-- dump date 20140619_120618 -- class Genbank::misc_feature -- table misc_feature_note -- id note 266940000001 AAA domain; Region: AAA_25; pfam13481 266940000002 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 266940000003 Walker A motif; other site 266940000004 ATP binding site [chemical binding]; other site 266940000005 Walker B motif; other site 266940000006 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266940000007 sequence-specific DNA binding site [nucleotide binding]; other site 266940000008 salt bridge; other site 266940000009 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 266940000010 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 266940000011 catalytic residues [active] 266940000012 catalytic nucleophile [active] 266940000013 Presynaptic Site I dimer interface [polypeptide binding]; other site 266940000014 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 266940000015 Synaptic Flat tetramer interface [polypeptide binding]; other site 266940000016 Synaptic Site I dimer interface [polypeptide binding]; other site 266940000017 DNA binding site [nucleotide binding] 266940000018 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 266940000019 DNA-binding interface [nucleotide binding]; DNA binding site 266940000020 hypothetical protein; Region: PHA01623 266940000021 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 266940000022 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266940000023 P-loop; other site 266940000024 Magnesium ion binding site [ion binding]; other site 266940000025 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266940000026 Magnesium ion binding site [ion binding]; other site 266940000027 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266940000028 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266940000029 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266940000030 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266940000031 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940000032 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266940000033 NAD(P) binding site [chemical binding]; other site 266940000034 active site 266940000035 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR8; cd08273 266940000036 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266940000037 putative NAD(P) binding site [chemical binding]; other site 266940000038 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266940000039 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266940000040 short chain dehydrogenase; Provisional; Region: PRK09291 266940000041 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940000042 NAD(P) binding site [chemical binding]; other site 266940000043 active site 266940000044 Domain of unknown function (DUF385); Region: DUF385; cl04387 266940000045 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266940000046 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 266940000047 putative NAD(P) binding site [chemical binding]; other site 266940000048 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 266940000049 tetracycline repressor protein TetR; Provisional; Region: PRK13756 266940000050 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266940000051 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 266940000052 Helix-turn-helix domain; Region: HTH_31; pfam13560 266940000053 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266940000054 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 266940000055 putative NAD(P) binding site [chemical binding]; other site 266940000056 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 266940000057 NmrA-like family; Region: NmrA; pfam05368 266940000058 NADP binding site [chemical binding]; other site 266940000059 active site 266940000060 regulatory binding site [polypeptide binding]; other site 266940000061 FAD binding domain; Region: FAD_binding_4; pfam01565 266940000062 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266940000063 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 266940000064 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266940000065 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266940000066 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 266940000067 GAF domain; Region: GAF; pfam01590 266940000068 GAF domain; Region: GAF_2; pfam13185 266940000069 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940000070 metal binding site [ion binding]; metal-binding site 266940000071 active site 266940000072 I-site; other site 266940000073 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266940000074 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 266940000075 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 266940000076 anti sigma factor interaction site; other site 266940000077 regulatory phosphorylation site [posttranslational modification]; other site 266940000078 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 266940000079 putative active site [active] 266940000080 catalytic site [active] 266940000081 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 266940000082 putative active site [active] 266940000083 catalytic site [active] 266940000084 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 266940000085 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 266940000086 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 266940000087 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 266940000088 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 266940000089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266940000090 S-adenosylmethionine binding site [chemical binding]; other site 266940000091 Protein of unknown function (DUF1330); Region: DUF1330; pfam07045 266940000092 short chain dehydrogenase; Provisional; Region: PRK06523 266940000093 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940000094 NAD(P) binding site [chemical binding]; other site 266940000095 active site 266940000096 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266940000097 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266940000098 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266940000099 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266940000100 TAP-like protein; Region: Abhydrolase_4; pfam08386 266940000101 hypothetical protein; Provisional; Region: PRK06761 266940000102 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 266940000103 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 266940000104 DNA binding residues [nucleotide binding] 266940000105 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 266940000106 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266940000107 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266940000108 short chain dehydrogenase; Validated; Region: PRK08264 266940000109 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940000110 NAD(P) binding site [chemical binding]; other site 266940000111 active site 266940000112 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266940000113 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 266940000114 AsnC family; Region: AsnC_trans_reg; pfam01037 266940000115 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 266940000116 acetylornithine deacetylase; Validated; Region: PRK06915 266940000117 metal binding site [ion binding]; metal-binding site 266940000118 dimer interface [polypeptide binding]; other site 266940000119 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 266940000120 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 266940000121 active site 266940000122 non-prolyl cis peptide bond; other site 266940000123 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266940000124 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 266940000125 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266940000126 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940000127 dimer interface [polypeptide binding]; other site 266940000128 conserved gate region; other site 266940000129 putative PBP binding loops; other site 266940000130 ABC-ATPase subunit interface; other site 266940000131 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266940000132 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940000133 dimer interface [polypeptide binding]; other site 266940000134 conserved gate region; other site 266940000135 putative PBP binding loops; other site 266940000136 ABC-ATPase subunit interface; other site 266940000137 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 266940000138 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266940000139 Walker A/P-loop; other site 266940000140 ATP binding site [chemical binding]; other site 266940000141 Q-loop/lid; other site 266940000142 ABC transporter signature motif; other site 266940000143 Walker B; other site 266940000144 D-loop; other site 266940000145 H-loop/switch region; other site 266940000146 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266940000147 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266940000148 Walker A/P-loop; other site 266940000149 ATP binding site [chemical binding]; other site 266940000150 Q-loop/lid; other site 266940000151 ABC transporter signature motif; other site 266940000152 Walker B; other site 266940000153 D-loop; other site 266940000154 H-loop/switch region; other site 266940000155 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266940000156 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 266940000157 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 266940000158 active site 266940000159 non-prolyl cis peptide bond; other site 266940000160 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266940000161 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940000162 dimer interface [polypeptide binding]; other site 266940000163 conserved gate region; other site 266940000164 putative PBP binding loops; other site 266940000165 ABC-ATPase subunit interface; other site 266940000166 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 266940000167 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266940000168 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266940000169 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266940000170 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266940000171 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 266940000172 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 266940000173 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 266940000174 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 266940000175 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 266940000176 dimer interface [polypeptide binding]; other site 266940000177 active site 266940000178 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 266940000179 dimer interface [polypeptide binding]; other site 266940000180 active site 266940000181 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 266940000182 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 266940000183 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266940000184 active site 266940000185 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 266940000186 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 266940000187 putative substrate binding site [chemical binding]; other site 266940000188 putative ATP binding site [chemical binding]; other site 266940000189 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 266940000190 intersubunit interface [polypeptide binding]; other site 266940000191 active site 266940000192 zinc binding site [ion binding]; other site 266940000193 Na+ binding site [ion binding]; other site 266940000194 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 266940000195 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 266940000196 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 266940000197 short chain dehydrogenase; Validated; Region: PRK08264 266940000198 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940000199 NAD(P) binding site [chemical binding]; other site 266940000200 active site 266940000201 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 266940000202 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 266940000203 DNA binding residues [nucleotide binding] 266940000204 putative dimer interface [polypeptide binding]; other site 266940000205 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 266940000206 oligomeric interface; other site 266940000207 putative active site [active] 266940000208 homodimer interface [polypeptide binding]; other site 266940000209 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 266940000210 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 266940000211 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 266940000212 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 266940000213 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 266940000214 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 266940000215 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266940000216 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266940000217 DNA-binding site [nucleotide binding]; DNA binding site 266940000218 FCD domain; Region: FCD; pfam07729 266940000219 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266940000220 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266940000221 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266940000222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940000223 putative PBP binding loops; other site 266940000224 dimer interface [polypeptide binding]; other site 266940000225 ABC-ATPase subunit interface; other site 266940000226 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266940000227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940000228 dimer interface [polypeptide binding]; other site 266940000229 conserved gate region; other site 266940000230 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266940000231 ABC-ATPase subunit interface; other site 266940000232 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 266940000233 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 266940000234 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 266940000235 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 266940000236 NAD binding site [chemical binding]; other site 266940000237 ligand binding site [chemical binding]; other site 266940000238 catalytic site [active] 266940000239 Methyltransferase domain; Region: Methyltransf_31; pfam13847 266940000240 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266940000241 S-adenosylmethionine binding site [chemical binding]; other site 266940000242 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 266940000243 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266940000244 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266940000245 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266940000246 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 266940000247 putative dimerization interface [polypeptide binding]; other site 266940000248 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 266940000249 active site 266940000250 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940000251 NADH(P)-binding; Region: NAD_binding_10; pfam13460 266940000252 NAD(P) binding site [chemical binding]; other site 266940000253 active site 266940000254 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 266940000255 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 266940000256 active site 266940000257 intersubunit interface [polypeptide binding]; other site 266940000258 catalytic residue [active] 266940000259 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 266940000260 substrate binding site [chemical binding]; other site 266940000261 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266940000262 ATP binding site [chemical binding]; other site 266940000263 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 266940000264 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 266940000265 putative NAD(P) binding site [chemical binding]; other site 266940000266 catalytic Zn binding site [ion binding]; other site 266940000267 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940000268 metabolite-proton symporter; Region: 2A0106; TIGR00883 266940000269 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 266940000270 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 266940000271 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 266940000272 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 266940000273 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 266940000274 metal binding site [ion binding]; metal-binding site 266940000275 substrate binding pocket [chemical binding]; other site 266940000276 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266940000277 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266940000278 DNA-binding site [nucleotide binding]; DNA binding site 266940000279 FCD domain; Region: FCD; pfam07729 266940000280 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 266940000281 active site 266940000282 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266940000283 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 266940000284 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 266940000285 TM-ABC transporter signature motif; other site 266940000286 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 266940000287 TM-ABC transporter signature motif; other site 266940000288 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 266940000289 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266940000290 Walker A/P-loop; other site 266940000291 ATP binding site [chemical binding]; other site 266940000292 Q-loop/lid; other site 266940000293 ABC transporter signature motif; other site 266940000294 Walker B; other site 266940000295 D-loop; other site 266940000296 H-loop/switch region; other site 266940000297 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266940000298 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 266940000299 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 266940000300 ligand binding site [chemical binding]; other site 266940000301 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266940000302 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266940000303 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 266940000304 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 266940000305 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266940000306 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 266940000307 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266940000308 putative NAD(P) binding site [chemical binding]; other site 266940000309 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 266940000310 homotetrameric interface [polypeptide binding]; other site 266940000311 putative active site [active] 266940000312 metal binding site [ion binding]; metal-binding site 266940000313 Sporulation and spore germination; Region: Germane; pfam10646 266940000314 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266940000315 dimerization interface [polypeptide binding]; other site 266940000316 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266940000317 dimer interface [polypeptide binding]; other site 266940000318 phosphorylation site [posttranslational modification] 266940000319 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266940000320 ATP binding site [chemical binding]; other site 266940000321 Mg2+ binding site [ion binding]; other site 266940000322 G-X-G motif; other site 266940000323 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266940000324 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266940000325 active site 266940000326 phosphorylation site [posttranslational modification] 266940000327 intermolecular recognition site; other site 266940000328 dimerization interface [polypeptide binding]; other site 266940000329 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266940000330 DNA binding site [nucleotide binding] 266940000331 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 266940000332 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 266940000333 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 266940000334 Predicted membrane protein [Function unknown]; Region: COG1971 266940000335 Domain of unknown function DUF; Region: DUF204; pfam02659 266940000336 Uncharacterized conserved protein [Function unknown]; Region: COG4850 266940000337 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 266940000338 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266940000339 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266940000340 Uncharacterized conserved protein [Function unknown]; Region: COG3268 266940000341 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940000342 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266940000343 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 266940000344 GAF domain; Region: GAF; pfam01590 266940000345 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940000346 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940000347 metal binding site [ion binding]; metal-binding site 266940000348 active site 266940000349 I-site; other site 266940000350 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 266940000351 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266940000352 dimerization interface [polypeptide binding]; other site 266940000353 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266940000354 dimer interface [polypeptide binding]; other site 266940000355 putative CheW interface [polypeptide binding]; other site 266940000356 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 266940000357 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940000358 Walker A/P-loop; other site 266940000359 ATP binding site [chemical binding]; other site 266940000360 Q-loop/lid; other site 266940000361 ABC transporter signature motif; other site 266940000362 Walker B; other site 266940000363 D-loop; other site 266940000364 H-loop/switch region; other site 266940000365 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 266940000366 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940000367 Walker A/P-loop; other site 266940000368 ATP binding site [chemical binding]; other site 266940000369 Q-loop/lid; other site 266940000370 ABC transporter signature motif; other site 266940000371 Walker B; other site 266940000372 D-loop; other site 266940000373 H-loop/switch region; other site 266940000374 TOBE domain; Region: TOBE_2; pfam08402 266940000375 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266940000376 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940000377 dimer interface [polypeptide binding]; other site 266940000378 conserved gate region; other site 266940000379 ABC-ATPase subunit interface; other site 266940000380 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266940000381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940000382 dimer interface [polypeptide binding]; other site 266940000383 conserved gate region; other site 266940000384 putative PBP binding loops; other site 266940000385 ABC-ATPase subunit interface; other site 266940000386 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266940000387 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 266940000388 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 266940000389 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH2; cd08256 266940000390 putative NAD(P) binding site [chemical binding]; other site 266940000391 catalytic Zn binding site [ion binding]; other site 266940000392 structural Zn binding site [ion binding]; other site 266940000393 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 266940000394 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 266940000395 non-specific DNA interactions [nucleotide binding]; other site 266940000396 DNA binding site [nucleotide binding] 266940000397 sequence specific DNA binding site [nucleotide binding]; other site 266940000398 putative cAMP binding site [chemical binding]; other site 266940000399 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 266940000400 short chain dehydrogenase; Provisional; Region: PRK07060 266940000401 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940000402 NAD(P) binding site [chemical binding]; other site 266940000403 active site 266940000404 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 266940000405 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 266940000406 N- and C-terminal domain interface [polypeptide binding]; other site 266940000407 putative active site [active] 266940000408 MgATP binding site [chemical binding]; other site 266940000409 catalytic site [active] 266940000410 metal binding site [ion binding]; metal-binding site 266940000411 putative xylulose binding site [chemical binding]; other site 266940000412 putative homodimer interface [polypeptide binding]; other site 266940000413 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266940000414 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266940000415 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 266940000416 Domain of unknown function (DUF385); Region: DUF385; cl04387 266940000417 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266940000418 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266940000419 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 266940000420 Amidase; Region: Amidase; cl11426 266940000421 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 266940000422 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 266940000423 allantoate amidohydrolase; Reviewed; Region: PRK09290 266940000424 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 266940000425 active site 266940000426 metal binding site [ion binding]; metal-binding site 266940000427 dimer interface [polypeptide binding]; other site 266940000428 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 266940000429 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 266940000430 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266940000431 catalytic residue [active] 266940000432 allantoinase; Region: allantoinase; TIGR03178 266940000433 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266940000434 active site 266940000435 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 266940000436 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 266940000437 XdhC Rossmann domain; Region: XdhC_C; pfam13478 266940000438 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 266940000439 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266940000440 catalytic loop [active] 266940000441 iron binding site [ion binding]; other site 266940000442 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 266940000443 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 266940000444 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 266940000445 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266940000446 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 266940000447 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 266940000448 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 266940000449 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 266940000450 nucleoside/Zn binding site; other site 266940000451 dimer interface [polypeptide binding]; other site 266940000452 catalytic motif [active] 266940000453 urate oxidase; Region: urate_oxi; TIGR03383 266940000454 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 266940000455 active site 266940000456 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 266940000457 active site 266940000458 homotetramer interface [polypeptide binding]; other site 266940000459 putative OHCU decarboxylase; Provisional; Region: PRK13798 266940000460 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 266940000461 metal-binding site 266940000462 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 266940000463 Na binding site [ion binding]; other site 266940000464 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 266940000465 nucleoside/Zn binding site; other site 266940000466 dimer interface [polypeptide binding]; other site 266940000467 catalytic motif [active] 266940000468 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 266940000469 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 266940000470 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 266940000471 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 266940000472 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 266940000473 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266940000474 active site 266940000475 Amidohydrolase; Region: Amidohydro_2; pfam04909 266940000476 active site 266940000477 MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044 266940000478 radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043 266940000479 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266940000480 FeS/SAM binding site; other site 266940000481 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266940000482 Coenzyme A binding pocket [chemical binding]; other site 266940000483 AIR synthase-related protein, MSMEG_0567 C-terminal family; Region: MSMEG_0567_Cter; TIGR04050 266940000484 AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192 266940000485 dimerization interface [polypeptide binding]; other site 266940000486 putative ATP binding site [chemical binding]; other site 266940000487 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 266940000488 Predicted amidohydrolase [General function prediction only]; Region: COG0388 266940000489 active site 266940000490 catalytic triad [active] 266940000491 dimer interface [polypeptide binding]; other site 266940000492 MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042 266940000493 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 266940000494 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266940000495 glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047 266940000496 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 266940000497 Predicted amidohydrolase [General function prediction only]; Region: COG0388 266940000498 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 266940000499 active site 266940000500 catalytic triad [active] 266940000501 dimer interface [polypeptide binding]; other site 266940000502 MoxR-like ATPases [General function prediction only]; Region: COG0714 266940000503 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 266940000504 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 266940000505 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 266940000506 metal ion-dependent adhesion site (MIDAS); other site 266940000507 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 266940000508 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940000509 NAD(P) binding site [chemical binding]; other site 266940000510 active site 266940000511 MarR family; Region: MarR_2; cl17246 266940000512 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266940000513 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 266940000514 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266940000515 dimerization interface [polypeptide binding]; other site 266940000516 putative DNA binding site [nucleotide binding]; other site 266940000517 putative Zn2+ binding site [ion binding]; other site 266940000518 H+ Antiporter protein; Region: 2A0121; TIGR00900 266940000519 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266940000520 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266940000521 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940000522 NAD(P) binding site [chemical binding]; other site 266940000523 active site 266940000524 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266940000525 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266940000526 non-specific DNA binding site [nucleotide binding]; other site 266940000527 salt bridge; other site 266940000528 sequence-specific DNA binding site [nucleotide binding]; other site 266940000529 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 266940000530 intracellular protease, PfpI family; Region: PfpI; TIGR01382 266940000531 proposed catalytic triad [active] 266940000532 conserved cys residue [active] 266940000533 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 266940000534 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 266940000535 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 266940000536 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 266940000537 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 266940000538 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 266940000539 RibD C-terminal domain; Region: RibD_C; cl17279 266940000540 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 266940000541 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 266940000542 PAS fold; Region: PAS_3; pfam08447 266940000543 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266940000544 heme pocket [chemical binding]; other site 266940000545 putative active site [active] 266940000546 PAS fold; Region: PAS_4; pfam08448 266940000547 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 266940000548 putative active site [active] 266940000549 heme pocket [chemical binding]; other site 266940000550 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 266940000551 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 266940000552 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 266940000553 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266940000554 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266940000555 salt bridge; other site 266940000556 non-specific DNA binding site [nucleotide binding]; other site 266940000557 sequence-specific DNA binding site [nucleotide binding]; other site 266940000558 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940000559 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266940000560 NAD(P) binding site [chemical binding]; other site 266940000561 active site 266940000562 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 266940000563 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940000564 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940000565 metal binding site [ion binding]; metal-binding site 266940000566 active site 266940000567 I-site; other site 266940000568 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266940000569 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 266940000570 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 266940000571 DNA binding residues [nucleotide binding] 266940000572 drug binding residues [chemical binding]; other site 266940000573 dimer interface [polypeptide binding]; other site 266940000574 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 266940000575 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 266940000576 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940000577 Walker A/P-loop; other site 266940000578 ATP binding site [chemical binding]; other site 266940000579 Q-loop/lid; other site 266940000580 ABC transporter signature motif; other site 266940000581 Walker B; other site 266940000582 D-loop; other site 266940000583 H-loop/switch region; other site 266940000584 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 266940000585 ABC-2 type transporter; Region: ABC2_membrane; cl17235 266940000586 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 266940000587 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 266940000588 DNA binding residues [nucleotide binding] 266940000589 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 266940000590 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 266940000591 inhibitor site; inhibition site 266940000592 active site 266940000593 dimer interface [polypeptide binding]; other site 266940000594 catalytic residue [active] 266940000595 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 266940000596 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 266940000597 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940000598 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940000599 metal binding site [ion binding]; metal-binding site 266940000600 active site 266940000601 I-site; other site 266940000602 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 266940000603 GAF domain; Region: GAF; pfam01590 266940000604 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266940000605 GAF domain; Region: GAF; cl17456 266940000606 PAS fold; Region: PAS_3; pfam08447 266940000607 PAS fold; Region: PAS_4; pfam08448 266940000608 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266940000609 putative active site [active] 266940000610 heme pocket [chemical binding]; other site 266940000611 GAF domain; Region: GAF; cl17456 266940000612 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 266940000613 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940000614 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940000615 metal binding site [ion binding]; metal-binding site 266940000616 active site 266940000617 I-site; other site 266940000618 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266940000619 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 266940000620 GAF domain; Region: GAF; pfam01590 266940000621 PAS domain S-box; Region: sensory_box; TIGR00229 266940000622 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266940000623 putative active site [active] 266940000624 heme pocket [chemical binding]; other site 266940000625 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266940000626 PAS domain; Region: PAS_9; pfam13426 266940000627 putative active site [active] 266940000628 heme pocket [chemical binding]; other site 266940000629 PAS domain S-box; Region: sensory_box; TIGR00229 266940000630 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266940000631 putative active site [active] 266940000632 heme pocket [chemical binding]; other site 266940000633 PAS domain; Region: PAS; smart00091 266940000634 GAF domain; Region: GAF_2; pfam13185 266940000635 GAF domain; Region: GAF; pfam01590 266940000636 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 266940000637 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 266940000638 IHF - DNA interface [nucleotide binding]; other site 266940000639 IHF dimer interface [polypeptide binding]; other site 266940000640 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 266940000641 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 266940000642 Walker A/P-loop; other site 266940000643 ATP binding site [chemical binding]; other site 266940000644 Q-loop/lid; other site 266940000645 ABC transporter signature motif; other site 266940000646 Walker B; other site 266940000647 D-loop; other site 266940000648 H-loop/switch region; other site 266940000649 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 266940000650 Histidine kinase; Region: HisKA_3; pfam07730 266940000651 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266940000652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266940000653 active site 266940000654 phosphorylation site [posttranslational modification] 266940000655 intermolecular recognition site; other site 266940000656 dimerization interface [polypeptide binding]; other site 266940000657 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266940000658 DNA binding residues [nucleotide binding] 266940000659 dimerization interface [polypeptide binding]; other site 266940000660 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266940000661 non-specific DNA binding site [nucleotide binding]; other site 266940000662 salt bridge; other site 266940000663 sequence-specific DNA binding site [nucleotide binding]; other site 266940000664 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266940000665 acetyl-CoA decarbonylase/synthase complex subunit gamma; Provisional; Region: PRK04165 266940000666 Putative sensor; Region: Sensor; pfam13796 266940000667 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 266940000668 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266940000669 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266940000670 active site 266940000671 phosphorylation site [posttranslational modification] 266940000672 intermolecular recognition site; other site 266940000673 dimerization interface [polypeptide binding]; other site 266940000674 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266940000675 DNA binding residues [nucleotide binding] 266940000676 PRC-barrel domain; Region: PRC; pfam05239 266940000677 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 266940000678 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266940000679 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 266940000680 active site 266940000681 NTP binding site [chemical binding]; other site 266940000682 metal binding triad [ion binding]; metal-binding site 266940000683 PAS fold; Region: PAS_2; pfam08446 266940000684 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 266940000685 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 266940000686 Phytochrome region; Region: PHY; pfam00360 266940000687 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 266940000688 Phosphotransferase enzyme family; Region: APH; pfam01636 266940000689 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 266940000690 active site 266940000691 ATP binding site [chemical binding]; other site 266940000692 substrate binding site [chemical binding]; other site 266940000693 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266940000694 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266940000695 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 266940000696 ligand binding site [chemical binding]; other site 266940000697 dimerization interface [polypeptide binding]; other site 266940000698 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940000699 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940000700 metal binding site [ion binding]; metal-binding site 266940000701 active site 266940000702 I-site; other site 266940000703 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266940000704 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266940000705 active site 266940000706 phosphorylation site [posttranslational modification] 266940000707 intermolecular recognition site; other site 266940000708 dimerization interface [polypeptide binding]; other site 266940000709 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266940000710 DNA binding residues [nucleotide binding] 266940000711 dimerization interface [polypeptide binding]; other site 266940000712 Histidine kinase; Region: HisKA_3; pfam07730 266940000713 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 266940000714 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 266940000715 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 266940000716 Walker A/P-loop; other site 266940000717 ATP binding site [chemical binding]; other site 266940000718 Q-loop/lid; other site 266940000719 ABC transporter signature motif; other site 266940000720 Walker B; other site 266940000721 D-loop; other site 266940000722 H-loop/switch region; other site 266940000723 Predicted amidohydrolase [General function prediction only]; Region: COG0388 266940000724 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 266940000725 active site 266940000726 catalytic triad [active] 266940000727 dimer interface [polypeptide binding]; other site 266940000728 hydrophobic ligand binding site; other site 266940000729 Activator of Hsp90 ATPase homolog 1-like protein; Region: AHSA1; pfam08327 266940000730 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266940000731 dimerization interface [polypeptide binding]; other site 266940000732 putative DNA binding site [nucleotide binding]; other site 266940000733 putative Zn2+ binding site [ion binding]; other site 266940000734 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266940000735 active site 266940000736 ATP binding site [chemical binding]; other site 266940000737 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266940000738 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 266940000739 Beta-lactamase; Region: Beta-lactamase; pfam00144 266940000740 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 266940000741 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 266940000742 LGFP repeat; Region: LGFP; pfam08310 266940000743 LGFP repeat; Region: LGFP; pfam08310 266940000744 FtsX-like permease family; Region: FtsX; pfam02687 266940000745 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 266940000746 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 266940000747 Walker A/P-loop; other site 266940000748 ATP binding site [chemical binding]; other site 266940000749 Q-loop/lid; other site 266940000750 ABC transporter signature motif; other site 266940000751 Walker B; other site 266940000752 D-loop; other site 266940000753 H-loop/switch region; other site 266940000754 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 266940000755 HTH domain; Region: HTH_11; pfam08279 266940000756 WYL domain; Region: WYL; pfam13280 266940000757 Dienelactone hydrolase family; Region: DLH; pfam01738 266940000758 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266940000759 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266940000760 sequence-specific DNA binding site [nucleotide binding]; other site 266940000761 salt bridge; other site 266940000762 Predicted acetyltransferase [General function prediction only]; Region: COG2388 266940000763 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 266940000764 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940000765 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266940000766 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 266940000767 putative NAD(P) binding site [chemical binding]; other site 266940000768 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 266940000769 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 266940000770 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266940000771 non-specific DNA binding site [nucleotide binding]; other site 266940000772 salt bridge; other site 266940000773 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266940000774 sequence-specific DNA binding site [nucleotide binding]; other site 266940000775 hypothetical protein; Provisional; Region: PRK08204 266940000776 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266940000777 active site 266940000778 short chain dehydrogenase; Provisional; Region: PRK06180 266940000779 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 266940000780 NADP binding site [chemical binding]; other site 266940000781 active site 266940000782 steroid binding site; other site 266940000783 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 266940000784 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940000785 NAD(P) binding site [chemical binding]; other site 266940000786 active site 266940000787 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 266940000788 Predicted transcriptional regulators [Transcription]; Region: COG1695 266940000789 Transcriptional regulator PadR-like family; Region: PadR; cl17335 266940000790 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 266940000791 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 266940000792 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 266940000793 substrate binding pocket [chemical binding]; other site 266940000794 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266940000795 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 266940000796 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 266940000797 putative active site [active] 266940000798 putative metal binding site [ion binding]; other site 266940000799 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 266940000800 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 266940000801 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 266940000802 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 266940000803 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 266940000804 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 266940000805 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 266940000806 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266940000807 dimerization interface [polypeptide binding]; other site 266940000808 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 266940000809 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266940000810 dimer interface [polypeptide binding]; other site 266940000811 putative CheW interface [polypeptide binding]; other site 266940000812 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940000813 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940000814 metal binding site [ion binding]; metal-binding site 266940000815 active site 266940000816 I-site; other site 266940000817 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266940000818 MarR family; Region: MarR_2; pfam12802 266940000819 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 266940000820 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 266940000821 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 266940000822 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 266940000823 GAF domain; Region: GAF_2; pfam13185 266940000824 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 266940000825 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 266940000826 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266940000827 dimer interface [polypeptide binding]; other site 266940000828 putative CheW interface [polypeptide binding]; other site 266940000829 Fic/DOC family; Region: Fic; cl00960 266940000830 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 266940000831 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 266940000832 hypothetical protein; Provisional; Region: PRK07906 266940000833 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 266940000834 putative metal binding site [ion binding]; other site 266940000835 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266940000836 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266940000837 DNA-binding site [nucleotide binding]; DNA binding site 266940000838 FCD domain; Region: FCD; pfam07729 266940000839 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 266940000840 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 266940000841 DNA interaction; other site 266940000842 Metal-binding active site; metal-binding site 266940000843 dihydroxyacetone kinase; Provisional; Region: PRK14479 266940000844 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 266940000845 DAK2 domain; Region: Dak2; pfam02734 266940000846 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 266940000847 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 266940000848 triosephosphate isomerase; Provisional; Region: PRK14565 266940000849 substrate binding site [chemical binding]; other site 266940000850 dimer interface [polypeptide binding]; other site 266940000851 catalytic triad [active] 266940000852 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 266940000853 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 266940000854 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266940000855 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 266940000856 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 266940000857 DNA binding residues [nucleotide binding] 266940000858 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 266940000859 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 266940000860 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266940000861 dimerization interface [polypeptide binding]; other site 266940000862 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 266940000863 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266940000864 dimer interface [polypeptide binding]; other site 266940000865 putative CheW interface [polypeptide binding]; other site 266940000866 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 266940000867 HAMP domain; Region: HAMP; pfam00672 266940000868 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266940000869 dimer interface [polypeptide binding]; other site 266940000870 putative CheW interface [polypeptide binding]; other site 266940000871 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266940000872 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266940000873 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 266940000874 iron-sulfur cluster [ion binding]; other site 266940000875 [2Fe-2S] cluster binding site [ion binding]; other site 266940000876 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 266940000877 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266940000878 active site 266940000879 DNA binding site [nucleotide binding] 266940000880 Int/Topo IB signature motif; other site 266940000881 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 266940000882 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 266940000883 ATP binding site [chemical binding]; other site 266940000884 substrate interface [chemical binding]; other site 266940000885 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 266940000886 active site residue [active] 266940000887 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 266940000888 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940000889 putative substrate translocation pore; other site 266940000890 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 266940000891 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 266940000892 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 266940000893 active site 266940000894 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 266940000895 FMN binding site [chemical binding]; other site 266940000896 dimer interface [polypeptide binding]; other site 266940000897 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 266940000898 dimer interface [polypeptide binding]; other site 266940000899 Protein of unknown function (DUF1059); Region: DUF1059; pfam06348 266940000900 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 266940000901 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 266940000902 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 266940000903 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 266940000904 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 266940000905 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 266940000906 putative active site [active] 266940000907 catalytic site [active] 266940000908 putative metal binding site [ion binding]; other site 266940000909 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 266940000910 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 266940000911 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 266940000912 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 266940000913 DENN (AEX-3) domain; Region: DENN; cl11519 266940000914 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 266940000915 putative active site [active] 266940000916 catalytic triad [active] 266940000917 putative dimer interface [polypeptide binding]; other site 266940000918 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 266940000919 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266940000920 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266940000921 active site 266940000922 5'-3' exonuclease; Region: 53EXOc; smart00475 266940000923 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 266940000924 active site 266940000925 metal binding site 1 [ion binding]; metal-binding site 266940000926 putative 5' ssDNA interaction site; other site 266940000927 metal binding site 3; metal-binding site 266940000928 metal binding site 2 [ion binding]; metal-binding site 266940000929 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 266940000930 putative DNA binding site [nucleotide binding]; other site 266940000931 putative metal binding site [ion binding]; other site 266940000932 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266940000933 S-adenosylmethionine binding site [chemical binding]; other site 266940000934 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 266940000935 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266940000936 ATP binding site [chemical binding]; other site 266940000937 putative Mg++ binding site [ion binding]; other site 266940000938 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266940000939 nucleotide binding region [chemical binding]; other site 266940000940 ATP-binding site [chemical binding]; other site 266940000941 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 266940000942 diacylglycerol kinase; Reviewed; Region: PRK11914 266940000943 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 266940000944 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 266940000945 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 266940000946 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 266940000947 Predicted transcriptional regulator [Transcription]; Region: COG2378 266940000948 WYL domain; Region: WYL; pfam13280 266940000949 Predicted transcriptional regulator [Transcription]; Region: COG2378 266940000950 WYL domain; Region: WYL; pfam13280 266940000951 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982 266940000952 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 266940000953 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 266940000954 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 266940000955 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 266940000956 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 266940000957 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 266940000958 active site 266940000959 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 266940000960 active site 266940000961 Pup-like protein; Region: Pup; pfam05639 266940000962 Pup-ligase protein; Region: Pup_ligase; cl15463 266940000963 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 266940000964 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 266940000965 FtsX-like permease family; Region: FtsX; pfam02687 266940000966 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 266940000967 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 266940000968 Walker A/P-loop; other site 266940000969 ATP binding site [chemical binding]; other site 266940000970 Q-loop/lid; other site 266940000971 ABC transporter signature motif; other site 266940000972 Walker B; other site 266940000973 D-loop; other site 266940000974 H-loop/switch region; other site 266940000975 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 266940000976 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 266940000977 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 266940000978 nudix motif; other site 266940000979 proteasome ATPase; Region: pup_AAA; TIGR03689 266940000980 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266940000981 Walker A motif; other site 266940000982 ATP binding site [chemical binding]; other site 266940000983 Walker B motif; other site 266940000984 arginine finger; other site 266940000985 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266940000986 kynureninase; Region: kynureninase; TIGR01814 266940000987 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266940000988 catalytic residue [active] 266940000989 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 266940000990 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 266940000991 Sodium Bile acid symporter family; Region: SBF; cl17470 266940000992 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 266940000993 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 266940000994 active site residue [active] 266940000995 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 266940000996 active site residue [active] 266940000997 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266940000998 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266940000999 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 266940001000 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 266940001001 conserved cys residue [active] 266940001002 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 266940001003 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266940001004 S-adenosylmethionine binding site [chemical binding]; other site 266940001005 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 266940001006 active site 266940001007 putative substrate binding region [chemical binding]; other site 266940001008 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 266940001009 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 266940001010 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266940001011 dimer interface [polypeptide binding]; other site 266940001012 putative CheW interface [polypeptide binding]; other site 266940001013 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266940001014 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266940001015 active site 266940001016 phosphorylation site [posttranslational modification] 266940001017 intermolecular recognition site; other site 266940001018 dimerization interface [polypeptide binding]; other site 266940001019 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 266940001020 putative binding surface; other site 266940001021 active site 266940001022 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 266940001023 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 266940001024 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266940001025 ATP binding site [chemical binding]; other site 266940001026 Mg2+ binding site [ion binding]; other site 266940001027 G-X-G motif; other site 266940001028 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 266940001029 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266940001030 Response regulator receiver domain; Region: Response_reg; pfam00072 266940001031 active site 266940001032 phosphorylation site [posttranslational modification] 266940001033 intermolecular recognition site; other site 266940001034 dimerization interface [polypeptide binding]; other site 266940001035 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 266940001036 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 266940001037 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 266940001038 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 266940001039 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266940001040 active site 266940001041 phosphorylation site [posttranslational modification] 266940001042 intermolecular recognition site; other site 266940001043 dimerization interface [polypeptide binding]; other site 266940001044 CheB methylesterase; Region: CheB_methylest; pfam01339 266940001045 CheW-like domain; Region: CheW; pfam01584 266940001046 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 266940001047 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 266940001048 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266940001049 dimer interface [polypeptide binding]; other site 266940001050 putative CheW interface [polypeptide binding]; other site 266940001051 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266940001052 dimer interface [polypeptide binding]; other site 266940001053 putative CheW interface [polypeptide binding]; other site 266940001054 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 266940001055 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266940001056 PAC2 family; Region: PAC2; pfam09754 266940001057 Protein of unknown function (DUF805); Region: DUF805; pfam05656 266940001058 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 266940001059 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 266940001060 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 266940001061 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 266940001062 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 266940001063 active site 266940001064 dimer interface [polypeptide binding]; other site 266940001065 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266940001066 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 266940001067 active site 266940001068 HIGH motif; other site 266940001069 nucleotide binding site [chemical binding]; other site 266940001070 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266940001071 active site 266940001072 KMSKS motif; other site 266940001073 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 266940001074 putative tRNA binding surface [nucleotide binding]; other site 266940001075 conserved hypothetical protein; Region: TIGR03843 266940001076 Protein of unknown function (DUF3090); Region: DUF3090; pfam11290 266940001077 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266940001078 catalytic core [active] 266940001079 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 266940001080 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 266940001081 oligomer interface [polypeptide binding]; other site 266940001082 metal binding site [ion binding]; metal-binding site 266940001083 metal binding site [ion binding]; metal-binding site 266940001084 putative Cl binding site [ion binding]; other site 266940001085 basic sphincter; other site 266940001086 hydrophobic gate; other site 266940001087 periplasmic entrance; other site 266940001088 Glycoside hydrolase family 71; Region: GH71; cd11577 266940001089 putative ligand binding site [chemical binding]; other site 266940001090 Glycoside hydrolase families 71, 99, and related domains; Region: GH99_GH71_like; cl01529 266940001091 putative catalytic site [active] 266940001092 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266940001093 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266940001094 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 266940001095 putative trimer interface [polypeptide binding]; other site 266940001096 putative active site [active] 266940001097 putative substrate binding site [chemical binding]; other site 266940001098 putative CoA binding site [chemical binding]; other site 266940001099 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 266940001100 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 266940001101 NADP binding site [chemical binding]; other site 266940001102 active site 266940001103 putative substrate binding site [chemical binding]; other site 266940001104 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 266940001105 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 266940001106 NADP-binding site; other site 266940001107 homotetramer interface [polypeptide binding]; other site 266940001108 substrate binding site [chemical binding]; other site 266940001109 homodimer interface [polypeptide binding]; other site 266940001110 active site 266940001111 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 266940001112 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 266940001113 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266940001114 active site 266940001115 nucleotide binding site [chemical binding]; other site 266940001116 HIGH motif; other site 266940001117 KMSKS motif; other site 266940001118 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266940001119 active site 266940001120 HIGH motif; other site 266940001121 nucleotide binding site [chemical binding]; other site 266940001122 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 266940001123 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 266940001124 active site 266940001125 Chain length determinant protein; Region: Wzz; cl15801 266940001126 putative glycosyl transferase; Provisional; Region: PRK10307 266940001127 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 266940001128 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 266940001129 amino acid transporter; Region: 2A0306; TIGR00909 266940001130 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 266940001131 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 266940001132 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 266940001133 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 266940001134 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266940001135 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940001136 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 266940001137 Walker A/P-loop; other site 266940001138 ATP binding site [chemical binding]; other site 266940001139 Q-loop/lid; other site 266940001140 ABC transporter signature motif; other site 266940001141 Walker B; other site 266940001142 D-loop; other site 266940001143 H-loop/switch region; other site 266940001144 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 266940001145 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 266940001146 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 266940001147 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266940001148 Walker A motif; other site 266940001149 ATP binding site [chemical binding]; other site 266940001150 Walker B motif; other site 266940001151 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 266940001152 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266940001153 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266940001154 dimer interface [polypeptide binding]; other site 266940001155 phosphorylation site [posttranslational modification] 266940001156 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266940001157 ATP binding site [chemical binding]; other site 266940001158 Mg2+ binding site [ion binding]; other site 266940001159 G-X-G motif; other site 266940001160 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266940001161 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266940001162 active site 266940001163 phosphorylation site [posttranslational modification] 266940001164 intermolecular recognition site; other site 266940001165 dimerization interface [polypeptide binding]; other site 266940001166 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266940001167 DNA binding site [nucleotide binding] 266940001168 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 266940001169 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 266940001170 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266940001171 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266940001172 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266940001173 catalytic residue [active] 266940001174 Putative zinc-finger; Region: zf-HC2; pfam13490 266940001175 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 266940001176 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266940001177 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266940001178 DNA binding residues [nucleotide binding] 266940001179 Phosphotransferase enzyme family; Region: APH; pfam01636 266940001180 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 266940001181 active site 266940001182 ATP binding site [chemical binding]; other site 266940001183 Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259 266940001184 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 266940001185 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 266940001186 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021 266940001187 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; pfam01036 266940001188 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 266940001189 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 266940001190 NAD binding site [chemical binding]; other site 266940001191 catalytic Zn binding site [ion binding]; other site 266940001192 structural Zn binding site [ion binding]; other site 266940001193 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 266940001194 active site 266940001195 Uncharacterized conserved protein [Function unknown]; Region: COG0397 266940001196 hypothetical protein; Validated; Region: PRK00029 266940001197 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 266940001198 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266940001199 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 266940001200 hypothetical protein; Provisional; Region: PRK10621 266940001201 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 266940001202 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940001203 Walker A/P-loop; other site 266940001204 ATP binding site [chemical binding]; other site 266940001205 Q-loop/lid; other site 266940001206 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940001207 ABC transporter signature motif; other site 266940001208 Walker B; other site 266940001209 D-loop; other site 266940001210 H-loop/switch region; other site 266940001211 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940001212 Walker A/P-loop; other site 266940001213 ATP binding site [chemical binding]; other site 266940001214 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940001215 Q-loop/lid; other site 266940001216 ABC transporter signature motif; other site 266940001217 Walker B; other site 266940001218 D-loop; other site 266940001219 H-loop/switch region; other site 266940001220 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 266940001221 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 266940001222 NAD(P) binding site [chemical binding]; other site 266940001223 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266940001224 active site 266940001225 PhoD-like phosphatase; Region: PhoD; pfam09423 266940001226 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 266940001227 putative active site [active] 266940001228 putative metal binding site [ion binding]; other site 266940001229 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 266940001230 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 266940001231 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 266940001232 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 266940001233 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 266940001234 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 266940001235 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 266940001236 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 266940001237 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266940001238 non-specific DNA binding site [nucleotide binding]; other site 266940001239 salt bridge; other site 266940001240 sequence-specific DNA binding site [nucleotide binding]; other site 266940001241 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266940001242 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266940001243 non-specific DNA binding site [nucleotide binding]; other site 266940001244 salt bridge; other site 266940001245 sequence-specific DNA binding site [nucleotide binding]; other site 266940001246 Helix-turn-helix domain; Region: HTH_17; pfam12728 266940001247 TraL protein; Region: TraL; cl06278 266940001248 DNA polymerase III subunit beta; Validated; Region: PRK07761 266940001249 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 266940001250 putative DNA binding surface [nucleotide binding]; other site 266940001251 dimer interface [polypeptide binding]; other site 266940001252 beta-clamp/clamp loader binding surface; other site 266940001253 beta-clamp/translesion DNA polymerase binding surface; other site 266940001254 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 266940001255 active site 266940001256 catalytic site [active] 266940001257 substrate binding site [chemical binding]; other site 266940001258 Transcription factor WhiB; Region: Whib; pfam02467 266940001259 ParB-like nuclease domain; Region: ParB; smart00470 266940001260 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 266940001261 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266940001262 DNA binding residues [nucleotide binding] 266940001263 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 266940001264 HNH endonuclease; Region: HNH_3; pfam13392 266940001265 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 266940001266 hypothetical protein; Region: PHA02451 266940001267 hypothetical protein; Region: PHA02451 266940001268 T5orf172 domain; Region: T5orf172; pfam10544 266940001269 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 266940001270 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 266940001271 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 266940001272 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 266940001273 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 266940001274 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 266940001275 Phage-related protein [Function unknown]; Region: COG5412 266940001276 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 266940001277 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266940001278 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266940001279 catalytic residue [active] 266940001280 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 266940001281 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 266940001282 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 266940001283 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 266940001284 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 266940001285 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266940001286 DNA binding residues [nucleotide binding] 266940001287 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 266940001288 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 266940001289 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 266940001290 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 266940001291 Int/Topo IB signature motif; other site 266940001292 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 266940001293 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266940001294 ATP binding site [chemical binding]; other site 266940001295 Walker A motif; other site 266940001296 Walker B motif; other site 266940001297 arginine finger; other site 266940001298 Protein of unknown function DUF58; Region: DUF58; pfam01882 266940001299 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 266940001300 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 266940001301 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258 266940001302 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 266940001303 dimer interface [polypeptide binding]; other site 266940001304 active site 266940001305 CoA binding pocket [chemical binding]; other site 266940001306 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266940001307 peptide synthase; Provisional; Region: PRK09274 266940001308 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266940001309 AMP binding site [chemical binding]; other site 266940001310 active site 266940001311 acyl-activating enzyme (AAE) consensus motif; other site 266940001312 CoA binding site [chemical binding]; other site 266940001313 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266940001314 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940001315 NAD(P) binding site [chemical binding]; other site 266940001316 active site 266940001317 Uncharacterized conserved protein [Function unknown]; Region: COG4850 266940001318 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 266940001319 PAS domain S-box; Region: sensory_box; TIGR00229 266940001320 PAS domain S-box; Region: sensory_box; TIGR00229 266940001321 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266940001322 putative active site [active] 266940001323 heme pocket [chemical binding]; other site 266940001324 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940001325 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940001326 metal binding site [ion binding]; metal-binding site 266940001327 active site 266940001328 I-site; other site 266940001329 Global regulator protein family; Region: CsrA; pfam02599 266940001330 PilZ domain; Region: PilZ; pfam07238 266940001331 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 266940001332 FHIPEP family; Region: FHIPEP; pfam00771 266940001333 Response regulator receiver domain; Region: Response_reg; pfam00072 266940001334 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266940001335 active site 266940001336 phosphorylation site [posttranslational modification] 266940001337 intermolecular recognition site; other site 266940001338 dimerization interface [polypeptide binding]; other site 266940001339 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 266940001340 PAS fold; Region: PAS; pfam00989 266940001341 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266940001342 putative active site [active] 266940001343 heme pocket [chemical binding]; other site 266940001344 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266940001345 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266940001346 dimer interface [polypeptide binding]; other site 266940001347 phosphorylation site [posttranslational modification] 266940001348 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266940001349 ATP binding site [chemical binding]; other site 266940001350 Mg2+ binding site [ion binding]; other site 266940001351 G-X-G motif; other site 266940001352 CHASE3 domain; Region: CHASE3; cl05000 266940001353 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266940001354 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266940001355 dimer interface [polypeptide binding]; other site 266940001356 phosphorylation site [posttranslational modification] 266940001357 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266940001358 ATP binding site [chemical binding]; other site 266940001359 Mg2+ binding site [ion binding]; other site 266940001360 G-X-G motif; other site 266940001361 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 266940001362 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 266940001363 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 266940001364 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 266940001365 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 266940001366 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 266940001367 flagellar motor switch protein FliN; Region: fliN; TIGR02480 266940001368 Flagellar motor switch protein FliM; Region: FliM; pfam02154 266940001369 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 266940001370 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 266940001371 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 266940001372 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 266940001373 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266940001374 ligand binding site [chemical binding]; other site 266940001375 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 266940001376 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 266940001377 Flagellar protein (FlbD); Region: FlbD; pfam06289 266940001378 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 266940001379 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 266940001380 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 266940001381 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 266940001382 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 266940001383 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 266940001384 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 266940001385 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 266940001386 NlpC/P60 family; Region: NLPC_P60; pfam00877 266940001387 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 266940001388 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266940001389 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266940001390 catalytic residue [active] 266940001391 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 266940001392 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 266940001393 Walker A motif/ATP binding site; other site 266940001394 Walker B motif; other site 266940001395 Flagellar assembly protein FliH; Region: FliH; pfam02108 266940001396 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 266940001397 FliG C-terminal domain; Region: FliG_C; pfam01706 266940001398 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 266940001399 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 266940001400 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 266940001401 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 266940001402 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 266940001403 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 266940001404 flagellar basal-body rod protein FlgB; Region: FlgB; TIGR01396 266940001405 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 266940001406 Penicillinase repressor; Region: Pencillinase_R; pfam03965 266940001407 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 266940001408 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 266940001409 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 266940001410 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 266940001411 Walker A/P-loop; other site 266940001412 ATP binding site [chemical binding]; other site 266940001413 ABC transporter; Region: ABC_tran; pfam00005 266940001414 Q-loop/lid; other site 266940001415 ABC transporter signature motif; other site 266940001416 Walker B; other site 266940001417 D-loop; other site 266940001418 H-loop/switch region; other site 266940001419 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940001420 Walker A/P-loop; other site 266940001421 ATP binding site [chemical binding]; other site 266940001422 Q-loop/lid; other site 266940001423 ABC transporter signature motif; other site 266940001424 Walker B; other site 266940001425 D-loop; other site 266940001426 H-loop/switch region; other site 266940001427 ethanolamine permease; Region: 2A0305; TIGR00908 266940001428 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 266940001429 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 266940001430 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 266940001431 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 266940001432 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 266940001433 catalytic triad [active] 266940001434 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 266940001435 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266940001436 NAD(P) binding site [chemical binding]; other site 266940001437 catalytic residues [active] 266940001438 short chain dehydrogenase; Provisional; Region: PRK06057 266940001439 classical (c) SDRs; Region: SDR_c; cd05233 266940001440 NAD(P) binding site [chemical binding]; other site 266940001441 active site 266940001442 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266940001443 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266940001444 DNA-binding site [nucleotide binding]; DNA binding site 266940001445 FCD domain; Region: FCD; pfam07729 266940001446 PAS fold; Region: PAS; pfam00989 266940001447 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266940001448 putative active site [active] 266940001449 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 266940001450 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 266940001451 putative active site [active] 266940001452 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266940001453 active site 266940001454 Flagellar protein FliS; Region: FliS; cl00654 266940001455 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 266940001456 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 266940001457 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 266940001458 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 266940001459 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 266940001460 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 266940001461 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 266940001462 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266940001463 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 266940001464 FlgN protein; Region: FlgN; pfam05130 266940001465 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 266940001466 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 266940001467 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 266940001468 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 266940001469 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 266940001470 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 266940001471 FliW protein; Region: FliW; pfam02623 266940001472 FliW protein; Region: FliW; pfam02623 266940001473 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 266940001474 substrate binding site [chemical binding]; other site 266940001475 PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939 266940001476 putative deacylase active site [active] 266940001477 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 266940001478 hydrophobic ligand binding site; other site 266940001479 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 266940001480 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 266940001481 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 266940001482 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 266940001483 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 266940001484 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266940001485 dimer interface [polypeptide binding]; other site 266940001486 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 266940001487 putative CheW interface [polypeptide binding]; other site 266940001488 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940001489 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940001490 metal binding site [ion binding]; metal-binding site 266940001491 active site 266940001492 I-site; other site 266940001493 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266940001494 Uncharacterized conserved protein [Function unknown]; Region: COG3391 266940001495 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 266940001496 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 266940001497 Interdomain contacts; other site 266940001498 Cytokine receptor motif; other site 266940001499 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940001500 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940001501 metal binding site [ion binding]; metal-binding site 266940001502 active site 266940001503 I-site; other site 266940001504 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 266940001505 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 266940001506 G1 box; other site 266940001507 GTP/Mg2+ binding site [chemical binding]; other site 266940001508 G2 box; other site 266940001509 Switch I region; other site 266940001510 G3 box; other site 266940001511 Switch II region; other site 266940001512 G5 box; other site 266940001513 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 266940001514 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 266940001515 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 266940001516 selenocysteine synthase; Provisional; Region: PRK04311 266940001517 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266940001518 selenium donor protein; Region: selD; TIGR00476 266940001519 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 266940001520 dimerization interface [polypeptide binding]; other site 266940001521 putative ATP binding site [chemical binding]; other site 266940001522 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 266940001523 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266940001524 dimerization interface [polypeptide binding]; other site 266940001525 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 266940001526 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266940001527 dimer interface [polypeptide binding]; other site 266940001528 putative CheW interface [polypeptide binding]; other site 266940001529 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 266940001530 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 266940001531 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 266940001532 4Fe-4S binding domain; Region: Fer4_6; pfam12837 266940001533 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 266940001534 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 266940001535 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 266940001536 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 266940001537 molybdopterin cofactor binding site; other site 266940001538 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 266940001539 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266940001540 