390 Gluconate-6-phosphate binding site [chemical binding]; other site 759362004391 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 759362004392 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 759362004393 NAD(P) binding site [chemical binding]; other site 759362004394 active site 759362004395 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 759362004396 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 759362004397 putative ligand binding site [chemical binding]; other site 759362004398 NAD binding site [chemical binding]; other site 759362004399 catalytic site [active] 759362004400 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 759362004401 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 759362004402 putative NAD(P) binding site [chemical binding]; other site 759362004403 catalytic Zn binding site [ion binding]; other site 759362004404 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 759362004405 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 759362004406 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 759362004407 dimerization interface [polypeptide binding]; other site 759362004408 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 759362004409 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 759362004410 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 759362004411 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 759362004412 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 759362004413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362004414 dimer interface [polypeptide binding]; other site 759362004415 conserved gate region; other site 759362004416 putative PBP binding loops; other site 759362004417 ABC-ATPase subunit interface; other site 759362004418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362004419 putative PBP binding loops; other site 759362004420 ABC-ATPase subunit interface; other site 759362004421 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 759362004422 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 759362004423 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 759362004424 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 759362004425 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 759362004426 Walker A/P-loop; other site 759362004427 ATP binding site [chemical binding]; other site 759362004428 Q-loop/lid; other site 759362004429 ABC transporter signature motif; other site 759362004430 Walker B; other site 759362004431 D-loop; other site 759362004432 H-loop/switch region; other site 759362004433 TOBE domain; Region: TOBE_2; pfam08402 759362004434 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 759362004435 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 759362004436 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759362004437 Walker A/P-loop; other site 759362004438 ATP binding site [chemical binding]; other site 759362004439 Q-loop/lid; other site 759362004440 ABC transporter signature motif; other site 759362004441 Walker B; other site 759362004442 D-loop; other site 759362004443 H-loop/switch region; other site 759362004444 TOBE domain; Region: TOBE_2; pfam08402 759362004445 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 759362004446 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362004447 dimer interface [polypeptide binding]; other site 759362004448 conserved gate region; other site 759362004449 putative PBP binding loops; other site 759362004450 ABC-ATPase subunit interface; other site 759362004451 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362004452 dimer interface [polypeptide binding]; other site 759362004453 conserved gate region; other site 759362004454 putative PBP binding loops; other site 759362004455 ABC-ATPase subunit interface; other site 759362004456 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 759362004457 Transcriptional regulator [Transcription]; Region: LysR; COG0583 759362004458 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 759362004459 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 759362004460 dimerization interface [polypeptide binding]; other site 759362004461 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 759362004462 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 759362004463 Trp docking motif [polypeptide binding]; other site 759362004464 active site 759362004465 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 759362004466 CRISPR/Cas system-associated protein Cas3; Region: Cas3_I; cd09639 759362004467 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752 759362004468 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757 759362004469 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cd09689 759362004470 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 759362004471 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 759362004472 NAD(P) binding site [chemical binding]; other site 759362004473 catalytic residues [active] 759362004474 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 759362004475 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 759362004476 Walker A/P-loop; other site 759362004477 ATP binding site [chemical binding]; other site 759362004478 Q-loop/lid; other site 759362004479 ABC transporter signature motif; other site 759362004480 Walker B; other site 759362004481 D-loop; other site 759362004482 H-loop/switch region; other site 759362004483 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 759362004484 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 759362004485 Walker A/P-loop; other site 759362004486 ATP binding site [chemical binding]; other site 759362004487 Q-loop/lid; other site 759362004488 ABC transporter signature motif; other site 759362004489 Walker B; other site 759362004490 D-loop; other site 759362004491 H-loop/switch region; other site 759362004492 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 759362004493 TM-ABC transporter signature motif; other site 759362004494 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 759362004495 TM-ABC transporter signature motif; other site 759362004496 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 759362004497 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 759362004498 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 759362004499 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 759362004500 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 759362004501 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 759362004502 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 759362004503 conserved cys residue [active] 759362004504 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 759362004505 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases; Region: CE4_PuuE_like; cd10979 759362004506 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 759362004507 putative active site [active] 759362004508 putative catalytic site [active] 759362004509 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases; Region: CE4_PuuE_like; cd10979 759362004510 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 759362004511 putative active site [active] 759362004512 putative catalytic site [active] 759362004513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759362004514 putative transporter; Provisional; Region: PRK10504 759362004515 putative substrate translocation pore; other site 759362004516 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 759362004517 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 759362004518 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362004519 dimer interface [polypeptide binding]; other site 759362004520 conserved gate region; other site 759362004521 putative PBP binding loops; other site 759362004522 ABC-ATPase subunit interface; other site 759362004523 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 759362004524 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362004525 dimer interface [polypeptide binding]; other site 759362004526 conserved gate region; other site 759362004527 putative PBP binding loops; other site 759362004528 ABC-ATPase subunit interface; other site 759362004529 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 759362004530 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 759362004531 Walker A/P-loop; other site 759362004532 ATP binding site [chemical binding]; other site 759362004533 Q-loop/lid; other site 759362004534 ABC transporter signature motif; other site 759362004535 Walker B; other site 759362004536 D-loop; other site 759362004537 H-loop/switch region; other site 759362004538 TOBE domain; Region: TOBE_2; pfam08402 759362004539 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 759362004540 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 759362004541 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 759362004542 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 759362004543 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 759362004544 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 759362004545 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 759362004546 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 759362004547 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 759362004548 catalytic triad [active] 759362004549 conserved cis-peptide bond; other site 759362004550 Transcriptional regulator [Transcription]; Region: LysR; COG0583 759362004551 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 759362004552 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 759362004553 dimerization interface [polypeptide binding]; other site 759362004554 LrgB-like family; Region: LrgB; cl00596 759362004555 Predicted membrane protein [Function unknown]; Region: COG4129 759362004556 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 759362004557 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 759362004558 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 759362004559 WHG domain; Region: WHG; pfam13305 759362004560 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 759362004561 NAD(P) binding site [chemical binding]; other site 759362004562 catalytic residues [active] 759362004563 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 759362004564 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362004565 Walker A/P-loop; other site 759362004566 ATP binding site [chemical binding]; other site 759362004567 Q-loop/lid; other site 759362004568 ABC transporter signature motif; other site 759362004569 Walker B; other site 759362004570 D-loop; other site 759362004571 H-loop/switch region; other site 759362004572 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362004573 Walker A/P-loop; other site 759362004574 ATP binding site [chemical binding]; other site 759362004575 Q-loop/lid; other site 759362004576 ABC transporter signature motif; other site 759362004577 Walker B; other site 759362004578 D-loop; other site 759362004579 H-loop/switch region; other site 759362004580 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 759362004581 dipeptidase, putative; Region: dipeptidaselike; TIGR01887 759362004582 active site 759362004583 metal binding site [ion binding]; metal-binding site 759362004584 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 759362004585 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 759362004586 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362004587 dimer interface [polypeptide binding]; other site 759362004588 conserved gate region; other site 759362004589 putative PBP binding loops; other site 759362004590 ABC-ATPase subunit interface; other site 759362004591 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 759362004592 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362004593 dimer interface [polypeptide binding]; other site 759362004594 conserved gate region; other site 759362004595 putative PBP binding loops; other site 759362004596 ABC-ATPase subunit interface; other site 759362004597 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 759362004598 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 759362004599 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 759362004600 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 759362004601 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 759362004602 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 759362004603 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 759362004604 active site 759362004605 DNA binding site [nucleotide binding] 759362004606 Predicted membrane protein [Function unknown]; Region: COG2323 759362004607 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 759362004608 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 759362004609 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 759362004610 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 759362004611 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 759362004612 catalytic site [active] 759362004613 active site 759362004614 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 759362004615 glycogen branching enzyme; Provisional; Region: PRK05402 759362004616 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 759362004617 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 759362004618 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 759362004619 active site 759362004620 catalytic site [active] 759362004621 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 759362004622 glycogen synthase; Provisional; Region: glgA; PRK00654 759362004623 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 759362004624 ADP-binding pocket [chemical binding]; other site 759362004625 homodimer interface [polypeptide binding]; other site 759362004626 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 759362004627 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 759362004628 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 759362004629 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 759362004630 active site 759362004631 catalytic site [active] 759362004632 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 759362004633 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 759362004634 ligand binding site; other site 759362004635 oligomer interface; other site 759362004636 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 759362004637 putative trimer interface [polypeptide binding]; other site 759362004638 putative CoA binding site [chemical binding]; other site 759362004639 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 759362004640 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 759362004641 oxidoreductase; Provisional; Region: PRK06128 759362004642 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 759362004643 NAD(P) binding site [chemical binding]; other site 759362004644 active site 759362004645 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 759362004646 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 759362004647 NAD(P) binding site [chemical binding]; other site 759362004648 active site 759362004649 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 759362004650 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 759362004651 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 759362004652 DNA binding residues [nucleotide binding] 759362004653 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 759362004654 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 759362004655 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 759362004656 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759362004657 putative substrate translocation pore; other site 759362004658 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 759362004659 Transcriptional regulator [Transcription]; Region: IclR; COG1414 759362004660 Bacterial transcriptional regulator; Region: IclR; pfam01614 759362004661 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 759362004662 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362004663 Walker A/P-loop; other site 759362004664 ATP binding site [chemical binding]; other site 759362004665 Q-loop/lid; other site 759362004666 ABC transporter signature motif; other site 759362004667 Walker B; other site 759362004668 D-loop; other site 759362004669 H-loop/switch region; other site 759362004670 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362004671 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 759362004672 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362004673 Walker A/P-loop; other site 759362004674 ATP binding site [chemical binding]; other site 759362004675 Q-loop/lid; other site 759362004676 ABC transporter signature motif; other site 759362004677 Walker B; other site 759362004678 D-loop; other site 759362004679 H-loop/switch region; other site 759362004680 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362004681 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_5; cd08511 759362004682 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 759362004683 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 759362004684 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362004685 dimer interface [polypeptide binding]; other site 759362004686 conserved gate region; other site 759362004687 putative PBP binding loops; other site 759362004688 ABC-ATPase subunit interface; other site 759362004689 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 759362004690 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 759362004691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362004692 dimer interface [polypeptide binding]; other site 759362004693 conserved gate region; other site 759362004694 putative PBP binding loops; other site 759362004695 ABC-ATPase subunit interface; other site 759362004696 hypothetical protein; Provisional; Region: PRK08204 759362004697 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 759362004698 active site 759362004699 Domain of unknown function (DUF927); Region: DUF927; cl12098 759362004700 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 759362004701 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 759362004702 non-specific DNA binding site [nucleotide binding]; other site 759362004703 salt bridge; other site 759362004704 sequence-specific DNA binding site [nucleotide binding]; other site 759362004705 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759362004706 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 759362004707 Walker A motif; other site 759362004708 ATP binding site [chemical binding]; other site 759362004709 Walker B motif; other site 759362004710 arginine finger; other site 759362004711 Peptidase family M41; Region: Peptidase_M41; pfam01434 759362004712 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 759362004713 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 759362004714 catalytic residues [active] 759362004715 catalytic nucleophile [active] 759362004716 Recombinase; Region: Recombinase; pfam07508 759362004717 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 759362004718 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 759362004719 DNA-binding site [nucleotide binding]; DNA binding site 759362004720 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 759362004721 putative catalytic cysteine [active] 759362004722 gamma-glutamyl kinase; Provisional; Region: PRK05429 759362004723 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 759362004724 nucleotide binding site [chemical binding]; other site 759362004725 homotetrameric interface [polypeptide binding]; other site 759362004726 putative phosphate binding site [ion binding]; other site 759362004727 putative allosteric binding site; other site 759362004728 PUA domain; Region: PUA; pfam01472 759362004729 GTPase CgtA; Reviewed; Region: obgE; PRK12299 759362004730 GTP1/OBG; Region: GTP1_OBG; pfam01018 759362004731 Obg GTPase; Region: Obg; cd01898 759362004732 G1 box; other site 759362004733 GTP/Mg2+ binding site [chemical binding]; other site 759362004734 Switch I region; other site 759362004735 G2 box; other site 759362004736 G3 box; other site 759362004737 Switch II region; other site 759362004738 G4 box; other site 759362004739 G5 box; other site 759362004740 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 759362004741 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 759362004742 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 759362004743 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 759362004744 Nucleopolyhedrovirus capsid protein P87; Region: Nucleo_P87; pfam07267 759362004745 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 759362004746 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 759362004747 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 759362004748 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 759362004749 Uncharacterized conserved protein [Function unknown]; Region: COG3791 759362004750 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 759362004751 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 759362004752 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 759362004753 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 759362004754 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759362004755 putative MFS family transporter protein; Provisional; Region: PRK03633 759362004756 putative substrate translocation pore; other site 759362004757 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 759362004758 Protein of unknown function; Region: DUF3971; pfam13116 759362004759 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 759362004760 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 759362004761 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 759362004762 catalytic triad [active] 759362004763 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 759362004764 Peptidase family M23; Region: Peptidase_M23; pfam01551 759362004765 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 759362004766 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 759362004767 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 759362004768 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 759362004769 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 759362004770 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 759362004771 active site 759362004772 LrgB-like family; Region: LrgB; cl00596 759362004773 LrgA family; Region: LrgA; pfam03788 759362004774 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 759362004775 Mg++ binding site [ion binding]; other site 759362004776 putative catalytic motif [active] 759362004777 putative substrate binding site [chemical binding]; other site 759362004778 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 759362004779 MraW methylase family; Region: Methyltransf_5; cl17771 759362004780 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759362004781 S-adenosylmethionine binding site [chemical binding]; other site 759362004782 cell division protein MraZ; Reviewed; Region: PRK00326 759362004783 MraZ protein; Region: MraZ; pfam02381 759362004784 MraZ protein; Region: MraZ; pfam02381 759362004785 Domain of unknown function DUF59; Region: DUF59; pfam01883 759362004786 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 759362004787 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 759362004788 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 759362004789 Sulfate transporter family; Region: Sulfate_transp; cl19250 759362004790 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 759362004791 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 759362004792 Part of AAA domain; Region: AAA_19; pfam13245 759362004793 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 759362004794 pyruvate carboxylase; Reviewed; Region: PRK12999 759362004795 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 759362004796 ATP-grasp domain; Region: ATP-grasp_4; cl17255 759362004797 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 759362004798 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 759362004799 active site 759362004800 catalytic residues [active] 759362004801 metal binding site [ion binding]; metal-binding site 759362004802 homodimer binding site [polypeptide binding]; other site 759362004803 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 759362004804 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 759362004805 carboxyltransferase (CT) interaction site; other site 759362004806 biotinylation site [posttranslational modification]; other site 759362004807 acetyl-CoA synthetase; Provisional; Region: PRK00174 759362004808 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 759362004809 active site 759362004810 CoA binding site [chemical binding]; other site 759362004811 acyl-activating enzyme (AAE) consensus motif; other site 759362004812 AMP binding site [chemical binding]; other site 759362004813 acetate binding site [chemical binding]; other site 759362004814 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 759362004815 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 759362004816 Walker A/P-loop; other site 759362004817 ATP binding site [chemical binding]; other site 759362004818 Q-loop/lid; other site 759362004819 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 759362004820 ABC transporter signature motif; other site 759362004821 Walker B; other site 759362004822 D-loop; other site 759362004823 H-loop/switch region; other site 759362004824 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 759362004825 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 759362004826 cell division protein FtsZ; Validated; Region: PRK09330 759362004827 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 759362004828 nucleotide binding site [chemical binding]; other site 759362004829 SulA interaction site; other site 759362004830 Type III secretion protein (HpaP); Region: HpaP; cl17849 759362004831 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 759362004832 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 759362004833 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 759362004834 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 759362004835 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 759362004836 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 759362004837 active site 759362004838 homodimer interface [polypeptide binding]; other site 759362004839 cell division protein FtsW; Region: ftsW; TIGR02614 759362004840 Predicted flavoproteins [General function prediction only]; Region: COG2081 759362004841 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 759362004842 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 759362004843 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 759362004844 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 759362004845 dimerization interface [polypeptide binding]; other site 759362004846 putative DNA binding site [nucleotide binding]; other site 759362004847 putative Zn2+ binding site [ion binding]; other site 759362004848 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 759362004849 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 759362004850 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 759362004851 Zn2+ binding site [ion binding]; other site 759362004852 Mg2+ binding site [ion binding]; other site 759362004853 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 759362004854 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 759362004855 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 759362004856 putative catalytic site [active] 759362004857 putative phosphate binding site [ion binding]; other site 759362004858 active site 759362004859 metal binding site A [ion binding]; metal-binding site 759362004860 DNA binding site [nucleotide binding] 759362004861 putative AP binding site [nucleotide binding]; other site 759362004862 putative metal binding site B [ion binding]; other site 759362004863 salicylate hydroxylase; Provisional; Region: PRK08163 759362004864 Squalene epoxidase; Region: SE; cl17314 759362004865 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 759362004866 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 759362004867 PIN domain; Region: PIN_3; pfam13470 759362004868 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 759362004869 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 759362004870 putative RNA binding site [nucleotide binding]; other site 759362004871 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759362004872 S-adenosylmethionine binding site [chemical binding]; other site 759362004873 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 759362004874 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 759362004875 metal binding triad; other site 759362004876 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 759362004877 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 759362004878 metal binding triad; other site 759362004879 MoxR-like ATPases [General function prediction only]; Region: COG0714 759362004880 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759362004881 Walker A motif; other site 759362004882 ATP binding site [chemical binding]; other site 759362004883 Walker B motif; other site 759362004884 arginine finger; other site 759362004885 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 759362004886 Protein of unknown function DUF58; Region: DUF58; pfam01882 759362004887 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 759362004888 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 759362004889 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 759362004890 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 759362004891 Protein of unknown function, DUF599; Region: DUF599; pfam04654 759362004892 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 759362004893 active site 759362004894 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 759362004895 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 759362004896 putative dimer interface [polypeptide binding]; other site 759362004897 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 759362004898 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 759362004899 Coenzyme A binding pocket [chemical binding]; other site 759362004900 DNA polymerase I; Provisional; Region: PRK05755 759362004901 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 759362004902 active site 759362004903 metal binding site 1 [ion binding]; metal-binding site 759362004904 putative 5' ssDNA interaction site; other site 759362004905 metal binding site 3; metal-binding site 759362004906 metal binding site 2 [ion binding]; metal-binding site 759362004907 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 759362004908 putative DNA binding site [nucleotide binding]; other site 759362004909 putative metal binding site [ion binding]; other site 759362004910 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 759362004911 active site 759362004912 catalytic site [active] 759362004913 substrate binding site [chemical binding]; other site 759362004914 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 759362004915 active site 759362004916 DNA binding site [nucleotide binding] 759362004917 catalytic site [active] 759362004918 Zinc-finger domain; Region: zf-CHCC; pfam10276 759362004919 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 759362004920 nucleotide binding site/active site [active] 759362004921 HIT family signature motif; other site 759362004922 catalytic residue [active] 759362004923 Core-2/I-Branching enzyme; Region: Branch; pfam02485 759362004924 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 759362004925 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 759362004926 Predicted membrane protein [Function unknown]; Region: COG1971 759362004927 Domain of unknown function DUF; Region: DUF204; pfam02659 759362004928 Domain of unknown function DUF; Region: DUF204; pfam02659 759362004929 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759362004930 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 759362004931 Walker A motif; other site 759362004932 ATP binding site [chemical binding]; other site 759362004933 Walker B motif; other site 759362004934 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 759362004935 sec-independent translocase; Provisional; Region: PRK04654 759362004936 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 759362004937 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 759362004938 HTH domain; Region: HTH_11; pfam08279 759362004939 WYL domain; Region: WYL; pfam13280 759362004940 Hint domain; Region: Hint_2; pfam13403 759362004941 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 759362004942 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 759362004943 G1 box; other site 759362004944 putative GEF interaction site [polypeptide binding]; other site 759362004945 GTP/Mg2+ binding site [chemical binding]; other site 759362004946 Switch I region; other site 759362004947 G2 box; other site 759362004948 G3 box; other site 759362004949 Switch II region; other site 759362004950 G4 box; other site 759362004951 G5 box; other site 759362004952 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 759362004953 PBP superfamily domain; Region: PBP_like_2; pfam12849 759362004954 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 759362004955 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 759362004956 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362004957 dimer interface [polypeptide binding]; other site 759362004958 conserved gate region; other site 759362004959 putative PBP binding loops; other site 759362004960 ABC-ATPase subunit interface; other site 759362004961 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 759362004962 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 759362004963 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362004964 dimer interface [polypeptide binding]; other site 759362004965 conserved gate region; other site 759362004966 putative PBP binding loops; other site 759362004967 ABC-ATPase subunit interface; other site 759362004968 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 759362004969 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 759362004970 Walker A/P-loop; other site 759362004971 ATP binding site [chemical binding]; other site 759362004972 Q-loop/lid; other site 759362004973 ABC transporter signature motif; other site 759362004974 Walker B; other site 759362004975 D-loop; other site 759362004976 H-loop/switch region; other site 759362004977 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 759362004978 PhoU domain; Region: PhoU; pfam01895 759362004979 PhoU domain; Region: PhoU; pfam01895 759362004980 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 759362004981 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759362004982 active site 759362004983 phosphorylation site [posttranslational modification] 759362004984 intermolecular recognition site; other site 759362004985 dimerization interface [polypeptide binding]; other site 759362004986 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 759362004987 DNA binding site [nucleotide binding] 759362004988 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759362004989 putative substrate translocation pore; other site 759362004990 Major Facilitator Superfamily; Region: MFS_1; pfam07690 759362004991 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 759362004992 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 759362004993 MgsA AAA+ ATPase C terminal; Region: MgsA_C; cl19688 759362004994 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 759362004995 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362004996 dimer interface [polypeptide binding]; other site 759362004997 conserved gate region; other site 759362004998 putative PBP binding loops; other site 759362004999 ABC-ATPase subunit interface; other site 759362005000 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 759362005001 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362005002 dimer interface [polypeptide binding]; other site 759362005003 conserved gate region; other site 759362005004 putative PBP binding loops; other site 759362005005 ABC-ATPase subunit interface; other site 759362005006 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 759362005007 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 759362005008 Walker A/P-loop; other site 759362005009 ATP binding site [chemical binding]; other site 759362005010 Q-loop/lid; other site 759362005011 ABC transporter signature motif; other site 759362005012 Walker B; other site 759362005013 D-loop; other site 759362005014 H-loop/switch region; other site 759362005015 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 759362005016 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 759362005017 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 759362005018 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 759362005019 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 759362005020 putative active site [active] 759362005021 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 759362005022 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 759362005023 UDP-galactopyranose mutase; Region: GLF; pfam03275 759362005024 Hint domain; Region: Hint_2; pfam13403 759362005025 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 759362005026 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759362005027 S-adenosylmethionine binding site [chemical binding]; other site 759362005028 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 759362005029 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 759362005030 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 759362005031 protein-splicing catalytic site; other site 759362005032 thioester formation/cholesterol transfer; other site 759362005033 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 759362005034 Hint domain; Region: Hint_2; pfam13403 759362005035 H-NS histone family; Region: Histone_HNS; pfam00816 759362005036 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 759362005037 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 759362005038 maltose O-acetyltransferase; Provisional; Region: PRK10092 759362005039 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 759362005040 active site 759362005041 substrate binding site [chemical binding]; other site 759362005042 trimer interface [polypeptide binding]; other site 759362005043 CoA binding site [chemical binding]; other site 759362005044 Putative phage tail protein; Region: Phage-tail_3; pfam13550 759362005045 Phage-related minor tail protein [Function unknown]; Region: COG5281 759362005046 tape measure domain; Region: tape_meas_nterm; TIGR02675 759362005047 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; cl19901 759362005048 Protein of unknown function (DUF3356); Region: DUF3356; pfam11836 759362005049 Phage major tail protein 2; Region: Phage_tail_2; cl11463 759362005050 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 759362005051 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 759362005052 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 759362005053 oligomerization interface [polypeptide binding]; other site 759362005054 Phage portal protein; Region: Phage_portal; pfam04860 759362005055 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 759362005056 Phage Terminase; Region: Terminase_1; cl19862 759362005057 Phage terminase, small subunit; Region: Terminase_4; cl01525 759362005058 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 759362005059 active site 759362005060 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 759362005061 Rnk N-terminus; Region: Rnk_N; pfam14760 759362005062 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 759362005063 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759362005064 active site 759362005065 phosphorylation site [posttranslational modification] 759362005066 intermolecular recognition site; other site 759362005067 dimerization interface [polypeptide binding]; other site 759362005068 Helix-turn-helix domain; Region: HTH_36; pfam13730 759362005069 Endodeoxyribonuclease RusA; Region: RusA; cl01885 759362005070 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 759362005071 MT-A70; Region: MT-A70; cl01947 759362005072 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 759362005073 non-specific DNA binding site [nucleotide binding]; other site 759362005074 salt bridge; other site 759362005075 sequence-specific DNA binding site [nucleotide binding]; other site 759362005076 Uncharacterized conserved protein [Function unknown]; Region: COG4748 759362005077 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 759362005078 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 759362005079 