-- dump date 20140619_120715 -- class Genbank::misc_feature -- table misc_feature_note -- id note 452652000001 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 452652000002 ATP binding site [chemical binding]; other site 452652000003 putative Mg++ binding site [ion binding]; other site 452652000004 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 452652000005 Helicase associated domain; Region: HA; pfam03457 452652000006 Helicase associated domain; Region: HA; pfam03457 452652000007 Helicase associated domain; Region: HA; pfam03457 452652000008 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 452652000009 active site 452652000010 AAA domain; Region: AAA_23; pfam13476 452652000011 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 452652000012 G1 box; other site 452652000013 GTP/Mg2+ binding site [chemical binding]; other site 452652000014 G2 box; other site 452652000015 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 452652000016 Family description; Region: UvrD_C_2; pfam13538 452652000017 Nucleotidyltransferase domain; Region: NTP_transf_2; pfam01909 452652000018 metal binding triad [ion binding]; metal-binding site 452652000019 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 452652000020 ATP binding site [chemical binding]; other site 452652000021 putative Mg++ binding site [ion binding]; other site 452652000022 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 452652000023 nucleotide binding region [chemical binding]; other site 452652000024 ATP-binding site [chemical binding]; other site 452652000025 Helicase associated domain; Region: HA; pfam03457 452652000026 Helicase associated domain; Region: HA; pfam03457 452652000027 Helicase associated domain; Region: HA; pfam03457 452652000028 Helicase associated domain; Region: HA; pfam03457 452652000029 Helicase associated domain; Region: HA; pfam03457 452652000030 Helicase associated domain; Region: HA; pfam03457 452652000031 Helicase associated domain; Region: HA; pfam03457 452652000032 Integrase core domain; Region: rve; pfam00665 452652000033 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 452652000034 Archaeal ATPase; Region: Arch_ATPase; pfam01637 452652000035 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 452652000036 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 452652000037 ATP binding site [chemical binding]; other site 452652000038 putative Mg++ binding site [ion binding]; other site 452652000039 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 452652000040 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 452652000041 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 452652000042 substrate binding pocket [chemical binding]; other site 452652000043 substrate-Mg2+ binding site; other site 452652000044 aspartate-rich region 1; other site 452652000045 aspartate-rich region 2; other site 452652000046 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 452652000047 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 452652000048 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 452652000049 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 452652000050 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 452652000051 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 452652000052 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 452652000053 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 452652000054 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 452652000055 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 452652000056 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 452652000057 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 452652000058 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 452652000059 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 452652000060 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 452652000061 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 452652000062 potential frameshift: common BLAST hit: gi|169628632|ref|YP_001702281.1| amino acid permease 452652000063 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 452652000064 roof hairpin; other site 452652000065 oligomerisation interface [polypeptide binding]; other site 452652000066 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 452652000067 active site 452652000068 legume lectins; Region: lectin_L-type; cl14058 452652000069 homotetramer interaction site [polypeptide binding]; other site 452652000070 carbohydrate binding site [chemical binding]; other site 452652000071 metal binding site [ion binding]; metal-binding site 452652000072 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 452652000073 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 452652000074 LytB protein; Region: LYTB; cl00507 452652000075 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 452652000076 Cytochrome P450; Region: p450; cl12078 452652000077 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652000078 S-adenosylmethionine binding site [chemical binding]; other site 452652000079 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 452652000080 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 452652000081 TAP-like protein; Region: Abhydrolase_4; pfam08386 452652000082 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 452652000083 dimerization interface [polypeptide binding]; other site 452652000084 Transcriptional regulator [Transcription]; Region: LysR; COG0583 452652000085 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 452652000086 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 452652000087 Leucine carboxyl methyltransferase; Region: LCM; cl01306 452652000088 GH3 auxin-responsive promoter; Region: GH3; pfam03321 452652000089 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 452652000090 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 452652000091 active site 452652000092 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652000093 salt bridge; other site 452652000094 non-specific DNA binding site [nucleotide binding]; other site 452652000095 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 452652000096 sequence-specific DNA binding site [nucleotide binding]; other site 452652000097 Major Facilitator Superfamily; Region: MFS_1; pfam07690 452652000098 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652000099 putative substrate translocation pore; other site 452652000100 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652000101 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 452652000102 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 452652000103 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 452652000104 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 452652000105 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 452652000106 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 452652000107 Family description; Region: VCBS; pfam13517 452652000108 Family description; Region: VCBS; pfam13517 452652000109 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 452652000110 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 452652000111 active site 452652000112 homodimer interface [polypeptide binding]; other site 452652000113 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 452652000114 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 452652000115 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 452652000116 active site 452652000117 substrate binding site [chemical binding]; other site 452652000118 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 452652000119 FAD binding domain; Region: FAD_binding_4; pfam01565 452652000120 Berberine and berberine like; Region: BBE; pfam08031 452652000121 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 452652000122 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652000123 putative substrate translocation pore; other site 452652000124 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652000125 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452652000126 DNA binding residues [nucleotide binding] 452652000127 short chain dehydrogenase; Provisional; Region: PRK06523 452652000128 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652000129 NAD(P) binding site [chemical binding]; other site 452652000130 active site 452652000131 Major Facilitator Superfamily; Region: MFS_1; pfam07690 452652000132 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652000133 putative substrate translocation pore; other site 452652000134 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652000135 ParB-like nuclease domain; Region: ParB; smart00470 452652000136 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 452652000137 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 452652000138 active site 452652000139 tetramer interface; other site 452652000140 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 452652000141 MarR family; Region: MarR_2; pfam12802 452652000142 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 452652000143 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 452652000144 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 452652000145 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 452652000146 trehalose synthase; Region: treS_nterm; TIGR02456 452652000147 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 452652000148 active site 452652000149 catalytic site [active] 452652000150 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 452652000151 conserved cys residue [active] 452652000152 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 452652000153 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 452652000154 PYR/PP interface [polypeptide binding]; other site 452652000155 dimer interface [polypeptide binding]; other site 452652000156 TPP binding site [chemical binding]; other site 452652000157 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 452652000158 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 452652000159 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 452652000160 TPP-binding site [chemical binding]; other site 452652000161 dimer interface [polypeptide binding]; other site 452652000162 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 452652000163 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 452652000164 intracellular protease, PfpI family; Region: PfpI; TIGR01382 452652000165 conserved cys residue [active] 452652000166 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 452652000167 dimerization interface [polypeptide binding]; other site 452652000168 putative active cleft [active] 452652000169 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme; Region: E_set_GDE_N; cd11234 452652000170 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 452652000171 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 452652000172 active site 452652000173 catalytic site [active] 452652000174 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 452652000175 anti sigma factor interaction site; other site 452652000176 regulatory phosphorylation site [posttranslational modification]; other site 452652000177 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 452652000178 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 452652000179 active site 452652000180 Substrate binding site; other site 452652000181 Mg++ binding site; other site 452652000182 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 452652000183 putative trimer interface [polypeptide binding]; other site 452652000184 putative CoA binding site [chemical binding]; other site 452652000185 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 452652000186 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 452652000187 active site 452652000188 substrate binding site [chemical binding]; other site 452652000189 metal binding site [ion binding]; metal-binding site 452652000190 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 452652000191 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 452652000192 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 452652000193 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652000194 putative substrate translocation pore; other site 452652000195 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652000196 DDE superfamily endonuclease; Region: DDE_5; cl17874 452652000197 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 452652000198 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652000199 NAD(P) binding site [chemical binding]; other site 452652000200 active site 452652000201 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652000202 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652000203 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 452652000204 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 452652000205 Streptomyces killer toxin-like; Region: Sklp_toxin; pfam09076 452652000206 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 452652000207 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 452652000208 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 452652000209 putative catalytic site [active] 452652000210 putative metal binding site [ion binding]; other site 452652000211 putative phosphate binding site [ion binding]; other site 452652000212 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 452652000213 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652000214 active site 452652000215 phosphorylation site [posttranslational modification] 452652000216 intermolecular recognition site; other site 452652000217 dimerization interface [polypeptide binding]; other site 452652000218 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 452652000219 DNA binding site [nucleotide binding] 452652000220 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452652000221 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452652000222 dimer interface [polypeptide binding]; other site 452652000223 phosphorylation site [posttranslational modification] 452652000224 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652000225 ATP binding site [chemical binding]; other site 452652000226 Mg2+ binding site [ion binding]; other site 452652000227 G-X-G motif; other site 452652000228 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 452652000229 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 452652000230 calcium binding site 2 [ion binding]; other site 452652000231 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 452652000232 active site 452652000233 catalytic triad [active] 452652000234 calcium binding site 1 [ion binding]; other site 452652000235 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 452652000236 SpoOM protein; Region: Spo0M; pfam07070 452652000237 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 452652000238 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652000239 S-adenosylmethionine binding site [chemical binding]; other site 452652000240 Predicted membrane protein [Function unknown]; Region: COG3463 452652000241 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 452652000242 Predicted transcriptional regulators [Transcription]; Region: COG1725 452652000243 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 452652000244 DNA-binding site [nucleotide binding]; DNA binding site 452652000245 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 452652000246 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 452652000247 Walker A/P-loop; other site 452652000248 ATP binding site [chemical binding]; other site 452652000249 Q-loop/lid; other site 452652000250 ABC transporter signature motif; other site 452652000251 Walker B; other site 452652000252 D-loop; other site 452652000253 H-loop/switch region; other site 452652000254 TAP-like protein; Region: Abhydrolase_4; pfam08386 452652000255 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 452652000256 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 452652000257 active site 452652000258 metal binding site [ion binding]; metal-binding site 452652000259 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 452652000260 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 452652000261 EF-hand domain pair; Region: EF_hand_5; pfam13499 452652000262 Ca2+ binding site [ion binding]; other site 452652000263 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 452652000264 EF-hand domain pair; Region: EF_hand_5; pfam13499 452652000265 Ca2+ binding site [ion binding]; other site 452652000266 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 452652000267 EF-hand domain pair; Region: EF_hand_5; pfam13499 452652000268 Ca2+ binding site [ion binding]; other site 452652000269 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 452652000270 active site 452652000271 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 452652000272 nudix motif; other site 452652000273 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 452652000274 pantoate--beta-alanine ligase; Region: panC; TIGR00018 452652000275 active site 452652000276 nucleotide binding site [chemical binding]; other site 452652000277 HIGH motif; other site 452652000278 KMSKS motif; other site 452652000279 TIR domain; Region: TIR_2; pfam13676 452652000280 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 452652000281 active site 452652000282 metal binding site [ion binding]; metal-binding site 452652000283 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 452652000284 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452652000285 NACHT domain; Region: NACHT; pfam05729 452652000286 Walker A motif; other site 452652000287 ATP binding site [chemical binding]; other site 452652000288 Walker B motif; other site 452652000289 arginine finger; other site 452652000290 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 452652000291 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 452652000292 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 452652000293 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 452652000294 FOG: WD40 repeat [General function prediction only]; Region: COG2319 452652000295 structural tetrad; other site 452652000296 FOG: WD40 repeat [General function prediction only]; Region: COG2319 452652000297 WD domain, G-beta repeat; Region: WD40; pfam00400 452652000298 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 452652000299 structural tetrad; other site 452652000300 PQQ-like domain; Region: PQQ_2; pfam13360 452652000301 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 452652000302 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 452652000303 transmembrane helices; other site 452652000304 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 452652000305 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 452652000306 active site 452652000307 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 452652000308 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 452652000309 NAD binding site [chemical binding]; other site 452652000310 catalytic Zn binding site [ion binding]; other site 452652000311 substrate binding site [chemical binding]; other site 452652000312 structural Zn binding site [ion binding]; other site 452652000313 myosin-cross-reactive antigen; Provisional; Region: PRK13977 452652000314 multicopper oxidase; Provisional; Region: PRK10965 452652000315 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 452652000316 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 452652000317 Cellulose binding domain; Region: CBM_3; pfam00942 452652000318 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 452652000319 active site 452652000320 catalytic residues [active] 452652000321 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 452652000322 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 452652000323 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 452652000324 active site 452652000325 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 452652000326 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652000327 dimer interface [polypeptide binding]; other site 452652000328 conserved gate region; other site 452652000329 putative PBP binding loops; other site 452652000330 ABC-ATPase subunit interface; other site 452652000331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 452652000332 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652000333 putative PBP binding loops; other site 452652000334 ABC-ATPase subunit interface; other site 452652000335 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 452652000336 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 452652000337 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 452652000338 DNA-binding site [nucleotide binding]; DNA binding site 452652000339 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 452652000340 UTRA domain; Region: UTRA; pfam07702 452652000341 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652000342 salt bridge; other site 452652000343 non-specific DNA binding site [nucleotide binding]; other site 452652000344 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 452652000345 sequence-specific DNA binding site [nucleotide binding]; other site 452652000346 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 452652000347 Transcriptional regulator [Transcription]; Region: LysR; COG0583 452652000348 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 452652000349 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 452652000350 dimerization interface [polypeptide binding]; other site 452652000351 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652000352 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652000353 Major Facilitator Superfamily; Region: MFS_1; pfam07690 452652000354 