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266940001541 active site 266940001542 catalytic tetrad [active] 266940001543 Asp23 family; Region: Asp23; pfam03780 266940001544 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 266940001545 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266940001546 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266940001547 DNA binding residues [nucleotide binding] 266940001548 Asp23 family; Region: Asp23; pfam03780 266940001549 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266940001550 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266940001551 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 266940001552 SelR domain; Region: SelR; pfam01641 266940001553 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 266940001554 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 266940001555 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266940001556 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 266940001557 substrate binding site [chemical binding]; other site 266940001558 active site 266940001559 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 266940001560 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266940001561 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266940001562 phosphorylation site [posttranslational modification] 266940001563 intermolecular recognition site; other site 266940001564 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266940001565 DNA binding residues [nucleotide binding] 266940001566 dimerization interface [polypeptide binding]; other site 266940001567 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 266940001568 catalytic site [active] 266940001569 putative active site [active] 266940001570 putative substrate binding site [chemical binding]; other site 266940001571 HRDC domain; Region: HRDC; pfam00570 266940001572 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 266940001573 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 266940001574 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 266940001575 active site residue [active] 266940001576 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 266940001577 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 266940001578 TPP-binding site; other site 266940001579 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 266940001580 PYR/PP interface [polypeptide binding]; other site 266940001581 dimer interface [polypeptide binding]; other site 266940001582 TPP binding site [chemical binding]; other site 266940001583 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266940001584 active site 266940001585 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 266940001586 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 266940001587 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 266940001588 Predicted flavoprotein [General function prediction only]; Region: COG0431 266940001589 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 266940001590 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 266940001591 ATP binding site [chemical binding]; other site 266940001592 Mg2+ binding site [ion binding]; other site 266940001593 G-X-G motif; other site 266940001594 HDOD domain; Region: HDOD; pfam08668 266940001595 PAS domain; Region: PAS_9; pfam13426 266940001596 PAS domain S-box; Region: sensory_box; TIGR00229 266940001597 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266940001598 putative active site [active] 266940001599 heme pocket [chemical binding]; other site 266940001600 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940001601 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940001602 metal binding site [ion binding]; metal-binding site 266940001603 active site 266940001604 I-site; other site 266940001605 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266940001606 aconitate hydratase; Validated; Region: PRK09277 266940001607 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 266940001608 substrate binding site [chemical binding]; other site 266940001609 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 266940001610 ligand binding site [chemical binding]; other site 266940001611 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 266940001612 substrate binding site [chemical binding]; other site 266940001613 TRAM domain; Region: TRAM; pfam01938 266940001614 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 266940001615 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266940001616 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 266940001617 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 266940001618 TrkA-N domain; Region: TrkA_N; pfam02254 266940001619 TrkA-C domain; Region: TrkA_C; pfam02080 266940001620 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 266940001621 TrkA-N domain; Region: TrkA_N; pfam02254 266940001622 TrkA-C domain; Region: TrkA_C; pfam02080 266940001623 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 266940001624 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 266940001625 ssDNA binding site; other site 266940001626 generic binding surface II; other site 266940001627 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 266940001628 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 266940001629 trimer interface [polypeptide binding]; other site 266940001630 active site 266940001631 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 266940001632 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 266940001633 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 266940001634 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 266940001635 active site 266940001636 dimerization interface [polypeptide binding]; other site 266940001637 ferrochelatase; Reviewed; Region: hemH; PRK00035 266940001638 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 266940001639 C-terminal domain interface [polypeptide binding]; other site 266940001640 active site 266940001641 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 266940001642 active site 266940001643 N-terminal domain interface [polypeptide binding]; other site 266940001644 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 266940001645 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 266940001646 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 266940001647 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266940001648 Coenzyme A binding pocket [chemical binding]; other site 266940001649 CoA binding domain; Region: CoA_binding_2; pfam13380 266940001650 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 266940001651 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 266940001652 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 266940001653 FMN binding site [chemical binding]; other site 266940001654 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 266940001655 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 266940001656 CAP-like domain; other site 266940001657 active site 266940001658 primary dimer interface [polypeptide binding]; other site 266940001659 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266940001660 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266940001661 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 266940001662 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 266940001663 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 266940001664 amidohydrolase; Region: amidohydrolases; TIGR01891 266940001665 metal binding site [ion binding]; metal-binding site 266940001666 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 266940001667 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 266940001668 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 266940001669 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 266940001670 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 266940001671 Carboxylesterase family; Region: COesterase; pfam00135 266940001672 substrate binding pocket [chemical binding]; other site 266940001673 catalytic triad [active] 266940001674 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 266940001675 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 266940001676 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 266940001677 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 266940001678 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 266940001679 dimerization domain swap beta strand [polypeptide binding]; other site 266940001680 regulatory protein interface [polypeptide binding]; other site 266940001681 active site 266940001682 regulatory phosphorylation site [posttranslational modification]; other site 266940001683 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 266940001684 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 266940001685 putative substrate binding site [chemical binding]; other site 266940001686 putative ATP binding site [chemical binding]; other site 266940001687 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 266940001688 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 266940001689 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 266940001690 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 266940001691 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266940001692 ATP binding site [chemical binding]; other site 266940001693 Mg2+ binding site [ion binding]; other site 266940001694 G-X-G motif; other site 266940001695 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 266940001696 anchoring element; other site 266940001697 dimer interface [polypeptide binding]; other site 266940001698 ATP binding site [chemical binding]; other site 266940001699 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 266940001700 active site 266940001701 metal binding site [ion binding]; metal-binding site 266940001702 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 266940001703 Protein of unknown function (DUF456); Region: DUF456; pfam04306 266940001704 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 266940001705 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 266940001706 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266940001707 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 266940001708 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266940001709 DNA binding residues [nucleotide binding] 266940001710 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266940001711 Ligand Binding Site [chemical binding]; other site 266940001712 EcsC protein family; Region: EcsC; pfam12787 266940001713 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266940001714 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 266940001715 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 266940001716 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 266940001717 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 266940001718 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 266940001719 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940001720 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266940001721 putative substrate translocation pore; other site 266940001722 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266940001723 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266940001724 DNA-binding site [nucleotide binding]; DNA binding site 266940001725 FCD domain; Region: FCD; pfam07729 266940001726 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 266940001727 Fe-S cluster binding site [ion binding]; other site 266940001728 active site 266940001729 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266940001730 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 266940001731 substrate binding site [chemical binding]; other site 266940001732 ATP binding site [chemical binding]; other site 266940001733 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266940001734 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266940001735 active site 266940001736 catalytic tetrad [active] 266940001737 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 266940001738 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266940001739 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940001740 Walker A/P-loop; other site 266940001741 ATP binding site [chemical binding]; other site 266940001742 ABC transporter; Region: ABC_tran; pfam00005 266940001743 Q-loop/lid; other site 266940001744 ABC transporter signature motif; other site 266940001745 Walker B; other site 266940001746 D-loop; other site 266940001747 H-loop/switch region; other site 266940001748 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266940001749 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940001750 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 266940001751 Walker A/P-loop; other site 266940001752 ATP binding site [chemical binding]; other site 266940001753 Q-loop/lid; other site 266940001754 ABC transporter signature motif; other site 266940001755 Walker B; other site 266940001756 D-loop; other site 266940001757 H-loop/switch region; other site 266940001758 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 266940001759 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 266940001760 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 266940001761 active site 266940001762 metal binding site [ion binding]; metal-binding site 266940001763 homotetramer interface [polypeptide binding]; other site 266940001764 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 266940001765 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 266940001766 ligand binding site [chemical binding]; other site 266940001767 NAD binding site [chemical binding]; other site 266940001768 tetramer interface [polypeptide binding]; other site 266940001769 catalytic site [active] 266940001770 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 266940001771 L-serine binding site [chemical binding]; other site 266940001772 ACT domain interface; other site 266940001773 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940001774 NADH(P)-binding; Region: NAD_binding_10; pfam13460 266940001775 NAD(P) binding site [chemical binding]; other site 266940001776 active site 266940001777 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 266940001778 PAC2 family; Region: PAC2; pfam09754 266940001779 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 266940001780 ATP cone domain; Region: ATP-cone; pfam03477 266940001781 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 266940001782 LexA repressor; Validated; Region: PRK00215 266940001783 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 266940001784 Catalytic site [active] 266940001785 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 266940001786 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 266940001787 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 266940001788 GTPases [General function prediction only]; Region: HflX; COG2262 266940001789 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 266940001790 HflX GTPase family; Region: HflX; cd01878 266940001791 G1 box; other site 266940001792 GTP/Mg2+ binding site [chemical binding]; other site 266940001793 Switch I region; other site 266940001794 G2 box; other site 266940001795 G3 box; other site 266940001796 Switch II region; other site 266940001797 G4 box; other site 266940001798 G5 box; other site 266940001799 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266940001800 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 266940001801 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 266940001802 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 266940001803 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 266940001804 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 266940001805 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 266940001806 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 266940001807 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266940001808 FeS/SAM binding site; other site 266940001809 TRAM domain; Region: TRAM; cl01282 266940001810 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 266940001811 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 266940001812 Walker A/P-loop; other site 266940001813 ATP binding site [chemical binding]; other site 266940001814 Q-loop/lid; other site 266940001815 ABC transporter signature motif; other site 266940001816 Walker B; other site 266940001817 D-loop; other site 266940001818 H-loop/switch region; other site 266940001819 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266940001820 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266940001821 substrate binding pocket [chemical binding]; other site 266940001822 membrane-bound complex binding site; other site 266940001823 hinge residues; other site 266940001824 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266940001825 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940001826 dimer interface [polypeptide binding]; other site 266940001827 conserved gate region; other site 266940001828 putative PBP binding loops; other site 266940001829 ABC-ATPase subunit interface; other site 266940001830 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940001831 dimer interface [polypeptide binding]; other site 266940001832 conserved gate region; other site 266940001833 putative PBP binding loops; other site 266940001834 ABC-ATPase subunit interface; other site 266940001835 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 266940001836 recombination regulator RecX; Reviewed; Region: recX; PRK00117 266940001837 recombinase A; Provisional; Region: recA; PRK09354 266940001838 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 266940001839 hexamer interface [polypeptide binding]; other site 266940001840 Walker A motif; other site 266940001841 ATP binding site [chemical binding]; other site 266940001842 Walker B motif; other site 266940001843 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 266940001844 Strictosidine synthase; Region: Str_synth; pfam03088 266940001845 Protein of unknown function (DUF664); Region: DUF664; pfam04978 266940001846 DinB superfamily; Region: DinB_2; pfam12867 266940001847 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266940001848 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 266940001849 ATP binding site [chemical binding]; other site 266940001850 putative Mg++ binding site [ion binding]; other site 266940001851 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266940001852 nucleotide binding region [chemical binding]; other site 266940001853 ATP-binding site [chemical binding]; other site 266940001854 DEAD/H associated; Region: DEAD_assoc; pfam08494 266940001855 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 266940001856 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 266940001857 putative DNA binding site [nucleotide binding]; other site 266940001858 catalytic residue [active] 266940001859 putative H2TH interface [polypeptide binding]; other site 266940001860 putative catalytic residues [active] 266940001861 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 266940001862 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266940001863 non-specific DNA binding site [nucleotide binding]; other site 266940001864 salt bridge; other site 266940001865 sequence-specific DNA binding site [nucleotide binding]; other site 266940001866 Competence-damaged protein; Region: CinA; pfam02464 266940001867 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 266940001868 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 266940001869 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 266940001870 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266940001871 FeS/SAM binding site; other site 266940001872 LabA_like proteins; Region: LabA_like; cd06167 266940001873 putative metal binding site [ion binding]; other site 266940001874 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 266940001875 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 266940001876 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 266940001877 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 266940001878 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266940001879 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 266940001880 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 266940001881 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 266940001882 dimer interface [polypeptide binding]; other site 266940001883 active site 266940001884 catalytic residue [active] 266940001885 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 266940001886 putative phosphatase; Provisional; Region: PRK11587 266940001887 motif I; other site 266940001888 active site 266940001889 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 266940001890 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 266940001891 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 266940001892 active site 266940001893 Fe binding site [ion binding]; other site 266940001894 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 266940001895 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266940001896 putative NAD(P) binding site [chemical binding]; other site 266940001897 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 266940001898 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 266940001899 NAD binding site [chemical binding]; other site 266940001900 catalytic Zn binding site [ion binding]; other site 266940001901 structural Zn binding site [ion binding]; other site 266940001902 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 266940001903 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266940001904 motif II; other site 266940001905 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 266940001906 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 266940001907 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 266940001908 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 266940001909 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266940001910 S-adenosylmethionine binding site [chemical binding]; other site 266940001911 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 266940001912 active site 266940001913 dihydrodipicolinate reductase; Provisional; Region: PRK00048 266940001914 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 266940001915 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 266940001916 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 266940001917 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 266940001918 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 266940001919 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 266940001920 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 266940001921 oligomer interface [polypeptide binding]; other site 266940001922 RNA binding site [nucleotide binding]; other site 266940001923 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 266940001924 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 266940001925 RNase E interface [polypeptide binding]; other site 266940001926 trimer interface [polypeptide binding]; other site 266940001927 active site 266940001928 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 266940001929 putative nucleic acid binding region [nucleotide binding]; other site 266940001930 G-X-X-G motif; other site 266940001931 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 266940001932 RNA binding site [nucleotide binding]; other site 266940001933 domain interface; other site 266940001934 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 266940001935 16S/18S rRNA binding site [nucleotide binding]; other site 266940001936 S13e-L30e interaction site [polypeptide binding]; other site 266940001937 25S rRNA binding site [nucleotide binding]; other site 266940001938 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 266940001939 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 266940001940 active site 266940001941 Riboflavin kinase; Region: Flavokinase; pfam01687 266940001942 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 266940001943 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 266940001944 active site 266940001945 dimer interface [polypeptide binding]; other site 266940001946 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 266940001947 dimer interface [polypeptide binding]; other site 266940001948 active site 266940001949 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 266940001950 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 266940001951 short chain dehydrogenase; Provisional; Region: PRK06841 266940001952 classical (c) SDRs; Region: SDR_c; cd05233 266940001953 NAD(P) binding site [chemical binding]; other site 266940001954 active site 266940001955 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266940001956 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266940001957 Walker A/P-loop; other site 266940001958 ATP binding site [chemical binding]; other site 266940001959 Q-loop/lid; other site 266940001960 ABC transporter signature motif; other site 266940001961 Walker B; other site 266940001962 D-loop; other site 266940001963 H-loop/switch region; other site 266940001964 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266940001965 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266940001966 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266940001967 TM-ABC transporter signature motif; other site 266940001968 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 266940001969 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266940001970 putative ligand binding site [chemical binding]; other site 266940001971 classical (c) SDRs; Region: SDR_c; cd05233 266940001972 NAD(P) binding site [chemical binding]; other site 266940001973 active site 266940001974 L-idonate 5-dehydrogenase; Region: PLN02702 266940001975 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 266940001976 inhibitor binding site; inhibition site 266940001977 catalytic Zn binding site [ion binding]; other site 266940001978 structural Zn binding site [ion binding]; other site 266940001979 NADP binding site [chemical binding]; other site 266940001980 tetramer interface [polypeptide binding]; other site 266940001981 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940001982 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266940001983 NAD(P) binding site [chemical binding]; other site 266940001984 active site 266940001985 Repair protein; Region: Repair_PSII; pfam04536 266940001986 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 266940001987 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 266940001988 TPP-binding site; other site 266940001989 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 266940001990 PYR/PP interface [polypeptide binding]; other site 266940001991 dimer interface [polypeptide binding]; other site 266940001992 TPP binding site [chemical binding]; other site 266940001993 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 266940001994 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 266940001995 Acyltransferase family; Region: Acyl_transf_3; pfam01757 266940001996 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 266940001997 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 266940001998 RNA binding site [nucleotide binding]; other site 266940001999 active site 266940002000 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 266940002001 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266940002002 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266940002003 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266940002004 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940002005 putative substrate translocation pore; other site 266940002006 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 266940002007 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 266940002008 Protein of unknown function (DUF503); Region: DUF503; pfam04456 266940002009 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 266940002010 translation initiation factor IF-2; Region: IF-2; TIGR00487 266940002011 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 266940002012 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 266940002013 G1 box; other site 266940002014 putative GEF interaction site [polypeptide binding]; other site 266940002015 GTP/Mg2+ binding site [chemical binding]; other site 266940002016 Switch I region; other site 266940002017 G2 box; other site 266940002018 G3 box; other site 266940002019 Switch II region; other site 266940002020 G4 box; other site 266940002021 G5 box; other site 266940002022 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 266940002023 Translation-initiation factor 2; Region: IF-2; pfam11987 266940002024 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 266940002025 Protein of unknown function (DUF448); Region: DUF448; pfam04296 266940002026 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 266940002027 NusA N-terminal domain; Region: NusA_N; pfam08529 266940002028 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 266940002029 RNA binding site [nucleotide binding]; other site 266940002030 homodimer interface [polypeptide binding]; other site 266940002031 NusA-like KH domain; Region: KH_5; pfam13184 266940002032 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 266940002033 G-X-X-G motif; other site 266940002034 Sm and related proteins; Region: Sm_like; cl00259 266940002035 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 266940002036 putative catalytic site [active] 266940002037 putative metal binding site [ion binding]; other site 266940002038 putative phosphate binding site [ion binding]; other site 266940002039 prolyl-tRNA synthetase; Provisional; Region: PRK09194 266940002040 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 266940002041 dimer interface [polypeptide binding]; other site 266940002042 motif 1; other site 266940002043 active site 266940002044 motif 2; other site 266940002045 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 266940002046 putative deacylase active site [active] 266940002047 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 266940002048 active site 266940002049 motif 3; other site 266940002050 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 266940002051 anticodon binding site; other site 266940002052 Predicted amidohydrolase [General function prediction only]; Region: COG0388 266940002053 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 266940002054 active site 266940002055 catalytic triad [active] 266940002056 dimer interface [polypeptide binding]; other site 266940002057 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266940002058 sequence-specific DNA binding site [nucleotide binding]; other site 266940002059 salt bridge; other site 266940002060 Cupin domain; Region: Cupin_2; pfam07883 266940002061 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 266940002062 agmatinase; Region: agmatinase; TIGR01230 266940002063 oligomer interface [polypeptide binding]; other site 266940002064 putative active site [active] 266940002065 Mn binding site [ion binding]; other site 266940002066 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266940002067 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 266940002068 H+ Antiporter protein; Region: 2A0121; TIGR00900 266940002069 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 266940002070 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 266940002071 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 266940002072 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 266940002073 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 266940002074 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 266940002075 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 266940002076 active site 266940002077 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 266940002078 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 266940002079 putative substrate binding region [chemical binding]; other site 266940002080 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 266940002081 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 266940002082 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 266940002083 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 266940002084 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 266940002085 succinic semialdehyde dehydrogenase; Region: PLN02278 266940002086 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 266940002087 tetramerization interface [polypeptide binding]; other site 266940002088 NAD(P) binding site [chemical binding]; other site 266940002089 catalytic residues [active] 266940002090 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 266940002091 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266940002092 inhibitor-cofactor binding pocket; inhibition site 266940002093 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266940002094 catalytic residue [active] 266940002095 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 266940002096 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 266940002097 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 266940002098 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 266940002099 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 266940002100 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266940002101 FeS/SAM binding site; other site 266940002102 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 266940002103 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 266940002104 ribosome recycling factor; Reviewed; Region: frr; PRK00083 266940002105 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 266940002106 hinge region; other site 266940002107 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 266940002108 putative nucleotide binding site [chemical binding]; other site 266940002109 uridine monophosphate binding site [chemical binding]; other site 266940002110 homohexameric interface [polypeptide binding]; other site 266940002111 elongation factor Ts; Provisional; Region: tsf; PRK09377 266940002112 UBA/TS-N domain; Region: UBA; pfam00627 266940002113 Elongation factor TS; Region: EF_TS; pfam00889 266940002114 Elongation factor TS; Region: EF_TS; pfam00889 266940002115 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 266940002116 rRNA interaction site [nucleotide binding]; other site 266940002117 S8 interaction site; other site 266940002118 putative laminin-1 binding site; other site 266940002119 aminotransferase; Validated; Region: PRK07777 266940002120 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266940002121 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266940002122 homodimer interface [polypeptide binding]; other site 266940002123 catalytic residue [active] 266940002124 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 266940002125 Peptidase family M23; Region: Peptidase_M23; pfam01551 266940002126 RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288 266940002127 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266940002128 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 266940002129 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266940002130 DNA binding residues [nucleotide binding] 266940002131 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 266940002132 hypothetical protein; Reviewed; Region: PRK09588 266940002133 DNA protecting protein DprA; Region: dprA; TIGR00732 266940002134 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 266940002135 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 266940002136 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 266940002137 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 266940002138 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 266940002139 hypothetical protein; Reviewed; Region: PRK12497 266940002140 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 266940002141 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 266940002142 RNA/DNA hybrid binding site [nucleotide binding]; other site 266940002143 active site 266940002144 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 266940002145 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 266940002146 Catalytic site [active] 266940002147 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 266940002148 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 266940002149 Catalytic site [active] 266940002150 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 266940002151 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 266940002152 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 266940002153 RimM N-terminal domain; Region: RimM; pfam01782 266940002154 PRC-barrel domain; Region: PRC; pfam05239 266940002155 hypothetical protein; Provisional; Region: PRK02821 266940002156 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 266940002157 G-X-X-G motif; other site 266940002158 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 266940002159 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266940002160 Amidohydrolase; Region: Amidohydro_4; pfam13147 266940002161 active site 266940002162 signal recognition particle protein; Provisional; Region: PRK10867 266940002163 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 266940002164 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 266940002165 P loop; other site 266940002166 GTP binding site [chemical binding]; other site 266940002167 Signal peptide binding domain; Region: SRP_SPB; pfam02978 266940002168 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 266940002169 PII uridylyl-transferase; Provisional; Region: PRK03381 266940002170 metal binding triad; other site 266940002171 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 266940002172 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 266940002173 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 266940002174 Nitrogen regulatory protein P-II; Region: P-II; smart00938 266940002175 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 266940002176 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 266940002177 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 266940002178 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 266940002179 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 266940002180 AAA domain; Region: AAA_23; pfam13476 266940002181 Walker A/P-loop; other site 266940002182 ATP binding site [chemical binding]; other site 266940002183 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 266940002184 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 266940002185 ABC transporter signature motif; other site 266940002186 Walker B; other site 266940002187 D-loop; other site 266940002188 H-loop/switch region; other site 266940002189 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 266940002190 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940002191 putative substrate translocation pore; other site 266940002192 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 266940002193 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 266940002194 short chain dehydrogenase; Validated; Region: PRK08324 266940002195 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 266940002196 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 266940002197 putative NAD(P) binding site [chemical binding]; other site 266940002198 active site 266940002199 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 266940002200 N- and C-terminal domain interface [polypeptide binding]; other site 266940002201 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 266940002202 active site 266940002203 putative catalytic site [active] 266940002204 metal binding site [ion binding]; metal-binding site 266940002205 ATP binding site [chemical binding]; other site 266940002206 carbohydrate binding site [chemical binding]; other site 266940002207 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 266940002208 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 266940002209 active site 266940002210 substrate binding site [chemical binding]; other site 266940002211 FMN binding site [chemical binding]; other site 266940002212 putative catalytic residues [active] 266940002213 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 266940002214 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 266940002215 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 266940002216 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 266940002217 non-specific DNA interactions [nucleotide binding]; other site 266940002218 DNA binding site [nucleotide binding] 266940002219 sequence specific DNA binding site [nucleotide binding]; other site 266940002220 putative cAMP binding site [chemical binding]; other site 266940002221 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 266940002222 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 266940002223 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266940002224 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266940002225 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940002226 dimer interface [polypeptide binding]; other site 266940002227 conserved gate region; other site 266940002228 putative PBP binding loops; other site 266940002229 ABC-ATPase subunit interface; other site 266940002230 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266940002231 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940002232 dimer interface [polypeptide binding]; other site 266940002233 conserved gate region; other site 266940002234 putative PBP binding loops; other site 266940002235 ABC-ATPase subunit interface; other site 266940002236 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 266940002237 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 266940002238 DNA binding site [nucleotide binding] 266940002239 catalytic residue [active] 266940002240 H2TH interface [polypeptide binding]; other site 266940002241 putative catalytic residues [active] 266940002242 turnover-facilitating residue; other site 266940002243 intercalation triad [nucleotide binding]; other site 266940002244 8OG recognition residue [nucleotide binding]; other site 266940002245 putative reading head residues; other site 266940002246 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 266940002247 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 266940002248 ribonuclease III; Reviewed; Region: rnc; PRK00102 266940002249 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 266940002250 dimerization interface [polypeptide binding]; other site 266940002251 active site 266940002252 metal binding site [ion binding]; metal-binding site 266940002253 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 266940002254 dsRNA binding site [nucleotide binding]; other site 266940002255 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 266940002256 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 266940002257 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 266940002258 active site 266940002259 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK13964 266940002260 (T/H)XGH motif; other site 266940002261 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266940002262 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 266940002263 thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277 266940002264 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940002265 Walker A/P-loop; other site 266940002266 ATP binding site [chemical binding]; other site 266940002267 Q-loop/lid; other site 266940002268 ABC transporter signature motif; other site 266940002269 Walker B; other site 266940002270 D-loop; other site 266940002271 H-loop/switch region; other site 266940002272 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 266940002273 generic binding surface II; other site 266940002274 ssDNA binding site; other site 266940002275 DEAD-like helicases superfamily; Region: DEXDc; smart00487 266940002276 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266940002277 ATP binding site [chemical binding]; other site 266940002278 putative Mg++ binding site [ion binding]; other site 266940002279 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266940002280 nucleotide binding region [chemical binding]; other site 266940002281 ATP-binding site [chemical binding]; other site 266940002282 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 266940002283 thiamine monophosphate kinase; Provisional; Region: PRK05731 266940002284 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 266940002285 ATP binding site [chemical binding]; other site 266940002286 dimerization interface [polypeptide binding]; other site 266940002287 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 266940002288 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 266940002289 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 266940002290 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 266940002291 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 266940002292 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266940002293 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266940002294 catalytic residue [active] 266940002295 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266940002296 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266940002297 non-specific DNA binding site [nucleotide binding]; other site 266940002298 salt bridge; other site 266940002299 sequence-specific DNA binding site [nucleotide binding]; other site 266940002300 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 266940002301 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 266940002302 hinge; other site 266940002303 active site 266940002304 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 266940002305 IHF - DNA interface [nucleotide binding]; other site 266940002306 IHF dimer interface [polypeptide binding]; other site 266940002307 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 266940002308 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 266940002309 substrate binding site [chemical binding]; other site 266940002310 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 266940002311 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 266940002312 substrate binding site [chemical binding]; other site 266940002313 ligand binding site [chemical binding]; other site 266940002314 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 266940002315 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 266940002316 Bacterial transcriptional regulator; Region: IclR; pfam01614 266940002317 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 266940002318 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266940002319 active site 266940002320 HIGH motif; other site 266940002321 nucleotide binding site [chemical binding]; other site 266940002322 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 266940002323 active site 266940002324 KMSKS motif; other site 266940002325 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 266940002326 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 266940002327 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266940002328 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 266940002329 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 266940002330 homodimer interface [polypeptide binding]; other site 266940002331 substrate-cofactor binding pocket; other site 266940002332 catalytic residue [active] 266940002333 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 266940002334 tartrate dehydrogenase; Region: TTC; TIGR02089 266940002335 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 266940002336 Histidine kinase; Region: HisKA_3; pfam07730 266940002337 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266940002338 ATP binding site [chemical binding]; other site 266940002339 Mg2+ binding site [ion binding]; other site 266940002340 G-X-G motif; other site 266940002341 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266940002342 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266940002343 active site 266940002344 phosphorylation site [posttranslational modification] 266940002345 intermolecular recognition site; other site 266940002346 dimerization interface [polypeptide binding]; other site 266940002347 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266940002348 DNA binding residues [nucleotide binding] 266940002349 dimerization interface [polypeptide binding]; other site 266940002350 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 266940002351 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 266940002352 Walker A/P-loop; other site 266940002353 ATP binding site [chemical binding]; other site 266940002354 Q-loop/lid; other site 266940002355 ABC transporter signature motif; other site 266940002356 Walker B; other site 266940002357 D-loop; other site 266940002358 H-loop/switch region; other site 266940002359 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 266940002360 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 266940002361 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 266940002362 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 266940002363 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 266940002364 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266940002365 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266940002366 catalytic residue [active] 266940002367 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 266940002368 Protein of unknown function (DUF3253); Region: DUF3253; pfam11625 266940002369 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 266940002370 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 266940002371 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 266940002372 putative dimer interface [polypeptide binding]; other site 266940002373 putative [2Fe-2S] cluster binding site [ion binding]; other site 266940002374 Cupin-like domain; Region: Cupin_8; pfam13621 266940002375 ketol-acid reductoisomerase; Provisional; Region: PRK05479 266940002376 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 266940002377 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 266940002378 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 266940002379 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 266940002380 putative valine binding site [chemical binding]; other site 266940002381 dimer interface [polypeptide binding]; other site 266940002382 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 266940002383 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 266940002384 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266940002385 PYR/PP interface [polypeptide binding]; other site 266940002386 dimer interface [polypeptide binding]; other site 266940002387 TPP binding site [chemical binding]; other site 266940002388 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266940002389 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 266940002390 TPP-binding site [chemical binding]; other site 266940002391 dimer interface [polypeptide binding]; other site 266940002392 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 266940002393 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266940002394 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266940002395 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266940002396 active site 266940002397 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266940002398 catalytic tetrad [active] 266940002399 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266940002400 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266940002401 DNA binding site [nucleotide binding] 266940002402 domain linker motif; other site 266940002403 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 266940002404 dimerization interface [polypeptide binding]; other site 266940002405 ligand binding site [chemical binding]; other site 266940002406 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 266940002407 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 266940002408 molybdopterin cofactor binding site; other site 266940002409 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 266940002410 molybdopterin cofactor binding site; other site 266940002411 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 266940002412 Flavodoxin; Region: Flavodoxin_1; pfam00258 266940002413 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 266940002414 FAD binding pocket [chemical binding]; other site 266940002415 conserved FAD binding motif [chemical binding]; other site 266940002416 phosphate binding motif [ion binding]; other site 266940002417 beta-alpha-beta structure motif; other site 266940002418 NAD binding pocket [chemical binding]; other site 266940002419 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 266940002420 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 266940002421 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266940002422 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 266940002423 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 266940002424 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 266940002425 iron-sulfur cluster [ion binding]; other site 266940002426 [2Fe-2S] cluster binding site [ion binding]; other site 266940002427 Putative NAD(P)-binding; Region: NAD_binding_7; cl17660 266940002428 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 266940002429 active site 266940002430 SAM binding site [chemical binding]; other site 266940002431 homodimer interface [polypeptide binding]; other site 266940002432 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 266940002433 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 266940002434 active site 266940002435 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 266940002436 DNA binding site [nucleotide binding] 266940002437 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 266940002438 putative active site [active] 266940002439 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 266940002440 active site 266940002441 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166 266940002442 putative ligand binding site [chemical binding]; other site 266940002443 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 266940002444 putative NAD binding site [chemical binding]; other site 266940002445 catalytic site [active] 266940002446 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 266940002447 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 266940002448 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 266940002449 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 266940002450 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 266940002451 GatB domain; Region: GatB_Yqey; smart00845 266940002452 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 266940002453 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 266940002454 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 266940002455 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 266940002456 Amidinotransferase; Region: Amidinotransf; pfam02274 266940002457 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 266940002458 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 266940002459 nucleotide binding pocket [chemical binding]; other site 266940002460 K-X-D-G motif; other site 266940002461 catalytic site [active] 266940002462 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 266940002463 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 266940002464 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 266940002465 Dimer interface [polypeptide binding]; other site 266940002466 BRCT sequence motif; other site 266940002467 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 266940002468 Protein of unknown function (DUF523); Region: DUF523; cl00733 266940002469 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 266940002470 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266940002471 Coenzyme A binding pocket [chemical binding]; other site 266940002472 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 266940002473 TAP-like protein; Region: Abhydrolase_4; pfam08386 266940002474 Protein of unknown function (DUF445); Region: DUF445; pfam04286 266940002475 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 266940002476 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 266940002477 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266940002478 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 266940002479 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266940002480 catalytic residue [active] 266940002481 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 266940002482 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 266940002483 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 266940002484 active site 266940002485 catalytic site [active] 266940002486 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940002487 dimer interface [polypeptide binding]; other site 266940002488 conserved gate region; other site 266940002489 putative PBP binding loops; other site 266940002490 ABC-ATPase subunit interface; other site 266940002491 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 266940002492 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266940002493 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266940002494 Walker A/P-loop; other site 266940002495 ATP binding site [chemical binding]; other site 266940002496 Q-loop/lid; other site 266940002497 ABC transporter signature motif; other site 266940002498 Walker B; other site 266940002499 D-loop; other site 266940002500 H-loop/switch region; other site 266940002501 NMT1/THI5 like; Region: NMT1; pfam09084 266940002502 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 266940002503 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 266940002504 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 266940002505 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266940002506 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266940002507 adenosine deaminase; Provisional; Region: PRK09358 266940002508 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 266940002509 active site 266940002510 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 266940002511 putative homodimer interface [polypeptide binding]; other site 266940002512 putative active site pocket [active] 266940002513 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 266940002514 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 266940002515 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 266940002516 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 266940002517 active site 266940002518 homodimer interface [polypeptide binding]; other site 266940002519 catalytic site [active] 266940002520 acceptor binding site [chemical binding]; other site 266940002521 trehalose synthase; Region: treS_nterm; TIGR02456 266940002522 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 266940002523 active site 266940002524 catalytic site [active] 266940002525 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 266940002526 glycogen branching enzyme; Provisional; Region: PRK05402 266940002527 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 266940002528 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 266940002529 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 266940002530 active site 266940002531 catalytic site [active] 266940002532 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 266940002533 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 266940002534 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940002535 ABC-ATPase subunit interface; other site 266940002536 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940002537 dimer interface [polypeptide binding]; other site 266940002538 conserved gate region; other site 266940002539 ABC-ATPase subunit interface; other site 266940002540 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 266940002541 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 266940002542 Walker A/P-loop; other site 266940002543 ATP binding site [chemical binding]; other site 266940002544 Q-loop/lid; other site 266940002545 ABC transporter signature motif; other site 266940002546 Walker B; other site 266940002547 D-loop; other site 266940002548 H-loop/switch region; other site 266940002549 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 266940002550 active sites [active] 266940002551 tetramer interface [polypeptide binding]; other site 266940002552 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 266940002553 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266940002554 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266940002555 DNA binding site [nucleotide binding] 266940002556 domain linker motif; other site 266940002557 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 266940002558 ligand binding site [chemical binding]; other site 266940002559 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 266940002560 active sites [active] 266940002561 tetramer interface [polypeptide binding]; other site 266940002562 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 266940002563 Beta-lactamase; Region: Beta-lactamase; pfam00144 266940002564 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 266940002565 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940002566 Walker A/P-loop; other site 266940002567 ATP binding site [chemical binding]; other site 266940002568 Q-loop/lid; other site 266940002569 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266940002570 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940002571 Walker A/P-loop; other site 266940002572 ATP binding site [chemical binding]; other site 266940002573 Q-loop/lid; other site 266940002574 ABC transporter signature motif; other site 266940002575 Walker B; other site 266940002576 D-loop; other site 266940002577 H-loop/switch region; other site 266940002578 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 266940002579 Domain of unknown function DUF77; Region: DUF77; pfam01910 266940002580 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 266940002581 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 266940002582 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266940002583 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266940002584 catalytic residue [active] 266940002585 hypothetical protein; Provisional; Region: PRK03298 266940002586 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 266940002587 anti sigma factor interaction site; other site 266940002588 regulatory phosphorylation site [posttranslational modification]; other site 266940002589 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 266940002590 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 266940002591 gamma subunit interface [polypeptide binding]; other site 266940002592 epsilon subunit interface [polypeptide binding]; other site 266940002593 LBP interface [polypeptide binding]; other site 266940002594 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 266940002595 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 266940002596 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 266940002597 alpha subunit interaction interface [polypeptide binding]; other site 266940002598 Walker A motif; other site 266940002599 ATP binding site [chemical binding]; other site 266940002600 Walker B motif; other site 266940002601 inhibitor binding site; inhibition site 266940002602 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 266940002603 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 266940002604 core domain interface [polypeptide binding]; other site 266940002605 delta subunit interface [polypeptide binding]; other site 266940002606 epsilon subunit interface [polypeptide binding]; other site 266940002607 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 266940002608 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 266940002609 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 266940002610 beta subunit interaction interface [polypeptide binding]; other site 266940002611 Walker A motif; other site 266940002612 ATP binding site [chemical binding]; other site 266940002613 Walker B motif; other site 266940002614 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 266940002615 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 266940002616 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 266940002617 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 266940002618 ATP synthase subunit C; Region: ATP-synt_C; cl00466 266940002619 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 266940002620 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 266940002621 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 266940002622 Mg++ binding site [ion binding]; other site 266940002623 putative catalytic motif [active] 266940002624 substrate binding site [chemical binding]; other site 266940002625 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 266940002626 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 266940002627 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266940002628 S-adenosylmethionine binding site [chemical binding]; other site 266940002629 Beta-lactamase; Region: Beta-lactamase; pfam00144 266940002630 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 266940002631 This domain is found in peptide chain release factors; Region: PCRF; smart00937 266940002632 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 266940002633 RF-1 domain; Region: RF-1; pfam00472 266940002634 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 266940002635 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 266940002636 transcription termination factor Rho; Provisional; Region: rho; PRK09376 266940002637 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 266940002638 RNA binding site [nucleotide binding]; other site 266940002639 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 266940002640 multimer interface [polypeptide binding]; other site 266940002641 Walker A motif; other site 266940002642 ATP binding site [chemical binding]; other site 266940002643 Walker B motif; other site 266940002644 homoserine kinase; Provisional; Region: PRK01212 266940002645 threonine synthase; Reviewed; Region: PRK06721 266940002646 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 266940002647 homodimer interface [polypeptide binding]; other site 266940002648 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266940002649 catalytic residue [active] 266940002650 homoserine dehydrogenase; Provisional; Region: PRK06349 266940002651 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 266940002652 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 266940002653 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 266940002654 diaminopimelate decarboxylase; Region: lysA; TIGR01048 266940002655 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 266940002656 active site 266940002657 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266940002658 substrate binding site [chemical binding]; other site 266940002659 catalytic residues [active] 266940002660 dimer interface [polypeptide binding]; other site 266940002661 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 266940002662 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 266940002663 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 266940002664 active site 266940002665 HIGH motif; other site 266940002666 KMSK motif region; other site 266940002667 DALR anticodon binding domain; Region: DALR_1; smart00836 266940002668 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 266940002669 SprT homologues; Region: SprT; cl01182 266940002670 SprT-like family; Region: SprT-like; pfam10263 266940002671 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 266940002672 catalytic residues [active] 266940002673 dimer interface [polypeptide binding]; other site 266940002674 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 266940002675 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 266940002676 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 266940002677 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266940002678 active site 266940002679 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 266940002680 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266940002681 ATP binding site [chemical binding]; other site 266940002682 putative Mg++ binding site [ion binding]; other site 266940002683 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 266940002684 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 266940002685 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 266940002686 DEAD-like helicases superfamily; Region: DEXDc; smart00487 266940002687 ATP binding site [chemical binding]; other site 266940002688 putative Mg++ binding site [ion binding]; other site 266940002689 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266940002690 nucleotide binding region [chemical binding]; other site 266940002691 ATP-binding site [chemical binding]; other site 266940002692 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 266940002693 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 266940002694 ABC-ATPase subunit interface; other site 266940002695 dimer interface [polypeptide binding]; other site 266940002696 putative PBP binding regions; other site 266940002697 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 266940002698 dimer interface [polypeptide binding]; other site 266940002699 putative PBP binding regions; other site 266940002700 ABC-ATPase subunit interface; other site 266940002701 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 266940002702 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 266940002703 Walker A/P-loop; other site 266940002704 ATP binding site [chemical binding]; other site 266940002705 Q-loop/lid; other site 266940002706 ABC transporter signature motif; other site 266940002707 Walker B; other site 266940002708 D-loop; other site 266940002709 H-loop/switch region; other site 266940002710 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 266940002711 ATP-NAD kinase; Region: NAD_kinase; pfam01513 266940002712 PRC-barrel domain; Region: PRC; pfam05239 266940002713 Domain of unknown function DUF21; Region: DUF21; pfam01595 266940002714 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 266940002715 FOG: CBS domain [General function prediction only]; Region: COG0517 266940002716 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 266940002717 Domain of unknown function DUF21; Region: DUF21; pfam01595 266940002718 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 266940002719 Transporter associated domain; Region: CorC_HlyC; smart01091 266940002720 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266940002721 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 266940002722 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 266940002723 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 266940002724 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 266940002725 active site 266940002726 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266940002727 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266940002728 active site 266940002729 phosphorylation site [posttranslational modification] 266940002730 intermolecular recognition site; other site 266940002731 dimerization interface [polypeptide binding]; other site 266940002732 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266940002733 DNA binding site [nucleotide binding] 266940002734 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266940002735 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266940002736 dimerization interface [polypeptide binding]; other site 266940002737 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266940002738 dimer interface [polypeptide binding]; other site 266940002739 phosphorylation site [posttranslational modification] 266940002740 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266940002741 ATP binding site [chemical binding]; other site 266940002742 Mg2+ binding site [ion binding]; other site 266940002743 G-X-G motif; other site 266940002744 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 266940002745 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 266940002746 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 266940002747 TPP-binding site [chemical binding]; other site 266940002748 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 266940002749 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835 266940002750 active site 266940002751 catalytic triad [active] 266940002752 oxyanion hole [active] 266940002753 Predicted ATPase [General function prediction only]; Region: COG3910 266940002754 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 266940002755 Walker A/P-loop; other site 266940002756 ATP binding site [chemical binding]; other site 266940002757 Q-loop/lid; other site 266940002758 ABC transporter signature motif; other site 266940002759 Walker B; other site 266940002760 D-loop; other site 266940002761 H-loop/switch region; other site 266940002762 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 266940002763 putative active site [active] 266940002764 putative metal binding site [ion binding]; other site 266940002765 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 266940002766 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266940002767 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266940002768 substrate binding pocket [chemical binding]; other site 266940002769 membrane-bound complex binding site; other site 266940002770 hinge residues; other site 266940002771 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940002772 dimer interface [polypeptide binding]; other site 266940002773 ABC-ATPase subunit interface; other site 266940002774 putative PBP binding loops; other site 266940002775 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 266940002776 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 266940002777 Walker A/P-loop; other site 266940002778 ATP binding site [chemical binding]; other site 266940002779 Q-loop/lid; other site 266940002780 ABC transporter signature motif; other site 266940002781 Walker B; other site 266940002782 D-loop; other site 266940002783 H-loop/switch region; other site 266940002784 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266940002785 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940002786 NAD(P) binding site [chemical binding]; other site 266940002787 active site 266940002788 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 266940002789 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 266940002790 FMN-binding pocket [chemical binding]; other site 266940002791 flavin binding motif; other site 266940002792 phosphate binding motif [ion binding]; other site 266940002793 beta-alpha-beta structure motif; other site 266940002794 NAD binding pocket [chemical binding]; other site 266940002795 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266940002796 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 266940002797 catalytic loop [active] 266940002798 iron binding site [ion binding]; other site 266940002799 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 266940002800 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 266940002801 MOSC domain; Region: MOSC; pfam03473 266940002802 Protein of unknown function (DUF664); Region: DUF664; pfam04978 266940002803 DinB superfamily; Region: DinB_2; pfam12867 266940002804 HAMP domain; Region: HAMP; pfam00672 266940002805 dimerization interface [polypeptide binding]; other site 266940002806 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 266940002807 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 266940002808 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 266940002809 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 266940002810 conserved cys residue [active] 266940002811 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266940002812 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 266940002813 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 266940002814 Walker A motif; other site 266940002815 ATP binding site [chemical binding]; other site 266940002816 Walker B motif; other site 266940002817 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 266940002818 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266940002819 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266940002820 DNA binding residues [nucleotide binding] 266940002821 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 266940002822 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 266940002823 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 266940002824 hinge; other site 266940002825 active site 266940002826 Predicted GTPases [General function prediction only]; Region: COG1162 266940002827 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 266940002828 GTPase/Zn-binding domain interface [polypeptide binding]; other site 266940002829 GTP/Mg2+ binding site [chemical binding]; other site 266940002830 G4 box; other site 266940002831 G5 box; other site 266940002832 G1 box; other site 266940002833 Switch I region; other site 266940002834 G2 box; other site 266940002835 G3 box; other site 266940002836 Switch II region; other site 266940002837 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 266940002838 putative active site [active] 266940002839 redox center [active] 266940002840 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 266940002841 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 266940002842 active site 266940002843 CAAX protease self-immunity; Region: Abi; pfam02517 266940002844 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266940002845 Ligand Binding Site [chemical binding]; other site 266940002846 Mechanosensitive ion channel; Region: MS_channel; pfam00924 266940002847 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 266940002848 Uncharacterized conserved protein [Function unknown]; Region: COG4095 266940002849 putative acetyltransferase; Provisional; Region: PRK03624 266940002850 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266940002851 Coenzyme A binding pocket [chemical binding]; other site 266940002852 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854 266940002853 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 266940002854 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 266940002855 chorismate binding enzyme; Region: Chorismate_bind; cl10555 266940002856 Glutamine amidotransferase class-I; Region: GATase; pfam00117 266940002857 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 266940002858 glutamine binding [chemical binding]; other site 266940002859 catalytic triad [active] 266940002860 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266940002861 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266940002862 active site 266940002863 phosphorylation site [posttranslational modification] 266940002864 intermolecular recognition site; other site 266940002865 dimerization interface [polypeptide binding]; other site 266940002866 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266940002867 DNA binding residues [nucleotide binding] 266940002868 dimerization interface [polypeptide binding]; other site 266940002869 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 266940002870 Histidine kinase; Region: HisKA_3; pfam07730 266940002871 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 266940002872 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 266940002873 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940002874 Walker A/P-loop; other site 266940002875 ATP binding site [chemical binding]; other site 266940002876 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 266940002877 active site 266940002878 metal binding site [ion binding]; metal-binding site 266940002879 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 266940002880 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 266940002881 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 266940002882 Uncharacterized conserved protein [Function unknown]; Region: COG1615 266940002883 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 266940002884 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 266940002885 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 266940002886 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 266940002887 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 266940002888 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 266940002889 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266940002890 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266940002891 TM-ABC transporter signature motif; other site 266940002892 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266940002893 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266940002894 Walker A/P-loop; other site 266940002895 ATP binding site [chemical binding]; other site 266940002896 Q-loop/lid; other site 266940002897 ABC transporter signature motif; other site 266940002898 Walker B; other site 266940002899 D-loop; other site 266940002900 H-loop/switch region; other site 266940002901 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 266940002902 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 266940002903 putative ligand binding site [chemical binding]; other site 266940002904 Protein of unknown function DUF45; Region: DUF45; cl00636 266940002905 Transcription factor WhiB; Region: Whib; pfam02467 266940002906 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 266940002907 Part of AAA domain; Region: AAA_19; pfam13245 266940002908 Family description; Region: UvrD_C_2; pfam13538 266940002909 HRDC domain; Region: HRDC; pfam00570 266940002910 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 266940002911 catalytic residues [active] 266940002912 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 266940002913 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 266940002914 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 266940002915 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 266940002916 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 266940002917 putative NADH binding site [chemical binding]; other site 266940002918 putative active site [active] 266940002919 nudix motif; other site 266940002920 putative metal binding site [ion binding]; other site 266940002921 Phosphotransferase enzyme family; Region: APH; pfam01636 266940002922 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 266940002923 substrate binding site [chemical binding]; other site 266940002924 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 266940002925 putative catalytic site [active] 266940002926 putative phosphate binding site [ion binding]; other site 266940002927 putative metal binding site [ion binding]; other site 266940002928 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 266940002929 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 266940002930 putative acyl-acceptor binding pocket; other site 266940002931 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 266940002932 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 266940002933 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 266940002934 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 266940002935 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 266940002936 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 266940002937 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 266940002938 FAD binding site [chemical binding]; other site 266940002939 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 266940002940 active site 266940002941 DNA binding site [nucleotide binding] 266940002942 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 266940002943 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 266940002944 helicase 45; Provisional; Region: PTZ00424 266940002945 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 266940002946 ATP binding site [chemical binding]; other site 266940002947 Mg++ binding site [ion binding]; other site 266940002948 motif III; other site 266940002949 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266940002950 nucleotide binding region [chemical binding]; other site 266940002951 ATP-binding site [chemical binding]; other site 266940002952 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 266940002953 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 266940002954 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 266940002955 active site 266940002956 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 266940002957 proline aminopeptidase P II; Provisional; Region: PRK10879 266940002958 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 266940002959 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 266940002960 active site 266940002961 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 266940002962 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 266940002963 dimerization interface [polypeptide binding]; other site 266940002964 DPS ferroxidase diiron center [ion binding]; other site 266940002965 ion pore; other site 266940002966 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 266940002967 MgtE intracellular N domain; Region: MgtE_N; smart00924 266940002968 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 266940002969 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 266940002970 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 266940002971 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 266940002972 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 266940002973 Walker A motif; other site 266940002974 ATP binding site [chemical binding]; other site 266940002975 Walker B motif; other site 266940002976 Domain of unknown function DUF59; Region: DUF59; cl00941 266940002977 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 266940002978 sec-independent translocase; Provisional; Region: PRK01371 266940002979 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 266940002980 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 266940002981 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 266940002982 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 266940002983 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266940002984 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266940002985 DNA binding residues [nucleotide binding] 266940002986 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266940002987 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cl08294 266940002988 interface (dimer of trimers) [polypeptide binding]; other site 266940002989 Substrate-binding/catalytic site; other site 266940002990 Zn-binding sites [ion binding]; other site 266940002991 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 266940002992 DivIVA domain; Region: DivI1A_domain; TIGR03544 266940002993 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 266940002994 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 266940002995 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 266940002996 metal binding site [ion binding]; metal-binding site 266940002997 putative dimer interface [polypeptide binding]; other site 266940002998 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 266940002999 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 266940003000 putative trimer interface [polypeptide binding]; other site 266940003001 putative CoA binding site [chemical binding]; other site 266940003002 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 266940003003 dimer interface [polypeptide binding]; other site 266940003004 Citrate synthase; Region: Citrate_synt; pfam00285 266940003005 active site 266940003006 citrylCoA binding site [chemical binding]; other site 266940003007 NADH binding [chemical binding]; other site 266940003008 cationic pore residues; other site 266940003009 oxalacetate/citrate binding site [chemical binding]; other site 266940003010 coenzyme A binding site [chemical binding]; other site 266940003011 catalytic triad [active] 266940003012 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 266940003013 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266940003014 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266940003015 homodimer interface [polypeptide binding]; other site 266940003016 catalytic residue [active] 266940003017 Ferredoxin [Energy production and conversion]; Region: COG1146 266940003018 4Fe-4S binding domain; Region: Fer4; pfam00037 266940003019 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 266940003020 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 266940003021 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266940003022 active site 266940003023 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 266940003024 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266940003025 Walker A motif; other site 266940003026 ATP binding site [chemical binding]; other site 266940003027 Walker B motif; other site 266940003028 Peptidase family M41; Region: Peptidase_M41; pfam01434 266940003029 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 266940003030 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 266940003031 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 266940003032 G1 box; other site 266940003033 putative GEF interaction site [polypeptide binding]; other site 266940003034 GTP/Mg2+ binding site [chemical binding]; other site 266940003035 Switch I region; other site 266940003036 G2 box; other site 266940003037 G3 box; other site 266940003038 Switch II region; other site 266940003039 G4 box; other site 266940003040 G5 box; other site 266940003041 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 266940003042 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 266940003043 BCCT family transporter; Region: BCCT; pfam02028 266940003044 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 266940003045 active site 266940003046 8-oxo-dGMP binding site [chemical binding]; other site 266940003047 nudix motif; other site 266940003048 metal binding site [ion binding]; metal-binding site 266940003049 Domain of unknown function (DUF305); Region: DUF305; pfam03713 266940003050 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 266940003051 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 266940003052 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266940003053 Walker A/P-loop; other site 266940003054 ATP binding site [chemical binding]; other site 266940003055 Q-loop/lid; other site 266940003056 ABC transporter signature motif; other site 266940003057 Walker B; other site 266940003058 D-loop; other site 266940003059 H-loop/switch region; other site 266940003060 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 266940003061 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266940003062 Walker A/P-loop; other site 266940003063 ATP binding site [chemical binding]; other site 266940003064 Q-loop/lid; other site 266940003065 ABC transporter signature motif; other site 266940003066 Walker B; other site 266940003067 D-loop; other site 266940003068 H-loop/switch region; other site 266940003069 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266940003070 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266940003071 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940003072 dimer interface [polypeptide binding]; other site 266940003073 conserved gate region; other site 266940003074 putative PBP binding loops; other site 266940003075 ABC-ATPase subunit interface; other site 266940003076 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266940003077 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940003078 dimer interface [polypeptide binding]; other site 266940003079 conserved gate region; other site 266940003080 putative PBP binding loops; other site 266940003081 ABC-ATPase subunit interface; other site 266940003082 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 266940003083 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 266940003084 GTP-binding protein YchF; Reviewed; Region: PRK09601 266940003085 YchF GTPase; Region: YchF; cd01900 266940003086 G1 box; other site 266940003087 GTP/Mg2+ binding site [chemical binding]; other site 266940003088 Switch I region; other site 266940003089 G2 box; other site 266940003090 Switch II region; other site 266940003091 G3 box; other site 266940003092 G4 box; other site 266940003093 G5 box; other site 266940003094 Protein of unknown