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 759362005080 DNA polymerase III subunit beta; Validated; Region: PRK05643 759362005081 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 759362005082 putative DNA binding surface [nucleotide binding]; other site 759362005083 dimer interface [polypeptide binding]; other site 759362005084 beta-clamp/clamp loader binding surface; other site 759362005085 beta-clamp/translesion DNA polymerase binding surface; other site 759362005086 HD domain; Region: HD_3; cl17350 759362005087 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 759362005088 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 759362005089 dimer interface [polypeptide binding]; other site 759362005090 ssDNA binding site [nucleotide binding]; other site 759362005091 tetramer (dimer of dimers) interface [polypeptide binding]; other site 759362005092 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 759362005093 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 759362005094 active site 759362005095 DNA binding site [nucleotide binding] 759362005096 Int/Topo IB signature motif; other site 759362005097 Protein of unknown function (DUF2948); Region: DUF2948; pfam11164 759362005098 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 759362005099 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 759362005100 NAD binding site [chemical binding]; other site 759362005101 dimerization interface [polypeptide binding]; other site 759362005102 product binding site; other site 759362005103 substrate binding site [chemical binding]; other site 759362005104 zinc binding site [ion binding]; other site 759362005105 catalytic residues [active] 759362005106 Uncharacterized protein family (UPF0262); Region: UPF0262; cl11489 759362005107 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 759362005108 active site 759362005109 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 759362005110 rRNA binding site [nucleotide binding]; other site 759362005111 predicted 30S ribosome binding site; other site 759362005112 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 759362005113 active site 759362005114 dimer interface [polypeptide binding]; other site 759362005115 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 759362005116 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 759362005117 Domain of unknown function (DUF329); Region: DUF329; pfam03884 759362005118 AMP-binding domain protein; Validated; Region: PRK07529 759362005119 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 759362005120 acyl-activating enzyme (AAE) consensus motif; other site 759362005121 AMP binding site [chemical binding]; other site 759362005122 active site 759362005123 CoA binding site [chemical binding]; other site 759362005124 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 759362005125 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 759362005126 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759362005127 Walker A/P-loop; other site 759362005128 ATP binding site [chemical binding]; other site 759362005129 Q-loop/lid; other site 759362005130 ABC transporter signature motif; other site 759362005131 Walker B; other site 759362005132 D-loop; other site 759362005133 H-loop/switch region; other site 759362005134 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 759362005135 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 759362005136 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 759362005137 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 759362005138 dimer interface [polypeptide binding]; other site 759362005139 motif 1; other site 759362005140 active site 759362005141 motif 2; other site 759362005142 motif 3; other site 759362005143 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 759362005144 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 759362005145 Transglycosylase; Region: Transgly; cl19357 759362005146 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 759362005147 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 759362005148 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 759362005149 C-terminal domain interface [polypeptide binding]; other site 759362005150 GSH binding site (G-site) [chemical binding]; other site 759362005151 dimer interface [polypeptide binding]; other site 759362005152 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 759362005153 N-terminal domain interface [polypeptide binding]; other site 759362005154 dimer interface [polypeptide binding]; other site 759362005155 substrate binding pocket (H-site) [chemical binding]; other site 759362005156 epoxyqueuosine reductase; Region: TIGR00276 759362005157 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 759362005158 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 759362005159 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 759362005160 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 759362005161 dimer interface [polypeptide binding]; other site 759362005162 active site 759362005163 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 759362005164 catalytic residues [active] 759362005165 substrate binding site [chemical binding]; other site 759362005166 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 759362005167 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 759362005168 aromatic amino acid exporter; Provisional; Region: PRK11689 759362005169 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 759362005170 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 759362005171 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 759362005172 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 759362005173 homotrimer interaction site [polypeptide binding]; other site 759362005174 putative active site [active] 759362005175 Creatinine amidohydrolase; Region: Creatininase; pfam02633 759362005176 cytosine deaminase-like protein; Validated; Region: PRK07583 759362005177 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 759362005178 active site 759362005179 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 759362005180 FAD binding domain; Region: FAD_binding_4; pfam01565 759362005181 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 759362005182 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 759362005183 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 759362005184 Walker A/P-loop; other site 759362005185 ATP binding site [chemical binding]; other site 759362005186 Q-loop/lid; other site 759362005187 ABC transporter signature motif; other site 759362005188 Walker B; other site 759362005189 D-loop; other site 759362005190 H-loop/switch region; other site 759362005191 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362005192 dimer interface [polypeptide binding]; other site 759362005193 conserved gate region; other site 759362005194 putative PBP binding loops; other site 759362005195 ABC-ATPase subunit interface; other site 759362005196 SnoaL-like domain; Region: SnoaL_2; pfam12680 759362005197 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 759362005198 EamA-like transporter family; Region: EamA; pfam00892 759362005199 EamA-like transporter family; Region: EamA; pfam00892 759362005200 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 759362005201 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 759362005202 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 759362005203 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 759362005204 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 759362005205 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 759362005206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362005207 dimer interface [polypeptide binding]; other site 759362005208 conserved gate region; other site 759362005209 putative PBP binding loops; other site 759362005210 ABC-ATPase subunit interface; other site 759362005211 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 759362005212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362005213 dimer interface [polypeptide binding]; other site 759362005214 conserved gate region; other site 759362005215 putative PBP binding loops; other site 759362005216 ABC-ATPase subunit interface; other site 759362005217 Argininosuccinate lyase [Amino acid transport and metabolism]; Region: ArgH; COG0165 759362005218 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 759362005219 active sites [active] 759362005220 tetramer interface [polypeptide binding]; other site 759362005221 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 759362005222 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 759362005223 Walker A/P-loop; other site 759362005224 ATP binding site [chemical binding]; other site 759362005225 Q-loop/lid; other site 759362005226 ABC transporter signature motif; other site 759362005227 Walker B; other site 759362005228 D-loop; other site 759362005229 H-loop/switch region; other site 759362005230 TOBE domain; Region: TOBE_2; pfam08402 759362005231 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 759362005232 substrate binding site [chemical binding]; other site 759362005233 ATP binding site [chemical binding]; other site 759362005234 Cation transport protein; Region: TrkH; cl17365 759362005235 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 759362005236 Cation transport protein; Region: TrkH; cl17365 759362005237 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 759362005238 TrkA-N domain; Region: TrkA_N; pfam02254 759362005239 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 759362005240 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 759362005241 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 759362005242 active site 759362005243 HIGH motif; other site 759362005244 dimer interface [polypeptide binding]; other site 759362005245 KMSKS motif; other site 759362005246 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 759362005247 RNA binding surface [nucleotide binding]; other site 759362005248 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 759362005249 metal binding site 2 [ion binding]; metal-binding site 759362005250 putative DNA binding helix; other site 759362005251 metal binding site 1 [ion binding]; metal-binding site 759362005252 dimer interface [polypeptide binding]; other site 759362005253 structural Zn2+ binding site [ion binding]; other site 759362005254 EamA-like transporter family; Region: EamA; pfam00892 759362005255 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 759362005256 EamA-like transporter family; Region: EamA; pfam00892 759362005257 enolase; Provisional; Region: eno; PRK00077 759362005258 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 759362005259 dimer interface [polypeptide binding]; other site 759362005260 metal binding site [ion binding]; metal-binding site 759362005261 substrate binding pocket [chemical binding]; other site 759362005262 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 759362005263 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 759362005264 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 759362005265 Competence protein; Region: Competence; pfam03772 759362005266 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 759362005267 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 759362005268 active site 759362005269 HIGH motif; other site 759362005270 KMSKS motif; other site 759362005271 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 759362005272 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 759362005273 dimer interface [polypeptide binding]; other site 759362005274 active site 759362005275 citrylCoA binding site [chemical binding]; other site 759362005276 NADH binding [chemical binding]; other site 759362005277 cationic pore residues; other site 759362005278 oxalacetate/citrate binding site [chemical binding]; other site 759362005279 coenzyme A binding site [chemical binding]; other site 759362005280 catalytic triad [active] 759362005281 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 759362005282 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 759362005283 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 759362005284 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 759362005285 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 759362005286 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl19935 759362005287 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 759362005288 Transcriptional regulator [Transcription]; Region: LysR; COG0583 759362005289 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 759362005290 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 759362005291 putative effector binding pocket; other site 759362005292 dimerization interface [polypeptide binding]; other site 759362005293 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 759362005294 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 759362005295 dimerization interface [polypeptide binding]; other site 759362005296 ATP binding site [chemical binding]; other site 759362005297 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 759362005298 dimerization interface [polypeptide binding]; other site 759362005299 ATP binding site [chemical binding]; other site 759362005300 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 759362005301 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 759362005302 putative GSH binding site [chemical binding]; other site 759362005303 catalytic residues [active] 759362005304 Cell division protein ZapA; Region: ZapA; pfam05164 759362005305 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 759362005306 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 759362005307 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 759362005308 TPP-binding site [chemical binding]; other site 759362005309 dimer interface [polypeptide binding]; other site 759362005310 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 759362005311 PYR/PP interface [polypeptide binding]; other site 759362005312 dimer interface [polypeptide binding]; other site 759362005313 TPP binding site [chemical binding]; other site 759362005314 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 759362005315 Protein of unknown function (DUF808); Region: DUF808; cl01002 759362005316 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 759362005317 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 759362005318 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 759362005319 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 759362005320 active site 759362005321 (T/H)XGH motif; other site 759362005322 Hint domain; Region: Hint_2; pfam13403 759362005323 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 759362005324 salicylate hydroxylase; Provisional; Region: PRK08163 759362005325 transcription antitermination factor NusB; Region: nusB; TIGR01951 759362005326 putative RNA binding site [nucleotide binding]; other site 759362005327 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 759362005328 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 759362005329 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 759362005330 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 759362005331 nucleoside/Zn binding site; other site 759362005332 dimer interface [polypeptide binding]; other site 759362005333 catalytic motif [active] 759362005334 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 759362005335 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 759362005336 RNA binding surface [nucleotide binding]; other site 759362005337 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 759362005338 active site 759362005339 putative protease; Region: PHA00666 759362005340 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 759362005341 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 759362005342 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 759362005343 Protein of unknown function (DUF2927); Region: DUF2927; pfam11150 759362005344 Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like_u1; cd03408 759362005345 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 759362005346 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 759362005347 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 759362005348 putative substrate binding site [chemical binding]; other site 759362005349 putative ATP binding site [chemical binding]; other site 759362005350 D-tyrosyl-tRNA(Tyr) deacylase; Provisional; Region: PRK05273 759362005351 putative active site [active] 759362005352 dimerization interface [polypeptide binding]; other site 759362005353 putative tRNAtyr binding site [nucleotide binding]; other site 759362005354 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 759362005355 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 759362005356 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 759362005357 homodimer interface [polypeptide binding]; other site 759362005358 NADP binding site [chemical binding]; other site 759362005359 substrate binding site [chemical binding]; other site 759362005360 FtsH Extracellular; Region: FtsH_ext; pfam06480 759362005361 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 759362005362 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759362005363 Walker A motif; other site 759362005364 ATP binding site [chemical binding]; other site 759362005365 Walker B motif; other site 759362005366 arginine finger; other site 759362005367 Peptidase family M41; Region: Peptidase_M41; pfam01434 759362005368 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 759362005369 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 759362005370 Ligand Binding Site [chemical binding]; other site 759362005371 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 759362005372 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 759362005373 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 759362005374 ligand binding site [chemical binding]; other site 759362005375 translocation protein TolB; Provisional; Region: tolB; PRK05137 759362005376 TolB amino-terminal domain; Region: TolB_N; pfam04052 759362005377 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 759362005378 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 759362005379 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 759362005380 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 759362005381 TolR protein; Region: tolR; TIGR02801 759362005382 TolQ protein; Region: tolQ; TIGR02796 759362005383 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 759362005384 active site 759362005385 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 759362005386 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759362005387 Walker A motif; other site 759362005388 ATP binding site [chemical binding]; other site 759362005389 Walker B motif; other site 759362005390 arginine finger; other site 759362005391 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 759362005392 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 759362005393 RuvA N terminal domain; Region: RuvA_N; pfam01330 759362005394 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 759362005395 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 759362005396 active site 759362005397 putative DNA-binding cleft [nucleotide binding]; other site 759362005398 dimer interface [polypeptide binding]; other site 759362005399 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 759362005400 ATP phosphoribosyltransferase; Region: HisG; cl15266 759362005401 ATP phosphoribosyltransferase involved in histidine biosynthesis [Amino acid transport and metabolism]; Region: HisZ; COG3705 759362005402 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295 759362005403 motif 1; other site 759362005404 dimer interface [polypeptide binding]; other site 759362005405 active site 759362005406 motif 2; other site 759362005407 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 759362005408 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 759362005409 dimer interface [polypeptide binding]; other site 759362005410 motif 1; other site 759362005411 active site 759362005412 motif 2; other site 759362005413 motif 3; other site 759362005414 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 759362005415 anticodon binding site; other site 759362005416 SlyX; Region: SlyX; pfam04102 759362005417 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 759362005418 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 759362005419 putative active site [active] 759362005420 putative PHP Thumb interface [polypeptide binding]; other site 759362005421 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 759362005422 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 759362005423 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 759362005424 generic binding surface II; other site 759362005425 generic binding surface I; other site 759362005426 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 759362005427 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 759362005428 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 759362005429 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 759362005430 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825 759362005431 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 759362005432 Predicted membrane protein [Function unknown]; Region: COG3650 759362005433 META domain; Region: META; pfam03724 759362005434 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 759362005435 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 759362005436 active site 759362005437 metal binding site [ion binding]; metal-binding site 759362005438 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 759362005439 Protein of unknown function (DUF952); Region: DUF952; pfam06108 759362005440 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 759362005441 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 759362005442 quinone interaction residues [chemical binding]; other site 759362005443 active site 759362005444 catalytic residues [active] 759362005445 FMN binding site [chemical binding]; other site 759362005446 substrate binding site [chemical binding]; other site 759362005447 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 759362005448 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 759362005449 DNA binding residues [nucleotide binding] 759362005450 putative dimer interface [polypeptide binding]; other site 759362005451 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 759362005452 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 759362005453 DNA binding residues [nucleotide binding] 759362005454 putative dimer interface [polypeptide binding]; other site 759362005455 Sporulation related domain; Region: SPOR; pfam05036 759362005456 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 759362005457 active site 759362005458 adenosine deaminase; Provisional; Region: PRK09358 759362005459 active site 759362005460 phosphopentomutase; Provisional; Region: PRK05362 759362005461 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 759362005462 Putative lysophospholipase; Region: Hydrolase_4; cl19140 759362005463 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 759362005464 GTP-binding protein LepA; Provisional; Region: PRK05433 759362005465 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 759362005466 G1 box; other site 759362005467 putative GEF interaction site [polypeptide binding]; other site 759362005468 GTP/Mg2+ binding site [chemical binding]; other site 759362005469 Switch I region; other site 759362005470 G2 box; other site 759362005471 G3 box; other site 759362005472 Switch II region; other site 759362005473 G4 box; other site 759362005474 G5 box; other site 759362005475 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 759362005476 Elongation Factor G, domain II; Region: EFG_II; pfam14492 759362005477 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 759362005478 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 759362005479 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 759362005480 dimer interface [polypeptide binding]; other site 759362005481 ligand binding site [chemical binding]; other site 759362005482 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 759362005483 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 759362005484 nudix motif; other site 759362005485 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 759362005486 ornithine carbamoyltransferase; Provisional; Region: PRK00779 759362005487 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 759362005488 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 759362005489 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 759362005490 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 759362005491 inhibitor-cofactor binding pocket; inhibition site 759362005492 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759362005493 catalytic residue [active] 759362005494 NLPA lipoprotein; Region: Lipoprotein_9; cl19159 759362005495 CsbD-like; Region: CsbD; cl17424 759362005496 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 759362005497 Aspartase; Region: Aspartase; cd01357 759362005498 active sites [active] 759362005499 tetramer interface [polypeptide binding]; other site 759362005500 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 759362005501 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 759362005502 Coenzyme A binding pocket [chemical binding]; other site 759362005503 Major Facilitator Superfamily; Region: MFS_1; pfam07690 759362005504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759362005505 putative substrate translocation pore; other site 759362005506 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 759362005507 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 759362005508 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 759362005509 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 759362005510 Secretin and TonB N terminus short domain; Region: STN; smart00965 759362005511 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 759362005512 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 759362005513 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 759362005514 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 759362005515 FecR protein; Region: FecR; pfam04773 759362005516 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 759362005517 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 759362005518 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 759362005519 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 759362005520 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 759362005521 putative DNA binding site [nucleotide binding]; other site 759362005522 dimerization interface [polypeptide binding]; other site 759362005523 putative Zn2+ binding site [ion binding]; other site 759362005524 AsnC family; Region: AsnC_trans_reg; pfam01037 759362005525 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 759362005526 DNA-binding domain of Proline dehydrogenase; Region: Pro_dh-DNA_bdg; pfam14850 759362005527 Proline dehydrogenase; Region: Pro_dh; pfam01619 759362005528 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 759362005529 NAD(P) binding site [chemical binding]; other site 759362005530 catalytic residues [active] 759362005531 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 759362005532 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 759362005533 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 759362005534 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 759362005535 putative dimerization interface [polypeptide binding]; other site 759362005536 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 759362005537 FAD binding site [chemical binding]; other site 759362005538 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 759362005539 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 759362005540 active site 759362005541 HIGH motif; other site 759362005542 nucleotide binding site [chemical binding]; other site 759362005543 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 759362005544 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 759362005545 active site 759362005546 KMSKS motif; other site 759362005547 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 759362005548 tRNA binding surface [nucleotide binding]; other site 759362005549 anticodon binding site; other site 759362005550 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 759362005551 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 759362005552 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 759362005553 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759362005554 homodimer interface [polypeptide binding]; other site 759362005555 catalytic residue [active] 759362005556 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 759362005557 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 759362005558 catalytic residue [active] 759362005559 Tyrosine phosphatase family; Region: Y_phosphatase3; cl19170 759362005560 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 759362005561 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 759362005562 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759362005563 Walker A/P-loop; other site 759362005564 ATP binding site [chemical binding]; other site 759362005565 Q-loop/lid; other site 759362005566 ABC transporter signature motif; other site 759362005567 Walker B; other site 759362005568 D-loop; other site 759362005569 H-loop/switch region; other site 759362005570 Aminomethyltransferase folate-binding domain; Region: GCV_T; cl01893 759362005571 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 759362005572 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 759362005573 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 759362005574 active site 759362005575 elongation factor P; Validated; Region: PRK00529 759362005576 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 759362005577 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 759362005578 RNA binding site [nucleotide binding]; other site 759362005579 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 759362005580 RNA binding site [nucleotide binding]; other site 759362005581 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4093 759362005582 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 759362005583 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 759362005584 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 759362005585 putative C-terminal domain interface [polypeptide binding]; other site 759362005586 putative GSH binding site (G-site) [chemical binding]; other site 759362005587 putative dimer interface [polypeptide binding]; other site 759362005588 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 759362005589 dimer interface [polypeptide binding]; other site 759362005590 N-terminal domain interface [polypeptide binding]; other site 759362005591 putative substrate binding pocket (H-site) [chemical binding]; other site 759362005592 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 759362005593 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 759362005594 ATP binding site [chemical binding]; other site 759362005595 Mg2+ binding site [ion binding]; other site 759362005596 G-X-G motif; other site 759362005597 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 759362005598 anchoring element; other site 759362005599 dimer interface [polypeptide binding]; other site 759362005600 ATP binding site [chemical binding]; other site 759362005601 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 759362005602 active site 759362005603 metal binding site [ion binding]; metal-binding site 759362005604 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 759362005605 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 759362005606 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 759362005607 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 759362005608 putative metal binding site [ion binding]; other site 759362005609 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 759362005610 HSP70 interaction site [polypeptide binding]; other site 759362005611 NAD synthetase; Provisional; Region: PRK13981 759362005612 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 759362005613 multimer interface [polypeptide binding]; other site 759362005614 active site 759362005615 catalytic triad [active] 759362005616 protein interface 1 [polypeptide binding]; other site 759362005617 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 759362005618 homodimer interface [polypeptide binding]; other site 759362005619 NAD binding pocket [chemical binding]; other site 759362005620 ATP binding pocket [chemical binding]; other site 759362005621 Mg binding site [ion binding]; other site 759362005622 active-site loop [active] 759362005623 MORN repeat; Region: MORN; cl14787 759362005624 MORN repeat; Region: MORN; cl14787 759362005625 MORN repeat; Region: MORN; cl14787 759362005626 MORN repeat; Region: MORN; cl14787 759362005627 2-isopropylmalate synthase; Validated; Region: PRK00915 759362005628 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 759362005629 active site 759362005630 catalytic residues [active] 759362005631 metal binding site [ion binding]; metal-binding site 759362005632 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 759362005633 Domain of unknown function (DUF4174); Region: DUF4174; pfam13778 759362005634 Protein of unknown function, DUF486; Region: DUF486; cl01236 759362005635 hypothetical protein; Validated; Region: PRK00110 759362005636 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 759362005637 putative active site [active] 759362005638 metal binding site [ion binding]; metal-binding site 759362005639 homodimer binding site [polypeptide binding]; other site 759362005640 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 759362005641 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 759362005642 MgtE intracellular N domain; Region: MgtE_N; smart00924 759362005643 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 759362005644 Divalent cation transporter; Region: MgtE; cl00786 759362005645 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 759362005646 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 759362005647 putative DNA binding site [nucleotide binding]; other site 759362005648 putative Zn2+ binding site [ion binding]; other site 759362005649 AsnC family; Region: AsnC_trans_reg; pfam01037 759362005650 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 759362005651 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759362005652 putative substrate translocation pore; other site 759362005653 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318 759362005654 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 759362005655 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 759362005656 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 759362005657 active site 759362005658 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 759362005659 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 759362005660 non-specific DNA binding site [nucleotide binding]; other site 759362005661 salt bridge; other site 759362005662 sequence-specific DNA binding site [nucleotide binding]; other site 759362005663 Transcriptional regulator [Transcription]; Region: LysR; COG0583 759362005664 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 759362005665 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 759362005666 dimerization interface [polypeptide binding]; other site 759362005667 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 759362005668 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 759362005669 Predicted flavoprotein [General function prediction only]; Region: COG0431 759362005670 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 759362005671 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 759362005672 glutamine synthetase; Provisional; Region: glnA; PRK09469 759362005673 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 759362005674 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 759362005675 adenylosuccinate lyase; Provisional; Region: PRK07492 759362005676 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 759362005677 tetramer interface [polypeptide binding]; other site 759362005678 active site 759362005679 Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536 759362005680 FliG N-terminal domain; Region: FliG_N; pfam14842 759362005681 FliG middle domain; Region: FliG_M; pfam14841 759362005682 FliG C-terminal domain; Region: FliG_C; pfam01706 759362005683 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 759362005684 putative acyl-acceptor binding pocket; other site 759362005685 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 759362005686 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 759362005687 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 759362005688 Sporulation related domain; Region: SPOR; pfam05036 759362005689 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 759362005690 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 759362005691 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 759362005692 active site 759362005693 HIGH motif; other site 759362005694 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 759362005695 KMSK motif region; other site 759362005696 tRNA binding surface [nucleotide binding]; other site 759362005697 DALR anticodon binding domain; Region: DALR_1; smart00836 759362005698 anticodon binding site; other site 759362005699 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 759362005700 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 759362005701 ATP binding site [chemical binding]; other site 759362005702 Mg++ binding site [ion binding]; other site 759362005703 motif III; other site 759362005704 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 759362005705 nucleotide binding region [chemical binding]; other site 759362005706 ATP-binding site [chemical binding]; other site 759362005707 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 759362005708 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 759362005709 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 759362005710 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 759362005711 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 759362005712 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 759362005713 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 759362005714 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 759362005715 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 759362005716 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 759362005717 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 759362005718 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 759362005719 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 759362005720 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 759362005721 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 759362005722 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 759362005723 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 759362005724 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 759362005725 NADH dehydrogenase subunit G; Validated; Region: PRK09130 759362005726 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 759362005727 catalytic loop [active] 759362005728 iron binding site [ion binding]; other site 759362005729 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 759362005730 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 759362005731 molybdopterin cofactor binding site; other site 759362005732 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 759362005733 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 759362005734 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 759362005735 SLBB domain; Region: SLBB; pfam10531 759362005736 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 759362005737 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 759362005738 Thioredoxin-like [2Fe-2S] ferredoxin; Region: 2Fe-2S_thioredx; pfam01257 759362005739 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 759362005740 putative dimer interface [polypeptide binding]; other site 759362005741 [2Fe-2S] cluster binding site [ion binding]; other site 759362005742 NADH dehydrogenase subunit D; Validated; Region: PRK06075 759362005743 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 759362005744 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 759362005745 NADH dehydrogenase subunit B; Validated; Region: PRK06411 759362005746 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 759362005747 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 