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 452652000355 catalytic triad [active] 452652000356 conserved cis-peptide bond; other site 452652000357 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 452652000358 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 452652000359 conserved cys residue [active] 452652000360 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452652000361 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452652000362 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 452652000363 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 452652000364 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 452652000365 dimerization interface [polypeptide binding]; other site 452652000366 Bulb-type mannose-specific lectin; Region: B_lectin; smart00108 452652000367 mannose binding site [chemical binding]; other site 452652000368 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 452652000369 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 452652000370 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 452652000371 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 452652000372 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 452652000373 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 452652000374 putative trimer interface [polypeptide binding]; other site 452652000375 putative CoA binding site [chemical binding]; other site 452652000376 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 452652000377 putative ADP-ribose binding site [chemical binding]; other site 452652000378 putative active site [active] 452652000379 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 452652000380 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 452652000381 active site 452652000382 Penicillinase repressor; Region: Pencillinase_R; cl17580 452652000383 Peptidase family M48; Region: Peptidase_M48; cl12018 452652000384 Transcriptional regulator [Transcription]; Region: LytR; COG1316 452652000385 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 452652000386 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 452652000387 N-acetyl-D-glucosamine binding site [chemical binding]; other site 452652000388 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 452652000389 peptide chain release factor 1, archaeal and eukaryotic forms; Region: aRF1/eRF1; TIGR03676 452652000390 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 452652000391 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 452652000392 Peptidase M35 family; Region: M35_like; cl03449 452652000393 active site 452652000394 Zn binding site [ion binding]; other site 452652000395 Peptidase M35 family; Region: M35_like; cl03449 452652000396 active site 452652000397 Zn binding site [ion binding]; other site 452652000398 Epoxide hydrolase N terminus; Region: EHN; pfam06441 452652000399 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 452652000400 MarR family; Region: MarR_2; cl17246 452652000401 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 452652000402 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452652000403 Coenzyme A binding pocket [chemical binding]; other site 452652000404 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 452652000405 ADP-ribose binding site [chemical binding]; other site 452652000406 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 452652000407 ligand binding site [chemical binding]; other site 452652000408 active site 452652000409 NAD:arginine ADP-ribosyltransferase; Region: ART; pfam01129 452652000410 hypothetical protein; Provisional; Region: PRK08317 452652000411 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 452652000412 Beta-lactamase; Region: Beta-lactamase; pfam00144 452652000413 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 452652000414 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 452652000415 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 452652000416 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652000417 NAD(P) binding site [chemical binding]; other site 452652000418 active site 452652000419 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 452652000420 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 452652000421 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 452652000422 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 452652000423 homotrimer interaction site [polypeptide binding]; other site 452652000424 putative active site [active] 452652000425 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 452652000426 Cytochrome P450; Region: p450; cl12078 452652000427 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 452652000428 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 452652000429 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 452652000430 putative dimer interface [polypeptide binding]; other site 452652000431 ligand binding site [chemical binding]; other site 452652000432 Zn binding site [ion binding]; other site 452652000433 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 452652000434 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 452652000435 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 452652000436 Transcriptional regulators [Transcription]; Region: PurR; COG1609 452652000437 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 452652000438 DNA binding site [nucleotide binding] 452652000439 domain linker motif; other site 452652000440 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 452652000441 putative dimerization interface [polypeptide binding]; other site 452652000442 putative ligand binding site [chemical binding]; other site 452652000443 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 452652000444 sugar binding site [chemical binding]; other site 452652000445 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 452652000446 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 452652000447 sugar binding site [chemical binding]; other site 452652000448 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 452652000449 sugar binding site [chemical binding]; other site 452652000450 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 452652000451 active site 452652000452 catalytic residues [active] 452652000453 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 452652000454 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 452652000455 sugar binding site [chemical binding]; other site 452652000456 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 452652000457 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 452652000458 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652000459 dimer interface [polypeptide binding]; other site 452652000460 putative PBP binding loops; other site 452652000461 ABC-ATPase subunit interface; other site 452652000462 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 452652000463 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652000464 dimer interface [polypeptide binding]; other site 452652000465 conserved gate region; other site 452652000466 ABC-ATPase subunit interface; other site 452652000467 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 452652000468 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 452652000469 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 452652000470 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 452652000471 substrate binding site [chemical binding]; other site 452652000472 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 452652000473 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 452652000474 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 452652000475 putative molybdopterin cofactor binding site [chemical binding]; other site 452652000476 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 452652000477 molybdopterin cofactor binding site; other site 452652000478 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 452652000479 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 452652000480 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 452652000481 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 452652000482 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 452652000483 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 452652000484 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652000485 putative substrate translocation pore; other site 452652000486 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; cl17321 452652000487 Transcriptional regulators [Transcription]; Region: PurR; COG1609 452652000488 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 452652000489 DNA binding site [nucleotide binding] 452652000490 domain linker motif; other site 452652000491 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 452652000492 putative dimerization interface [polypeptide binding]; other site 452652000493 putative ligand binding site [chemical binding]; other site 452652000494 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 452652000495 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 452652000496 FMN binding site [chemical binding]; other site 452652000497 active site 452652000498 substrate binding site [chemical binding]; other site 452652000499 catalytic residue [active] 452652000500 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 452652000501 substrate-cofactor binding pocket; other site 452652000502 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 452652000503 Acylphosphatase; Region: Acylphosphatase; cl00551 452652000504 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 452652000505 active site 452652000506 catalytic motif [active] 452652000507 Zn binding site [ion binding]; other site 452652000508 Protein of unknown function (DUF664); Region: DUF664; pfam04978 452652000509 DinB superfamily; Region: DinB_2; pfam12867 452652000510 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652000511 bacteriocin maturation radical SAM protein 1; Region: rSAM_ocin_1; TIGR03975 452652000512 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 452652000513 FeS/SAM binding site; other site 452652000514 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 452652000515 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 452652000516 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 452652000517 Amino acid permease; Region: AA_permease_2; pfam13520 452652000518 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 452652000519 Amino acid permease; Region: AA_permease_2; pfam13520 452652000520 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 452652000521 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 452652000522 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 452652000523 nudix motif; other site 452652000524 hypothetical protein; Provisional; Region: PRK06762 452652000525 AAA domain; Region: AAA_33; pfam13671 452652000526 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 452652000527 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 452652000528 2-dehydropantoate 2-reductase; Provisional; Region: PRK08229 452652000529 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 452652000530 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 452652000531 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452652000532 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 452652000533 Coenzyme A binding pocket [chemical binding]; other site 452652000534 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 452652000535 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 452652000536 motif II; other site 452652000537 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 452652000538 putative active site [active] 452652000539 putative metal-binding site [ion binding]; other site 452652000540 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 452652000541 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652000542 putative substrate translocation pore; other site 452652000543 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652000544 Major Facilitator Superfamily; Region: MFS_1; pfam07690 452652000545 MarR family; Region: MarR; pfam01047 452652000546 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 452652000547 putative active site; other site 452652000548 putative metal binding residues [ion binding]; other site 452652000549 signature motif; other site 452652000550 putative triphosphate binding site [ion binding]; other site 452652000551 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 452652000552 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 452652000553 ligand binding site [chemical binding]; other site 452652000554 flexible hinge region; other site 452652000555 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 452652000556 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 452652000557 nucleophile elbow; other site 452652000558 Phosphate acyltransferases; Region: PlsC; smart00563 452652000559 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 452652000560 cell envelope-related function transcriptional attenuator common domain; Region: lytR_cpsA_psr; TIGR00350 452652000561 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 452652000562 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 452652000563 active site 452652000564 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 452652000565 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 452652000566 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 452652000567 Beta-lactamase; Region: Beta-lactamase; pfam00144 452652000568 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 452652000569 hypothetical protein; Provisional; Region: PRK07236 452652000570 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 452652000571 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 452652000572 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 452652000573 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 452652000574 aromatic chitin/cellulose binding site residues [chemical binding]; other site 452652000575 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 452652000576 active site 452652000577 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 452652000578 aromatic chitin/cellulose binding site residues [chemical binding]; other site 452652000579 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 452652000580 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 452652000581 aromatic chitin/cellulose binding site residues [chemical binding]; other site 452652000582 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 452652000583 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 452652000584 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 452652000585 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 452652000586 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 452652000587 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 452652000588 MarR family; Region: MarR; pfam01047 452652000589 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 452652000590 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652000591 putative substrate translocation pore; other site 452652000592 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 452652000593 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 452652000594 Cytochrome P450; Region: p450; cl12078 452652000595 Transcriptional regulators [Transcription]; Region: PurR; COG1609 452652000596 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 452652000597 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 452652000598 conserved cys residue [active] 452652000599 RNA polymerase factor sigma-70; Validated; Region: PRK08241 452652000600 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652000601 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452652000602 DNA binding residues [nucleotide binding] 452652000603 SnoaL-like domain; Region: SnoaL_2; pfam12680 452652000604 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 452652000605 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 452652000606 Walker A/P-loop; other site 452652000607 ATP binding site [chemical binding]; other site 452652000608 Q-loop/lid; other site 452652000609 ABC transporter signature motif; other site 452652000610 Walker B; other site 452652000611 D-loop; other site 452652000612 H-loop/switch region; other site 452652000613 RNA polymerase factor sigma-70; Validated; Region: PRK08241 452652000614 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652000615 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452652000616 DNA binding residues [nucleotide binding] 452652000617 SnoaL-like domain; Region: SnoaL_2; pfam12680 452652000618 Methyltransferase domain; Region: Methyltransf_31; pfam13847 452652000619 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652000620 S-adenosylmethionine binding site [chemical binding]; other site 452652000621 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 452652000622 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652000623 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 452652000624 NAD(P) binding site [chemical binding]; other site 452652000625 active site 452652000626 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652000627 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652000628 Iron permease FTR1 family; Region: FTR1; pfam03239 452652000629 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 452652000630 Imelysin; Region: Peptidase_M75; pfam09375 452652000631 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 452652000632 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 452652000633 active site 452652000634 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 452652000635 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652000636 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452652000637 Tetratricopeptide repeat; Region: TPR_16; pfam13432 452652000638 binding surface 452652000639 TPR motif; other site 452652000640 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 452652000641 GAF domain; Region: GAF_2; pfam13185 452652000642 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 452652000643 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 452652000644 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652000645 Mg2+ binding site [ion binding]; other site 452652000646 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 452652000647 putative substrate binding pocket [chemical binding]; other site 452652000648 trimer interface [polypeptide binding]; other site 452652000649 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652000650 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652000651 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 452652000652 active site 452652000653 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 452652000654 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 452652000655 Walker A/P-loop; other site 452652000656 ATP binding site [chemical binding]; other site 452652000657 Q-loop/lid; other site 452652000658 ABC transporter signature motif; other site 452652000659 Walker B; other site 452652000660 D-loop; other site 452652000661 H-loop/switch region; other site 452652000662 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 452652000663 catalytic site [active] 452652000664 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 452652000665 Protein of unknown function (DUF4243); Region: DUF4243; pfam14027 452652000666 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 452652000667 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 452652000668 putative active site [active] 452652000669 putative metal binding site [ion binding]; other site 452652000670 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 452652000671 N-acetyl-D-glucosamine binding site [chemical binding]; other site 452652000672 catalytic residue [active] 452652000673 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 452652000674 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 452652000675 active site 452652000676 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 452652000677 NADH(P)-binding; Region: NAD_binding_10; pfam13460 452652000678 NAD binding site [chemical binding]; other site 452652000679 substrate binding site [chemical binding]; other site 452652000680 putative active site [active] 452652000681 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652000682 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652000683 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 452652000684 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 452652000685 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 452652000686 FAD binding domain; Region: FAD_binding_4; pfam01565 452652000687 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 452652000688 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 452652000689 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 452652000690 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 452652000691 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 452652000692 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 452652000693 CoenzymeA binding site [chemical binding]; other site 452652000694 subunit interaction site [polypeptide binding]; other site 452652000695 PHB binding site; other site 452652000696 FOG: CBS domain [General function prediction only]; Region: COG0517 452652000697 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 452652000698 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 452652000699 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 452652000700 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 452652000701 Fe-S cluster binding site [ion binding]; other site 452652000702 DNA binding