function (DUF933); Region: YchF-GTPase_C; pfam06071 266940003095 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 266940003096 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 266940003097 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 266940003098 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 266940003099 generic binding surface II; other site 266940003100 generic binding surface I; other site 266940003101 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 266940003102 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 266940003103 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 266940003104 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 266940003105 putative active site [active] 266940003106 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266940003107 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 266940003108 putative substrate binding site [chemical binding]; other site 266940003109 putative ATP binding site [chemical binding]; other site 266940003110 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 266940003111 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 266940003112 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 266940003113 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 266940003114 Walker A/P-loop; other site 266940003115 ATP binding site [chemical binding]; other site 266940003116 Q-loop/lid; other site 266940003117 ABC transporter signature motif; other site 266940003118 Walker B; other site 266940003119 D-loop; other site 266940003120 H-loop/switch region; other site 266940003121 TOBE domain; Region: TOBE_2; pfam08402 266940003122 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266940003123 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940003124 dimer interface [polypeptide binding]; other site 266940003125 conserved gate region; other site 266940003126 putative PBP binding loops; other site 266940003127 ABC-ATPase subunit interface; other site 266940003128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940003129 dimer interface [polypeptide binding]; other site 266940003130 conserved gate region; other site 266940003131 putative PBP binding loops; other site 266940003132 ABC-ATPase subunit interface; other site 266940003133 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 266940003134 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266940003135 fumarate hydratase; Reviewed; Region: fumC; PRK00485 266940003136 aspartase (L-aspartate ammonia-lyase) and fumarase class II enzymes; Region: Aspartase_like; cd01596 266940003137 active sites [active] 266940003138 tetramer interface [polypeptide binding]; other site 266940003139 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 266940003140 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 266940003141 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 266940003142 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266940003143 RNA binding surface [nucleotide binding]; other site 266940003144 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 266940003145 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 266940003146 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 266940003147 putative active site [active] 266940003148 PhoH-like protein; Region: PhoH; pfam02562 266940003149 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 266940003150 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 266940003151 catalytic residue [active] 266940003152 putative FPP diphosphate binding site; other site 266940003153 putative FPP binding hydrophobic cleft; other site 266940003154 dimer interface [polypeptide binding]; other site 266940003155 putative IPP diphosphate binding site; other site 266940003156 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266940003157 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266940003158 Haemolysin-III related; Region: HlyIII; pfam03006 266940003159 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 266940003160 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 266940003161 catalytic residues [active] 266940003162 Cell morphogenesis N-terminal; Region: MOR2-PAG1_N; pfam14222 266940003163 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266940003164 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266940003165 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 266940003166 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 266940003167 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 266940003168 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 266940003169 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 266940003170 Domain of unknown function DUF20; Region: UPF0118; pfam01594 266940003171 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 266940003172 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 266940003173 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 266940003174 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 266940003175 tetrameric interface [polypeptide binding]; other site 266940003176 NAD binding site [chemical binding]; other site 266940003177 catalytic residues [active] 266940003178 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 266940003179 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 266940003180 metal ion-dependent adhesion site (MIDAS); other site 266940003181 H+ Antiporter protein; Region: 2A0121; TIGR00900 266940003182 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940003183 cystathionine gamma-synthase; Provisional; Region: PRK07811 266940003184 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 266940003185 homodimer interface [polypeptide binding]; other site 266940003186 substrate-cofactor binding pocket; other site 266940003187 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266940003188 catalytic residue [active] 266940003189 methionine sulfoxide reductase A; Provisional; Region: PRK00058 266940003190 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266940003191 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266940003192 DNA binding residues [nucleotide binding] 266940003193 dimerization interface [polypeptide binding]; other site 266940003194 Protein of unknown function (DUF993); Region: DUF993; pfam06187 266940003195 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266940003196 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 266940003197 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 266940003198 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 266940003199 Walker A/P-loop; other site 266940003200 ATP binding site [chemical binding]; other site 266940003201 Q-loop/lid; other site 266940003202 ABC transporter signature motif; other site 266940003203 Walker B; other site 266940003204 D-loop; other site 266940003205 H-loop/switch region; other site 266940003206 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 266940003207 FtsX-like permease family; Region: FtsX; pfam02687 266940003208 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 266940003209 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 266940003210 dimer interface [polypeptide binding]; other site 266940003211 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266940003212 catalytic residue [active] 266940003213 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 266940003214 Bax inhibitor 1 like; Region: BaxI_1; cl17691 266940003215 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 266940003216 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 266940003217 Fe-S cluster binding site [ion binding]; other site 266940003218 DNA binding site [nucleotide binding] 266940003219 active site 266940003220 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 266940003221 hydrophobic ligand binding site; other site 266940003222 Protein of unknown function (DUF419); Region: DUF419; pfam04237 266940003223 exopolyphosphatase; Region: exo_poly_only; TIGR03706 266940003224 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 266940003225 Protein of unknown function (DUF501); Region: DUF501; pfam04417 266940003226 Septum formation initiator; Region: DivIC; pfam04977 266940003227 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 266940003228 enolase; Provisional; Region: eno; PRK00077 266940003229 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 266940003230 dimer interface [polypeptide binding]; other site 266940003231 metal binding site [ion binding]; metal-binding site 266940003232 substrate binding pocket [chemical binding]; other site 266940003233 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 266940003234 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 266940003235 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 266940003236 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 266940003237 homodimer interface [polypeptide binding]; other site 266940003238 metal binding site [ion binding]; metal-binding site 266940003239 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 266940003240 active site 266940003241 catalytic triad [active] 266940003242 oxyanion hole [active] 266940003243 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 266940003244 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 266940003245 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 266940003246 HYR domain; Region: HYR; pfam02494 266940003247 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 266940003248 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 266940003249 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266940003250 ATP binding site [chemical binding]; other site 266940003251 putative Mg++ binding site [ion binding]; other site 266940003252 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266940003253 nucleotide binding region [chemical binding]; other site 266940003254 ATP-binding site [chemical binding]; other site 266940003255 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 266940003256 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 266940003257 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266940003258 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 266940003259 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 266940003260 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 266940003261 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266940003262 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 266940003263 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 266940003264 Predicted membrane protein [Function unknown]; Region: COG4906 266940003265 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 266940003266 Ligand binding site; other site 266940003267 Putative Catalytic site; other site 266940003268 DXD motif; other site 266940003269 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 266940003270 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266940003271 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 266940003272 putative active site [active] 266940003273 catalytic residue [active] 266940003274 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 266940003275 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 266940003276 5S rRNA interface [nucleotide binding]; other site 266940003277 CTC domain interface [polypeptide binding]; other site 266940003278 L16 interface [polypeptide binding]; other site 266940003279 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 266940003280 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 266940003281 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266940003282 active site 266940003283 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 266940003284 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 266940003285 Substrate binding site; other site 266940003286 Mg++ binding site; other site 266940003287 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 266940003288 active site 266940003289 substrate binding site [chemical binding]; other site 266940003290 CoA binding site [chemical binding]; other site 266940003291 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266940003292 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266940003293 MarR family; Region: MarR_2; pfam12802 266940003294 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 266940003295 Bacterial sugar transferase; Region: Bac_transf; pfam02397 266940003296 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 266940003297 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940003298 Walker A/P-loop; other site 266940003299 ATP binding site [chemical binding]; other site 266940003300 Q-loop/lid; other site 266940003301 ABC transporter signature motif; other site 266940003302 Walker B; other site 266940003303 D-loop; other site 266940003304 H-loop/switch region; other site 266940003305 ABC transporter; Region: ABC_tran_2; pfam12848 266940003306 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266940003307 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 266940003308 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 266940003309 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266940003310 S-adenosylmethionine binding site [chemical binding]; other site 266940003311 Domain of unknown function (DUF348); Region: DUF348; pfam03990 266940003312 Domain of unknown function (DUF348); Region: DUF348; pfam03990 266940003313 Domain of unknown function (DUF348); Region: DUF348; pfam03990 266940003314 G5 domain; Region: G5; pfam07501 266940003315 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266940003316 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266940003317 catalytic residue [active] 266940003318 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 266940003319 active site 266940003320 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 266940003321 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 266940003322 active site 266940003323 HIGH motif; other site 266940003324 KMSKS motif; other site 266940003325 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 266940003326 tRNA binding surface [nucleotide binding]; other site 266940003327 anticodon binding site; other site 266940003328 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 266940003329 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 266940003330 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 266940003331 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 266940003332 NADP binding site [chemical binding]; other site 266940003333 dimer interface [polypeptide binding]; other site 266940003334 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266940003335 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266940003336 DNA binding site [nucleotide binding] 266940003337 domain linker motif; other site 266940003338 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 266940003339 dimerization interface [polypeptide binding]; other site 266940003340 ligand binding site [chemical binding]; other site 266940003341 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 266940003342 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 266940003343 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 266940003344 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 266940003345 active site 266940003346 substrate binding site [chemical binding]; other site 266940003347 Mg2+ binding site [ion binding]; other site 266940003348 Predicted transcriptional regulators [Transcription]; Region: COG1695 266940003349 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 266940003350 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 266940003351 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266940003352 active site 266940003353 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266940003354 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 266940003355 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 266940003356 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266940003357 catalytic residue [active] 266940003358 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 266940003359 homotrimer interaction site [polypeptide binding]; other site 266940003360 putative active site [active] 266940003361 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940003362 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940003363 active site 266940003364 I-site; other site 266940003365 metal binding site [ion binding]; metal-binding site 266940003366 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266940003367 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266940003368 catalytic core [active] 266940003369 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 266940003370 active site clefts [active] 266940003371 zinc binding site [ion binding]; other site 266940003372 dimer interface [polypeptide binding]; other site 266940003373 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940003374 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940003375 metal binding site [ion binding]; metal-binding site 266940003376 active site 266940003377 I-site; other site 266940003378 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266940003379 short chain dehydrogenase; Provisional; Region: PRK08263 266940003380 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 266940003381 NADP binding site [chemical binding]; other site 266940003382 active site 266940003383 steroid binding site; other site 266940003384 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 266940003385 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940003386 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 266940003387 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 266940003388 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266940003389 Bacterial transcriptional regulator; Region: IclR; pfam01614 266940003390 glycerol kinase; Region: glycerol_kin; TIGR01311 266940003391 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 266940003392 N- and C-terminal domain interface [polypeptide binding]; other site 266940003393 active site 266940003394 MgATP binding site [chemical binding]; other site 266940003395 catalytic site [active] 266940003396 metal binding site [ion binding]; metal-binding site 266940003397 putative homotetramer interface [polypeptide binding]; other site 266940003398 glycerol binding site [chemical binding]; other site 266940003399 homodimer interface [polypeptide binding]; other site 266940003400 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266940003401 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266940003402 active site 266940003403 phosphorylation site [posttranslational modification] 266940003404 intermolecular recognition site; other site 266940003405 dimerization interface [polypeptide binding]; other site 266940003406 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266940003407 DNA binding site [nucleotide binding] 266940003408 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 266940003409 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 266940003410 Ligand Binding Site [chemical binding]; other site 266940003411 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266940003412 dimer interface [polypeptide binding]; other site 266940003413 phosphorylation site [posttranslational modification] 266940003414 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266940003415 Mg2+ binding site [ion binding]; other site 266940003416 G-X-G motif; other site 266940003417 K+-transporting ATPase, c chain; Region: KdpC; cl00944 266940003418 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 266940003419 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266940003420 Soluble P-type ATPase [General function prediction only]; Region: COG4087 266940003421 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 266940003422 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 266940003423 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940003424 putative substrate translocation pore; other site 266940003425 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940003426 SNF2 Helicase protein; Region: DUF3670; pfam12419 266940003427 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 266940003428 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266940003429 ATP binding site [chemical binding]; other site 266940003430 putative Mg++ binding site [ion binding]; other site 266940003431 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266940003432 nucleotide binding region [chemical binding]; other site 266940003433 ATP-binding site [chemical binding]; other site 266940003434 Uncharacterized conserved protein [Function unknown]; Region: COG4279 266940003435 SWIM zinc finger; Region: SWIM; pfam04434 266940003436 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 266940003437 catalytic triad [active] 266940003438 CARDB; Region: CARDB; pfam07705 266940003439 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 266940003440 glycerol kinase; Provisional; Region: glpK; PRK00047 266940003441 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 266940003442 N- and C-terminal domain interface [polypeptide binding]; other site 266940003443 active site 266940003444 MgATP binding site [chemical binding]; other site 266940003445 catalytic site [active] 266940003446 metal binding site [ion binding]; metal-binding site 266940003447 putative homotetramer interface [polypeptide binding]; other site 266940003448 glycerol binding site [chemical binding]; other site 266940003449 homodimer interface [polypeptide binding]; other site 266940003450 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 266940003451 amphipathic channel; other site 266940003452 Asn-Pro-Ala signature motifs; other site 266940003453 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266940003454 short chain dehydrogenase; Provisional; Region: PRK08251 266940003455 classical (c) SDRs; Region: SDR_c; cd05233 266940003456 NAD(P) binding site [chemical binding]; other site 266940003457 active site 266940003458 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 266940003459 GAF domain; Region: GAF; pfam01590 266940003460 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 266940003461 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 266940003462 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 266940003463 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 266940003464 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266940003465 dimerization interface [polypeptide binding]; other site 266940003466 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 266940003467 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266940003468 dimer interface [polypeptide binding]; other site 266940003469 putative CheW interface [polypeptide binding]; other site 266940003470 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266940003471 FAD binding domain; Region: FAD_binding_4; pfam01565 266940003472 Dehydroquinase class II; Region: DHquinase_II; pfam01220 266940003473 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 266940003474 trimer interface [polypeptide binding]; other site 266940003475 active site 266940003476 dimer interface [polypeptide binding]; other site 266940003477 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 266940003478 Putative NAD(P)-binding; Region: NAD_binding_7; cl17660 266940003479 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 266940003480 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266940003481 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 266940003482 active site 266940003483 metal binding site [ion binding]; metal-binding site 266940003484 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 266940003485 AAA domain; Region: AAA_30; pfam13604 266940003486 Family description; Region: UvrD_C_2; pfam13538 266940003487 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 266940003488 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 266940003489 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 266940003490 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 266940003491 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 266940003492 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 266940003493 Uncharacterized conserved protein [Function unknown]; Region: COG2966 266940003494 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 266940003495 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 266940003496 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 266940003497 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 266940003498 active site 266940003499 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266940003500 catalytic core [active] 266940003501 Domain of unknown function (DUF385); Region: DUF385; pfam04075 266940003502 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266940003503 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266940003504 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 266940003505 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 266940003506 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266940003507 substrate binding site [chemical binding]; other site 266940003508 dimer interface [polypeptide binding]; other site 266940003509 ATP binding site [chemical binding]; other site 266940003510 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 266940003511 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 266940003512 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 266940003513 FeoA domain; Region: FeoA; pfam04023 266940003514 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266940003515 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266940003516 catalytic residue [active] 266940003517 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266940003518 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 266940003519 active site 266940003520 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266940003521 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266940003522 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 266940003523 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 266940003524 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266940003525 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940003526 dimer interface [polypeptide binding]; other site 266940003527 conserved gate region; other site 266940003528 putative PBP binding loops; other site 266940003529 ABC-ATPase subunit interface; other site 266940003530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266940003531 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940003532 ABC-ATPase subunit interface; other site 266940003533 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266940003534 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266940003535 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 266940003536 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266940003537 DNA binding site [nucleotide binding] 266940003538 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 266940003539 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 266940003540 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266940003541 active site 266940003542 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266940003543 catalytic tetrad [active] 266940003544 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 266940003545 LGFP repeat; Region: LGFP; pfam08310 266940003546 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 266940003547 LGFP repeat; Region: LGFP; pfam08310 266940003548 LGFP repeat; Region: LGFP; pfam08310 266940003549 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 266940003550 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 266940003551 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 266940003552 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 266940003553 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940003554 dimer interface [polypeptide binding]; other site 266940003555 conserved gate region; other site 266940003556 putative PBP binding loops; other site 266940003557 ABC-ATPase subunit interface; other site 266940003558 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266940003559 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940003560 dimer interface [polypeptide binding]; other site 266940003561 conserved gate region; other site 266940003562 putative PBP binding loops; other site 266940003563 ABC-ATPase subunit interface; other site 266940003564 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 266940003565 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 266940003566 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 266940003567 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 266940003568 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 266940003569 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 266940003570 putative dimer interface [polypeptide binding]; other site 266940003571 Helix-turn-helix domain; Region: HTH_18; pfam12833 266940003572 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266940003573 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 266940003574 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 266940003575 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 266940003576 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 266940003577 Beta-lactamase; Region: Beta-lactamase; pfam00144 266940003578 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940003579 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940003580 metal binding site [ion binding]; metal-binding site 266940003581 active site 266940003582 I-site; other site 266940003583 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266940003584 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266940003585 Ligand Binding Site [chemical binding]; other site 266940003586 GAF domain; Region: GAF; pfam01590 266940003587 GAF domain; Region: GAF_2; pfam13185 266940003588 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266940003589 PAS fold; Region: PAS_3; pfam08447 266940003590 putative active site [active] 266940003591 heme pocket [chemical binding]; other site 266940003592 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266940003593 PAS domain; Region: PAS_9; pfam13426 266940003594 putative active site [active] 266940003595 heme pocket [chemical binding]; other site 266940003596 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 266940003597 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 266940003598 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 266940003599 aminotransferase; Validated; Region: PRK07337 266940003600 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266940003601 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266940003602 homodimer interface [polypeptide binding]; other site 266940003603 catalytic residue [active] 266940003604 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 266940003605 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 266940003606 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 266940003607 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266940003608 Walker A/P-loop; other site 266940003609 ATP binding site [chemical binding]; other site 266940003610 Q-loop/lid; other site 266940003611 ABC transporter signature motif; other site 266940003612 Walker B; other site 266940003613 D-loop; other site 266940003614 H-loop/switch region; other site 266940003615 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266940003616 Walker A/P-loop; other site 266940003617 ATP binding site [chemical binding]; other site 266940003618 Q-loop/lid; other site 266940003619 ABC transporter signature motif; other site 266940003620 Walker B; other site 266940003621 D-loop; other site 266940003622 H-loop/switch region; other site 266940003623 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266940003624 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266940003625 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940003626 dimer interface [polypeptide binding]; other site 266940003627 conserved gate region; other site 266940003628 putative PBP binding loops; other site 266940003629 ABC-ATPase subunit interface; other site 266940003630 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266940003631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266940003632 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266940003633 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266940003634 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 266940003635 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 266940003636 substrate binding site [chemical binding]; other site 266940003637 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 266940003638 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 266940003639 THF binding site; other site 266940003640 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 266940003641 substrate binding site [chemical binding]; other site 266940003642 THF binding site; other site 266940003643 zinc-binding site [ion binding]; other site 266940003644 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 266940003645 FAD binding site [chemical binding]; other site 266940003646 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 266940003647 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266940003648 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266940003649 catalytic residue [active] 266940003650 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 266940003651 active site residue [active] 266940003652 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 266940003653 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 266940003654 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 266940003655 active site 266940003656 non-prolyl cis peptide bond; other site 266940003657 ATP-grasp domain; Region: ATP-grasp_4; cl17255 266940003658 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 266940003659 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266940003660 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940003661 dimer interface [polypeptide binding]; other site 266940003662 conserved gate region; other site 266940003663 putative PBP binding loops; other site 266940003664 ABC-ATPase subunit interface; other site 266940003665 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 266940003666 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940003667 Walker A/P-loop; other site 266940003668 ATP binding site [chemical binding]; other site 266940003669 Q-loop/lid; other site 266940003670 ABC transporter signature motif; other site 266940003671 Walker B; other site 266940003672 D-loop; other site 266940003673 H-loop/switch region; other site 266940003674 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266940003675 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266940003676 substrate binding pocket [chemical binding]; other site 266940003677 membrane-bound complex binding site; other site 266940003678 hinge residues; other site 266940003679 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 266940003680 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 266940003681 Predicted acetyltransferase [General function prediction only]; Region: COG2388 266940003682 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266940003683 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266940003684 DNA binding site [nucleotide binding] 266940003685 domain linker motif; other site 266940003686 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 266940003687 dimerization interface [polypeptide binding]; other site 266940003688 ligand binding site [chemical binding]; other site 266940003689 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 266940003690 Catalytic domain of Protein Kinases; Region: PKc; cd00180 266940003691 active site 266940003692 ATP binding site [chemical binding]; other site 266940003693 substrate binding site [chemical binding]; other site 266940003694 activation loop (A-loop); other site 266940003695 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 266940003696 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 266940003697 active site 266940003698 homotetramer interface [polypeptide binding]; other site 266940003699 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 266940003700 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 266940003701 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 266940003702 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 266940003703 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 266940003704 TrkA-C domain; Region: TrkA_C; pfam02080 266940003705 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 266940003706 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 266940003707 Walker A/P-loop; other site 266940003708 ATP binding site [chemical binding]; other site 266940003709 Q-loop/lid; other site 266940003710 ABC transporter signature motif; other site 266940003711 Walker B; other site 266940003712 D-loop; other site 266940003713 H-loop/switch region; other site 266940003714 TOBE domain; Region: TOBE_2; pfam08402 266940003715 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 266940003716 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940003717 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266940003718 NAD(P) binding site [chemical binding]; other site 266940003719 active site 266940003720 MarR family; Region: MarR; pfam01047 266940003721 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 266940003722 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 266940003723 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 266940003724 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 266940003725 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266940003726 active site 266940003727 HIGH motif; other site 266940003728 nucleotide binding site [chemical binding]; other site 266940003729 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 266940003730 KMSKS motif; other site 266940003731 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 266940003732 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 266940003733 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 266940003734 NAD binding site [chemical binding]; other site 266940003735 catalytic Zn binding site [ion binding]; other site 266940003736 substrate binding site [chemical binding]; other site 266940003737 structural Zn binding site [ion binding]; other site 266940003738 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266940003739 Cation efflux family; Region: Cation_efflux; pfam01545 266940003740 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 266940003741 Domain of unknown function DUF20; Region: UPF0118; pfam01594 266940003742 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266940003743 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266940003744 allophanate hydrolase; Provisional; Region: PRK08186 266940003745 Amidase; Region: Amidase; cl11426 266940003746 urea carboxylase; Region: urea_carbox; TIGR02712 266940003747 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266940003748 ATP-grasp domain; Region: ATP-grasp_4; cl17255 266940003749 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 266940003750 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 266940003751 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 266940003752 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 266940003753 carboxyltransferase (CT) interaction site; other site 266940003754 biotinylation site [posttranslational modification]; other site 266940003755 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 266940003756 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 266940003757 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 266940003758 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 266940003759 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 266940003760 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Reviewed; Region: ispF; PRK00084 266940003761 homotrimer interaction site [polypeptide binding]; other site 266940003762 zinc binding site [ion binding]; other site 266940003763 CDP-binding sites; other site 266940003764 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266940003765 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 266940003766 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266940003767 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266940003768 active site 266940003769 phosphorylation site [posttranslational modification] 266940003770 intermolecular recognition site; other site 266940003771 dimerization interface [polypeptide binding]; other site 266940003772 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266940003773 DNA binding site [nucleotide binding] 266940003774 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266940003775 dimer interface [polypeptide binding]; other site 266940003776 phosphorylation site [posttranslational modification] 266940003777 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266940003778 ATP binding site [chemical binding]; other site 266940003779 Mg2+ binding site [ion binding]; other site 266940003780 G-X-G motif; other site 266940003781 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 266940003782 PhoU domain; Region: PhoU; pfam01895 266940003783 PhoU domain; Region: PhoU; pfam01895 266940003784 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 266940003785 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 266940003786 putative ADP-binding pocket [chemical binding]; other site 266940003787 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266940003788 catalytic core [active] 266940003789 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266940003790 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 266940003791 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 266940003792 putative ADP-binding pocket [chemical binding]; other site 266940003793 Methyltransferase domain; Region: Methyltransf_18; pfam12847 266940003794 D-tyrosyl-tRNA(Tyr) deacylase; Provisional; Region: PRK05273 266940003795 dimerization interface [polypeptide binding]; other site 266940003796 putative tRNAtyr binding site [nucleotide binding]; other site 266940003797 putative active site [active] 266940003798 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 266940003799 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 266940003800 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 266940003801 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266940003802 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266940003803 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 266940003804 metal binding site 2 [ion binding]; metal-binding site 266940003805 putative DNA binding helix; other site 266940003806 metal binding site 1 [ion binding]; metal-binding site 266940003807 dimer interface [polypeptide binding]; other site 266940003808 structural Zn2+ binding site [ion binding]; other site 266940003809 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 266940003810 heme-binding site [chemical binding]; other site 266940003811 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266940003812 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266940003813 DNA binding site [nucleotide binding] 266940003814 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 266940003815 polyphosphate kinase; Provisional; Region: PRK05443 266940003816 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 266940003817 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 266940003818 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 266940003819 putative domain interface [polypeptide binding]; other site 266940003820 putative active site [active] 266940003821 catalytic site [active] 266940003822 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 266940003823 putative domain interface [polypeptide binding]; other site 266940003824 putative active site [active] 266940003825 catalytic site [active] 266940003826 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 266940003827 active site 266940003828 Ap6A binding site [chemical binding]; other site 266940003829 nudix motif; other site 266940003830 metal binding site [ion binding]; metal-binding site 266940003831 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 266940003832 catalytic core [active] 266940003833 PBP superfamily domain; Region: PBP_like_2; cl17296 266940003834 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 266940003835 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940003836 dimer interface [polypeptide binding]; other site 266940003837 conserved gate region; other site 266940003838 putative PBP binding loops; other site 266940003839 ABC-ATPase subunit interface; other site 266940003840 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 266940003841 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940003842 dimer interface [polypeptide binding]; other site 266940003843 conserved gate region; other site 266940003844 putative PBP binding loops; other site 266940003845 ABC-ATPase subunit interface; other site 266940003846 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 266940003847 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 266940003848 Walker A/P-loop; other site 266940003849 ATP binding site [chemical binding]; other site 266940003850 Q-loop/lid; other site 266940003851 ABC transporter signature motif; other site 266940003852 Walker B; other site 266940003853 D-loop; other site 266940003854 H-loop/switch region; other site 266940003855 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 266940003856 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 266940003857 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 266940003858 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 266940003859 active site 266940003860 metal binding site [ion binding]; metal-binding site 266940003861 oxidoreductase; Provisional; Region: PRK12743 266940003862 classical (c) SDRs; Region: SDR_c; cd05233 266940003863 NAD(P) binding site [chemical binding]; other site 266940003864 active site 266940003865 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 266940003866 metal binding site 2 [ion binding]; metal-binding site 266940003867 putative DNA binding helix; other site 266940003868 metal binding site 1 [ion binding]; metal-binding site 266940003869 dimer interface [polypeptide binding]; other site 266940003870 structural Zn2+ binding site [ion binding]; other site 266940003871 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 266940003872 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 266940003873 tetramer interface [polypeptide binding]; other site 266940003874 heme binding pocket [chemical binding]; other site 266940003875 Predicted transcriptional regulators [Transcription]; Region: COG1733 266940003876 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 266940003877 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940003878 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 266940003879 NAD(P) binding site [chemical binding]; other site 266940003880 active site 266940003881 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 266940003882 Beta-lactamase; Region: Beta-lactamase; pfam00144 266940003883 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 266940003884 OsmC-like protein; Region: OsmC; cl00767 266940003885 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 266940003886 DEAD-like helicases superfamily; Region: DEXDc; smart00487 266940003887 ATP binding site [chemical binding]; other site 266940003888 Mg++ binding site [ion binding]; other site 266940003889 motif III; other site 266940003890 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266940003891 nucleotide binding region [chemical binding]; other site 266940003892 ATP-binding site [chemical binding]; other site 266940003893 phosphate acetyltransferase; Reviewed; Region: PRK05632 266940003894 DRTGG domain; Region: DRTGG; pfam07085 266940003895 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 266940003896 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 266940003897 propionate/acetate kinase; Provisional; Region: PRK12379 266940003898 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 266940003899 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 266940003900 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 266940003901 dimer interface [polypeptide binding]; other site 266940003902 substrate binding site [chemical binding]; other site 266940003903 ATP binding site [chemical binding]; other site 266940003904 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 266940003905 thiamine phosphate binding site [chemical binding]; other site 266940003906 active site 266940003907 pyrophosphate binding site [ion binding]; other site 266940003908 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 266940003909 substrate binding site [chemical binding]; other site 266940003910 ATP binding site [chemical binding]; other site 266940003911 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 266940003912 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266940003913 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266940003914 active site 266940003915 catalytic tetrad [active] 266940003916 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 266940003917 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 266940003918 catalytic residues [active] 266940003919 DNA topoisomerase IV subunit A; Provisional; Region: PRK13979 266940003920 Excalibur calcium-binding domain; Region: Excalibur; smart00894 266940003921 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 266940003922 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 266940003923 tetrameric interface [polypeptide binding]; other site 266940003924 NAD binding site [chemical binding]; other site 266940003925 catalytic residues [active] 266940003926 substrate binding site [chemical binding]; other site 266940003927 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 266940003928 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 266940003929 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266940003930 Ligand Binding Site [chemical binding]; other site 266940003931 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 266940003932 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266940003933 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266940003934 tetracycline repressor protein TetR; Provisional; Region: PRK13756 266940003935 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 266940003936 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 266940003937 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 266940003938 putative NAD(P) binding site [chemical binding]; other site 266940003939 catalytic Zn binding site [ion binding]; other site 266940003940 urease subunit alpha; Reviewed; Region: ureC; PRK13207 266940003941 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266940003942 active site 266940003943 bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192 266940003944 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 266940003945 alpha-gamma subunit interface [polypeptide binding]; other site 266940003946 beta-gamma subunit interface [polypeptide binding]; other site 266940003947 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cl00533 266940003948 alpha-beta subunit interface [polypeptide binding]; other site 266940003949 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 266940003950 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 266940003951 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 266940003952 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 266940003953 GAF domain; Region: GAF; pfam01590 266940003954 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 266940003955 Predicted membrane protein [Function unknown]; Region: COG2860 266940003956 UPF0126 domain; Region: UPF0126; pfam03458 266940003957 UPF0126 domain; Region: UPF0126; pfam03458 266940003958 DEAD-like helicases superfamily; Region: DEXDc; smart00487 266940003959 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266940003960 ATP binding site [chemical binding]; other site 266940003961 putative Mg++ binding site [ion binding]; other site 266940003962 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266940003963 nucleotide binding region [chemical binding]; other site 266940003964 ATP-binding site [chemical binding]; other site 266940003965 oxidoreductase; Provisional; Region: PRK06128 266940003966 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940003967 NAD(P) binding site [chemical binding]; other site 266940003968 active site 266940003969 spore photoproduct lyase family protein; Region: lyase_spl_fam; TIGR03886 266940003970 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 266940003971 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 266940003972 putative hydrophobic ligand binding site [chemical binding]; other site 266940003973 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 266940003974 PRC-barrel domain; Region: PRC; pfam05239 266940003975 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 266940003976 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 266940003977 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266940003978 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266940003979 DNA binding residues [nucleotide binding] 266940003980 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266940003981 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940003982 NAD(P) binding site [chemical binding]; other site 266940003983 active site 266940003984 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 266940003985 iron-sulfur cluster [ion binding]; other site 266940003986 [2Fe-2S] cluster binding site [ion binding]; other site 266940003987 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 266940003988 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 266940003989 NAD binding site [chemical binding]; other site 266940003990 catalytic Zn binding site [ion binding]; other site 266940003991 structural Zn binding site [ion binding]; other site 266940003992 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 266940003993 active site 266940003994 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 266940003995 dimanganese center [ion binding]; other site 266940003996 OsmC-like protein; Region: OsmC; cl00767 266940003997 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 266940003998 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 266940003999 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 266940004000 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 266940004001 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 266940004002 intersubunit interface [polypeptide binding]; other site 266940004003 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 266940004004 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 266940004005 dimer interface [polypeptide binding]; other site 266940004006 putative radical transfer pathway; other site 266940004007 diiron center [ion binding]; other site 266940004008 tyrosyl radical; other site 266940004009 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 266940004010 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 266940004011 Class I ribonucleotide reductase; Region: RNR_I; cd01679 266940004012 active site 266940004013 dimer interface [polypeptide binding]; other site 266940004014 catalytic residues [active] 266940004015 effector binding site; other site 266940004016 R2 peptide binding site; other site 266940004017 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 266940004018 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 266940004019 catalytic residues [active] 266940004020 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266940004021 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266940004022 DNA binding site [nucleotide binding] 266940004023 domain linker motif; other site 266940004024 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 266940004025 dimerization interface [polypeptide binding]; other site 266940004026 ligand binding site [chemical binding]; other site 266940004027 Domain of unknown function (DUF718); Region: DUF718; pfam05336 266940004028 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 266940004029 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940004030 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266940004031 classical (c) SDRs; Region: SDR_c; cd05233 266940004032 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 266940004033 NAD(P) binding site [chemical binding]; other site 266940004034 active site 266940004035 short chain dehydrogenase; Provisional; Region: PRK07454 266940004036 classical (c) SDRs; Region: SDR_c; cd05233 266940004037 NAD(P) binding site [chemical binding]; other site 266940004038 active site 266940004039 Isochorismatase family; Region: Isochorismatase; pfam00857 266940004040 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 266940004041 catalytic triad [active] 266940004042 conserved cis-peptide bond; other site 266940004043 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 266940004044 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266940004045 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266940004046 DNA binding residues [nucleotide binding] 266940004047 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 266940004048 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266940004049 active site 266940004050 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266940004051 active site 266940004052 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 266940004053 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 266940004054 putative hydrophobic ligand binding site [chemical binding]; other site 266940004055 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 266940004056 short chain dehydrogenase; Provisional; Region: PRK06180 266940004057 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 266940004058 NADP binding site [chemical binding]; other site 266940004059 active site 266940004060 steroid binding site; other site 266940004061 MOSC domain; Region: MOSC; pfam03473 266940004062 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 266940004063 putative homodimer interface [polypeptide binding]; other site 266940004064 putative homotetramer interface [polypeptide binding]; other site 266940004065 putative allosteric switch controlling residues; other site 266940004066 putative metal binding site [ion binding]; other site 266940004067 putative homodimer-homodimer interface [polypeptide binding]; other site 266940004068 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266940004069 metal-binding site [ion binding] 266940004070 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 266940004071 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266940004072 metal-binding site [ion binding] 266940004073 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266940004074 Soluble P-type ATPase [General function prediction only]; Region: COG4087 266940004075 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266940004076 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 266940004077 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940004078 NAD(P) binding site [chemical binding]; other site 266940004079 active site 266940004080 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266940004081 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 266940004082 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 266940004083 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266940004084 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266940004085 DNA binding site [nucleotide binding] 266940004086 domain linker motif; other site 266940004087 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 266940004088 dimerization interface [polypeptide binding]; other site 266940004089 ligand binding site [chemical binding]; other site 266940004090 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 266940004091 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 266940004092 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 266940004093 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266940004094 active site 266940004095 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 266940004096 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 266940004097 dimer interface [polypeptide binding]; other site 266940004098 active site 266940004099 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 266940004100 dimer interface [polypeptide binding]; other site 266940004101 active site 266940004102 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 266940004103 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 266940004104 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 266940004105 putative active site [active] 266940004106 D-cysteine desulfhydrase; Validated; Region: PRK03910 266940004107 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 266940004108 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266940004109 catalytic residue [active] 266940004110 FAD binding domain; Region: FAD_binding_4; pfam01565 266940004111 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 266940004112 argininosuccinate synthase; Validated; Region: PRK05370 266940004113 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 266940004114 putative deacylase active site [active] 266940004115 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 266940004116 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 266940004117 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266940004118 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 266940004119 Part of AAA domain; Region: AAA_19; pfam13245 266940004120 Family description; Region: UvrD_C_2; pfam13538 266940004121 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266940004122 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266940004123 MMPL family; Region: MMPL; pfam03176 266940004124 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 266940004125 nudix motif; other site 266940004126 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 266940004127 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 266940004128 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266940004129 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266940004130 DNA-binding site [nucleotide binding]; DNA binding site 266940004131 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266940004132 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266940004133 homodimer interface [polypeptide binding]; other site 266940004134 catalytic residue [active] 266940004135 PAS fold; Region: PAS_4; pfam08448 266940004136 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266940004137 putative active site [active] 266940004138 heme pocket [chemical binding]; other site 266940004139 GAF domain; Region: GAF; cl17456 266940004140 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 266940004141 GMP synthase; Reviewed; Region: guaA; PRK00074 266940004142 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 266940004143 AMP/PPi binding site [chemical binding]; other site 266940004144 candidate oxyanion hole; other site 266940004145 catalytic triad [active] 266940004146 potential glutamine specificity residues [chemical binding]; other site 266940004147 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 266940004148 ATP Binding subdomain [chemical binding]; other site 266940004149 Ligand Binding sites [chemical binding]; other site 266940004150 Dimerization subdomain; other site 266940004151 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 266940004152 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940004153 Walker A/P-loop; other site 266940004154 ATP binding site [chemical binding]; other site 266940004155 Q-loop/lid; other site 266940004156 ABC transporter signature motif; other site 266940004157 Walker B; other site 266940004158 D-loop; other site 266940004159 H-loop/switch region; other site 266940004160 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 266940004161 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266940004162 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940004163 Walker A/P-loop; other site 266940004164 ATP binding site [chemical binding]; other site 266940004165 Q-loop/lid; other site 266940004166 ABC transporter signature motif; other site 266940004167 Walker B; other site 266940004168 D-loop; other site 266940004169 H-loop/switch region; other site 266940004170 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 266940004171 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940004172 NAD(P) binding site [chemical binding]; other site 266940004173 active site 266940004174 short chain dehydrogenase; Provisional; Region: PRK06197 266940004175 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 266940004176 putative NAD(P) binding site [chemical binding]; other site 266940004177 active site 266940004178 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 266940004179 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 266940004180 active site 266940004181 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 266940004182 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 266940004183 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 266940004184 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 266940004185 active site 266940004186 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 266940004187 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266940004188 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266940004189 DNA binding residues [nucleotide binding] 266940004190 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266940004191 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266940004192 active site 266940004193 phosphorylation site [posttranslational modification] 266940004194 intermolecular recognition site; other site 266940004195 dimerization interface [polypeptide binding]; other site 266940004196 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266940004197 DNA binding residues [nucleotide binding] 266940004198 dimerization interface [polypeptide binding]; other site 266940004199 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 266940004200 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 266940004201 DNA binding residues [nucleotide binding] 266940004202 Transcription factor WhiB; Region: Whib; pfam02467 266940004203 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 266940004204 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 266940004205 ring oligomerisation interface [polypeptide binding]; other site 266940004206 ATP/Mg binding site [chemical binding]; other site 266940004207 stacking interactions; other site 266940004208 hinge regions; other site 266940004209 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 266940004210 oligomerisation interface [polypeptide binding]; other site 266940004211 mobile loop; other site 266940004212 roof hairpin; other site 266940004213 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 266940004214 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940004215 D-galactonate transporter; Region: 2A0114; TIGR00893 266940004216 putative substrate translocation pore; other site 266940004217 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940004218 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 266940004219 Glycoprotease family; Region: Peptidase_M22; pfam00814 266940004220 Esterase/lipase [General function prediction only]; Region: COG1647 266940004221 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 266940004222 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266940004223 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 266940004224 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 266940004225 catalytic site [active] 266940004226 TAP-like protein; Region: Abhydrolase_4; pfam08386 266940004227 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 266940004228 alanine racemase; Reviewed; Region: alr; PRK00053 266940004229 active site 266940004230 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266940004231 dimer interface [polypeptide binding]; other site 266940004232 substrate binding site [chemical binding]; other site 266940004233 catalytic residues [active] 266940004234 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 266940004235 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 266940004236 putative substrate binding site [chemical binding]; other site 266940004237 putative ATP binding site [chemical binding]; other site 266940004238 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 266940004239 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 266940004240 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 266940004241 glutaminase active site [active] 266940004242 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 266940004243 dimer interface [polypeptide binding]; other site 266940004244 active site 266940004245 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 266940004246 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 266940004247 dimer interface [polypeptide binding]; other site 266940004248 active site 266940004249 pantothenate kinase; Provisional; Region: PRK05439 266940004250 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 266940004251 ATP-binding site [chemical binding]; other site 266940004252 CoA-binding site [chemical binding]; other site 266940004253 Mg2+-binding site [ion binding]; other site 266940004254 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 266940004255 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 266940004256 active site 266940004257 substrate binding site [chemical binding]; other site 266940004258 metal binding site [ion binding]; metal-binding site 266940004259 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 266940004260 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 266940004261 23S rRNA interface [nucleotide binding]; other site 266940004262 L3 interface [polypeptide binding]; other site 266940004263 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 266940004264 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940004265 Walker A/P-loop; other site 266940004266 ATP binding site [chemical binding]; other site 266940004267 Q-loop/lid; other site 266940004268 ABC transporter signature motif; other site 266940004269 Walker B; other site 266940004270 D-loop; other site 266940004271 H-loop/switch region; other site 266940004272 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266940004273 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266940004274 catalytic core [active] 266940004275 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 266940004276 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 266940004277 active site 266940004278 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 266940004279 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 266940004280 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 266940004281 alphaNTD - beta interaction site [polypeptide binding]; other site 266940004282 alphaNTD homodimer interface [polypeptide binding]; other site 266940004283 alphaNTD - beta' interaction site [polypeptide binding]; other site 266940004284 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 266940004285 30S ribosomal protein S11; Validated; Region: PRK05309 266940004286 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 266940004287 30S ribosomal protein S13; Region: bact_S13; TIGR03631 266940004288 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 266940004289 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 266940004290 rRNA binding site [nucleotide binding]; other site 266940004291 predicted 30S ribosome binding site; other site 266940004292 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 266940004293 active site 266940004294 adenylate kinase; Reviewed; Region: adk; PRK00279 266940004295 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 266940004296 AMP-binding site [chemical binding]; other site 266940004297 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 266940004298 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 266940004299 SecY translocase; Region: SecY; pfam00344 266940004300 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 266940004301 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 266940004302 23S rRNA binding site [nucleotide binding]; other site 266940004303 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 266940004304 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 266940004305 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 266940004306 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 266940004307 5S rRNA interface [nucleotide binding]; other site 266940004308 23S rRNA interface [nucleotide binding]; other site 266940004309 L5 interface [polypeptide binding]; other site 266940004310 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 266940004311 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 266940004312 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 266940004313 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 266940004314 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 266940004315 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 266940004316 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 266940004317 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 266940004318 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 266940004319 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 266940004320 RNA binding site [nucleotide binding]; other site 266940004321 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 266940004322 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 266940004323 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 266940004324 putative translocon interaction site; other site 266940004325 23S rRNA interface [nucleotide binding]; other site 266940004326 signal recognition particle (SRP54) interaction site; other site 266940004327 L23 interface [polypeptide binding]; other site 266940004328 trigger factor interaction site; other site 266940004329 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 266940004330 23S rRNA interface [nucleotide binding]; other site 266940004331 5S rRNA interface [nucleotide binding]; other site 266940004332 putative antibiotic binding site [chemical binding]; other site 266940004333 L25 interface [polypeptide binding]; other site 266940004334 L27 interface [polypeptide binding]; other site 266940004335 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 266940004336 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 266940004337 G-X-X-G motif; other site 266940004338 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 266940004339 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 266940004340 putative translocon binding site; other site 266940004341 protein-rRNA interface [nucleotide binding]; other site 266940004342 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 266940004343 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 266940004344 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 266940004345 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 266940004346 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 266940004347 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 266940004348 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 266940004349 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 266940004350 elongation factor Tu; Reviewed; Region: PRK00049 266940004351 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 266940004352 G1 box; other site 266940004353 GEF interaction site [polypeptide binding]; other site 266940004354 GTP/Mg2+ binding site [chemical binding]; other site 266940004355 Switch I region; other site 266940004356 G2 box; other site 266940004357 G3 box; other site 266940004358 Switch II region; other site 266940004359 G4 box; other site 266940004360 G5 box; other site 266940004361 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 266940004362 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 266940004363 Antibiotic Binding Site [chemical binding]; other site 266940004364 elongation factor G; Reviewed; Region: PRK00007 266940004365 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 266940004366 G1 box; other site 266940004367 putative GEF interaction site [polypeptide binding]; other site 266940004368 GTP/Mg2+ binding site [chemical binding]; other site 266940004369 Switch I region; other site 266940004370 G2 box; other site 266940004371 G3 box; other site 266940004372 Switch II region; other site 266940004373 G4 box; other site 266940004374 G5 box; other site 266940004375 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 266940004376 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 266940004377 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 266940004378 30S ribosomal protein S7; Validated; Region: PRK05302 266940004379 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 266940004380 S17 interaction site [polypeptide binding]; other site 266940004381 S8 interaction site; other site 266940004382 16S rRNA interaction site [nucleotide binding]; other site 266940004383 streptomycin interaction site [chemical binding]; other site 266940004384 23S rRNA interaction site [nucleotide binding]; other site 266940004385 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 266940004386 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 266940004387 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 266940004388 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 266940004389 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 266940004390 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 266940004391 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 266940004392 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 266940004393 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 266940004394 G-loop; other site 266940004395 DNA binding site [nucleotide binding] 266940004396 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 266940004397 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 266940004398 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 266940004399 RPB10 interaction site [polypeptide binding]; other site 266940004400 RPB1 interaction site [polypeptide binding]; other site 266940004401 RPB11 interaction site [polypeptide binding]; other site 266940004402 RPB3 interaction site [polypeptide binding]; other site 266940004403 RPB12 interaction site [polypeptide binding]; other site 266940004404 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 266940004405 core dimer interface [polypeptide binding]; other site 266940004406 peripheral dimer interface [polypeptide binding]; other site 266940004407 L10 interface [polypeptide binding]; other site 266940004408 L11 interface [polypeptide binding]; other site 266940004409 putative EF-Tu interaction site [polypeptide binding]; other site 266940004410 putative EF-G interaction site [polypeptide binding]; other site 266940004411 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 266940004412 23S rRNA interface [nucleotide binding]; other site 266940004413 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 266940004414 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 266940004415 mRNA/rRNA interface [nucleotide binding]; other site 266940004416 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 266940004417 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 266940004418 23S rRNA interface [nucleotide binding]; other site 266940004419 L7/L12 interface [polypeptide binding]; other site 266940004420 putative thiostrepton binding site; other site 266940004421 L25 interface [polypeptide binding]; other site 266940004422 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 266940004423 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 266940004424 putative homodimer interface [polypeptide binding]; other site 266940004425 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 266940004426 heterodimer interface [polypeptide binding]; other site 266940004427 homodimer interface [polypeptide binding]; other site 266940004428 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 266940004429 aspartate aminotransferase; Provisional; Region: PRK05764 266940004430 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266940004431 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266940004432 homodimer interface [polypeptide binding]; other site 266940004433 catalytic residue [active] 266940004434 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 266940004435 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 266940004436 Walker A/P-loop; other site 266940004437 ATP binding site [chemical binding]; other site 266940004438 Q-loop/lid; other site 266940004439 ABC transporter signature motif; other site 266940004440 Walker B; other site 266940004441 D-loop; other site 266940004442 H-loop/switch region; other site 266940004443 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 266940004444 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 266940004445 adenosine deaminase; Provisional; Region: PRK09358 266940004446 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 266940004447 active site 266940004448 Predicted transcriptional regulators [Transcription]; Region: COG1725 266940004449 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 266940004450 FAD binding domain; Region: FAD_binding_4; pfam01565 266940004451 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 266940004452 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 266940004453 active site 266940004454 catalytic site [active] 266940004455 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 266940004456 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 266940004457 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 266940004458 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 266940004459 heat shock protein HtpX; Provisional; Region: PRK03072 266940004460 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 266940004461 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 266940004462 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 266940004463 Ligand Binding Site [chemical binding]; other site 266940004464 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 266940004465 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 266940004466 Ligand binding site [chemical binding]; other site 266940004467 Electron transfer flavoprotein domain; Region: ETF; pfam01012 266940004468 ferredoxin-NADP+ reductase; Region: PLN02852 266940004469 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266940004470 Predicted permeases [General function prediction only]; Region: RarD; COG2962 266940004471 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 266940004472 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 266940004473 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 266940004474 active site 266940004475 DNA binding site [nucleotide binding] 266940004476 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 266940004477 DNA binding site [nucleotide binding] 266940004478 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 266940004479 nucleotide binding site [chemical binding]; other site 266940004480 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 266940004481 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266940004482 dimerization interface [polypeptide binding]; other site 266940004483 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 266940004484 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266940004485 putative CheW interface [polypeptide binding]; other site 266940004486 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 266940004487 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 266940004488 substrate binding pocket [chemical binding]; other site 266940004489 chain length determination region; other site 266940004490 substrate-Mg2+ binding site; other site 266940004491 catalytic residues [active] 266940004492 aspartate-rich region 1; other site 266940004493 active site lid residues [active] 266940004494 aspartate-rich region 2; other site 266940004495 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 266940004496 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266940004497 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 266940004498 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266940004499 S-adenosylmethionine binding site [chemical binding]; other site 266940004500 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 266940004501 dimer interface [polypeptide binding]; other site 266940004502 tetramer interface [polypeptide binding]; other site 266940004503 PYR/PP interface [polypeptide binding]; other site 266940004504 TPP binding site [chemical binding]; other site 266940004505 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 266940004506 TPP-binding site; other site 266940004507 Predicted integral membrane protein [Function unknown]; Region: COG0392 266940004508 Uncharacterized conserved protein [Function unknown]; Region: COG2898 266940004509 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 266940004510 O-succinylbenzoate synthase; Provisional; Region: PRK02901 266940004511 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 266940004512 active site 266940004513 GAF domain; Region: GAF; pfam01590 266940004514 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 266940004515 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 266940004516 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266940004517 substrate binding site [chemical binding]; other site 266940004518 oxyanion hole (OAH) forming residues; other site 266940004519 trimer interface [polypeptide binding]; other site 266940004520 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940004521 metal binding site [ion binding]; metal-binding site 266940004522 active site 266940004523 I-site; other site 266940004524 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266940004525 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940004526 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940004527 metal binding site [ion binding]; metal-binding site 266940004528 active site 266940004529 I-site; other site 266940004530 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266940004531 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266940004532 active site 266940004533 CoA binding site [chemical binding]; other site 266940004534 AMP binding site [chemical binding]; other site 266940004535 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 266940004536 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 266940004537 UbiA prenyltransferase family; Region: UbiA; pfam01040 266940004538 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 266940004539 active site pocket [active] 266940004540 oxyanion hole [active] 266940004541 catalytic triad [active] 266940004542 active site nucleophile [active] 266940004543 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 266940004544 ResB-like family; Region: ResB; pfam05140 266940004545 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 266940004546 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 266940004547 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 266940004548 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 266940004549 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 266940004550 catalytic residues [active] 266940004551 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266940004552 catalytic core [active] 266940004553 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266940004554 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 266940004555 inhibitor-cofactor binding pocket; inhibition site 266940004556 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266940004557 catalytic residue [active] 266940004558 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266940004559 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 266940004560 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266940004561 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266940004562 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266940004563 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 266940004564 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 266940004565 putative active site [active] 266940004566 putative metal binding site [ion binding]; other site 266940004567 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 266940004568 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 266940004569 active site 266940004570 catalytic residues [active] 266940004571 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 266940004572 dimer interface [polypeptide binding]; other site 266940004573 active site 266940004574 Schiff base residues; other site 266940004575 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 266940004576 active site 266940004577 homodimer interface [polypeptide binding]; other site 266940004578 SAM binding site [chemical binding]; other site 266940004579 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 266940004580 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 266940004581 active site 266940004582 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 266940004583 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 266940004584 domain interfaces; other site 266940004585 active site 266940004586 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 266940004587 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 266940004588 tRNA; other site 266940004589 putative tRNA binding site [nucleotide binding]; other site 266940004590 putative NADP binding site [chemical binding]; other site 266940004591 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 266940004592 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 266940004593 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 266940004594 CoA binding domain; Region: CoA_binding; pfam02629 266940004595 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 266940004596 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 266940004597 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 266940004598 DNA binding domain, excisionase family; Region: excise; TIGR01764 266940004599 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 266940004600 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 266940004601 active site 266940004602 Zn binding site [ion binding]; other site 266940004603 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 266940004604 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 266940004605 exopolyphosphatase; Region: exo_poly_only; TIGR03706 266940004606 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 266940004607 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266940004608 S-adenosylmethionine binding site [chemical binding]; other site 266940004609 PAS domain; Region: PAS_9; pfam13426 266940004610 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266940004611 putative active site [active] 266940004612 heme pocket [chemical binding]; other site 266940004613 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940004614 metal binding site [ion binding]; metal-binding site 266940004615 active site 266940004616 I-site; other site 266940004617 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266940004618 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940004619 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940004620 metal binding site [ion binding]; metal-binding site 266940004621 active site 266940004622 I-site; other site 266940004623 DNA repair protein RadA; Provisional; Region: PRK11823 266940004624 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 266940004625 Walker A motif; other site 266940004626 ATP binding site [chemical binding]; other site 266940004627 Walker B motif; other site 266940004628 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 266940004629 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 266940004630 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 266940004631 