759362005748 phosphoglycolate phosphatase; Provisional; Region: PRK13222 759362005749 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 759362005750 motif II; other site 759362005751 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 759362005752 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 759362005753 Substrate binding site; other site 759362005754 Mg++ binding site; other site 759362005755 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 759362005756 active site 759362005757 substrate binding site [chemical binding]; other site 759362005758 CoA binding site [chemical binding]; other site 759362005759 A new structural DNA glycosylase; Region: AlkD_like; cl11434 759362005760 active site 759362005761 Methyltransferase domain; Region: Methyltransf_23; pfam13489 759362005762 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 759362005763 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 759362005764 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 759362005765 heme binding site [chemical binding]; other site 759362005766 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 759362005767 heme binding site [chemical binding]; other site 759362005768 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 759362005769 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 759362005770 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 759362005771 dimerization interface [polypeptide binding]; other site 759362005772 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 759362005773 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 759362005774 N-terminal plug; other site 759362005775 ligand-binding site [chemical binding]; other site 759362005776 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 759362005777 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 759362005778 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 759362005779 active site residue [active] 759362005780 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 759362005781 active site residue [active] 759362005782 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 759362005783 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 759362005784 Walker A/P-loop; other site 759362005785 ATP binding site [chemical binding]; other site 759362005786 Q-loop/lid; other site 759362005787 ABC transporter signature motif; other site 759362005788 Walker B; other site 759362005789 D-loop; other site 759362005790 H-loop/switch region; other site 759362005791 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362005792 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362005793 dimer interface [polypeptide binding]; other site 759362005794 conserved gate region; other site 759362005795 ABC-ATPase subunit interface; other site 759362005796 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 759362005797 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 759362005798 substrate binding site [chemical binding]; other site 759362005799 THF binding site; other site 759362005800 zinc-binding site [ion binding]; other site 759362005801 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 759362005802 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362005803 Walker A/P-loop; other site 759362005804 ATP binding site [chemical binding]; other site 759362005805 Q-loop/lid; other site 759362005806 ABC transporter signature motif; other site 759362005807 Walker B; other site 759362005808 D-loop; other site 759362005809 H-loop/switch region; other site 759362005810 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 759362005811 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362005812 Walker A/P-loop; other site 759362005813 ATP binding site [chemical binding]; other site 759362005814 Q-loop/lid; other site 759362005815 ABC transporter signature motif; other site 759362005816 Walker B; other site 759362005817 D-loop; other site 759362005818 H-loop/switch region; other site 759362005819 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 759362005820 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 759362005821 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 759362005822 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362005823 dimer interface [polypeptide binding]; other site 759362005824 conserved gate region; other site 759362005825 putative PBP binding loops; other site 759362005826 ABC-ATPase subunit interface; other site 759362005827 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 759362005828 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362005829 dimer interface [polypeptide binding]; other site 759362005830 conserved gate region; other site 759362005831 putative PBP binding loops; other site 759362005832 ABC-ATPase subunit interface; other site 759362005833 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 759362005834 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_5; cd08511 759362005835 Secretin and TonB N terminus short domain; Region: STN; smart00965 759362005836 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 759362005837 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 759362005838 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 759362005839 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 759362005840 FecR protein; Region: FecR; pfam04773 759362005841 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 759362005842 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 759362005843 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 759362005844 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 759362005845 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 759362005846 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 759362005847 Protein of unknown function DUF45; Region: DUF45; pfam01863 759362005848 Transcriptional regulators [Transcription]; Region: GntR; COG1802 759362005849 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 759362005850 DNA-binding site [nucleotide binding]; DNA binding site 759362005851 FCD domain; Region: FCD; pfam07729 759362005852 Hemin uptake protein hemP; Region: hemP; pfam10636 759362005853 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 759362005854 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 759362005855 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 759362005856 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 759362005857 NAD(P) binding site [chemical binding]; other site 759362005858 active site 759362005859 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 759362005860 intersubunit interface [polypeptide binding]; other site 759362005861 active site 759362005862 catalytic residue [active] 759362005863 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 759362005864 NAD(P) binding site [chemical binding]; other site 759362005865 catalytic residues [active] 759362005866 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 759362005867 NAD(P) binding site [chemical binding]; other site 759362005868 Protein of unknown function (DUF330); Region: DUF330; cl01135 759362005869 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 759362005870 mce related protein; Region: MCE; pfam02470 759362005871 mce related protein; Region: MCE; pfam02470 759362005872 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 759362005873 putative active site pocket [active] 759362005874 4-fold oligomerization interface [polypeptide binding]; other site 759362005875 metal binding residues [ion binding]; metal-binding site 759362005876 3-fold/trimer interface [polypeptide binding]; other site 759362005877 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 759362005878 catalytic residues [active] 759362005879 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 759362005880 substrate binding site [chemical binding]; other site 759362005881 glutamase interaction surface [polypeptide binding]; other site 759362005882 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 759362005883 metal binding site [ion binding]; metal-binding site 759362005884 CoA binding domain; Region: CoA_binding; cl17356 759362005885 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 759362005886 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 759362005887 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 759362005888 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 759362005889 EamA-like transporter family; Region: EamA; pfam00892 759362005890 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 759362005891 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 759362005892 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 759362005893 active site 759362005894 dimer interface [polypeptide binding]; other site 759362005895 non-prolyl cis peptide bond; other site 759362005896 insertion regions; other site 759362005897 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 759362005898 catalytic triad [active] 759362005899 conserved cis-peptide bond; other site 759362005900 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 759362005901 homotrimer interaction site [polypeptide binding]; other site 759362005902 putative active site [active] 759362005903 pyrimidine utilization protein D; Region: RutD; TIGR03611 759362005904 Putative lysophospholipase; Region: Hydrolase_4; cl19140 759362005905 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 759362005906 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 759362005907 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 759362005908 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 759362005909 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 759362005910 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 759362005911 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 759362005912 putative trimer interface [polypeptide binding]; other site 759362005913 putative CoA binding site [chemical binding]; other site 759362005914 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 759362005915 inhibitor-cofactor binding pocket; inhibition site 759362005916 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759362005917 catalytic residue [active] 759362005918 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 759362005919 Rhamnan synthesis protein F; Region: RgpF; pfam05045 759362005920 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 759362005921 EamA-like transporter family; Region: EamA; pfam00892 759362005922 EamA-like transporter family; Region: EamA; pfam00892 759362005923 nuc_hydro_CeIAG: Nucleoside hydrolases similar to the inosine-adenosine-guanosine-preferring nucleoside hydrolase from Caenorhabditis elegans. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_CeIAG; cd02649 759362005924 active site 759362005925 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 759362005926 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 759362005927 putative ligand binding site [chemical binding]; other site 759362005928 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 759362005929 TM-ABC transporter signature motif; other site 759362005930 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 759362005931 TM-ABC transporter signature motif; other site 759362005932 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 759362005933 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 759362005934 Walker A/P-loop; other site 759362005935 ATP binding site [chemical binding]; other site 759362005936 Q-loop/lid; other site 759362005937 ABC transporter signature motif; other site 759362005938 Walker B; other site 759362005939 D-loop; other site 759362005940 H-loop/switch region; other site 759362005941 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 759362005942 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 759362005943 Walker A/P-loop; other site 759362005944 ATP binding site [chemical binding]; other site 759362005945 Q-loop/lid; other site 759362005946 ABC transporter signature motif; other site 759362005947 Walker B; other site 759362005948 D-loop; other site 759362005949 H-loop/switch region; other site 759362005950 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 759362005951 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 759362005952 putative metal binding site [ion binding]; other site 759362005953 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 759362005954 active site 759362005955 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 759362005956 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 759362005957 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 759362005958 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362005959 dimer interface [polypeptide binding]; other site 759362005960 conserved gate region; other site 759362005961 putative PBP binding loops; other site 759362005962 ABC-ATPase subunit interface; other site 759362005963 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 759362005964 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759362005965 Walker A/P-loop; other site 759362005966 ATP binding site [chemical binding]; other site 759362005967 Q-loop/lid; other site 759362005968 ABC transporter signature motif; other site 759362005969 Walker B; other site 759362005970 D-loop; other site 759362005971 H-loop/switch region; other site 759362005972 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 759362005973 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 759362005974 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 759362005975 Protein of unknown function, DUF481; Region: DUF481; pfam04338 759362005976 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 759362005977 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 759362005978 NAD(P) binding site [chemical binding]; other site 759362005979 active site 759362005980 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 759362005981 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 759362005982 ATP binding site [chemical binding]; other site 759362005983 Mg2+ binding site [ion binding]; other site 759362005984 G-X-G motif; other site 759362005985 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 759362005986 ATP binding site [chemical binding]; other site 759362005987 MutL C terminal dimerization domain; Region: MutL_C; pfam08676 759362005988 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 759362005989 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 759362005990 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 759362005991 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 759362005992 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 759362005993 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 759362005994 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 759362005995 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 759362005996 purine monophosphate binding site [chemical binding]; other site 759362005997 dimer interface [polypeptide binding]; other site 759362005998 putative catalytic residues [active] 759362005999 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 759362006000 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 759362006001 16S rRNA methyltransferase B; Provisional; Region: PRK10901 759362006002 NusB family; Region: NusB; pfam01029 759362006003 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759362006004 S-adenosylmethionine binding site [chemical binding]; other site 759362006005 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 759362006006 Predicted esterase [General function prediction only]; Region: COG0400 759362006007 Serine hydrolase (FSH1); Region: FSH1; pfam03959 759362006008 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 759362006009 Zn binding site [ion binding]; other site 759362006010 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 759362006011 Zn binding site [ion binding]; other site 759362006012 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 759362006013 NAD binding site [chemical binding]; other site 759362006014 catalytic residues [active] 759362006015 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 759362006016 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 759362006017 dimer interface [polypeptide binding]; other site 759362006018 decamer (pentamer of dimers) interface [polypeptide binding]; other site 759362006019 catalytic triad [active] 759362006020 recombination protein F; Reviewed; Region: recF; PRK00064 759362006021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759362006022 Walker A/P-loop; other site 759362006023 ATP binding site [chemical binding]; other site 759362006024 Q-loop/lid; other site 759362006025 ABC transporter signature motif; other site 759362006026 Walker B; other site 759362006027 D-loop; other site 759362006028 H-loop/switch region; other site 759362006029 DNA polymerase III subunit beta; Validated; Region: PRK05643 759362006030 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 759362006031 putative DNA binding surface [nucleotide binding]; other site 759362006032 dimer interface [polypeptide binding]; other site 759362006033 beta-clamp/clamp loader binding surface; other site 759362006034 beta-clamp/translesion DNA polymerase binding surface; other site 759362006035 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 759362006036 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 759362006037 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 759362006038 DNA binding site [nucleotide binding] 759362006039 catalytic residue [active] 759362006040 H2TH interface [polypeptide binding]; other site 759362006041 putative catalytic residues [active] 759362006042 turnover-facilitating residue; other site 759362006043 intercalation triad [nucleotide binding]; other site 759362006044 8OG recognition residue [nucleotide binding]; other site 759362006045 putative reading head residues; other site 759362006046 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 759362006047 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 759362006048 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 759362006049 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759362006050 S-adenosylmethionine binding site [chemical binding]; other site 759362006051 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 759362006052 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 759362006053 active site 759362006054 ATP binding site [chemical binding]; other site 759362006055 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 759362006056 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 759362006057 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 759362006058 Rod binding protein; Region: Rod-binding; pfam10135 759362006059 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 759362006060 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 759362006061 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 759362006062 Flagellar protein FlaF; Region: FlaF; cl11454 759362006063 Flagellar protein FlbT; Region: FlbT; pfam07378 759362006064 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 759362006065 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 759362006066 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 759362006067 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 759362006068 Walker A motif; other site 759362006069 ATP binding site [chemical binding]; other site 759362006070 Walker B motif; other site 759362006071 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12627 759362006072 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 759362006073 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 759362006074 flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12632 759362006075 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 759362006076 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 759362006077 Bacterial export proteins, family 3; Region: Bac_export_3; pfam01313 759362006078 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12690 759362006079 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 759362006080 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 759362006081 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 759362006082 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 759362006083 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 759362006084 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 759362006085 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 759362006086 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 759362006087 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 759362006088 Geminin; Region: Geminin; pfam07412 759362006089 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 759362006090 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 759362006091 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 759362006092 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 759362006093 N-acetyl-D-glucosamine binding site [chemical binding]; other site 759362006094 flagellar motor protein MotA; Validated; Region: PRK09110 759362006095 Uncharacterized conserved protein [Function unknown]; Region: COG3334 759362006096 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 759362006097 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 759362006098 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 759362006099 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 759362006100 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 759362006101 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 759362006102 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 759362006103 Flagellar P-ring protein; Region: FlgI; pfam02119 759362006104 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008 759362006105 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 759362006106 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521 759362006107 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 759362006108 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 759362006109 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 759362006110 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 759362006111 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 759362006112 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 759362006113 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 759362006114 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 759362006115 ligand binding site [chemical binding]; other site 759362006116 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 759362006117 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 759362006118 active site 759362006119 dimer interface [polypeptide binding]; other site 759362006120 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 759362006121 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 759362006122 active site 759362006123 FMN binding site [chemical binding]; other site 759362006124 substrate binding site [chemical binding]; other site 759362006125 3Fe-4S cluster binding site [ion binding]; other site 759362006126 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 759362006127 domain interface; other site 759362006128 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 759362006129 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 759362006130 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 759362006131 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 759362006132 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 759362006133 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 759362006134 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 759362006135 putative NAD(P) binding site [chemical binding]; other site 759362006136 active site 759362006137 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 759362006138 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 759362006139 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 759362006140 Integral membrane protein (DUF2244); Region: DUF2244; pfam10003 759362006141 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 759362006142 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 759362006143 Subunit I/III interface [polypeptide binding]; other site 759362006144 D-pathway; other site 759362006145 Subunit I/VIIc interface [polypeptide binding]; other site 759362006146 Subunit I/IV interface [polypeptide binding]; other site 759362006147 Subunit I/II interface [polypeptide binding]; other site 759362006148 Low-spin heme (heme a) binding site [chemical binding]; other site 759362006149 Subunit I/VIIa interface [polypeptide binding]; other site 759362006150 Subunit I/VIa interface [polypeptide binding]; other site 759362006151 Dimer interface; other site 759362006152 Putative water exit pathway; other site 759362006153 Binuclear center (heme a3/CuB) [ion binding]; other site 759362006154 K-pathway; other site 759362006155 Subunit I/Vb interface [polypeptide binding]; other site 759362006156 Putative proton exit pathway; other site 759362006157 Subunit I/VIb interface; other site 759362006158 Subunit I/VIc interface [polypeptide binding]; other site 759362006159 Electron transfer pathway; other site 759362006160 Subunit I/VIIIb interface [polypeptide binding]; other site 759362006161 Subunit I/VIIb interface [polypeptide binding]; other site 759362006162 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 759362006163 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 759362006164 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 759362006165 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 759362006166 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 759362006167 TMP-binding site; other site 759362006168 ATP-binding site [chemical binding]; other site 759362006169 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 759362006170 DNA polymerase III subunit delta'; Validated; Region: PRK08485 759362006171 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 759362006172 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 759362006173 active site 759362006174 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 759362006175 Predicted permeases [General function prediction only]; Region: COG0679 759362006176 H-type lectin domain; Region: H_lectin; pfam09458 759362006177 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 759362006178 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 759362006179 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 759362006180 DNA binding residues [nucleotide binding] 759362006181 dimerization interface [polypeptide binding]; other site 759362006182 homoserine dehydrogenase; Provisional; Region: PRK06349 759362006183 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 759362006184 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 759362006185 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 759362006186 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 759362006187 putative active site [active] 759362006188 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 759362006189 DHH family; Region: DHH; pfam01368 759362006190 DHHA1 domain; Region: DHHA1; pfam02272 759362006191 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 759362006192 nickel responsive regulator; Provisional; Region: PRK02967 759362006193 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 759362006194 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 759362006195 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 759362006196 peptide binding site [polypeptide binding]; other site 759362006197 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 759362006198 Ubiquitin-like proteins; Region: UBQ; cl00155 759362006199 charged pocket; other site 759362006200 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362006201 dimer interface [polypeptide binding]; other site 759362006202 conserved gate region; other site 759362006203 putative PBP binding loops; other site 759362006204 ABC-ATPase subunit interface; other site 759362006205 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 759362006206 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 759362006207 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362006208 dimer interface [polypeptide binding]; other site 759362006209 conserved gate region; other site 759362006210 putative PBP binding loops; other site 759362006211 ABC-ATPase subunit interface; other site 759362006212 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 759362006213 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362006214 Walker A/P-loop; other site 759362006215 ATP binding site [chemical binding]; other site 759362006216 Q-loop/lid; other site 759362006217 ABC transporter signature motif; other site 759362006218 Walker B; other site 759362006219 D-loop; other site 759362006220 H-loop/switch region; other site 759362006221 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362006222 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362006223 Walker A/P-loop; other site 759362006224 ATP binding site [chemical binding]; other site 759362006225 Q-loop/lid; other site 759362006226 ABC transporter signature motif; other site 759362006227 Walker B; other site 759362006228 D-loop; other site 759362006229 H-loop/switch region; other site 759362006230 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 759362006231 putative active site [active] 759362006232 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 759362006233 Protein of unknown function (DUF1190); Region: DUF1190; cl10031 759362006234 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 759362006235 Radical SAM superfamily; Region: Radical_SAM; pfam04055 759362006236 FeS/SAM binding site; other site 759362006237 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 759362006238 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 759362006239 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 759362006240 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 759362006241 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 759362006242 CysD dimerization site [polypeptide binding]; other site 759362006243 G1 box; other site 759362006244 putative GEF interaction site [polypeptide binding]; other site 759362006245 GTP/Mg2+ binding site [chemical binding]; other site 759362006246 Switch I region; other site 759362006247 G2 box; other site 759362006248 G3 box; other site 759362006249 Switch II region; other site 759362006250 G4 box; other site 759362006251 G5 box; other site 759362006252 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 759362006253 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 759362006254 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 759362006255 ligand-binding site [chemical binding]; other site 759362006256 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 759362006257 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 759362006258 Active Sites [active] 759362006259 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 759362006260 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 759362006261 putative active site [active] 759362006262 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 759362006263 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 759362006264 putative active site cavity [active] 759362006265 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 759362006266 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362006267 dimer interface [polypeptide binding]; other site 759362006268 conserved gate region; other site 759362006269 putative PBP binding loops; other site 759362006270 ABC-ATPase subunit interface; other site 759362006271 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 759362006272 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362006273 dimer interface [polypeptide binding]; other site 759362006274 conserved gate region; other site 759362006275 putative PBP binding loops; other site 759362006276 ABC-ATPase subunit interface; other site 759362006277 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 759362006278 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 759362006279 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 759362006280 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 759362006281 Walker A/P-loop; other site 759362006282 ATP binding site [chemical binding]; other site 759362006283 Q-loop/lid; other site 759362006284 ABC transporter signature motif; other site 759362006285 Walker B; other site 759362006286 D-loop; other site 759362006287 H-loop/switch region; other site 759362006288 TOBE domain; Region: TOBE_2; pfam08402 759362006289 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 759362006290 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 759362006291 DNA-binding site [nucleotide binding]; DNA binding site 759362006292 UTRA domain; Region: UTRA; pfam07702 759362006293 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 759362006294 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 759362006295 ABC-2 type transporter; Region: ABC2_membrane; cl17235 759362006296 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 759362006297 active site 759362006298 Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852 759362006299 Transcriptional regulator [Transcription]; Region: LysR; COG0583 759362006300 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 759362006301 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 759362006302 dimerization interface [polypeptide binding]; other site 759362006303 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 759362006304 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 759362006305 Vi polysaccharide export protein VexA; Provisional; Region: PRK15175 759362006306 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 759362006307 Chain length determinant protein; Region: Wzz; cl19730 759362006308 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524 759362006309 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 759362006310 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 759362006311 Walker A/P-loop; other site 759362006312 ATP binding site [chemical binding]; other site 759362006313 Q-loop/lid; other site 759362006314 ABC transporter signature motif; other site 759362006315 Walker B; other site 759362006316 D-loop; other site 759362006317 H-loop/switch region; other site 759362006318 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 759362006319 Methyltransferase FkbM domain; Region: Methyltransf_21; pfam05050 759362006320 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759362006321 S-adenosylmethionine binding site [chemical binding]; other site 759362006322 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 759362006323 active site 759362006324 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 759362006325 GDP-Fucose binding site [chemical binding]; other site 759362006326 Protein of unknown function (DUF2793); Region: DUF2793; pfam10983 759362006327 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 759362006328 Bacterial transcriptional regulator; Region: IclR; pfam01614 759362006329 FAD dependent oxidoreductase; Region: DAO; pfam01266 759362006330 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 759362006331 Hint domain; Region: Hint_2; pfam13403 759362006332 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 759362006333 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 759362006334 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 759362006335 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 759362006336 FeS/SAM binding site; other site 759362006337 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 759362006338 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 759362006339 coenzyme PQQ precursor peptide PqqA; Region: PQQ_syn_pqqA; TIGR02107 759362006340 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 759362006341 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 759362006342 active site residue [active] 759362006343 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 759362006344 active site residue [active] 759362006345 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 759362006346 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 759362006347 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 759362006348 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 759362006349 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 759362006350 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 759362006351 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 759362006352 classical (c) SDRs; Region: SDR_c; cd05233 759362006353 NAD(P) binding site [chemical binding]; other site 759362006354 active site 759362006355 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 759362006356 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 759362006357 DctM-like transporters; Region: DctM; pfam06808 759362006358 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 759362006359 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 759362006360 putative active site [active] 759362006361 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 759362006362 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 759362006363 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 759362006364 Transcriptional regulators [Transcription]; Region: GntR; COG1802 759362006365 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 759362006366 DNA-binding site [nucleotide binding]; DNA binding site 759362006367 FCD domain; Region: FCD; pfam07729 759362006368 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 759362006369 HAMP domain; Region: HAMP; pfam00672 759362006370 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 759362006371 dimer interface [polypeptide binding]; other site 759362006372 phosphorylation site [posttranslational modification] 759362006373 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 759362006374 ATP binding site [chemical binding]; other site 759362006375 Mg2+ binding site [ion binding]; other site 759362006376 G-X-G motif; other site 759362006377 osmolarity response regulator; Provisional; Region: ompR; PRK09468 759362006378 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759362006379 active site 759362006380 phosphorylation site [posttranslational modification] 759362006381 intermolecular recognition site; other site 759362006382 dimerization interface [polypeptide binding]; other site 759362006383 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 759362006384 DNA binding site [nucleotide binding] 759362006385 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 759362006386 active site 759362006387 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 759362006388 Predicted transcriptional regulators [Transcription]; Region: COG1733 759362006389 putative DNA binding site [nucleotide binding]; other site 759362006390 putative Zn2+ binding site [ion binding]; other site 759362006391 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 759362006392 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 759362006393 NAD(P) binding site [chemical binding]; other site 759362006394 active site 759362006395 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 759362006396 active site 759362006397 Transcriptional regulators [Transcription]; Region: MarR; COG1846 759362006398 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 759362006399 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 759362006400 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 759362006401 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 759362006402 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 759362006403 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 759362006404 DNA binding site [nucleotide binding] 759362006405 active site 759362006406 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 759362006407 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 759362006408 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 759362006409 ATP binding site [chemical binding]; other site 759362006410 Mg2+ binding site [ion binding]; other site 759362006411 G-X-G motif; other site 759362006412 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 759362006413 Ribonuclease P; Region: Ribonuclease_P; pfam00825 759362006414 Haemolytic domain; Region: Haemolytic; pfam01809 759362006415 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 759362006416 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 759362006417 Ligand Binding Site [chemical binding]; other site 759362006418 membrane protein insertase; Provisional; Region: PRK01318 759362006419 YidC periplasmic domain; Region: YidC_periplas; pfam14849 759362006420 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 759362006421 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 759362006422 