site [nucleotide binding] 452652000703 active site 452652000704 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 452652000705 Cytochrome P450; Region: p450; cl12078 452652000706 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 452652000707 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652000708 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 452652000709 putative substrate translocation pore; other site 452652000710 Uncharacterized conserved protein [Function unknown]; Region: COG5361 452652000711 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 452652000712 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 452652000713 putative sugar binding sites [chemical binding]; other site 452652000714 Q-X-W motif; other site 452652000715 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 452652000716 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 452652000717 RHS Repeat; Region: RHS_repeat; pfam05593 452652000718 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 452652000719 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 452652000720 protein-splicing catalytic site; other site 452652000721 thioester formation/cholesterol transfer; other site 452652000722 Pretoxin HINT domain; Region: PT-HINT; pfam07591 452652000723 GIY-YIG catalytic domain; Region: GIY-YIG; pfam01541 452652000724 GIY-YIG motif/motif A; other site 452652000725 active site 452652000726 catalytic site [active] 452652000727 metal binding site [ion binding]; metal-binding site 452652000728 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452652000729 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 452652000730 Walker A motif; other site 452652000731 ATP binding site [chemical binding]; other site 452652000732 Walker B motif; other site 452652000733 hypothetical protein; Provisional; Region: PRK01346 452652000734 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 452652000735 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 452652000736 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 452652000737 tetramer interface [polypeptide binding]; other site 452652000738 active site 452652000739 Mg2+/Mn2+ binding site [ion binding]; other site 452652000740 MarR family; Region: MarR_2; pfam12802 452652000741 enterobactin exporter EntS; Provisional; Region: PRK10489 452652000742 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 452652000743 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 452652000744 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 452652000745 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 452652000746 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652000747 NAD(P) binding site [chemical binding]; other site 452652000748 active site 452652000749 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 452652000750 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 452652000751 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 452652000752 active site 452652000753 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 452652000754 active site 452652000755 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652000756 NAD(P) binding site [chemical binding]; other site 452652000757 active site 452652000758 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 452652000759 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 452652000760 classical (c) SDRs; Region: SDR_c; cd05233 452652000761 NAD(P) binding site [chemical binding]; other site 452652000762 active site 452652000763 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652000764 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652000765 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652000766 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 452652000767 Predicted transcriptional regulators [Transcription]; Region: COG1695 452652000768 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 452652000769 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 452652000770 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 452652000771 active site 452652000772 catalytic site [active] 452652000773 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 452652000774 glutamate dehydrogenase; Provisional; Region: PRK09414 452652000775 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 452652000776 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 452652000777 NAD(P) binding site [chemical binding]; other site 452652000778 Chitin binding domain; Region: Chitin_bind_3; pfam03067 452652000779 Cellulose binding domain; Region: CBM_2; cl17741 452652000780 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 452652000781 active site 452652000782 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652000783 Major Facilitator Superfamily; Region: MFS_1; pfam07690 452652000784 putative substrate translocation pore; other site 452652000785 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652000786 tetracycline repressor protein TetR; Provisional; Region: PRK13756 452652000787 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652000788 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 452652000789 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 452652000790 active site 452652000791 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 452652000792 aromatic chitin/cellulose binding site residues [chemical binding]; other site 452652000793 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 452652000794 Protein of unknown function (DUF664); Region: DUF664; pfam04978 452652000795 serine hydroxymethyltransferase; Provisional; Region: PRK13580 452652000796 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 452652000797 dimer interface [polypeptide binding]; other site 452652000798 active site 452652000799 glycine-pyridoxal phosphate binding site [chemical binding]; other site 452652000800 folate binding site [chemical binding]; other site 452652000801 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 452652000802 Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162 452652000803 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 452652000804 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652000805 Major Facilitator Superfamily; Region: MFS_1; pfam07690 452652000806 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652000807 H+ Antiporter protein; Region: 2A0121; TIGR00900 452652000808 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 452652000809 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 452652000810 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 452652000811 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 452652000812 putative active site [active] 452652000813 putative metal binding site [ion binding]; other site 452652000814 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 452652000815 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 452652000816 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 452652000817 active site 452652000818 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452652000819 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 452652000820 putative active site [active] 452652000821 heme pocket [chemical binding]; other site 452652000822 GAF domain; Region: GAF; cl17456 452652000823 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 452652000824 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 452652000825 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 452652000826 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 452652000827 short chain dehydrogenase; Provisional; Region: PRK06057 452652000828 classical (c) SDRs; Region: SDR_c; cd05233 452652000829 NAD(P) binding site [chemical binding]; other site 452652000830 active site 452652000831 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 452652000832 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 452652000833 NAD(P) binding site [chemical binding]; other site 452652000834 catalytic residues [active] 452652000835 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 452652000836 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 452652000837 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 452652000838 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 452652000839 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452652000840 Coenzyme A binding pocket [chemical binding]; other site 452652000841 MgtE intracellular N domain; Region: MgtE_N; pfam03448 452652000842 FOG: CBS domain [General function prediction only]; Region: COG0517 452652000843 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 452652000844 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 452652000845 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 452652000846 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 452652000847 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 452652000848 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 452652000849 Beta-lactamase; Region: Beta-lactamase; pfam00144 452652000850 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 452652000851 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 452652000852 Zn binding site [ion binding]; other site 452652000853 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 452652000854 Catalytic domain of Protein Kinases; Region: PKc; cd00180 452652000855 active site 452652000856 ATP binding site [chemical binding]; other site 452652000857 substrate binding site [chemical binding]; other site 452652000858 activation loop (A-loop); other site 452652000859 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 452652000860 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 452652000861 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 452652000862 phosphopeptide binding site; other site 452652000863 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 452652000864 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 452652000865 phosphopeptide binding site; other site 452652000866 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 452652000867 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 452652000868 Walker A/P-loop; other site 452652000869 ATP binding site [chemical binding]; other site 452652000870 Q-loop/lid; other site 452652000871 ABC transporter signature motif; other site 452652000872 Walker B; other site 452652000873 D-loop; other site 452652000874 H-loop/switch region; other site 452652000875 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 452652000876 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 452652000877 Catalytic domain of Protein Kinases; Region: PKc; cd00180 452652000878 active site 452652000879 ATP binding site [chemical binding]; other site 452652000880 substrate binding site [chemical binding]; other site 452652000881 activation loop (A-loop); other site 452652000882 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 452652000883 HD domain; Region: HD_4; pfam13328 452652000884 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 452652000885 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 452652000886 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 452652000887 putative DNA binding site [nucleotide binding]; other site 452652000888 catalytic residue [active] 452652000889 putative H2TH interface [polypeptide binding]; other site 452652000890 putative catalytic residues [active] 452652000891 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 452652000892 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 452652000893 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 452652000894 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 452652000895 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 452652000896 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 452652000897 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 452652000898 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 452652000899 catalytic site [active] 452652000900 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 452652000901 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 452652000902 Beta-lactamase; Region: Beta-lactamase; pfam00144 452652000903 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 452652000904 Uncharacterized conserved protein [Function unknown]; Region: COG2128 452652000905 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 452652000906 Pirin-related protein [General function prediction only]; Region: COG1741 452652000907 Pirin; Region: Pirin; pfam02678 452652000908 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 452652000909 DDE superfamily endonuclease; Region: DDE_5; pfam13546 452652000910 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 452652000911 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 452652000912 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 452652000913 DDE superfamily endonuclease; Region: DDE_5; pfam13546 452652000914 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 452652000915 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652000916 putative substrate translocation pore; other site 452652000917 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652000918 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652000919 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 452652000920 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 452652000921 active site 452652000922 metal binding site [ion binding]; metal-binding site 452652000923 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652000924 salt bridge; other site 452652000925 non-specific DNA binding site [nucleotide binding]; other site 452652000926 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 452652000927 sequence-specific DNA binding site [nucleotide binding]; other site 452652000928 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652000929 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652000930 DNA binding residues [nucleotide binding] 452652000931 dimerization interface [polypeptide binding]; other site 452652000932 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 452652000933 active site 452652000934 8-oxo-dGMP binding site [chemical binding]; other site 452652000935 nudix motif; other site 452652000936 metal binding site [ion binding]; metal-binding site 452652000937 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 452652000938 nudix motif; other site 452652000939 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 452652000940 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 452652000941 Putative Ig domain; Region: He_PIG; pfam05345 452652000942 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 452652000943 Small secreted domain (DUF320); Region: DUF320; pfam03777 452652000944 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 452652000945 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 452652000946 Predicted transcriptional regulators [Transcription]; Region: COG1733 452652000947 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 452652000948 Uncharacterized conserved protein [Function unknown]; Region: COG1359 452652000949 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 452652000950 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 452652000951 active site 452652000952 ATP binding site [chemical binding]; other site 452652000953 substrate binding site [chemical binding]; other site 452652000954 activation loop (A-loop); other site 452652000955 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 452652000956 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 452652000957 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 452652000958 catalytic residue [active] 452652000959 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 452652000960 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 452652000961 ligand binding site [chemical binding]; other site 452652000962 flexible hinge region; other site 452652000963 tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238 452652000964 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 452652000965 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 452652000966 catalytic residue [active] 452652000967 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 452652000968 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 452652000969 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452652000970 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 452652000971 Coenzyme A binding pocket [chemical binding]; other site 452652000972 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 452652000973 active site 452652000974 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652000975 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 452652000976 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 452652000977 Beta-lactamase; Region: Beta-lactamase; pfam00144 452652000978 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 452652000979 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 452652000980 Beta-lactamase; Region: Beta-lactamase; pfam00144 452652000981 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 452652000982 Cupin superfamily protein; Region: Cupin_4; pfam08007 452652000983 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 452652000984 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 452652000985 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 452652000986 active site 452652000987 zinc binding site [ion binding]; other site 452652000988 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 452652000989 active site 452652000990 CsbD-like; Region: CsbD; cl17424 452652000991 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 452652000992 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 452652000993 ATP binding site [chemical binding]; other site 452652000994 Mg2+ binding site [ion binding]; other site 452652000995 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 452652000996 anti sigma factor interaction site; other site 452652000997 regulatory phosphorylation site [posttranslational modification]; other site 452652000998 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452652000999 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452652001000 dimer interface [polypeptide binding]; other site 452652001001 phosphorylation site [posttranslational modification] 452652001002 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652001003 ATP binding site [chemical binding]; other site 452652001004 Mg2+ binding site [ion binding]; other site 452652001005 G-X-G motif; other site 452652001006 Response regulator receiver domain; Region: Response_reg; pfam00072 452652001007 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652001008 active site 452652001009 phosphorylation site [posttranslational modification] 452652001010 intermolecular recognition site; other site 452652001011 dimerization interface [polypeptide binding]; other site 452652001012 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 452652001013 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 452652001014 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 452652001015 dimerization interface [polypeptide binding]; other site 452652001016 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 452652001017 dimerization interface [polypeptide binding]; other site 452652001018 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 452652001019 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 452652001020 dimerization interface [polypeptide binding]; other site 452652001021 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 452652001022 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 452652001023 dimerization interface [polypeptide binding]; other site 452652001024 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 452652001025 dimerization interface [polypeptide binding]; other site 452652001026 GAF domain; Region: GAF_2; pfam13185 452652001027 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 452652001028 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 452652001029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652001030 ATP binding site [chemical binding]; other site 452652001031 Mg2+ binding site [ion binding]; other site 452652001032 G-X-G motif; other site 452652001033 Response regulator receiver domain; Region: Response_reg; pfam00072 452652001034 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652001035 active site 452652001036 phosphorylation site [posttranslational modification] 452652001037 intermolecular recognition site; other site 452652001038 dimerization interface [polypeptide binding]; other site 452652001039 ANTAR domain; Region: ANTAR; pfam03861 452652001040 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452652001041 PAS fold; Region: PAS_3; pfam08447 452652001042 putative active site [active] 452652001043 heme pocket [chemical binding]; other site 452652001044 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 452652001045 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 452652001046 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 452652001047 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 452652001048 FAD binding pocket [chemical binding]; other site 452652001049 conserved FAD binding motif [chemical binding]; other site 452652001050 phosphate binding motif [ion binding]; other site 452652001051 beta-alpha-beta structure motif; other site 452652001052 NAD binding pocket [chemical binding]; other site 452652001053 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 452652001054 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 452652001055 Moco binding site; other site 452652001056 metal coordination site [ion binding]; other site 452652001057 