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 266940004632 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 266940004633 Domain of unknown function (DUF892); Region: DUF892; pfam05974 266940004634 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 266940004635 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 266940004636 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 266940004637 minor groove reading motif; other site 266940004638 helix-hairpin-helix signature motif; other site 266940004639 active site 266940004640 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 266940004641 hypothetical protein; Provisional; Region: PRK09256 266940004642 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 266940004643 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 266940004644 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266940004645 Coenzyme A binding pocket [chemical binding]; other site 266940004646 Clp protease ATP binding subunit; Region: clpC; CHL00095 266940004647 Clp amino terminal domain; Region: Clp_N; pfam02861 266940004648 Clp amino terminal domain; Region: Clp_N; pfam02861 266940004649 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266940004650 Walker A motif; other site 266940004651 ATP binding site [chemical binding]; other site 266940004652 Walker B motif; other site 266940004653 arginine finger; other site 266940004654 UvrB/uvrC motif; Region: UVR; pfam02151 266940004655 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266940004656 Walker A motif; other site 266940004657 ATP binding site [chemical binding]; other site 266940004658 Walker B motif; other site 266940004659 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 266940004660 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266940004661 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266940004662 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266940004663 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266940004664 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940004665 ABC-ATPase subunit interface; other site 266940004666 putative PBP binding loops; other site 266940004667 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 266940004668 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940004669 putative PBP binding loops; other site 266940004670 ABC-ATPase subunit interface; other site 266940004671 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266940004672 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 266940004673 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266940004674 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266940004675 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 266940004676 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 266940004677 glucuronate isomerase; Reviewed; Region: PRK02925 266940004678 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266940004679 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266940004680 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 266940004681 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266940004682 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266940004683 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 266940004684 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 266940004685 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 266940004686 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 266940004687 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 266940004688 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 266940004689 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266940004690 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266940004691 DNA binding site [nucleotide binding] 266940004692 domain linker motif; other site 266940004693 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 266940004694 dimerization interface [polypeptide binding]; other site 266940004695 ligand binding site [chemical binding]; other site 266940004696 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 266940004697 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940004698 Walker A/P-loop; other site 266940004699 ATP binding site [chemical binding]; other site 266940004700 Q-loop/lid; other site 266940004701 ABC transporter signature motif; other site 266940004702 Walker B; other site 266940004703 D-loop; other site 266940004704 H-loop/switch region; other site 266940004705 Lsr2; Region: Lsr2; pfam11774 266940004706 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 266940004707 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 266940004708 dimer interface [polypeptide binding]; other site 266940004709 putative anticodon binding site; other site 266940004710 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 266940004711 motif 1; other site 266940004712 dimer interface [polypeptide binding]; other site 266940004713 active site 266940004714 motif 2; other site 266940004715 motif 3; other site 266940004716 pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380 266940004717 active site 266940004718 nucleotide binding site [chemical binding]; other site 266940004719 HIGH motif; other site 266940004720 KMSKS motif; other site 266940004721 Rossmann-like domain; Region: Rossmann-like; pfam10727 266940004722 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 266940004723 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 266940004724 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 266940004725 Zn2+ binding site [ion binding]; other site 266940004726 Mg2+ binding site [ion binding]; other site 266940004727 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 266940004728 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266940004729 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 266940004730 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 266940004731 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266940004732 extended (e) SDRs; Region: SDR_e; cd08946 266940004733 NAD(P) binding site [chemical binding]; other site 266940004734 active site 266940004735 substrate binding site [chemical binding]; other site 266940004736 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 266940004737 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 266940004738 substrate binding site; other site 266940004739 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266940004740 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 266940004741 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266940004742 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 266940004743 active site 266940004744 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 266940004745 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266940004746 active site 266940004747 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 266940004748 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 266940004749 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 266940004750 trimer interface [polypeptide binding]; other site 266940004751 active site 266940004752 substrate binding site [chemical binding]; other site 266940004753 CoA binding site [chemical binding]; other site 266940004754 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_11; cd13126 266940004755 hypothetical protein; Provisional; Region: PRK08317 266940004756 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266940004757 S-adenosylmethionine binding site [chemical binding]; other site 266940004758 high affinity sulphate transporter 1; Region: sulP; TIGR00815 266940004759 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 266940004760 Sulfate transporter family; Region: Sulfate_transp; pfam00916 266940004761 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 266940004762 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 266940004763 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 266940004764 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266940004765 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266940004766 DNA-binding site [nucleotide binding]; DNA binding site 266940004767 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 266940004768 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266940004769 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266940004770 DNA binding site [nucleotide binding] 266940004771 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 266940004772 putative ligand binding site [chemical binding]; other site 266940004773 putative dimerization interface [polypeptide binding]; other site 266940004774 Bacterial PH domain; Region: DUF304; pfam03703 266940004775 Bacterial PH domain; Region: DUF304; cl01348 266940004776 Bacterial PH domain; Region: DUF304; pfam03703 266940004777 Bacterial PH domain; Region: DUF304; cl01348 266940004778 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 266940004779 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 266940004780 Walker A/P-loop; other site 266940004781 ATP binding site [chemical binding]; other site 266940004782 Q-loop/lid; other site 266940004783 ABC transporter signature motif; other site 266940004784 Walker B; other site 266940004785 D-loop; other site 266940004786 H-loop/switch region; other site 266940004787 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 266940004788 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266940004789 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 266940004790 putative ADP-binding pocket [chemical binding]; other site 266940004791 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 266940004792 putative catalytic site [active] 266940004793 putative metal binding site [ion binding]; other site 266940004794 putative phosphate binding site [ion binding]; other site 266940004795 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 266940004796 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 266940004797 catalytic center binding site [active] 266940004798 ATP binding site [chemical binding]; other site 266940004799 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 266940004800 homooctamer interface [polypeptide binding]; other site 266940004801 active site 266940004802 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 266940004803 dihydropteroate synthase; Region: DHPS; TIGR01496 266940004804 substrate binding pocket [chemical binding]; other site 266940004805 dimer interface [polypeptide binding]; other site 266940004806 inhibitor binding site; inhibition site 266940004807 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 266940004808 homodecamer interface [polypeptide binding]; other site 266940004809 GTP cyclohydrolase I; Provisional; Region: PLN03044 266940004810 active site 266940004811 putative catalytic site residues [active] 266940004812 zinc binding site [ion binding]; other site 266940004813 GTP-CH-I/GFRP interaction surface; other site 266940004814 FtsH Extracellular; Region: FtsH_ext; pfam06480 266940004815 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 266940004816 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266940004817 Walker A motif; other site 266940004818 ATP binding site [chemical binding]; other site 266940004819 Walker B motif; other site 266940004820 arginine finger; other site 266940004821 Peptidase family M41; Region: Peptidase_M41; pfam01434 266940004822 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266940004823 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 266940004824 DNA-binding site [nucleotide binding]; DNA binding site 266940004825 FCD domain; Region: FCD; pfam07729 266940004826 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 266940004827 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 266940004828 putative active site [active] 266940004829 hypothetical protein; Provisional; Region: PRK05463 266940004830 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 266940004831 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 266940004832 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 266940004833 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 266940004834 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266940004835 ATP-grasp domain; Region: ATP-grasp_4; cl17255 266940004836 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 266940004837 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 266940004838 carboxyltransferase (CT) interaction site; other site 266940004839 biotinylation site [posttranslational modification]; other site 266940004840 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 266940004841 putative active site [active] 266940004842 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266940004843 active site 266940004844 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 266940004845 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 266940004846 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 266940004847 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 266940004848 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 266940004849 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 266940004850 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 266940004851 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 266940004852 dimer interface [polypeptide binding]; other site 266940004853 substrate binding site [chemical binding]; other site 266940004854 metal binding sites [ion binding]; metal-binding site 266940004855 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 266940004856 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 266940004857 DNA binding residues [nucleotide binding] 266940004858 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 266940004859 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940004860 metal binding site [ion binding]; metal-binding site 266940004861 active site 266940004862 I-site; other site 266940004863 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266940004864 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266940004865 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 266940004866 PRC-barrel domain; Region: PRC; pfam05239 266940004867 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 266940004868 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 266940004869 Domain of unknown function DUF20; Region: UPF0118; pfam01594 266940004870 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 266940004871 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266940004872 active site 266940004873 phosphorylation site [posttranslational modification] 266940004874 intermolecular recognition site; other site 266940004875 dimerization interface [polypeptide binding]; other site 266940004876 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 266940004877 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 266940004878 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 266940004879 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266940004880 ATP binding site [chemical binding]; other site 266940004881 Mg2+ binding site [ion binding]; other site 266940004882 G-X-G motif; other site 266940004883 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 266940004884 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 266940004885 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 266940004886 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 266940004887 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 266940004888 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 266940004889 homodimer interface [polypeptide binding]; other site 266940004890 substrate-cofactor binding pocket; other site 266940004891 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266940004892 catalytic residue [active] 266940004893 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 266940004894 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 266940004895 NAD(P) binding site [chemical binding]; other site 266940004896 HAMP domain; Region: HAMP; pfam00672 266940004897 dimerization interface [polypeptide binding]; other site 266940004898 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940004899 metal binding site [ion binding]; metal-binding site 266940004900 active site 266940004901 I-site; other site 266940004902 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266940004903 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266940004904 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 266940004905 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266940004906 S-adenosylmethionine binding site [chemical binding]; other site 266940004907 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266940004908 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266940004909 salt bridge; other site 266940004910 non-specific DNA binding site [nucleotide binding]; other site 266940004911 sequence-specific DNA binding site [nucleotide binding]; other site 266940004912 Cupin domain; Region: Cupin_2; pfam07883 266940004913 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 266940004914 Histidine kinase; Region: HisKA_3; pfam07730 266940004915 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 266940004916 NAD(P) binding site [chemical binding]; other site 266940004917 active site 266940004918 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266940004919 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266940004920 sequence-specific DNA binding site [nucleotide binding]; other site 266940004921 salt bridge; other site 266940004922 Cupin domain; Region: Cupin_2; cl17218 266940004923 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 266940004924 arsenical-resistance protein; Region: acr3; TIGR00832 266940004925 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266940004926 putative DNA binding site [nucleotide binding]; other site 266940004927 putative Zn2+ binding site [ion binding]; other site 266940004928 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 266940004929 Low molecular weight phosphatase family; Region: LMWPc; cl00105 266940004930 active site 266940004931 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 266940004932 Chromate transporter; Region: Chromate_transp; pfam02417 266940004933 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 266940004934 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 266940004935 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 266940004936 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266940004937 Coenzyme A binding pocket [chemical binding]; other site 266940004938 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 266940004939 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266940004940 S-adenosylmethionine binding site [chemical binding]; other site 266940004941 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266940004942 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266940004943 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 266940004944 TAP-like protein; Region: Abhydrolase_4; pfam08386 266940004945 DNA polymerase III subunit delta'; Validated; Region: PRK07940 266940004946 DNA polymerase III subunit delta'; Validated; Region: PRK08485 266940004947 thymidylate kinase; Validated; Region: tmk; PRK00698 266940004948 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 266940004949 TMP-binding site; other site 266940004950 ATP-binding site [chemical binding]; other site 266940004951 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 266940004952 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 266940004953 active site 266940004954 interdomain interaction site; other site 266940004955 putative metal-binding site [ion binding]; other site 266940004956 nucleotide binding site [chemical binding]; other site 266940004957 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 266940004958 domain I; other site 266940004959 phosphate binding site [ion binding]; other site 266940004960 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 266940004961 domain II; other site 266940004962 domain III; other site 266940004963 nucleotide binding site [chemical binding]; other site 266940004964 DNA binding groove [nucleotide binding] 266940004965 catalytic site [active] 266940004966 domain IV; other site 266940004967 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 266940004968 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 266940004969 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 266940004970 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266940004971 S-adenosylmethionine binding site [chemical binding]; other site 266940004972 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 266940004973 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 266940004974 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 266940004975 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 266940004976 anti sigma factor interaction site; other site 266940004977 regulatory phosphorylation site [posttranslational modification]; other site 266940004978 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 266940004979 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266940004980 ATP binding site [chemical binding]; other site 266940004981 putative Mg++ binding site [ion binding]; other site 266940004982 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266940004983 nucleotide binding region [chemical binding]; other site 266940004984 ATP-binding site [chemical binding]; other site 266940004985 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 266940004986 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 266940004987 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 266940004988 Walker A motif; other site 266940004989 ATP binding site [chemical binding]; other site 266940004990 Walker B motif; other site 266940004991 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 266940004992 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 266940004993 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 266940004994 Lsr2; Region: Lsr2; pfam11774 266940004995 Bacterial PH domain; Region: DUF304; pfam03703 266940004996 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266940004997 active site 266940004998 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 266940004999 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 266940005000 nucleoside/Zn binding site; other site 266940005001 dimer interface [polypeptide binding]; other site 266940005002 catalytic motif [active] 266940005003 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 266940005004 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 266940005005 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 266940005006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266940005007 Walker A motif; other site 266940005008 ATP binding site [chemical binding]; other site 266940005009 Walker B motif; other site 266940005010 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 266940005011 recombination protein RecR; Reviewed; Region: recR; PRK00076 266940005012 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 266940005013 RecR protein; Region: RecR; pfam02132 266940005014 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 266940005015 putative active site [active] 266940005016 putative metal-binding site [ion binding]; other site 266940005017 tetramer interface [polypeptide binding]; other site 266940005018 aspartate kinase; Reviewed; Region: PRK06635 266940005019 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 266940005020 putative nucleotide binding site [chemical binding]; other site 266940005021 putative catalytic residues [active] 266940005022 putative Mg ion binding site [ion binding]; other site 266940005023 putative aspartate binding site [chemical binding]; other site 266940005024 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 266940005025 putative allosteric regulatory site; other site 266940005026 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 266940005027 putative allosteric regulatory residue; other site 266940005028 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 266940005029 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 266940005030 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 266940005031 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 266940005032 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266940005033 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266940005034 ligand binding site [chemical binding]; other site 266940005035 flexible hinge region; other site 266940005036 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266940005037 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266940005038 ATP binding site [chemical binding]; other site 266940005039 Mg2+ binding site [ion binding]; other site 266940005040 G-X-G motif; other site 266940005041 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266940005042 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266940005043 active site 266940005044 phosphorylation site [posttranslational modification] 266940005045 intermolecular recognition site; other site 266940005046 dimerization interface [polypeptide binding]; other site 266940005047 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 266940005048 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266940005049 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266940005050 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266940005051 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266940005052 TAP-like protein; Region: Abhydrolase_4; pfam08386 266940005053 Methyltransferase domain; Region: Methyltransf_11; pfam08241 266940005054 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 266940005055 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 266940005056 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940005057 Walker A/P-loop; other site 266940005058 ATP binding site [chemical binding]; other site 266940005059 Q-loop/lid; other site 266940005060 ABC transporter signature motif; other site 266940005061 Walker B; other site 266940005062 D-loop; other site 266940005063 H-loop/switch region; other site 266940005064 ABC transporter; Region: ABC_tran_2; pfam12848 266940005065 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266940005066 MFS transport protein AraJ; Provisional; Region: PRK10091 266940005067 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940005068 putative substrate translocation pore; other site 266940005069 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 266940005070 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266940005071 Coenzyme A binding pocket [chemical binding]; other site 266940005072 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 266940005073 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 266940005074 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 266940005075 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266940005076 Domain of unknown function DUF21; Region: DUF21; pfam01595 266940005077 FOG: CBS domain [General function prediction only]; Region: COG0517 266940005078 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 266940005079 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 266940005080 Domain of unknown function DUF21; Region: DUF21; pfam01595 266940005081 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 266940005082 Transporter associated domain; Region: CorC_HlyC; pfam03471 266940005083 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 266940005084 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 266940005085 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 266940005086 Walker A/P-loop; other site 266940005087 ATP binding site [chemical binding]; other site 266940005088 Q-loop/lid; other site 266940005089 ABC transporter signature motif; other site 266940005090 Walker B; other site 266940005091 D-loop; other site 266940005092 H-loop/switch region; other site 266940005093 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 266940005094 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 266940005095 ABC-ATPase subunit interface; other site 266940005096 dimer interface [polypeptide binding]; other site 266940005097 putative PBP binding regions; other site 266940005098 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 266940005099 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 266940005100 putative ligand binding residues [chemical binding]; other site 266940005101 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266940005102 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266940005103 Walker A/P-loop; other site 266940005104 ATP binding site [chemical binding]; other site 266940005105 Q-loop/lid; other site 266940005106 ABC transporter signature motif; other site 266940005107 Walker B; other site 266940005108 D-loop; other site 266940005109 H-loop/switch region; other site 266940005110 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 266940005111 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266940005112 substrate binding pocket [chemical binding]; other site 266940005113 membrane-bound complex binding site; other site 266940005114 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266940005115 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940005116 dimer interface [polypeptide binding]; other site 266940005117 conserved gate region; other site 266940005118 putative PBP binding loops; other site 266940005119 ABC-ATPase subunit interface; other site 266940005120 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940005121 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940005122 metal binding site [ion binding]; metal-binding site 266940005123 active site 266940005124 I-site; other site 266940005125 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 266940005126 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 266940005127 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 266940005128 DNA binding residues [nucleotide binding] 266940005129 putative dimer interface [polypeptide binding]; other site 266940005130 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266940005131 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266940005132 active site 266940005133 catalytic tetrad [active] 266940005134 PAS domain; Region: PAS; smart00091 266940005135 PAS domain; Region: PAS_9; pfam13426 266940005136 putative active site [active] 266940005137 heme pocket [chemical binding]; other site 266940005138 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 266940005139 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 266940005140 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 266940005141 putative active site [active] 266940005142 putative metal binding site [ion binding]; other site 266940005143 Yqey-like protein; Region: YqeY; pfam09424 266940005144 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 266940005145 Transglycosylase; Region: Transgly; pfam00912 266940005146 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 266940005147 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 266940005148 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 266940005149 Transcription factor WhiB; Region: Whib; pfam02467 266940005150 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 266940005151 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 266940005152 homotrimer interaction site [polypeptide binding]; other site 266940005153 putative active site [active] 266940005154 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266940005155 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 266940005156 ligand binding site [chemical binding]; other site 266940005157 flexible hinge region; other site 266940005158 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 266940005159 putative switch regulator; other site 266940005160 non-specific DNA interactions [nucleotide binding]; other site 266940005161 DNA binding site [nucleotide binding] 266940005162 sequence specific DNA binding site [nucleotide binding]; other site 266940005163 putative cAMP binding site [chemical binding]; other site 266940005164 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 266940005165 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 266940005166 minor groove reading motif; other site 266940005167 helix-hairpin-helix signature motif; other site 266940005168 substrate binding pocket [chemical binding]; other site 266940005169 active site 266940005170 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 266940005171 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 266940005172 putative active site [active] 266940005173 putative CoA binding site [chemical binding]; other site 266940005174 nudix motif; other site 266940005175 metal binding site [ion binding]; metal-binding site 266940005176 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 266940005177 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 266940005178 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 266940005179 Sodium Bile acid symporter family; Region: SBF; pfam01758 266940005180 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 266940005181 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 266940005182 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 266940005183 putative catalytic site [active] 266940005184 putative phosphate binding site [ion binding]; other site 266940005185 putative metal binding site [ion binding]; other site 266940005186 acetyl-CoA synthetase; Provisional; Region: PRK00174 266940005187 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 266940005188 active site 266940005189 CoA binding site [chemical binding]; other site 266940005190 acyl-activating enzyme (AAE) consensus motif; other site 266940005191 AMP binding site [chemical binding]; other site 266940005192 acetate binding site [chemical binding]; other site 266940005193 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266940005194 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266940005195 DNA binding site [nucleotide binding] 266940005196 domain linker motif; other site 266940005197 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 266940005198 dimerization interface [polypeptide binding]; other site 266940005199 ligand binding site [chemical binding]; other site 266940005200 putative alpha-glucosidase; Provisional; Region: PRK10658 266940005201 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 266940005202 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 266940005203 active site 266940005204 homotrimer interface [polypeptide binding]; other site 266940005205 catalytic site [active] 266940005206 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 266940005207 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 266940005208 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 266940005209 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 266940005210 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 266940005211 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266940005212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940005213 dimer interface [polypeptide binding]; other site 266940005214 conserved gate region; other site 266940005215 putative PBP binding loops; other site 266940005216 ABC-ATPase subunit interface; other site 266940005217 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 266940005218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266940005219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940005220 dimer interface [polypeptide binding]; other site 266940005221 ABC-ATPase subunit interface; other site 266940005222 putative PBP binding loops; other site 266940005223 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266940005224 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 266940005225 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 266940005226 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 266940005227 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 266940005228 Domain of unknown function (DUF4394); Region: DUF4394; pfam14339 266940005229 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 266940005230 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266940005231 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266940005232 DNA binding residues [nucleotide binding] 266940005233 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 266940005234 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 266940005235 putative metal binding site [ion binding]; other site 266940005236 UGMP family protein; Validated; Region: PRK09604 266940005237 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 266940005238 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 266940005239 active site 266940005240 catalytic residues [active] 266940005241 metal binding site [ion binding]; metal-binding site 266940005242 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266940005243 PAS domain; Region: PAS_9; pfam13426 266940005244 putative active site [active] 266940005245 heme pocket [chemical binding]; other site 266940005246 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 266940005247 YceI-like domain; Region: YceI; pfam04264 266940005248 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 266940005249 VanW like protein; Region: VanW; pfam04294 266940005250 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266940005251 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266940005252 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940005253 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 266940005254 Walker A/P-loop; other site 266940005255 ATP binding site [chemical binding]; other site 266940005256 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 266940005257 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 266940005258 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 266940005259 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 266940005260 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266940005261 PAS domain; Region: PAS_9; pfam13426 266940005262 putative active site [active] 266940005263 heme pocket [chemical binding]; other site 266940005264 PAS domain S-box; Region: sensory_box; TIGR00229 266940005265 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266940005266 putative active site [active] 266940005267 heme pocket [chemical binding]; other site 266940005268 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940005269 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940005270 metal binding site [ion binding]; metal-binding site 266940005271 active site 266940005272 I-site; other site 266940005273 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 266940005274 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 266940005275 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266940005276 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266940005277 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 266940005278 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266940005279 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266940005280 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 266940005281 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 266940005282 conserved cys residue [active] 266940005283 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266940005284 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940005285 dimer interface [polypeptide binding]; other site 266940005286 conserved gate region; other site 266940005287 ABC-ATPase subunit interface; other site 266940005288 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 266940005289 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940005290 dimer interface [polypeptide binding]; other site 266940005291 conserved gate region; other site 266940005292 putative PBP binding loops; other site 266940005293 ABC-ATPase subunit interface; other site 266940005294 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 266940005295 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266940005296 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266940005297 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266940005298 DNA binding site [nucleotide binding] 266940005299 domain linker motif; other site 266940005300 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 266940005301 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266940005302 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 266940005303 active site 266940005304 catalytic residues [active] 266940005305 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 266940005306 putative ligand binding site [chemical binding]; other site 266940005307 putative NAD binding site [chemical binding]; other site 266940005308 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 266940005309 catalytic site [active] 266940005310 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 266940005311 nucleoside/Zn binding site; other site 266940005312 dimer interface [polypeptide binding]; other site 266940005313 catalytic motif [active] 266940005314 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266940005315 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 266940005316 PAS domain; Region: PAS_9; pfam13426 266940005317 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266940005318 putative active site [active] 266940005319 heme pocket [chemical binding]; other site 266940005320 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 266940005321 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266940005322 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266940005323 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 266940005324 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 266940005325 Prostaglandin dehydrogenases; Region: PGDH; cd05288 266940005326 NAD(P) binding site [chemical binding]; other site 266940005327 substrate binding site [chemical binding]; other site 266940005328 dimer interface [polypeptide binding]; other site 266940005329 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 266940005330 Predicted membrane protein [Function unknown]; Region: COG3463 266940005331 NHL repeat; Region: NHL; pfam01436 266940005332 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 266940005333 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940005334 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940005335 metal binding site [ion binding]; metal-binding site 266940005336 active site 266940005337 I-site; other site 266940005338 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266940005339 Beta-lactamase; Region: Beta-lactamase; pfam00144 266940005340 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 266940005341 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 266940005342 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 266940005343 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 266940005344 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 266940005345 putative dimer interface [polypeptide binding]; other site 266940005346 N-terminal domain interface [polypeptide binding]; other site 266940005347 putative substrate binding pocket (H-site) [chemical binding]; other site 266940005348 Smr domain; Region: Smr; pfam01713 266940005349 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 266940005350 Predicted membrane protein [Function unknown]; Region: COG3463 266940005351 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 266940005352 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 266940005353 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 266940005354 active site 266940005355 catalytic residues [active] 266940005356 LGFP repeat; Region: LGFP; pfam08310 266940005357 LGFP repeat; Region: LGFP; pfam08310 266940005358 LGFP repeat; Region: LGFP; pfam08310 266940005359 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 266940005360 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 266940005361 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 266940005362 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940005363 metal binding site [ion binding]; metal-binding site 266940005364 active site 266940005365 I-site; other site 266940005366 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266940005367 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 266940005368 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 266940005369 putative active site [active] 266940005370 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 266940005371 DNA-binding site [nucleotide binding]; DNA binding site 266940005372 RNA-binding motif; other site 266940005373 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940005374 metal binding site [ion binding]; metal-binding site 266940005375 active site 266940005376 I-site; other site 266940005377 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266940005378 PAS domain; Region: PAS_9; pfam13426 266940005379 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940005380 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940005381 metal binding site [ion binding]; metal-binding site 266940005382 active site 266940005383 I-site; other site 266940005384 OsmC-like protein; Region: OsmC; pfam02566 266940005385 PAS domain; Region: PAS_9; pfam13426 266940005386 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266940005387 putative active site [active] 266940005388 heme pocket [chemical binding]; other site 266940005389 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 266940005390 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 266940005391 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 266940005392 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 266940005393 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 266940005394 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 266940005395 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 266940005396 putative NAD(P) binding site [chemical binding]; other site 266940005397 putative substrate binding site [chemical binding]; other site 266940005398 catalytic Zn binding site [ion binding]; other site 266940005399 structural Zn binding site [ion binding]; other site 266940005400 dimer interface [polypeptide binding]; other site 266940005401 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 266940005402 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266940005403 dimer interface [polypeptide binding]; other site 266940005404 putative CheW interface [polypeptide binding]; other site 266940005405 HTH domain; Region: HTH_11; pfam08279 266940005406 Predicted transcriptional regulator [Transcription]; Region: COG2378 266940005407 WYL domain; Region: WYL; pfam13280 266940005408 Protein of unknown function (DUF664); Region: DUF664; pfam04978 266940005409 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940005410 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940005411 metal binding site [ion binding]; metal-binding site 266940005412 active site 266940005413 I-site; other site 266940005414 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266940005415 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 266940005416 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 266940005417 NAD binding site [chemical binding]; other site 266940005418 ligand binding site [chemical binding]; other site 266940005419 catalytic site [active] 266940005420 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 266940005421 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 266940005422 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 266940005423 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266940005424 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 266940005425 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940005426 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940005427 metal binding site [ion binding]; metal-binding site 266940005428 active site 266940005429 I-site; other site 266940005430 PAS domain; Region: PAS_9; pfam13426 266940005431 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 266940005432 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266940005433 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266940005434 dimer interface [polypeptide binding]; other site 266940005435 phosphorylation site [posttranslational modification] 266940005436 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266940005437 ATP binding site [chemical binding]; other site 266940005438 Mg2+ binding site [ion binding]; other site 266940005439 G-X-G motif; other site 266940005440 Response regulator receiver domain; Region: Response_reg; pfam00072 266940005441 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266940005442 active site 266940005443 phosphorylation site [posttranslational modification] 266940005444 intermolecular recognition site; other site 266940005445 dimerization interface [polypeptide binding]; other site 266940005446 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266940005447 Response regulator receiver domain; Region: Response_reg; pfam00072 266940005448 active site 266940005449 phosphorylation site [posttranslational modification] 266940005450 intermolecular recognition site; other site 266940005451 dimerization interface [polypeptide binding]; other site 266940005452 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 266940005453 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 266940005454 DXD motif; other site 266940005455 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 266940005456 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 266940005457 Ligand binding site; other site 266940005458 Putative Catalytic site; other site 266940005459 DXD motif; other site 266940005460 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 266940005461 dimer interface [polypeptide binding]; other site 266940005462 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266940005463 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266940005464 Response regulator receiver domain; Region: Response_reg; pfam00072 266940005465 active site 266940005466 phosphorylation site [posttranslational modification] 266940005467 intermolecular recognition site; other site 266940005468 dimerization interface [polypeptide binding]; other site 266940005469 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 266940005470 Response regulator receiver domain; Region: Response_reg; pfam00072 266940005471 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266940005472 active site 266940005473 phosphorylation site [posttranslational modification] 266940005474 intermolecular recognition site; other site 266940005475 dimerization interface [polypeptide binding]; other site 266940005476 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 266940005477 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 266940005478 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266940005479 S-adenosylmethionine binding site [chemical binding]; other site 266940005480 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 266940005481 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266940005482 active site 266940005483 phosphorylation site [posttranslational modification] 266940005484 intermolecular recognition site; other site 266940005485 dimerization interface [polypeptide binding]; other site 266940005486 CheB methylesterase; Region: CheB_methylest; pfam01339 266940005487 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 266940005488 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 266940005489 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 266940005490 putative binding surface; other site 266940005491 active site 266940005492 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 266940005493 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 266940005494 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266940005495 ATP binding site [chemical binding]; other site 266940005496 Mg2+ binding site [ion binding]; other site 266940005497 G-X-G motif; other site 266940005498 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 266940005499 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 266940005500 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 266940005501 G1 box; other site 266940005502 GTP/Mg2+ binding site [chemical binding]; other site 266940005503 G2 box; other site 266940005504 Switch I region; other site 266940005505 G3 box; other site 266940005506 Switch II region; other site 266940005507 G4 box; other site 266940005508 G5 box; other site 266940005509 Protein of unknown function (DUF742); Region: DUF742; pfam05331 266940005510 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 266940005511 Nitrate and nitrite sensing; Region: NIT; pfam08376 266940005512 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266940005513 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266940005514 ATP binding site [chemical binding]; other site 266940005515 Mg2+ binding site [ion binding]; other site 266940005516 G-X-G motif; other site 266940005517 MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804 266940005518 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 266940005519 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 266940005520 NAD(P) binding site [chemical binding]; other site 266940005521 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 266940005522 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 266940005523 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 266940005524 putative dimer interface [polypeptide binding]; other site 266940005525 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266940005526 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266940005527 active site 266940005528 catalytic tetrad [active] 266940005529 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 266940005530 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 266940005531 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266940005532 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266940005533 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940005534 ABC-ATPase subunit interface; other site 266940005535 putative PBP binding loops; other site 266940005536 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266940005537 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940005538 dimer interface [polypeptide binding]; other site 266940005539 conserved gate region; other site 266940005540 putative PBP binding loops; other site 266940005541 ABC-ATPase subunit interface; other site 266940005542 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 266940005543 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 266940005544 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 266940005545 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 266940005546 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 266940005547 dimer interface [polypeptide binding]; other site 266940005548 motif 1; other site 266940005549 active site 266940005550 motif 2; other site 266940005551 motif 3; other site 266940005552 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 266940005553 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 266940005554 active site 266940005555 catalytic site [active] 266940005556 metal binding site [ion binding]; metal-binding site 266940005557 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266940005558 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 266940005559 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266940005560 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940005561 dimer interface [polypeptide binding]; other site 266940005562 conserved gate region; other site 266940005563 putative PBP binding loops; other site 266940005564 ABC-ATPase subunit interface; other site 266940005565 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266940005566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940005567 putative PBP binding loops; other site 266940005568 dimer interface [polypeptide binding]; other site 266940005569 ABC-ATPase subunit interface; other site 266940005570 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 266940005571 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 266940005572 putative DNA binding site [nucleotide binding]; other site 266940005573 catalytic residue [active] 266940005574 putative H2TH interface [polypeptide binding]; other site 266940005575 putative catalytic residues [active] 266940005576 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 266940005577 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 266940005578 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 266940005579 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 266940005580 YibE/F-like protein; Region: YibE_F; pfam07907 266940005581 multidrug resistance protein MdtH; Provisional; Region: PRK11646 266940005582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940005583 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 266940005584 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266940005585 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266940005586 active site 266940005587 motif I; other site 266940005588 motif II; other site 266940005589 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 266940005590 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 266940005591 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 266940005592 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 266940005593 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 266940005594 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 266940005595 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 266940005596 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940005597 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940005598 metal binding site [ion binding]; metal-binding site 266940005599 active site 266940005600 I-site; other site 266940005601 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 266940005602 active site 266940005603 catalytic residues [active] 266940005604 PspC domain; Region: PspC; pfam04024 266940005605 PspC domain; Region: PspC; pfam04024 266940005606 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 266940005607 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266940005608 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266940005609 active site 266940005610 phosphorylation site [posttranslational modification] 266940005611 intermolecular recognition site; other site 266940005612 dimerization interface [polypeptide binding]; other site 266940005613 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266940005614 DNA binding residues [nucleotide binding] 266940005615 dimerization interface [polypeptide binding]; other site 266940005616 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266940005617 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266940005618 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 266940005619 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 266940005620 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940005621 putative substrate translocation pore; other site 266940005622 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940005623 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 266940005624 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266940005625 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 266940005626 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 266940005627 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 266940005628 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 266940005629 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 266940005630 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940005631 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266940005632 putative substrate translocation pore; other site 266940005633 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266940005634 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 266940005635 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 266940005636 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 266940005637 NAD binding site [chemical binding]; other site 266940005638 sugar binding site [chemical binding]; other site 266940005639 divalent metal binding site [ion binding]; other site 266940005640 tetramer (dimer of dimers) interface [polypeptide binding]; other site 266940005641 dimer interface [polypeptide binding]; other site 266940005642 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 266940005643 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 266940005644 putative metal binding site [ion binding]; other site 266940005645 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 266940005646 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 266940005647 short chain dehydrogenase; Provisional; Region: PRK06180 266940005648 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 266940005649 NADP binding site [chemical binding]; other site 266940005650 active site 266940005651 steroid binding site; other site 266940005652 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266940005653 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266940005654 active site 266940005655 catalytic tetrad [active] 266940005656 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 266940005657 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 266940005658 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266940005659 active site 266940005660 motif I; other site 266940005661 motif II; other site 266940005662 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 266940005663 Methyltransferase domain; Region: Methyltransf_23; pfam13489 266940005664 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266940005665 S-adenosylmethionine binding site [chemical binding]; other site 266940005666 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 266940005667 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266940005668 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 266940005669 seryl-tRNA synthetase; Provisional; Region: PRK05431 266940005670 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 266940005671 motif 1; other site 266940005672 dimer interface [polypeptide binding]; other site 266940005673 active site 266940005674 motif 2; other site 266940005675 motif 3; other site 266940005676 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 266940005677 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 266940005678 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940005679 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940005680 metal binding site [ion binding]; metal-binding site 266940005681 active site 266940005682 I-site; other site 266940005683 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940005684 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940005685 metal binding site [ion binding]; metal-binding site 266940005686 active site 266940005687 I-site; other site 266940005688 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266940005689 GAF domain; Region: GAF; pfam01590 266940005690 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 266940005691 prephenate dehydratase; Provisional; Region: PRK11898 266940005692 Prephenate dehydratase; Region: PDT; pfam00800 266940005693 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 266940005694 putative L-Phe binding site [chemical binding]; other site 266940005695 Transcription factor WhiB; Region: Whib; pfam02467 266940005696 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 266940005697 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 266940005698 amino acid transporter; Region: 2A0306; TIGR00909 266940005699 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 266940005700 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 266940005701 intersubunit interface [polypeptide binding]; other site 266940005702 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 266940005703 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 266940005704 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 266940005705 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 266940005706 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940005707 metal binding site [ion binding]; metal-binding site 266940005708 active site 266940005709 I-site; other site 266940005710 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266940005711 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 266940005712 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 266940005713 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 266940005714 CHASE3 domain; Region: CHASE3; pfam05227 266940005715 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266940005716 dimerization interface [polypeptide binding]; other site 266940005717 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 266940005718 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 266940005719 FAD binding pocket [chemical binding]; other site 266940005720 conserved FAD binding motif [chemical binding]; other site 266940005721 phosphate binding motif [ion binding]; other site 266940005722 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266940005723 classical (c) SDRs; Region: SDR_c; cd05233 266940005724 NAD(P) binding site [chemical binding]; other site 266940005725 active site 266940005726 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 266940005727 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266940005728 motif II; other site 266940005729 PAS fold; Region: PAS_4; pfam08448 266940005730 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 266940005731 GAF domain; Region: GAF; cl17456 266940005732 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 266940005733 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 266940005734 Fatty acid desaturase; Region: FA_desaturase; pfam00487 266940005735 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 266940005736 putative di-iron ligands [ion binding]; other site 266940005737 GAF domain; Region: GAF; cl17456 266940005738 GAF domain; Region: GAF; pfam01590 266940005739 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 266940005740 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 266940005741 active site residue [active] 266940005742 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266940005743 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266940005744 dimerization interface [polypeptide binding]; other site 266940005745 putative DNA binding site [nucleotide binding]; other site 266940005746 putative Zn2+ binding site [ion binding]; other site 266940005747 AsnC family; Region: AsnC_trans_reg; pfam01037 266940005748 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 266940005749 oligosaccharide amylase; Region: oligosac_amyl; TIGR01577 266940005750 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 266940005751 DNA-binding site [nucleotide binding]; DNA binding site 266940005752 RNA-binding motif; other site 266940005753 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 266940005754 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 266940005755 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 266940005756 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 266940005757 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 266940005758 putative active site; other site 266940005759 putative metal binding residues [ion binding]; other site 266940005760 putative triphosphate binding site [ion binding]; other site 266940005761 signature motif; other site 266940005762 CHAD domain; Region: CHAD; pfam05235 266940005763 Methyltransferase domain; Region: Methyltransf_31; pfam13847 266940005764 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266940005765 S-adenosylmethionine binding site [chemical binding]; other site 266940005766 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 266940005767 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266940005768 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266940005769 DNA binding residues [nucleotide binding] 266940005770 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 266940005771 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 266940005772 DNA binding residues [nucleotide binding] 266940005773 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266940005774 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940005775 NAD(P) binding site [chemical binding]; other site 266940005776 active site 266940005777 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 266940005778 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 266940005779 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 266940005780 AzlC protein; Region: AzlC; pfam03591 266940005781 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 266940005782 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 266940005783 oligomer interface [polypeptide binding]; other site 266940005784 metal binding site [ion binding]; metal-binding site 266940005785 metal binding site [ion binding]; metal-binding site 266940005786 putative Cl binding site [ion binding]; other site 266940005787 basic sphincter; other site 266940005788 hydrophobic gate; other site 266940005789 periplasmic entrance; other site 266940005790 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 266940005791 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 266940005792 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266940005793 substrate binding site [chemical binding]; other site 266940005794 ATP binding site [chemical binding]; other site 266940005795 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 266940005796 active site 266940005797 intersubunit interface [polypeptide binding]; other site 266940005798 catalytic residue [active] 266940005799 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940005800 NAD(P) binding site [chemical binding]; other site 266940005801 active site 266940005802 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 266940005803 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 266940005804 ligand binding site [chemical binding]; other site 266940005805 NAD binding site [chemical binding]; other site 266940005806 catalytic site [active] 266940005807 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266940005808 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 266940005809 Bacterial transcriptional regulator; Region: IclR; pfam01614 266940005810 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 266940005811 DctM-like transporters; Region: DctM; pfam06808 266940005812 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 266940005813 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 266940005814 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 266940005815 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 266940005816 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 266940005817 CrcB-like protein; Region: CRCB; cl09114 266940005818 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 266940005819 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 266940005820 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 266940005821 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266940005822 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266940005823 DNA-binding site [nucleotide binding]; DNA binding site 266940005824 FCD domain; Region: FCD; pfam07729 266940005825 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940005826 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266940005827 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 266940005828 putative hydrophobic ligand binding site [chemical binding]; other site 266940005829 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 266940005830 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 266940005831 dimer interface [polypeptide binding]; other site 266940005832 PYR/PP interface [polypeptide binding]; other site 266940005833 TPP binding site [chemical binding]; other site 266940005834 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266940005835 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 266940005836 TPP-binding site [chemical binding]; other site 266940005837 dimer interface [polypeptide binding]; other site 266940005838 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266940005839 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 266940005840 putative DNA binding site [nucleotide binding]; other site 266940005841 putative Zn2+ binding site [ion binding]; other site 266940005842 AsnC family; Region: AsnC_trans_reg; pfam01037 266940005843 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 266940005844 dimer interface [polypeptide binding]; other site 266940005845 Alkaline phosphatase homologues; Region: alkPPc; smart00098 266940005846 active site 266940005847 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 266940005848 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940005849 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940005850 active site 266940005851 I-site; other site 266940005852 metal binding site [ion binding]; metal-binding site 266940005853 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 266940005854 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266940005855 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940005856 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940005857 metal binding site [ion binding]; metal-binding site 266940005858 active site 266940005859 I-site; other site 266940005860 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266940005861 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266940005862 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266940005863 active site 266940005864 catalytic tetrad [active] 266940005865 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 266940005866 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266940005867 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266940005868 catalytic residue [active] 266940005869 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266940005870 ATP binding site [chemical binding]; other site 266940005871 putative Mg++ binding site [ion binding]; other site 266940005872 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266940005873 nucleotide binding region [chemical binding]; other site 266940005874 ATP-binding site [chemical binding]; other site 266940005875 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 266940005876 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266940005877 DNA binding residues [nucleotide binding] 266940005878 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 266940005879 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 266940005880 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 266940005881 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 266940005882 PAS fold; Region: PAS_3; pfam08447 266940005883 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 266940005884 heme pocket [chemical binding]; other site 266940005885 putative active site [active] 266940005886 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 266940005887 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 266940005888 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 266940005889 ATP binding site [chemical binding]; other site 266940005890 Mg2+ binding site [ion binding]; other site 266940005891 G-X-G motif; other site 266940005892 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 266940005893 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 266940005894 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 266940005895 active site residue [active] 266940005896 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 266940005897 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 266940005898 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266940005899 active site 266940005900 Part of AAA domain; Region: AAA_19; pfam13245 266940005901 Ferritin-like domain; Region: Ferritin_2; pfam13668 266940005902 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 266940005903 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 266940005904 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266940005905 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266940005906 catalytic residue [active] 266940005907 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 266940005908 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 266940005909 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 266940005910 putative DNA binding site [nucleotide binding]; other site 266940005911 catalytic residue [active] 266940005912 putative H2TH interface [polypeptide binding]; other site 266940005913 putative catalytic residues [active] 266940005914 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 266940005915 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 266940005916 Predicted membrane protein [Function unknown]; Region: COG2119 266940005917 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 266940005918 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 266940005919 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 266940005920 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 266940005921 ATP binding site [chemical binding]; other site 266940005922 Mg2+ binding site [ion binding]; other site 266940005923 G-X-G motif; other site 266940005924 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 266940005925 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 266940005926 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 266940005927 FMN binding site [chemical binding]; other site 266940005928 active site 266940005929 substrate binding site [chemical binding]; other site 266940005930 catalytic residue [active] 266940005931 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 266940005932 N-terminal domain of the plant and fungal Nei and related proteins; Region: PF_Nei_N; cd08972 266940005933 putative DNA binding site [nucleotide binding]; other site 266940005934 catalytic residue [active] 266940005935 putative H2TH interface [polypeptide binding]; other site 266940005936 putative catalytic residues [active] 266940005937 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 266940005938 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266940005939 DNA-binding site [nucleotide binding]; DNA binding site 266940005940 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 266940005941 FCD domain; Region: FCD; pfam07729 266940005942 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 266940005943 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266940005944 Walker A/P-loop; other site 266940005945 ATP binding site [chemical binding]; other site 266940005946 Q-loop/lid; other site 266940005947 ABC transporter signature motif; other site 266940005948 Walker B; other site 266940005949 D-loop; other site 266940005950 H-loop/switch region; other site 266940005951 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266940005952 Walker A/P-loop; other site 266940005953 ATP binding site [chemical binding]; other site 266940005954 Q-loop/lid; other site 266940005955 ABC transporter signature motif; other site 266940005956 Walker B; other site 266940005957 D-loop; other site 266940005958 H-loop/switch region; other site 266940005959 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266940005960 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 266940005961 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 266940005962 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 266940005963 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940005964 putative PBP binding loops; other site 266940005965 dimer interface [polypeptide binding]; other site 266940005966 ABC-ATPase subunit interface; other site 266940005967 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266940005968 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940005969 dimer interface [polypeptide binding]; other site 266940005970 conserved gate region; other site 266940005971 ABC-ATPase subunit interface; other site 266940005972 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266940005973 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_5; cd08511 266940005974 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 266940005975 phosphoglucomutase; Validated; Region: PRK07564 266940005976 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 266940005977 active site 266940005978 substrate binding site [chemical binding]; other site 266940005979 metal binding site [ion binding]; metal-binding site 266940005980 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266940005981 RNA binding surface [nucleotide binding]; other site 266940005982 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 266940005983 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 266940005984 DNA binding residues [nucleotide binding] 266940005985 putative dimer interface [polypeptide binding]; other site 266940005986 short chain dehydrogenase; Validated; Region: PRK08264 266940005987 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940005988 NAD(P) binding site [chemical binding]; other site 266940005989 active site 266940005990 PhoD-like phosphatase; Region: PhoD; pfam09423 266940005991 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 266940005992 putative active site [active] 266940005993 putative metal binding site [ion binding]; other site 266940005994 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 266940005995 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940005996 NAD(P) binding site [chemical binding]; other site 266940005997 active site 266940005998 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266940005999 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266940006000 WHG domain; Region: WHG; pfam13305 266940006001 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266940006002 active site 266940006003 catalytic tetrad [active] 266940006004 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854 266940006005 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 266940006006 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 266940006007 PspC domain; Region: PspC; pfam04024 266940006008 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 266940006009 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 266940006010 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266940006011 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266940006012 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 266940006013 putative dimerization interface [polypeptide binding]; other site 266940006014 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266940006015 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266940006016 3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605 266940006017 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266940006018 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266940006019 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 266940006020 catalytic motif [active] 266940006021 Zn binding site [ion binding]; other site 266940006022 RibD C-terminal domain; Region: RibD_C; pfam01872 266940006023 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 266940006024 dimerization interface [polypeptide binding]; other site 266940006025 active site 266940006026 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 266940006027 putative catalytic site [active] 266940006028 putative metal binding site [ion binding]; other site 266940006029 putative phosphate binding site [ion binding]; other site 266940006030 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 266940006031 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 266940006032 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 266940006033 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 266940006034 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 266940006035 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 266940006036 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266940006037 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940006038 dimer interface [polypeptide binding]; other site 266940006039 conserved gate region; other site 266940006040 ABC-ATPase subunit interface; other site 266940006041 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940006042 dimer interface [polypeptide binding]; other site 266940006043 conserved gate region; other site 266940006044 putative PBP binding loops; other site 266940006045 ABC-ATPase subunit interface; other site 266940006046 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266940006047 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266940006048 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266940006049 DNA binding site [nucleotide binding] 266940006050 domain linker motif; other site 266940006051 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266940006052 DNA binding site [nucleotide binding] 266940006053 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266940006054 domain linker motif; other site 266940006055 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 266940006056 dimerization interface [polypeptide binding]; other site 266940006057 ligand binding site [chemical binding]; other site 266940006058 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 266940006059 nudix motif; other site 266940006060 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 266940006061 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 266940006062 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 266940006063 CutC family; Region: CutC; cl01218 266940006064 L-asparaginase II; Region: Asparaginase_II; pfam06089 266940006065 citrate synthase; Provisional; Region: PRK14033 266940006066 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 266940006067 oxalacetate binding site [chemical binding]; other site 266940006068 citrylCoA binding site [chemical binding]; other site 266940006069 coenzyme A binding site [chemical binding]; other site 266940006070 catalytic triad [active] 266940006071 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 266940006072 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 266940006073 tetramer interface [polypeptide binding]; other site 266940006074 active site 266940006075 Mg2+/Mn2+ binding site [ion binding]; other site 266940006076 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 266940006077 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266940006078 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266940006079 DNA-binding site [nucleotide binding]; DNA binding site 266940006080 FCD domain; Region: FCD; pfam07729 266940006081 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 266940006082 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 266940006083 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 266940006084 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 266940006085 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 266940006086 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266940006087 DNA binding residues [nucleotide binding] 266940006088 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940006089 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940006090 metal binding site [ion binding]; metal-binding site 266940006091 active site 266940006092 I-site; other site 266940006093 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266940006094 PAS fold; Region: PAS_3; pfam08447 266940006095 putative active site [active] 266940006096 heme pocket [chemical binding]; other site 266940006097 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266940006098 PAS domain; Region: PAS_9; pfam13426 266940006099 putative active site [active] 266940006100 heme pocket [chemical binding]; other site 266940006101 GAF domain; Region: GAF_2; pfam13185 266940006102 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 266940006103 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 266940006104 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 266940006105 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 266940006106 Mg2+ binding site [ion binding]; other site 266940006107 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 266940006108 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 266940006109 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 266940006110 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266940006111 Coenzyme A binding pocket [chemical binding]; other site 266940006112 YceI-like domain; Region: YceI; smart00867 266940006113 Lycopene cyclase protein; Region: Lycopene_cycl; pfam05834 266940006114 lycopene cyclase; Region: lycopene_cycl; TIGR01789 266940006115 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 266940006116 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 266940006117 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940006118 metal binding site [ion binding]; metal-binding site 266940006119 active site 266940006120 I-site; other site 266940006121 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266940006122 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 266940006123 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940006124 ATP binding site [chemical binding]; other site 266940006125 Q-loop/lid; other site 266940006126 ABC transporter signature motif; other site 266940006127 Walker B; other site 266940006128 D-loop; other site 266940006129 H-loop/switch region; other site 266940006130 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940006131 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 266940006132 NAD(P) binding site [chemical binding]; other site 266940006133 active site 266940006134 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 266940006135 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266940006136 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 266940006137 homotrimer interaction site [polypeptide binding]; other site 266940006138 putative active site [active] 266940006139 glycogen branching enzyme; Provisional; Region: PRK14705 266940006140 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 266940006141 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 266940006142 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266940006143 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266940006144 DNA binding residues [nucleotide binding] 266940006145 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 266940006146 conserved cys residue [active] 266940006147 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 266940006148 substrate binding site [chemical binding]; other site 266940006149 active site 266940006150 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 266940006151 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 266940006152 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 266940006153 phosphopeptide binding site; other site 266940006154 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 266940006155 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 266940006156 phosphopeptide binding site; other site 266940006157 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 266940006158 Protein phosphatase 2C; Region: PP2C; pfam00481 266940006159 active site 266940006160 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 266940006161 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 266940006162 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 266940006163 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266940006164 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 266940006165 active site 266940006166 ATP binding site [chemical binding]; other site 266940006167 substrate binding site [chemical binding]; other site 266940006168 activation loop (A-loop); other site 266940006169 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 266940006170 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 266940006171 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 266940006172 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 266940006173 active site 266940006174 metal binding site [ion binding]; metal-binding site 266940006175 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266940006176 Ligand Binding Site [chemical binding]; other site 266940006177 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 266940006178 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 