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 759362006423 MOSC domain; Region: MOSC; pfam03473 759362006424 Predicted GTPase [General function prediction only]; Region: COG0218 759362006425 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 759362006426 G1 box; other site 759362006427 GTP/Mg2+ binding site [chemical binding]; other site 759362006428 Switch I region; other site 759362006429 G2 box; other site 759362006430 G3 box; other site 759362006431 Switch II region; other site 759362006432 G4 box; other site 759362006433 G5 box; other site 759362006434 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 759362006435 feedback inhibition sensing region; other site 759362006436 homohexameric interface [polypeptide binding]; other site 759362006437 nucleotide binding site [chemical binding]; other site 759362006438 N-acetyl-L-glutamate binding site [chemical binding]; other site 759362006439 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 759362006440 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 759362006441 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 759362006442 dimerization interface [polypeptide binding]; other site 759362006443 Lysine efflux permease [General function prediction only]; Region: COG1279 759362006444 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 759362006445 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 759362006446 Walker A/P-loop; other site 759362006447 ATP binding site [chemical binding]; other site 759362006448 Q-loop/lid; other site 759362006449 ABC transporter signature motif; other site 759362006450 Walker B; other site 759362006451 D-loop; other site 759362006452 H-loop/switch region; other site 759362006453 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 759362006454 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362006455 dimer interface [polypeptide binding]; other site 759362006456 conserved gate region; other site 759362006457 putative PBP binding loops; other site 759362006458 ABC-ATPase subunit interface; other site 759362006459 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 759362006460 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362006461 conserved gate region; other site 759362006462 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362006463 dimer interface [polypeptide binding]; other site 759362006464 conserved gate region; other site 759362006465 putative PBP binding loops; other site 759362006466 ABC-ATPase subunit interface; other site 759362006467 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 759362006468 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 759362006469 substrate binding pocket [chemical binding]; other site 759362006470 membrane-bound complex binding site; other site 759362006471 hinge residues; other site 759362006472 ATP12 chaperone protein; Region: ATP12; cl02228 759362006473 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 759362006474 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 759362006475 active site 759362006476 motif I; other site 759362006477 motif II; other site 759362006478 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 759362006479 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 759362006480 RNA binding surface [nucleotide binding]; other site 759362006481 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 759362006482 active site 759362006483 CrcB-like protein; Region: CRCB; cl09114 759362006484 recombination factor protein RarA; Reviewed; Region: PRK13342 759362006485 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759362006486 Walker A motif; other site 759362006487 ATP binding site [chemical binding]; other site 759362006488 Walker B motif; other site 759362006489 arginine finger; other site 759362006490 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 759362006491 Autoinducer synthetase; Region: Autoind_synth; cl17404 759362006492 Autoinducer binding domain; Region: Autoind_bind; pfam03472 759362006493 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 759362006494 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 759362006495 DNA binding residues [nucleotide binding] 759362006496 dimerization interface [polypeptide binding]; other site 759362006497 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 759362006498 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 759362006499 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 759362006500 alphaNTD - beta interaction site [polypeptide binding]; other site 759362006501 alphaNTD homodimer interface [polypeptide binding]; other site 759362006502 alphaNTD - beta' interaction site [polypeptide binding]; other site 759362006503 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 759362006504 30S ribosomal protein S11; Validated; Region: PRK05309 759362006505 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 759362006506 adenylate kinase; Reviewed; Region: adk; PRK00279 759362006507 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 759362006508 AMP-binding site [chemical binding]; other site 759362006509 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 759362006510 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 759362006511 SecY translocase; Region: SecY; pfam00344 759362006512 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 759362006513 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 759362006514 23S rRNA binding site [nucleotide binding]; other site 759362006515 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 759362006516 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 759362006517 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 759362006518 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 759362006519 5S rRNA interface [nucleotide binding]; other site 759362006520 L27 interface [polypeptide binding]; other site 759362006521 23S rRNA interface [nucleotide binding]; other site 759362006522 L5 interface [polypeptide binding]; other site 759362006523 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 759362006524 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 759362006525 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 759362006526 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 759362006527 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 759362006528 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 759362006529 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 759362006530 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 759362006531 RNA binding site [nucleotide binding]; other site 759362006532 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 759362006533 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 759362006534 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 759362006535 23S rRNA interface [nucleotide binding]; other site 759362006536 putative translocon interaction site; other site 759362006537 signal recognition particle (SRP54) interaction site; other site 759362006538 L23 interface [polypeptide binding]; other site 759362006539 trigger factor interaction site; other site 759362006540 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 759362006541 23S rRNA interface [nucleotide binding]; other site 759362006542 5S rRNA interface [nucleotide binding]; other site 759362006543 putative antibiotic binding site [chemical binding]; other site 759362006544 L25 interface [polypeptide binding]; other site 759362006545 L27 interface [polypeptide binding]; other site 759362006546 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 759362006547 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 759362006548 G-X-X-G motif; other site 759362006549 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 759362006550 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 759362006551 putative translocon binding site; other site 759362006552 protein-rRNA interface [nucleotide binding]; other site 759362006553 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 759362006554 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 759362006555 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 759362006556 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 759362006557 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 759362006558 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 759362006559 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 759362006560 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 759362006561 elongation factor Tu; Reviewed; Region: PRK00049 759362006562 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 759362006563 G1 box; other site 759362006564 GEF interaction site [polypeptide binding]; other site 759362006565 GTP/Mg2+ binding site [chemical binding]; other site 759362006566 Switch I region; other site 759362006567 G2 box; other site 759362006568 G3 box; other site 759362006569 Switch II region; other site 759362006570 G4 box; other site 759362006571 G5 box; other site 759362006572 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 759362006573 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 759362006574 Antibiotic Binding Site [chemical binding]; other site 759362006575 elongation factor G; Reviewed; Region: PRK00007 759362006576 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 759362006577 G1 box; other site 759362006578 putative GEF interaction site [polypeptide binding]; other site 759362006579 GTP/Mg2+ binding site [chemical binding]; other site 759362006580 Switch I region; other site 759362006581 G2 box; other site 759362006582 G3 box; other site 759362006583 Switch II region; other site 759362006584 G4 box; other site 759362006585 G5 box; other site 759362006586 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 759362006587 Elongation Factor G, domain II; Region: EFG_II; pfam14492 759362006588 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 759362006589 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 759362006590 30S ribosomal protein S7; Validated; Region: PRK05302 759362006591 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 759362006592 S17 interaction site [polypeptide binding]; other site 759362006593 S8 interaction site; other site 759362006594 16S rRNA interaction site [nucleotide binding]; other site 759362006595 streptomycin interaction site [chemical binding]; other site 759362006596 23S rRNA interaction site [nucleotide binding]; other site 759362006597 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 759362006598 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 759362006599 Putative rhamnosyl transferase; Region: Rhamno_transf; pfam11316 759362006600 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 759362006601 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 759362006602 beta and beta' interface [polypeptide binding]; other site 759362006603 beta' and sigma factor interface [polypeptide binding]; other site 759362006604 Zn-binding [ion binding]; other site 759362006605 active site region [active] 759362006606 catalytic site [active] 759362006607 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 759362006608 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 759362006609 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 759362006610 cleft; other site 759362006611 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 759362006612 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 759362006613 G-loop; other site 759362006614 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 759362006615 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 759362006616 DNA binding site [nucleotide binding] 759362006617 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 759362006618 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 759362006619 RPB12 interaction site [polypeptide binding]; other site 759362006620 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl19478 759362006621 RPB1 interaction site [polypeptide binding]; other site 759362006622 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 759362006623 RPB10 interaction site [polypeptide binding]; other site 759362006624 RPB11 interaction site [polypeptide binding]; other site 759362006625 RPB3 interaction site [polypeptide binding]; other site 759362006626 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 759362006627 core dimer interface [polypeptide binding]; other site 759362006628 peripheral dimer interface [polypeptide binding]; other site 759362006629 L10 interface [polypeptide binding]; other site 759362006630 L11 interface [polypeptide binding]; other site 759362006631 putative EF-Tu interaction site [polypeptide binding]; other site 759362006632 putative EF-G interaction site [polypeptide binding]; other site 759362006633 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 759362006634 23S rRNA interface [nucleotide binding]; other site 759362006635 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 759362006636 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 759362006637 mRNA/rRNA interface [nucleotide binding]; other site 759362006638 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 759362006639 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 759362006640 23S rRNA interface [nucleotide binding]; other site 759362006641 L7/L12 interface [polypeptide binding]; other site 759362006642 putative thiostrepton binding site; other site 759362006643 L25 interface [polypeptide binding]; other site 759362006644 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 759362006645 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 759362006646 putative homodimer interface [polypeptide binding]; other site 759362006647 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 759362006648 heterodimer interface [polypeptide binding]; other site 759362006649 homodimer interface [polypeptide binding]; other site 759362006650 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 759362006651 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 759362006652 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 759362006653 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 759362006654 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 759362006655 active site 759362006656 metal binding site [ion binding]; metal-binding site 759362006657 elongation factor Tu; Reviewed; Region: PRK00049 759362006658 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 759362006659 G1 box; other site 759362006660 GEF interaction site [polypeptide binding]; other site 759362006661 GTP/Mg2+ binding site [chemical binding]; other site 759362006662 Switch I region; other site 759362006663 G2 box; other site 759362006664 G3 box; other site 759362006665 Switch II region; other site 759362006666 G4 box; other site 759362006667 G5 box; other site 759362006668 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 759362006669 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 759362006670 Antibiotic Binding Site [chemical binding]; other site 759362006671 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 759362006672 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 759362006673 CAP-like domain; other site 759362006674 active site 759362006675 primary dimer interface [polypeptide binding]; other site 759362006676 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 759362006677 Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588 759362006678 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 759362006679 phosphoglyceromutase; Provisional; Region: PRK05434 759362006680 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 759362006681 Peptidase family M23; Region: Peptidase_M23; pfam01551 759362006682 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 759362006683 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 759362006684 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 759362006685 protein binding site [polypeptide binding]; other site 759362006686 Catalytic dyad [active] 759362006687 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 759362006688 putative active site [active] 759362006689 Ap4A binding site [chemical binding]; other site 759362006690 nudix motif; other site 759362006691 putative metal binding site [ion binding]; other site 759362006692 ribonuclease R; Region: RNase_R; TIGR02063 759362006693 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 759362006694 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 759362006695 RNA binding site [nucleotide binding]; other site 759362006696 short chain dehydrogenase; Provisional; Region: PRK06125 759362006697 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 759362006698 NAD(P) binding site [chemical binding]; other site 759362006699 active site 759362006700 lytic murein transglycosylase; Region: MltB_2; TIGR02283 759362006701 Transglycosylase SLT domain; Region: SLT_2; pfam13406 759362006702 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 759362006703 N-acetyl-D-glucosamine binding site [chemical binding]; other site 759362006704 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 759362006705 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 759362006706 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 759362006707 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 759362006708 metal binding site [ion binding]; metal-binding site 759362006709 dimer interface [polypeptide binding]; other site 759362006710 Predicted membrane protein [Function unknown]; Region: COG2261 759362006711 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 759362006712 Tetrahydrodipicolinate N-succinyltransferase N-terminal; Region: THDPS_N_2; pfam14805 759362006713 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 759362006714 trimer interface [polypeptide binding]; other site 759362006715 active site 759362006716 substrate binding site [chemical binding]; other site 759362006717 CoA binding site [chemical binding]; other site 759362006718 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 759362006719 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 759362006720 FeS/SAM binding site; other site 759362006721 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 759362006722 Cytochrome c; Region: Cytochrom_C; pfam00034 759362006723 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 759362006724 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 759362006725 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 759362006726 Trp docking motif [polypeptide binding]; other site 759362006727 active site 759362006728 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 759362006729 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 759362006730 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 759362006731 active site 759362006732 Peptidase family M50; Region: Peptidase_M50; pfam02163 759362006733 putative substrate binding region [chemical binding]; other site 759362006734 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 759362006735 metal binding site [ion binding]; metal-binding site 759362006736 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 759362006737 von Willebrand factor type A domain; Region: VWA_2; pfam13519 759362006738 metal ion-dependent adhesion site (MIDAS); other site 759362006739 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 759362006740 FixH; Region: FixH; cl19376 759362006741 MoxR-like ATPases [General function prediction only]; Region: COG0714 759362006742 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759362006743 Walker A motif; other site 759362006744 ATP binding site [chemical binding]; other site 759362006745 Walker B motif; other site 759362006746 arginine finger; other site 759362006747 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 759362006748 Protein of unknown function DUF58; Region: DUF58; pfam01882 759362006749 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 759362006750 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759362006751 Walker A/P-loop; other site 759362006752 ATP binding site [chemical binding]; other site 759362006753 Q-loop/lid; other site 759362006754 ABC transporter signature motif; other site 759362006755 Walker B; other site 759362006756 D-loop; other site 759362006757 H-loop/switch region; other site 759362006758 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 759362006759 ABC-2 type transporter; Region: ABC2_membrane; cl17235 759362006760 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 759362006761 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 759362006762 substrate binding pocket [chemical binding]; other site 759362006763 membrane-bound complex binding site; other site 759362006764 hinge residues; other site 759362006765 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 759362006766 Transmembrane secretion effector; Region: MFS_3; pfam05977 759362006767 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759362006768 putative substrate translocation pore; other site 759362006769 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 759362006770 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 759362006771 ABC-ATPase subunit interface; other site 759362006772 dimer interface [polypeptide binding]; other site 759362006773 putative PBP binding regions; other site 759362006774 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 759362006775 ABC-ATPase subunit interface; other site 759362006776 dimer interface [polypeptide binding]; other site 759362006777 putative PBP binding regions; other site 759362006778 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 759362006779 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 759362006780 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 759362006781 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 759362006782 metal binding site [ion binding]; metal-binding site 759362006783 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 759362006784 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 759362006785 Trp docking motif [polypeptide binding]; other site 759362006786 active site 759362006787 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 759362006788 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 759362006789 Protein of unknown function (DUF563); Region: DUF563; pfam04577 759362006790 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 759362006791 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 759362006792 Walker A/P-loop; other site 759362006793 ATP binding site [chemical binding]; other site 759362006794 Q-loop/lid; other site 759362006795 ABC transporter signature motif; other site 759362006796 Walker B; other site 759362006797 D-loop; other site 759362006798 H-loop/switch region; other site 759362006799 TOBE domain; Region: TOBE_2; pfam08402 759362006800 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 759362006801 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362006802 dimer interface [polypeptide binding]; other site 759362006803 conserved gate region; other site 759362006804 putative PBP binding loops; other site 759362006805 ABC-ATPase subunit interface; other site 759362006806 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 759362006807 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362006808 dimer interface [polypeptide binding]; other site 759362006809 conserved gate region; other site 759362006810 putative PBP binding loops; other site 759362006811 ABC-ATPase subunit interface; other site 759362006812 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 759362006813 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 759362006814 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 759362006815 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 759362006816 active site 759362006817 catalytic site [active] 759362006818 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 759362006819 EamA-like transporter family; Region: EamA; cl17759 759362006820 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 759362006821 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 759362006822 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 759362006823 Transporter associated domain; Region: CorC_HlyC; smart01091 759362006824 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 759362006825 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 759362006826 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 759362006827 Coenzyme A binding pocket [chemical binding]; other site 759362006828 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 759362006829 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 759362006830 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 759362006831 NAD binding site [chemical binding]; other site 759362006832 substrate binding site [chemical binding]; other site 759362006833 homodimer interface [polypeptide binding]; other site 759362006834 active site 759362006835 Cupin domain; Region: Cupin_2; cl17218 759362006836 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 759362006837 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 759362006838 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 759362006839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362006840 dimer interface [polypeptide binding]; other site 759362006841 conserved gate region; other site 759362006842 putative PBP binding loops; other site 759362006843 ABC-ATPase subunit interface; other site 759362006844 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 759362006845 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362006846 dimer interface [polypeptide binding]; other site 759362006847 conserved gate region; other site 759362006848 putative PBP binding loops; other site 759362006849 ABC-ATPase subunit interface; other site 759362006850 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 759362006851 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362006852 Walker A/P-loop; other site 759362006853 ATP binding site [chemical binding]; other site 759362006854 Q-loop/lid; other site 759362006855 ABC transporter signature motif; other site 759362006856 Walker B; other site 759362006857 D-loop; other site 759362006858 H-loop/switch region; other site 759362006859 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362006860 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362006861 Walker A/P-loop; other site 759362006862 ATP binding site [chemical binding]; other site 759362006863 Q-loop/lid; other site 759362006864 ABC transporter signature motif; other site 759362006865 Walker B; other site 759362006866 D-loop; other site 759362006867 H-loop/switch region; other site 759362006868 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362006869 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 759362006870 active site 759362006871 non-prolyl cis peptide bond; other site 759362006872 Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898 759362006873 HemY protein N-terminus; Region: HemY_N; pfam07219 759362006874 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 759362006875 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223 759362006876 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 759362006877 active site 759362006878 UGMP family protein; Validated; Region: PRK09604 759362006879 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 759362006880 Fumble; Region: Fumble; cl17357 759362006881 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 759362006882 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 759362006883 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 759362006884 YciI-like protein; Reviewed; Region: PRK12863 759362006885 EVE domain; Region: EVE; cl00728 759362006886 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 759362006887 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 759362006888 catalytic site [active] 759362006889 putative active site [active] 759362006890 putative substrate binding site [chemical binding]; other site 759362006891 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 759362006892 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 759362006893 OstA-like protein; Region: OstA; pfam03968 759362006894 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 759362006895 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 759362006896 Walker A/P-loop; other site 759362006897 ATP binding site [chemical binding]; other site 759362006898 Q-loop/lid; other site 759362006899 ABC transporter signature motif; other site 759362006900 Walker B; other site 759362006901 D-loop; other site 759362006902 H-loop/switch region; other site 759362006903 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 759362006904 30S subunit binding site; other site 759362006905 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 759362006906 active site 759362006907 phosphorylation site [posttranslational modification] 759362006908 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 759362006909 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 759362006910 substrate binding site [chemical binding]; other site 759362006911 hexamer interface [polypeptide binding]; other site 759362006912 metal binding site [ion binding]; metal-binding site 759362006913 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 759362006914 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 759362006915 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 759362006916 catalytic triad [active] 759362006917 conserved cis-peptide bond; other site 759362006918 Core-2/I-Branching enzyme; Region: Branch; pfam02485 759362006919 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 759362006920 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 759362006921 active site 759362006922 tetramer interface; other site 759362006923 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 759362006924 Ligand binding site; other site 759362006925 oligomer interface; other site 759362006926 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 759362006927 active site 759362006928 ABC-2 type transporter; Region: ABC2_membrane; cl17235 759362006929 hypothetical protein; Provisional; Region: PRK14013 759362006930 hypothetical protein; Reviewed; Region: PRK00024 759362006931 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 759362006932 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 759362006933 MPN+ (JAMM) motif; other site 759362006934 Zinc-binding site [ion binding]; other site 759362006935 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 759362006936 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 759362006937 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 759362006938 nucleotide binding region [chemical binding]; other site 759362006939 ATP-binding site [chemical binding]; other site 759362006940 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 759362006941 SEC-C motif; Region: SEC-C; pfam02810 759362006942 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 759362006943 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 759362006944 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 759362006945 heterotetramer interface [polypeptide binding]; other site 759362006946 active site pocket [active] 759362006947 cleavage site 759362006948 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 759362006949 active site 759362006950 8-oxo-dGMP binding site [chemical binding]; other site 759362006951 nudix motif; other site 759362006952 metal binding site [ion binding]; metal-binding site 759362006953 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 759362006954 FMN binding site [chemical binding]; other site 759362006955 active site 759362006956 substrate binding site [chemical binding]; other site 759362006957 catalytic residue [active] 759362006958 DctM-like transporters; Region: DctM; pfam06808 759362006959 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 759362006960 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 759362006961 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 759362006962 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 759362006963 substrate binding site [chemical binding]; other site 759362006964 THF binding site; other site 759362006965 zinc-binding site [ion binding]; other site 759362006966 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 759362006967 translation initiation factor IF-2; Validated; Region: infB; PRK05306 759362006968 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 759362006969 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 759362006970 G1 box; other site 759362006971 putative GEF interaction site [polypeptide binding]; other site 759362006972 GTP/Mg2+ binding site [chemical binding]; other site 759362006973 Switch I region; other site 759362006974 G2 box; other site 759362006975 G3 box; other site 759362006976 Switch II region; other site 759362006977 G4 box; other site 759362006978 G5 box; other site 759362006979 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 759362006980 Translation-initiation factor 2; Region: IF-2; pfam11987 759362006981 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 759362006982 hypothetical protein; Provisional; Region: PRK09190 759362006983 Protein of unknown function (DUF448); Region: DUF448; pfam04296 759362006984 putative RNA binding cleft [nucleotide binding]; other site 759362006985 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 759362006986 NusA N-terminal domain; Region: NusA_N; pfam08529 759362006987 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 759362006988 RNA binding site [nucleotide binding]; other site 759362006989 homodimer interface [polypeptide binding]; other site 759362006990 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 759362006991 G-X-X-G motif; other site 759362006992 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 759362006993 G-X-X-G motif; other site 759362006994 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 759362006995 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 759362006996 Sm and related proteins; Region: Sm_like; cl00259 759362006997 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 759362006998 putative oligomer interface [polypeptide binding]; other site 759362006999 putative RNA binding site [nucleotide binding]; other site 759362007000 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 759362007001 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 759362007002 Putative lysophospholipase; Region: Hydrolase_4; cl19140 759362007003 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 759362007004 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 759362007005 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759362007006 S-adenosylmethionine binding site [chemical binding]; other site 759362007007 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 759362007008 Transcriptional regulators [Transcription]; Region: MarR; COG1846 759362007009 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 759362007010 putative active site [active] 759362007011 catalytic triad [active] 759362007012 dimer interface [polypeptide binding]; other site 759362007013 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 759362007014 GSH binding site [chemical binding]; other site 759362007015 catalytic residues [active] 759362007016 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 759362007017 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 759362007018 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 759362007019 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 759362007020 ferrochelatase; Reviewed; Region: hemH; PRK00035 759362007021 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 759362007022 C-terminal domain interface [polypeptide binding]; other site 759362007023 active site 759362007024 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 759362007025 active site 759362007026 N-terminal domain interface [polypeptide binding]; other site 759362007027 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 759362007028 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 759362007029 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 759362007030 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 759362007031 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 759362007032 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759362007033 S-adenosylmethionine binding site [chemical binding]; other site 759362007034 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 759362007035 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 759362007036 active site 759362007037 NTP binding site [chemical binding]; other site 759362007038 metal binding triad [ion binding]; metal-binding site 759362007039 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 759362007040 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 759362007041 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 759362007042 dimerization interface [polypeptide binding]; other site 759362007043 domain crossover interface; other site 759362007044 redox-dependent activation switch; other site 759362007045 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 759362007046 nudix motif; other site 759362007047 threonine dehydratase; Validated; Region: PRK08639 759362007048 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 759362007049 tetramer interface [polypeptide binding]; other site 759362007050 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759362007051 catalytic residue [active] 759362007052 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 759362007053 putative Ile/Val binding site [chemical binding]; other site 759362007054 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 759362007055 ANP binding site [chemical binding]; other site 759362007056 Substrate Binding Site II [chemical binding]; other site 759362007057 Substrate Binding Site I [chemical binding]; other site 759362007058 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 759362007059 substrate binding site [chemical binding]; other site 759362007060 dimer interface [polypeptide binding]; other site 759362007061 ATP binding site [chemical binding]; other site 759362007062 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 759362007063 dimer interface [polypeptide binding]; other site 759362007064 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 759362007065 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 759362007066 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 759362007067 HrcA protein C terminal domain; Region: HrcA; pfam01628 759362007068 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 759362007069 active site 759362007070 dimerization interface [polypeptide binding]; other site 759362007071 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 759362007072 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 759362007073 FeS/SAM binding site; other site 759362007074 HemN C-terminal domain; Region: HemN_C; pfam06969 759362007075 ParB-like nuclease domain; Region: ParBc; pfam02195 759362007076 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 759362007077 KorB domain; Region: KorB; pfam08535 759362007078 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 759362007079 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 759362007080 P-loop; other site 759362007081 Magnesium ion binding site [ion binding]; other site 759362007082 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 759362007083 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 759362007084 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 759362007085 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 759362007086 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 759362007087 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 759362007088 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 759362007089 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 759362007090 trmE is a tRNA modification GTPase; Region: trmE; cd04164 759362007091 G1 box; other site 759362007092 GTP/Mg2+ binding site [chemical binding]; other site 759362007093 Switch I region; other site 759362007094 G2 box; other site 759362007095 Switch II region; other site 759362007096 G3 box; other site 759362007097 G5 box; other site 759362007098 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 759362007099 transcription termination factor Rho; Provisional; Region: rho; PRK09376 759362007100 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 759362007101 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 759362007102 RNA binding site [nucleotide binding]; other site 759362007103 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 759362007104 multimer interface [polypeptide binding]; other site 759362007105 Walker A motif; other site 759362007106 ATP binding site [chemical binding]; other site 