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 452652001058 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 452652001059 Moco binding site; other site 452652001060 metal coordination site [ion binding]; other site 452652001061 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 452652001062 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 452652001063 dimer interface [polypeptide binding]; other site 452652001064 active site 452652001065 heme binding site [chemical binding]; other site 452652001066 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 452652001067 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 452652001068 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 452652001069 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 452652001070 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 452652001071 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652001072 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 452652001073 Walker A/P-loop; other site 452652001074 ATP binding site [chemical binding]; other site 452652001075 Q-loop/lid; other site 452652001076 ABC transporter signature motif; other site 452652001077 Walker B; other site 452652001078 D-loop; other site 452652001079 H-loop/switch region; other site 452652001080 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 452652001081 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 452652001082 Transcriptional regulators [Transcription]; Region: MarR; COG1846 452652001083 MarR family; Region: MarR_2; pfam12802 452652001084 Transcription factor WhiB; Region: Whib; pfam02467 452652001085 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 452652001086 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 452652001087 anti sigma factor interaction site; other site 452652001088 regulatory phosphorylation site [posttranslational modification]; other site 452652001089 B12 binding domain; Region: B12-binding_2; pfam02607 452652001090 B12 binding domain; Region: B12-binding; pfam02310 452652001091 GAF domain; Region: GAF; cl17456 452652001092 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 452652001093 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 452652001094 anti sigma factor interaction site; other site 452652001095 regulatory phosphorylation site [posttranslational modification]; other site 452652001096 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 452652001097 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 452652001098 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 452652001099 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 452652001100 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 452652001101 dimerization interface [polypeptide binding]; other site 452652001102 DPS ferroxidase diiron center [ion binding]; other site 452652001103 ion pore; other site 452652001104 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 452652001105 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 452652001106 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 452652001107 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 452652001108 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 452652001109 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 452652001110 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 452652001111 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452652001112 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452652001113 dimer interface [polypeptide binding]; other site 452652001114 phosphorylation site [posttranslational modification] 452652001115 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652001116 ATP binding site [chemical binding]; other site 452652001117 Mg2+ binding site [ion binding]; other site 452652001118 G-X-G motif; other site 452652001119 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 452652001120 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652001121 active site 452652001122 phosphorylation site [posttranslational modification] 452652001123 intermolecular recognition site; other site 452652001124 Response regulator receiver domain; Region: Response_reg; pfam00072 452652001125 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652001126 active site 452652001127 phosphorylation site [posttranslational modification] 452652001128 intermolecular recognition site; other site 452652001129 dimerization interface [polypeptide binding]; other site 452652001130 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 452652001131 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 452652001132 anti sigma factor interaction site; other site 452652001133 regulatory phosphorylation site [posttranslational modification]; other site 452652001134 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 452652001135 active site 452652001136 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 452652001137 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 452652001138 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 452652001139 active site 452652001140 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 452652001141 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 452652001142 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 452652001143 PLD-like domain; Region: PLDc_2; pfam13091 452652001144 putative active site [active] 452652001145 catalytic site [active] 452652001146 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 452652001147 PLD-like domain; Region: PLDc_2; pfam13091 452652001148 putative active site [active] 452652001149 catalytic site [active] 452652001150 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 452652001151 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 452652001152 Sulfate transporter family; Region: Sulfate_transp; pfam00916 452652001153 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 452652001154 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 452652001155 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 452652001156 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 452652001157 catalytic residue [active] 452652001158 multidrug resistance protein MdtH; Provisional; Region: PRK11646 452652001159 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 452652001160 nucleotide binding site [chemical binding]; other site 452652001161 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 452652001162 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 452652001163 Transposase; Region: HTH_Tnp_1; cl17663 452652001164 putative transposase OrfB; Reviewed; Region: PHA02517 452652001165 HTH-like domain; Region: HTH_21; pfam13276 452652001166 Integrase core domain; Region: rve; pfam00665 452652001167 Integrase core domain; Region: rve_3; pfam13683 452652001168 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 452652001169 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 452652001170 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 452652001171 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 452652001172 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 452652001173 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 452652001174 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 452652001175 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cl08044 452652001176 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 452652001177 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 452652001178 Protein of unknown function DUF91; Region: DUF91; cl00709 452652001179 Protein of unknown function DUF91; Region: DUF91; cl00709 452652001180 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 452652001181 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 452652001182 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 452652001183 potential frameshift: common BLAST hit: gi|345013420|ref|YP_004815774.1| transposase IS4 family protein 452652001184 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 452652001185 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 452652001186 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 452652001187 nucleotide binding site/active site [active] 452652001188 HIT family signature motif; other site 452652001189 catalytic residue [active] 452652001190 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 452652001191 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 452652001192 active site 452652001193 homodimer interface [polypeptide binding]; other site 452652001194 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 452652001195 prolyl-tRNA synthetase; Provisional; Region: PRK09194 452652001196 motif 1; other site 452652001197 dimer interface [polypeptide binding]; other site 452652001198 active site 452652001199 motif 2; other site 452652001200 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 452652001201 active site 452652001202 motif 3; other site 452652001203 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 452652001204 anticodon binding site; other site 452652001205 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 452652001206 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 452652001207 WbqC-like protein family; Region: WbqC; pfam08889 452652001208 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 452652001209 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 452652001210 trimer interface [polypeptide binding]; other site 452652001211 active site 452652001212 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 452652001213 trimer interface [polypeptide binding]; other site 452652001214 active site 452652001215 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 452652001216 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 452652001217 active site 452652001218 metal binding site [ion binding]; metal-binding site 452652001219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652001220 S-adenosylmethionine binding site [chemical binding]; other site 452652001221 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452652001222 Coenzyme A binding pocket [chemical binding]; other site 452652001223 HD domain; Region: HD_3; pfam13023 452652001224 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 452652001225 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652001226 non-specific DNA binding site [nucleotide binding]; other site 452652001227 salt bridge; other site 452652001228 sequence-specific DNA binding site [nucleotide binding]; other site 452652001229 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 452652001230 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 452652001231 potential frameshift: common BLAST hit: gi|345013420|ref|YP_004815774.1| transposase IS4 family protein 452652001232 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 452652001233 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 452652001234 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 452652001235 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 452652001236 DNA binding site [nucleotide binding] 452652001237 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 452652001238 hydroperoxidase II; Provisional; Region: katE; PRK11249 452652001239 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 452652001240 heme binding pocket [chemical binding]; other site 452652001241 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 452652001242 conserved cys residue [active] 452652001243 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 452652001244 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 452652001245 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 452652001246 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 452652001247 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 452652001248 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 452652001249 catalytic residue [active] 452652001250 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 452652001251 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 452652001252 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 452652001253 Walker A/P-loop; other site 452652001254 ATP binding site [chemical binding]; other site 452652001255 Q-loop/lid; other site 452652001256 ABC transporter signature motif; other site 452652001257 Walker B; other site 452652001258 D-loop; other site 452652001259 H-loop/switch region; other site 452652001260 Histidine kinase; Region: HisKA_3; pfam07730 452652001261 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 452652001262 ATP binding site [chemical binding]; other site 452652001263 Mg2+ binding site [ion binding]; other site 452652001264 G-X-G motif; other site 452652001265 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652001266 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652001267 active site 452652001268 phosphorylation site [posttranslational modification] 452652001269 intermolecular recognition site; other site 452652001270 dimerization interface [polypeptide binding]; other site 452652001271 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652001272 DNA binding residues [nucleotide binding] 452652001273 dimerization interface [polypeptide binding]; other site 452652001274 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 452652001275 dimerization interface [polypeptide binding]; other site 452652001276 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452652001277 dimer interface [polypeptide binding]; other site 452652001278 phosphorylation site [posttranslational modification] 452652001279 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652001280 ATP binding site [chemical binding]; other site 452652001281 Mg2+ binding site [ion binding]; other site 452652001282 G-X-G motif; other site 452652001283 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 452652001284 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652001285 active site 452652001286 phosphorylation site [posttranslational modification] 452652001287 intermolecular recognition site; other site 452652001288 dimerization interface [polypeptide binding]; other site 452652001289 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 452652001290 DNA binding site [nucleotide binding] 452652001291 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 452652001292 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 452652001293 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 452652001294 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 452652001295 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 452652001296 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 452652001297 active site 452652001298 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 452652001299 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 452652001300 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652001301 active site 452652001302 phosphorylation site [posttranslational modification] 452652001303 intermolecular recognition site; other site 452652001304 dimerization interface [polypeptide binding]; other site 452652001305 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 452652001306 PAS fold; Region: PAS_7; pfam12860 452652001307 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452652001308 putative active site [active] 452652001309 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452652001310 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652001311 ATP binding site [chemical binding]; other site 452652001312 Mg2+ binding site [ion binding]; other site 452652001313 G-X-G motif; other site 452652001314 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 452652001315 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 452652001316 Walker A/P-loop; other site 452652001317 ATP binding site [chemical binding]; other site 452652001318 Q-loop/lid; other site 452652001319 ABC transporter signature motif; other site 452652001320 Walker B; other site 452652001321 D-loop; other site 452652001322 H-loop/switch region; other site 452652001323 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 452652001324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652001325 dimer interface [polypeptide binding]; other site 452652001326 conserved gate region; other site 452652001327 putative PBP binding loops; other site 452652001328 ABC-ATPase subunit interface; other site 452652001329 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 452652001330 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 452652001331 membrane-bound complex binding site; other site 452652001332 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452652001333 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 452652001334 Catalytic domain of Protein Kinases; Region: PKc; cd00180 452652001335 active site 452652001336 ATP binding site [chemical binding]; other site 452652001337 substrate binding site [chemical binding]; other site 452652001338 activation loop (A-loop); other site 452652001339 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 452652001340 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 452652001341 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 452652001342 MarR family; Region: MarR_2; pfam12802 452652001343 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 452652001344 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 452652001345 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 452652001346 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 452652001347 Uncharacterized conserved protein [Function unknown]; Region: COG1359 452652001348 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 452652001349 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 452652001350 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 452652001351 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 452652001352 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 452652001353 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 452652001354 Transcriptional regulators [Transcription]; Region: PurR; COG1609 452652001355 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 452652001356 DNA binding site [nucleotide binding] 452652001357 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 452652001358 Melibiase; Region: Melibiase; pfam02065 452652001359 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 452652001360 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 452652001361 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652001362 dimer interface [polypeptide binding]; other site 452652001363 conserved gate region; other site 452652001364 putative PBP binding loops; other site 452652001365 ABC-ATPase subunit interface; other site 452652001366 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652001367 dimer interface [polypeptide binding]; other site 452652001368 conserved gate region; other site 452652001369 putative PBP binding loops; other site 452652001370 ABC-ATPase subunit interface; other site 452652001371 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 452652001372 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 452652001373 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 452652001374 putative metal binding site [ion binding]; other site 452652001375 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 452652001376 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 452652001377 MarR family; Region: MarR_2; cl17246 452652001378 EamA-like transporter family; Region: EamA; pfam00892 452652001379 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 452652001380 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 452652001381 active site 452652001382 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 452652001383 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 452652001384 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 452652001385 Walker A/P-loop; other site 452652001386 ATP binding site [chemical binding]; other site 452652001387 Q-loop/lid; other site 452652001388 ABC transporter signature motif; other site 452652001389 Walker B; other site 452652001390 D-loop; other site 452652001391 H-loop/switch region; other site 452652001392 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 452652001393 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 452652001394 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 452652001395 Walker A/P-loop; other site 452652001396 ATP binding site [chemical binding]; other site 452652001397 Q-loop/lid; other site 452652001398 ABC transporter signature motif; other site 452652001399 Walker B; other site 452652001400 D-loop; other site 452652001401 H-loop/switch region; other site 452652001402 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 452652001403 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 452652001404 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652001405 dimer interface [polypeptide binding]; other site 452652001406 conserved gate region; other site 452652001407 putative PBP binding loops; other site 452652001408 ABC-ATPase subunit interface; other site 452652001409 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 452652001410 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652001411 dimer interface [polypeptide binding]; other site 452652001412 conserved gate region; other site 452652001413 putative PBP binding loops; other site 452652001414 ABC-ATPase subunit interface; other site 452652001415 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 452652001416 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 452652001417 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 452652001418 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 452652001419 