266940006179 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266940006180 sensory histidine kinase DcuS; Provisional; Region: PRK11086 266940006181 PAS domain; Region: PAS; smart00091 266940006182 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 266940006183 ATP binding site [chemical binding]; other site 266940006184 G-X-G motif; other site 266940006185 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 266940006186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266940006187 active site 266940006188 phosphorylation site [posttranslational modification] 266940006189 intermolecular recognition site; other site 266940006190 dimerization interface [polypeptide binding]; other site 266940006191 Helix-turn-helix domain; Region: HTH_20; pfam12840 266940006192 SpoOM protein; Region: Spo0M; pfam07070 266940006193 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 266940006194 threonine dehydratase; Provisional; Region: PRK08246 266940006195 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 266940006196 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266940006197 catalytic residue [active] 266940006198 oxidoreductase; Provisional; Region: PRK06128 266940006199 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 266940006200 NAD binding site [chemical binding]; other site 266940006201 metal binding site [ion binding]; metal-binding site 266940006202 active site 266940006203 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 266940006204 LGFP repeat; Region: LGFP; pfam08310 266940006205 LGFP repeat; Region: LGFP; pfam08310 266940006206 LGFP repeat; Region: LGFP; pfam08310 266940006207 LGFP repeat; Region: LGFP; pfam08310 266940006208 LGFP repeat; Region: LGFP; pfam08310 266940006209 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 266940006210 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 266940006211 active site 266940006212 homotetramer interface [polypeptide binding]; other site 266940006213 homodimer interface [polypeptide binding]; other site 266940006214 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 266940006215 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940006216 Walker A/P-loop; other site 266940006217 ATP binding site [chemical binding]; other site 266940006218 Q-loop/lid; other site 266940006219 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 266940006220 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940006221 Walker A/P-loop; other site 266940006222 ATP binding site [chemical binding]; other site 266940006223 Q-loop/lid; other site 266940006224 ABC transporter signature motif; other site 266940006225 Walker B; other site 266940006226 D-loop; other site 266940006227 H-loop/switch region; other site 266940006228 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 266940006229 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266940006230 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266940006231 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 266940006232 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 266940006233 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266940006234 dimerization interface [polypeptide binding]; other site 266940006235 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266940006236 dimer interface [polypeptide binding]; other site 266940006237 putative CheW interface [polypeptide binding]; other site 266940006238 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 266940006239 Excalibur calcium-binding domain; Region: Excalibur; smart00894 266940006240 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 266940006241 DNA binding residues [nucleotide binding] 266940006242 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 266940006243 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 266940006244 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 266940006245 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 266940006246 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 266940006247 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 266940006248 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 266940006249 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 266940006250 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 266940006251 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 266940006252 LGFP repeat; Region: LGFP; pfam08310 266940006253 LGFP repeat; Region: LGFP; pfam08310 266940006254 LGFP repeat; Region: LGFP; pfam08310 266940006255 LGFP repeat; Region: LGFP; pfam08310 266940006256 Protein of unknown function (DUF429); Region: DUF429; cl12046 266940006257 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940006258 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940006259 metal binding site [ion binding]; metal-binding site 266940006260 active site 266940006261 I-site; other site 266940006262 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 266940006263 hypothetical protein; Provisional; Region: PRK04233 266940006264 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266940006265 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266940006266 DNA binding site [nucleotide binding] 266940006267 domain linker motif; other site 266940006268 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 266940006269 ligand binding site [chemical binding]; other site 266940006270 dimerization interface [polypeptide binding]; other site 266940006271 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266940006272 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266940006273 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 266940006274 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 266940006275 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 266940006276 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 266940006277 active site 266940006278 catalytic site [active] 266940006279 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 266940006280 Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781 266940006281 B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; Region: BBOX; cl00034 266940006282 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 266940006283 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 266940006284 active site 266940006285 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 266940006286 putative ADP-binding pocket [chemical binding]; other site 266940006287 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266940006288 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_7; cd05844 266940006289 putative ADP-binding pocket [chemical binding]; other site 266940006290 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 266940006291 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266940006292 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 266940006293 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 266940006294 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 266940006295 Bacterial sugar transferase; Region: Bac_transf; pfam02397 266940006296 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 266940006297 Chain length determinant protein; Region: Wzz; cl15801 266940006298 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 266940006299 Low molecular weight phosphatase family; Region: LMWPc; cl00105 266940006300 active site 266940006301 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266940006302 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 266940006303 Walker A motif; other site 266940006304 ATP binding site [chemical binding]; other site 266940006305 Walker B motif; other site 266940006306 arginine finger; other site 266940006307 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 266940006308 DNA gyrase subunit A; Validated; Region: PRK05560 266940006309 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 266940006310 CAP-like domain; other site 266940006311 active site 266940006312 primary dimer interface [polypeptide binding]; other site 266940006313 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266940006314 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266940006315 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266940006316 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266940006317 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266940006318 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266940006319 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 266940006320 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266940006321 Mg2+ binding site [ion binding]; other site 266940006322 G-X-G motif; other site 266940006323 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 266940006324 anchoring element; other site 266940006325 dimer interface [polypeptide binding]; other site 266940006326 ATP binding site [chemical binding]; other site 266940006327 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 266940006328 active site 266940006329 putative metal-binding site [ion binding]; other site 266940006330 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 266940006331 Protein of unknown function (DUF721); Region: DUF721; cl02324 266940006332 recombination protein F; Reviewed; Region: recF; PRK00064 266940006333 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 266940006334 Walker A/P-loop; other site 266940006335 ATP binding site [chemical binding]; other site 266940006336 Q-loop/lid; other site 266940006337 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940006338 ABC transporter signature motif; other site 266940006339 Walker B; other site 266940006340 D-loop; other site 266940006341 H-loop/switch region; other site 266940006342 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 266940006343 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 266940006344 DNA polymerase III subunit beta; Validated; Region: PRK07761 266940006345 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 266940006346 putative DNA binding surface [nucleotide binding]; other site 266940006347 dimer interface [polypeptide binding]; other site 266940006348 beta-clamp/clamp loader binding surface; other site 266940006349 beta-clamp/translesion DNA polymerase binding surface; other site 266940006350 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266940006351 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 266940006352 Walker A motif; other site 266940006353 ATP binding site [chemical binding]; other site 266940006354 Walker B motif; other site 266940006355 arginine finger; other site 266940006356 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 266940006357 DnaA box-binding interface [nucleotide binding]; other site 266940006358 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 266940006359 Ribonuclease P; Region: Ribonuclease_P; cl00457 266940006360 Haemolytic domain; Region: Haemolytic; pfam01809 266940006361 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 266940006362 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 266940006363 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 266940006364 G-X-X-G motif; other site 266940006365 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 266940006366 RxxxH motif; other site 266940006367 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 266940006368 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 266940006369 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 266940006370 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 266940006371 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266940006372 Magnesium ion binding site [ion binding]; other site 266940006373 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 266940006374 ParB-like nuclease domain; Region: ParBc; pfam02195 266940006375 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 266940006376 Coenzyme A binding pocket [chemical binding]; other site 266940006377 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 266940006378 catalytic residues [active] 266940006379 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 266940006380 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266940006381 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266940006382 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 266940006383 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266940006384 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266940006385 DNA binding residues [nucleotide binding] 266940006386 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 266940006387 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 266940006388 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 266940006389 NlpC/P60 family; Region: NLPC_P60; pfam00877 266940006390 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 266940006391 MviN-like protein; Region: MVIN; pfam03023 266940006392 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 266940006393 active site 266940006394 Ap6A binding site [chemical binding]; other site 266940006395 nudix motif; other site 266940006396 metal binding site [ion binding]; metal-binding site 266940006397 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 266940006398 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 266940006399 active site 266940006400 NTP binding site [chemical binding]; other site 266940006401 metal binding triad [ion binding]; metal-binding site 266940006402 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 266940006403 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 266940006404 Zn2+ binding site [ion binding]; other site 266940006405 Mg2+ binding site [ion binding]; other site 266940006406 GAF domain; Region: GAF; cl17456 266940006407 ChaB; Region: ChaB; pfam06150 266940006408 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940006409 putative substrate translocation pore; other site 266940006410 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266940006411 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266940006412 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 266940006413 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266940006414 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940006415 Walker A/P-loop; other site 266940006416 ATP binding site [chemical binding]; other site 266940006417 Q-loop/lid; other site 266940006418 ABC transporter signature motif; other site 266940006419 Walker B; other site 266940006420 D-loop; other site 266940006421 H-loop/switch region; other site 266940006422 MarR family; Region: MarR; pfam01047 266940006423 PAS domain; Region: PAS_9; pfam13426 266940006424 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 266940006425 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 266940006426 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 266940006427 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 266940006428 Proline dehydrogenase; Region: Pro_dh; cl03282 266940006429 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 266940006430 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 266940006431 NAD(P) binding site [chemical binding]; other site 266940006432 catalytic residues [active] 266940006433 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 266940006434 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 266940006435 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 266940006436 PAS fold; Region: PAS_4; pfam08448 266940006437 GAF domain; Region: GAF_2; pfam13185 266940006438 GAF domain; Region: GAF_3; pfam13492 266940006439 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 266940006440 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 266940006441 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 266940006442 ANTAR domain; Region: ANTAR; pfam03861 266940006443 Asp23 family; Region: Asp23; cl00574 266940006444 Asp23 family; Region: Asp23; pfam03780 266940006445 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 266940006446 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266940006447 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266940006448 DNA binding residues [nucleotide binding] 266940006449 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 266940006450 MarR family; Region: MarR; pfam01047 266940006451 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 266940006452 GAF domain; Region: GAF_2; pfam13185 266940006453 GAF domain; Region: GAF_2; pfam13185 266940006454 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 266940006455 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266940006456 dimer interface [polypeptide binding]; other site 266940006457 putative CheW interface [polypeptide binding]; other site 266940006458 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940006459 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940006460 metal binding site [ion binding]; metal-binding site 266940006461 active site 266940006462 I-site; other site 266940006463 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266940006464 PAS fold; Region: PAS; pfam00989 266940006465 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266940006466 putative active site [active] 266940006467 heme pocket [chemical binding]; other site 266940006468 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940006469 metal binding site [ion binding]; metal-binding site 266940006470 active site 266940006471 I-site; other site 266940006472 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266940006473 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 266940006474 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 266940006475 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266940006476 FeS/SAM binding site; other site 266940006477 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 266940006478 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 266940006479 putative NAD(P) binding site [chemical binding]; other site 266940006480 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266940006481 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 266940006482 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266940006483 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 266940006484 putative dimer interface [polypeptide binding]; other site 266940006485 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266940006486 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266940006487 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 266940006488 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266940006489 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 266940006490 Bacterial transcriptional regulator; Region: IclR; pfam01614 266940006491 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 266940006492 active sites [active] 266940006493 tetramer interface [polypeptide binding]; other site 266940006494 urocanate hydratase; Provisional; Region: PRK05414 266940006495 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 266940006496 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266940006497 active site 266940006498 imidazolonepropionase; Provisional; Region: PRK14085 266940006499 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266940006500 active site 266940006501 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 266940006502 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 266940006503 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266940006504 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 266940006505 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266940006506 dimer interface [polypeptide binding]; other site 266940006507 putative CheW interface [polypeptide binding]; other site 266940006508 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 266940006509 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 266940006510 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266940006511 active site 266940006512 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266940006513 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 266940006514 putative ADP-binding pocket [chemical binding]; other site 266940006515 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266940006516 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 266940006517 thymidylate synthase; Reviewed; Region: thyA; PRK01827 266940006518 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 266940006519 dimerization interface [polypeptide binding]; other site 266940006520 active site 266940006521 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 266940006522 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 266940006523 folate binding site [chemical binding]; other site 266940006524 NADP+ binding site [chemical binding]; other site 266940006525 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 266940006526 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 266940006527 catalytic residues [active] 266940006528 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 266940006529 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 266940006530 putative metal binding site [ion binding]; other site 266940006531 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266940006532 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266940006533 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 266940006534 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 266940006535 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940006536 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 266940006537 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 266940006538 active site 266940006539 Zn binding site [ion binding]; other site 266940006540 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940006541 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940006542 metal binding site [ion binding]; metal-binding site 266940006543 active site 266940006544 I-site; other site 266940006545 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 266940006546 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 266940006547 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 266940006548 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 266940006549 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 266940006550 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 266940006551 Protein of unknown function (DUF808); Region: DUF808; cl01002 266940006552 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266940006553 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266940006554 Walker A/P-loop; other site 266940006555 ATP binding site [chemical binding]; other site 266940006556 Q-loop/lid; other site 266940006557 ABC transporter signature motif; other site 266940006558 Walker B; other site 266940006559 D-loop; other site 266940006560 H-loop/switch region; other site 266940006561 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 266940006562 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266940006563 substrate binding pocket [chemical binding]; other site 266940006564 membrane-bound complex binding site; other site 266940006565 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266940006566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940006567 ABC-ATPase subunit interface; other site 266940006568 putative PBP binding loops; other site 266940006569 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 266940006570 active site 266940006571 catalytic site [active] 266940006572 substrate binding site [chemical binding]; other site 266940006573 short chain dehydrogenase; Provisional; Region: PRK07109 266940006574 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940006575 NAD(P) binding site [chemical binding]; other site 266940006576 active site 266940006577 Nuclease-related domain; Region: NERD; pfam08378 266940006578 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 266940006579 active site 266940006580 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 266940006581 putative active site [active] 266940006582 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 266940006583 Amidase; Region: Amidase; cl11426 266940006584 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 266940006585 ADP-ribose binding site [chemical binding]; other site 266940006586 Part of AAA domain; Region: AAA_19; pfam13245 266940006587 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 266940006588 Family description; Region: UvrD_C_2; pfam13538 266940006589 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 266940006590 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 266940006591 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 266940006592 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 266940006593 active site 266940006594 catalytic residues [active] 266940006595 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 266940006596 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 266940006597 Walker A/P-loop; other site 266940006598 ATP binding site [chemical binding]; other site 266940006599 Q-loop/lid; other site 266940006600 ABC transporter signature motif; other site 266940006601 Walker B; other site 266940006602 D-loop; other site 266940006603 H-loop/switch region; other site 266940006604 FtsX-like permease family; Region: FtsX; pfam02687 266940006605 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 266940006606 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 266940006607 metal binding site [ion binding]; metal-binding site 266940006608 substrate binding pocket [chemical binding]; other site 266940006609 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266940006610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940006611 dimer interface [polypeptide binding]; other site 266940006612 conserved gate region; other site 266940006613 putative PBP binding loops; other site 266940006614 ABC-ATPase subunit interface; other site 266940006615 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 266940006616 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940006617 dimer interface [polypeptide binding]; other site 266940006618 conserved gate region; other site 266940006619 putative PBP binding loops; other site 266940006620 ABC-ATPase subunit interface; other site 266940006621 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266940006622 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266940006623 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266940006624 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266940006625 DNA-binding site [nucleotide binding]; DNA binding site 266940006626 FCD domain; Region: FCD; pfam07729 266940006627 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 266940006628 ADP-ribose binding site [chemical binding]; other site 266940006629 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 266940006630 oligomeric interface; other site 266940006631 putative active site [active] 266940006632 homodimer interface [polypeptide binding]; other site 266940006633 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 266940006634 DEAD-like helicases superfamily; Region: DEXDc; smart00487 266940006635 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266940006636 ATP binding site [chemical binding]; other site 266940006637 putative Mg++ binding site [ion binding]; other site 266940006638 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266940006639 nucleotide binding region [chemical binding]; other site 266940006640 ATP-binding site [chemical binding]; other site 266940006641 CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158 266940006642 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266940006643 ATP binding site [chemical binding]; other site 266940006644 putative Mg++ binding site [ion binding]; other site 266940006645 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266940006646 nucleotide binding region [chemical binding]; other site 266940006647 ATP-binding site [chemical binding]; other site 266940006648 DEAD/DEAH box helicase; Region: DEAD; pfam00270 266940006649 ATP binding site [chemical binding]; other site 266940006650 probable galactinol--sucrose galactosyltransferase 1; Region: PLN02355 266940006651 PLD-like domain; Region: PLDc_2; pfam13091 266940006652 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 266940006653 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 266940006654 active site 266940006655 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 266940006656 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 266940006657 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 266940006658 Ligand Binding Site [chemical binding]; other site 266940006659 DGQHR domain; Region: DGQHR; TIGR03187 266940006660 DNA-sulfur modification-associated; Region: DndB; cl17621 266940006661 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 266940006662 DNA-sulfur modification-associated; Region: DndB; cl17621 266940006663 DGQHR domain; Region: DGQHR; TIGR03187 266940006664 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 266940006665 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 266940006666 catalytic residues [active] 266940006667 catalytic nucleophile [active] 266940006668 Recombinase; Region: Recombinase; pfam07508 266940006669 EcsC protein family; Region: EcsC; pfam12787 266940006670 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 266940006671 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 266940006672 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 266940006673 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 266940006674 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 266940006675 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 266940006676 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266940006677 PAS domain; Region: PAS_9; pfam13426 266940006678 putative active site [active] 266940006679 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940006680 metal binding site [ion binding]; metal-binding site 266940006681 active site 266940006682 I-site; other site 266940006683 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266940006684 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 266940006685 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266940006686 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 266940006687 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266940006688 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940006689 Walker A/P-loop; other site 266940006690 ATP binding site [chemical binding]; other site 266940006691 Q-loop/lid; other site 266940006692 ABC transporter signature motif; other site 266940006693 Walker B; other site 266940006694 D-loop; other site 266940006695 H-loop/switch region; other site 266940006696 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 266940006697 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266940006698 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940006699 Walker A/P-loop; other site 266940006700 ATP binding site [chemical binding]; other site 266940006701 Q-loop/lid; other site 266940006702 ABC transporter signature motif; other site 266940006703 Walker B; other site 266940006704 D-loop; other site 266940006705 H-loop/switch region; other site 266940006706 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 266940006707 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 266940006708 NAD binding site [chemical binding]; other site 266940006709 catalytic Zn binding site [ion binding]; other site 266940006710 structural Zn binding site [ion binding]; other site 266940006711 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266940006712 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266940006713 putative DNA binding site [nucleotide binding]; other site 266940006714 putative Zn2+ binding site [ion binding]; other site 266940006715 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266940006716 dimerization interface [polypeptide binding]; other site 266940006717 H+ Antiporter protein; Region: 2A0121; TIGR00900 266940006718 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940006719 putative substrate translocation pore; other site 266940006720 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 266940006721 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266940006722 active site 266940006723 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 266940006724 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266940006725 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266940006726 active site 266940006727 catalytic tetrad [active] 266940006728 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 266940006729 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266940006730 ATP binding site [chemical binding]; other site 266940006731 Mg2+ binding site [ion binding]; other site 266940006732 G-X-G motif; other site 266940006733 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 266940006734 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 266940006735 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 266940006736 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 266940006737 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 266940006738 cleavage site 266940006739 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940006740 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940006741 metal binding site [ion binding]; metal-binding site 266940006742 active site 266940006743 I-site; other site 266940006744 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 266940006745 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 266940006746 molybdopterin cofactor binding site; other site 266940006747 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 266940006748 molybdopterin cofactor binding site; other site 266940006749 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 266940006750 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 266940006751 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266940006752 substrate binding site [chemical binding]; other site 266940006753 activation loop (A-loop); other site 266940006754 Transglycosylase; Region: Transgly; pfam00912 266940006755 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 266940006756 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 266940006757 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 266940006758 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 266940006759 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 266940006760 dimer interface [polypeptide binding]; other site 266940006761 ssDNA binding site [nucleotide binding]; other site 266940006762 tetramer (dimer of dimers) interface [polypeptide binding]; other site 266940006763 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 266940006764 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 266940006765 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 266940006766 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 266940006767 Clp protease ATP binding subunit; Region: clpC; CHL00095 266940006768 Clp amino terminal domain; Region: Clp_N; pfam02861 266940006769 Clp amino terminal domain; Region: Clp_N; pfam02861 266940006770 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266940006771 Walker A motif; other site 266940006772 ATP binding site [chemical binding]; other site 266940006773 Walker B motif; other site 266940006774 arginine finger; other site 266940006775 UvrB/uvrC motif; Region: UVR; pfam02151 266940006776 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266940006777 Walker A motif; other site 266940006778 ATP binding site [chemical binding]; other site 266940006779 Walker B motif; other site 266940006780 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 266940006781 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 266940006782 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 266940006783 replicative DNA helicase; Validated; Region: PRK07773 266940006784 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 266940006785 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 266940006786 Walker A motif; other site 266940006787 ATP binding site [chemical binding]; other site 266940006788 Walker B motif; other site 266940006789 DNA binding loops [nucleotide binding] 266940006790 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 266940006791 protein-splicing catalytic site; other site 266940006792 thioester formation/cholesterol transfer; other site 266940006793 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 266940006794 protein-splicing catalytic site; other site 266940006795 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 266940006796 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266940006797 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 266940006798 GAF domain; Region: GAF; pfam01590 266940006799 PAS domain S-box; Region: sensory_box; TIGR00229 266940006800 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266940006801 putative active site [active] 266940006802 heme pocket [chemical binding]; other site 266940006803 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266940006804 PAS domain; Region: PAS_9; pfam13426 266940006805 putative active site [active] 266940006806 heme pocket [chemical binding]; other site 266940006807 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266940006808 PAS domain; Region: PAS_9; pfam13426 266940006809 putative active site [active] 266940006810 heme pocket [chemical binding]; other site 266940006811 PAS domain S-box; Region: sensory_box; TIGR00229 266940006812 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266940006813 putative active site [active] 266940006814 heme pocket [chemical binding]; other site 266940006815 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940006816 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940006817 metal binding site [ion binding]; metal-binding site 266940006818 active site 266940006819 I-site; other site 266940006820 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 266940006821 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 266940006822 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 266940006823 amphipathic channel; other site 266940006824 Asn-Pro-Ala signature motifs; other site 266940006825 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 266940006826 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 266940006827 DNA polymerase IV; Provisional; Region: PRK03348 266940006828 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 266940006829 active site 266940006830 DNA binding site [nucleotide binding] 266940006831 AlkA N-terminal domain; Region: AlkA_N; pfam06029 266940006832 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 266940006833 helix-hairpin-helix signature motif; other site 266940006834 active site 266940006835 short chain dehydrogenase; Provisional; Region: PRK06123 266940006836 classical (c) SDRs; Region: SDR_c; cd05233 266940006837 NAD(P) binding site [chemical binding]; other site 266940006838 active site 266940006839 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266940006840 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069 266940006841 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266940006842 PAS domain; Region: PAS_9; pfam13426 266940006843 putative active site [active] 266940006844 heme pocket [chemical binding]; other site 266940006845 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940006846 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940006847 metal binding site [ion binding]; metal-binding site 266940006848 active site 266940006849 I-site; other site 266940006850 NAD-dependent deacetylase; Provisional; Region: PRK05333 266940006851 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 266940006852 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 266940006853 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 266940006854 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266940006855 Coenzyme A binding pocket [chemical binding]; other site 266940006856 23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522 266940006857 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266940006858 S-adenosylmethionine binding site [chemical binding]; other site 266940006859 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 266940006860 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266940006861 LabA_like proteins; Region: LabA_like; cd06167 266940006862 putative metal binding site [ion binding]; other site 266940006863 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 266940006864 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 266940006865 active site 266940006866 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 266940006867 DNA binding site [nucleotide binding] 266940006868 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 266940006869 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266940006870 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 266940006871 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266940006872 dimerization interface [polypeptide binding]; other site 266940006873 putative DNA binding site [nucleotide binding]; other site 266940006874 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266940006875 putative Zn2+ binding site [ion binding]; other site 266940006876 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 266940006877 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266940006878 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 266940006879 PAS domain S-box; Region: sensory_box; TIGR00229 266940006880 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266940006881 putative active site [active] 266940006882 heme pocket [chemical binding]; other site 266940006883 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940006884 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940006885 metal binding site [ion binding]; metal-binding site 266940006886 active site 266940006887 I-site; other site 266940006888 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266940006889 Protease prsW family; Region: PrsW-protease; pfam13367 266940006890 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 266940006891 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266940006892 ATP binding site [chemical binding]; other site 266940006893 putative Mg++ binding site [ion binding]; other site 266940006894 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266940006895 nucleotide binding region [chemical binding]; other site 266940006896 ATP-binding site [chemical binding]; other site 266940006897 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266940006898 active site 266940006899 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 266940006900 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 266940006901 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 266940006902 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 266940006903 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 266940006904 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 266940006905 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 266940006906 putative active site [active] 266940006907 catalytic site [active] 266940006908 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 266940006909 putative active site [active] 266940006910 catalytic site [active] 266940006911 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940006912 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940006913 metal binding site [ion binding]; metal-binding site 266940006914 active site 266940006915 I-site; other site 266940006916 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 266940006917 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 266940006918 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 266940006919 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 266940006920 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 266940006921 NAD(P) binding site [chemical binding]; other site 266940006922 adenylosuccinate lyase; Provisional; Region: PRK09285 266940006923 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 266940006924 tetramer interface [polypeptide binding]; other site 266940006925 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 266940006926 MOSC domain; Region: MOSC; pfam03473 266940006927 Fructosamine kinase; Region: Fructosamin_kin; cl17579 266940006928 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 266940006929 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266940006930 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266940006931 homodimer interface [polypeptide binding]; other site 266940006932 catalytic residue [active] 266940006933 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266940006934 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266940006935 non-specific DNA binding site [nucleotide binding]; other site 266940006936 salt bridge; other site 266940006937 sequence-specific DNA binding site [nucleotide binding]; other site 266940006938 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 266940006939 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 266940006940 TPP-binding site [chemical binding]; other site 266940006941 heterodimer interface [polypeptide binding]; other site 266940006942 tetramer interface [polypeptide binding]; other site 266940006943 phosphorylation loop region [posttranslational modification] 266940006944 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 266940006945 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 266940006946 alpha subunit interface [polypeptide binding]; other site 266940006947 TPP binding site [chemical binding]; other site 266940006948 heterodimer interface [polypeptide binding]; other site 266940006949 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 266940006950 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266940006951 E3 interaction surface; other site 266940006952 lipoyl attachment site [posttranslational modification]; other site 266940006953 e3 binding domain; Region: E3_binding; pfam02817 266940006954 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 266940006955 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 266940006956 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 266940006957 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 266940006958 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 266940006959 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 266940006960 active site 266940006961 putative substrate binding pocket [chemical binding]; other site 266940006962 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 266940006963 Ferritin-like domain; Region: Ferritin; pfam00210 266940006964 dimerization interface [polypeptide binding]; other site 266940006965 DPS ferroxidase diiron center [ion binding]; other site 266940006966 ion pore; other site 266940006967 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 266940006968 metal binding site 2 [ion binding]; metal-binding site 266940006969 putative DNA binding helix; other site 266940006970 metal binding site 1 [ion binding]; metal-binding site 266940006971 dimer interface [polypeptide binding]; other site 266940006972 structural Zn2+ binding site [ion binding]; other site 266940006973 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266940006974 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940006975 putative substrate translocation pore; other site 266940006976 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940006977 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266940006978 MarR family; Region: MarR_2; cl17246 266940006979 hypothetical protein; Provisional; Region: PRK00969 266940006980 Copper resistance protein D; Region: CopD; pfam05425 266940006981 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 266940006982 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK06830 266940006983 active site 266940006984 ADP/pyrophosphate binding site [chemical binding]; other site 266940006985 dimerization interface [polypeptide binding]; other site 266940006986 allosteric effector site; other site 266940006987 fructose-1,6-bisphosphate binding site; other site 266940006988 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 266940006989 active site 266940006990 metal binding site [ion binding]; metal-binding site 266940006991 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 266940006992 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 266940006993 active site 266940006994 DNA binding site [nucleotide binding] 266940006995 catalytic site [active] 266940006996 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 266940006997 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266940006998 dimer interface [polypeptide binding]; other site 266940006999 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 266940007000 putative CheW interface [polypeptide binding]; other site 266940007001 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 266940007002 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266940007003 active site 266940007004 metal binding site [ion binding]; metal-binding site 266940007005 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266940007006 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266940007007 active site 266940007008 catalytic tetrad [active] 266940007009 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 266940007010 F420-dependent oxidoreductase, CPS_4043 family; Region: F420_CPS_4043; TIGR03842 266940007011 phenylhydantoinase; Validated; Region: PRK08323 266940007012 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 266940007013 tetramer interface [polypeptide binding]; other site 266940007014 active site 266940007015 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 266940007016 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 266940007017 active site 266940007018 catalytic triad [active] 266940007019 dimer interface [polypeptide binding]; other site 266940007020 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 266940007021 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 266940007022 Na binding site [ion binding]; other site 266940007023 putative substrate binding site [chemical binding]; other site 266940007024 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266940007025 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266940007026 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266940007027 dimerization interface [polypeptide binding]; other site 266940007028 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266940007029 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266940007030 active site 266940007031 phosphorylation site [posttranslational modification] 266940007032 intermolecular recognition site; other site 266940007033 dimerization interface [polypeptide binding]; other site 266940007034 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266940007035 dimerization interface [polypeptide binding]; other site 266940007036 DNA binding residues [nucleotide binding] 266940007037 Histidine kinase; Region: HisKA_3; pfam07730 266940007038 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 266940007039 GAF domain; Region: GAF; cl17456 266940007040 GAF domain; Region: GAF_2; pfam13185 266940007041 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 266940007042 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266940007043 dimer interface [polypeptide binding]; other site 266940007044 putative CheW interface [polypeptide binding]; other site 266940007045 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266940007046 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266940007047 non-specific DNA binding site [nucleotide binding]; other site 266940007048 salt bridge; other site 266940007049 sequence-specific DNA binding site [nucleotide binding]; other site 266940007050 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 266940007051 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 266940007052 oligomer interface [polypeptide binding]; other site 266940007053 active site residues [active] 266940007054 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 266940007055 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 266940007056 oligomer interface [polypeptide binding]; other site 266940007057 active site residues [active] 266940007058 Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar3; cd08577 266940007059 putative active site [active] 266940007060 catalytic site [active] 266940007061 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266940007062 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266940007063 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266940007064 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940007065 active site 266940007066 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 266940007067 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 266940007068 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 266940007069 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266940007070 MarR family; Region: MarR; pfam01047 266940007071 thymidine kinase; Provisional; Region: PRK04296 266940007072 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940007073 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266940007074 putative substrate translocation pore; other site 266940007075 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266940007076 MarR family; Region: MarR; pfam01047 266940007077 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 266940007078 TrkA-N domain; Region: TrkA_N; pfam02254 266940007079 TrkA-C domain; Region: TrkA_C; pfam02080 266940007080 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 266940007081 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 266940007082 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 266940007083 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 266940007084 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 266940007085 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266940007086 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 266940007087 trimer interface [polypeptide binding]; other site 266940007088 active site 266940007089 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 266940007090 2',3'-cyclic-nucleotide 2'-phosphodiesterase; Region: CycNucDiestase; TIGR01390 266940007091 active site 266940007092 metal binding site [ion binding]; metal-binding site 266940007093 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 266940007094 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266940007095 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 266940007096 putative NAD(P) binding site [chemical binding]; other site 266940007097 active site 266940007098 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 266940007099 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 266940007100 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 266940007101 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 266940007102 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 266940007103 Walker A/P-loop; other site 266940007104 ATP binding site [chemical binding]; other site 266940007105 Q-loop/lid; other site 266940007106 ABC transporter signature motif; other site 266940007107 Walker B; other site 266940007108 D-loop; other site 266940007109 H-loop/switch region; other site 266940007110 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 266940007111 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940007112 Walker A/P-loop; other site 266940007113 ATP binding site [chemical binding]; other site 266940007114 Q-loop/lid; other site 266940007115 ABC transporter signature motif; other site 266940007116 Walker B; other site 266940007117 D-loop; other site 266940007118 H-loop/switch region; other site 266940007119 Cobalt transport protein; Region: CbiQ; cl00463 266940007120 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 266940007121 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 266940007122 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 266940007123 nucleotide binding site [chemical binding]; other site 266940007124 NEF interaction site [polypeptide binding]; other site 266940007125 SBD interface [polypeptide binding]; other site 266940007126 GrpE; Region: GrpE; pfam01025 266940007127 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 266940007128 dimer interface [polypeptide binding]; other site 266940007129 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 266940007130 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 266940007131 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 266940007132 HSP70 interaction site [polypeptide binding]; other site 266940007133 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 266940007134 substrate binding site [polypeptide binding]; other site 266940007135 dimer interface [polypeptide binding]; other site 266940007136 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 266940007137 DNA binding residues [nucleotide binding] 266940007138 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 266940007139 putative dimer interface [polypeptide binding]; other site 266940007140 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 266940007141 Hemerythrin-like domain; Region: Hr-like; cd12108 266940007142 Phosphotransferase enzyme family; Region: APH; pfam01636 266940007143 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 266940007144 substrate binding site [chemical binding]; other site 266940007145 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 266940007146 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266940007147 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266940007148 DNA-binding site [nucleotide binding]; DNA binding site 266940007149 FCD domain; Region: FCD; pfam07729 266940007150 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 266940007151 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940007152 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940007153 metal binding site [ion binding]; metal-binding site 266940007154 active site 266940007155 I-site; other site 266940007156 ribonuclease Z; Reviewed; Region: PRK00055 266940007157 CAAX protease self-immunity; Region: Abi; pfam02517 266940007158 Histidine kinase; Region: HisKA_3; pfam07730 266940007159 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 266940007160 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266940007161 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266940007162 active site 266940007163 phosphorylation site [posttranslational modification] 266940007164 intermolecular recognition site; other site 266940007165 dimerization interface [polypeptide binding]; other site 266940007166 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266940007167 DNA binding residues [nucleotide binding] 266940007168 dimerization interface [polypeptide binding]; other site 266940007169 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 266940007170 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266940007171 Walker A motif; other site 266940007172 ATP binding site [chemical binding]; other site 266940007173 Walker B motif; other site 266940007174 arginine finger; other site 266940007175 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266940007176 Walker A motif; other site 266940007177 ATP binding site [chemical binding]; other site 266940007178 Walker B motif; other site 266940007179 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 266940007180 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 266940007181 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 266940007182 GAF domain; Region: GAF; cl17456 266940007183 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 266940007184 Predicted amidohydrolase [General function prediction only]; Region: COG0388 266940007185 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 266940007186 putative active site [active] 266940007187 catalytic triad [active] 266940007188 putative dimer interface [polypeptide binding]; other site 266940007189 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266940007190 FCD domain; Region: FCD; pfam07729 266940007191 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940007192 metabolite-proton symporter; Region: 2A0106; TIGR00883 266940007193 putative substrate translocation pore; other site 266940007194 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 266940007195 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 266940007196 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 266940007197 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 266940007198 G1 box; other site 266940007199 putative GEF interaction site [polypeptide binding]; other site 266940007200 GTP/Mg2+ binding site [chemical binding]; other site 266940007201 Switch I region; other site 266940007202 G2 box; other site 266940007203 G3 box; other site 266940007204 Switch II region; other site 266940007205 G4 box; other site 266940007206 G5 box; other site 266940007207 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 266940007208 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 266940007209 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 266940007210 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266940007211 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 266940007212 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 266940007213 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 266940007214 short chain dehydrogenase; Provisional; Region: PRK07109 266940007215 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 266940007216 putative NAD(P) binding site [chemical binding]; other site 266940007217 active site 266940007218 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 266940007219 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 266940007220 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 266940007221 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266940007222 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266940007223 Protein of unknown function (DUF2000); Region: DUF2000; pfam09391 266940007224 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 266940007225 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 266940007226 putative catalytic site [active] 266940007227 putative phosphate binding site [ion binding]; other site 266940007228 active site 266940007229 metal binding site A [ion binding]; metal-binding site 266940007230 DNA binding site [nucleotide binding] 266940007231 putative AP binding site [nucleotide binding]; other site 266940007232 putative metal binding site B [ion binding]; other site 266940007233 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266940007234 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266940007235 DNA-binding site [nucleotide binding]; DNA binding site 266940007236 FCD domain; Region: FCD; pfam07729 266940007237 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940007238 NAD(P) binding site [chemical binding]; other site 266940007239 active site 266940007240 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266940007241 catalytic tetrad [active] 266940007242 short chain dehydrogenase; Provisional; Region: PRK06138 266940007243 classical (c) SDRs; Region: SDR_c; cd05233 266940007244 NAD(P) binding site [chemical binding]; other site 266940007245 active site 266940007246 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 266940007247 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 266940007248 metal binding site [ion binding]; metal-binding site 266940007249 substrate binding pocket [chemical binding]; other site 266940007250 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 266940007251 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266940007252 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266940007253 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940007254 dimer interface [polypeptide binding]; other site 266940007255 conserved gate region; other site 266940007256 putative PBP binding loops; other site 266940007257 ABC-ATPase subunit interface; other site 266940007258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940007259 dimer interface [polypeptide binding]; other site 266940007260 conserved gate region; other site 266940007261 ABC-ATPase subunit interface; other site 266940007262 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 266940007263 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 266940007264 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266940007265 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 266940007266 Methyltransferase domain; Region: Methyltransf_11; pfam08241 266940007267 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266940007268 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 266940007269 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 266940007270 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 266940007271 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 266940007272 active site 266940007273 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 266940007274 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 266940007275 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 266940007276 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 266940007277 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 266940007278 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 266940007279 DNA binding residues [nucleotide binding] 266940007280 TOBE domain; Region: TOBE; cl01440 266940007281 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 266940007282 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 266940007283 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 266940007284 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940007285 dimer interface [polypeptide binding]; other site 266940007286 conserved gate region; other site 266940007287 putative PBP binding loops; other site 266940007288 ABC-ATPase subunit interface; other site 266940007289 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 266940007290 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940007291 Walker A/P-loop; other site 266940007292 ATP binding site [chemical binding]; other site 266940007293 Q-loop/lid; other site 266940007294 ABC transporter signature motif; other site 266940007295 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 266940007296 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940007297 Walker A/P-loop; other site 266940007298 ATP binding site [chemical binding]; other site 266940007299 Q-loop/lid; other site 266940007300 ABC transporter signature motif; other site 266940007301 Walker B; other site 266940007302 D-loop; other site 266940007303 H-loop/switch region; other site 266940007304 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 266940007305 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 266940007306 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 266940007307 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266940007308 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266940007309 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 266940007310 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 266940007311 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 266940007312 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 266940007313 putative acyl-acceptor binding pocket; other site 266940007314 fatty acyl-CoA reductase; Region: PLN02996 266940007315 fatty acyl CoA reductases (FARs), extended (e) SDRs; Region: FAR-N_SDR_e; cd05236 266940007316 putative NAD(P) binding site [chemical binding]; other site 266940007317 active site 266940007318 putative substrate binding site [chemical binding]; other site 266940007319 C-terminal domain of fatty acyl CoA reductases; Region: FAR_C; cd09071 266940007320 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 266940007321 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 266940007322 carbon starvation protein A; Provisional; Region: PRK15015 266940007323 Carbon starvation protein CstA; Region: CstA; pfam02554 266940007324 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 266940007325 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 266940007326 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 266940007327 binding surface 266940007328 TPR motif; other site 266940007329 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266940007330 UMP phosphatase; Provisional; Region: PRK10444 266940007331 active site 266940007332 motif I; other site 266940007333 motif II; other site 266940007334 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266940007335 motif II; other site 266940007336 deoxyribose-phosphate aldolase; Provisional; Region: PRK00507 266940007337 catalytic residue [active] 266940007338 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940007339 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940007340 metal binding site [ion binding]; metal-binding site 266940007341 active site 266940007342 I-site; other site 266940007343 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266940007344 FAD binding domain; Region: FAD_binding_4; pfam01565 266940007345 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 266940007346 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940007347 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940007348 metal binding site [ion binding]; metal-binding site 266940007349 active site 266940007350 I-site; other site 266940007351 GAF domain; Region: GAF; pfam01590 266940007352 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 266940007353 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266940007354 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 266940007355 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266940007356 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266940007357 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 266940007358 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266940007359 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266940007360 DNA binding site [nucleotide binding] 266940007361 domain linker motif; other site 266940007362 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 266940007363 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 266940007364 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266940007365 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 266940007366 nucleotide binding site [chemical binding]; other site 266940007367 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 266940007368 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 266940007369 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 266940007370 Walker A/P-loop; other site 266940007371 ATP binding site [chemical binding]; other site 266940007372 Q-loop/lid; other site 266940007373 ABC transporter signature motif; other site 266940007374 Walker B; other site 266940007375 D-loop; other site 266940007376 H-loop/switch region; other site 266940007377 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940007378 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266940007379 dimer interface [polypeptide binding]; other site 266940007380 conserved gate region; other site 266940007381 putative PBP binding loops; other site 266940007382 ABC-ATPase subunit interface; other site 266940007383 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266940007384 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266940007385 substrate binding pocket [chemical binding]; other site 266940007386 membrane-bound complex binding site; other site 266940007387 hinge residues; other site 266940007388 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266940007389 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266940007390 DNA binding site [nucleotide binding] 266940007391 domain linker motif; other site 266940007392 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 266940007393 dimerization interface [polypeptide binding]; other site 266940007394 ligand binding site [chemical binding]; other site 266940007395 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 266940007396 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 266940007397 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266940007398 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 266940007399 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940007400 dimer interface [polypeptide binding]; other site 266940007401 conserved gate region; other site 266940007402 putative PBP binding loops; other site 266940007403 ABC-ATPase subunit interface; other site 266940007404 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266940007405 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940007406 dimer interface [polypeptide binding]; other site 266940007407 conserved gate region; other site 266940007408 putative PBP binding loops; other site 266940007409 ABC-ATPase subunit interface; other site 266940007410 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266940007411 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 266940007412 DNA-binding site [nucleotide binding]; DNA binding site 266940007413 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266940007414 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266940007415 homodimer interface [polypeptide binding]; other site 266940007416 catalytic residue [active] 266940007417 Predicted membrane protein [Function unknown]; Region: COG2364 266940007418 YCII-related domain; Region: YCII; cl00999 266940007419 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266940007420 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 266940007421 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 266940007422 short chain dehydrogenase; Validated; Region: PRK05855 266940007423 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 266940007424 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940007425 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 266940007426 Walker A/P-loop; other site 266940007427 ATP binding site [chemical binding]; other site 266940007428 Q-loop/lid; other site 266940007429 ABC transporter signature motif; other site 266940007430 Walker B; other site 266940007431 D-loop; other site 266940007432 H-loop/switch region; other site 266940007433 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 266940007434 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 266940007435 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 266940007436 nudix motif; other site 266940007437 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 266940007438 SPFH domain / Band 7 family; Region: Band_7; pfam01145 266940007439 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266940007440 FAD binding domain; Region: FAD_binding_4; pfam01565 266940007441 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 266940007442 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 266940007443 allantoate amidohydrolase; Reviewed; Region: PRK09290 266940007444 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 266940007445 active site 266940007446 metal binding site [ion binding]; metal-binding site 266940007447 dimer interface [polypeptide binding]; other site 266940007448 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 266940007449 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 266940007450 intracellular protease, PfpI family; Region: PfpI; TIGR01382 266940007451 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 266940007452 proposed catalytic triad [active] 266940007453 conserved cys residue [active] 266940007454 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 266940007455 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 266940007456 active site 266940007457 intersubunit interface [polypeptide binding]; other site 266940007458 zinc binding site [ion binding]; other site 266940007459 Na+ binding site [ion binding]; other site 266940007460 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 266940007461 anti sigma factor interaction site; other site 266940007462 regulatory phosphorylation site [posttranslational modification]; other site 266940007463 PAS domain; Region: PAS_9; pfam13426 266940007464 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 266940007465 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 266940007466 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 266940007467 Mg2+ binding site [ion binding]; other site 266940007468 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 266940007469 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 266940007470 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 266940007471 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 266940007472 GDP-binding site [chemical binding]; other site 266940007473 ACT binding site; other site 266940007474 IMP binding site; other site 266940007475 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 266940007476 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 266940007477 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 266940007478 active site 266940007479 catalytic site [active] 266940007480 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 266940007481 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 266940007482 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 266940007483 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 266940007484 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 266940007485 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266940007486 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266940007487 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 266940007488 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 266940007489 putative active site [active] 266940007490 catalytic site [active] 266940007491 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 266940007492 putative active site [active] 266940007493 catalytic site [active] 266940007494 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 266940007495 GAF domain; Region: GAF; pfam01590 266940007496 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940007497 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940007498 metal binding site [ion binding]; metal-binding site 266940007499 active site 266940007500 I-site; other site 266940007501 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 266940007502 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 266940007503 Tetramer interface [polypeptide binding]; other site 266940007504 active site 266940007505 FMN-binding site [chemical binding]; other site 266940007506 Cutinase; Region: Cutinase; pfam01083 266940007507 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266940007508 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 266940007509 putative DNA binding site [nucleotide binding]; other site 266940007510 putative Zn2+ binding site [ion binding]; other site 266940007511 AsnC family; Region: AsnC_trans_reg; pfam01037 266940007512 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 266940007513 [2Fe-2S] cluster binding site [ion binding]; other site 266940007514 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 266940007515 putative DNA binding site [nucleotide binding]; other site 266940007516 putative homodimer interface [polypeptide binding]; other site 266940007517 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 266940007518 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 266940007519 FAD binding pocket [chemical binding]; other site 266940007520 FAD binding motif [chemical binding]; other site 266940007521 phosphate binding motif [ion binding]; other site 266940007522 NAD binding pocket [chemical binding]; other site 266940007523 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 266940007524 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 266940007525 FAD binding pocket [chemical binding]; other site 266940007526 FAD binding motif [chemical binding]; other site 266940007527 phosphate binding motif [ion binding]; other site 266940007528 NAD binding pocket [chemical binding]; other site 266940007529 Mannosyltransferase (PIG-V)); Region: Mannosyl_trans2; pfam04188 266940007530 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266940007531 Coenzyme A binding pocket [chemical binding]; other site 266940007532 putative acetyltransferase; Provisional; Region: PRK03624 266940007533 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266940007534 Coenzyme A binding pocket [chemical binding]; other site 266940007535 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 266940007536 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 266940007537 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 266940007538 ATP-grasp domain; Region: ATP-grasp_4; cl17255 266940007539 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 266940007540 active site 266940007541 ATP binding site [chemical binding]; other site 266940007542 substrate binding site [chemical binding]; other site 266940007543 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 266940007544 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266940007545 ligand binding site [chemical binding]; other site 266940007546 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 266940007547 LrgA family; Region: LrgA; pfam03788 266940007548 LrgB-like family; Region: LrgB; cl00596 266940007549 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266940007550 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940007551 putative PBP binding loops; other site 266940007552 dimer interface [polypeptide binding]; other site 266940007553 ABC-ATPase subunit interface; other site 266940007554 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940007555 dimer interface [polypeptide binding]; other site 266940007556 conserved gate region; other site 266940007557 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266940007558 putative PBP binding loops; other site 266940007559 ABC-ATPase subunit interface; other site 266940007560 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 266940007561 Amidase; Region: Amidase; cl11426 266940007562 Amidase; Region: Amidase; cl11426 266940007563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940007564 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266940007565 putative substrate translocation pore; other site 266940007566 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940007567 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266940007568 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266940007569 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 266940007570 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266940007571 putative DNA binding site [nucleotide binding]; other site 266940007572 putative Zn2+ binding site [ion binding]; other site 266940007573 AsnC family; Region: AsnC_trans_reg; pfam01037 266940007574 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 266940007575 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 266940007576 hexamer interface [polypeptide binding]; other site 266940007577 ligand binding site [chemical binding]; other site 266940007578 putative active site [active] 266940007579 NAD(P) binding site [chemical binding]; other site 266940007580 carboxylate-amine ligase; Provisional; Region: PRK13517 266940007581 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 266940007582 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 266940007583 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266940007584 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266940007585 4-amino-4-deoxychorismate lyase; Provisional; Region: PRK07849 266940007586 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 266940007587 homodimer interface [polypeptide binding]; other site 266940007588 substrate-cofactor binding pocket; other site 266940007589 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266940007590 catalytic residue [active] 266940007591 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 266940007592 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266940007593 GAF domain; Region: GAF; pfam01590 266940007594 GAF domain; Region: GAF_3; pfam13492 266940007595 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 266940007596 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 266940007597 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 266940007598 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 266940007599 hypothetical protein; Provisional; Region: PRK06541 266940007600 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266940007601 inhibitor-cofactor binding pocket; inhibition site 266940007602 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266940007603 catalytic residue [active] 266940007604 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 266940007605 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266940007606 dimerization interface [polypeptide binding]; other site 266940007607 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266940007608 dimer interface [polypeptide binding]; other site 266940007609 putative CheW interface [polypeptide binding]; other site 266940007610 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 266940007611 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266940007612 putative ligand binding site [chemical binding]; other site 266940007613 pyridoxamine kinase; Validated; Region: PRK05756 266940007614 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 266940007615 dimer interface [polypeptide binding]; other site 266940007616 pyridoxal binding site [chemical binding]; other site 266940007617 ATP binding site [chemical binding]; other site 266940007618 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 266940007619 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 266940007620 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266940007621 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266940007622 dimerization interface [polypeptide binding]; other site 266940007623 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 266940007624 aspartate racemase; Region: asp_race; TIGR00035 266940007625 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940007626 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940007627 active site 266940007628 I-site; other site 266940007629 metal binding site [ion binding]; metal-binding site 266940007630 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 266940007631 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 266940007632 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 266940007633 putative active site [active] 266940007634 catalytic triad [active] 266940007635 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 266940007636 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 266940007637 dimerization interface [polypeptide binding]; other site 266940007638 ATP binding site [chemical binding]; other site 266940007639 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 266940007640 dimerization interface [polypeptide binding]; other site 266940007641 ATP binding site [chemical binding]; other site 266940007642 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266940007643 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 266940007644 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 266940007645 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 266940007646 Phosphotransferase enzyme family; Region: APH; pfam01636 266940007647 active site 266940007648 substrate binding site [chemical binding]; other site 266940007649 ATP binding site [chemical binding]; other site 266940007650 hypothetical protein; Provisional; Region: PRK02487 266940007651 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 266940007652 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940007653 putative substrate translocation pore; other site 266940007654 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940007655 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 266940007656 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266940007657 DNA-binding site [nucleotide binding]; DNA binding site 266940007658 UTRA domain; Region: UTRA; pfam07702 266940007659 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266940007660 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 266940007661 substrate binding site [chemical binding]; other site 266940007662 ATP binding site [chemical binding]; other site 266940007663 KduI/IolB family; Region: KduI; pfam04962 266940007664 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 266940007665 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266940007666 PYR/PP interface [polypeptide binding]; other site 266940007667 dimer interface [polypeptide binding]; other site 266940007668 TPP binding site [chemical binding]; other site 266940007669 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266940007670 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 266940007671 TPP-binding site; other site 266940007672 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 266940007673 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 266940007674 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 266940007675 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266940007676 putative ligand binding site [chemical binding]; other site 266940007677 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266940007678 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266940007679 TM-ABC transporter signature motif; other site 266940007680 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266940007681 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266940007682 Walker A/P-loop; other site 266940007683 ATP binding site [chemical binding]; other site 266940007684 Q-loop/lid; other site 266940007685 ABC transporter signature motif; other site 266940007686 Walker B; other site 266940007687 D-loop; other site 266940007688 H-loop/switch region; other site 266940007689 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266940007690 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266940007691 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 266940007692 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 266940007693 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 266940007694 Metal-binding active site; metal-binding site 266940007695 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940007696 NADH(P)-binding; Region: NAD_binding_10; pfam13460 266940007697 NAD(P) binding site [chemical binding]; other site 266940007698 active site 266940007699 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 266940007700 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266940007701 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 266940007702 DNA binding residues [nucleotide binding] 266940007703 SnoaL-like domain; Region: SnoaL_2; pfam12680 266940007704 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 266940007705 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 266940007706 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266940007707 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 266940007708 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 266940007709 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 266940007710 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266940007711 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266940007712 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 266940007713 putative dimerization interface [polypeptide binding]; other site 266940007714 amidophosphoribosyltransferase; Provisional; Region: PRK07847 266940007715 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 266940007716 active site 266940007717 tetramer interface [polypeptide binding]; other site 266940007718 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266940007719 active site 266940007720 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 266940007721 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 266940007722 dimerization interface [polypeptide binding]; other site 266940007723 putative ATP binding site [chemical binding]; other site 266940007724 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 266940007725 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 266940007726 D-xylulose kinase; Region: XylB; TIGR01312 266940007727 nucleotide binding site [chemical binding]; other site 266940007728 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940007729 