759362007107 Walker B motif; other site 759362007108 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 759362007109 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 759362007110 CoA-binding site [chemical binding]; other site 759362007111 ATP-binding [chemical binding]; other site 759362007112 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 759362007113 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 759362007114 active site 759362007115 catalytic site [active] 759362007116 substrate binding site [chemical binding]; other site 759362007117 Preprotein translocase subunit SecB; Region: SecB; pfam02556 759362007118 SecA binding site; other site 759362007119 Preprotein binding site; other site 759362007120 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 759362007121 Tim44-like domain; Region: Tim44; pfam04280 759362007122 Smr domain; Region: Smr; pfam01713 759362007123 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 759362007124 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 759362007125 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759362007126 Walker A motif; other site 759362007127 ATP binding site [chemical binding]; other site 759362007128 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 759362007129 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 759362007130 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 759362007131 active site 759362007132 HslU subunit interaction site [polypeptide binding]; other site 759362007133 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 759362007134 active site 759362007135 tetramer interface [polypeptide binding]; other site 759362007136 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 759362007137 catalytic residues [active] 759362007138 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 759362007139 Part of AAA domain; Region: AAA_19; pfam13245 759362007140 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 759362007141 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 759362007142 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 759362007143 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402 759362007144 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 759362007145 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 759362007146 PAS domain; Region: PAS; smart00091 759362007147 PAS fold; Region: PAS_7; pfam12860 759362007148 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 759362007149 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 759362007150 dimer interface [polypeptide binding]; other site 759362007151 phosphorylation site [posttranslational modification] 759362007152 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 759362007153 ATP binding site [chemical binding]; other site 759362007154 Mg2+ binding site [ion binding]; other site 759362007155 G-X-G motif; other site 759362007156 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 759362007157 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759362007158 active site 759362007159 phosphorylation site [posttranslational modification] 759362007160 intermolecular recognition site; other site 759362007161 dimerization interface [polypeptide binding]; other site 759362007162 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 759362007163 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 759362007164 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 759362007165 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 759362007166 Protein of unknown function (DUF2853); Region: DUF2853; pfam11015 759362007167 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 759362007168 EamA-like transporter family; Region: EamA; pfam00892 759362007169 branched-chain amino acid aminotransferase; Validated; Region: PRK07544 759362007170 homodimer interface [polypeptide binding]; other site 759362007171 substrate-cofactor binding pocket; other site 759362007172 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759362007173 catalytic residue [active] 759362007174 Transcriptional regulators [Transcription]; Region: MarR; COG1846 759362007175 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 759362007176 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 759362007177 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759362007178 active site 759362007179 phosphorylation site [posttranslational modification] 759362007180 intermolecular recognition site; other site 759362007181 dimerization interface [polypeptide binding]; other site 759362007182 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 759362007183 DNA binding site [nucleotide binding] 759362007184 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 759362007185 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 759362007186 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl18951 759362007187 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 759362007188 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 759362007189 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759362007190 homodimer interface [polypeptide binding]; other site 759362007191 catalytic residue [active] 759362007192 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 759362007193 Type III secretion protein (HpaP); Region: HpaP; cl17849 759362007194 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 759362007195 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 759362007196 AAA-like domain; Region: AAA_10; pfam12846 759362007197 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 759362007198 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 759362007199 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 759362007200 N-acetyl-D-glucosamine binding site [chemical binding]; other site 759362007201 catalytic residue [active] 759362007202 SPRY domain; Region: SPRY; cl02614 759362007203 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 759362007204 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 759362007205 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 759362007206 putative NAD(P) binding site [chemical binding]; other site 759362007207 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 759362007208 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 759362007209 Walker A/P-loop; other site 759362007210 ATP binding site [chemical binding]; other site 759362007211 Q-loop/lid; other site 759362007212 ABC transporter signature motif; other site 759362007213 Walker B; other site 759362007214 D-loop; other site 759362007215 H-loop/switch region; other site 759362007216 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 759362007217 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 759362007218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362007219 dimer interface [polypeptide binding]; other site 759362007220 conserved gate region; other site 759362007221 putative PBP binding loops; other site 759362007222 ABC-ATPase subunit interface; other site 759362007223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362007224 dimer interface [polypeptide binding]; other site 759362007225 conserved gate region; other site 759362007226 putative PBP binding loops; other site 759362007227 ABC-ATPase subunit interface; other site 759362007228 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 759362007229 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 759362007230 active site 759362007231 metal binding site [ion binding]; metal-binding site 759362007232 hexamer interface [polypeptide binding]; other site 759362007233 Transcriptional regulators [Transcription]; Region: PurR; COG1609 759362007234 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 759362007235 DNA binding site [nucleotide binding] 759362007236 domain linker motif; other site 759362007237 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 759362007238 putative dimerization interface [polypeptide binding]; other site 759362007239 putative ligand binding site [chemical binding]; other site 759362007240 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 759362007241 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 759362007242 catalytic residues [active] 759362007243 Protein of unknown function (DUF721); Region: DUF721; pfam05258 759362007244 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 759362007245 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 759362007246 minor groove reading motif; other site 759362007247 helix-hairpin-helix signature motif; other site 759362007248 substrate binding pocket [chemical binding]; other site 759362007249 active site 759362007250 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 759362007251 DNA binding and oxoG recognition site [nucleotide binding] 759362007252 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 759362007253 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 759362007254 RNA/DNA hybrid binding site [nucleotide binding]; other site 759362007255 active site 759362007256 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 759362007257 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 759362007258 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 759362007259 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 759362007260 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 759362007261 HI0933-like protein; Region: HI0933_like; pfam03486 759362007262 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 759362007263 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 759362007264 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 759362007265 Group 4 capsule polysaccharide formation lipoprotein gfcB; Region: Cap_synth_GfcB; pfam11102 759362007266 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 759362007267 Lipopolysaccharide-assembly; Region: LptE; pfam04390 759362007268 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 759362007269 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 759362007270 HIGH motif; other site 759362007271 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 759362007272 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 759362007273 active site 759362007274 KMSKS motif; other site 759362007275 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 759362007276 tRNA binding surface [nucleotide binding]; other site 759362007277 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 759362007278 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 759362007279 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 759362007280 catalytic residue [active] 759362007281 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 759362007282 putative catalytic site [active] 759362007283 putative phosphate binding site [ion binding]; other site 759362007284 active site 759362007285 metal binding site A [ion binding]; metal-binding site 759362007286 DNA binding site [nucleotide binding] 759362007287 putative AP binding site [nucleotide binding]; other site 759362007288 putative metal binding site B [ion binding]; other site 759362007289 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 759362007290 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759362007291 active site 759362007292 phosphorylation site [posttranslational modification] 759362007293 intermolecular recognition site; other site 759362007294 dimerization interface [polypeptide binding]; other site 759362007295 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 759362007296 DNA binding site [nucleotide binding] 759362007297 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 759362007298 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 759362007299 catalytic residues [active] 759362007300 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 759362007301 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 759362007302 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 759362007303 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 759362007304 [2Fe-2S] cluster binding site [ion binding]; other site 759362007305 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 759362007306 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759362007307 Walker A/P-loop; other site 759362007308 ATP binding site [chemical binding]; other site 759362007309 Q-loop/lid; other site 759362007310 ABC transporter signature motif; other site 759362007311 Walker B; other site 759362007312 D-loop; other site 759362007313 H-loop/switch region; other site 759362007314 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 759362007315 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362007316 dimer interface [polypeptide binding]; other site 759362007317 conserved gate region; other site 759362007318 putative PBP binding loops; other site 759362007319 ABC-ATPase subunit interface; other site 759362007320 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 759362007321 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 759362007322 histone-like DNA-binding protein HU; Region: HU; cd13831 759362007323 dimer interface [polypeptide binding]; other site 759362007324 DNA binding site [nucleotide binding] 759362007325 AMP nucleosidase; Provisional; Region: PRK08292 759362007326 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 759362007327 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 759362007328 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 759362007329 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 759362007330 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 759362007331 active site 759362007332 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 759362007333 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 759362007334 active site 759362007335 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 759362007336 Predicted periplasmic protein (DUF2233); Region: DUF2233; cl19845 759362007337 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 759362007338 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 759362007339 RNA binding site [nucleotide binding]; other site 759362007340 active site 759362007341 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 759362007342 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 759362007343 16S/18S rRNA binding site [nucleotide binding]; other site 759362007344 S13e-L30e interaction site [polypeptide binding]; other site 759362007345 25S rRNA binding site [nucleotide binding]; other site 759362007346 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 759362007347 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 759362007348 RNase E interface [polypeptide binding]; other site 759362007349 trimer interface [polypeptide binding]; other site 759362007350 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 759362007351 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 759362007352 RNase E interface [polypeptide binding]; other site 759362007353 trimer interface [polypeptide binding]; other site 759362007354 active site 759362007355 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 759362007356 putative nucleic acid binding region [nucleotide binding]; other site 759362007357 G-X-X-G motif; other site 759362007358 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 759362007359 RNA binding site [nucleotide binding]; other site 759362007360 domain interface; other site 759362007361 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 759362007362 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 759362007363 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 759362007364 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 759362007365 ATP binding site [chemical binding]; other site 759362007366 Mg2+ binding site [ion binding]; other site 759362007367 G-X-G motif; other site 759362007368 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 759362007369 anchoring element; other site 759362007370 dimer interface [polypeptide binding]; other site 759362007371 ATP binding site [chemical binding]; other site 759362007372 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 759362007373 active site 759362007374 putative metal-binding site [ion binding]; other site 759362007375 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 759362007376 Protein of unknown function (DUF1203); Region: DUF1203; pfam06718 759362007377 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 759362007378 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 759362007379 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 759362007380 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 759362007381 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 759362007382 active site residue [active] 759362007383 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 759362007384 catalytic triad [active] 759362007385 metal binding site [ion binding]; metal-binding site 759362007386 conserved cis-peptide bond; other site 759362007387 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 759362007388 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 759362007389 hypothetical protein; Provisional; Region: PRK09256 759362007390 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 759362007391 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 759362007392 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 759362007393 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 759362007394 YGGT family; Region: YGGT; pfam02325 759362007395 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 759362007396 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 759362007397 ATP binding site [chemical binding]; other site 759362007398 putative Mg++ binding site [ion binding]; other site 759362007399 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 759362007400 nucleotide binding region [chemical binding]; other site 759362007401 ATP-binding site [chemical binding]; other site 759362007402 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 759362007403 HRDC domain; Region: HRDC; pfam00570 759362007404 HRDC domain; Region: HRDC; cl02578 759362007405 Protein of unknown function (DUF328); Region: DUF328; pfam03883 759362007406 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 759362007407 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 759362007408 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759362007409 Walker A/P-loop; other site 759362007410 ATP binding site [chemical binding]; other site 759362007411 Q-loop/lid; other site 759362007412 ABC transporter signature motif; other site 759362007413 Walker B; other site 759362007414 D-loop; other site 759362007415 H-loop/switch region; other site 759362007416 hypothetical protein; Provisional; Region: PRK10621 759362007417 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 759362007418 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 759362007419 active site 759362007420 motif I; other site 759362007421 motif II; other site 759362007422 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 759362007423 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 759362007424 putative ligand binding site [chemical binding]; other site 759362007425 NAD binding site [chemical binding]; other site 759362007426 catalytic site [active] 759362007427 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 759362007428 guanine deaminase; Region: guan_deamin; TIGR02967 759362007429 active site 759362007430 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 759362007431 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 759362007432 NADP binding site [chemical binding]; other site 759362007433 Predicted transcriptional regulators [Transcription]; Region: COG1733 759362007434 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 759362007435 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 759362007436 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 759362007437 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 759362007438 catalytic residue [active] 759362007439 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 759362007440 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 759362007441 ligand binding site [chemical binding]; other site 759362007442 NAD binding site [chemical binding]; other site 759362007443 dimerization interface [polypeptide binding]; other site 759362007444 catalytic site [active] 759362007445 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 759362007446 putative L-serine binding site [chemical binding]; other site 759362007447 Protein of unknown function (DUF1272); Region: DUF1272; cl19740 759362007448 DNA polymerase IV; Provisional; Region: PRK02794 759362007449 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 759362007450 active site 759362007451 DNA binding site [nucleotide binding] 759362007452 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 759362007453 Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_paraslipin; cd08829 759362007454 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 759362007455 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 759362007456 active site 759362007457 dimer interface [polypeptide binding]; other site 759362007458 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 759362007459 Clp amino terminal domain; Region: Clp_N; pfam02861 759362007460 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759362007461 Walker A motif; other site 759362007462 ATP binding site [chemical binding]; other site 759362007463 Walker B motif; other site 759362007464 arginine finger; other site 759362007465 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 759362007466 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759362007467 Walker A motif; other site 759362007468 ATP binding site [chemical binding]; other site 759362007469 Walker B motif; other site 759362007470 arginine finger; other site 759362007471 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 759362007472 TMAO/DMSO reductase; Reviewed; Region: PRK05363 759362007473 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 759362007474 Moco binding site; other site 759362007475 metal coordination site [ion binding]; other site 759362007476 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 759362007477 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 759362007478 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 759362007479 active site 759362007480 Rhamnan synthesis protein F; Region: RgpF; pfam05045 759362007481 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 759362007482 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 759362007483 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759362007484 Walker A/P-loop; other site 759362007485 ATP binding site [chemical binding]; other site 759362007486 Q-loop/lid; other site 759362007487 ABC transporter signature motif; other site 759362007488 Walker B; other site 759362007489 D-loop; other site 759362007490 H-loop/switch region; other site 759362007491 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 759362007492 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 759362007493 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 759362007494 active site 759362007495 substrate binding site [chemical binding]; other site 759362007496 metal binding site [ion binding]; metal-binding site 759362007497 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 759362007498 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 759362007499 Substrate binding site; other site 759362007500 Cupin domain; Region: Cupin_2; cl17218 759362007501 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 759362007502 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 759362007503 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 759362007504 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 759362007505 dimer interface [polypeptide binding]; other site 759362007506 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 759362007507 active site 759362007508 Fe binding site [ion binding]; other site 759362007509 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 759362007510 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 759362007511 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 759362007512 shikimate binding site; other site 759362007513 NAD(P) binding site [chemical binding]; other site 759362007514 Transcriptional regulators [Transcription]; Region: GntR; COG1802 759362007515 DNA-binding site [nucleotide binding]; DNA binding site 759362007516 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 759362007517 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 759362007518 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 759362007519 DNA-binding site [nucleotide binding]; DNA binding site 759362007520 FCD domain; Region: FCD; pfam07729 759362007521 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 759362007522 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 759362007523 DctM-like transporters; Region: DctM; pfam06808 759362007524 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 759362007525 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 759362007526 trimer interface [polypeptide binding]; other site 759362007527 active site 759362007528 dimer interface [polypeptide binding]; other site 759362007529 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 759362007530 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 759362007531 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 759362007532 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 759362007533 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 759362007534 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 759362007535 dimerization interface [polypeptide binding]; other site 759362007536 substrate binding pocket [chemical binding]; other site 759362007537 Membrane transport protein; Region: Mem_trans; cl09117 759362007538 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 759362007539 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl19058 759362007540 dimer interface [polypeptide binding]; other site 759362007541 active site 759362007542 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 759362007543 metal ion-dependent adhesion site (MIDAS); other site 759362007544 MoxR-like ATPases [General function prediction only]; Region: COG0714 759362007545 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759362007546 Walker A motif; other site 759362007547 ATP binding site [chemical binding]; other site 759362007548 Walker B motif; other site 759362007549 arginine finger; other site 759362007550 Protein of unknown function DUF58; Region: DUF58; pfam01882 759362007551 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 759362007552 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 759362007553 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 759362007554 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 759362007555 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 759362007556 Uncharacterized conserved protein [Function unknown]; Region: COG3339 759362007557 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 759362007558 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 759362007559 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cd04795 759362007560 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 759362007561 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759362007562 Walker A/P-loop; other site 759362007563 ATP binding site [chemical binding]; other site 759362007564 Q-loop/lid; other site 759362007565 ABC transporter signature motif; other site 759362007566 Walker B; other site 759362007567 D-loop; other site 759362007568 H-loop/switch region; other site 759362007569 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 759362007570 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 759362007571 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 759362007572 substrate binding site; other site 759362007573 tetramer interface; other site 759362007574 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 759362007575 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 759362007576 NADP binding site [chemical binding]; other site 759362007577 active site 759362007578 putative substrate binding site [chemical binding]; other site 759362007579 Hint domain; Region: Hint_2; pfam13403 759362007580 Transcriptional regulator [Transcription]; Region: LysR; COG0583 759362007581 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 759362007582 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 759362007583 dimerization interface [polypeptide binding]; other site 759362007584 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 759362007585 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 759362007586 Creatinine amidohydrolase; Region: Creatininase; pfam02633 759362007587 Creatinine amidohydrolase; Region: Creatininase; pfam02633 759362007588 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 759362007589 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759362007590 Walker A/P-loop; other site 759362007591 ATP binding site [chemical binding]; other site 759362007592 Q-loop/lid; other site 759362007593 ABC transporter signature motif; other site 759362007594 Walker B; other site 759362007595 D-loop; other site 759362007596 H-loop/switch region; other site 759362007597 TOBE domain; Region: TOBE_2; pfam08402 759362007598 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 759362007599 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 759362007600 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362007601 dimer interface [polypeptide binding]; other site 759362007602 conserved gate region; other site 759362007603 putative PBP binding loops; other site 759362007604 ABC-ATPase subunit interface; other site 759362007605 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362007606 dimer interface [polypeptide binding]; other site 759362007607 conserved gate region; other site 759362007608 putative PBP binding loops; other site 759362007609 ABC-ATPase subunit interface; other site 759362007610 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 759362007611 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 759362007612 active site residue [active] 759362007613 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 759362007614 active site residue [active] 759362007615 Sulphur transport; Region: Sulf_transp; cl19477 759362007616 Sulphur transport; Region: Sulf_transp; cl19477 759362007617 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 759362007618 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 759362007619 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 759362007620 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 759362007621 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 759362007622 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 759362007623 catalytic loop [active] 759362007624 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 759362007625 iron binding site [ion binding]; other site 759362007626 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 759362007627 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 759362007628 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 759362007629 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 759362007630 substrate binding pocket [chemical binding]; other site 759362007631 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 759362007632 B12 binding site [chemical binding]; other site 759362007633 cobalt ligand [ion binding]; other site 759362007634 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 759362007635 ATPase MipZ; Region: MipZ; pfam09140 759362007636 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 759362007637 P-loop; other site 759362007638 Magnesium ion binding site [ion binding]; other site 759362007639 helicase 45; Provisional; Region: PTZ00424 759362007640 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 759362007641 ATP binding site [chemical binding]; other site 759362007642 Mg++ binding site [ion binding]; other site 759362007643 motif III; other site 759362007644 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 759362007645 nucleotide binding region [chemical binding]; other site 759362007646 ATP-binding site [chemical binding]; other site 759362007647 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 759362007648 putative deacylase active site [active] 759362007649 Uncharacterized conserved protein [Function unknown]; Region: COG1742 759362007650 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 759362007651 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 759362007652 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 759362007653 RimM N-terminal domain; Region: RimM; pfam01782 759362007654 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13828 759362007655 PRC-barrel domain; Region: PRC; pfam05239 759362007656 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 759362007657 chorismate mutase; Provisional; Region: PRK09239 759362007658 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 759362007659 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 759362007660 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 759362007661 signal recognition particle protein; Provisional; Region: PRK10867 759362007662 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 759362007663 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 759362007664 P loop; other site 759362007665 GTP binding site [chemical binding]; other site 759362007666 Signal peptide binding domain; Region: SRP_SPB; pfam02978 759362007667 Transcriptional regulator [Transcription]; Region: LysR; COG0583 759362007668 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 759362007669 LysR substrate binding domain; Region: LysR_substrate; pfam03466 759362007670 dimerization interface [polypeptide binding]; other site 759362007671 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 759362007672 dimerization interface [polypeptide binding]; other site 759362007673 putative DNA binding site [nucleotide binding]; other site 759362007674 putative Zn2+ binding site [ion binding]; other site 759362007675 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 759362007676 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 759362007677 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 759362007678 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 759362007679 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 759362007680 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 759362007681 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 759362007682 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 759362007683 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 759362007684 DNA-binding site [nucleotide binding]; DNA binding site 759362007685 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 759362007686 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 759362007687 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 759362007688 ligand binding site [chemical binding]; other site 759362007689 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 759362007690 Helix-turn-helix domain; Region: HTH_18; pfam12833 759362007691 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 759362007692 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 759362007693 DNA binding site [nucleotide binding] 759362007694 active site 759362007695 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 759362007696 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 759362007697 minor groove reading motif; other site 759362007698 helix-hairpin-helix signature motif; other site 759362007699 substrate binding pocket [chemical binding]; other site 759362007700 active site 759362007701 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 759362007702 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 759362007703 tetramer interface [polypeptide binding]; other site 759362007704 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759362007705 catalytic residue [active] 759362007706 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 759362007707 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 759362007708 NAD binding site [chemical binding]; other site 759362007709 homotetramer interface [polypeptide binding]; other site 759362007710 homodimer interface [polypeptide binding]; other site 759362007711 substrate binding site [chemical binding]; other site 759362007712 active site 759362007713 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 759362007714 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 759362007715 dimer interface [polypeptide binding]; other site 759362007716 active site 759362007717 3-hydroxydecanoyl-(acyl carrier protein) dehydratase; Validated; Region: PRK05174 759362007718 active site 2 [active] 759362007719 active site 1 [active] 759362007720 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 759362007721 metal binding site 2 [ion binding]; metal-binding site 759362007722 putative DNA binding helix; other site 759362007723 metal binding site 1 [ion binding]; metal-binding site 759362007724 dimer interface [polypeptide binding]; other site 759362007725 structural Zn2+ binding site [ion binding]; other site 759362007726 replicative DNA helicase; Provisional; Region: PRK05973 759362007727 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 759362007728 Chain length determinant protein; Region: Wzz; cl19730 759362007729 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 759362007730 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 759362007731 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759362007732 Walker A/P-loop; other site 759362007733 ATP binding site [chemical binding]; other site 759362007734 Q-loop/lid; other site 759362007735 ABC transporter signature motif; other site 759362007736 Walker B; other site 759362007737 D-loop; other site 759362007738 H-loop/switch region; other site 759362007739 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 759362007740 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 759362007741 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 759362007742 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 759362007743 MAPEG family; Region: MAPEG; cl09190 759362007744 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 759362007745 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 759362007746 E3 interaction surface; other site 759362007747 lipoyl attachment site [posttranslational modification]; other site 759362007748 e3 binding domain; Region: E3_binding; pfam02817 759362007749 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 759362007750 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 759362007751 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 759362007752 TPP-binding site [chemical binding]; other site 759362007753 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 759362007754 dimer interface [polypeptide binding]; other site 759362007755 PYR/PP interface [polypeptide binding]; other site 759362007756 TPP binding site [chemical binding]; other site 759362007757 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 759362007758 CoA binding domain; Region: CoA_binding; pfam02629 759362007759 CoA-ligase; Region: Ligase_CoA; pfam00549 759362007760 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 759362007761 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 759362007762 CoA-ligase; Region: Ligase_CoA; pfam00549 759362007763 malate dehydrogenase; Reviewed; Region: PRK06223 759362007764 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 759362007765 NAD(P) binding site [chemical binding]; other site 759362007766 dimer interface [polypeptide binding]; other site 759362007767 tetramer (dimer of dimers) interface [polypeptide binding]; other site 759362007768 substrate binding site [chemical binding]; other site 759362007769 Domain of unknown function (DUF1737); Region: DUF1737; cl10503 759362007770 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 759362007771 Iron-sulfur protein interface; other site 759362007772 proximal quinone binding site [chemical binding]; other site 759362007773 SdhD (CybS) interface [polypeptide binding]; other site 759362007774 proximal heme binding site [chemical binding]; other site 759362007775 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 759362007776 Iron-sulfur protein interface; other site 759362007777 proximal heme binding site [chemical binding]; other site 759362007778 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 759362007779 L-aspartate oxidase; Provisional; Region: PRK06175 759362007780 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 759362007781 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 759362007782 FMN binding site [chemical binding]; other site 759362007783 dimer interface [polypeptide binding]; other site 759362007784 Domain of unknown function (DUF4329); Region: DUF4329; pfam14220 759362007785 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 759362007786 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 759362007787 DNA-binding site [nucleotide binding]; DNA binding site 759362007788 UTRA domain; Region: UTRA; pfam07702 759362007789 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 759362007790 Coenzyme A binding pocket [chemical binding]; other site 759362007791 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 759362007792 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 759362007793 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 759362007794 substrate binding site [chemical binding]; other site 759362007795 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 759362007796 dimer interface [polypeptide binding]; other site 759362007797 active site 759362007798 metal binding site [ion binding]; metal-binding site 759362007799 glutathione binding site [chemical binding]; other site 759362007800 Predicted esterase [General function prediction only]; Region: COG0627 759362007801 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 759362007802 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 759362007803 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 759362007804 substrate binding site [chemical binding]; other site 759362007805 catalytic Zn binding site [ion binding]; other site 759362007806 NAD binding site [chemical binding]; other site 759362007807 structural Zn binding site [ion binding]; other site 759362007808 dimer interface [polypeptide binding]; other site 759362007809 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 759362007810 putative homodimer interface [polypeptide binding]; other site 759362007811 putative homotetramer interface [polypeptide binding]; other site 759362007812 putative metal binding site [ion binding]; other site 759362007813 putative homodimer-homodimer interface [polypeptide binding]; other site 759362007814 putative allosteric switch controlling residues; other site 759362007815 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 759362007816 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 759362007817 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 759362007818 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 759362007819 2-enoyl thioester reductase (ETR) like proteins, child 2; Region: ETR_like_2; cd08292 759362007820 putative NAD(P) binding site [chemical binding]; other site 759362007821 putative dimer interface [polypeptide binding]; other site 759362007822 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 759362007823 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 759362007824 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 759362007825 Domain of unknown function (DUF336); Region: DUF336; pfam03928 759362007826 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 759362007827 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 759362007828 active site 759362007829 substrate binding site [chemical binding]; other site 759362007830 FMN binding site [chemical binding]; other site 759362007831 putative catalytic residues [active] 759362007832 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362007833 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 759362007834 Walker A/P-loop; other site 759362007835 ATP binding site [chemical binding]; other site 759362007836 Q-loop/lid; other site 759362007837 ABC transporter signature motif; other site 759362007838 Walker B; other site 759362007839 D-loop; other site 759362007840 H-loop/switch region; other site 759362007841 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362007842 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 759362007843 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362007844 Walker A/P-loop; other site 759362007845 ATP binding site [chemical binding]; other site 759362007846 Q-loop/lid; other site 759362007847 ABC transporter signature motif; other site 759362007848 Walker B; other site 759362007849 D-loop; other site 759362007850 H-loop/switch region; other site 759362007851 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362007852 dipeptide transporter; Provisional; Region: PRK10913 759362007853 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 759362007854 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362007855 dimer interface [polypeptide binding]; other site 759362007856 conserved gate region; other site 759362007857 putative PBP binding loops; other site 759362007858 ABC-ATPase subunit interface; other site 759362007859 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 759362007860 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362007861 dimer interface [polypeptide binding]; other site 759362007862 conserved gate region; other site 759362007863 putative PBP binding loops; other site 759362007864 ABC-ATPase subunit interface; other site 759362007865 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 759362007866 homotrimer interaction site [polypeptide binding]; other site 759362007867 putative active site [active] 759362007868 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 759362007869 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 759362007870 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 759362007871 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 759362007872 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 759362007873 peptide binding site [polypeptide binding]; other site 759362007874 Transcriptional regulator [Transcription]; Region: LysR; COG0583 759362007875 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 759362007876 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 759362007877 dimerization interface [polypeptide binding]; other site 759362007878 Transcriptional regulators [Transcription]; Region: GntR; COG1802 759362007879 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 759362007880 DNA-binding site [nucleotide binding]; DNA binding site 759362007881 FCD domain; Region: FCD; pfam07729 759362007882 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 759362007883 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362007884 dimer interface [polypeptide binding]; other site 759362007885 conserved gate region; other site 759362007886 putative PBP binding loops; other site 759362007887 ABC-ATPase subunit interface; other site 759362007888 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 759362007889 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362007890 dimer interface [polypeptide binding]; other site 759362007891 conserved gate region; other site 759362007892 putative PBP binding loops; other site 759362007893 ABC-ATPase subunit interface; other site 759362007894 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 759362007895 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 759362007896 Walker A/P-loop; other site 759362007897 ATP binding site [chemical binding]; other site 759362007898 Q-loop/lid; other site 759362007899 ABC transporter signature motif; other site 759362007900 Walker B; other site 759362007901 D-loop; other site 759362007902 H-loop/switch region; other site 759362007903 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 759362007904 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 759362007905 substrate binding pocket [chemical binding]; other site 759362007906 membrane-bound complex binding site; other site 759362007907 hinge residues; other site 759362007908 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 759362007909 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 759362007910 NAD(P) binding site [chemical binding]; other site 759362007911 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 759362007912 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 759362007913 Coenzyme A binding pocket [chemical binding]; other site 759362007914 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 759362007915 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 759362007916 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 759362007917 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 759362007918 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 759362007919 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 759362007920 FeS/SAM binding site; other site 759362007921 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 759362007922 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759362007923 putative substrate translocation pore; other site 759362007924 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 759362007925 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 759362007926 TPP-binding site; other site 759362007927 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 759362007928 PYR/PP interface [polypeptide binding]; other site 759362007929 dimer interface [polypeptide binding]; other site 759362007930 TPP binding site [chemical binding]; other site 759362007931 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 759362007932 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 759362007933 substrate binding pocket [chemical binding]; other site 759362007934 aspartate-rich region 2; other site 759362007935 substrate-Mg2+ binding site; other site 759362007936 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 759362007937 Uncharacterized conserved protein [Function unknown]; Region: COG2835 759362007938 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 759362007939 PAS domain; Region: PAS_9; pfam13426 759362007940 putative active site [active] 759362007941 heme pocket [chemical binding]; other site 759362007942 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 759362007943 metal binding site [ion binding]; metal-binding site 759362007944 active site 759362007945 I-site; other site 759362007946 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 759362007947 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 759362007948 Cu(I) binding site [ion binding]; other site 759362007949 Outer membrane protein family (DUF1597); Region: DUF1597; cl19301 759362007950 Protein of unknown function (DUF461); Region: DUF461; pfam04314 759362007951 Protein of unknown function (DUF461); Region: DUF461; pfam04314 759362007952 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 759362007953 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 759362007954 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 759362007955 AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052 759362007956 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 759362007957 Cytochrome c; Region: Cytochrom_C; pfam00034 759362007958 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 759362007959 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 759362007960 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 759362007961 Coenzyme A binding pocket [chemical binding]; other site 759362007962 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 759362007963 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 759362007964 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 759362007965 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 759362007966 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 759362007967 aspartate kinase; Reviewed; Region: PRK06635 759362007968 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 759362007969 putative nucleotide binding site [chemical binding]; other site 759362007970 putative catalytic residues [active] 759362007971 putative Mg ion binding site [ion binding]; other site 759362007972 putative aspartate binding site [chemical binding]; other site 759362007973 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 759362007974 putative allosteric regulatory site; other site 759362007975 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 759362007976 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 759362007977 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 759362007978 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 759362007979 Outer membrane efflux protein; Region: OEP; pfam02321 759362007980 Outer membrane efflux protein; Region: OEP; pfam02321 759362007981 Putative lysophospholipase; Region: Hydrolase_4; cl19140 759362007982 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 759362007983 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 759362007984 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 759362007985 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 759362007986 dimerization interface [polypeptide binding]; other site 759362007987 putative active cleft [active] 759362007988 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 759362007989 MMPL family; Region: MMPL; cl14618 759362007990 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 759362007991 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 759362007992 HlyD family secretion protein; Region: HlyD_3; pfam13437 759362007993 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 759362007994 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 759362007995 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759362007996 Walker A/P-loop; other site 759362007997 ATP binding site [chemical binding]; other site 759362007998 Q-loop/lid; other site 759362007999 ABC transporter signature motif; other site 759362008000 Walker B; other site 759362008001 D-loop; other site 759362008002 H-loop/switch region; other site 759362008003 Hint domain; Region: Hint_2; pfam13403 759362008004 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 759362008005 Cytochrome oxidase subunit II; Region: Cyto_ox_2; cl12219 759362008006 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 759362008007 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 759362008008 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 759362008009 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759362008010 Walker A/P-loop; other site 759362008011 ATP binding site [chemical binding]; other site 759362008012 Q-loop/lid; other site 759362008013 ABC transporter signature motif; other site 759362008014 Walker B; other site 759362008015 D-loop; other site 759362008016 H-loop/switch region; other site 759362008017 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 759362008018 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 759362008019 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 759362008020 Walker A/P-loop; other site 759362008021 ATP binding site [chemical binding]; other site 759362008022 Q-loop/lid; other site 759362008023 ABC transporter signature motif; other site 759362008024 Walker B; other site 759362008025 D-loop; other site 759362008026 H-loop/switch region; other site 759362008027 Putative phosphatase (DUF442); Region: DUF442; cl17385 759362008028 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759362008029 putative substrate translocation pore; other site 759362008030 Major Facilitator Superfamily; Region: MFS_1; pfam07690 759362008031 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 759362008032 dimerization interface [polypeptide binding]; other site 759362008033 putative DNA binding site [nucleotide binding]; other site 759362008034 putative Zn2+ binding site [ion binding]; other site 759362008035 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 759362008036 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 759362008037 DNA binding residues [nucleotide binding] 759362008038 dimer interface [polypeptide binding]; other site 759362008039 copper binding site [ion binding]; other site 759362008040 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 759362008041 metal-binding site [ion binding] 759362008042 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 759362008043 Uncharacterized conserved protein [Function unknown]; Region: COG4121 759362008044 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 759362008045 FAD dependent oxidoreductase; Region: DAO; pfam01266 759362008046 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 759362008047 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 759362008048 MPT binding site; other site 759362008049 trimer interface [polypeptide binding]; other site 759362008050 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 759362008051 Fe-S cluster binding site [ion binding]; other site 759362008052 active site 759362008053 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 759362008054 homodimer interface [polypeptide binding]; other site 759362008055 substrate-cofactor binding pocket; other site 759362008056 pyridoxal 5'-phosphate binding site [chemical binding]; other site 759362008057 catalytic residue [active] 759362008058 Protein of unknown function (DUF1244); Region: DUF1244; cl01385 759362008059 N-formylglutamate amidohydrolase; Region: FGase; cl01522 759362008060 pyruvate kinase; Provisional; Region: PRK06247 759362008061 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 759362008062 domain interfaces; other site 759362008063 active site 759362008064 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 759362008065 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 759362008066 23S rRNA binding site [nucleotide binding]; other site 759362008067 L21 binding site [polypeptide binding]; other site 759362008068 L13 binding site [polypeptide binding]; other site 759362008069 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 759362008070 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 759362008071 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 759362008072 dimer interface [polypeptide binding]; other site 759362008073 motif 1; other site 759362008074 active site 759362008075 motif 2; other site 759362008076 motif 3; other site 759362008077 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 759362008078 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 759362008079 putative tRNA-binding site [nucleotide binding]; other site 759362008080 B3/4 domain; Region: B3_4; pfam03483 759362008081 tRNA synthetase B5 domain; Region: B5; smart00874 759362008082 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 759362008083 dimer interface [polypeptide binding]; other site 759362008084 motif 1; other site 759362008085 motif 3; other site 759362008086 motif 2; other site 759362008087 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 759362008088 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 759362008089 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 759362008090 C-terminal domain interface [polypeptide binding]; other site 759362008091 GSH binding site (G-site) [chemical binding]; other site 759362008092 dimer interface [polypeptide binding]; other site 759362008093 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 759362008094 dimer interface [polypeptide binding]; other site 759362008095 N-terminal domain interface [polypeptide binding]; other site 759362008096 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 759362008097 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 759362008098 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 759362008099 putative DNA binding site [nucleotide binding]; other site 759362008100 putative Zn2+ binding site [ion binding]; other site 759362008101 AsnC family; Region: AsnC_trans_reg; pfam01037 759362008102 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 759362008103 1-deoxy-D-xylulose-5-phosphate synthase; Region: PLN02234 759362008104 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 759362008105 dimerization domain swap beta strand [polypeptide binding]; other site 759362008106 regulatory protein interface [polypeptide binding]; other site 759362008107 active site 759362008108 regulatory phosphorylation site [posttranslational modification]; other site 759362008109 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 759362008110 active pocket/dimerization site; other site 759362008111 active site 759362008112 phosphorylation site [posttranslational modification] 759362008113 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 759362008114 AAA domain; Region: AAA_33; pfam13671 759362008115 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cd00133 759362008116 active site 759362008117 P-loop; other site 759362008118 phosphorylation site [posttranslational modification] 759362008119 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 759362008120 Hpr binding site; other site 759362008121 active site 759362008122 homohexamer subunit interaction site [polypeptide binding]; other site 759362008123 phosphoenolpyruvate carboxykinase; Provisional; Region: PRK09344 759362008124 active site 759362008125 metal-binding site [ion binding] 759362008126 nucleotide-binding site [chemical binding]; other site 759362008127 Domain of unknown function (DUF3859); Region: DUF3859; pfam12975 759362008128 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 759362008129 B1 nucleotide binding pocket [chemical binding]; other site 759362008130 B2 nucleotide binding pocket [chemical binding]; other site 759362008131 CAS motifs; other site 759362008132 active site 759362008133 Protein of unknown function (DUF1013); Region: DUF1013; cl11533 759362008134 glucosyltransferase MdoH; Provisional; Region: PRK05454 759362008135 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 759362008136 active site 759362008137 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 759362008138 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 759362008139 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 759362008140 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 759362008141 Coenzyme A binding pocket [chemical binding]; other site 759362008142 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 759362008143 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 759362008144 dimer interface [polypeptide binding]; other site 759362008145 anticodon binding site; other site 759362008146 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 759362008147 motif 1; other site 759362008148 dimer interface [polypeptide binding]; other site 759362008149 active site 759362008150 motif 2; other site 759362008151 GAD domain; Region: GAD; pfam02938 759362008152 motif 3; other site 759362008153 Protein of unknown function (DUF1467); Region: DUF1467; pfam07330 759362008154 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 759362008155 FMN binding site [chemical binding]; other site 759362008156 dimer interface [polypeptide binding]; other site 759362008157 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 759362008158 Peptidase family M48; Region: Peptidase_M48; cl12018 759362008159 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 759362008160 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 759362008161 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 759362008162 FeS/SAM binding site; other site 759362008163 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 759362008164 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 759362008165 PII uridylyl-transferase; Provisional; Region: PRK05092 759362008166 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 759362008167 metal binding triad; other site 759362008168 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 759362008169 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 759362008170 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 759362008171 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 759362008172 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 759362008173 putative SAM binding site [chemical binding]; other site 759362008174 putative homodimer interface [polypeptide binding]; other site 759362008175 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 759362008176 glutathione synthetase; Provisional; Region: PRK05246 759362008177 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 759362008178 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 759362008179 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 759362008180 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 759362008181 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759362008182 Walker A motif; other site 759362008183 ATP binding site [chemical binding]; other site 759362008184 Walker B motif; other site 759362008185 arginine finger; other site 759362008186 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 759362008187 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 759362008188 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 759362008189 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 759362008190 ATP binding site [chemical binding]; other site 759362008191 substrate interface [chemical binding]; other site 759362008192 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 759362008193 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 759362008194 active site 759362008195 Zn binding site [ion binding]; other site 759362008196 Cation efflux family; Region: Cation_efflux; cl00316 759362008197 Bacterial SH3 domain; Region: SH3_4; pfam06347 759362008198 Bacterial SH3 domain; Region: SH3_4; pfam06347 759362008199 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 759362008200 putative ligand binding site [chemical binding]; other site 759362008201 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 759362008202 TM-ABC transporter signature motif; other site 759362008203 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 759362008204 TM-ABC transporter signature motif; other site 759362008205 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 759362008206 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 759362008207 Walker A/P-loop; other site 759362008208 ATP binding site [chemical binding]; other site 759362008209 Q-loop/lid; other site 759362008210 ABC transporter signature motif; other site 759362008211 Walker B; other site 759362008212 D-loop; other site 759362008213 H-loop/switch region; other site 759362008214 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 759362008215 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 759362008216 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 759362008217 XdhC Rossmann domain; Region: XdhC_C; pfam13478 759362008218 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 759362008219 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 759362008220 PLD-like domain; Region: PLDc_2; pfam13091 759362008221 putative active site [active] 759362008222 catalytic site [active] 759362008223 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 759362008224 ParB-like nuclease domain; Region: ParBc; pfam02195 759362008225 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 759362008226 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 759362008227 P-loop; other site 759362008228 Magnesium ion binding site [ion binding]; other site 759362008229 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 759362008230 Magnesium ion binding site [ion binding]; other site 759362008231 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 759362008232 DnaA N-terminal domain; Region: DnaA_N; pfam11638 759362008233 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 759362008234 Transcriptional regulators [Transcription]; Region: PurR; COG1609 759362008235 DNA binding site [nucleotide binding] 759362008236 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 759362008237 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 759362008238 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 759362008239 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 759362008240 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 759362008241 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 759362008242 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 759362008243 Cytochrome c; Region: Cytochrom_C; pfam00034 759362008244 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 759362008245 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 759362008246 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 759362008247 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 759362008248 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 759362008249 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 759362008250 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 759362008251 dimerization interface [polypeptide binding]; other site 759362008252 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 759362008253 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 759362008254 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 759362008255 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362008256 dimer interface [polypeptide binding]; other site 759362008257 conserved gate region; other site 759362008258 putative PBP binding loops; other site 759362008259 ABC-ATPase subunit interface; other site 759362008260 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 759362008261 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362008262 dimer interface [polypeptide binding]; other site 759362008263 conserved gate region; other site 759362008264 putative PBP binding loops; other site 759362008265 ABC-ATPase subunit interface; other site 759362008266 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 759362008267 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362008268 Walker A/P-loop; other site 759362008269 ATP binding site [chemical binding]; other site 759362008270 Q-loop/lid; other site 759362008271 ABC transporter signature motif; other site 759362008272 Walker B; other site 759362008273 D-loop; other site 759362008274 H-loop/switch region; other site 759362008275 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362008276 Walker A/P-loop; other site 759362008277 ATP binding site [chemical binding]; other site 759362008278 Q-loop/lid; other site 759362008279 ABC transporter signature motif; other site 759362008280 Walker B; other site 759362008281 D-loop; other site 759362008282 H-loop/switch region; other site 759362008283 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362008284 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 759362008285 Putative lysophospholipase; Region: Hydrolase_4; cl19140 759362008286 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 759362008287 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362008288 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 759362008289 Walker A/P-loop; other site 759362008290 ATP binding site [chemical binding]; other site 759362008291 Q-loop/lid; other site 759362008292 ABC transporter signature motif; other site 759362008293 Walker B; other site 759362008294 D-loop; other site 759362008295 H-loop/switch region; other site 759362008296 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362008297 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 759362008298 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362008299 Walker A/P-loop; other site 759362008300 ATP binding site [chemical binding]; other site 759362008301 Q-loop/lid; other site 759362008302 ABC transporter signature motif; other site 759362008303 Walker B; other site 759362008304 D-loop; other site 759362008305 H-loop/switch region; other site 759362008306 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362008307 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 759362008308 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362008309 dimer interface [polypeptide binding]; other site 759362008310 conserved gate region; other site 759362008311 putative PBP binding loops; other site 759362008312 ABC-ATPase subunit interface; other site 759362008313 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 759362008314 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362008315 dimer interface [polypeptide binding]; other site 759362008316 conserved gate region; other site 759362008317 putative PBP binding loops; other site 759362008318 ABC-ATPase subunit interface; other site 759362008319 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 759362008320 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 759362008321 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 759362008322 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 759362008323 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 759362008324 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 759362008325 active site 759362008326 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; cl19816 759362008327 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 759362008328 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 759362008329 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 759362008330 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 759362008331 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 759362008332 non-specific DNA binding site [nucleotide binding]; other site 759362008333 salt bridge; other site 759362008334 sequence-specific DNA binding site [nucleotide binding]; other site 759362008335 Cupin domain; Region: Cupin_2; pfam07883 759362008336 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 759362008337 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362008338 Walker A/P-loop; other site 759362008339 ATP binding site [chemical binding]; other site 759362008340 Q-loop/lid; other site 759362008341 ABC transporter signature motif; other site 759362008342 Walker B; other site 759362008343 D-loop; other site 759362008344 H-loop/switch region; other site 759362008345 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362008346 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 759362008347 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362008348 Walker A/P-loop; other site 759362008349 ATP binding site [chemical binding]; other site 759362008350 Q-loop/lid; other site 759362008351 ABC transporter signature motif; other site 759362008352 Walker B; other site 759362008353 D-loop; other site 759362008354 H-loop/switch region; other site 759362008355 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362008356 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 759362008357 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 759362008358 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362008359 dimer interface [polypeptide binding]; other site 759362008360 conserved gate region; other site 759362008361 putative PBP binding loops; other site 759362008362 ABC-ATPase subunit interface; other site 759362008363 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 759362008364 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362008365 dimer interface [polypeptide binding]; other site 759362008366 conserved gate region; other site 759362008367 putative PBP binding loops; other site 759362008368 ABC-ATPase subunit interface; other site 759362008369 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 759362008370 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 759362008371 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 759362008372 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 759362008373 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 759362008374 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; cl19816 759362008375 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 759362008376 Transcriptional regulator [Transcription]; Region: IclR; COG1414 759362008377 Bacterial transcriptional regulator; Region: IclR; pfam01614 759362008378 Protein of unknown function (DUF1007); Region: DUF1007; cl01487 759362008379 High-affinity nickel-transport protein; Region: NicO; cl00964 759362008380 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 759362008381 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 759362008382 metal binding site [ion binding]; metal-binding site 759362008383 putative dimer interface [polypeptide binding]; other site 759362008384 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; cl19816 759362008385 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 759362008386 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 759362008387 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 759362008388 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 759362008389 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 759362008390 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 759362008391 non-specific DNA binding site [nucleotide binding]; other site 759362008392 salt bridge; other site 759362008393 sequence-specific DNA binding site [nucleotide binding]; other site 759362008394 Cupin domain; Region: Cupin_2; pfam07883 759362008395 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 759362008396 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 759362008397 Walker A/P-loop; other site 759362008398 ATP binding site [chemical binding]; other site 759362008399 Q-loop/lid; other site 759362008400 ABC transporter signature motif; other site 759362008401 Walker B; other site 759362008402 D-loop; other site 759362008403 H-loop/switch region; other site 759362008404 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 759362008405 ABC-ATPase subunit interface; other site 759362008406 dimer interface [polypeptide binding]; other site 759362008407 putative PBP binding regions; other site 759362008408 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 759362008409 ABC-ATPase subunit interface; other site 759362008410 dimer interface [polypeptide binding]; other site 759362008411 putative PBP binding regions; other site 759362008412 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 759362008413 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 759362008414 siderophore binding site; other site 759362008415 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 759362008416 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 759362008417 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 759362008418 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 759362008419 dimer interface [polypeptide binding]; other site 759362008420 phosphorylation site [posttranslational modification] 759362008421 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 759362008422 ATP binding site [chemical binding]; other site 759362008423 Mg2+ binding site [ion binding]; other site 759362008424 G-X-G motif; other site 759362008425 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 759362008426 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759362008427 active site 759362008428 phosphorylation site [posttranslational modification] 759362008429 intermolecular recognition site; other site 759362008430 dimerization interface [polypeptide binding]; other site 759362008431 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 759362008432 DNA binding site [nucleotide binding] 759362008433 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759362008434 Walker A/P-loop; other site 759362008435 ATP binding site [chemical binding]; other site 759362008436 N-carbamyl-D-amino acid amidohydrolase (DCase, class 6 nitrilases); Region: DCase; cd07569 759362008437 tetramer interface [polypeptide binding]; other site 759362008438 active site 759362008439 catalytic triad [active] 759362008440 dimer interface [polypeptide binding]; other site 759362008441 dihydropyrimidinase; Provisional; Region: PRK13404 759362008442 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 759362008443 tetramer interface [polypeptide binding]; other site 759362008444 active site 759362008445 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 759362008446 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 759362008447 inhibitor site; inhibition site 759362008448 active site 759362008449 dimer interface [polypeptide binding]; other site 759362008450 catalytic residue [active] 759362008451 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 759362008452 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 759362008453 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 759362008454 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 759362008455 Transcriptional regulators [Transcription]; Region: GntR; COG1802 759362008456 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 759362008457 DNA-binding site [nucleotide binding]; DNA binding site 759362008458 FCD domain; Region: FCD; pfam07729 759362008459 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 759362008460 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 759362008461 active site residue [active] 759362008462 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 759362008463 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 759362008464 active site residue [active] 759362008465 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 759362008466 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 759362008467 