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 452652001420 active site 452652001421 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 452652001422 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 452652001423 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 452652001424 active site 452652001425 homodimer interface [polypeptide binding]; other site 452652001426 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 452652001427 DNA binding residues [nucleotide binding] 452652001428 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 452652001429 B12 binding domain; Region: B12-binding_2; cl03653 452652001430 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 452652001431 hydrophobic ligand binding site; other site 452652001432 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 452652001433 hydroxyglutarate oxidase; Provisional; Region: PRK11728 452652001434 Protein of unknown function (DUF1365); Region: DUF1365; cl17838 452652001435 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 452652001436 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652001437 S-adenosylmethionine binding site [chemical binding]; other site 452652001438 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 452652001439 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 452652001440 RNA binding site [nucleotide binding]; other site 452652001441 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 452652001442 RNA binding site [nucleotide binding]; other site 452652001443 Putative zinc-finger; Region: zf-HC2; pfam13490 452652001444 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 452652001445 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652001446 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452652001447 DNA binding residues [nucleotide binding] 452652001448 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 452652001449 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 452652001450 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 452652001451 NAD binding site [chemical binding]; other site 452652001452 catalytic Zn binding site [ion binding]; other site 452652001453 substrate binding site [chemical binding]; other site 452652001454 structural Zn binding site [ion binding]; other site 452652001455 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 452652001456 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 452652001457 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 452652001458 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 452652001459 Cytochrome P450; Region: p450; cl12078 452652001460 Predicted membrane protein [Function unknown]; Region: COG2119 452652001461 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 452652001462 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 452652001463 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 452652001464 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 452652001465 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 452652001466 active site 452652001467 Zn binding site [ion binding]; other site 452652001468 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 452652001469 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 452652001470 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 452652001471 30S subunit binding site; other site 452652001472 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 452652001473 putative catalytic site [active] 452652001474 putative metal binding site [ion binding]; other site 452652001475 putative phosphate binding site [ion binding]; other site 452652001476 AAA domain; Region: AAA_18; pfam13238 452652001477 RNA helicase; Region: RNA_helicase; pfam00910 452652001478 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452652001479 binding surface 452652001480 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452652001481 TPR motif; other site 452652001482 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652001483 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652001484 DNA binding residues [nucleotide binding] 452652001485 dimerization interface [polypeptide binding]; other site 452652001486 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 452652001487 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 452652001488 active site 452652001489 Zn binding site [ion binding]; other site 452652001490 Cupin domain; Region: Cupin_2; cl17218 452652001491 Rrf2 family protein; Region: rrf2_super; TIGR00738 452652001492 Transcriptional regulator; Region: Rrf2; pfam02082 452652001493 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_9; cd08496 452652001494 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 452652001495 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 452652001496 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652001497 dimer interface [polypeptide binding]; other site 452652001498 conserved gate region; other site 452652001499 putative PBP binding loops; other site 452652001500 ABC-ATPase subunit interface; other site 452652001501 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 452652001502 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652001503 dimer interface [polypeptide binding]; other site 452652001504 conserved gate region; other site 452652001505 ABC-ATPase subunit interface; other site 452652001506 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 452652001507 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 452652001508 Walker A/P-loop; other site 452652001509 ATP binding site [chemical binding]; other site 452652001510 Q-loop/lid; other site 452652001511 ABC transporter signature motif; other site 452652001512 Walker B; other site 452652001513 D-loop; other site 452652001514 H-loop/switch region; other site 452652001515 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 452652001516 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 452652001517 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 452652001518 Walker A/P-loop; other site 452652001519 ATP binding site [chemical binding]; other site 452652001520 Q-loop/lid; other site 452652001521 ABC transporter signature motif; other site 452652001522 Walker B; other site 452652001523 D-loop; other site 452652001524 H-loop/switch region; other site 452652001525 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 452652001526 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 452652001527 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 452652001528 molybdopterin cofactor binding site; other site 452652001529 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 452652001530 molybdopterin cofactor binding site; other site 452652001531 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 452652001532 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 452652001533 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 452652001534 active site 452652001535 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 452652001536 dimer interface [polypeptide binding]; other site 452652001537 non-prolyl cis peptide bond; other site 452652001538 insertion regions; other site 452652001539 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 452652001540 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 452652001541 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 452652001542 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 452652001543 active site 452652001544 dimer interface [polypeptide binding]; other site 452652001545 non-prolyl cis peptide bond; other site 452652001546 insertion regions; other site 452652001547 Protein of unknown function (DUF3344); Region: DUF3344; pfam11824 452652001548 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 452652001549 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 452652001550 sugar binding site [chemical binding]; other site 452652001551 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 452652001552 active site 452652001553 catalytic residues [active] 452652001554 twin-arg-translocated uncharacterized repeat protein; Region: RR_plus_rpt_1; TIGR03808 452652001555 AMP-binding domain protein; Validated; Region: PRK08315 452652001556 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452652001557 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 452652001558 acyl-activating enzyme (AAE) consensus motif; other site 452652001559 putative AMP binding site [chemical binding]; other site 452652001560 putative active site [active] 452652001561 putative CoA binding site [chemical binding]; other site 452652001562 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 452652001563 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 452652001564 active site 452652001565 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 452652001566 active site 452652001567 catalytic residues [active] 452652001568 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 452652001569 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 452652001570 putative sugar binding sites [chemical binding]; other site 452652001571 Q-X-W motif; other site 452652001572 glycoside hydrolase family 64: beta-1,3-glucanase B (GluB)-like; Region: GH64-GluB-like; cd09220 452652001573 substrate binding pocket [chemical binding]; other site 452652001574 catalytic residues [active] 452652001575 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 452652001576 metal binding site [ion binding]; metal-binding site 452652001577 ligand binding site [chemical binding]; other site 452652001578 Spherulation-specific family 4; Region: Spherulin4; pfam12138 452652001579 benzoate transport; Region: 2A0115; TIGR00895 452652001580 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652001581 putative substrate translocation pore; other site 452652001582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652001583 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452652001584 PAS fold; Region: PAS_3; pfam08447 452652001585 putative active site [active] 452652001586 heme pocket [chemical binding]; other site 452652001587 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 452652001588 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 452652001589 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 452652001590 dimerization interface [polypeptide binding]; other site 452652001591 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 452652001592 dimerization interface [polypeptide binding]; other site 452652001593 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 452652001594 dimerization interface [polypeptide binding]; other site 452652001595 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 452652001596 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 452652001597 dimerization interface [polypeptide binding]; other site 452652001598 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 452652001599 dimerization interface [polypeptide binding]; other site 452652001600 GAF domain; Region: GAF_2; pfam13185 452652001601 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 452652001602 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 452652001603 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652001604 ATP binding site [chemical binding]; other site 452652001605 Mg2+ binding site [ion binding]; other site 452652001606 G-X-G motif; other site 452652001607 Response regulator receiver domain; Region: Response_reg; pfam00072 452652001608 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652001609 active site 452652001610 phosphorylation site [posttranslational modification] 452652001611 intermolecular recognition site; other site 452652001612 dimerization interface [polypeptide binding]; other site 452652001613 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 452652001614 anti sigma factor interaction site; other site 452652001615 regulatory phosphorylation site [posttranslational modification]; other site 452652001616 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 452652001617 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652001618 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 452652001619 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452652001620 DNA binding residues [nucleotide binding] 452652001621 Cupin domain; Region: Cupin_2; cl17218 452652001622 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 452652001623 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 452652001624 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 452652001625 catalytic residues [active] 452652001626 catalytic nucleophile [active] 452652001627 Recombinase; Region: Recombinase; pfam07508 452652001628 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 452652001629 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 452652001630 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652001631 non-specific DNA binding site [nucleotide binding]; other site 452652001632 salt bridge; other site 452652001633 sequence-specific DNA binding site [nucleotide binding]; other site 452652001634 putative ATP-grasp target RiPP; Region: GRASP_targ; TIGR04186 452652001635 ATP-grasp domain; Region: ATP-grasp_4; cl17255 452652001636 methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188 452652001637 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652001638 S-adenosylmethionine binding site [chemical binding]; other site 452652001639 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 452652001640 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 452652001641 DNA-binding site [nucleotide binding]; DNA binding site 452652001642 SnoaL-like domain; Region: SnoaL_3; pfam13474 452652001643 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 452652001644 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652001645 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652001646 active site 452652001647 phosphorylation site [posttranslational modification] 452652001648 intermolecular recognition site; other site 452652001649 dimerization interface [polypeptide binding]; other site 452652001650 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652001651 DNA binding residues [nucleotide binding] 452652001652 dimerization interface [polypeptide binding]; other site 452652001653 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 452652001654 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 452652001655 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 452652001656 motif II; other site 452652001657 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 452652001658 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 452652001659 Amidinotransferase; Region: Amidinotransf; cl12043 452652001660 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 452652001661 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 452652001662 putative methyltransferase; Provisional; Region: PRK14967 452652001663 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 452652001664 CDGSH-type zinc finger. Function unknown; Region: ZnF_CDGSH; smart00704 452652001665 ANTAR domain; Region: ANTAR; pfam03861 452652001666 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 452652001667 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 452652001668 intracellular protease, PfpI family; Region: PfpI; TIGR01382 452652001669 proposed catalytic triad [active] 452652001670 conserved cys residue [active] 452652001671 Domain of unknown function (DUF427); Region: DUF427; pfam04248 452652001672 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 452652001673 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 452652001674 DNA binding residues [nucleotide binding] 452652001675 putative dimer interface [polypeptide binding]; other site 452652001676 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 452652001677 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652001678 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 452652001679 active site 452652001680 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 452652001681 non-prolyl cis peptide bond; other site 452652001682 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 452652001683 Helix-turn-helix domain; Region: HTH_18; pfam12833 452652001684 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452652001685 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 452652001686 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 452652001687 putative hydrophobic ligand binding site [chemical binding]; other site 452652001688 RibD C-terminal domain; Region: RibD_C; cl17279 452652001689 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 452652001690 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 452652001691 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 452652001692 Sulfate transporter family; Region: Sulfate_transp; pfam00916 452652001693 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 452652001694 anti sigma factor interaction site; other site 452652001695 regulatory phosphorylation site [posttranslational modification]; other site 452652001696 hypothetical protein; Provisional; Region: PRK06834 452652001697 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 452652001698 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 452652001699 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 452652001700 active site 452652001701 motif I; other site 452652001702 motif II; other site 452652001703 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 452652001704 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 452652001705 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 452652001706 motif II; other site 452652001707 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 452652001708 active site clefts [active] 452652001709 zinc binding site [ion binding]; other site 452652001710 dimer interface [polypeptide binding]; other site 452652001711 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 452652001712 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 452652001713 putative active site [active] 452652001714 putative FMN binding site [chemical binding]; other site 452652001715 putative substrate binding site [chemical binding]; other site 452652001716 putative catalytic residue [active] 452652001717 putative acyltransferase; Provisional; Region: PRK05790 452652001718 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 452652001719 dimer interface [polypeptide binding]; other site 452652001720 active site 452652001721 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652001722 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652001723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652001724 metabolite-proton symporter; Region: 2A0106; TIGR00883 452652001725 putative substrate translocation pore; other site 452652001726 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 452652001727 Cytochrome P450; Region: p450; cl12078 452652001728 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 452652001729 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 452652001730 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 452652001731 tetramer interface [polypeptide binding]; other site 452652001732 active site 452652001733 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 452652001734 Catalytic domain of Protein Kinases; Region: PKc; cd00180 452652001735 active site 452652001736 ATP binding site [chemical binding]; other site 452652001737 substrate binding site [chemical binding]; other site 452652001738 activation loop (A-loop); other site 452652001739 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 452652001740 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652001741 active site 452652001742 phosphorylation site [posttranslational modification] 452652001743 intermolecular recognition site; other site 452652001744 dimerization interface [polypeptide binding]; other site 452652001745 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 452652001746 CHASE3 domain; Region: CHASE3; pfam05227 452652001747 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 452652001748 dimerization interface [polypeptide binding]; other site 452652001749 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452652001750 dimer interface [polypeptide binding]; other site 452652001751 phosphorylation site [posttranslational modification] 452652001752 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652001753 ATP binding site [chemical binding]; other site 452652001754 Mg2+ binding site [ion binding]; other site 452652001755 G-X-G motif; other site 452652001756 Response regulator receiver domain; Region: Response_reg; pfam00072 452652001757 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652001758 active site 452652001759 phosphorylation site [posttranslational modification] 452652001760 intermolecular recognition site; other site 452652001761 dimerization interface [polypeptide binding]; other site 452652001762 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 452652001763 beta-galactosidase; Region: BGL; TIGR03356 452652001764 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 452652001765 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 452652001766 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 452652001767 ligand binding site [chemical binding]; other site 452652001768 flexible hinge region; other site 452652001769 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 452652001770 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 452652001771 Transposase; Region: DEDD_Tnp_IS110; pfam01548 452652001772 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 452652001773 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 452652001774 Helix-turn-helix domain; Region: HTH_17; pfam12728 452652001775 