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940007730 active site 266940007731 I-site; other site 266940007732 metal binding site [ion binding]; metal-binding site 266940007733 hypothetical protein; Provisional; Region: PRK07945 266940007734 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 266940007735 active site 266940007736 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 266940007737 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 266940007738 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940007739 NAD(P) binding site [chemical binding]; other site 266940007740 active site 266940007741 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 266940007742 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 266940007743 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 266940007744 acyl-CoA oxidase; Region: PLN02312 266940007745 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266940007746 active site 266940007747 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266940007748 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266940007749 WHG domain; Region: WHG; pfam13305 266940007750 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 266940007751 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266940007752 dimer interface [polypeptide binding]; other site 266940007753 active site 266940007754 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 266940007755 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940007756 NAD(P) binding site [chemical binding]; other site 266940007757 active site 266940007758 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 266940007759 classical (c) SDRs; Region: SDR_c; cd05233 266940007760 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 266940007761 NAD(P) binding site [chemical binding]; other site 266940007762 active site 266940007763 short chain dehydrogenase; Provisional; Region: PRK06523 266940007764 classical (c) SDRs; Region: SDR_c; cd05233 266940007765 NAD(P) binding site [chemical binding]; other site 266940007766 active site 266940007767 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 266940007768 Histidine kinase; Region: HisKA_3; pfam07730 266940007769 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266940007770 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 266940007771 phosphorylation site [posttranslational modification] 266940007772 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266940007773 DNA binding residues [nucleotide binding] 266940007774 dimerization interface [polypeptide binding]; other site 266940007775 benzoate transport; Region: 2A0115; TIGR00895 266940007776 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940007777 putative substrate translocation pore; other site 266940007778 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266940007779 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940007780 dimer interface [polypeptide binding]; other site 266940007781 conserved gate region; other site 266940007782 putative PBP binding loops; other site 266940007783 ABC-ATPase subunit interface; other site 266940007784 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940007785 dimer interface [polypeptide binding]; other site 266940007786 conserved gate region; other site 266940007787 putative PBP binding loops; other site 266940007788 ABC-ATPase subunit interface; other site 266940007789 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266940007790 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266940007791 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266940007792 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266940007793 DNA binding site [nucleotide binding] 266940007794 domain linker motif; other site 266940007795 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 266940007796 ligand binding site [chemical binding]; other site 266940007797 dimerization interface [polypeptide binding]; other site 266940007798 LysE type translocator; Region: LysE; cl00565 266940007799 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 266940007800 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266940007801 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266940007802 dimerization interface [polypeptide binding]; other site 266940007803 Domain of unknown function (DUF427); Region: DUF427; pfam04248 266940007804 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 266940007805 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 266940007806 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266940007807 Coenzyme A binding pocket [chemical binding]; other site 266940007808 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940007809 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 266940007810 NAD(P) binding site [chemical binding]; other site 266940007811 active site 266940007812 dihydroxyacetone kinase; Provisional; Region: PRK14479 266940007813 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 266940007814 DAK2 domain; Region: Dak2; pfam02734 266940007815 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 266940007816 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 266940007817 CoA-ligase; Region: Ligase_CoA; pfam00549 266940007818 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 266940007819 CoA binding domain; Region: CoA_binding; smart00881 266940007820 CoA-ligase; Region: Ligase_CoA; pfam00549 266940007821 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 266940007822 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 266940007823 active site 266940007824 substrate binding site [chemical binding]; other site 266940007825 cosubstrate binding site; other site 266940007826 catalytic site [active] 266940007827 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 266940007828 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 266940007829 purine monophosphate binding site [chemical binding]; other site 266940007830 dimer interface [polypeptide binding]; other site 266940007831 putative catalytic residues [active] 266940007832 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 266940007833 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 266940007834 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 266940007835 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 266940007836 active site 266940007837 dimer interface [polypeptide binding]; other site 266940007838 non-prolyl cis peptide bond; other site 266940007839 insertion regions; other site 266940007840 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 266940007841 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 266940007842 active site 266940007843 metal binding site [ion binding]; metal-binding site 266940007844 nudix motif; other site 266940007845 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 266940007846 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 266940007847 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 266940007848 isocitrate dehydrogenase; Validated; Region: PRK08299 266940007849 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 266940007850 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 266940007851 oligomer interface [polypeptide binding]; other site 266940007852 metal binding site [ion binding]; metal-binding site 266940007853 metal binding site [ion binding]; metal-binding site 266940007854 putative Cl binding site [ion binding]; other site 266940007855 basic sphincter; other site 266940007856 hydrophobic gate; other site 266940007857 periplasmic entrance; other site 266940007858 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 266940007859 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 266940007860 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 266940007861 active site 266940007862 metal-binding site 266940007863 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 266940007864 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 266940007865 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 266940007866 putative active site [active] 266940007867 putative substrate binding site [chemical binding]; other site 266940007868 putative cosubstrate binding site; other site 266940007869 catalytic site [active] 266940007870 isochorismate synthase DhbC; Validated; Region: PRK06923 266940007871 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 266940007872 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 266940007873 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 266940007874 dimer interface [polypeptide binding]; other site 266940007875 active site 266940007876 glycine-pyridoxal phosphate binding site [chemical binding]; other site 266940007877 folate binding site [chemical binding]; other site 266940007878 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 266940007879 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 266940007880 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 266940007881 homodimer interface [polypeptide binding]; other site 266940007882 NADP binding site [chemical binding]; other site 266940007883 substrate binding site [chemical binding]; other site 266940007884 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 266940007885 putative catalytic site [active] 266940007886 putative metal binding site [ion binding]; other site 266940007887 putative phosphate binding site [ion binding]; other site 266940007888 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 266940007889 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266940007890 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266940007891 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 266940007892 ATP binding site [chemical binding]; other site 266940007893 ABC transporter; Region: ABC_tran; pfam00005 266940007894 Q-loop/lid; other site 266940007895 ABC transporter signature motif; other site 266940007896 Walker B; other site 266940007897 D-loop; other site 266940007898 H-loop/switch region; other site 266940007899 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 266940007900 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940007901 Walker A/P-loop; other site 266940007902 ATP binding site [chemical binding]; other site 266940007903 Q-loop/lid; other site 266940007904 ABC transporter signature motif; other site 266940007905 Walker B; other site 266940007906 D-loop; other site 266940007907 H-loop/switch region; other site 266940007908 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 266940007909 mevalonate kinase; Region: mevalon_kin; TIGR00549 266940007910 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 266940007911 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 266940007912 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 266940007913 nucleotide binding site/active site [active] 266940007914 HIT family signature motif; other site 266940007915 catalytic residue [active] 266940007916 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 266940007917 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 266940007918 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 266940007919 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 266940007920 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 266940007921 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 266940007922 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 266940007923 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 266940007924 active site 266940007925 HIGH motif; other site 266940007926 dimer interface [polypeptide binding]; other site 266940007927 KMSKS motif; other site 266940007928 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 266940007929 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 266940007930 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 266940007931 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266940007932 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266940007933 DNA binding site [nucleotide binding] 266940007934 domain linker motif; other site 266940007935 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 266940007936 putative dimerization interface [polypeptide binding]; other site 266940007937 putative ligand binding site [chemical binding]; other site 266940007938 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266940007939 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266940007940 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940007941 dimer interface [polypeptide binding]; other site 266940007942 conserved gate region; other site 266940007943 putative PBP binding loops; other site 266940007944 ABC-ATPase subunit interface; other site 266940007945 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266940007946 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940007947 dimer interface [polypeptide binding]; other site 266940007948 conserved gate region; other site 266940007949 putative PBP binding loops; other site 266940007950 ABC-ATPase subunit interface; other site 266940007951 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 266940007952 beta-galactosidase; Region: BGL; TIGR03356 266940007953 EBNA-3B; Provisional; Region: PHA03378 266940007954 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 266940007955 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 266940007956 NAD binding site [chemical binding]; other site 266940007957 catalytic Zn binding site [ion binding]; other site 266940007958 structural Zn binding site [ion binding]; other site 266940007959 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 266940007960 active site 266940007961 iron coordination sites [ion binding]; other site 266940007962 substrate binding pocket [chemical binding]; other site 266940007963 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 266940007964 ABC1 family; Region: ABC1; cl17513 266940007965 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 266940007966 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 266940007967 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 266940007968 L-aspartate oxidase; Provisional; Region: PRK06175 266940007969 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 266940007970 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 266940007971 putative Iron-sulfur protein interface [polypeptide binding]; other site 266940007972 putative proximal heme binding site [chemical binding]; other site 266940007973 putative SdhC-like subunit interface [polypeptide binding]; other site 266940007974 putative distal heme binding site [chemical binding]; other site 266940007975 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 266940007976 putative Iron-sulfur protein interface [polypeptide binding]; other site 266940007977 putative proximal heme binding site [chemical binding]; other site 266940007978 putative SdhD-like interface [polypeptide binding]; other site 266940007979 putative distal heme binding site [chemical binding]; other site 266940007980 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 266940007981 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 266940007982 Substrate binding site; other site 266940007983 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 266940007984 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 266940007985 metal binding site [ion binding]; metal-binding site 266940007986 putative dimer interface [polypeptide binding]; other site 266940007987 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 266940007988 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 266940007989 ligand binding site [chemical binding]; other site 266940007990 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 266940007991 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266940007992 Walker A/P-loop; other site 266940007993 ATP binding site [chemical binding]; other site 266940007994 Q-loop/lid; other site 266940007995 ABC transporter signature motif; other site 266940007996 Walker B; other site 266940007997 D-loop; other site 266940007998 H-loop/switch region; other site 266940007999 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266940008000 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 266940008001 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 266940008002 TM-ABC transporter signature motif; other site 266940008003 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266940008004 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 266940008005 TM-ABC transporter signature motif; other site 266940008006 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 266940008007 active site 266940008008 catalytic motif [active] 266940008009 Zn binding site [ion binding]; other site 266940008010 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 266940008011 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 266940008012 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 266940008013 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 266940008014 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940008015 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940008016 metal binding site [ion binding]; metal-binding site 266940008017 active site 266940008018 I-site; other site 266940008019 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266940008020 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 266940008021 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 266940008022 putative active site [active] 266940008023 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940008024 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266940008025 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266940008026 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266940008027 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266940008028 dimerization interface [polypeptide binding]; other site 266940008029 EamA-like transporter family; Region: EamA; pfam00892 266940008030 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 266940008031 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266940008032 Coenzyme A binding pocket [chemical binding]; other site 266940008033 adenosine deaminase; Provisional; Region: PRK09358 266940008034 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 266940008035 active site 266940008036 HTH domain; Region: HTH_11; pfam08279 266940008037 WYL domain; Region: WYL; pfam13280 266940008038 TIGR03086 family protein; Region: TIGR03086 266940008039 GTPase RsgA; Reviewed; Region: PRK01889 266940008040 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 266940008041 GTPase/Zn-binding domain interface [polypeptide binding]; other site 266940008042 GTP/Mg2+ binding site [chemical binding]; other site 266940008043 G4 box; other site 266940008044 G5 box; other site 266940008045 G1 box; other site 266940008046 Switch I region; other site 266940008047 G2 box; other site 266940008048 G3 box; other site 266940008049 Switch II region; other site 266940008050 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266940008051 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 266940008052 putative NAD(P) binding site [chemical binding]; other site 266940008053 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266940008054 MarR family; Region: MarR_2; pfam12802 266940008055 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 266940008056 NAD(P) binding site [chemical binding]; other site 266940008057 catalytic residues [active] 266940008058 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 266940008059 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 266940008060 active site 266940008061 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 266940008062 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 266940008063 active site 266940008064 substrate binding site [chemical binding]; other site 266940008065 metal binding site [ion binding]; metal-binding site 266940008066 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 266940008067 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 266940008068 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 266940008069 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940008070 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 266940008071 Walker A/P-loop; other site 266940008072 ATP binding site [chemical binding]; other site 266940008073 Q-loop/lid; other site 266940008074 ABC transporter signature motif; other site 266940008075 Walker B; other site 266940008076 D-loop; other site 266940008077 H-loop/switch region; other site 266940008078 ABC-2 type transporter; Region: ABC2_membrane; cl17235 266940008079 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 266940008080 purine nucleoside phosphorylase; Provisional; Region: PRK08202 266940008081 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 266940008082 putative active site pocket [active] 266940008083 dimerization interface [polypeptide binding]; other site 266940008084 putative catalytic residue [active] 266940008085 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 266940008086 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266940008087 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266940008088 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266940008089 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 266940008090 Histidine kinase; Region: HisKA_3; pfam07730 266940008091 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266940008092 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266940008093 active site 266940008094 phosphorylation site [posttranslational modification] 266940008095 intermolecular recognition site; other site 266940008096 dimerization interface [polypeptide binding]; other site 266940008097 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266940008098 DNA binding residues [nucleotide binding] 266940008099 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 266940008100 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266940008101 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 266940008102 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 266940008103 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 266940008104 carboxyltransferase (CT) interaction site; other site 266940008105 biotinylation site [posttranslational modification]; other site 266940008106 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 266940008107 putative active site [active] 266940008108 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 266940008109 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 266940008110 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 266940008111 intersubunit interface [polypeptide binding]; other site 266940008112 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 266940008113 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 266940008114 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 266940008115 Predicted membrane protein [Function unknown]; Region: COG2246 266940008116 GtrA-like protein; Region: GtrA; pfam04138 266940008117 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 266940008118 ATP-grasp domain; Region: ATP-grasp_4; cl17255 266940008119 AIR carboxylase; Region: AIRC; pfam00731 266940008120 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 266940008121 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 266940008122 active site 266940008123 catalytic residues [active] 266940008124 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 266940008125 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 266940008126 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 266940008127 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 266940008128 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 266940008129 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 266940008130 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 266940008131 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 266940008132 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 266940008133 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 266940008134 Ligand binding site; other site 266940008135 Putative Catalytic site; other site 266940008136 DXD motif; other site 266940008137 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 266940008138 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 266940008139 Walker A/P-loop; other site 266940008140 ATP binding site [chemical binding]; other site 266940008141 Q-loop/lid; other site 266940008142 ABC transporter signature motif; other site 266940008143 Walker B; other site 266940008144 D-loop; other site 266940008145 H-loop/switch region; other site 266940008146 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 266940008147 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 266940008148 N- and C-terminal domain interface [polypeptide binding]; other site 266940008149 active site 266940008150 catalytic site [active] 266940008151 metal binding site [ion binding]; metal-binding site 266940008152 carbohydrate binding site [chemical binding]; other site 266940008153 ATP binding site [chemical binding]; other site 266940008154 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 266940008155 fructuronate transporter; Provisional; Region: PRK10034; cl15264 266940008156 fructuronate transporter; Provisional; Region: PRK10034; cl15264 266940008157 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266940008158 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 266940008159 FCD domain; Region: FCD; pfam07729 266940008160 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266940008161 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266940008162 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 266940008163 active site 266940008164 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 266940008165 GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; Region: GT2_AmsE_like; cd04195 266940008166 Acyltransferase family; Region: Acyl_transf_3; pfam01757 266940008167 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 266940008168 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266940008169 UDP-galactopyranose mutase; Region: GLF; pfam03275 266940008170 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 266940008171 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266940008172 active site 266940008173 ABC-2 type transporter; Region: ABC2_membrane; cl17235 266940008174 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 266940008175 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 266940008176 Walker A/P-loop; other site 266940008177 ATP binding site [chemical binding]; other site 266940008178 Q-loop/lid; other site 266940008179 ABC transporter signature motif; other site 266940008180 Walker B; other site 266940008181 D-loop; other site 266940008182 H-loop/switch region; other site 266940008183 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 266940008184 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 266940008185 active site 266940008186 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 266940008187 Predicted membrane protein [Function unknown]; Region: COG2246 266940008188 GtrA-like protein; Region: GtrA; pfam04138 266940008189 Stage II sporulation protein; Region: SpoIID; pfam08486 266940008190 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 266940008191 LGFP repeat; Region: LGFP; pfam08310 266940008192 LGFP repeat; Region: LGFP; pfam08310 266940008193 LGFP repeat; Region: LGFP; pfam08310 266940008194 LGFP repeat; Region: LGFP; pfam08310 266940008195 LGFP repeat; Region: LGFP; pfam08310 266940008196 LGFP repeat; Region: LGFP; pfam08310 266940008197 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 266940008198 amidase catalytic site [active] 266940008199 Zn binding residues [ion binding]; other site 266940008200 substrate binding site [chemical binding]; other site 266940008201 LGFP repeat; Region: LGFP; pfam08310 266940008202 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 266940008203 LGFP repeat; Region: LGFP; pfam08310 266940008204 LGFP repeat; Region: LGFP; pfam08310 266940008205 LGFP repeat; Region: LGFP; pfam08310 266940008206 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 266940008207 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 266940008208 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 266940008209 short chain dehydrogenase; Provisional; Region: PRK07024 266940008210 classical (c) SDRs; Region: SDR_c; cd05233 266940008211 NAD(P) binding site [chemical binding]; other site 266940008212 active site 266940008213 Predicted permeases [General function prediction only]; Region: COG0679 266940008214 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 266940008215 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940008216 NAD(P) binding site [chemical binding]; other site 266940008217 active site 266940008218 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 266940008219 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 266940008220 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 266940008221 TIGR03089 family protein; Region: TIGR03089 266940008222 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 266940008223 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 266940008224 Ligand binding site; other site 266940008225 Putative Catalytic site; other site 266940008226 DXD motif; other site 266940008227 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 266940008228 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266940008229 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266940008230 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266940008231 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 266940008232 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266940008233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940008234 dimer interface [polypeptide binding]; other site 266940008235 conserved gate region; other site 266940008236 putative PBP binding loops; other site 266940008237 ABC-ATPase subunit interface; other site 266940008238 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 266940008239 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940008240 dimer interface [polypeptide binding]; other site 266940008241 conserved gate region; other site 266940008242 putative PBP binding loops; other site 266940008243 ABC-ATPase subunit interface; other site 266940008244 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266940008245 ABC transporter; Region: ABC_tran; pfam00005 266940008246 Q-loop/lid; other site 266940008247 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 266940008248 ABC transporter signature motif; other site 266940008249 Walker B; other site 266940008250 D-loop; other site 266940008251 H-loop/switch region; other site 266940008252 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266940008253 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 266940008254 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266940008255 Walker A/P-loop; other site 266940008256 ATP binding site [chemical binding]; other site 266940008257 Q-loop/lid; other site 266940008258 ABC transporter signature motif; other site 266940008259 Walker B; other site 266940008260 D-loop; other site 266940008261 H-loop/switch region; other site 266940008262 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266940008263 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266940008264 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266940008265 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 266940008266 putative dimerization interface [polypeptide binding]; other site 266940008267 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 266940008268 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 266940008269 Putative cyclase; Region: Cyclase; cl00814 266940008270 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 266940008271 LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606 266940008272 phosphate binding site [ion binding]; other site 266940008273 dimer interface [polypeptide binding]; other site 266940008274 Transcription factor WhiB; Region: Whib; pfam02467 266940008275 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266940008276 Mg2+ binding site [ion binding]; other site 266940008277 G-X-G motif; other site 266940008278 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 266940008279 Protein of unknown function (DUF742); Region: DUF742; pfam05331 266940008280 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 266940008281 G2 box; other site 266940008282 Switch I region; other site 266940008283 G3 box; other site 266940008284 Switch II region; other site 266940008285 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 266940008286 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 266940008287 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 266940008288 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 266940008289 active site 266940008290 substrate binding site [chemical binding]; other site 266940008291 metal binding site [ion binding]; metal-binding site 266940008292 Trm112p-like protein; Region: Trm112p; cl01066 266940008293 bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674 266940008294 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 266940008295 Bacterial phospho-glucose isomerase C-terminal region; Region: bact-PGI_C; pfam10432 266940008296 Adenosylhomocysteinase; Provisional; Region: PTZ00075 266940008297 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 266940008298 homotetramer interface [polypeptide binding]; other site 266940008299 ligand binding site [chemical binding]; other site 266940008300 catalytic site [active] 266940008301 NAD binding site [chemical binding]; other site 266940008302 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 266940008303 active site 266940008304 catalytic triad [active] 266940008305 oxyanion hole [active] 266940008306 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 266940008307 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 266940008308 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 266940008309 active site 266940008310 catalytic site [active] 266940008311 RDD family; Region: RDD; pfam06271 266940008312 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 266940008313 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 266940008314 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266940008315 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266940008316 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266940008317 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 266940008318 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266940008319 Integral membrane protein DUF95; Region: DUF95; pfam01944 266940008320 ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]; Region: RPT1; COG1222 266940008321 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266940008322 Walker A motif; other site 266940008323 ATP binding site [chemical binding]; other site 266940008324 Walker B motif; other site 266940008325 arginine finger; other site 266940008326 Beta-lactamase; Region: Beta-lactamase; pfam00144 266940008327 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 266940008328 glucan exporter ATP-binding protein; Region: chvA; TIGR01192 266940008329 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266940008330 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940008331 Walker A/P-loop; other site 266940008332 ATP binding site [chemical binding]; other site 266940008333 Q-loop/lid; other site 266940008334 ABC transporter signature motif; other site 266940008335 Walker B; other site 266940008336 D-loop; other site 266940008337 H-loop/switch region; other site 266940008338 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940008339 ABC transporter signature motif; other site 266940008340 Walker B; other site 266940008341 D-loop; other site 266940008342 H-loop/switch region; other site 266940008343 Protein of unknown function DUF72; Region: DUF72; pfam01904 266940008344 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 266940008345 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 266940008346 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 266940008347 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 266940008348 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266940008349 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 266940008350 Walker A/P-loop; other site 266940008351 ATP binding site [chemical binding]; other site 266940008352 Q-loop/lid; other site 266940008353 ABC transporter signature motif; other site 266940008354 Walker B; other site 266940008355 D-loop; other site 266940008356 H-loop/switch region; other site 266940008357 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 266940008358 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266940008359 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940008360 Walker A/P-loop; other site 266940008361 ATP binding site [chemical binding]; other site 266940008362 Q-loop/lid; other site 266940008363 ABC transporter signature motif; other site 266940008364 Walker B; other site 266940008365 D-loop; other site 266940008366 H-loop/switch region; other site 266940008367 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 266940008368 Protein of unknown function DUF58; Region: DUF58; pfam01882 266940008369 MoxR-like ATPases [General function prediction only]; Region: COG0714 266940008370 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266940008371 Walker A motif; other site 266940008372 ATP binding site [chemical binding]; other site 266940008373 Walker B motif; other site 266940008374 arginine finger; other site 266940008375 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 266940008376 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266940008377 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266940008378 active site 266940008379 phosphorylation site [posttranslational modification] 266940008380 intermolecular recognition site; other site 266940008381 dimerization interface [polypeptide binding]; other site 266940008382 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266940008383 DNA binding site [nucleotide binding] 266940008384 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266940008385 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266940008386 dimerization interface [polypeptide binding]; other site 266940008387 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266940008388 dimer interface [polypeptide binding]; other site 266940008389 phosphorylation site [posttranslational modification] 266940008390 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266940008391 ATP binding site [chemical binding]; other site 266940008392 Mg2+ binding site [ion binding]; other site 266940008393 G-X-G motif; other site 266940008394 lipoprotein LpqB; Provisional; Region: PRK13614 266940008395 Sporulation and spore germination; Region: Germane; pfam10646 266940008396 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 266940008397 30S subunit binding site; other site 266940008398 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266940008399 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266940008400 active site 266940008401 phosphorylation site [posttranslational modification] 266940008402 intermolecular recognition site; other site 266940008403 dimerization interface [polypeptide binding]; other site 266940008404 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266940008405 DNA binding residues [nucleotide binding] 266940008406 dimerization interface [polypeptide binding]; other site 266940008407 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 266940008408 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 266940008409 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940008410 metal binding site [ion binding]; metal-binding site 266940008411 active site 266940008412 I-site; other site 266940008413 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266940008414 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 266940008415 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 266940008416 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 266940008417 nucleotide binding region [chemical binding]; other site 266940008418 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 266940008419 Helix-turn-helix domain; Region: HTH_17; pfam12728 266940008420 transcription termination factor Rho; Provisional; Region: PRK12678 266940008421 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 266940008422 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 266940008423 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 266940008424 PAS fold; Region: PAS_4; pfam08448 266940008425 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 266940008426 Histidine kinase; Region: HisKA_2; pfam07568 266940008427 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266940008428 ATP binding site [chemical binding]; other site 266940008429 G-X-G motif; other site 266940008430 Transcription factor WhiB; Region: Whib; pfam02467 266940008431 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 266940008432 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266940008433 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 266940008434 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266940008435 DNA binding residues [nucleotide binding] 266940008436 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 266940008437 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266940008438 Coenzyme A binding pocket [chemical binding]; other site 266940008439 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 266940008440 phosphopeptide binding site; other site 266940008441 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 266940008442 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 266940008443 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 266940008444 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 266940008445 ATP binding site [chemical binding]; other site 266940008446 Walker A motif; other site 266940008447 hexamer interface [polypeptide binding]; other site 266940008448 Walker B motif; other site 266940008449 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 266940008450 classical (c) SDRs; Region: SDR_c; cd05233 266940008451 NAD(P) binding site [chemical binding]; other site 266940008452 active site 266940008453 peptide chain release factor 2; Validated; Region: prfB; PRK00578 266940008454 This domain is found in peptide chain release factors; Region: PCRF; smart00937 266940008455 RF-1 domain; Region: RF-1; pfam00472 266940008456 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 266940008457 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940008458 Walker A/P-loop; other site 266940008459 ATP binding site [chemical binding]; other site 266940008460 Q-loop/lid; other site 266940008461 ABC transporter signature motif; other site 266940008462 Walker B; other site 266940008463 D-loop; other site 266940008464 H-loop/switch region; other site 266940008465 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 266940008466 FtsX-like permease family; Region: FtsX; pfam02687 266940008467 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 266940008468 SmpB-tmRNA interface; other site 266940008469 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 266940008470 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 266940008471 Walker A/P-loop; other site 266940008472 ATP binding site [chemical binding]; other site 266940008473 Q-loop/lid; other site 266940008474 ABC transporter signature motif; other site 266940008475 Walker B; other site 266940008476 D-loop; other site 266940008477 H-loop/switch region; other site 266940008478 PAS fold; Region: PAS; pfam00989 266940008479 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266940008480 putative active site [active] 266940008481 heme pocket [chemical binding]; other site 266940008482 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940008483 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940008484 metal binding site [ion binding]; metal-binding site 266940008485 active site 266940008486 I-site; other site 266940008487 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 266940008488 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 266940008489 active site 266940008490 FMN binding site [chemical binding]; other site 266940008491 substrate binding site [chemical binding]; other site 266940008492 homotetramer interface [polypeptide binding]; other site 266940008493 catalytic residue [active] 266940008494 hypothetical protein; Validated; Region: PRK00228 266940008495 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 266940008496 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 266940008497 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 266940008498 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 266940008499 ATP-binding site [chemical binding]; other site 266940008500 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 266940008501 putative hydrophobic ligand binding site [chemical binding]; other site 266940008502 tellurite resistance protein terB; Region: terB; cd07176 266940008503 putative metal binding site [ion binding]; other site 266940008504 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 266940008505 RDD family; Region: RDD; pfam06271 266940008506 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 266940008507 Isochorismatase family; Region: Isochorismatase; pfam00857 266940008508 catalytic triad [active] 266940008509 metal binding site [ion binding]; metal-binding site 266940008510 conserved cis-peptide bond; other site 266940008511 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 266940008512 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 266940008513 active site 266940008514 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 266940008515 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 266940008516 glutamate racemase; Provisional; Region: PRK00865 266940008517 ribonuclease PH; Reviewed; Region: rph; PRK00173 266940008518 Ribonuclease PH; Region: RNase_PH_bact; cd11362 266940008519 hexamer interface [polypeptide binding]; other site 266940008520 active site 266940008521 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 266940008522 active site 266940008523 dimerization interface [polypeptide binding]; other site 266940008524 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 266940008525 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 266940008526 Moco binding site; other site 266940008527 metal coordination site [ion binding]; other site 266940008528 dimerization interface [polypeptide binding]; other site 266940008529 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 266940008530 Fasciclin domain; Region: Fasciclin; pfam02469 266940008531 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 266940008532 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266940008533 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266940008534 DNA binding residues [nucleotide binding] 266940008535 Anti-sigma-K factor rskA; Region: RskA; pfam10099 266940008536 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 266940008537 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 266940008538 catalytic triad [active] 266940008539 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 266940008540 oligomerisation interface [polypeptide binding]; other site 266940008541 mobile loop; other site 266940008542 roof hairpin; other site 266940008543 Cytochrome P450; Region: p450; cl12078 266940008544 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 266940008545 homotrimer interaction site [polypeptide binding]; other site 266940008546 putative active site [active] 266940008547 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266940008548 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266940008549 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 266940008550 putative dimerization interface [polypeptide binding]; other site 266940008551 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 266940008552 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 266940008553 intersubunit interface [polypeptide binding]; other site 266940008554 trehalose synthase, Pseudomonas stutzeri type; Region: TreS_stutzeri; TIGR02455 266940008555 trehalose synthase; Region: treS_nterm; TIGR02456 266940008556 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266940008557 DNA binding site [nucleotide binding] 266940008558 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 266940008559 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266940008560 Uncharacterized conserved protein [Function unknown]; Region: COG1284 266940008561 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 266940008562 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 266940008563 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 266940008564 AsnC family; Region: AsnC_trans_reg; pfam01037 266940008565 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 266940008566 anti sigma factor interaction site; other site 266940008567 regulatory phosphorylation site [posttranslational modification]; other site 266940008568 GAF domain; Region: GAF_2; pfam13185 266940008569 ANTAR domain; Region: ANTAR; pfam03861 266940008570 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 266940008571 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266940008572 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266940008573 DNA binding site [nucleotide binding] 266940008574 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 266940008575 ligand binding site [chemical binding]; other site 266940008576 dimerization interface [polypeptide binding]; other site 266940008577 MarR family; Region: MarR; pfam01047 266940008578 GAF domain; Region: GAF; pfam01590 266940008579 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940008580 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940008581 metal binding site [ion binding]; metal-binding site 266940008582 active site 266940008583 I-site; other site 266940008584 Uncharacterized conserved protein [Function unknown]; Region: COG3538 266940008585 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 266940008586 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 266940008587 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 266940008588 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 266940008589 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 266940008590 putative active site [active] 266940008591 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266940008592 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940008593 dimer interface [polypeptide binding]; other site 266940008594 conserved gate region; other site 266940008595 putative PBP binding loops; other site 266940008596 ABC-ATPase subunit interface; other site 266940008597 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940008598 dimer interface [polypeptide binding]; other site 266940008599 conserved gate region; other site 266940008600 putative PBP binding loops; other site 266940008601 ABC-ATPase subunit interface; other site 266940008602 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266940008603 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266940008604 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 266940008605 non-specific DNA interactions [nucleotide binding]; other site 266940008606 DNA binding site [nucleotide binding] 266940008607 sequence specific DNA binding site [nucleotide binding]; other site 266940008608 putative cAMP binding site [chemical binding]; other site 266940008609 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 266940008610 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 266940008611 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 266940008612 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266940008613 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266940008614 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266940008615 TM-ABC transporter signature motif; other site 266940008616 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266940008617 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266940008618 Walker A/P-loop; other site 266940008619 ATP binding site [chemical binding]; other site 266940008620 Q-loop/lid; other site 266940008621 ABC transporter signature motif; other site 266940008622 Walker B; other site 266940008623 D-loop; other site 266940008624 H-loop/switch region; other site 266940008625 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266940008626 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 266940008627 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 266940008628 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266940008629 S-adenosylmethionine binding site [chemical binding]; other site 266940008630 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 266940008631 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266940008632 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266940008633 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266940008634 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266940008635 Domain of unknown function (DUF202); Region: DUF202; cl09954 266940008636 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 266940008637 catalytic site [active] 266940008638 putative active site [active] 266940008639 putative substrate binding site [chemical binding]; other site 266940008640 dimer interface [polypeptide binding]; other site 266940008641 Protease prsW family; Region: PrsW-protease; pfam13367 266940008642 malate:quinone oxidoreductase; Validated; Region: PRK05257 266940008643 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 266940008644 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 266940008645 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 266940008646 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 266940008647 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 266940008648 DNA binding site [nucleotide binding] 266940008649 active site 266940008650 Low molecular weight phosphatase family; Region: LMWPc; cd00115 266940008651 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 266940008652 active site 266940008653 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 266940008654 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 266940008655 Na binding site [ion binding]; other site 266940008656 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266940008657 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 266940008658 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 266940008659 Walker A/P-loop; other site 266940008660 ATP binding site [chemical binding]; other site 266940008661 Q-loop/lid; other site 266940008662 ABC transporter signature motif; other site 266940008663 Walker B; other site 266940008664 D-loop; other site 266940008665 H-loop/switch region; other site 266940008666 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 266940008667 dimer interface [polypeptide binding]; other site 266940008668 putative PBP binding regions; other site 266940008669 ABC-ATPase subunit interface; other site 266940008670 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 266940008671 ABC-ATPase subunit interface; other site 266940008672 dimer interface [polypeptide binding]; other site 266940008673 putative PBP binding regions; other site 266940008674 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 266940008675 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 266940008676 intersubunit interface [polypeptide binding]; other site 266940008677 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 266940008678 putative substrate binding site [chemical binding]; other site 266940008679 putative ATP binding site [chemical binding]; other site 266940008680 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266940008681 catalytic core [active] 266940008682 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266940008683 dimerization interface [polypeptide binding]; other site 266940008684 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 266940008685 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940008686 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940008687 metal binding site [ion binding]; metal-binding site 266940008688 active site 266940008689 I-site; other site 266940008690 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266940008691 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 266940008692 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 266940008693 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 266940008694 potassium/proton antiporter; Reviewed; Region: PRK05326 266940008695 TrkA-C domain; Region: TrkA_C; pfam02080 266940008696 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 266940008697 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266940008698 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 266940008699 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 266940008700 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 266940008701 active site 266940008702 tetramer interface; other site 266940008703 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 266940008704 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 266940008705 dimer interface [polypeptide binding]; other site 266940008706 putative functional site; other site 266940008707 putative MPT binding site; other site 266940008708 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 266940008709 trimer interface [polypeptide binding]; other site 266940008710 dimer interface [polypeptide binding]; other site 266940008711 putative active site [active] 266940008712 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 266940008713 MPT binding site; other site 266940008714 trimer interface [polypeptide binding]; other site 266940008715 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 266940008716 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 266940008717 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 266940008718 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 266940008719 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 266940008720 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266940008721 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 266940008722 Bacterial sugar transferase; Region: Bac_transf; pfam02397 266940008723 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 266940008724 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266940008725 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266940008726 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 266940008727 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266940008728 active site 266940008729 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266940008730 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 266940008731 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 266940008732 active site 266940008733 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266940008734 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 266940008735 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 266940008736 active site 266940008737 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 266940008738 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 266940008739 active site 266940008740 CoA binding site [chemical binding]; other site 266940008741 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 266940008742 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 266940008743 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 266940008744 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 266940008745 Predicted methyltransferases [General function prediction only]; Region: COG0313 266940008746 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 266940008747 putative SAM binding site [chemical binding]; other site 266940008748 putative homodimer interface [polypeptide binding]; other site 266940008749 Protein of unknown function (DUF563); Region: DUF563; pfam04577 266940008750 Protein of unknown function (DUF563); Region: DUF563; pfam04577 266940008751 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 266940008752 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 266940008753 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 266940008754 Na binding site [ion binding]; other site 266940008755 Protein of unknown function, DUF485; Region: DUF485; pfam04341 266940008756 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 266940008757 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 266940008758 active site 266940008759 putative lipid kinase; Reviewed; Region: PRK13057 266940008760 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 266940008761 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 266940008762 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 266940008763 siderophore binding site; other site 266940008764 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 266940008765 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 266940008766 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 266940008767 Walker A/P-loop; other site 266940008768 ATP binding site [chemical binding]; other site 266940008769 Q-loop/lid; other site 266940008770 ABC transporter signature motif; other site 266940008771 Walker B; other site 266940008772 D-loop; other site 266940008773 H-loop/switch region; other site 266940008774 NIL domain; Region: NIL; cl09633 266940008775 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 266940008776 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 266940008777 OsmC-like protein; Region: OsmC; pfam02566 266940008778 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 266940008779 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 266940008780 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 266940008781 active site 266940008782 non-prolyl cis peptide bond; other site 266940008783 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266940008784 active site 266940008785 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266940008786 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266940008787 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266940008788 dimerization interface [polypeptide binding]; other site 266940008789 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266940008790 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266940008791 DNA-binding site [nucleotide binding]; DNA binding site 266940008792 FCD domain; Region: FCD; pfam07729 266940008793 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940008794 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 266940008795 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266940008796 classical (c) SDRs; Region: SDR_c; cd05233 266940008797 NAD(P) binding site [chemical binding]; other site 266940008798 active site 266940008799 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 266940008800 active site 266940008801 catalytic residues [active] 266940008802 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 266940008803 ligand binding site [chemical binding]; other site 266940008804 active site 266940008805 UGI interface [polypeptide binding]; other site 266940008806 catalytic site [active] 266940008807 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 266940008808 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 266940008809 DNA-binding site [nucleotide binding]; DNA binding site 266940008810 RNA-binding motif; other site 266940008811 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 266940008812 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 266940008813 ring oligomerisation interface [polypeptide binding]; other site 266940008814 ATP/Mg binding site [chemical binding]; other site 266940008815 stacking interactions; other site 266940008816 hinge regions; other site 266940008817 RibD C-terminal domain; Region: RibD_C; pfam01872 266940008818 FAD binding domain; Region: FAD_binding_4; pfam01565 266940008819 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 266940008820 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 266940008821 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 266940008822 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofG subunit; Region: F420_cofG; TIGR03550 266940008823 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266940008824 FeS/SAM binding site; other site 266940008825 Guanylyl transferase CofC like; Region: CofC; cl17472 266940008826 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 266940008827 MoaE homodimer interface [polypeptide binding]; other site 266940008828 MoaD interaction [polypeptide binding]; other site 266940008829 active site residues [active] 266940008830 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofH subunit; Region: F420_cofH; TIGR03551 266940008831 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266940008832 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 266940008833 Ubiquitin-like proteins; Region: UBQ; cl00155 266940008834 charged pocket; other site 266940008835 hydrophobic patch; other site 266940008836 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 266940008837 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266940008838 FeS/SAM binding site; other site 266940008839 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 266940008840 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 266940008841 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 266940008842 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 266940008843 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266940008844 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266940008845 dimerization interface [polypeptide binding]; other site 266940008846 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266940008847 dimer interface [polypeptide binding]; other site 266940008848 phosphorylation site [posttranslational modification] 266940008849 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266940008850 Mg2+ binding site [ion binding]; other site 266940008851 G-X-G motif; other site 266940008852 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266940008853 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266940008854 active site 266940008855 phosphorylation site [posttranslational modification] 266940008856 intermolecular recognition site; other site 266940008857 dimerization interface [polypeptide binding]; other site 266940008858 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266940008859 DNA binding site [nucleotide binding] 266940008860 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 266940008861 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 266940008862 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 266940008863 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 266940008864 active site 266940008865 Zn binding site [ion binding]; other site 266940008866 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 266940008867 generic binding surface I; other site 266940008868 generic binding surface II; other site 266940008869 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 266940008870 putative active site [active] 266940008871 putative catalytic site [active] 266940008872 putative Mg binding site IVb [ion binding]; other site 266940008873 putative phosphate binding site [ion binding]; other site 266940008874 putative DNA binding site [nucleotide binding]; other site 266940008875 putative Mg binding site IVa [ion binding]; other site 266940008876 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 266940008877 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266940008878 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 266940008879 NAD(P) binding site [chemical binding]; other site 266940008880 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 266940008881 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 266940008882 active site 266940008883 catalytic site [active] 266940008884 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 266940008885 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 266940008886 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266940008887 ATP binding site [chemical binding]; other site 266940008888 putative Mg++ binding site [ion binding]; other site 266940008889 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266940008890 nucleotide binding region [chemical binding]; other site 266940008891 ATP-binding site [chemical binding]; other site 266940008892 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 266940008893 WYL domain; Region: WYL; pfam13280 266940008894 RNA polymerase factor sigma-70; Validated; Region: PRK08241 266940008895 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266940008896 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 266940008897 SnoaL-like domain; Region: SnoaL_2; pfam12680 266940008898 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 266940008899 active site 266940008900 homodimer interface [polypeptide binding]; other site 266940008901 homotetramer interface [polypeptide binding]; other site 266940008902 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 266940008903 Part of AAA domain; Region: AAA_19; pfam13245 266940008904 Family description; Region: UvrD_C_2; pfam13538 266940008905 Fatty acid desaturase; Region: FA_desaturase; pfam00487 266940008906 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 266940008907 putative di-iron ligands [ion binding]; other site 266940008908 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 266940008909 DNA-binding site [nucleotide binding]; DNA binding site 266940008910 RNA-binding motif; other site 266940008911 Protein of unknown function (DUF664); Region: DUF664; pfam04978 266940008912 DinB superfamily; Region: DinB_2; pfam12867 266940008913 Ion channel; Region: Ion_trans_2; pfam07885 266940008914 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 266940008915 TrkA-N domain; Region: TrkA_N; pfam02254 266940008916 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 266940008917 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 266940008918 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940008919 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940008920 metal binding site [ion binding]; metal-binding site 266940008921 active site 266940008922 I-site; other site 266940008923 aminotransferase AlaT; Validated; Region: PRK09265 266940008924 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266940008925 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266940008926 homodimer interface [polypeptide binding]; other site 266940008927 catalytic residue [active] 266940008928 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266940008929 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266940008930 DNA-binding site [nucleotide binding]; DNA binding site 266940008931 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266940008932 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266940008933 homodimer interface [polypeptide binding]; other site 266940008934 catalytic residue [active] 266940008935 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 266940008936 putative active site [active] 266940008937 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 266940008938 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 266940008939 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 266940008940 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 266940008941 oxyanion hole [active] 266940008942 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266940008943 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266940008944 DNA binding site [nucleotide binding] 266940008945 domain linker motif; other site 266940008946 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 266940008947 dimerization interface [polypeptide binding]; other site 266940008948 ligand binding site [chemical binding]; other site 266940008949 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 266940008950 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 266940008951 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 266940008952 phosphoserine aminotransferase; Provisional; Region: PRK03080 266940008953 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266940008954 catalytic residue [active] 266940008955 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 266940008956 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266940008957 S-adenosylmethionine binding site [chemical binding]; other site 266940008958 H+ Antiporter protein; Region: 2A0121; TIGR00900 266940008959 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940008960 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266940008961 MarR family; Region: MarR; pfam01047 266940008962 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940008963 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940008964 metal binding site [ion binding]; metal-binding site 266940008965 active site 266940008966 I-site; other site 266940008967 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266940008968 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 266940008969 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266940008970 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266940008971 homodimer interface [polypeptide binding]; other site 266940008972 catalytic residue [active] 266940008973 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940008974 malonic semialdehyde reductase; Provisional; Region: PRK10538 266940008975 NAD(P) binding site [chemical binding]; other site 266940008976 active site 266940008977 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 266940008978 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 266940008979 DNA-binding site [nucleotide binding]; DNA binding site 266940008980 RNA-binding motif; other site 266940008981 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 266940008982 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 266940008983 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 266940008984 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 266940008985 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266940008986 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266940008987 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266940008988 dimerization interface [polypeptide binding]; other site 266940008989 CopC domain; Region: CopC; pfam04234 266940008990 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 266940008991 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266940008992 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266940008993 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266940008994 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266940008995 DNA binding site [nucleotide binding] 266940008996 domain linker motif; other site 266940008997 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 266940008998 dimerization interface [polypeptide binding]; other site 266940008999 ligand binding site [chemical binding]; other site 266940009000 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266940009001 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266940009002 active site 266940009003 catalytic tetrad [active] 266940009004 RbsD / FucU transport protein family; Region: RbsD_FucU; pfam05025 266940009005 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 266940009006 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 266940009007 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266940009008 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266940009009 DNA binding site [nucleotide binding] 266940009010 domain linker motif; other site 266940009011 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 266940009012 dimerization interface [polypeptide binding]; other site 266940009013 ligand binding site [chemical binding]; other site 266940009014 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 266940009015 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 266940009016 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266940009017 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940009018 dimer interface [polypeptide binding]; other site 266940009019 conserved gate region; other site 266940009020 putative PBP binding loops; other site 266940009021 ABC-ATPase subunit interface; other site 266940009022 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266940009023 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940009024 dimer interface [polypeptide binding]; other site 266940009025 conserved gate region; other site 266940009026 putative PBP binding loops; other site 266940009027 ABC-ATPase subunit interface; other site 266940009028 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 266940009029 putative acetyltransferase; Provisional; Region: PRK03624 266940009030 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266940009031 Coenzyme A binding pocket [chemical binding]; other site 266940009032 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 266940009033 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 266940009034 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266940009035 catalytic residue [active] 266940009036 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 266940009037 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 266940009038 dimerization interface [polypeptide binding]; other site 266940009039 active site 266940009040 L-aspartate oxidase; Provisional; Region: PRK06175 266940009041 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 266940009042 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 266940009043 quinolinate synthetase; Provisional; Region: PRK09375 266940009044 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 266940009045 nudix motif; other site 266940009046 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 266940009047 enterobactin exporter EntS; Provisional; Region: PRK10489 266940009048 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 266940009049 DNA photolyase; Region: DNA_photolyase; pfam00875 266940009050 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 266940009051 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 266940009052 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 266940009053 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 266940009054 NlpC/P60 family; Region: NLPC_P60; pfam00877 266940009055 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 266940009056 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 266940009057 active site 266940009058 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940009059 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 266940009060 Walker A/P-loop; other site 266940009061 ATP binding site [chemical binding]; other site 266940009062 Q-loop/lid; other site 266940009063 ABC transporter signature motif; other site 266940009064 Walker B; other site 266940009065 D-loop; other site 266940009066 H-loop/switch region; other site 266940009067 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 266940009068 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940009069 Walker A/P-loop; other site 266940009070 ATP binding site [chemical binding]; other site 266940009071 Q-loop/lid; other site 266940009072 ABC transporter signature motif; other site 266940009073 Walker B; other site 266940009074 D-loop; other site 266940009075 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266940009076 RNA binding surface [nucleotide binding]; other site 266940009077 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 266940009078 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 266940009079 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 266940009080 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 266940009081 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940009082 metal binding site [ion binding]; metal-binding site 266940009083 active site 266940009084 I-site; other site 266940009085 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266940009086 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 266940009087 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 266940009088 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940009089 Walker A/P-loop; other site 266940009090 ATP binding site [chemical binding]; other site 266940009091 Q-loop/lid; other site 266940009092 ABC transporter signature motif; other site 266940009093 Walker B; other site 266940009094 D-loop; other site 266940009095 H-loop/switch region; other site 266940009096 ABC transporter; Region: ABC_tran_2; pfam12848 266940009097 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266940009098 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940009099 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940009100 metal binding site [ion binding]; metal-binding site 266940009101 active site 266940009102 I-site; other site 266940009103 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 266940009104 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 266940009105 active site 266940009106 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 266940009107 catalytic triad [active] 266940009108 dimer interface [polypeptide binding]; other site 266940009109 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266940009110 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 266940009111 NAD(P) binding site [chemical binding]; other site 266940009112 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 266940009113 active site 266940009114 catalytic site [active] 266940009115 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 266940009116 active site 266940009117 substrate-binding site [chemical binding]; other site 266940009118 metal-binding site [ion binding] 266940009119 GTP binding site [chemical binding]; other site 266940009120 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266940009121 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266940009122 non-specific DNA binding site [nucleotide binding]; other site 266940009123 salt bridge; other site 266940009124 sequence-specific DNA binding site [nucleotide binding]; other site 266940009125 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 266940009126 Domain of unknown function (DUF955); Region: DUF955; pfam06114 266940009127 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 266940009128 putative FMN binding site [chemical binding]; other site 266940009129 Predicted transcriptional regulators [Transcription]; Region: COG1733 266940009130 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 266940009131 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 266940009132 apolar tunnel; other site 266940009133 heme binding site [chemical binding]; other site 266940009134 dimerization interface [polypeptide binding]; other site 266940009135 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 266940009136 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 266940009137 putative NAD(P) binding site [chemical binding]; other site 266940009138 putative active site [active] 266940009139 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 266940009140 Mechanosensitive ion channel; Region: MS_channel; pfam00924 266940009141 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 266940009142 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266940009143 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 266940009144 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 266940009145 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 266940009146 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 266940009147 Transcription factor WhiB; Region: Whib; pfam02467 266940009148 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 266940009149 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 266940009150 Zn binding site [ion binding]; other site 266940009151 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 266940009152 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 266940009153 Protein of unknown function (DUF429); Region: DUF429; pfam04250 266940009154 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 266940009155 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 266940009156 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 266940009157 putative DNA binding site [nucleotide binding]; other site 266940009158 catalytic residue [active] 266940009159 putative H2TH interface [polypeptide binding]; other site 266940009160 putative catalytic residues [active] 266940009161 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 266940009162 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 266940009163 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 266940009164 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 266940009165 trigger factor; Provisional; Region: tig; PRK01490 266940009166 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 266940009167 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 266940009168 Clp protease; Region: CLP_protease; pfam00574 266940009169 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 266940009170 oligomer interface [polypeptide binding]; other site 266940009171 active site residues [active] 266940009172 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 266940009173 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 266940009174 oligomer interface [polypeptide binding]; other site 266940009175 active site residues [active] 266940009176 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 266940009177 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 266940009178 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 266940009179 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266940009180 Walker A motif; other site 266940009181 ATP binding site [chemical binding]; other site 266940009182 Walker B motif; other site 266940009183 arginine finger; other site 266940009184 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 266940009185 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 266940009186 YceI-like domain; Region: YceI; smart00867 266940009187 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940009188 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266940009189 putative substrate translocation pore; other site 266940009190 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940009191 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 266940009192 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 266940009193 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 266940009194 MarR family; Region: MarR; pfam01047 266940009195 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266940009196 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266940009197 MarR family; Region: MarR_2; pfam12802 266940009198 Predicted transcriptional regulators [Transcription]; Region: COG1695 266940009199 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 266940009200 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 266940009201 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 266940009202 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 266940009203 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266940009204 active site 266940009205 HIGH motif; other site 266940009206 nucleotide binding site [chemical binding]; other site 266940009207 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266940009208 active site 266940009209 KMSKS motif; other site 266940009210 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 266940009211 tRNA binding surface [nucleotide binding]; other site 266940009212 anticodon binding site; other site 266940009213 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940009214 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940009215 metal binding site [ion binding]; metal-binding site 266940009216 active site 266940009217 I-site; other site 266940009218 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 266940009219 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 266940009220 acyl-activating enzyme (AAE) consensus motif; other site 266940009221 putative AMP binding site [chemical binding]; other site 266940009222 putative active site [active] 266940009223 putative CoA binding site [chemical binding]; other site 266940009224 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266940009225 acyl-coenzyme A oxidase; Region: PLN02526 266940009226 active site 266940009227 Cache domain; Region: Cache_1; pfam02743 266940009228 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266940009229 dimerization interface [polypeptide binding]; other site 266940009230 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 266940009231 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266940009232 dimer interface [polypeptide binding]; other site 266940009233 putative CheW interface [polypeptide binding]; other site 266940009234 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266940009235 substrate binding site [chemical binding]; other site 266940009236 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 266940009237 oxyanion hole (OAH) forming residues; other site 266940009238 trimer interface [polypeptide binding]; other site 266940009239 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 266940009240 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266940009241 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266940009242 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 266940009243 dimer interface [polypeptide binding]; other site 266940009244 active site 266940009245 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 266940009246 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 266940009247 intersubunit interface [polypeptide binding]; other site 266940009248 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 266940009249 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 266940009250 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 266940009251 DXD motif; other site 266940009252 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 266940009253 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 266940009254 HIGH motif; other site 266940009255 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 266940009256 active site 266940009257 KMSKS motif; other site 266940009258 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 266940009259 tRNA binding surface [nucleotide binding]; other site 266940009260 anticodon binding site; other site 266940009261 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 266940009262 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 266940009263 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 266940009264 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 266940009265 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940009266 putative substrate translocation pore; other site 266940009267 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266940009268 Mitomycin C resistance protein (MRD); Region: MRD; cd07235 266940009269 dimer interface [polypeptide binding]; other site 266940009270 ligand binding site [chemical binding]; other site 266940009271 Helix-turn-helix domain; Region: HTH_18; pfam12833 266940009272 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 266940009273 active site 266940009274 multimer interface [polypeptide binding]; other site 266940009275 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 266940009276 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266940009277 acetyl-CoA synthetase; Provisional; Region: PRK00174 266940009278 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266940009279 acyl-activating enzyme (AAE) consensus motif; other site 266940009280 AMP binding site [chemical binding]; other site 266940009281 active site 266940009282 CoA binding site [chemical binding]; other site 266940009283 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 266940009284 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 266940009285 active site 266940009286 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 266940009287 non-prolyl cis peptide bond; other site 266940009288 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 266940009289 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 