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 759362008468 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 759362008469 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 759362008470 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362008471 Walker A/P-loop; other site 759362008472 ATP binding site [chemical binding]; other site 759362008473 Q-loop/lid; other site 759362008474 ABC transporter signature motif; other site 759362008475 Walker B; other site 759362008476 D-loop; other site 759362008477 H-loop/switch region; other site 759362008478 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362008479 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362008480 Walker A/P-loop; other site 759362008481 ATP binding site [chemical binding]; other site 759362008482 Q-loop/lid; other site 759362008483 ABC transporter signature motif; other site 759362008484 Walker B; other site 759362008485 D-loop; other site 759362008486 H-loop/switch region; other site 759362008487 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 759362008488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362008489 dimer interface [polypeptide binding]; other site 759362008490 conserved gate region; other site 759362008491 putative PBP binding loops; other site 759362008492 ABC-ATPase subunit interface; other site 759362008493 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 759362008494 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362008495 dimer interface [polypeptide binding]; other site 759362008496 conserved gate region; other site 759362008497 putative PBP binding loops; other site 759362008498 ABC-ATPase subunit interface; other site 759362008499 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 759362008500 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 759362008501 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 759362008502 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 759362008503 non-specific DNA binding site [nucleotide binding]; other site 759362008504 salt bridge; other site 759362008505 sequence-specific DNA binding site [nucleotide binding]; other site 759362008506 HipA N-terminal domain; Region: Couple_hipA; pfam13657 759362008507 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 759362008508 HipA-like N-terminal domain; Region: HipA_N; pfam07805 759362008509 HipA-like C-terminal domain; Region: HipA_C; pfam07804 759362008510 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759362008511 active site 759362008512 phosphorylation site [posttranslational modification] 759362008513 intermolecular recognition site; other site 759362008514 dimerization interface [polypeptide binding]; other site 759362008515 PAS domain; Region: PAS; smart00091 759362008516 PAS domain; Region: PAS_9; pfam13426 759362008517 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 759362008518 HWE histidine kinase; Region: HWE_HK; pfam07536 759362008519 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 759362008520 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759362008521 active site 759362008522 phosphorylation site [posttranslational modification] 759362008523 intermolecular recognition site; other site 759362008524 dimerization interface [polypeptide binding]; other site 759362008525 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 759362008526 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 759362008527 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 759362008528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362008529 dimer interface [polypeptide binding]; other site 759362008530 conserved gate region; other site 759362008531 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 759362008532 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 759362008533 dimer interface [polypeptide binding]; other site 759362008534 phosphorylation site [posttranslational modification] 759362008535 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 759362008536 ATP binding site [chemical binding]; other site 759362008537 Mg2+ binding site [ion binding]; other site 759362008538 G-X-G motif; other site 759362008539 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759362008540 active site 759362008541 phosphorylation site [posttranslational modification] 759362008542 intermolecular recognition site; other site 759362008543 dimerization interface [polypeptide binding]; other site 759362008544 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759362008545 active site 759362008546 phosphorylation site [posttranslational modification] 759362008547 intermolecular recognition site; other site 759362008548 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 759362008549 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759362008550 active site 759362008551 phosphorylation site [posttranslational modification] 759362008552 intermolecular recognition site; other site 759362008553 dimerization interface [polypeptide binding]; other site 759362008554 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 759362008555 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 759362008556 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 759362008557 active site 759362008558 metal binding site [ion binding]; metal-binding site 759362008559 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759362008560 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 759362008561 Walker A motif; other site 759362008562 ATP binding site [chemical binding]; other site 759362008563 Walker B motif; other site 759362008564 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 759362008565 putative active site [active] 759362008566 putative metal binding site [ion binding]; other site 759362008567 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 759362008568 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 759362008569 Methyltransferase domain; Region: Methyltransf_26; pfam13659 759362008570 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 759362008571 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 759362008572 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447 759362008573 GIY-YIG motif/motif A; other site 759362008574 putative active site [active] 759362008575 putative metal binding site [ion binding]; other site 759362008576 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 759362008577 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 759362008578 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 759362008579 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 759362008580 ATP binding site [chemical binding]; other site 759362008581 putative Mg++ binding site [ion binding]; other site 759362008582 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4694 759362008583 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759362008584 Walker A/P-loop; other site 759362008585 ATP binding site [chemical binding]; other site 759362008586 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759362008587 ABC transporter signature motif; other site 759362008588 Walker B; other site 759362008589 D-loop; other site 759362008590 H-loop/switch region; other site 759362008591 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 759362008592 Integrase core domain; Region: rve; pfam00665 759362008593 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 759362008594 AAA domain; Region: AAA_22; pfam13401 759362008595 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 759362008596 TniQ; Region: TniQ; pfam06527 759362008597 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 759362008598 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 759362008599 substrate binding site [chemical binding]; other site 759362008600 ATP binding site [chemical binding]; other site 759362008601 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 759362008602 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 759362008603 putative ligand binding site [chemical binding]; other site 759362008604 NAD binding site [chemical binding]; other site 759362008605 catalytic site [active] 759362008606 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 759362008607 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 759362008608 Walker A/P-loop; other site 759362008609 ATP binding site [chemical binding]; other site 759362008610 Q-loop/lid; other site 759362008611 ABC transporter signature motif; other site 759362008612 Walker B; other site 759362008613 D-loop; other site 759362008614 H-loop/switch region; other site 759362008615 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 759362008616 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 759362008617 substrate binding pocket [chemical binding]; other site 759362008618 membrane-bound complex binding site; other site 759362008619 hinge residues; other site 759362008620 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 759362008621 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362008622 dimer interface [polypeptide binding]; other site 759362008623 conserved gate region; other site 759362008624 putative PBP binding loops; other site 759362008625 ABC-ATPase subunit interface; other site 759362008626 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 759362008627 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362008628 dimer interface [polypeptide binding]; other site 759362008629 conserved gate region; other site 759362008630 putative PBP binding loops; other site 759362008631 ABC-ATPase subunit interface; other site 759362008632 Transcriptional regulators [Transcription]; Region: PurR; COG1609 759362008633 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 759362008634 DNA binding site [nucleotide binding] 759362008635 domain linker motif; other site 759362008636 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 759362008637 putative dimerization interface [polypeptide binding]; other site 759362008638 putative ligand binding site [chemical binding]; other site 759362008639 Uncharacterized protein family (UPF0160); Region: UPF0160; pfam03690 759362008640 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 759362008641 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 759362008642 H-NS histone family; Region: Histone_HNS; pfam00816 759362008643 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 759362008644 MgtC family; Region: MgtC; pfam02308 759362008645 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 759362008646 RNA polymerase sigma factor; Provisional; Region: PRK12546 759362008647 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 759362008648 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 759362008649 DNA binding residues [nucleotide binding] 759362008650 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 759362008651 two-component response regulator; Provisional; Region: PRK09191 759362008652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759362008653 active site 759362008654 phosphorylation site [posttranslational modification] 759362008655 intermolecular recognition site; other site 759362008656 dimerization interface [polypeptide binding]; other site 759362008657 PRC-barrel domain; Region: PRC; pfam05239 759362008658 PRC-barrel domain; Region: PRC; pfam05239 759362008659 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 759362008660 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 759362008661 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 759362008662 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 759362008663 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 759362008664 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 759362008665 ATP binding site [chemical binding]; other site 759362008666 Mg++ binding site [ion binding]; other site 759362008667 motif III; other site 759362008668 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 759362008669 nucleotide binding region [chemical binding]; other site 759362008670 ATP-binding site [chemical binding]; other site 759362008671 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 759362008672 RNA binding site [nucleotide binding]; other site 759362008673 malic enzyme; Reviewed; Region: PRK12862 759362008674 Malic enzyme, N-terminal domain; Region: malic; pfam00390 759362008675 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 759362008676 putative NAD(P) binding site [chemical binding]; other site 759362008677 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 759362008678 D-aminopeptidase; Reviewed; Region: PRK13128 759362008679 Beta-lactamase; Region: Beta-lactamase; pfam00144 759362008680 Transcriptional regulator [Transcription]; Region: LysR; COG0583 759362008681 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 759362008682 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 759362008683 dimerization interface [polypeptide binding]; other site 759362008684 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 759362008685 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 759362008686 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 759362008687 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 759362008688 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 759362008689 putative metal binding site [ion binding]; other site 759362008690 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 759362008691 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 759362008692 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 759362008693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362008694 dimer interface [polypeptide binding]; other site 759362008695 conserved gate region; other site 759362008696 putative PBP binding loops; other site 759362008697 ABC-ATPase subunit interface; other site 759362008698 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 759362008699 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 759362008700 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362008701 dimer interface [polypeptide binding]; other site 759362008702 conserved gate region; other site 759362008703 putative PBP binding loops; other site 759362008704 ABC-ATPase subunit interface; other site 759362008705 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 759362008706 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362008707 Walker A/P-loop; other site 759362008708 ATP binding site [chemical binding]; other site 759362008709 Q-loop/lid; other site 759362008710 ABC transporter signature motif; other site 759362008711 Walker B; other site 759362008712 D-loop; other site 759362008713 H-loop/switch region; other site 759362008714 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362008715 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 759362008716 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362008717 Walker A/P-loop; other site 759362008718 ATP binding site [chemical binding]; other site 759362008719 Q-loop/lid; other site 759362008720 ABC transporter signature motif; other site 759362008721 Walker B; other site 759362008722 D-loop; other site 759362008723 H-loop/switch region; other site 759362008724 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 759362008725 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 759362008726 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 759362008727 Histidine kinase; Region: HisKA_3; pfam07730 759362008728 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 759362008729 ATP binding site [chemical binding]; other site 759362008730 Mg2+ binding site [ion binding]; other site 759362008731 G-X-G motif; other site 759362008732 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 759362008733 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759362008734 active site 759362008735 phosphorylation site [posttranslational modification] 759362008736 intermolecular recognition site; other site 759362008737 dimerization interface [polypeptide binding]; other site 759362008738 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 759362008739 DNA binding residues [nucleotide binding] 759362008740 dimerization interface [polypeptide binding]; other site 759362008741 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 759362008742 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 759362008743 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362008744 dimer interface [polypeptide binding]; other site 759362008745 conserved gate region; other site 759362008746 putative PBP binding loops; other site 759362008747 ABC-ATPase subunit interface; other site 759362008748 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362008749 dimer interface [polypeptide binding]; other site 759362008750 conserved gate region; other site 759362008751 putative PBP binding loops; other site 759362008752 ABC-ATPase subunit interface; other site 759362008753 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 759362008754 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 759362008755 Walker A/P-loop; other site 759362008756 ATP binding site [chemical binding]; other site 759362008757 Q-loop/lid; other site 759362008758 ABC transporter signature motif; other site 759362008759 Walker B; other site 759362008760 D-loop; other site 759362008761 H-loop/switch region; other site 759362008762 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 759362008763 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 759362008764 FeS/SAM binding site; other site 759362008765 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 759362008766 Domain of unknown function (DUF4130; Region: DUF4130; pfam13566 759362008767 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 759362008768 Fe-S cluster binding site [ion binding]; other site 759362008769 active site 759362008770 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 759362008771 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 759362008772 NAD(P) binding site [chemical binding]; other site 759362008773 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 759362008774 PA/protease or protease-like domain interface [polypeptide binding]; other site 759362008775 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 759362008776 metal binding site [ion binding]; metal-binding site 759362008777 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 759362008778 Transcriptional regulator [Transcription]; Region: IclR; COG1414 759362008779 Bacterial transcriptional regulator; Region: IclR; pfam01614 759362008780 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 759362008781 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 759362008782 metal binding site [ion binding]; metal-binding site 759362008783 putative dimer interface [polypeptide binding]; other site 759362008784 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 759362008785 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 759362008786 metal binding site [ion binding]; metal-binding site 759362008787 dimer interface [polypeptide binding]; other site 759362008788 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 759362008789 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 759362008790 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 759362008791 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; cl19816 759362008792 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 759362008793 PA/protease or protease-like domain interface [polypeptide binding]; other site 759362008794 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 759362008795 metal binding site [ion binding]; metal-binding site 759362008796 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 759362008797 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 759362008798 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 759362008799 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 759362008800 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 759362008801 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362008802 dimer interface [polypeptide binding]; other site 759362008803 conserved gate region; other site 759362008804 putative PBP binding loops; other site 759362008805 ABC-ATPase subunit interface; other site 759362008806 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 759362008807 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362008808 dimer interface [polypeptide binding]; other site 759362008809 conserved gate region; other site 759362008810 putative PBP binding loops; other site 759362008811 ABC-ATPase subunit interface; other site 759362008812 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 759362008813 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362008814 Walker A/P-loop; other site 759362008815 ATP binding site [chemical binding]; other site 759362008816 Q-loop/lid; other site 759362008817 ABC transporter signature motif; other site 759362008818 Walker B; other site 759362008819 D-loop; other site 759362008820 H-loop/switch region; other site 759362008821 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362008822 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 759362008823 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362008824 Walker A/P-loop; other site 759362008825 ATP binding site [chemical binding]; other site 759362008826 Q-loop/lid; other site 759362008827 ABC transporter signature motif; other site 759362008828 Walker B; other site 759362008829 D-loop; other site 759362008830 H-loop/switch region; other site 759362008831 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362008832 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; cl19816 759362008833 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 759362008834 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 759362008835 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 759362008836 hypothetical protein; Provisional; Region: PRK08201 759362008837 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 759362008838 metal binding site [ion binding]; metal-binding site 759362008839 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759362008840 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 759362008841 Walker A/P-loop; other site 759362008842 ATP binding site [chemical binding]; other site 759362008843 Q-loop/lid; other site 759362008844 ABC transporter signature motif; other site 759362008845 Walker B; other site 759362008846 D-loop; other site 759362008847 H-loop/switch region; other site 759362008848 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 759362008849 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362008850 dimer interface [polypeptide binding]; other site 759362008851 conserved gate region; other site 759362008852 putative PBP binding loops; other site 759362008853 ABC-ATPase subunit interface; other site 759362008854 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 759362008855 phosphogluconate dehydratase; Validated; Region: PRK09054 759362008856 Entner-Doudoroff aldolase; Region: eda; TIGR01182 759362008857 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 759362008858 active site 759362008859 intersubunit interface [polypeptide binding]; other site 759362008860 catalytic residue [active] 759362008861 Transcriptional regulators [Transcription]; Region: FadR; COG2186 759362008862 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 759362008863 DNA-binding site [nucleotide binding]; DNA binding site 759362008864 FCD domain; Region: FCD; pfam07729 759362008865 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 759362008866 AAA domain; Region: AAA_33; pfam13671 759362008867 ATP-binding site [chemical binding]; other site 759362008868 Gluconate-6-phosphate binding site [chemical binding]; other site 759362008869 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 759362008870 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 759362008871 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 759362008872 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362008873 dimer interface [polypeptide binding]; other site 759362008874 conserved gate region; other site 759362008875 putative PBP binding loops; other site 759362008876 ABC-ATPase subunit interface; other site 759362008877 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 759362008878 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362008879 dimer interface [polypeptide binding]; other site 759362008880 conserved gate region; other site 759362008881 putative PBP binding loops; other site 759362008882 ABC-ATPase subunit interface; other site 759362008883 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362008884 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 759362008885 Walker A/P-loop; other site 759362008886 ATP binding site [chemical binding]; other site 759362008887 Q-loop/lid; other site 759362008888 ABC transporter signature motif; other site 759362008889 Walker B; other site 759362008890 D-loop; other site 759362008891 H-loop/switch region; other site 759362008892 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362008893 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 759362008894 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362008895 Walker A/P-loop; other site 759362008896 ATP binding site [chemical binding]; other site 759362008897 Q-loop/lid; other site 759362008898 ABC transporter signature motif; other site 759362008899 Walker B; other site 759362008900 D-loop; other site 759362008901 H-loop/switch region; other site 759362008902 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362008903 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 759362008904 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 759362008905 substrate binding pocket [chemical binding]; other site 759362008906 catalytic triad [active] 759362008907 Transcriptional regulators [Transcription]; Region: MarR; COG1846 759362008908 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 759362008909 putative DNA binding site [nucleotide binding]; other site 759362008910 putative Zn2+ binding site [ion binding]; other site 759362008911 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759362008912 putative substrate translocation pore; other site 759362008913 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 759362008914 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 759362008915 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 759362008916 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 759362008917 HlyD family secretion protein; Region: HlyD_3; pfam13437 759362008918 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 759362008919 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 759362008920 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 759362008921 Uncharacterized conserved protein [Function unknown]; Region: COG3535 759362008922 AroM protein; Region: AroM; cl17601 759362008923 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 759362008924 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 759362008925 DNA binding residues [nucleotide binding] 759362008926 dimerization interface [polypeptide binding]; other site 759362008927 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 759362008928 M20 Peptidases, Poly(aspartic acid) hydrolase-like proteins; Region: M20_PAAh_like; cd03896 759362008929 putative metal binding site [ion binding]; other site 759362008930 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; cl19816 759362008931 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 759362008932 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 759362008933 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 759362008934 Uncharacterized conserved protein [Function unknown]; Region: COG2128 759362008935 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 759362008936 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 759362008937 Transcriptional regulator [Transcription]; Region: LysR; COG0583 759362008938 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 759362008939 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 759362008940 dimerization interface [polypeptide binding]; other site 759362008941 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 759362008942 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 759362008943 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 759362008944 Putative lysophospholipase; Region: Hydrolase_4; cl19140 759362008945 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 759362008946 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 759362008947 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 759362008948 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362008949 dimer interface [polypeptide binding]; other site 759362008950 conserved gate region; other site 759362008951 putative PBP binding loops; other site 759362008952 ABC-ATPase subunit interface; other site 759362008953 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 759362008954 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 759362008955 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362008956 dimer interface [polypeptide binding]; other site 759362008957 conserved gate region; other site 759362008958 putative PBP binding loops; other site 759362008959 ABC-ATPase subunit interface; other site 759362008960 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 759362008961 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362008962 Walker A/P-loop; other site 759362008963 ATP binding site [chemical binding]; other site 759362008964 Q-loop/lid; other site 759362008965 ABC transporter signature motif; other site 759362008966 Walker B; other site 759362008967 D-loop; other site 759362008968 H-loop/switch region; other site 759362008969 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362008970 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 759362008971 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362008972 Walker A/P-loop; other site 759362008973 ATP binding site [chemical binding]; other site 759362008974 Q-loop/lid; other site 759362008975 ABC transporter signature motif; other site 759362008976 Walker B; other site 759362008977 D-loop; other site 759362008978 H-loop/switch region; other site 759362008979 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362008980 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 759362008981 active site 759362008982 dimerization interface [polypeptide binding]; other site 759362008983 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 759362008984 active site 759362008985 catalytic site [active] 759362008986 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 759362008987 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 759362008988 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759362008989 Walker A/P-loop; other site 759362008990 ATP binding site [chemical binding]; other site 759362008991 Q-loop/lid; other site 759362008992 ABC transporter signature motif; other site 759362008993 Walker B; other site 759362008994 D-loop; other site 759362008995 H-loop/switch region; other site 759362008996 TOBE domain; Region: TOBE_2; pfam08402 759362008997 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362008998 dimer interface [polypeptide binding]; other site 759362008999 conserved gate region; other site 759362009000 putative PBP binding loops; other site 759362009001 ABC-ATPase subunit interface; other site 759362009002 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 759362009003 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362009004 dimer interface [polypeptide binding]; other site 759362009005 conserved gate region; other site 759362009006 putative PBP binding loops; other site 759362009007 ABC-ATPase subunit interface; other site 759362009008 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 759362009009 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 759362009010 Transcriptional regulators [Transcription]; Region: PurR; COG1609 759362009011 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 759362009012 DNA binding site [nucleotide binding] 759362009013 domain linker motif; other site 759362009014 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 759362009015 Trehalose utilisation; Region: ThuA; pfam06283 759362009016 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 759362009017 membrane-bound complex binding site; other site 759362009018 hinge residues; other site 759362009019 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 759362009020 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 759362009021 Trp docking motif [polypeptide binding]; other site 759362009022 active site 759362009023 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 759362009024 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 759362009025 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 759362009026 TM-ABC transporter signature motif; other site 759362009027 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 759362009028 TM-ABC transporter signature motif; other site 759362009029 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 759362009030 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 759362009031 Walker A/P-loop; other site 759362009032 ATP binding site [chemical binding]; other site 759362009033 Q-loop/lid; other site 759362009034 ABC transporter signature motif; other site 759362009035 Walker B; other site 759362009036 D-loop; other site 759362009037 H-loop/switch region; other site 759362009038 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 759362009039 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 759362009040 Walker A/P-loop; other site 759362009041 ATP binding site [chemical binding]; other site 759362009042 Q-loop/lid; other site 759362009043 ABC transporter signature motif; other site 759362009044 Walker B; other site 759362009045 D-loop; other site 759362009046 H-loop/switch region; other site 759362009047 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 759362009048 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 759362009049 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 759362009050 Cupin domain; Region: Cupin_2; cl17218 759362009051 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 759362009052 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 759362009053 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 759362009054 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 759362009055 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 759362009056 dimerization interface [polypeptide binding]; other site 759362009057 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 759362009058 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 759362009059 tetramer interface [polypeptide binding]; other site 759362009060 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 759362009061 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 759362009062 heterodimer interface [polypeptide binding]; other site 759362009063 active site 759362009064 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 759362009065 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 759362009066 active site 759362009067 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 759362009068 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 759362009069 Putative lysophospholipase; Region: Hydrolase_4; cl19140 759362009070 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 759362009071 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 759362009072 Bacterial transcriptional regulator; Region: IclR; pfam01614 759362009073 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 759362009074 nucleotide binding site [chemical binding]; other site 759362009075 putative NEF/HSP70 interaction site [polypeptide binding]; other site 759362009076 SBD interface [polypeptide binding]; other site 759362009077 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 759362009078 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 759362009079 NADP binding site [chemical binding]; other site 759362009080 dimer interface [polypeptide binding]; other site 759362009081 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 759362009082 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 759362009083 NAD(P) binding site [chemical binding]; other site 759362009084 active site 759362009085 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 759362009086 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 759362009087 Transcriptional regulators [Transcription]; Region: MarR; COG1846 759362009088 MarR family; Region: MarR_2; pfam12802 759362009089 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759362009090 Major Facilitator Superfamily; Region: MFS_1; pfam07690 759362009091 putative substrate translocation pore; other site 759362009092 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 759362009093 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 759362009094 catalytic residues [active] 759362009095 catalytic nucleophile [active] 759362009096 Recombinase; Region: Recombinase; pfam07508 759362009097 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 759362009098 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 759362009099 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 759362009100 substrate binding pocket [chemical binding]; other site 759362009101 active site 759362009102 iron coordination sites [ion binding]; other site 759362009103 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 759362009104 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 759362009105 AAA domain; Region: AAA_23; pfam13476 759362009106 Walker A/P-loop; other site 759362009107 ATP binding site [chemical binding]; other site 759362009108 AAA domain; Region: AAA_21; pfam13304 759362009109 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 759362009110 putative active site [active] 759362009111 putative metal-binding site [ion binding]; other site 759362009112 McrBC 5-methylcytosine restriction system component; Region: McrBC; pfam10117 759362009113 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 759362009114 Walker A motif; other site 759362009115 ATP binding site [chemical binding]; other site 759362009116 Walker B motif; other site 759362009117 arginine finger; other site 759362009118 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 759362009119 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 759362009120 Protein of unknown function (DUF2958); Region: DUF2958; pfam11171 759362009121 ParB-like nuclease domain; Region: ParBc; pfam02195 759362009122 Calmodulin-binding; Region: Enkurin; pfam13864 759362009123 Methyltransferase domain; Region: Methyltransf_26; pfam13659 759362009124 P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872 759362009125 DEAD-like helicases superfamily; Region: DEXDc; smart00487 759362009126 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 759362009127 ATP binding site [chemical binding]; other site 759362009128 putative Mg++ binding site [ion binding]; other site 759362009129 Helicase_C-like; Region: Helicase_C_4; pfam13871 759362009130 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 759362009131 active site 759362009132 metal binding site [ion binding]; metal-binding site 759362009133 interdomain interaction site; other site 759362009134 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 759362009135 carotene beta-ring hydroxylase; Region: PLN02738 759362009136 Uncharacterized conserved protein [Function unknown]; Region: COG5489 759362009137 Uncharacterized conserved protein (DUF2285); Region: DUF2285; pfam10074 759362009138 Helix-turn-helix domain; Region: HTH_17; pfam12728 759362009139 Replication initiator protein A; Region: RPA; pfam10134 759362009140 ParA-like protein; Provisional; Region: PHA02518 759362009141 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 759362009142 P-loop; other site 759362009143 Magnesium ion binding site [ion binding]; other site 759362009144 Protein of unknown function (DUF2840); Region: DUF2840; pfam11000 759362009145 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 759362009146 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 759362009147 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 759362009148 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 759362009149 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 759362009150 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 759362009151 Protein of unknown function (DUF736); Region: DUF736; pfam05284 759362009152 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 759362009153 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 759362009154 N-acetyl-D-glucosamine binding site [chemical binding]; other site 759362009155 catalytic residue [active] 759362009156 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 759362009157 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 