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 452652001776 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 452652001777 oligomer interface [polypeptide binding]; other site 452652001778 metal binding site [ion binding]; metal-binding site 452652001779 metal binding site [ion binding]; metal-binding site 452652001780 putative Cl binding site [ion binding]; other site 452652001781 basic sphincter; other site 452652001782 hydrophobic gate; other site 452652001783 periplasmic entrance; other site 452652001784 short chain dehydrogenase; Provisional; Region: PRK08303 452652001785 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652001786 NAD(P) binding site [chemical binding]; other site 452652001787 active site 452652001788 HTH domain; Region: HTH_11; pfam08279 452652001789 WYL domain; Region: WYL; pfam13280 452652001790 HEAT repeats; Region: HEAT_2; pfam13646 452652001791 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 452652001792 active site 452652001793 catalytic residues [active] 452652001794 PhoD-like phosphatase; Region: PhoD; pfam09423 452652001795 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 452652001796 putative active site [active] 452652001797 putative metal binding site [ion binding]; other site 452652001798 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 452652001799 Beta-lactamase; Region: Beta-lactamase; pfam00144 452652001800 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 452652001801 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652001802 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652001803 active site 452652001804 phosphorylation site [posttranslational modification] 452652001805 intermolecular recognition site; other site 452652001806 dimerization interface [polypeptide binding]; other site 452652001807 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652001808 DNA binding residues [nucleotide binding] 452652001809 dimerization interface [polypeptide binding]; other site 452652001810 alpha-galactosidase; Region: PLN02808; cl17638 452652001811 alpha-galactosidase; Region: PLN02808; cl17638 452652001812 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 452652001813 NlpC/P60 family; Region: NLPC_P60; cl17555 452652001814 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 452652001815 active site 452652001816 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 452652001817 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 452652001818 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652001819 non-specific DNA binding site [nucleotide binding]; other site 452652001820 salt bridge; other site 452652001821 sequence-specific DNA binding site [nucleotide binding]; other site 452652001822 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 452652001823 FOG: WD40 repeat [General function prediction only]; Region: COG2319 452652001824 structural tetrad; other site 452652001825 FOG: WD40 repeat [General function prediction only]; Region: COG2319 452652001826 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 452652001827 structural tetrad; other site 452652001828 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 452652001829 active site 452652001830 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 452652001831 dimer interface [polypeptide binding]; other site 452652001832 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 452652001833 Ligand Binding Site [chemical binding]; other site 452652001834 Molecular Tunnel; other site 452652001835 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 452652001836 ATP-grasp domain; Region: ATP-grasp_4; cl17255 452652001837 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 452652001838 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 452652001839 DXD motif; other site 452652001840 HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7 452652001841 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 452652001842 motif II; other site 452652001843 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 452652001844 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 452652001845 active site 452652001846 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 452652001847 homodimer interface [polypeptide binding]; other site 452652001848 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 452652001849 active site 452652001850 metal binding site [ion binding]; metal-binding site 452652001851 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 452652001852 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652001853 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652001854 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 452652001855 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 452652001856 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 452652001857 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 452652001858 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 452652001859 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 452652001860 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 452652001861 Transcriptional regulators [Transcription]; Region: MarR; COG1846 452652001862 MarR family; Region: MarR_2; cl17246 452652001863 Predicted transcriptional regulators [Transcription]; Region: COG1733 452652001864 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 452652001865 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 452652001866 catalytic triad [active] 452652001867 H+ Antiporter protein; Region: 2A0121; TIGR00900 452652001868 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 452652001869 Beta-lactamase; Region: Beta-lactamase; cl17358 452652001870 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 452652001871 Putative catalytic NodB homology domain of uncharacterized BH0857 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH0857_like; cd10955 452652001872 NodB motif; other site 452652001873 putative active site [active] 452652001874 putative catalytic site [active] 452652001875 calcium/proton exchanger; Region: caca2; TIGR00846 452652001876 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 452652001877 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 452652001878 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 452652001879 glutaminase active site [active] 452652001880 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 452652001881 dimer interface [polypeptide binding]; other site 452652001882 active site 452652001883 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 452652001884 dimer interface [polypeptide binding]; other site 452652001885 active site 452652001886 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 452652001887 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 452652001888 catalytic residue [active] 452652001889 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 452652001890 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 452652001891 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 452652001892 Coenzyme A binding pocket [chemical binding]; other site 452652001893 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 452652001894 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 452652001895 Ribosomal protein S27a; Region: Ribosomal_S27; cl00876 452652001896 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 452652001897 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 452652001898 catalytic triad [active] 452652001899 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 452652001900 phosphofructokinase; Region: PFK_mixed; TIGR02483 452652001901 active site 452652001902 ADP/pyrophosphate binding site [chemical binding]; other site 452652001903 dimerization interface [polypeptide binding]; other site 452652001904 allosteric effector site; other site 452652001905 fructose-1,6-bisphosphate binding site; other site 452652001906 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 452652001907 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 452652001908 putative ligand binding site [chemical binding]; other site 452652001909 putative NAD binding site [chemical binding]; other site 452652001910 catalytic site [active] 452652001911 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 452652001912 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 452652001913 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 452652001914 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 452652001915 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 452652001916 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 452652001917 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 452652001918 heme binding site [chemical binding]; other site 452652001919 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 452652001920 Predicted membrane protein [Function unknown]; Region: COG4325 452652001921 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 452652001922 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652001923 active site 452652001924 MarR family; Region: MarR_2; cl17246 452652001925 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 452652001926 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 452652001927 putative deacylase active site [active] 452652001928 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 452652001929 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652001930 non-specific DNA binding site [nucleotide binding]; other site 452652001931 salt bridge; other site 452652001932 sequence-specific DNA binding site [nucleotide binding]; other site 452652001933 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 452652001934 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 452652001935 hypothetical protein; Provisional; Region: PRK12338 452652001936 AAA domain; Region: AAA_17; pfam13207 452652001937 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652001938 S-adenosylmethionine binding site [chemical binding]; other site 452652001939 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 452652001940 active site 452652001941 dimer interface [polypeptide binding]; other site 452652001942 motif 2; other site 452652001943 motif 3; other site 452652001944 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 452652001945 Protein of unknown function (DUF3069); Region: DUF3069; pfam11269 452652001946 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 452652001947 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 452652001948 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652001949 WHG domain; Region: WHG; pfam13305 452652001950 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 452652001951 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 452652001952 phosphate binding site [ion binding]; other site 452652001953 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 452652001954 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 452652001955 potential catalytic triad [active] 452652001956 conserved cys residue [active] 452652001957 Clp amino terminal domain; Region: Clp_N; pfam02861 452652001958 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 452652001959 putative catalytic site [active] 452652001960 metal binding site A [ion binding]; metal-binding site 452652001961 phosphate binding site [ion binding]; other site 452652001962 metal binding site C [ion binding]; metal-binding site 452652001963 metal binding site B [ion binding]; metal-binding site 452652001964 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 452652001965 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 452652001966 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 452652001967 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452652001968 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 452652001969 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 452652001970 NAD(P) binding site [chemical binding]; other site 452652001971 catalytic residues [active] 452652001972 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 452652001973 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 452652001974 Ligand Binding Site [chemical binding]; other site 452652001975 Molecular Tunnel; other site 452652001976 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 452652001977 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 452652001978 NAD(P) binding site [chemical binding]; other site 452652001979 catalytic residues [active] 452652001980 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 452652001981 substrate binding site [chemical binding]; other site 452652001982 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 452652001983 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452652001984 Predicted ATPase [General function prediction only]; Region: COG3911 452652001985 AAA domain; Region: AAA_28; pfam13521 452652001986 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 452652001987 Ca2+ binding site [ion binding]; other site 452652001988 EF-hand domain pair; Region: EF_hand_5; pfam13499 452652001989 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 452652001990 Ca2+ binding site [ion binding]; other site 452652001991 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 452652001992 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 452652001993 molybdopterin cofactor binding site; other site 452652001994 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 452652001995 molybdopterin cofactor binding site; other site 452652001996 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 452652001997 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 452652001998 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 452652001999 active site 452652002000 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 452652002001 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 452652002002 dinuclear metal binding motif [ion binding]; other site 452652002003 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 452652002004 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 452652002005 catalytic residue [active] 452652002006 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 452652002007 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 452652002008 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 452652002009 aminotransferase AlaT; Validated; Region: PRK09265 452652002010 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 452652002011 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652002012 homodimer interface [polypeptide binding]; other site 452652002013 catalytic residue [active] 452652002014 threonine dehydratase; Provisional; Region: PRK08246 452652002015 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 452652002016 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 452652002017 catalytic residue [active] 452652002018 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 452652002019 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 452652002020 seryl-tRNA synthetase; Provisional; Region: PRK05431 452652002021 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 452652002022 motif 1; other site 452652002023 dimer interface [polypeptide binding]; other site 452652002024 active site 452652002025 motif 2; other site 452652002026 motif 3; other site 452652002027 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 452652002028 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 452652002029 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 452652002030 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 452652002031 LytB protein; Region: LYTB; cl00507 452652002032 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 452652002033 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 452652002034 nudix motif; other site 452652002035 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 452652002036 nudix motif; other site 452652002037 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 452652002038 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 452652002039 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 452652002040 NAD binding site [chemical binding]; other site 452652002041 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 452652002042 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652002043 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652002044 active site 452652002045 phosphorylation site [posttranslational modification] 452652002046 intermolecular recognition site; other site 452652002047 dimerization interface [polypeptide binding]; other site 452652002048 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652002049 DNA binding residues [nucleotide binding] 452652002050 dimerization interface [polypeptide binding]; other site 452652002051 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 452652002052 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 452652002053 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 452652002054 TIGR03086 family protein; Region: TIGR03086 452652002055 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 452652002056 AAA domain; Region: AAA_33; pfam13671 452652002057 AAA domain; Region: AAA_17; pfam13207 452652002058 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452652002059 Coenzyme A binding pocket [chemical binding]; other site 452652002060 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 452652002061 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 452652002062 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 452652002063 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 452652002064 Walker A motif; other site 452652002065 ATP binding site [chemical binding]; other site 452652002066 Walker B motif; other site 452652002067 arginine finger; other site 452652002068 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 452652002069 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 452652002070 metal ion-dependent adhesion site (MIDAS); other site 452652002071 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 452652002072 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 452652002073 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 452652002074 DNA binding residues [nucleotide binding] 452652002075 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 452652002076 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 452652002077 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 452652002078 Histidine kinase; Region: HisKA_3; pfam07730 452652002079 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652002080 ATP binding site [chemical binding]; other site 452652002081 Mg2+ binding site [ion binding]; other site 452652002082 G-X-G motif; other site 452652002083 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 452652002084 ATP-grasp domain; Region: ATP-grasp_4; cl17255 452652002085 ATP-grasp domain; Region: ATP-grasp_4; cl17255 452652002086 AAA domain; Region: AAA_33; pfam13671 452652002087 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652002088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652002089 active site 452652002090 phosphorylation site [posttranslational modification] 452652002091 intermolecular recognition site; other site 452652002092 dimerization interface [polypeptide binding]; other site 452652002093 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652002094 DNA binding residues [nucleotide binding] 452652002095 dimerization interface [polypeptide binding]; other site 452652002096 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 452652002097 Histidine kinase; Region: HisKA_3; pfam07730 452652002098 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652002099 Mg2+ binding site [ion binding]; other site 452652002100 G-X-G motif; other site 452652002101 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 452652002102 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 452652002103 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 452652002104 Histidine kinase; Region: HisKA_3; pfam07730 452652002105 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652002106 ATP binding site [chemical binding]; other site 452652002107 Mg2+ binding site [ion binding]; other site 452652002108 G-X-G motif; other site 452652002109 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652002110 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652002111 active site 452652002112 phosphorylation site [posttranslational modification] 452652002113 intermolecular recognition site; other site 452652002114 dimerization interface [polypeptide binding]; other site 452652002115 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652002116 DNA binding residues [nucleotide binding] 452652002117 dimerization interface [polypeptide binding]; other site 452652002118 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 452652002119 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 452652002120 NodB motif; other site 452652002121 active site 452652002122 catalytic site [active] 452652002123 metal binding site [ion binding]; metal-binding site 452652002124 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 452652002125 Catalytic domain of Protein Kinases; Region: PKc; cd00180 452652002126 active site 452652002127 ATP binding site [chemical binding]; other site 452652002128 substrate binding site [chemical binding]; other site 452652002129 activation loop (A-loop); other site 452652002130 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 452652002131 Mechanosensitive ion channel; Region: MS_channel; pfam00924 452652002132 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 452652002133 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 452652002134 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 452652002135 