266940009290 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 266940009291 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266940009292 catalytic residue [active] 266940009293 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 266940009294 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 266940009295 trimerization site [polypeptide binding]; other site 266940009296 active site 266940009297 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266940009298 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 266940009299 putative dimerization interface [polypeptide binding]; other site 266940009300 putative ligand binding site [chemical binding]; other site 266940009301 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266940009302 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266940009303 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 266940009304 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 266940009305 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 266940009306 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 266940009307 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 266940009308 active site residue [active] 266940009309 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 266940009310 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 266940009311 homodimer interface [polypeptide binding]; other site 266940009312 substrate-cofactor binding pocket; other site 266940009313 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266940009314 catalytic residue [active] 266940009315 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 266940009316 substrate binding site [chemical binding]; other site 266940009317 THF binding site; other site 266940009318 zinc-binding site [ion binding]; other site 266940009319 Methyltransferase domain; Region: Methyltransf_23; pfam13489 266940009320 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266940009321 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 266940009322 MarR family; Region: MarR_2; pfam12802 266940009323 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 266940009324 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 266940009325 Melibiase; Region: Melibiase; pfam02065 266940009326 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 266940009327 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 266940009328 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 266940009329 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266940009330 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266940009331 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 266940009332 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940009333 dimer interface [polypeptide binding]; other site 266940009334 conserved gate region; other site 266940009335 putative PBP binding loops; other site 266940009336 ABC-ATPase subunit interface; other site 266940009337 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266940009338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940009339 dimer interface [polypeptide binding]; other site 266940009340 conserved gate region; other site 266940009341 putative PBP binding loops; other site 266940009342 ABC-ATPase subunit interface; other site 266940009343 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 266940009344 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 266940009345 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 266940009346 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 266940009347 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 266940009348 Cupin domain; Region: Cupin_2; cl17218 266940009349 Helix-turn-helix domain; Region: HTH_18; pfam12833 266940009350 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266940009351 alpha-galactosidase; Region: PLN02808; cl17638 266940009352 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 266940009353 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266940009354 active site 266940009355 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 266940009356 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 266940009357 active site 266940009358 non-prolyl cis peptide bond; other site 266940009359 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266940009360 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266940009361 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940009362 putative PBP binding loops; other site 266940009363 dimer interface [polypeptide binding]; other site 266940009364 ABC-ATPase subunit interface; other site 266940009365 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 266940009366 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 266940009367 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 266940009368 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 266940009369 homodimer interface [polypeptide binding]; other site 266940009370 oligonucleotide binding site [chemical binding]; other site 266940009371 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 266940009372 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 266940009373 GTPase CgtA; Reviewed; Region: obgE; PRK12296 266940009374 GTP1/OBG; Region: GTP1_OBG; pfam01018 266940009375 Obg GTPase; Region: Obg; cd01898 266940009376 G1 box; other site 266940009377 GTP/Mg2+ binding site [chemical binding]; other site 266940009378 Switch I region; other site 266940009379 G2 box; other site 266940009380 G3 box; other site 266940009381 Switch II region; other site 266940009382 G4 box; other site 266940009383 G5 box; other site 266940009384 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 266940009385 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 266940009386 substrate binding site [chemical binding]; other site 266940009387 nucleotide binding site [chemical binding]; other site 266940009388 PUA domain; Region: PUA; pfam01472 266940009389 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 266940009390 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 266940009391 putative catalytic cysteine [active] 266940009392 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 266940009393 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 266940009394 Ligand binding site; other site 266940009395 Putative Catalytic site; other site 266940009396 DXD motif; other site 266940009397 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 266940009398 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 266940009399 active site 266940009400 (T/H)XGH motif; other site 266940009401 Oligomerisation domain; Region: Oligomerisation; cl00519 266940009402 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266940009403 catalytic core [active] 266940009404 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 266940009405 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 266940009406 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 266940009407 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 266940009408 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 266940009409 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 266940009410 shikimate binding site; other site 266940009411 NAD(P) binding site [chemical binding]; other site 266940009412 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940009413 metal binding site [ion binding]; metal-binding site 266940009414 active site 266940009415 I-site; other site 266940009416 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 266940009417 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 266940009418 HIGH motif; other site 266940009419 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 266940009420 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266940009421 active site 266940009422 KMSKS motif; other site 266940009423 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 266940009424 tRNA binding surface [nucleotide binding]; other site 266940009425 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 266940009426 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 266940009427 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266940009428 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266940009429 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266940009430 non-specific DNA binding site [nucleotide binding]; other site 266940009431 salt bridge; other site 266940009432 sequence-specific DNA binding site [nucleotide binding]; other site 266940009433 AAA ATPase domain; Region: AAA_16; pfam13191 266940009434 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266940009435 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266940009436 dimerization interface [polypeptide binding]; other site 266940009437 DNA binding residues [nucleotide binding] 266940009438 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 266940009439 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 266940009440 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 266940009441 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 266940009442 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 266940009443 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 266940009444 Competence protein; Region: Competence; pfam03772 266940009445 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 266940009446 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 266940009447 putative active site; other site 266940009448 putative triphosphate binding site [ion binding]; other site 266940009449 putative metal binding residues [ion binding]; other site 266940009450 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 266940009451 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 266940009452 HD domain; Region: HD_3; cl17350 266940009453 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266940009454 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266940009455 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 266940009456 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 266940009457 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266940009458 YcaO-like family; Region: YcaO; pfam02624 266940009459 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266940009460 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 266940009461 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 266940009462 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266940009463 active site 266940009464 hypothetical protein; Reviewed; Region: PRK07914 266940009465 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 266940009466 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 266940009467 GTP-binding protein LepA; Provisional; Region: PRK05433 266940009468 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 266940009469 G1 box; other site 266940009470 putative GEF interaction site [polypeptide binding]; other site 266940009471 GTP/Mg2+ binding site [chemical binding]; other site 266940009472 Switch I region; other site 266940009473 G2 box; other site 266940009474 G3 box; other site 266940009475 Switch II region; other site 266940009476 G4 box; other site 266940009477 G5 box; other site 266940009478 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 266940009479 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 266940009480 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 266940009481 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 266940009482 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 266940009483 Protein of unknown function (DUF1561); Region: DUF1561; pfam07598 266940009484 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 266940009485 coproporphyrinogen III oxidase; Validated; Region: PRK05628 266940009486 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266940009487 FeS/SAM binding site; other site 266940009488 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 266940009489 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 266940009490 Tic20-like protein; Region: Tic20; pfam09685 266940009491 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 266940009492 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 266940009493 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 266940009494 chaperone protein DnaJ; Provisional; Region: PRK14278 266940009495 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 266940009496 HSP70 interaction site [polypeptide binding]; other site 266940009497 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 266940009498 Zn binding sites [ion binding]; other site 266940009499 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 266940009500 dimer interface [polypeptide binding]; other site 266940009501 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266940009502 dimer interface [polypeptide binding]; other site 266940009503 putative CheW interface [polypeptide binding]; other site 266940009504 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266940009505 PAS fold; Region: PAS_3; pfam08447 266940009506 putative active site [active] 266940009507 heme pocket [chemical binding]; other site 266940009508 Sporulation and spore germination; Region: Germane; pfam10646 266940009509 Immunoglobulin-like domain of bacterial spore germination; Region: Gmad2; pfam10648 266940009510 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 266940009511 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266940009512 DNA binding residues [nucleotide binding] 266940009513 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 266940009514 nucleotide binding site/active site [active] 266940009515 HIT family signature motif; other site 266940009516 catalytic residue [active] 266940009517 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 266940009518 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 266940009519 active site 266940009520 dimer interface [polypeptide binding]; other site 266940009521 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 266940009522 Ligand Binding Site [chemical binding]; other site 266940009523 Molecular Tunnel; other site 266940009524 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 266940009525 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 266940009526 ATP-grasp domain; Region: ATP-grasp_4; cl17255 266940009527 ATP-grasp domain; Region: ATP-grasp_4; cl17255 266940009528 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 266940009529 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 266940009530 putative DNA binding site [nucleotide binding]; other site 266940009531 catalytic residue [active] 266940009532 putative H2TH interface [polypeptide binding]; other site 266940009533 putative catalytic residues [active] 266940009534 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 266940009535 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 266940009536 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 266940009537 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 266940009538 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 266940009539 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266940009540 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 266940009541 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 266940009542 putative oligomer interface [polypeptide binding]; other site 266940009543 putative active site [active] 266940009544 metal binding site [ion binding]; metal-binding site 266940009545 Glutamine amidotransferase class-I; Region: GATase; pfam00117 266940009546 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 266940009547 glutamine binding [chemical binding]; other site 266940009548 catalytic triad [active] 266940009549 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 266940009550 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 266940009551 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 266940009552 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266940009553 PAS domain; Region: PAS_9; pfam13426 266940009554 putative active site [active] 266940009555 heme pocket [chemical binding]; other site 266940009556 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940009557 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940009558 metal binding site [ion binding]; metal-binding site 266940009559 active site 266940009560 I-site; other site 266940009561 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 266940009562 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 266940009563 homodimer interface [polypeptide binding]; other site 266940009564 substrate-cofactor binding pocket; other site 266940009565 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266940009566 catalytic residue [active] 266940009567 Protein of unknown function DUF72; Region: DUF72; pfam01904 266940009568 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 266940009569 PhoH-like protein; Region: PhoH; pfam02562 266940009570 metal-binding heat shock protein; Provisional; Region: PRK00016 266940009571 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 266940009572 Domain of unknown function DUF21; Region: DUF21; pfam01595 266940009573 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 266940009574 Transporter associated domain; Region: CorC_HlyC; smart01091 266940009575 GTPase Era; Reviewed; Region: era; PRK00089 266940009576 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 266940009577 G1 box; other site 266940009578 GTP/Mg2+ binding site [chemical binding]; other site 266940009579 Switch I region; other site 266940009580 G2 box; other site 266940009581 Switch II region; other site 266940009582 G3 box; other site 266940009583 G4 box; other site 266940009584 G5 box; other site 266940009585 KH domain; Region: KH_2; pfam07650 266940009586 Membrane protein of unknown function; Region: DUF360; pfam04020 266940009587 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 266940009588 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 266940009589 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266940009590 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266940009591 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266940009592 active site 266940009593 catalytic tetrad [active] 266940009594 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266940009595 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266940009596 active site 266940009597 catalytic tetrad [active] 266940009598 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266940009599 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266940009600 active site 266940009601 catalytic tetrad [active] 266940009602 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266940009603 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266940009604 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 266940009605 putative dimerization interface [polypeptide binding]; other site 266940009606 2-isopropylmalate synthase; Validated; Region: PRK03739 266940009607 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 266940009608 active site 266940009609 catalytic residues [active] 266940009610 metal binding site [ion binding]; metal-binding site 266940009611 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 266940009612 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940009613 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940009614 metal binding site [ion binding]; metal-binding site 266940009615 active site 266940009616 I-site; other site 266940009617 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 266940009618 Recombination protein O N terminal; Region: RecO_N; pfam11967 266940009619 Recombination protein O C terminal; Region: RecO_C; pfam02565 266940009620 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266940009621 catalytic core [active] 266940009622 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14829 266940009623 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 266940009624 catalytic residue [active] 266940009625 putative FPP diphosphate binding site; other site 266940009626 putative FPP binding hydrophobic cleft; other site 266940009627 dimer interface [polypeptide binding]; other site 266940009628 putative IPP diphosphate binding site; other site 266940009629 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 266940009630 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 266940009631 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 266940009632 IHF dimer interface [polypeptide binding]; other site 266940009633 IHF - DNA interface [nucleotide binding]; other site 266940009634 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 266940009635 metal binding site 2 [ion binding]; metal-binding site 266940009636 putative DNA binding helix; other site 266940009637 metal binding site 1 [ion binding]; metal-binding site 266940009638 dimer interface [polypeptide binding]; other site 266940009639 structural Zn2+ binding site [ion binding]; other site 266940009640 glycyl-tRNA synthetase; Provisional; Region: PRK04173 266940009641 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 266940009642 motif 1; other site 266940009643 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 266940009644 active site 266940009645 motif 2; other site 266940009646 motif 3; other site 266940009647 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 266940009648 anticodon binding site; other site 266940009649 benzoate transporter; Region: benE; TIGR00843 266940009650 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266940009651 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266940009652 DNA binding site [nucleotide binding] 266940009653 domain linker motif; other site 266940009654 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 266940009655 dimerization interface [polypeptide binding]; other site 266940009656 ligand binding site [chemical binding]; other site 266940009657 Universal stress protein UspA and related nucleotide-binding proteins [Signal transduction mechanisms]; Region: UspA; COG0589 266940009658 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 266940009659 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 266940009660 FMN binding site [chemical binding]; other site 266940009661 active site 266940009662 catalytic residues [active] 266940009663 substrate binding site [chemical binding]; other site 266940009664 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 266940009665 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 266940009666 Zn2+ binding site [ion binding]; other site 266940009667 Mg2+ binding site [ion binding]; other site 266940009668 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 266940009669 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 266940009670 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 266940009671 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 266940009672 homodimer interface [polypeptide binding]; other site 266940009673 substrate-cofactor binding pocket; other site 266940009674 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266940009675 catalytic residue [active] 266940009676 DNA primase; Validated; Region: dnaG; PRK05667 266940009677 CHC2 zinc finger; Region: zf-CHC2; pfam01807 266940009678 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 266940009679 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 266940009680 active site 266940009681 metal binding site [ion binding]; metal-binding site 266940009682 interdomain interaction site; other site 266940009683 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 266940009684 putative methyltransferase; Provisional; Region: PRK14967 266940009685 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266940009686 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 266940009687 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 266940009688 catalytic residues [active] 266940009689 threonine dehydratase; Validated; Region: PRK08639 266940009690 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 266940009691 tetramer interface [polypeptide binding]; other site 266940009692 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266940009693 catalytic residue [active] 266940009694 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 266940009695 putative Ile/Val binding site [chemical binding]; other site 266940009696 Iron permease FTR1 family; Region: FTR1; cl00475 266940009697 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 266940009698 Imelysin; Region: Peptidase_M75; pfam09375 266940009699 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 266940009700 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 266940009701 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 266940009702 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 266940009703 dimer interface [polypeptide binding]; other site 266940009704 active site 266940009705 acyl carrier protein; Provisional; Region: acpP; PRK00982 266940009706 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 266940009707 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 266940009708 dimer interface [polypeptide binding]; other site 266940009709 active site 266940009710 CoA binding pocket [chemical binding]; other site 266940009711 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 266940009712 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 266940009713 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 266940009714 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 266940009715 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 266940009716 dimer interface [polypeptide binding]; other site 266940009717 TPP-binding site [chemical binding]; other site 266940009718 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 266940009719 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 266940009720 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 266940009721 dimer interface [polypeptide binding]; other site 266940009722 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 266940009723 catalytic triad [active] 266940009724 Uncharacterized conserved protein [Function unknown]; Region: COG0327 266940009725 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 266940009726 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 266940009727 Putative zinc ribbon domain; Region: DUF164; pfam02591 266940009728 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 266940009729 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 266940009730 RNA/DNA hybrid binding site [nucleotide binding]; other site 266940009731 active site 266940009732 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266940009733 catalytic core [active] 266940009734 MMPL family; Region: MMPL; pfam03176 266940009735 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266940009736 MarR family; Region: MarR; pfam01047 266940009737 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266940009738 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266940009739 active site 266940009740 phosphorylation site [posttranslational modification] 266940009741 intermolecular recognition site; other site 266940009742 dimerization interface [polypeptide binding]; other site 266940009743 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266940009744 DNA binding residues [nucleotide binding] 266940009745 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 266940009746 Histidine kinase; Region: HisKA_3; pfam07730 266940009747 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 266940009748 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 266940009749 transmembrane helices; other site 266940009750 Protein of unknown function (DUF328); Region: DUF328; pfam03883 266940009751 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 266940009752 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 266940009753 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 266940009754 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 266940009755 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 266940009756 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 266940009757 nucleotide binding site [chemical binding]; other site 266940009758 PspC domain; Region: PspC; pfam04024 266940009759 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 266940009760 active site 266940009761 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 266940009762 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 266940009763 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 266940009764 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 266940009765 putative metal binding site [ion binding]; other site 266940009766 hypothetical protein; Provisional; Region: PRK14013 266940009767 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 266940009768 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 266940009769 putative metal binding site [ion binding]; other site 266940009770 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 266940009771 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 266940009772 putative metal binding site [ion binding]; other site 266940009773 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 266940009774 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 266940009775 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 266940009776 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266940009777 putative hydrolase; Provisional; Region: PRK11460 266940009778 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 266940009779 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 266940009780 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266940009781 catalytic residue [active] 266940009782 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 266940009783 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 266940009784 active site 266940009785 catalytic site [active] 266940009786 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 266940009787 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 266940009788 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 266940009789 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 266940009790 oligomerization interface [polypeptide binding]; other site 266940009791 active site 266940009792 metal binding site [ion binding]; metal-binding site 266940009793 NAD synthetase; Provisional; Region: PRK13981 266940009794 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 266940009795 multimer interface [polypeptide binding]; other site 266940009796 active site 266940009797 catalytic triad [active] 266940009798 protein interface 1 [polypeptide binding]; other site 266940009799 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 266940009800 homodimer interface [polypeptide binding]; other site 266940009801 NAD binding pocket [chemical binding]; other site 266940009802 ATP binding pocket [chemical binding]; other site 266940009803 Mg binding site [ion binding]; other site 266940009804 active-site loop [active] 266940009805 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 266940009806 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 266940009807 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 266940009808 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 266940009809 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 266940009810 metal binding triad; other site 266940009811 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 266940009812 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 266940009813 metal binding triad; other site 266940009814 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 266940009815 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 266940009816 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 266940009817 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 266940009818 glutamine synthetase, type I; Region: GlnA; TIGR00653 266940009819 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 266940009820 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 266940009821 RDD family; Region: RDD; pfam06271 266940009822 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 266940009823 lipoyl synthase; Provisional; Region: PRK05481 266940009824 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266940009825 FeS/SAM binding site; other site 266940009826 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 266940009827 Beta-lactamase; Region: Beta-lactamase; pfam00144 266940009828 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 266940009829 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 266940009830 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 266940009831 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 266940009832 active site 266940009833 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 266940009834 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 266940009835 active site pocket [active] 266940009836 oxyanion hole [active] 266940009837 catalytic triad [active] 266940009838 active site nucleophile [active] 266940009839 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 266940009840 Catalytic domain of Protein Kinases; Region: PKc; cd00180 266940009841 active site 266940009842 ATP binding site [chemical binding]; other site 266940009843 substrate binding site [chemical binding]; other site 266940009844 activation loop (A-loop); other site 266940009845 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940009846 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 266940009847 NAD(P) binding site [chemical binding]; other site 266940009848 active site 266940009849 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266940009850 E3 interaction surface; other site 266940009851 lipoyl attachment site [posttranslational modification]; other site 266940009852 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266940009853 E3 interaction surface; other site 266940009854 lipoyl attachment site [posttranslational modification]; other site 266940009855 e3 binding domain; Region: E3_binding; pfam02817 266940009856 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 266940009857 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 266940009858 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 266940009859 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 266940009860 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266940009861 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266940009862 multifunctional aminopeptidase A; Provisional; Region: PRK00913 266940009863 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 266940009864 interface (dimer of trimers) [polypeptide binding]; other site 266940009865 Substrate-binding/catalytic site; other site 266940009866 Zn-binding sites [ion binding]; other site 266940009867 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cl11435 266940009868 active site pocket [active] 266940009869 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 266940009870 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 266940009871 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266940009872 NAD(P) binding site [chemical binding]; other site 266940009873 catalytic residues [active] 266940009874 Protein of unknown function (DUF779); Region: DUF779; pfam05610 266940009875 putative oxidoreductase; Provisional; Region: PRK11579 266940009876 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266940009877 metabolite-proton symporter; Region: 2A0106; TIGR00883 266940009878 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940009879 putative substrate translocation pore; other site 266940009880 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 266940009881 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 266940009882 quinone interaction residues [chemical binding]; other site 266940009883 active site 266940009884 catalytic residues [active] 266940009885 FMN binding site [chemical binding]; other site 266940009886 substrate binding site [chemical binding]; other site 266940009887 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266940009888 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940009889 putative substrate translocation pore; other site 266940009890 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266940009891 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266940009892 active site 266940009893 catalytic tetrad [active] 266940009894 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 266940009895 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 266940009896 hypothetical protein; Provisional; Region: PRK07907 266940009897 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 266940009898 active site 266940009899 metal binding site [ion binding]; metal-binding site 266940009900 dimer interface [polypeptide binding]; other site 266940009901 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 266940009902 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 266940009903 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 266940009904 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 266940009905 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 266940009906 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 266940009907 D-pathway; other site 266940009908 Putative ubiquinol binding site [chemical binding]; other site 266940009909 Low-spin heme (heme b) binding site [chemical binding]; other site 266940009910 Putative water exit pathway; other site 266940009911 Binuclear center (heme o3/CuB) [ion binding]; other site 266940009912 K-pathway; other site 266940009913 Putative proton exit pathway; other site 266940009914 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 266940009915 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 266940009916 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 266940009917 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 266940009918 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 266940009919 short chain dehydrogenase; Provisional; Region: PRK07806 266940009920 NAD(P) binding site [chemical binding]; other site 266940009921 active site 266940009922 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 266940009923 interchain domain interface [polypeptide binding]; other site 266940009924 intrachain domain interface; other site 266940009925 heme bL binding site [chemical binding]; other site 266940009926 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 266940009927 heme bH binding site [chemical binding]; other site 266940009928 Qo binding site; other site 266940009929 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 266940009930 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 266940009931 iron-sulfur cluster [ion binding]; other site 266940009932 [2Fe-2S] cluster binding site [ion binding]; other site 266940009933 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266940009934 Cytochrome c; Region: Cytochrom_C; pfam00034 266940009935 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 266940009936 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 266940009937 Subunit I/III interface [polypeptide binding]; other site 266940009938 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 266940009939 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 266940009940 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 266940009941 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266940009942 AsnC family; Region: AsnC_trans_reg; pfam01037 266940009943 hypothetical protein; Validated; Region: PRK07883 266940009944 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 266940009945 active site 266940009946 catalytic site [active] 266940009947 substrate binding site [chemical binding]; other site 266940009948 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 266940009949 GIY-YIG motif/motif A; other site 266940009950 active site 266940009951 catalytic site [active] 266940009952 putative DNA binding site [nucleotide binding]; other site 266940009953 metal binding site [ion binding]; metal-binding site 266940009954 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266940009955 S-adenosylmethionine binding site [chemical binding]; other site 266940009956 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266940009957 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 266940009958 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 266940009959 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 266940009960 acyl-activating enzyme (AAE) consensus motif; other site 266940009961 putative AMP binding site [chemical binding]; other site 266940009962 putative active site [active] 266940009963 putative CoA binding site [chemical binding]; other site 266940009964 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 266940009965 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 266940009966 nucleotide binding site [chemical binding]; other site 266940009967 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 266940009968 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 266940009969 nucleotide binding site [chemical binding]; other site 266940009970 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 266940009971 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 266940009972 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 266940009973 putative acyl-acceptor binding pocket; other site 266940009974 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 266940009975 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 266940009976 active site 266940009977 ADP/pyrophosphate binding site [chemical binding]; other site 266940009978 dimerization interface [polypeptide binding]; other site 266940009979 allosteric effector site; other site 266940009980 fructose-1,6-bisphosphate binding site; other site 266940009981 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 266940009982 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 266940009983 Catalytic domain of Protein Kinases; Region: PKc; cd00180 266940009984 active site 266940009985 ATP binding site [chemical binding]; other site 266940009986 substrate binding site [chemical binding]; other site 266940009987 activation loop (A-loop); other site 266940009988 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 266940009989 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 266940009990 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 266940009991 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 266940009992 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 266940009993 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 266940009994 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 266940009995 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 266940009996 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 266940009997 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 266940009998 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266940009999 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266940010000 catalytic residue [active] 266940010001 Helix-turn-helix domain; Region: HTH_17; pfam12728 266940010002 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 266940010003 active site lid residues [active] 266940010004 substrate binding pocket [chemical binding]; other site 266940010005 catalytic residues [active] 266940010006 substrate-Mg2+ binding site; other site 266940010007 aspartate-rich region 1; other site 266940010008 aspartate-rich region 2; other site 266940010009 phytoene desaturase; Region: crtI_fam; TIGR02734 266940010010 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266940010011 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 266940010012 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 266940010013 substrate binding pocket [chemical binding]; other site 266940010014 chain length determination region; other site 266940010015 substrate-Mg2+ binding site; other site 266940010016 catalytic residues [active] 266940010017 aspartate-rich region 1; other site 266940010018 active site lid residues [active] 266940010019 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 266940010020 aspartate-rich region 2; other site 266940010021 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 266940010022 phytoene desaturase; Region: crtI_fam; TIGR02734 266940010023 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266940010024 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266940010025 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 266940010026 active site 266940010027 Protein of unknown function (DUF422); Region: DUF422; cl00991 266940010028 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266940010029 YbaK / prolyl-tRNA synthetases associated domain; Region: YbaK; pfam04073 266940010030 putative deacylase active site [active] 266940010031 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 266940010032 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 266940010033 active site 266940010034 PHP Thumb interface [polypeptide binding]; other site 266940010035 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 266940010036 generic binding surface II; other site 266940010037 generic binding surface I; other site 266940010038 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266940010039 DNA polymerase IV; Validated; Region: PRK03858 266940010040 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 266940010041 active site 266940010042 DNA binding site [nucleotide binding] 266940010043 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 266940010044 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 266940010045 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 266940010046 Protein of unknown function DUF58; Region: DUF58; pfam01882 266940010047 MoxR-like ATPases [General function prediction only]; Region: COG0714 266940010048 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266940010049 Walker A motif; other site 266940010050 ATP binding site [chemical binding]; other site 266940010051 Walker B motif; other site 266940010052 arginine finger; other site 266940010053 cell division protein MraZ; Reviewed; Region: PRK00326 266940010054 MraZ protein; Region: MraZ; pfam02381 266940010055 MraZ protein; Region: MraZ; pfam02381 266940010056 MraW methylase family; Region: Methyltransf_5; cl17771 266940010057 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 266940010058 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 266940010059 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 266940010060 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 266940010061 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 266940010062 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 266940010063 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 266940010064 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 266940010065 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 266940010066 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 266940010067 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 266940010068 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 266940010069 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 266940010070 Mg++ binding site [ion binding]; other site 266940010071 putative catalytic motif [active] 266940010072 putative substrate binding site [chemical binding]; other site 266940010073 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 266940010074 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 266940010075 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 266940010076 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 266940010077 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 266940010078 active site 266940010079 homodimer interface [polypeptide binding]; other site 266940010080 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 266940010081 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 266940010082 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 266940010083 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 266940010084 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 266940010085 Cell division protein FtsQ; Region: FtsQ; pfam03799 266940010086 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 266940010087 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 266940010088 nucleotide binding site [chemical binding]; other site 266940010089 SulA interaction site; other site 266940010090 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 266940010091 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 266940010092 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266940010093 catalytic residue [active] 266940010094 Protein of unknown function (DUF552); Region: DUF552; pfam04472 266940010095 DivIVA domain; Region: DivI1A_domain; TIGR03544 266940010096 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 266940010097 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 266940010098 lipoprotein signal peptidase; Provisional; Region: PRK14787 266940010099 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 266940010100 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266940010101 RNA binding surface [nucleotide binding]; other site 266940010102 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 266940010103 active site 266940010104 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 266940010105 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 266940010106 active site 266940010107 PHP Thumb interface [polypeptide binding]; other site 266940010108 metal binding site [ion binding]; metal-binding site 266940010109 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 266940010110 generic binding surface II; other site 266940010111 generic binding surface I; other site 266940010112 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 266940010113 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940010114 putative substrate translocation pore; other site 266940010115 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 266940010116 putative deacylase active site [active] 266940010117 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 266940010118 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 266940010119 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 266940010120 NAD binding site [chemical binding]; other site 266940010121 dimerization interface [polypeptide binding]; other site 266940010122 product binding site; other site 266940010123 substrate binding site [chemical binding]; other site 266940010124 zinc binding site [ion binding]; other site 266940010125 catalytic residues [active] 266940010126 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266940010127 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266940010128 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 266940010129 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266940010130 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266940010131 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 266940010132 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 266940010133 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266940010134 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266940010135 homodimer interface [polypeptide binding]; other site 266940010136 catalytic residue [active] 266940010137 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 266940010138 putative active site pocket [active] 266940010139 4-fold oligomerization interface [polypeptide binding]; other site 266940010140 metal binding residues [ion binding]; metal-binding site 266940010141 3-fold/trimer interface [polypeptide binding]; other site 266940010142 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 266940010143 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 266940010144 putative active site [active] 266940010145 oxyanion strand; other site 266940010146 catalytic triad [active] 266940010147 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 266940010148 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 266940010149 catalytic residues [active] 266940010150 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 266940010151 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 266940010152 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 266940010153 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 266940010154 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 266940010155 23S rRNA binding site [nucleotide binding]; other site 266940010156 L21 binding site [polypeptide binding]; other site 266940010157 L13 binding site [polypeptide binding]; other site 266940010158 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 266940010159 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 266940010160 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 266940010161 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 266940010162 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266940010163 dimer interface [polypeptide binding]; other site 266940010164 phosphorylation site [posttranslational modification] 266940010165 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266940010166 ATP binding site [chemical binding]; other site 266940010167 Mg2+ binding site [ion binding]; other site 266940010168 G-X-G motif; other site 266940010169 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 266940010170 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 266940010171 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 266940010172 dimer interface [polypeptide binding]; other site 266940010173 motif 1; other site 266940010174 active site 266940010175 motif 2; other site 266940010176 motif 3; other site 266940010177 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 266940010178 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 266940010179 putative tRNA-binding site [nucleotide binding]; other site 266940010180 B3/4 domain; Region: B3_4; pfam03483 266940010181 tRNA synthetase B5 domain; Region: B5; smart00874 266940010182 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 266940010183 motif 1; other site 266940010184 dimer interface [polypeptide binding]; other site 266940010185 active site 266940010186 motif 2; other site 266940010187 motif 3; other site 266940010188 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 266940010189 classical (c) SDRs; Region: SDR_c; cd05233 266940010190 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 266940010191 NAD(P) binding site [chemical binding]; other site 266940010192 active site 266940010193 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 266940010194 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 266940010195 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 266940010196 heterotetramer interface [polypeptide binding]; other site 266940010197 active site pocket [active] 266940010198 cleavage site 266940010199 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 266940010200 feedback inhibition sensing region; other site 266940010201 homohexameric interface [polypeptide binding]; other site 266940010202 nucleotide binding site [chemical binding]; other site 266940010203 N-acetyl-L-glutamate binding site [chemical binding]; other site 266940010204 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 266940010205 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266940010206 inhibitor-cofactor binding pocket; inhibition site 266940010207 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266940010208 catalytic residue [active] 266940010209 ornithine carbamoyltransferase; Provisional; Region: PRK00779 266940010210 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 266940010211 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 266940010212 arginine repressor; Provisional; Region: PRK03341 266940010213 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 266940010214 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 266940010215 argininosuccinate lyase; Provisional; Region: PRK00855 266940010216 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 266940010217 active sites [active] 266940010218 tetramer interface [polypeptide binding]; other site 266940010219 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 266940010220 active site 266940010221 DNA binding site [nucleotide binding] 266940010222 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 266940010223 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 266940010224 active site 266940010225 HIGH motif; other site 266940010226 dimer interface [polypeptide binding]; other site 266940010227 KMSKS motif; other site 266940010228 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266940010229 RNA binding surface [nucleotide binding]; other site 266940010230 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 266940010231 Uncharacterized conserved protein [Function unknown]; Region: COG4198 266940010232 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 266940010233 binding surface 266940010234 Tetratricopeptide repeat; Region: TPR_16; pfam13432 266940010235 TPR motif; other site 266940010236 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 266940010237 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 266940010238 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 266940010239 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 266940010240 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 266940010241 RNA binding surface [nucleotide binding]; other site 266940010242 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266940010243 S-adenosylmethionine binding site [chemical binding]; other site 266940010244 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 266940010245 ATP-NAD kinase; Region: NAD_kinase; pfam01513 266940010246 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 266940010247 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940010248 Walker A/P-loop; other site 266940010249 ATP binding site [chemical binding]; other site 266940010250 Q-loop/lid; other site 266940010251 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 266940010252 ABC transporter signature motif; other site 266940010253 Walker B; other site 266940010254 D-loop; other site 266940010255 H-loop/switch region; other site 266940010256 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 266940010257 Thiamine pyrophosphokinase; Region: TPK; cl08415 266940010258 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 266940010259 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 266940010260 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 266940010261 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 266940010262 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266940010263 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266940010264 CTP synthetase; Validated; Region: pyrG; PRK05380 266940010265 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 266940010266 Catalytic site [active] 266940010267 active site 266940010268 UTP binding site [chemical binding]; other site 266940010269 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 266940010270 active site 266940010271 putative oxyanion hole; other site 266940010272 catalytic triad [active] 266940010273 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 266940010274 dimer interface [polypeptide binding]; other site 266940010275 ADP-ribose binding site [chemical binding]; other site 266940010276 active site 266940010277 nudix motif; other site 266940010278 metal binding site [ion binding]; metal-binding site 266940010279 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 266940010280 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266940010281 active site 266940010282 DNA binding site [nucleotide binding] 266940010283 Int/Topo IB signature motif; other site 266940010284 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 266940010285 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266940010286 P-loop; other site 266940010287 Magnesium ion binding site [ion binding]; other site 266940010288 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266940010289 Magnesium ion binding site [ion binding]; other site 266940010290 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266940010291 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 266940010292 acyl-activating enzyme (AAE) consensus motif; other site 266940010293 AMP binding site [chemical binding]; other site 266940010294 active site 266940010295 CoA binding site [chemical binding]; other site 266940010296 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 266940010297 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 266940010298 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 266940010299 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 266940010300 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 266940010301 ATP binding site [chemical binding]; other site 266940010302 Walker A motif; other site 266940010303 hexamer interface [polypeptide binding]; other site 266940010304 Walker B motif; other site 266940010305 TadE-like protein; Region: TadE; pfam07811 266940010306 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 266940010307 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 266940010308 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 266940010309 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 266940010310 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 266940010311 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 266940010312 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266940010313 RNA binding surface [nucleotide binding]; other site 266940010314 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 266940010315 active site 266940010316 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 266940010317 homotrimer interaction site [polypeptide binding]; other site 266940010318 active site 266940010319 prephenate dehydrogenase; Validated; Region: PRK06545 266940010320 prephenate dehydrogenase; Validated; Region: PRK08507 266940010321 cytidylate kinase; Provisional; Region: cmk; PRK00023 266940010322 AAA domain; Region: AAA_17; pfam13207 266940010323 Cytidylate kinase; Region: Cytidylate_kin; pfam02224 266940010324 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 266940010325 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 266940010326 putative acyl-acceptor binding pocket; other site 266940010327 GTP-binding protein Der; Reviewed; Region: PRK03003 266940010328 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 266940010329 G1 box; other site 266940010330 GTP/Mg2+ binding site [chemical binding]; other site 266940010331 Switch I region; other site 266940010332 G2 box; other site 266940010333 Switch II region; other site 266940010334 G3 box; other site 266940010335 G4 box; other site 266940010336 G5 box; other site 266940010337 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 266940010338 G1 box; other site 266940010339 GTP/Mg2+ binding site [chemical binding]; other site 266940010340 Switch I region; other site 266940010341 G2 box; other site 266940010342 G3 box; other site 266940010343 Switch II region; other site 266940010344 G4 box; other site 266940010345 G5 box; other site 266940010346 hypothetical protein; Provisional; Region: PRK02237 266940010347 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266940010348 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266940010349 Walker A/P-loop; other site 266940010350 ATP binding site [chemical binding]; other site 266940010351 Q-loop/lid; other site 266940010352 ABC transporter signature motif; other site 266940010353 Walker B; other site 266940010354 D-loop; other site 266940010355 H-loop/switch region; other site 266940010356 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266940010357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940010358 ABC-ATPase subunit interface; other site 266940010359 putative PBP binding loops; other site 266940010360 NMT1/THI5 like; Region: NMT1; pfam09084 266940010361 pyrimidine utilization protein A; Region: RutA; TIGR03612 266940010362 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 266940010363 active site 266940010364 dimer interface [polypeptide binding]; other site 266940010365 non-prolyl cis peptide bond; other site 266940010366 insertion regions; other site 266940010367 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 266940010368 Isochorismatase family; Region: Isochorismatase; pfam00857 266940010369 catalytic triad [active] 266940010370 conserved cis-peptide bond; other site 266940010371 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 266940010372 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266940010373 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266940010374 DNA binding residues [nucleotide binding] 266940010375 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 266940010376 active site 266940010377 putative catalytic site [active] 266940010378 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 266940010379 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 266940010380 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 266940010381 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266940010382 ATP binding site [chemical binding]; other site 266940010383 putative Mg++ binding site [ion binding]; other site 266940010384 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266940010385 nucleotide binding region [chemical binding]; other site 266940010386 ATP-binding site [chemical binding]; other site 266940010387 Helicase associated domain (HA2); Region: HA2; pfam04408 266940010388 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 266940010389 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 266940010390 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 266940010391 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 266940010392 putative dimer interface [polypeptide binding]; other site 266940010393 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 266940010394 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 266940010395 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 266940010396 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 266940010397 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 266940010398 lipoyl attachment site [posttranslational modification]; other site 266940010399 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 266940010400 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 266940010401 phosphopeptide binding site; other site 266940010402 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 266940010403 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 266940010404 DNA binding residues [nucleotide binding] 266940010405 Bifunctional nuclease; Region: DNase-RNase; pfam02577 266940010406 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 266940010407 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 266940010408 DNA binding residues [nucleotide binding] 266940010409 putative dimer interface [polypeptide binding]; other site 266940010410 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 266940010411 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266940010412 P-loop; other site 266940010413 Magnesium ion binding site [ion binding]; other site 266940010414 glycine dehydrogenase; Provisional; Region: PRK05367 266940010415 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266940010416 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266940010417 catalytic residue [active] 266940010418 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 266940010419 tetramer interface [polypeptide binding]; other site 266940010420 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266940010421 catalytic residue [active] 266940010422 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 266940010423 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 266940010424 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 266940010425 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 266940010426 Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002 266940010427 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 266940010428 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 266940010429 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 266940010430 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 266940010431 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 266940010432 Fe-S metabolism associated domain; Region: SufE; cl00951 266940010433 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 266940010434 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 266940010435 active site residue [active] 266940010436 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 266940010437 active site residue [active] 266940010438 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 266940010439 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 266940010440 High-affinity nickel-transport protein; Region: NicO; cl00964 266940010441 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 266940010442 nudix motif; other site 266940010443 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 266940010444 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 266940010445 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 266940010446 catalytic site [active] 266940010447 active site 266940010448 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 266940010449 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 266940010450 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 266940010451 active site 266940010452 catalytic site [active] 266940010453 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 266940010454 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 266940010455 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 266940010456 active site 266940010457 catalytic site [active] 266940010458 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 266940010459 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266940010460 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 266940010461 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 266940010462 putative ADP-binding pocket [chemical binding]; other site 266940010463 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266940010464 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 266940010465 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 266940010466 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 266940010467 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 266940010468 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 266940010469 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 266940010470 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 266940010471 active site 266940010472 dimer interface [polypeptide binding]; other site 266940010473 motif 1; other site 266940010474 motif 2; other site 266940010475 motif 3; other site 266940010476 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 266940010477 anticodon binding site; other site 266940010478 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 266940010479 nucleotide binding site/active site [active] 266940010480 HIT family signature motif; other site 266940010481 catalytic residue [active] 266940010482 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 266940010483 lipid A biosynthesis lauroyl acyltransferase; Provisional; Region: PRK07920 266940010484 putative acyl-acceptor binding pocket; other site 266940010485 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266940010486 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 266940010487 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 266940010488 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 266940010489 active site 266940010490 multimer interface [polypeptide binding]; other site 266940010491 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 266940010492 nudix motif; other site 266940010493 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 266940010494 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13143 266940010495 predicted active site [active] 266940010496 catalytic triad [active] 266940010497 hypothetical protein; Validated; Region: PRK00110 266940010498 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 266940010499 active site 266940010500 putative DNA-binding cleft [nucleotide binding]; other site 266940010501 dimer interface [polypeptide binding]; other site 266940010502 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 266940010503 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266940010504 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 266940010505 RuvA N terminal domain; Region: RuvA_N; pfam01330 266940010506 Y-family of DNA polymerases; Region: PolY; cl12025 266940010507 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 266940010508 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266940010509 Walker A motif; other site 266940010510 ATP binding site [chemical binding]; other site 266940010511 Walker B motif; other site 266940010512 arginine finger; other site 266940010513 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 266940010514 Preprotein translocase subunit; Region: YajC; pfam02699 266940010515 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 266940010516 Protein export membrane protein; Region: SecD_SecF; cl14618 266940010517 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 266940010518 Protein export membrane protein; Region: SecD_SecF; pfam02355 266940010519 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266940010520 active site 266940010521 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 266940010522 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 266940010523 Zn2+ binding site [ion binding]; other site 266940010524 Mg2+ binding site [ion binding]; other site 266940010525 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 266940010526 synthetase active site [active] 266940010527 NTP binding site [chemical binding]; other site 266940010528 metal binding site [ion binding]; metal-binding site 266940010529 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 266940010530 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 266940010531 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 266940010532 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 266940010533 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 266940010534 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 266940010535 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 266940010536 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 266940010537 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 266940010538 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 266940010539 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 266940010540 dimer interface [polypeptide binding]; other site 266940010541 anticodon binding site; other site 266940010542 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 266940010543 homodimer interface [polypeptide binding]; other site 266940010544 motif 1; other site 266940010545 active site 266940010546 motif 2; other site 266940010547 GAD domain; Region: GAD; pfam02938 266940010548 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 266940010549 active site 266940010550 motif 3; other site 266940010551 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266940010552 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266940010553 dimer interface [polypeptide binding]; other site 266940010554 phosphorylation site [posttranslational modification] 266940010555 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266940010556 ATP binding site [chemical binding]; other site 266940010557 Mg2+ binding site [ion binding]; other site 266940010558 G-X-G motif; other site 266940010559 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266940010560 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266940010561 active site 266940010562 phosphorylation site [posttranslational modification] 266940010563 intermolecular recognition site; other site 266940010564 dimerization interface [polypeptide binding]; other site 266940010565 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266940010566 DNA binding site [nucleotide binding] 266940010567 recombination factor protein RarA; Reviewed; Region: PRK13342 266940010568 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266940010569 Walker A motif; other site 266940010570 ATP binding site [chemical binding]; other site 266940010571 Walker B motif; other site 266940010572 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 266940010573 PemK-like protein; Region: PemK; pfam02452 266940010574 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 266940010575 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 266940010576 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 266940010577 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 266940010578 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 266940010579 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 266940010580 motif 1; other site 266940010581 active site 266940010582 motif 2; other site 266940010583 motif 3; other site 266940010584 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 266940010585 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 266940010586 YceG-like family; Region: YceG; pfam02618 266940010587 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 266940010588 dimerization interface [polypeptide binding]; other site 266940010589 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 266940010590 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 266940010591 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 266940010592 shikimate binding site; other site 266940010593 NAD(P) binding site [chemical binding]; other site 266940010594 LGFP repeat; Region: LGFP; pfam08310 266940010595 LGFP repeat; Region: LGFP; pfam08310 266940010596 LGFP repeat; Region: LGFP; pfam08310 266940010597 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 266940010598 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 266940010599 Walker A motif; other site 266940010600 ATP binding site [chemical binding]; other site 266940010601 Walker B motif; other site 266940010602 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 266940010603 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 266940010604 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 266940010605 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 266940010606 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 266940010607 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 266940010608 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 266940010609 PilX N-terminal; Region: PilX_N; pfam14341 266940010610 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 266940010611 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 266940010612 Competence protein A; Region: Competence_A; pfam11104 266940010613 Cell division protein FtsA; Region: FtsA; pfam14450 266940010614 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 266940010615 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 266940010616 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 266940010617 NPCBM/NEW2 domain; Region: NPCBM; cl07060 266940010618 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 266940010619 Shikimate kinase; Region: SKI; pfam01202 266940010620 ADP binding site [chemical binding]; other site 266940010621 magnesium binding site [ion binding]; other site 266940010622 putative shikimate binding site; other site 266940010623 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 266940010624 active site 266940010625 dimer interface [polypeptide binding]; other site 266940010626 metal binding site [ion binding]; metal-binding site 266940010627 elongation factor P; Validated; Region: PRK00529 266940010628 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 266940010629 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 266940010630 RNA binding site [nucleotide binding]; other site 266940010631 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 266940010632 RNA binding site [nucleotide binding]; other site 266940010633 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 266940010634 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266940010635 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266940010636 non-specific DNA binding site [nucleotide binding]; other site 266940010637 salt bridge; other site 266940010638 sequence-specific DNA binding site [nucleotide binding]; other site 266940010639 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 266940010640 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 266940010641 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 266940010642 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 266940010643 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 266940010644 dihydroorotase; Validated; Region: pyrC; PRK09357 266940010645 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266940010646 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 266940010647 active site 266940010648 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 266940010649 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 266940010650 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 266940010651 catalytic site [active] 266940010652 subunit interface [polypeptide binding]; other site 266940010653 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 266940010654 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266940010655 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 266940010656 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 266940010657 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266940010658 ATP-grasp domain; Region: ATP-grasp_4; cl17255 266940010659 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 266940010660 IMP binding site; other site 266940010661 dimer interface [polypeptide binding]; other site 266940010662 interdomain contacts; other site 266940010663 partial ornithine binding site; other site 266940010664 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 266940010665 active site 266940010666 dimer interface [polypeptide binding]; other site 266940010667 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266940010668 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 266940010669 peptide binding site [polypeptide binding]; other site 266940010670 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266940010671 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940010672 dimer interface [polypeptide binding]; other site 266940010673 ABC-ATPase subunit interface; other site 266940010674 putative PBP binding loops; other site 266940010675 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 266940010676 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940010677 putative PBP binding loops; other site 266940010678 dimer interface [polypeptide binding]; other site 266940010679 ABC-ATPase subunit interface; other site 266940010680 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 266940010681 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266940010682 Walker A/P-loop; other site 266940010683 ATP binding site [chemical binding]; other site 266940010684 Q-loop/lid; other site 266940010685 ABC transporter signature motif; other site 266940010686 Walker B; other site 266940010687 D-loop; other site 266940010688 H-loop/switch region; other site 266940010689 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 266940010690 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 266940010691 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266940010692 Walker A/P-loop; other site 266940010693 ATP binding site [chemical binding]; other site 266940010694 Q-loop/lid; other site 266940010695 ABC transporter signature motif; other site 266940010696 Walker B; other site 266940010697 D-loop; other site 266940010698 H-loop/switch region; other site 266940010699 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266940010700 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 266940010701 Guanylate kinase; Region: Guanylate_kin; pfam00625 266940010702 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 266940010703 catalytic site [active] 266940010704 G-X2-G-X-G-K; other site 266940010705 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 266940010706 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 266940010707 Flavoprotein; Region: Flavoprotein; pfam02441 266940010708 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 266940010709 S-adenosylmethionine synthetase; Validated; Region: PRK05250 266940010710 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 266940010711 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 266940010712 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 266940010713 primosome assembly protein PriA; Provisional; Region: PRK14873 266940010714 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266940010715 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266940010716 active site 266940010717 catalytic tetrad [active] 266940010718 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 266940010719 active site 266940010720 catalytic residues [active] 266940010721 metal binding site [ion binding]; metal-binding site 266940010722 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 266940010723 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 266940010724 putative active site [active] 266940010725 substrate binding site [chemical binding]; other site 266940010726 putative cosubstrate binding site; other site 266940010727 catalytic site [active] 266940010728 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 266940010729 substrate binding site [chemical binding]; other site 266940010730 16S rRNA methyltransferase B; Provisional; Region: PRK14902 266940010731 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 266940010732 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266940010733 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 266940010734 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 266940010735 tetramer interface [polypeptide binding]; other site 266940010736 active site 266940010737 Mg2+/Mn2+ binding site [ion binding]; other site 266940010738 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 266940010739 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 266940010740 active site 266940010741 substrate binding site [chemical binding]; other site 266940010742 FMN binding site [chemical binding]; other site 266940010743 putative catalytic residues [active] 266940010744 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 266940010745 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 266940010746 substrate binding site [chemical binding]; other site 266940010747 hexamer interface [polypeptide binding]; other site 266940010748 metal binding site [ion binding]; metal-binding site 266940010749 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 266940010750 Lumazine binding domain; Region: Lum_binding; pfam00677 266940010751 Lumazine binding domain; Region: Lum_binding; pfam00677 266940010752 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 266940010753 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 266940010754 homopentamer interface [polypeptide binding]; other site 266940010755 active site 266940010756 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 266940010757 metal binding site [ion binding]; metal-binding site 266940010758 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 266940010759 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 266940010760 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 266940010761 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 266940010762 hypothetical protein; Provisional; Region: PRK06547 266940010763 hypothetical protein; Provisional; Region: PRK01346 266940010764 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 266940010765 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 266940010766 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 266940010767 substrate binding site [chemical binding]; other site 266940010768 glutamase interaction surface [polypeptide binding]; other site 266940010769 TIGR03085 family protein; Region: TIGR03085 266940010770 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 266940010771 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 266940010772 active site 266940010773 ribulose/triose binding site [chemical binding]; other site 266940010774 phosphate binding site [ion binding]; other site 266940010775 substrate (anthranilate) binding pocket [chemical binding]; other site 266940010776 product (indole) binding pocket [chemical binding]; other site 266940010777 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 266940010778 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 266940010779 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266940010780 catalytic residue [active] 266940010781 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 266940010782 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 266940010783 substrate binding site [chemical binding]; other site 266940010784 active site 266940010785 catalytic residues [active] 266940010786 heterodimer interface [polypeptide binding]; other site 266940010787 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 266940010788 catalytic residues [active] 266940010789 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 266940010790 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 266940010791 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 266940010792 active site 266940010793 dimer interface [polypeptide binding]; other site 266940010794 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 266940010795 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 266940010796 active site 266940010797 FMN binding site [chemical binding]; other site 266940010798 substrate binding site [chemical binding]; other site 266940010799 3Fe-4S cluster binding site [ion binding]; other site 266940010800 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 266940010801 domain interface; other site 266940010802 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 266940010803 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266940010804 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 266940010805 pyruvate kinase; Provisional; Region: PRK06247 266940010806 domain interfaces; other site 266940010807 active site 266940010808 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 266940010809 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266940010810 active site 266940010811 phosphorylation site [posttranslational modification] 266940010812 intermolecular recognition site; other site 266940010813 dimerization interface [polypeptide binding]; other site 266940010814 ANTAR domain; Region: ANTAR; pfam03861 266940010815 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266940010816 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 266940010817 dimerization interface [polypeptide binding]; other site 266940010818 ligand binding site [chemical binding]; other site 266940010819 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266940010820 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266940010821 TM-ABC transporter signature motif; other site 266940010822 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266940010823 TM-ABC transporter signature motif; other site 266940010824 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266940010825 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 266940010826 Walker A/P-loop; other site 266940010827 ATP binding site [chemical binding]; other site 266940010828 Q-loop/lid; other site 266940010829 ABC transporter signature motif; other site 266940010830 Walker B; other site 266940010831 D-loop; other site 266940010832 H-loop/switch region; other site 266940010833 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266940010834 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 266940010835 Walker A/P-loop; other site 266940010836 ATP binding site [chemical binding]; other site 266940010837 Q-loop/lid; other site 266940010838 ABC transporter signature motif; other site 266940010839 Walker B; other site 266940010840 D-loop; other site 266940010841 H-loop/switch region; other site 266940010842 DNA polymerase I; Provisional; Region: PRK05755 266940010843 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 266940010844 active site 266940010845 metal binding site 1 [ion binding]; metal-binding site 