759362009158 Transcriptional regulator [Transcription]; Region: LysR; COG0583 759362009159 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 759362009160 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 759362009161 putative effector binding pocket; other site 759362009162 putative dimerization interface [polypeptide binding]; other site 759362009163 short chain dehydrogenase; Provisional; Region: PRK06172 759362009164 classical (c) SDRs; Region: SDR_c; cd05233 759362009165 NAD(P) binding site [chemical binding]; other site 759362009166 active site 759362009167 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 759362009168 Major royal jelly protein; Region: MRJP; pfam03022 759362009169 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 759362009170 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 759362009171 active site 759362009172 catalytic tetrad [active] 759362009173 Transcriptional regulator [Transcription]; Region: LysR; COG0583 759362009174 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 759362009175 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 759362009176 dimerization interface [polypeptide binding]; other site 759362009177 substrate binding pocket [chemical binding]; other site 759362009178 conjugal transfer coupling protein TraG; Provisional; Region: PRK13876 759362009179 The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126 759362009180 Walker A motif; other site 759362009181 ATP binding site [chemical binding]; other site 759362009182 Walker B motif; other site 759362009183 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 759362009184 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 759362009185 Walker A motif; other site 759362009186 ATP binding site [chemical binding]; other site 759362009187 Walker B motif; other site 759362009188 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 759362009189 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 759362009190 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 759362009191 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759362009192 Walker A/P-loop; other site 759362009193 ATP binding site [chemical binding]; other site 759362009194 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 759362009195 conjugal transfer protein TrbJ; Provisional; Region: PRK13874 759362009196 conjugative transfer region protein TrbK; Region: other_trbK; TIGR04360 759362009197 conjugal transfer protein TrbL; Provisional; Region: PRK13875 759362009198 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 759362009199 conjugal transfer protein TrbF; Provisional; Region: PRK13872 759362009200 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 759362009201 VirB7 interaction site; other site 759362009202 Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948 759362009203 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 759362009204 Protein of unknown function (DUF2274); Region: DUF2274; pfam10038 759362009205 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 759362009206 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 759362009207 HsdM N-terminal domain; Region: HsdM_N; pfam12161 759362009208 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 759362009209 S-adenosylmethionine binding site [chemical binding]; other site 759362009210 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 759362009211 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 759362009212 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 759362009213 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759362009214 Walker A/P-loop; other site 759362009215 ATP binding site [chemical binding]; other site 759362009216 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 759362009217 ABC transporter signature motif; other site 759362009218 Walker B; other site 759362009219 AAA domain; Region: AAA_21; pfam13304 759362009220 D-loop; other site 759362009221 H-loop/switch region; other site 759362009222 TIGR02646 family protein; Region: TIGR02646 759362009223 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 759362009224 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 759362009225 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 759362009226 ATP binding site [chemical binding]; other site 759362009227 putative Mg++ binding site [ion binding]; other site 759362009228 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 759362009229 Putative glucoamylase; Region: Glycoamylase; pfam10091 759362009230 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 759362009231 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 759362009232 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 759362009233 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 759362009234 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 759362009235 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 759362009236 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 759362009237 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362009238 dimer interface [polypeptide binding]; other site 759362009239 conserved gate region; other site 759362009240 putative PBP binding loops; other site 759362009241 ABC-ATPase subunit interface; other site 759362009242 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 759362009243 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362009244 dimer interface [polypeptide binding]; other site 759362009245 conserved gate region; other site 759362009246 putative PBP binding loops; other site 759362009247 ABC-ATPase subunit interface; other site 759362009248 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 759362009249 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362009250 Walker A/P-loop; other site 759362009251 ATP binding site [chemical binding]; other site 759362009252 Q-loop/lid; other site 759362009253 ABC transporter signature motif; other site 759362009254 Walker B; other site 759362009255 D-loop; other site 759362009256 H-loop/switch region; other site 759362009257 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362009258 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 759362009259 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362009260 Walker A/P-loop; other site 759362009261 ATP binding site [chemical binding]; other site 759362009262 Q-loop/lid; other site 759362009263 ABC transporter signature motif; other site 759362009264 Walker B; other site 759362009265 D-loop; other site 759362009266 H-loop/switch region; other site 759362009267 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362009268 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 759362009269 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; cl19223 759362009270 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 759362009271 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 759362009272 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362009273 Walker A/P-loop; other site 759362009274 ATP binding site [chemical binding]; other site 759362009275 Q-loop/lid; other site 759362009276 ABC transporter signature motif; other site 759362009277 Walker B; other site 759362009278 D-loop; other site 759362009279 H-loop/switch region; other site 759362009280 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362009281 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362009282 Walker A/P-loop; other site 759362009283 ATP binding site [chemical binding]; other site 759362009284 Q-loop/lid; other site 759362009285 ABC transporter signature motif; other site 759362009286 Walker B; other site 759362009287 D-loop; other site 759362009288 H-loop/switch region; other site 759362009289 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362009290 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 759362009291 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 759362009292 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 759362009293 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362009294 dimer interface [polypeptide binding]; other site 759362009295 conserved gate region; other site 759362009296 putative PBP binding loops; other site 759362009297 ABC-ATPase subunit interface; other site 759362009298 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 759362009299 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362009300 dimer interface [polypeptide binding]; other site 759362009301 conserved gate region; other site 759362009302 putative PBP binding loops; other site 759362009303 ABC-ATPase subunit interface; other site 759362009304 Transcriptional regulator [Transcription]; Region: LysR; COG0583 759362009305 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 759362009306 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 759362009307 dimerization interface [polypeptide binding]; other site 759362009308 substrate binding pocket [chemical binding]; other site 759362009309 Protein of unknwon function (DUF3008); Region: DUF3008; pfam11450 759362009310 PRC-barrel domain; Region: PRC; pfam05239 759362009311 PRC-barrel domain; Region: PRC; pfam05239 759362009312 PRC-barrel domain; Region: PRC; pfam05239 759362009313 TspO/MBR family; Region: TspO_MBR; pfam03073 759362009314 hypothetical protein; Provisional; Region: PRK13559 759362009315 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 759362009316 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 759362009317 putative active site [active] 759362009318 heme pocket [chemical binding]; other site 759362009319 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 759362009320 putative active site [active] 759362009321 heme pocket [chemical binding]; other site 759362009322 HWE histidine kinase; Region: HWE_HK; smart00911 759362009323 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 759362009324 dimerization interface [polypeptide binding]; other site 759362009325 metal binding site [ion binding]; metal-binding site 759362009326 FAD dependent oxidoreductase; Region: DAO; pfam01266 759362009327 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 759362009328 CheB methylesterase; Region: CheB_methylest; pfam01339 759362009329 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 759362009330 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 759362009331 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 759362009332 PAS domain; Region: PAS_10; pfam13596 759362009333 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 759362009334 HWE histidine kinase; Region: HWE_HK; smart00911 759362009335 RNA polymerase sigma factor; Provisional; Region: PRK12547 759362009336 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 759362009337 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 759362009338 DNA binding residues [nucleotide binding] 759362009339 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 759362009340 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 759362009341 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl19078 759362009342 active site 759362009343 phosphorylation site [posttranslational modification] 759362009344 intermolecular recognition site; other site 759362009345 PRC-barrel domain; Region: PRC; pfam05239 759362009346 oxidoreductase; Provisional; Region: PRK06128 759362009347 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 759362009348 NAD(P) binding site [chemical binding]; other site 759362009349 active site 759362009350 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 759362009351 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 759362009352 heme binding pocket [chemical binding]; other site 759362009353 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 759362009354 domain interactions; other site 759362009355 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 759362009356 active site 759362009357 DNA binding site [nucleotide binding] 759362009358 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 759362009359 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362009360 dimer interface [polypeptide binding]; other site 759362009361 conserved gate region; other site 759362009362 putative PBP binding loops; other site 759362009363 ABC-ATPase subunit interface; other site 759362009364 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 759362009365 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759362009366 Walker A/P-loop; other site 759362009367 ATP binding site [chemical binding]; other site 759362009368 Q-loop/lid; other site 759362009369 ABC transporter signature motif; other site 759362009370 Walker B; other site 759362009371 D-loop; other site 759362009372 H-loop/switch region; other site 759362009373 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 759362009374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362009375 dimer interface [polypeptide binding]; other site 759362009376 conserved gate region; other site 759362009377 putative PBP binding loops; other site 759362009378 ABC-ATPase subunit interface; other site 759362009379 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_3; cd06151 759362009380 homotrimer interaction site [polypeptide binding]; other site 759362009381 putative active site [active] 759362009382 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 759362009383 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 759362009384 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 759362009385 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 759362009386 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 759362009387 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 759362009388 active site 759362009389 non-prolyl cis peptide bond; other site 759362009390 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 759362009391 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 759362009392 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 759362009393 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362009394 dimer interface [polypeptide binding]; other site 759362009395 conserved gate region; other site 759362009396 putative PBP binding loops; other site 759362009397 ABC-ATPase subunit interface; other site 759362009398 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 759362009399 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362009400 dimer interface [polypeptide binding]; other site 759362009401 conserved gate region; other site 759362009402 putative PBP binding loops; other site 759362009403 ABC-ATPase subunit interface; other site 759362009404 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 759362009405 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362009406 Walker A/P-loop; other site 759362009407 ATP binding site [chemical binding]; other site 759362009408 Q-loop/lid; other site 759362009409 ABC transporter signature motif; other site 759362009410 Walker B; other site 759362009411 D-loop; other site 759362009412 H-loop/switch region; other site 759362009413 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362009414 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362009415 Walker A/P-loop; other site 759362009416 ATP binding site [chemical binding]; other site 759362009417 Q-loop/lid; other site 759362009418 ABC transporter signature motif; other site 759362009419 Walker B; other site 759362009420 D-loop; other site 759362009421 H-loop/switch region; other site 759362009422 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 759362009423 Transcriptional regulator [Transcription]; Region: LysR; COG0583 759362009424 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 759362009425 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 759362009426 dimerization interface [polypeptide binding]; other site 759362009427 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 759362009428 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 759362009429 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 759362009430 Transcriptional regulator [Transcription]; Region: IclR; COG1414 759362009431 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 759362009432 Bacterial transcriptional regulator; Region: IclR; pfam01614 759362009433 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 759362009434 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 759362009435 ligand binding site [chemical binding]; other site 759362009436 NAD binding site [chemical binding]; other site 759362009437 dimerization interface [polypeptide binding]; other site 759362009438 catalytic site [active] 759362009439 hypothetical protein; Validated; Region: PRK06201 759362009440 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 759362009441 active site 759362009442 FMN binding site [chemical binding]; other site 759362009443 substrate binding site [chemical binding]; other site 759362009444 homotetramer interface [polypeptide binding]; other site 759362009445 catalytic residue [active] 759362009446 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 759362009447 NMT1/THI5 like; Region: NMT1; pfam09084 759362009448 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 759362009449 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 759362009450 Walker A/P-loop; other site 759362009451 ATP binding site [chemical binding]; other site 759362009452 Q-loop/lid; other site 759362009453 ABC transporter signature motif; other site 759362009454 Walker B; other site 759362009455 D-loop; other site 759362009456 H-loop/switch region; other site 759362009457 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 759362009458 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362009459 dimer interface [polypeptide binding]; other site 759362009460 conserved gate region; other site 759362009461 putative PBP binding loops; other site 759362009462 ABC-ATPase subunit interface; other site 759362009463 YKOF-related Family; Region: Ykof; pfam07615 759362009464 YKOF-related Family; Region: Ykof; pfam07615 759362009465 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 759362009466 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 759362009467 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 759362009468 PAS domain; Region: PAS_8; pfam13188 759362009469 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 759362009470 HWE histidine kinase; Region: HWE_HK; pfam07536 759362009471 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 759362009472 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 759362009473 AIR carboxylase; Region: AIRC; cl00310 759362009474 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 759362009475 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 759362009476 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 759362009477 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 759362009478 Walker A/P-loop; other site 759362009479 ATP binding site [chemical binding]; other site 759362009480 Q-loop/lid; other site 759362009481 ABC transporter signature motif; other site 759362009482 Walker B; other site 759362009483 D-loop; other site 759362009484 H-loop/switch region; other site 759362009485 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 759362009486 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362009487 dimer interface [polypeptide binding]; other site 759362009488 conserved gate region; other site 759362009489 ABC-ATPase subunit interface; other site 759362009490 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 759362009491 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362009492 dimer interface [polypeptide binding]; other site 759362009493 conserved gate region; other site 759362009494 putative PBP binding loops; other site 759362009495 ABC-ATPase subunit interface; other site 759362009496 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 759362009497 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 759362009498 ABC-ATPase subunit interface; other site 759362009499 dimer interface [polypeptide binding]; other site 759362009500 putative PBP binding regions; other site 759362009501 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 759362009502 ABC-ATPase subunit interface; other site 759362009503 dimer interface [polypeptide binding]; other site 759362009504 putative PBP binding regions; other site 759362009505 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 759362009506 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 759362009507 Walker A/P-loop; other site 759362009508 ATP binding site [chemical binding]; other site 759362009509 Q-loop/lid; other site 759362009510 ABC transporter signature motif; other site 759362009511 Walker B; other site 759362009512 D-loop; other site 759362009513 H-loop/switch region; other site 759362009514 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 759362009515 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 759362009516 siderophore binding site; other site 759362009517 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 759362009518 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 759362009519 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 759362009520 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 759362009521 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; cl19859 759362009522 Fic/DOC family; Region: Fic; pfam02661 759362009523 Fic family protein [Function unknown]; Region: COG3177 759362009524 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 759362009525 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 759362009526 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 759362009527 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362009528 dimer interface [polypeptide binding]; other site 759362009529 conserved gate region; other site 759362009530 putative PBP binding loops; other site 759362009531 ABC-ATPase subunit interface; other site 759362009532 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 759362009533 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 759362009534 DNA-binding site [nucleotide binding]; DNA binding site 759362009535 FCD domain; Region: FCD; pfam07729 759362009536 BCCT family transporter; Region: BCCT; pfam02028 759362009537 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 759362009538 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 759362009539 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362009540 Walker A/P-loop; other site 759362009541 ATP binding site [chemical binding]; other site 759362009542 Q-loop/lid; other site 759362009543 ABC transporter signature motif; other site 759362009544 Walker B; other site 759362009545 D-loop; other site 759362009546 H-loop/switch region; other site 759362009547 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362009548 Walker A/P-loop; other site 759362009549 ATP binding site [chemical binding]; other site 759362009550 Q-loop/lid; other site 759362009551 ABC transporter signature motif; other site 759362009552 Walker B; other site 759362009553 D-loop; other site 759362009554 H-loop/switch region; other site 759362009555 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362009556 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 759362009557 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 759362009558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362009559 dimer interface [polypeptide binding]; other site 759362009560 conserved gate region; other site 759362009561 putative PBP binding loops; other site 759362009562 ABC-ATPase subunit interface; other site 759362009563 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 759362009564 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362009565 dimer interface [polypeptide binding]; other site 759362009566 conserved gate region; other site 759362009567 putative PBP binding loops; other site 759362009568 ABC-ATPase subunit interface; other site 759362009569 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 759362009570 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 759362009571 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 759362009572 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 759362009573 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 759362009574 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; cl19816 759362009575 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 759362009576 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 759362009577 Secretory pathway protein Sec39; Region: Sec39; pfam08314 759362009578 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 759362009579 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 759362009580 active site 759362009581 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 759362009582 Dienelactone hydrolase family; Region: DLH; pfam01738 759362009583 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 759362009584 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 759362009585 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 759362009586 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 759362009587 homodimer interface [polypeptide binding]; other site 759362009588 substrate-cofactor binding pocket; other site 759362009589 catalytic residue [active] 759362009590 putative S-transferase; Provisional; Region: PRK11752 759362009591 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 759362009592 C-terminal domain interface [polypeptide binding]; other site 759362009593 GSH binding site (G-site) [chemical binding]; other site 759362009594 dimer interface [polypeptide binding]; other site 759362009595 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 759362009596 dimer interface [polypeptide binding]; other site 759362009597 N-terminal domain interface [polypeptide binding]; other site 759362009598 active site 759362009599 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 759362009600 HEAT repeats; Region: HEAT_2; pfam13646 759362009601 Cytochrome c; Region: Cytochrom_C; pfam00034 759362009602 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 759362009603 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 759362009604 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 759362009605 Transcriptional regulators [Transcription]; Region: FadR; COG2186 759362009606 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 759362009607 DNA-binding site [nucleotide binding]; DNA binding site 759362009608 FCD domain; Region: FCD; pfam07729 759362009609 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 759362009610 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 759362009611 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 759362009612 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 759362009613 active site 759362009614 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 759362009615 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 759362009616 potential frameshift: common BLAST hit: gi|92116567|ref|YP_576296.1| UbiA prenyltransferase 759362009617 UbiA family of prenyltransferases (PTases); Region: PT_UbiA; cl00337 759362009618 UbiA family of prenyltransferases (PTases); Region: PT_UbiA; cl00337 759362009619 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 759362009620 3-dehydroquinate synthase; Reviewed; Region: aroB; PRK06203 759362009621 active site 759362009622 NAD binding site [chemical binding]; other site 759362009623 metal binding site [ion binding]; metal-binding site 759362009624 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 759362009625 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 759362009626 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 759362009627 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 759362009628 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 759362009629 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 759362009630 mannonate dehydratase; Provisional; Region: PRK03906 759362009631 D-mannonate dehydratase [Carbohydrate transport and metabolism]; Region: UxuA; COG1312 759362009632 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 759362009633 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 759362009634 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 759362009635 glucuronate isomerase; Reviewed; Region: PRK02925 759362009636 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 759362009637 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 759362009638 ATP binding site [chemical binding]; other site 759362009639 Mg2+ binding site [ion binding]; other site 759362009640 G-X-G motif; other site 759362009641 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 759362009642 active site 759362009643 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 759362009644 phosphorylation site [posttranslational modification] 759362009645 intermolecular recognition site; other site 759362009646 dimerization interface [polypeptide binding]; other site 759362009647 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 759362009648 DNA binding site [nucleotide binding] 759362009649 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 759362009650 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 759362009651 Initiator Replication protein; Region: Rep_3; pfam01051 759362009652 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 759362009653 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 759362009654 P-loop; other site 759362009655 Magnesium ion binding site [ion binding]; other site 759362009656 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 759362009657 Transcriptional regulators [Transcription]; Region: PurR; COG1609 759362009658 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 759362009659 DNA binding site [nucleotide binding] 759362009660 domain linker motif; other site 759362009661 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 759362009662 dimerization interface [polypeptide binding]; other site 759362009663 ligand binding site [chemical binding]; other site 759362009664 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 759362009665 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 759362009666 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 759362009667 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 759362009668 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362009669 dimer interface [polypeptide binding]; other site 759362009670 conserved gate region; other site 759362009671 putative PBP binding loops; other site 759362009672 ABC-ATPase subunit interface; other site 759362009673 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 759362009674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362009675 dimer interface [polypeptide binding]; other site 759362009676 conserved gate region; other site 759362009677 putative PBP binding loops; other site 759362009678 ABC-ATPase subunit interface; other site 759362009679 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 759362009680 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 759362009681 Walker A/P-loop; other site 759362009682 ATP binding site [chemical binding]; other site 759362009683 Q-loop/lid; other site 759362009684 ABC transporter signature motif; other site 759362009685 Walker B; other site 759362009686 D-loop; other site 759362009687 H-loop/switch region; other site 759362009688 TOBE domain; Region: TOBE_2; pfam08402 759362009689 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 759362009690 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 759362009691 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 759362009692 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 759362009693 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 759362009694 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 759362009695 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 759362009696 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 759362009697 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 759362009698 NAD(P) binding site [chemical binding]; other site 759362009699 active site 759362009700 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 759362009701 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 759362009702 dimer interface [polypeptide binding]; other site 759362009703 active site 759362009704 CoA binding pocket [chemical binding]; other site 759362009705 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 759362009706 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 759362009707 WHG domain; Region: WHG; pfam13305 759362009708 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 759362009709 ParB-like nuclease domain; Region: ParB; smart00470 759362009710 RepB plasmid partitioning protein; Region: RepB; pfam07506 759362009711 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 759362009712 MerR family regulatory protein; Region: MerR; pfam00376 759362009713 DNA binding residues [nucleotide binding] 759362009714 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 759362009715 P-loop; other site 759362009716 Magnesium ion binding site [ion binding]; other site 759362009717 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 759362009718 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 759362009719 FAD binding pocket [chemical binding]; other site 759362009720 FAD binding motif [chemical binding]; other site 759362009721 phosphate binding motif [ion binding]; other site 759362009722 NAD binding pocket [chemical binding]; other site 759362009723 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 759362009724 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 759362009725 Walker A/P-loop; other site 759362009726 ATP binding site [chemical binding]; other site 759362009727 Q-loop/lid; other site 759362009728 ABC transporter signature motif; other site 759362009729 Walker B; other site 759362009730 D-loop; other site 759362009731 H-loop/switch region; other site 759362009732 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 759362009733 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 759362009734 ABC-ATPase subunit interface; other site 759362009735 dimer interface [polypeptide binding]; other site 759362009736 putative PBP binding regions; other site 759362009737 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 759362009738 ABC-ATPase subunit interface; other site 759362009739 dimer interface [polypeptide binding]; other site 759362009740 putative PBP binding regions; other site 759362009741 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 759362009742 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 759362009743 siderophore binding site; other site 759362009744 ferrichrome receptor precursor protein; Provisional; Region: PRK14050 759362009745 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 759362009746 N-terminal plug; other site 759362009747 ligand-binding site [chemical binding]; other site 759362009748 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 759362009749 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 759362009750 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 759362009751 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 759362009752 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 759362009753 Flavodoxin; Region: Flavodoxin_1; pfam00258 759362009754 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 759362009755 FAD binding pocket [chemical binding]; other site 759362009756 FAD binding motif [chemical binding]; other site 759362009757 catalytic residues [active] 759362009758 NAD binding pocket [chemical binding]; other site 759362009759 phosphate binding motif [ion binding]; other site 759362009760 beta-alpha-beta structure motif; other site 759362009761 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 759362009762 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 759362009763 active site 759362009764 dimer interface [polypeptide binding]; other site 759362009765 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 759362009766 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 759362009767 active site 759362009768 FMN binding site [chemical binding]; other site 759362009769 substrate binding site [chemical binding]; other site 759362009770 3Fe-4S cluster binding site [ion binding]; other site 759362009771 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 759362009772 domain_subunit interface; other site 759362009773 Pirin-related protein [General function prediction only]; Region: COG1741 759362009774 Pirin; Region: Pirin; pfam02678 759362009775 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 759362009776 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 759362009777 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 759362009778 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 759362009779 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 759362009780 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 759362009781 Trp docking motif [polypeptide binding]; other site 759362009782 active site 759362009783 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 759362009784 Predicted membrane protein [Function unknown]; Region: COG2860 759362009785 UPF0126 domain; Region: UPF0126; pfam03458 759362009786 UPF0126 domain; Region: UPF0126; pfam03458 759362009787 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 759362009788 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 759362009789 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 759362009790 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 759362009791 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 759362009792 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 759362009793 catalytic loop [active] 759362009794 iron binding site [ion binding]; other site 759362009795 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 759362009796 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 759362009797 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362009798 Walker A/P-loop; other site 759362009799 ATP binding site [chemical binding]; other site 759362009800 Q-loop/lid; other site 759362009801 ABC transporter signature motif; other site 759362009802 Walker B; other site 759362009803 D-loop; other site 759362009804 H-loop/switch region; other site 759362009805 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 759362009806 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 759362009807 Walker A/P-loop; other site 759362009808 ATP binding site [chemical binding]; other site 759362009809 Q-loop/lid; other site 759362009810 ABC transporter signature motif; other site 759362009811 Walker B; other site 759362009812 D-loop; other site 759362009813 H-loop/switch region; other site 759362009814 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 759362009815 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 759362009816 homotrimer interaction site [polypeptide binding]; other site 759362009817 putative active site [active] 759362009818 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 759362009819 homotrimer interaction site [polypeptide binding]; other site 759362009820 putative active site [active] 759362009821 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 759362009822 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 759362009823 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362009824 dimer interface [polypeptide binding]; other site 759362009825 conserved gate region; other site 759362009826 putative PBP binding loops; other site 759362009827 ABC-ATPase subunit interface; other site 759362009828 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 759362009829 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 759362009830 dimer interface [polypeptide binding]; other site 759362009831 conserved gate region; other site 759362009832 putative PBP binding loops; other site 759362009833 ABC-ATPase subunit interface; other site 759362009834 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 759362009835 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 759362009836 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 759362009837 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 759362009838 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; cl19223 759362009839 Transcriptional regulator [Transcription]; Region: LysR; COG0583 759362009840 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 759362009841 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 759362009842 putative effector binding pocket; other site 759362009843 putative dimerization interface [polypeptide binding]; other site 759362009844 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 759362009845 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 759362009846 active site 759362009847 catalytic tetrad [active] 759362009848 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 759362009849 Major Facilitator Superfamily; Region: MFS_1; pfam07690 759362009850 putative substrate translocation pore; other site