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 452652002136 active site 452652002137 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652002138 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 452652002139 SnoaL-like domain; Region: SnoaL_2; pfam12680 452652002140 non-specific DNA binding site [nucleotide binding]; other site 452652002141 salt bridge; other site 452652002142 sequence-specific DNA binding site [nucleotide binding]; other site 452652002143 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 452652002144 trimer interface [polypeptide binding]; other site 452652002145 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cl00720 452652002146 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652002147 S-adenosylmethionine binding site [chemical binding]; other site 452652002148 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 452652002149 N-acetyl-D-glucosamine binding site [chemical binding]; other site 452652002150 catalytic residue [active] 452652002151 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 452652002152 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652002153 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 452652002154 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 452652002155 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 452652002156 anti sigma factor interaction site; other site 452652002157 regulatory phosphorylation site [posttranslational modification]; other site 452652002158 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 452652002159 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 452652002160 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 452652002161 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 452652002162 DNA photolyase; Region: DNA_photolyase; pfam00875 452652002163 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 452652002164 catalytic residue [active] 452652002165 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 452652002166 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 452652002167 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 452652002168 Ricin-type beta-trefoil; Region: RICIN; smart00458 452652002169 putative sugar binding sites [chemical binding]; other site 452652002170 Q-X-W motif; other site 452652002171 RNA polymerase sigma factor; Reviewed; Region: PRK12527 452652002172 Domain of unknown function (DUF3291); Region: DUF3291; pfam11695 452652002173 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 452652002174 putative DNA binding site [nucleotide binding]; other site 452652002175 dimerization interface [polypeptide binding]; other site 452652002176 Predicted transcriptional regulator [Transcription]; Region: COG2345 452652002177 putative Zn2+ binding site [ion binding]; other site 452652002178 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 452652002179 Double zinc ribbon; Region: DZR; pfam12773 452652002180 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 452652002181 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 452652002182 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 452652002183 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452652002184 Coenzyme A binding pocket [chemical binding]; other site 452652002185 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 452652002186 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 452652002187 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 452652002188 active site 452652002189 PHP-associated; Region: PHP_C; pfam13263 452652002190 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 452652002191 nudix motif; other site 452652002192 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 452652002193 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 452652002194 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 452652002195 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 452652002196 putative NAD(P) binding site [chemical binding]; other site 452652002197 putative active site [active] 452652002198 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 452652002199 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 452652002200 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 452652002201 Ligand Binding Site [chemical binding]; other site 452652002202 PAS domain; Region: PAS_9; pfam13426 452652002203 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 452652002204 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 452652002205 Predicted flavoprotein [General function prediction only]; Region: COG0431 452652002206 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 452652002207 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652002208 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652002209 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 452652002210 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 452652002211 Transcriptional regulators [Transcription]; Region: PurR; COG1609 452652002212 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 452652002213 DNA binding site [nucleotide binding] 452652002214 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 452652002215 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 452652002216 Transcriptional regulators [Transcription]; Region: GntR; COG1802 452652002217 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 452652002218 DNA-binding site [nucleotide binding]; DNA binding site 452652002219 FCD domain; Region: FCD; pfam07729 452652002220 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 452652002221 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 452652002222 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 452652002223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652002224 dimer interface [polypeptide binding]; other site 452652002225 conserved gate region; other site 452652002226 putative PBP binding loops; other site 452652002227 ABC-ATPase subunit interface; other site 452652002228 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 452652002229 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652002230 dimer interface [polypeptide binding]; other site 452652002231 conserved gate region; other site 452652002232 putative PBP binding loops; other site 452652002233 ABC-ATPase subunit interface; other site 452652002234 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 452652002235 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 452652002236 Walker A/P-loop; other site 452652002237 ATP binding site [chemical binding]; other site 452652002238 Q-loop/lid; other site 452652002239 ABC transporter signature motif; other site 452652002240 Walker B; other site 452652002241 D-loop; other site 452652002242 H-loop/switch region; other site 452652002243 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 452652002244 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 452652002245 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 452652002246 Walker A/P-loop; other site 452652002247 ATP binding site [chemical binding]; other site 452652002248 Q-loop/lid; other site 452652002249 ABC transporter signature motif; other site 452652002250 Walker B; other site 452652002251 D-loop; other site 452652002252 H-loop/switch region; other site 452652002253 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 452652002254 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 452652002255 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 452652002256 inhibitor site; inhibition site 452652002257 active site 452652002258 dimer interface [polypeptide binding]; other site 452652002259 catalytic residue [active] 452652002260 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 452652002261 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 452652002262 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 452652002263 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 452652002264 putative active site cavity [active] 452652002265 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 452652002266 catalytic site [active] 452652002267 BNR repeat-like domain; Region: BNR_2; pfam13088 452652002268 Asp-box motif; other site 452652002269 Transcriptional regulators [Transcription]; Region: FadR; COG2186 452652002270 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 452652002271 DNA-binding site [nucleotide binding]; DNA binding site 452652002272 FCD domain; Region: FCD; cl11656 452652002273 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652002274 putative substrate translocation pore; other site 452652002275 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 452652002276 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652002277 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 452652002278 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 452652002279 dimer interface [polypeptide binding]; other site 452652002280 ligand binding site [chemical binding]; other site 452652002281 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 452652002282 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 452652002283 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 452652002284 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452652002285 Coenzyme A binding pocket [chemical binding]; other site 452652002286 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 452652002287 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 452652002288 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 452652002289 Part of AAA domain; Region: AAA_19; pfam13245 452652002290 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 452652002291 AAA domain; Region: AAA_12; pfam13087 452652002292 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 452652002293 putative active site [active] 452652002294 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 452652002295 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652002296 Uncharacterized conserved protein [Function unknown]; Region: COG2353 452652002297 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 452652002298 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 452652002299 Walker A/P-loop; other site 452652002300 ATP binding site [chemical binding]; other site 452652002301 Q-loop/lid; other site 452652002302 ABC transporter signature motif; other site 452652002303 Walker B; other site 452652002304 D-loop; other site 452652002305 H-loop/switch region; other site 452652002306 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 452652002307 active site 452652002308 PBP superfamily domain; Region: PBP_like_2; cl17296 452652002309 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 452652002310 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652002311 dimer interface [polypeptide binding]; other site 452652002312 conserved gate region; other site 452652002313 putative PBP binding loops; other site 452652002314 ABC-ATPase subunit interface; other site 452652002315 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 452652002316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652002317 dimer interface [polypeptide binding]; other site 452652002318 conserved gate region; other site 452652002319 putative PBP binding loops; other site 452652002320 ABC-ATPase subunit interface; other site 452652002321 PBP superfamily domain; Region: PBP_like_2; cl17296 452652002322 PBP superfamily domain; Region: PBP_like_2; pfam12849 452652002323 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 452652002324 classical (c) SDRs; Region: SDR_c; cd05233 452652002325 NAD(P) binding site [chemical binding]; other site 452652002326 active site 452652002327 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 452652002328 Helix-turn-helix domain; Region: HTH_18; pfam12833 452652002329 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 452652002330 Flavoprotein; Region: Flavoprotein; pfam02441 452652002331 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 452652002332 Transcriptional regulators [Transcription]; Region: PurR; COG1609 452652002333 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 452652002334 DNA binding site [nucleotide binding] 452652002335 domain linker motif; other site 452652002336 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 452652002337 putative dimerization interface [polypeptide binding]; other site 452652002338 putative ligand binding site [chemical binding]; other site 452652002339 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 452652002340 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 452652002341 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 452652002342 nucleotide binding site [chemical binding]; other site 452652002343 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 452652002344 xylose isomerase; Provisional; Region: PRK12677 452652002345 Predicted nucleotidyltransferase [General function prediction only]; Region: COG1665 452652002346 Phosphotransferase enzyme family; Region: APH; pfam01636 452652002347 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 452652002348 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 452652002349 PLD-like domain; Region: PLDc_2; pfam13091 452652002350 catalytic site [active] 452652002351 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 452652002352 nudix motif; other site 452652002353 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 452652002354 Zn2+ binding site [ion binding]; other site 452652002355 Mg2+ binding site [ion binding]; other site 452652002356 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 452652002357 Histidine kinase; Region: HisKA_3; pfam07730 452652002358 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652002359 ATP binding site [chemical binding]; other site 452652002360 Mg2+ binding site [ion binding]; other site 452652002361 G-X-G motif; other site 452652002362 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652002363 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652002364 active site 452652002365 phosphorylation site [posttranslational modification] 452652002366 intermolecular recognition site; other site 452652002367 dimerization interface [polypeptide binding]; other site 452652002368 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652002369 DNA binding residues [nucleotide binding] 452652002370 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 452652002371 active site 452652002372 catalytic residues [active] 452652002373 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 452652002374 Catalytic domain of Protein Kinases; Region: PKc; cd00180 452652002375 active site 452652002376 substrate binding site [chemical binding]; other site 452652002377 ATP binding site [chemical binding]; other site 452652002378 activation loop (A-loop); other site 452652002379 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 452652002380 active site 452652002381 zinc binding site [ion binding]; other site 452652002382 amidase; Provisional; Region: PRK06170 452652002383 Amidase; Region: Amidase; cl11426 452652002384 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 452652002385 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 452652002386 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 452652002387 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652002388 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 452652002389 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 452652002390 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652002391 Walker A/P-loop; other site 452652002392 ATP binding site [chemical binding]; other site 452652002393 Q-loop/lid; other site 452652002394 ABC transporter signature motif; other site 452652002395 Walker B; other site 452652002396 D-loop; other site 452652002397 H-loop/switch region; other site 452652002398 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 452652002399 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652002400 Walker A/P-loop; other site 452652002401 ATP binding site [chemical binding]; other site 452652002402 Q-loop/lid; other site 452652002403 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652002404 D-loop; other site 452652002405 H-loop/switch region; other site 452652002406 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652002407 Walker A/P-loop; other site 452652002408 ATP binding site [chemical binding]; other site 452652002409 Q-loop/lid; other site 452652002410 ABC transporter signature motif; other site 452652002411 Walker B; other site 452652002412 D-loop; other site 452652002413 H-loop/switch region; other site 452652002414 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 452652002415 sugar binding site [chemical binding]; other site 452652002416 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 452652002417 sugar binding site [chemical binding]; other site 452652002418 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 452652002419 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 452652002420 TrkA-C domain; Region: TrkA_C; pfam02080 452652002421 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 452652002422 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 452652002423 Leucine carboxyl methyltransferase; Region: LCM; cl01306 452652002424 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 452652002425 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 452652002426 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 452652002427 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 452652002428 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 452652002429 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 452652002430 catalytic residues [active] 452652002431 dimer interface [polypeptide binding]; other site 452652002432 Isochorismatase family; Region: Isochorismatase; pfam00857 452652002433 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 452652002434 catalytic triad [active] 452652002435 conserved cis-peptide bond; other site 452652002436 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 452652002437 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 452652002438 putative metal binding site [ion binding]; other site 452652002439 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 452652002440 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 452652002441 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 452652002442 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 452652002443 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 452652002444 active site 452652002445 metal binding site [ion binding]; metal-binding site 452652002446 CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme; Region: GH25_CH-type; cd06412 452652002447 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 452652002448 active site 452652002449 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 452652002450 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 452652002451 active site 452652002452 substrate binding site [chemical binding]; other site 452652002453 cosubstrate binding site; other site 452652002454 catalytic site [active] 452652002455 Restriction endonuclease; Region: Mrr_cat; pfam04471 452652002456 Protein of unknown function (DUF664); Region: DUF664; pfam04978 452652002457 DinB superfamily; Region: DinB_2; pfam12867 452652002458 Protein of unknown function DUF89; Region: DUF89; pfam01937 452652002459 Tim44-like domain; Region: Tim44; cl09208 452652002460 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 452652002461 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 452652002462 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 452652002463 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652002464 S-adenosylmethionine binding site [chemical binding]; other site 452652002465 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 452652002466 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 452652002467 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 452652002468 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 452652002469 active site 452652002470 catalytic tetrad [active] 452652002471 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 452652002472 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 452652002473 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 452652002474 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 452652002475 active site 452652002476 catalytic triad [active] 452652002477 oxyanion hole [active] 452652002478 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 452652002479 Zn2+ binding site [ion binding]; other site 452652002480 Mg2+ binding site [ion binding]; other site 452652002481 Transcriptional regulators [Transcription]; Region: PurR; COG1609 452652002482 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 452652002483 DNA binding site [nucleotide binding] 452652002484 domain linker motif; other site 452652002485 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 452652002486 ligand binding site [chemical binding]; other site 452652002487 dimerization interface [polypeptide binding]; other site 452652002488 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 452652002489 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 452652002490 nucleotide binding site [chemical binding]; other site 452652002491 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 452652002492 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 452652002493 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12859 452652002494 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652002495 NAD(P) binding site [chemical binding]; other site 452652002496 active site 452652002497 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 452652002498 Cytochrome