266940010846 putative 5' ssDNA interaction site; other site 266940010847 metal binding site 3; metal-binding site 266940010848 metal binding site 2 [ion binding]; metal-binding site 266940010849 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 266940010850 putative DNA binding site [nucleotide binding]; other site 266940010851 putative metal binding site [ion binding]; other site 266940010852 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 266940010853 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 266940010854 active site 266940010855 DNA binding site [nucleotide binding] 266940010856 catalytic site [active] 266940010857 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940010858 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940010859 metal binding site [ion binding]; metal-binding site 266940010860 active site 266940010861 I-site; other site 266940010862 Methyltransferase domain; Region: Methyltransf_31; pfam13847 266940010863 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266940010864 S-adenosylmethionine binding site [chemical binding]; other site 266940010865 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 266940010866 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 266940010867 RNA binding site [nucleotide binding]; other site 266940010868 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 266940010869 RNA binding site [nucleotide binding]; other site 266940010870 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 266940010871 RNA binding site [nucleotide binding]; other site 266940010872 S1 RNA binding domain; Region: S1; pfam00575 266940010873 RNA binding site [nucleotide binding]; other site 266940010874 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266940010875 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266940010876 DNA binding site [nucleotide binding] 266940010877 domain linker motif; other site 266940010878 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 266940010879 ligand binding site [chemical binding]; other site 266940010880 dimerization interface (open form) [polypeptide binding]; other site 266940010881 dimerization interface (closed form) [polypeptide binding]; other site 266940010882 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 266940010883 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 266940010884 putative ligand binding site [chemical binding]; other site 266940010885 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 266940010886 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266940010887 Walker A/P-loop; other site 266940010888 ATP binding site [chemical binding]; other site 266940010889 Q-loop/lid; other site 266940010890 ABC transporter signature motif; other site 266940010891 Walker B; other site 266940010892 D-loop; other site 266940010893 H-loop/switch region; other site 266940010894 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266940010895 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266940010896 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266940010897 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266940010898 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266940010899 TM-ABC transporter signature motif; other site 266940010900 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 266940010901 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 266940010902 CoA-binding site [chemical binding]; other site 266940010903 ATP-binding [chemical binding]; other site 266940010904 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 266940010905 excinuclease ABC subunit B; Provisional; Region: PRK05298 266940010906 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266940010907 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266940010908 nucleotide binding region [chemical binding]; other site 266940010909 ATP-binding site [chemical binding]; other site 266940010910 Ultra-violet resistance protein B; Region: UvrB; pfam12344 266940010911 UvrB/uvrC motif; Region: UVR; pfam02151 266940010912 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266940010913 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 266940010914 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 266940010915 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 266940010916 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 266940010917 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 266940010918 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 266940010919 hypothetical protein; Provisional; Region: PRK07208 266940010920 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266940010921 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 266940010922 active site 266940010923 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 266940010924 homodimer interface [polypeptide binding]; other site 266940010925 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 266940010926 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 266940010927 GIY-YIG motif/motif A; other site 266940010928 active site 266940010929 catalytic site [active] 266940010930 putative DNA binding site [nucleotide binding]; other site 266940010931 metal binding site [ion binding]; metal-binding site 266940010932 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 266940010933 Helix-hairpin-helix motif; Region: HHH; pfam00633 266940010934 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 266940010935 shikimate kinase; Reviewed; Region: aroK; PRK00131 266940010936 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cl00425 266940010937 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 266940010938 dimer interface [polypeptide binding]; other site 266940010939 phosphate binding site [ion binding]; other site 266940010940 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 266940010941 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 266940010942 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 266940010943 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 266940010944 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 266940010945 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 266940010946 Phosphoglycerate kinase; Region: PGK; pfam00162 266940010947 substrate binding site [chemical binding]; other site 266940010948 hinge regions; other site 266940010949 ADP binding site [chemical binding]; other site 266940010950 catalytic site [active] 266940010951 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 266940010952 triosephosphate isomerase; Provisional; Region: PRK14567 266940010953 substrate binding site [chemical binding]; other site 266940010954 dimer interface [polypeptide binding]; other site 266940010955 catalytic triad [active] 266940010956 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 266940010957 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 266940010958 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 266940010959 putative active site [active] 266940010960 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 266940010961 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 266940010962 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 266940010963 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 266940010964 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 266940010965 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 266940010966 putative active site [active] 266940010967 transaldolase; Provisional; Region: PRK03903 266940010968 catalytic residue [active] 266940010969 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 266940010970 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 266940010971 TPP-binding site [chemical binding]; other site 266940010972 dimer interface [polypeptide binding]; other site 266940010973 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 266940010974 PYR/PP interface [polypeptide binding]; other site 266940010975 dimer interface [polypeptide binding]; other site 266940010976 TPP binding site [chemical binding]; other site 266940010977 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 266940010978 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 266940010979 UbiA prenyltransferase family; Region: UbiA; pfam01040 266940010980 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 266940010981 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940010982 Walker A/P-loop; other site 266940010983 ATP binding site [chemical binding]; other site 266940010984 Q-loop/lid; other site 266940010985 ABC transporter signature motif; other site 266940010986 Walker B; other site 266940010987 D-loop; other site 266940010988 H-loop/switch region; other site 266940010989 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 266940010990 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 266940010991 putative DNA binding site [nucleotide binding]; other site 266940010992 putative Zn2+ binding site [ion binding]; other site 266940010993 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 266940010994 FeS assembly protein SufB; Region: sufB; TIGR01980 266940010995 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 266940010996 FeS assembly protein SufD; Region: sufD; TIGR01981 266940010997 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 266940010998 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 266940010999 Walker A/P-loop; other site 266940011000 ATP binding site [chemical binding]; other site 266940011001 Q-loop/lid; other site 266940011002 ABC transporter signature motif; other site 266940011003 Walker B; other site 266940011004 D-loop; other site 266940011005 H-loop/switch region; other site 266940011006 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 266940011007 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 266940011008 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 266940011009 Walker A/P-loop; other site 266940011010 ATP binding site [chemical binding]; other site 266940011011 Q-loop/lid; other site 266940011012 ABC transporter signature motif; other site 266940011013 Walker B; other site 266940011014 D-loop; other site 266940011015 H-loop/switch region; other site 266940011016 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 266940011017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940011018 Walker A/P-loop; other site 266940011019 ATP binding site [chemical binding]; other site 266940011020 Q-loop/lid; other site 266940011021 ABC transporter signature motif; other site 266940011022 Walker B; other site 266940011023 D-loop; other site 266940011024 H-loop/switch region; other site 266940011025 ABC transporter; Region: ABC_tran_2; pfam12848 266940011026 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266940011027 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 266940011028 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 266940011029 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940011030 NAD(P) binding site [chemical binding]; other site 266940011031 active site 266940011032 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 266940011033 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 266940011034 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940011035 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 266940011036 NAD(P) binding site [chemical binding]; other site 266940011037 active site 266940011038 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 266940011039 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 266940011040 phosphoserine phosphatase SerB; Region: serB; TIGR00338 266940011041 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266940011042 motif II; other site 266940011043 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 266940011044 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 266940011045 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 266940011046 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 266940011047 ligand binding site; other site 266940011048 oligomer interface; other site 266940011049 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 266940011050 dimer interface [polypeptide binding]; other site 266940011051 N-terminal domain interface [polypeptide binding]; other site 266940011052 sulfate 1 binding site; other site 266940011053 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 266940011054 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 266940011055 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 266940011056 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 266940011057 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940011058 Walker A/P-loop; other site 266940011059 ATP binding site [chemical binding]; other site 266940011060 Q-loop/lid; other site 266940011061 ABC transporter signature motif; other site 266940011062 Walker B; other site 266940011063 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 266940011064 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266940011065 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266940011066 catalytic residue [active] 266940011067 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266940011068 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 266940011069 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 266940011070 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 266940011071 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 266940011072 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 266940011073 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 266940011074 Catalytic site [active] 266940011075 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266940011076 non-specific DNA binding site [nucleotide binding]; other site 266940011077 salt bridge; other site 266940011078 sequence-specific DNA binding site [nucleotide binding]; other site 266940011079 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266940011080 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 266940011081 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 266940011082 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 266940011083 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 266940011084 Right handed beta helix region; Region: Beta_helix; pfam13229 266940011085 Phytase; Region: Phytase; cl17685 266940011086 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 266940011087 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 266940011088 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 266940011089 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 266940011090 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940011091 TIGR01777 family protein; Region: yfcH 266940011092 NAD(P) binding site [chemical binding]; other site 266940011093 active site 266940011094 Predicted transcriptional regulator [Transcription]; Region: COG2378 266940011095 WYL domain; Region: WYL; pfam13280 266940011096 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 266940011097 dimer interface [polypeptide binding]; other site 266940011098 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266940011099 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 266940011100 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266940011101 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 266940011102 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 266940011103 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 266940011104 DNA binding site [nucleotide binding] 266940011105 active site 266940011106 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266940011107 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940011108 NAD(P) binding site [chemical binding]; other site 266940011109 active site 266940011110 MarR family; Region: MarR_2; pfam12802 266940011111 enterobactin exporter EntS; Provisional; Region: PRK10489 266940011112 stage V sporulation protein K; Region: spore_V_K; TIGR02881 266940011113 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266940011114 Walker A motif; other site 266940011115 ATP binding site [chemical binding]; other site 266940011116 Walker B motif; other site 266940011117 arginine finger; other site 266940011118 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 266940011119 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 266940011120 putative trimer interface [polypeptide binding]; other site 266940011121 putative CoA binding site [chemical binding]; other site 266940011122 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 266940011123 putative trimer interface [polypeptide binding]; other site 266940011124 putative CoA binding site [chemical binding]; other site 266940011125 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 266940011126 Cupin; Region: Cupin_6; pfam12852 266940011127 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266940011128 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266940011129 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940011130 NAD(P) binding site [chemical binding]; other site 266940011131 active site 266940011132 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266940011133 MarR family; Region: MarR; pfam01047 266940011134 Epoxide hydrolase N terminus; Region: EHN; pfam06441 266940011135 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266940011136 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 266940011137 Coenzyme A binding pocket [chemical binding]; other site 266940011138 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 266940011139 putative transposase OrfB; Reviewed; Region: PHA02517 266940011140 HTH-like domain; Region: HTH_21; pfam13276 266940011141 Integrase core domain; Region: rve; pfam00665 266940011142 Integrase core domain; Region: rve_3; cl15866 266940011143 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266940011144 Transposase; Region: HTH_Tnp_1; pfam01527 266940011145 Transposase; Region: HTH_Tnp_1; cl17663 266940011146 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 266940011147 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266940011148 ligand binding site [chemical binding]; other site 266940011149 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 266940011150 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266940011151 motif II; other site 266940011152 YCII-related domain; Region: YCII; cl00999 266940011153 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266940011154 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266940011155 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 266940011156 putative dimerization interface [polypeptide binding]; other site 266940011157 EamA-like transporter family; Region: EamA; pfam00892 266940011158 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 266940011159 homotrimer interaction site [polypeptide binding]; other site 266940011160 putative active site [active] 266940011161 Predicted transcriptional regulators [Transcription]; Region: COG1695 266940011162 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 266940011163 oxidoreductase; Provisional; Region: PRK12742 266940011164 classical (c) SDRs; Region: SDR_c; cd05233 266940011165 NAD(P) binding site [chemical binding]; other site 266940011166 active site 266940011167 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266940011168 Phosphotransferase enzyme family; Region: APH; pfam01636 266940011169 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 266940011170 oxidoreductase; Provisional; Region: PRK06128 266940011171 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 266940011172 NAD binding site [chemical binding]; other site 266940011173 metal binding site [ion binding]; metal-binding site 266940011174 active site 266940011175 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 266940011176 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 266940011177 malonyl-CoA binding site [chemical binding]; other site 266940011178 dimer interface [polypeptide binding]; other site 266940011179 active site 266940011180 product binding site; other site 266940011181 hypothetical protein; Provisional; Region: PRK06202 266940011182 FAD binding domain; Region: FAD_binding_3; pfam01494 266940011183 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266940011184 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266940011185 cyanate transporter; Region: CynX; TIGR00896 266940011186 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940011187 putative substrate translocation pore; other site 266940011188 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 266940011189 IHF - DNA interface [nucleotide binding]; other site 266940011190 IHF dimer interface [polypeptide binding]; other site 266940011191 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266940011192 salt bridge; other site 266940011193 non-specific DNA binding site [nucleotide binding]; other site 266940011194 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266940011195 sequence-specific DNA binding site [nucleotide binding]; other site 266940011196 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266940011197 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266940011198 active site 266940011199 phosphorylation site [posttranslational modification] 266940011200 intermolecular recognition site; other site 266940011201 dimerization interface [polypeptide binding]; other site 266940011202 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266940011203 DNA binding site [nucleotide binding] 266940011204 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266940011205 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266940011206 dimerization interface [polypeptide binding]; other site 266940011207 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266940011208 dimer interface [polypeptide binding]; other site 266940011209 phosphorylation site [posttranslational modification] 266940011210 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266940011211 ATP binding site [chemical binding]; other site 266940011212 Mg2+ binding site [ion binding]; other site 266940011213 G-X-G motif; other site 266940011214 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 266940011215 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266940011216 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 266940011217 putative ADP-binding pocket [chemical binding]; other site 266940011218 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266940011219 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266940011220 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266940011221 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940011222 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 266940011223 Walker A/P-loop; other site 266940011224 ATP binding site [chemical binding]; other site 266940011225 Q-loop/lid; other site 266940011226 ABC transporter signature motif; other site 266940011227 Walker B; other site 266940011228 D-loop; other site 266940011229 H-loop/switch region; other site 266940011230 Phosphotransferase enzyme family; Region: APH; pfam01636 266940011231 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 266940011232 active site 266940011233 ATP binding site [chemical binding]; other site 266940011234 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 266940011235 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 266940011236 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266940011237 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266940011238 short chain dehydrogenase; Provisional; Region: PRK06197 266940011239 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 266940011240 putative NAD(P) binding site [chemical binding]; other site 266940011241 active site 266940011242 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 266940011243 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 266940011244 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 266940011245 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940011246 Walker A/P-loop; other site 266940011247 ATP binding site [chemical binding]; other site 266940011248 Q-loop/lid; other site 266940011249 ABC transporter signature motif; other site 266940011250 Walker B; other site 266940011251 D-loop; other site 266940011252 H-loop/switch region; other site 266940011253 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 266940011254 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 266940011255 active site 266940011256 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 266940011257 nucleophile elbow; other site 266940011258 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 266940011259 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 266940011260 putative NAD(P) binding site [chemical binding]; other site 266940011261 dimer interface [polypeptide binding]; other site 266940011262 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940011263 NAD(P) binding site [chemical binding]; other site 266940011264 active site 266940011265 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940011266 putative substrate translocation pore; other site 266940011267 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266940011268 MarR family; Region: MarR; pfam01047 266940011269 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 266940011270 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 266940011271 active site 266940011272 metal binding site [ion binding]; metal-binding site 266940011273 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 266940011274 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 266940011275 Active site serine [active] 266940011276 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 266940011277 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266940011278 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940011279 metal binding site [ion binding]; metal-binding site 266940011280 active site 266940011281 I-site; other site 266940011282 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266940011283 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 266940011284 catalytic residues [active] 266940011285 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 266940011286 TPR repeat; Region: TPR_11; pfam13414 266940011287 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266940011288 binding surface 266940011289 TPR motif; other site 266940011290 TPR repeat; Region: TPR_11; pfam13414 266940011291 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 266940011292 YCII-related domain; Region: YCII; cl00999 266940011293 Phosphotransferase enzyme family; Region: APH; pfam01636 266940011294 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 266940011295 active site 266940011296 ATP binding site [chemical binding]; other site 266940011297 substrate binding site [chemical binding]; other site 266940011298 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266940011299 S-adenosylmethionine binding site [chemical binding]; other site 266940011300 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 266940011301 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 266940011302 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266940011303 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266940011304 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266940011305 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 266940011306 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266940011307 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940011308 dimer interface [polypeptide binding]; other site 266940011309 conserved gate region; other site 266940011310 putative PBP binding loops; other site 266940011311 ABC-ATPase subunit interface; other site 266940011312 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266940011313 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940011314 putative PBP binding loops; other site 266940011315 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 266940011316 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266940011317 Walker A/P-loop; other site 266940011318 ATP binding site [chemical binding]; other site 266940011319 Q-loop/lid; other site 266940011320 ABC transporter signature motif; other site 266940011321 Walker B; other site 266940011322 D-loop; other site 266940011323 H-loop/switch region; other site 266940011324 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266940011325 Walker A/P-loop; other site 266940011326 ATP binding site [chemical binding]; other site 266940011327 Q-loop/lid; other site 266940011328 ABC transporter signature motif; other site 266940011329 Walker B; other site 266940011330 D-loop; other site 266940011331 H-loop/switch region; other site 266940011332 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 266940011333 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 266940011334 CMD domain protein, Avi_7170 family; Region: CMD_Avi_7170; TIGR04029 266940011335 alkylhydroperoxidase domain protein, Avi_7169 family; Region: perox_Avi_7169; TIGR04030 266940011336 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 266940011337 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 266940011338 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266940011339 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266940011340 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 266940011341 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 266940011342 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 266940011343 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 266940011344 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266940011345 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 266940011346 ligand binding site [chemical binding]; other site 266940011347 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940011348 metal binding site [ion binding]; metal-binding site 266940011349 active site 266940011350 I-site; other site 266940011351 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266940011352 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940011353 NAD(P) binding site [chemical binding]; other site 266940011354 active site 266940011355 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 266940011356 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266940011357 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266940011358 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 266940011359 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 266940011360 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 266940011361 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 266940011362 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 266940011363 DNA binding residues [nucleotide binding] 266940011364 drug binding residues [chemical binding]; other site 266940011365 dimer interface [polypeptide binding]; other site 266940011366 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 266940011367 SnoaL-like domain; Region: SnoaL_2; pfam12680 266940011368 short chain dehydrogenase; Provisional; Region: PRK06523 266940011369 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940011370 NAD(P) binding site [chemical binding]; other site 266940011371 active site 266940011372 Lsr2; Region: Lsr2; pfam11774 266940011373 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 266940011374 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266940011375 AAA ATPase domain; Region: AAA_16; pfam13191 266940011376 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266940011377 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266940011378 DNA binding residues [nucleotide binding] 266940011379 dimerization interface [polypeptide binding]; other site 266940011380 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266940011381 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266940011382 choline dehydrogenase; Validated; Region: PRK02106 266940011383 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266940011384 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 266940011385 Isochorismatase family; Region: Isochorismatase; pfam00857 266940011386 catalytic triad [active] 266940011387 conserved cis-peptide bond; other site 266940011388 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 266940011389 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 266940011390 conserved cys residue [active] 266940011391 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266940011392 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 266940011393 Predicted amidohydrolase [General function prediction only]; Region: COG0388 266940011394 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 266940011395 putative active site [active] 266940011396 catalytic triad [active] 266940011397 putative dimer interface [polypeptide binding]; other site 266940011398 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 266940011399 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266940011400 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940011401 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 266940011402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940011403 putative substrate translocation pore; other site 266940011404 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 266940011405 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 266940011406 catalytic Zn binding site [ion binding]; other site 266940011407 NAD(P) binding site [chemical binding]; other site 266940011408 structural Zn binding site [ion binding]; other site 266940011409 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 266940011410 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 266940011411 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 266940011412 putative NAD(P) binding site [chemical binding]; other site 266940011413 putative substrate binding site [chemical binding]; other site 266940011414 catalytic Zn binding site [ion binding]; other site 266940011415 structural Zn binding site [ion binding]; other site 266940011416 dimer interface [polypeptide binding]; other site 266940011417 Uncharacterized conserved protein [Function unknown]; Region: COG4925 266940011418 L-idonate 5-dehydrogenase; Region: PLN02702 266940011419 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 266940011420 inhibitor binding site; inhibition site 266940011421 catalytic Zn binding site [ion binding]; other site 266940011422 structural Zn binding site [ion binding]; other site 266940011423 NADP binding site [chemical binding]; other site 266940011424 tetramer interface [polypeptide binding]; other site 266940011425 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940011426 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266940011427 NAD(P) binding site [chemical binding]; other site 266940011428 active site 266940011429 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 266940011430 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266940011431 Helix-turn-helix domain; Region: HTH_18; pfam12833 266940011432 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266940011433 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266940011434 active site 266940011435 catalytic tetrad [active] 266940011436 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266940011437 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266940011438 active site 266940011439 catalytic tetrad [active] 266940011440 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 266940011441 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 266940011442 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 266940011443 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266940011444 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266940011445 DNA binding site [nucleotide binding] 266940011446 domain linker motif; other site 266940011447 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940011448 NAD(P) binding site [chemical binding]; other site 266940011449 active site 266940011450 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 266940011451 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 266940011452 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 266940011453 LGFP repeat; Region: LGFP; pfam08310 266940011454 LGFP repeat; Region: LGFP; pfam08310 266940011455 LGFP repeat; Region: LGFP; pfam08310 266940011456 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 266940011457 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266940011458 putative NAD(P) binding site [chemical binding]; other site 266940011459 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 266940011460 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 266940011461 dimer interface [polypeptide binding]; other site 266940011462 ADP-ribose binding site [chemical binding]; other site 266940011463 active site 266940011464 nudix motif; other site 266940011465 metal binding site [ion binding]; metal-binding site 266940011466 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 266940011467 active site clefts [active] 266940011468 zinc binding site [ion binding]; other site 266940011469 dimer interface [polypeptide binding]; other site 266940011470 Domain of unknown function (DUF4375); Region: DUF4375; pfam14300 266940011471 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 266940011472 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 266940011473 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 266940011474 putative active site [active] 266940011475 putative metal binding site [ion binding]; other site 266940011476 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 266940011477 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 266940011478 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 266940011479 CGNR zinc finger; Region: zf-CGNR; pfam11706 266940011480 Epoxide hydrolase N terminus; Region: EHN; pfam06441 266940011481 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266940011482 Epoxide hydrolase N terminus; Region: EHN; pfam06441 266940011483 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266940011484 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 266940011485 active site 266940011486 metal binding site [ion binding]; metal-binding site 266940011487 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 266940011488 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 266940011489 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 266940011490 NADP+ binding site [chemical binding]; other site 266940011491 folate binding site [chemical binding]; other site 266940011492 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 266940011493 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266940011494 DNA-binding site [nucleotide binding]; DNA binding site 266940011495 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 266940011496 FCD domain; Region: FCD; pfam07729 266940011497 Fic/DOC family; Region: Fic; cl00960 266940011498 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 266940011499 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 266940011500 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 266940011501 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 266940011502 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 266940011503 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 266940011504 siderophore binding site; other site 266940011505 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 266940011506 homotrimer interaction site [polypeptide binding]; other site 266940011507 putative active site [active] 266940011508 RibD C-terminal domain; Region: RibD_C; cl17279 266940011509 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 266940011510 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 266940011511 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 266940011512 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 266940011513 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 266940011514 MMPL family; Region: MMPL; pfam03176 266940011515 MMPL family; Region: MMPL; pfam03176 266940011516 Histidine kinase; Region: HisKA_3; pfam07730 266940011517 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 266940011518 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266940011519 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266940011520 active site 266940011521 phosphorylation site [posttranslational modification] 266940011522 intermolecular recognition site; other site 266940011523 dimerization interface [polypeptide binding]; other site 266940011524 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266940011525 DNA binding residues [nucleotide binding] 266940011526 dimerization interface [polypeptide binding]; other site 266940011527 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 266940011528 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266940011529 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940011530 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 266940011531 NAD(P) binding site [chemical binding]; other site 266940011532 active site 266940011533 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 266940011534 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 266940011535 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 266940011536 putative active site [active] 266940011537 metal binding site [ion binding]; metal-binding site 266940011538 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266940011539 MarR family; Region: MarR; pfam01047 266940011540 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266940011541 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266940011542 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266940011543 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 266940011544 Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406 266940011545 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 266940011546 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 266940011547 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266940011548 active site 266940011549 metal binding site [ion binding]; metal-binding site 266940011550 Domain of unknown function (DUF4279); Region: DUF4279; pfam14106 266940011551 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266940011552 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266940011553 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 266940011554 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266940011555 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266940011556 DNA binding residues [nucleotide binding] 266940011557 HTH domain; Region: HTH_11; pfam08279 266940011558 WYL domain; Region: WYL; pfam13280 266940011559 hypothetical protein; Provisional; Region: PRK07236 266940011560 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 266940011561 Beta-lactamase; Region: Beta-lactamase; pfam00144 266940011562 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 266940011563 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 266940011564 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 266940011565 putative NAD(P) binding site [chemical binding]; other site 266940011566 putative substrate binding site [chemical binding]; other site 266940011567 catalytic Zn binding site [ion binding]; other site 266940011568 structural Zn binding site [ion binding]; other site 266940011569 dimer interface [polypeptide binding]; other site 266940011570 glycogen branching enzyme; Provisional; Region: PRK14705 266940011571 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 266940011572 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 266940011573 Lsr2; Region: Lsr2; pfam11774 266940011574 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 266940011575 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266940011576 substrate binding site [chemical binding]; other site 266940011577 oxyanion hole (OAH) forming residues; other site 266940011578 trimer interface [polypeptide binding]; other site 266940011579 Predicted transcriptional regulators [Transcription]; Region: COG1733 266940011580 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 266940011581 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266940011582 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266940011583 WHG domain; Region: WHG; pfam13305 266940011584 CAAX protease self-immunity; Region: Abi; pfam02517 266940011585 Histidine kinase; Region: HisKA_3; pfam07730 266940011586 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 266940011587 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266940011588 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266940011589 active site 266940011590 phosphorylation site [posttranslational modification] 266940011591 intermolecular recognition site; other site 266940011592 dimerization interface [polypeptide binding]; other site 266940011593 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266940011594 DNA binding residues [nucleotide binding] 266940011595 dimerization interface [polypeptide binding]; other site 266940011596 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266940011597 classical (c) SDRs; Region: SDR_c; cd05233 266940011598 NAD(P) binding site [chemical binding]; other site 266940011599 active site 266940011600 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266940011601 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940011602 NAD(P) binding site [chemical binding]; other site 266940011603 active site 266940011604 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266940011605 MarR family; Region: MarR_2; pfam12802 266940011606 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266940011607 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266940011608 non-specific DNA binding site [nucleotide binding]; other site 266940011609 salt bridge; other site 266940011610 sequence-specific DNA binding site [nucleotide binding]; other site 266940011611 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 266940011612 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266940011613 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266940011614 Methyltransferase domain; Region: Methyltransf_31; pfam13847 266940011615 S-adenosylmethionine binding site [chemical binding]; other site 266940011616 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 266940011617 classical (c) SDRs; Region: SDR_c; cd05233 266940011618 NAD(P) binding site [chemical binding]; other site 266940011619 active site 266940011620 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940011621 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940011622 metal binding site [ion binding]; metal-binding site 266940011623 active site 266940011624 I-site; other site 266940011625 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266940011626 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 266940011627 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266940011628 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266940011629 DNA binding site [nucleotide binding] 266940011630 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 266940011631 ligand binding site [chemical binding]; other site 266940011632 dimerization interface [polypeptide binding]; other site 266940011633 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 266940011634 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 266940011635 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266940011636 classical (c) SDRs; Region: SDR_c; cd05233 266940011637 NAD(P) binding site [chemical binding]; other site 266940011638 active site 266940011639 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266940011640 salt bridge; other site 266940011641 non-specific DNA binding site [nucleotide binding]; other site 266940011642 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266940011643 sequence-specific DNA binding site [nucleotide binding]; other site 266940011644 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266940011645 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266940011646 short chain dehydrogenase; Provisional; Region: PRK05854 266940011647 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940011648 NAD(P) binding site [chemical binding]; other site 266940011649 active site 266940011650 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 266940011651 Helix-turn-helix domain; Region: HTH_31; pfam13560 266940011652 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266940011653 sequence-specific DNA binding site [nucleotide binding]; other site 266940011654 salt bridge; other site 266940011655 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266940011656 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266940011657 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 266940011658 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940011659 NAD(P) binding site [chemical binding]; other site 266940011660 active site 266940011661 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266940011662 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266940011663 Foamy virus envelope protein; Region: Foamy_virus_ENV; pfam03408 266940011664 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 266940011665 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 266940011666 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 266940011667 7-cyano-7-deazaguanine tRNA-ribosyltransferase; Provisional; Region: PRK13534 266940011668 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 266940011669 Domain of unknown function DUF87; Region: DUF87; pfam01935 266940011670 AAA-like domain; Region: AAA_10; pfam12846 266940011671 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 266940011672 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 266940011673 active site 266940011674 metal binding site [ion binding]; metal-binding site 266940011675 DNA binding site [nucleotide binding] 266940011676 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 266940011677 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940011678 Walker A/P-loop; other site 266940011679 ATP binding site [chemical binding]; other site 266940011680 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 266940011681 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940011682 ABC transporter signature motif; other site 266940011683 Walker B; other site 266940011684 D-loop; other site 266940011685 H-loop/switch region; other site 266940011686 Plasmid encoded RepA protein; Region: RepA_C; pfam04796 266940011687 Plasmid encoded RepA protein; Region: RepA_C; pfam04796 266940011688 Lsr2; Region: Lsr2; pfam11774 266940011689 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 266940011690 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 266940011691 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266940011692 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266940011693 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 266940011694 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266940011695 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940011696 dimer interface [polypeptide binding]; other site 266940011697 conserved gate region; other site 266940011698 putative PBP binding loops; other site 266940011699 ABC-ATPase subunit interface; other site 266940011700 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266940011701 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940011702 dimer interface [polypeptide binding]; other site 266940011703 conserved gate region; other site 266940011704 putative PBP binding loops; other site 266940011705 ABC-ATPase subunit interface; other site 266940011706 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 266940011707 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266940011708 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266940011709 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 266940011710 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 266940011711 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 266940011712 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 266940011713 Histidine kinase; Region: HisKA_3; pfam07730 266940011714 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 266940011715 ATP binding site [chemical binding]; other site 266940011716 Mg2+ binding site [ion binding]; other site 266940011717 G-X-G motif; other site 266940011718 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266940011719 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266940011720 active site 266940011721 phosphorylation site [posttranslational modification] 266940011722 intermolecular recognition site; other site 266940011723 dimerization interface [polypeptide binding]; other site 266940011724 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266940011725 dimerization interface [polypeptide binding]; other site 266940011726 DNA binding residues [nucleotide binding] 266940011727 MMPL family; Region: MMPL; pfam03176 266940011728 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940011729 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266940011730 putative substrate translocation pore; other site 266940011731 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940011732 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 266940011733 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 266940011734 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 266940011735 inhibitor binding site; inhibition site 266940011736 active site 266940011737 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 266940011738 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 266940011739 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 266940011740 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 266940011741 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 266940011742 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 266940011743 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 266940011744 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266940011745 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266940011746 DNA binding site [nucleotide binding] 266940011747 domain linker motif; other site 266940011748 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 266940011749 ligand binding site [chemical binding]; other site 266940011750 dimerization interface [polypeptide binding]; other site 266940011751 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940011752 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266940011753 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 266940011754 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 266940011755 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 266940011756 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 266940011757 beta-galactosidase; Region: BGL; TIGR03356 266940011758 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 266940011759 classical (c) SDRs; Region: SDR_c; cd05233 266940011760 NAD(P) binding site [chemical binding]; other site 266940011761 active site 266940011762 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 266940011763 Cytochrome P450; Region: p450; cl12078 266940011764 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 266940011765 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 266940011766 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 266940011767 Histidine kinase; Region: HisKA_3; pfam07730 266940011768 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 266940011769 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266940011770 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266940011771 active site 266940011772 phosphorylation site [posttranslational modification] 266940011773 intermolecular recognition site; other site 266940011774 dimerization interface [polypeptide binding]; other site 266940011775 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266940011776 DNA binding residues [nucleotide binding] 266940011777 dimerization interface [polypeptide binding]; other site 266940011778 Protein of unknown function (DUF418); Region: DUF418; pfam04235 266940011779 Restriction endonuclease; Region: Mrr_cat; pfam04471 266940011780 short chain dehydrogenase; Provisional; Region: PRK05854 266940011781 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940011782 NAD(P) binding site [chemical binding]; other site 266940011783 active site 266940011784 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 266940011785 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940011786 NAD(P) binding site [chemical binding]; other site 266940011787 active site 266940011788 acyltransferase PapA5; Provisional; Region: PRK09294 266940011789 classical (c) SDRs; Region: SDR_c; cd05233 266940011790 NAD(P) binding site [chemical binding]; other site 266940011791 active site 266940011792 shikimate transporter; Provisional; Region: PRK09952 266940011793 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940011794 putative substrate translocation pore; other site 266940011795 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 266940011796 histidinol dehydrogenase; Region: hisD; TIGR00069 266940011797 NAD binding site [chemical binding]; other site 266940011798 dimerization interface [polypeptide binding]; other site 266940011799 product binding site; other site 266940011800 substrate binding site [chemical binding]; other site 266940011801 zinc binding site [ion binding]; other site 266940011802 catalytic residues [active] 266940011803 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266940011804 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266940011805 DNA binding site [nucleotide binding] 266940011806 domain linker motif; other site 266940011807 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 266940011808 dimerization interface [polypeptide binding]; other site 266940011809 ligand binding site [chemical binding]; other site 266940011810 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 266940011811 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 266940011812 NAD(P) binding site [chemical binding]; other site 266940011813 Plasmid encoded RepA protein; Region: RepA_C; pfam04796 266940011814 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 266940011815 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 266940011816 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266940011817 active site 266940011818 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 266940011819 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266940011820 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266940011821 DNA-binding site [nucleotide binding]; DNA binding site 266940011822 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 266940011823 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 266940011824 Citrate transporter; Region: CitMHS; pfam03600 266940011825 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 266940011826 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 266940011827 tartrate dehydrogenase; Provisional; Region: PRK08194 266940011828 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177 266940011829 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 266940011830 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 266940011831 intersubunit interface [polypeptide binding]; other site 266940011832 active site 266940011833 Zn2+ binding site [ion binding]; other site 266940011834 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266940011835 Ligand Binding Site [chemical binding]; other site 266940011836 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 266940011837 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 266940011838 putative active site [active] 266940011839 TM1410 hypothetical-related protein; Region: DUF297; cl00997 266940011840 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266940011841 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266940011842 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940011843 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266940011844 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 266940011845 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 266940011846 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 266940011847 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 266940011848 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 266940011849 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266940011850 hypothetical protein; Provisional; Region: PRK07236 266940011851 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 266940011852 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266940011853 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 266940011854 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 266940011855 NAD binding site [chemical binding]; other site 266940011856 substrate binding site [chemical binding]; other site 266940011857 catalytic Zn binding site [ion binding]; other site 266940011858 structural Zn binding site [ion binding]; other site 266940011859 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266940011860 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266940011861 non-specific DNA binding site [nucleotide binding]; other site 266940011862 salt bridge; other site 266940011863 sequence-specific DNA binding site [nucleotide binding]; other site 266940011864 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 266940011865 classical (c) SDRs; Region: SDR_c; cd05233 266940011866 NAD(P) binding site [chemical binding]; other site 266940011867 active site 266940011868 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266940011869 dimerization interface [polypeptide binding]; other site 266940011870 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 266940011871 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266940011872 dimer interface [polypeptide binding]; other site 266940011873 putative CheW interface [polypeptide binding]; other site 266940011874 GAF domain; Region: GAF_2; pfam13185 266940011875 ANTAR domain; Region: ANTAR; pfam03861 266940011876 Transposase; Region: HTH_Tnp_1; cl17663 266940011877 GAF domain; Region: GAF; pfam01590 266940011878 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 266940011879 PAS domain; Region: PAS; smart00091 266940011880 PAS domain; Region: PAS_9; pfam13426 266940011881 GAF domain; Region: GAF_3; pfam13492 266940011882 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940011883 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940011884 metal binding site [ion binding]; metal-binding site 266940011885 active site 266940011886 I-site; other site 266940011887 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266940011888 PAS fold; Region: PAS_3; pfam08447 266940011889 putative active site [active] 266940011890 heme pocket [chemical binding]; other site 266940011891 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266940011892 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266940011893 DNA binding residues [nucleotide binding] 266940011894 dimerization interface [polypeptide binding]; other site 266940011895 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940011896 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940011897 metal binding site [ion binding]; metal-binding site 266940011898 active site 266940011899 I-site; other site 266940011900 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266940011901 PAS domain S-box; Region: sensory_box; TIGR00229 266940011902 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266940011903 putative active site [active] 266940011904 heme pocket [chemical binding]; other site 266940011905 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940011906 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940011907 metal binding site [ion binding]; metal-binding site 266940011908 active site 266940011909 I-site; other site 266940011910 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266940011911 Protein of unknown function (DUF1059); Region: DUF1059; pfam06348 266940011912 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 266940011913 dimerization interface [polypeptide binding]; other site 266940011914 ligand binding site [chemical binding]; other site 266940011915 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266940011916 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266940011917 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266940011918 metal binding site [ion binding]; metal-binding site 266940011919 active site 266940011920 I-site; other site 266940011921 GAF domain; Region: GAF; pfam01590 266940011922 GAF domain; Region: GAF_2; pfam13185 266940011923 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 266940011924 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 266940011925 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 266940011926 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 266940011927 GAF domain; Region: GAF; cl17456 266940011928 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 266940011929 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 266940011930 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 266940011931 active site 266940011932 FMN binding site [chemical binding]; other site 266940011933 substrate binding site [chemical binding]; other site 266940011934 homotetramer interface [polypeptide binding]; other site 266940011935 catalytic residue [active] 266940011936 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266940011937 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266940011938 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 266940011939 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 266940011940 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 266940011941 putative hydrophobic ligand binding site [chemical binding]; other site 266940011942 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 266940011943 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 266940011944 DNA binding residues [nucleotide binding] 266940011945 dimer interface [polypeptide binding]; other site 266940011946 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 266940011947 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 266940011948 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 266940011949 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 266940011950 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940011951 NADH(P)-binding; Region: NAD_binding_10; pfam13460 266940011952 NAD(P) binding site [chemical binding]; other site 266940011953 active site 266940011954 Cupin; Region: Cupin_6; pfam12852 266940011955 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266940011956 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266940011957 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cl00236 266940011958 putative transposase OrfB; Reviewed; Region: PHA02517 266940011959 HTH-like domain; Region: HTH_21; pfam13276 266940011960 Integrase core domain; Region: rve; pfam00665 266940011961 Integrase core domain; Region: rve_3; cl15866 266940011962 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266940011963 Transposase; Region: HTH_Tnp_1; pfam01527 266940011964 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 266940011965 conserved cys residue [active] 266940011966 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 266940011967 active site 266940011968 catalytic motif [active] 266940011969 Zn binding site [ion binding]; other site 266940011970 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 266940011971 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 266940011972 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 266940011973 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 266940011974 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 266940011975 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266940011976 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266940011977 DNA binding residues [nucleotide binding] 266940011978 Phosphotransferase enzyme family; Region: APH; pfam01636 266940011979 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 266940011980 active site 266940011981 ATP binding site [chemical binding]; other site 266940011982 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 266940011983 Protein of unknown function (DUF2716); Region: DUF2716; pfam10898 266940011984 enterobactin exporter EntS; Provisional; Region: PRK10489 266940011985 MarR family; Region: MarR_2; cl17246 266940011986 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 266940011987 MOSC domain; Region: MOSC; pfam03473 266940011988 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 266940011989 Phosphotransferase enzyme family; Region: APH; pfam01636 266940011990 putative active site [active] 266940011991 putative substrate binding site [chemical binding]; other site 266940011992 ATP binding site [chemical binding]; other site 266940011993 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 266940011994 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 266940011995 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 266940011996 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 266940011997 Protein of unknown function (DUF664); Region: DUF664; pfam04978 266940011998 Protein of unknown function (DUF664); Region: DUF664; pfam04978 266940011999 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683 266940012000 nudix motif; other site 266940012001 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 266940012002 IHF - DNA interface [nucleotide binding]; other site 266940012003 IHF dimer interface [polypeptide binding]; other site 266940012004 Plasmid encoded RepA protein; Region: RepA_C; pfam04796 266940012005 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 266940012006 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 266940012007 putative active site [active] 266940012008 putative metal binding site [ion binding]; other site 266940012009 Transcription factor WhiB; Region: Whib; pfam02467 266940012010 AAA ATPase domain; Region: AAA_16; pfam13191 266940012011 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266940012012 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266940012013 DNA binding residues [nucleotide binding] 266940012014 dimerization interface [polypeptide binding]; other site 266940012015 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266940012016 AAA ATPase domain; Region: AAA_16; pfam13191 266940012017 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266940012018 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266940012019 DNA binding residues [nucleotide binding] 266940012020 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 266940012021 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 266940012022 Walker A/P-loop; other site 266940012023 ATP binding site [chemical binding]; other site 266940012024 Q-loop/lid; other site 266940012025 ABC transporter signature motif; other site 266940012026 Walker B; other site 266940012027 D-loop; other site 266940012028 H-loop/switch region; other site 266940012029 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 266940012030 intracellular protease, PfpI family; Region: PfpI; TIGR01382 266940012031 proposed catalytic triad [active] 266940012032 conserved cys residue [active] 266940012033 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266940012034 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266940012035 active site 266940012036 catalytic tetrad [active] 266940012037 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 266940012038 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 266940012039 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266940012040 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 266940012041 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 266940012042 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 266940012043 DNA binding residues [nucleotide binding] 266940012044 putative dimer interface [polypeptide binding]; other site 266940012045 AAA ATPase domain; Region: AAA_16; pfam13191 266940012046 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266940012047 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266940012048 DNA binding residues [nucleotide binding] 266940012049 dimerization interface [polypeptide binding]; other site 266940012050 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 266940012051 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266940012052 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266940012053 DNA binding residues [nucleotide binding] 266940012054 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 266940012055 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 266940012056 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 266940012057 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 266940012058 pyrimidine utilization protein D; Region: RutD; TIGR03611 266940012059 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940012060 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 266940012061 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 266940012062 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266940012063 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266940012064 active site 266940012065 catalytic tetrad [active] 266940012066 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 266940012067 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266940012068 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266940012069 ligand binding site [chemical binding]; other site 266940012070 flexible hinge region; other site 266940012071 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266940012072 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266940012073 ATP binding site [chemical binding]; other site 266940012074 G-X-G motif; other site 266940012075 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266940012076 Response regulator receiver domain; Region: Response_reg; pfam00072 266940012077 active site 266940012078 phosphorylation site [posttranslational modification] 266940012079 intermolecular recognition site; other site 266940012080 dimerization interface [polypeptide binding]; other site 266940012081 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 266940012082 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266940012083 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266940012084 Cupin domain; Region: Cupin_2; pfam07883 266940012085 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828 266940012086 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266940012087 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266940012088 AAA ATPase domain; Region: AAA_16; pfam13191 266940012089 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266940012090 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266940012091 DNA binding residues [nucleotide binding] 266940012092 dimerization interface [polypeptide binding]; other site 266940012093 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 266940012094 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 266940012095 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266940012096 NmrA-like family; Region: NmrA; pfam05368 266940012097 NAD(P) binding site [chemical binding]; other site 266940012098 active site 266940012099 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 266940012100 SnoaL-like domain; Region: SnoaL_3; pfam13474 266940012101 SnoaL-like domain; Region: SnoaL_2; pfam12680 266940012102 AAA ATPase domain; Region: AAA_16; pfam13191 266940012103 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266940012104 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266940012105 DNA binding residues [nucleotide binding] 266940012106 dimerization interface [polypeptide binding]; other site 266940012107 RNA polymerase sigma factor, SigZ family; Region: SigZ; TIGR02959 266940012108 putative transposase OrfB; Reviewed; Region: PHA02517 266940012109 HTH-like domain; Region: HTH_21; pfam13276 266940012110 Integrase core domain; Region: rve; pfam00665 266940012111 Integrase core domain; Region: rve_3; cl15866 266940012112 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266940012113 Transposase; Region: HTH_Tnp_1; pfam01527 266940012114 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 266940012115 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 266940012116 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266940012117 DNA binding residues [nucleotide binding] 266940012118 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 266940012119 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 266940012120 putative acetyltransferase; Provisional; Region: PRK03624 266940012121 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266940012122 Coenzyme A binding pocket [chemical binding]; other site 266940012123 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 266940012124 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266940012125 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266940012126 DNA binding residues [nucleotide binding] 266940012127 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 266940012128 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266940012129 dimer interface [polypeptide binding]; other site 266940012130 ligand binding site [chemical binding]; other site 266940012131 Nuclease-related domain; Region: NERD; pfam08378 266940012132 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cd00296 266940012133 SIR2-like domain; Region: SIR2_2; pfam13289 266940012134 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266940012135 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 266940012136 Walker A motif; other site 266940012137 ATP binding site [chemical binding]; other site 266940012138 Walker B motif; other site 266940012139 arginine finger; other site 266940012140 RDD family; Region: RDD; pfam06271 266940012141 Lsr2; Region: Lsr2; pfam11774 266940012142 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 266940012143 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 266940012144 LrgB-like family; Region: LrgB; pfam04172 266940012145 LrgA family; Region: LrgA; pfam03788 266940012146 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 266940012147 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 266940012148 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266940012149 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940012150 dimer interface [polypeptide binding]; other site 266940012151 conserved gate region; other site 266940012152 putative PBP binding loops; other site 266940012153 ABC-ATPase subunit interface; other site 266940012154 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 266940012155 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266940012156 putative PBP binding loops; other site 266940012157 dimer interface [polypeptide binding]; other site 266940012158 ABC-ATPase subunit interface; other site 266940012159 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266940012160 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 266940012161 malate synthase A; Region: malate_syn_A; TIGR01344 266940012162 active site 266940012163 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 266940012164 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 266940012165 active site pocket [active] 266940012166 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266940012167 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266940012168 Bacterial transcriptional regulator; Region: IclR; pfam01614 266940012169 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 266940012170 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH10; cd08263 266940012171 putative NAD(P) binding site [chemical binding]; other site 266940012172 catalytic Zn binding site [ion binding]; other site 266940012173 structural Zn binding site [ion binding]; other site 266940012174 Lsr2; Region: Lsr2; pfam11774 266940012175 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 266940012176 Catalytic domain of Protein Kinases; Region: PKc; cd00180 266940012177 active site 266940012178 ATP binding site [chemical binding]; other site 266940012179 substrate binding site [chemical binding]; other site 266940012180 activation loop (A-loop); other site 266940012181 Nuclease-related domain; Region: NERD; pfam08378 266940012182 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 266940012183 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 266940012184 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266940012185 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266940012186 active site 266940012187 phosphorylation site [posttranslational modification] 266940012188 intermolecular recognition site; other site 266940012189 dimerization interface [polypeptide binding]; other site 266940012190 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266940012191 DNA binding residues [nucleotide binding] 266940012192 dimerization interface [polypeptide binding]; other site 266940012193 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 266940012194 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266940012195 ATP binding site [chemical binding]; other site 266940012196 Mg2+ binding site [ion binding]; other site 266940012197 G-X-G motif; other site 266940012198 Predicted membrane protein [Function unknown]; Region: COG1971 266940012199 Domain of unknown function DUF; Region: DUF204; pfam02659 266940012200 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 266940012201 This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases; Region: CHASE; smart01079 266940012202 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266940012203 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266940012204 ATP binding site [chemical binding]; other site 266940012205 Mg2+ binding site [ion binding]; other site 266940012206 G-X-G motif; other site 266940012207 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 266940012208 metal binding site 2 [ion binding]; metal-binding site 266940012209 putative DNA binding helix; other site 266940012210 metal binding site 1 [ion binding]; metal-binding site 266940012211 dimer interface [polypeptide binding]; other site 266940012212 structural Zn2+ binding site [ion binding]; other site 266940012213 Predicted integral membrane protein [Function unknown]; Region: COG0392 266940012214 Uncharacterized conserved protein [Function unknown]; Region: COG2898 266940012215 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 266940012216 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 266940012217 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 266940012218 Catalytic site [active] 266940012219 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 266940012220 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 266940012221 putative active site [active] 266940012222 putative metal binding site [ion binding]; other site 266940012223 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 266940012224 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266940012225 dimerization interface [polypeptide binding]; other site 266940012226 putative DNA binding site [nucleotide binding]; other site 266940012227 putative Zn2+ binding site [ion binding]; other site 266940012228 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 266940012229 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 266940012230 CopC domain; Region: CopC; pfam04234 266940012231 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 266940012232 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 266940012233 active site 266940012234 dimer interface [polypeptide binding]; other site 266940012235 Alkaline phosphatase homologues; Region: alkPPc; smart00098 266940012236 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266940012237 dimerization interface [polypeptide binding]; other site 266940012238 putative DNA binding site [nucleotide binding]; other site 266940012239 putative Zn2+ binding site [ion binding]; other site 266940012240 Cation efflux family; Region: Cation_efflux; cl00316 266940012241 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 266940012242 NlpC/P60 family; Region: NLPC_P60; pfam00877 266940012243 Uncharacterized conserved protein [Function unknown]; Region: COG2898 266940012244 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 266940012245 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 266940012246 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 266940012247 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 266940012248 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 266940012249 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 266940012250 ResB-like family; Region: ResB; pfam05140 266940012251 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 266940012252 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 266940012253 putative active site [active] 266940012254 catalytic triad [active] 266940012255 putative dimer interface [polypeptide binding]; other site 266940012256 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 266940012257 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 266940012258 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 266940012259 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 266940012260 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 266940012261 catalytic residues [active] 266940012262 Copper resistance protein D; Region: CopD; pfam05425 266940012263 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 266940012264 CopC domain; Region: CopC; pfam04234 266940012265 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 266940012266 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266940012267 dimerization interface [polypeptide binding]; other site 266940012268 putative DNA binding site [nucleotide binding]; other site 266940012269 putative Zn2+ binding site [ion binding]; other site 266940012270 Thioredoxin; Region: Thioredoxin_4; pfam13462 266940012271 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 266940012272 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 266940012273 putative active site [active] 266940012274 redox center [active] 266940012275 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 266940012276 Domain of unknown function (DUF305); Region: DUF305; pfam03713 266940012277 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 266940012278 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266940012279 dimerization interface [polypeptide binding]; other site 266940012280 putative DNA binding site [nucleotide binding]; other site 266940012281 putative Zn2+ binding site [ion binding]; other site 266940012282 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 266940012283 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 266940012284 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 266940012285 Domain of unknown function (DUF305); Region: DUF305; pfam03713 266940012286 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 266940012287 putative homodimer interface [polypeptide binding]; other site 266940012288 putative homotetramer interface [polypeptide binding]; other site 266940012289 putative allosteric switch controlling residues; other site 266940012290 putative metal binding site [ion binding]; other site 266940012291 putative homodimer-homodimer interface [polypeptide binding]; other site 266940012292 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266940012293 metal-binding site [ion binding] 266940012294 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266940012295 metal-binding site [ion binding] 266940012296 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 266940012297 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266940012298 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 266940012299 Ycf48-like protein; Provisional; Region: PRK13684 266940012300 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 266940012301 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 266940012302 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 266940012303 generic binding surface II; other site 266940012304 generic binding surface I; other site 266940012305 hypothetical protein; Provisional; Region: PRK06185 266940012306 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 266940012307 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 266940012308 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 266940012309 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 266940012310 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 266940012311 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 266940012312 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 266940012313 putative CoA binding site [chemical binding]; other site 266940012314 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 266940012315 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266940012316 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266940012317 catalytic residue [active] 266940012318 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 266940012319 NlpC/P60 family; Region: NLPC_P60; pfam00877 266940012320 AAA-like domain; Region: AAA_10; pfam12846 266940012321 Domain of unknown function DUF87; Region: DUF87; pfam01935 266940012322 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 266940012323 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 266940012324 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266940012325 P-loop; other site 266940012326 Magnesium ion binding site [ion binding]; other site 266940012327 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266940012328 Magnesium ion binding site [ion binding]; other site 266940012329 ribonuclease III; Reviewed; Region: PRK12372 266940012330 Helix-turn-helix domain; Region: HTH_17; cl17695 266940012331 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 266940012332 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 266940012333 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 266940012334 ATP binding site [chemical binding]; other site 266940012335 Walker A motif; other site 266940012336 hexamer interface [polypeptide binding]; other site 266940012337 Walker B motif; other site 266940012338 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 266940012339 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 266940012340 TadE-like protein; Region: TadE; pfam07811 266940012341 Bacterial transcriptional activator domain; Region: BTAD; smart01043 266940012342 Helix-turn-helix domain; Region: HTH_36; pfam13730 266940012343 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 266940012344 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 266940012345 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 266940012346 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 266940012347 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 266940012348 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 266940012349 putative active site [active] 266940012350 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 266940012351 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266940012352 Walker A/P-loop; other site 266940012353 ATP binding site [chemical binding]; other site 266940012354 Q-loop/lid; other site 266940012355 ABC transporter signature motif; other site 266940012356 Walker B; other site 266940012357 D-loop; other site 266940012358 H-loop/switch region; other site 266940012359 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 266940012360 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 266940012361 active site 266940012362 catalytic site [active] 266940012363 substrate binding site [chemical binding]; other site 266940012364 Transcription factor WhiB; Region: Whib; pfam02467 266940012365 LIM is a small protein-protein interaction domain, containing two zinc fingers; Region: LIM; cl02475 266940012366 Zn binding site [ion binding]; other site 266940012367 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 266940012368 active site 266940012369 ATP binding site [chemical binding]; other site 266940012370 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 266940012371 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 266940012372 SlyX; Region: SlyX; cl01090 266940012373 Protein of unknown function (DUF664); Region: DUF664; pfam04978 266940012374 DinB superfamily; Region: DinB_2; pfam12867