P450; Region: p450; cl12078 452652002499 Thioredoxin; Region: Thioredoxin_4; cl17273 452652002500 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 452652002501 putative active site [active] 452652002502 redox center [active] 452652002503 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652002504 NAD(P) binding site [chemical binding]; other site 452652002505 active site 452652002506 MarR family; Region: MarR_2; pfam12802 452652002507 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 452652002508 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 452652002509 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 452652002510 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 452652002511 active site 452652002512 NTP binding site [chemical binding]; other site 452652002513 metal binding triad [ion binding]; metal-binding site 452652002514 antibiotic binding site [chemical binding]; other site 452652002515 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 452652002516 Cellulose binding domain; Region: CBM_2; pfam00553 452652002517 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 452652002518 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452652002519 Coenzyme A binding pocket [chemical binding]; other site 452652002520 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452652002521 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 452652002522 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 452652002523 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 452652002524 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 452652002525 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 452652002526 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 452652002527 putative active site [active] 452652002528 catalytic triad [active] 452652002529 putative dimer interface [polypeptide binding]; other site 452652002530 Peptidase family M48; Region: Peptidase_M48; pfam01435 452652002531 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 452652002532 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 452652002533 active site 452652002534 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 452652002535 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 452652002536 putative DNA binding site [nucleotide binding]; other site 452652002537 putative Zn2+ binding site [ion binding]; other site 452652002538 AsnC family; Region: AsnC_trans_reg; pfam01037 452652002539 hypothetical protein; Provisional; Region: PRK06547 452652002540 stage V sporulation protein K; Region: spore_V_K; TIGR02881 452652002541 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452652002542 Walker A motif; other site 452652002543 ATP binding site [chemical binding]; other site 452652002544 Walker B motif; other site 452652002545 arginine finger; other site 452652002546 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 452652002547 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 452652002548 Domain of unknown function DUF21; Region: DUF21; pfam01595 452652002549 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 452652002550 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 452652002551 Domain of unknown function DUF21; Region: DUF21; pfam01595 452652002552 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 452652002553 Transporter associated domain; Region: CorC_HlyC; smart01091 452652002554 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 452652002555 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 452652002556 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 452652002557 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 452652002558 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 452652002559 metal binding site [ion binding]; metal-binding site 452652002560 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 452652002561 homopentamer interface [polypeptide binding]; other site 452652002562 active site 452652002563 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 452652002564 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 452652002565 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 452652002566 dimerization interface [polypeptide binding]; other site 452652002567 active site 452652002568 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 452652002569 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 452652002570 Lumazine binding domain; Region: Lum_binding; pfam00677 452652002571 Lumazine binding domain; Region: Lum_binding; pfam00677 452652002572 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 452652002573 ferredoxin-NADP+ reductase; Region: PLN02852 452652002574 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 452652002575 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 452652002576 Walker A/P-loop; other site 452652002577 ATP binding site [chemical binding]; other site 452652002578 Q-loop/lid; other site 452652002579 ABC transporter signature motif; other site 452652002580 Walker B; other site 452652002581 D-loop; other site 452652002582 H-loop/switch region; other site 452652002583 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452652002584 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 452652002585 FtsX-like permease family; Region: FtsX; pfam02687 452652002586 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 452652002587 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 452652002588 RHS Repeat; Region: RHS_repeat; pfam05593 452652002589 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 452652002590 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 452652002591 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 452652002592 Domain of unknown function DUF302; Region: DUF302; pfam03625 452652002593 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 452652002594 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 452652002595 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 452652002596 motif II; other site 452652002597 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 452652002598 Uncharacterized conserved protein [Function unknown]; Region: COG2135 452652002599 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 452652002600 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 452652002601 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 452652002602 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 452652002603 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 452652002604 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 452652002605 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 452652002606 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 452652002607 protein-splicing catalytic site; other site 452652002608 thioester formation/cholesterol transfer; other site 452652002609 Pretoxin HINT domain; Region: PT-HINT; pfam07591 452652002610 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 452652002611 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 452652002612 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 452652002613 intersubunit interface [polypeptide binding]; other site 452652002614 Carbohydrate binding domain; Region: CBM_25; smart01066 452652002615 Carbohydrate binding domain (family 25); Region: CBM_25; pfam03423 452652002616 Carbohydrate binding domain; Region: CBM_25; smart01066 452652002617 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 452652002618 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 452652002619 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 452652002620 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 452652002621 active site 452652002622 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 452652002623 active site 452652002624 catalytic site [active] 452652002625 catalytic site [active] 452652002626 Predicted transcriptional regulators [Transcription]; Region: COG1733 452652002627 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 452652002628 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652002629 NAD(P) binding site [chemical binding]; other site 452652002630 active site 452652002631 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 452652002632 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 452652002633 Aminoglycoside-2''-adenylyltransferase; Region: Aminoglyc_resit; pfam10706 452652002634 MarR family; Region: MarR_2; pfam12802 452652002635 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 452652002636 catalytic residue [active] 452652002637 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 452652002638 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 452652002639 NodB motif; other site 452652002640 active site 452652002641 catalytic site [active] 452652002642 metal binding site [ion binding]; metal-binding site 452652002643 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 452652002644 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452652002645 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 452652002646 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 452652002647 Low molecular weight phosphatase family; Region: LMWPc; cd00115 452652002648 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 452652002649 active site 452652002650 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 452652002651 putative DNA binding site [nucleotide binding]; other site 452652002652 dimerization interface [polypeptide binding]; other site 452652002653 putative Zn2+ binding site [ion binding]; other site 452652002654 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 452652002655 arsenical-resistance protein; Region: acr3; TIGR00832 452652002656 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 452652002657 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 452652002658 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 452652002659 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452652002660 Coenzyme A binding pocket [chemical binding]; other site 452652002661 Domain of unknown function (DUF397); Region: DUF397; pfam04149 452652002662 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 452652002663 dimerization interface [polypeptide binding]; other site 452652002664 putative DNA binding site [nucleotide binding]; other site 452652002665 putative Zn2+ binding site [ion binding]; other site 452652002666 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 452652002667 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 452652002668 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 452652002669 Interdomain contacts; other site 452652002670 Cytokine receptor motif; other site 452652002671 Cellulose binding domain; Region: CBM_2; pfam00553 452652002672 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 452652002673 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 452652002674 active site 452652002675 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652002676 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652002677 Uncharacterized conserved protein [Function unknown]; Region: COG5361 452652002678 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 452652002679 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 452652002680 NACHT domain; Region: NACHT; pfam05729 452652002681 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 452652002682 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 452652002683 active site 452652002684 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 452652002685 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 452652002686 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 452652002687 active site 452652002688 oxyanion hole [active] 452652002689 diaminopimelate decarboxylase; Region: lysA; TIGR01048 452652002690 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 452652002691 active site 452652002692 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 452652002693 substrate binding site [chemical binding]; other site 452652002694 catalytic residues [active] 452652002695 dimer interface [polypeptide binding]; other site 452652002696 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 452652002697 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 452652002698 DNA binding residues [nucleotide binding] 452652002699 putative dimer interface [polypeptide binding]; other site 452652002700 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 452652002701 catalytic triad [active] 452652002702 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 452652002703 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 452652002704 putative DNA binding site [nucleotide binding]; other site 452652002705 putative Zn2+ binding site [ion binding]; other site 452652002706 AsnC family; Region: AsnC_trans_reg; pfam01037 452652002707 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 452652002708 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 452652002709 active site 452652002710 Zn binding site [ion binding]; other site 452652002711 AAA domain; Region: AAA_17; pfam13207 452652002712 AAA domain; Region: AAA_18; pfam13238 452652002713 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652002714 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652002715 DNA binding residues [nucleotide binding] 452652002716 dimerization interface [polypeptide binding]; other site 452652002717 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 452652002718 ABC-2 type transporter; Region: ABC2_membrane; cl17235 452652002719 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652002720 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 452652002721 Walker A/P-loop; other site 452652002722 ATP binding site [chemical binding]; other site 452652002723 Q-loop/lid; other site 452652002724 ABC transporter signature motif; other site 452652002725 Walker B; other site 452652002726 D-loop; other site 452652002727 H-loop/switch region; other site 452652002728 Protein of unknown function (DUF1048); Region: DUF1048; cl01986 452652002729 Predicted transcriptional regulators [Transcription]; Region: COG1695 452652002730 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 452652002731 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652002732 non-specific DNA binding site [nucleotide binding]; other site 452652002733 salt bridge; other site 452652002734 sequence-specific DNA binding site [nucleotide binding]; other site 452652002735 Domain of unknown function (DUF397); Region: DUF397; pfam04149 452652002736 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652002737 S-adenosylmethionine binding site [chemical binding]; other site 452652002738 RES domain; Region: RES; pfam08808 452652002739 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 452652002740 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452652002741 Walker A motif; other site 452652002742 ATP binding site [chemical binding]; other site 452652002743 Walker B motif; other site 452652002744 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 452652002745 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 452652002746 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 452652002747 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 452652002748 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 452652002749 phosphopeptide binding site; other site 452652002750 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 452652002751 Catalytic domain of Protein Kinases; Region: PKc; cd00180 452652002752 active site 452652002753 ATP binding site [chemical binding]; other site 452652002754 substrate binding site [chemical binding]; other site 452652002755 activation loop (A-loop); other site 452652002756 CHAT domain; Region: CHAT; pfam12770 452652002757 EF-hand domain pair; Region: EF_hand_5; pfam13499 452652002758 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 452652002759 Ca2+ binding site [ion binding]; other site 452652002760 EF-hand domain pair; Region: EF_hand_5; pfam13499 452652002761 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 452652002762 Ca2+ binding site [ion binding]; other site 452652002763 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 452652002764 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 452652002765 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 452652002766 acyl-coenzyme A oxidase; Region: PLN02636 452652002767 active site 452652002768 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 452652002769 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 452652002770 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 452652002771 active site 452652002772 putative catalytic site [active] 452652002773 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 452652002774 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 452652002775 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 452652002776 ABC-ATPase subunit interface; other site 452652002777 dimer interface [polypeptide binding]; other site 452652002778 putative PBP binding regions; other site 452652002779 FecCD transport family; Region: FecCD; pfam01032 452652002780 dimer interface [polypeptide binding]; other site 452652002781 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 452652002782 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 452652002783 Walker A/P-loop; other site 452652002784 ATP binding site [chemical binding]; other site 452652002785 Q-loop/lid; other site 452652002786 ABC transporter signature motif; other site 452652002787 Walker B; other site 452652002788 D-loop; other site 452652002789 H-loop/switch region; other site 452652002790 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 452652002791 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 452652002792 siderophore binding site; other site 452652002793 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 452652002794 IucA / IucC family; Region: IucA_IucC; pfam04183 452652002795 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 452652002796 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652002797 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 452652002798 IucA / IucC family; Region: IucA_IucC; pfam04183 452652002799 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 452652002800 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 452652002801 dimer interface [polypeptide binding]; other site 452652002802 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 452652002803 active site 452652002804 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 452652002805 catalytic residues [active] 452652002806 substrate binding site [chemical binding]; other site 452652002807 Predicted flavoprotein [General function prediction only]; Region: COG0431 452652002808 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 452652002809 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 452652002810 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 452652002811 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 452652002812 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 452652002813 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 452652002814 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 452652002815 DXD motif; other site 452652002816 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 452652002817 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 452652002818 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 452652002819 DNA binding site [nucleotide binding] 452652002820 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 452652002821 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 452652002822 Domain of unknown function (DUF397); Region: DUF397; pfam04149 452652002823 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; cl17774 452652002824 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 452652002825 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 452652002826 substrate binding pocket [chemical binding]; other site 452652002827 membrane-bound complex binding site; other site 452652002828 hinge residues; other site 452652002829 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652002830 dimer interface [polypeptide binding]; other site 452652002831 conserved gate region; other site 452652002832 putative PBP binding loops; other site 452652002833 ABC-ATPase subunit interface; other site 452652002834 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 452652002835 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652002836 Walker A/P-loop; other site 452652002837 ATP binding site [chemical binding]; other site 452652002838 Q-loop/lid; other site 452652002839 ABC transporter signature motif; other site 452652002840 Walker B; other site 452652002841 D-loop; other site 452652002842 H-loop/switch region; other site 452652002843 methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188 452652002844 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652002845 S-adenosylmethionine binding site [chemical binding]; other site 452652002846 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 452652002847 PQQ-like domain; Region: PQQ_2; pfam13360 452652002848 Trp docking motif [polypeptide binding]; other site 452652002849 active site 452652002850 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 452652002851 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 452652002852 putative sugar binding sites [chemical binding]; other site 452652002853 Q-X-W motif; other site 452652002854 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 452652002855 HCO3- transporter family; Region: HCO3_cotransp; pfam00955 452652002856 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 452652002857 substrate binding pocket [chemical binding]; other site 452652002858 substrate-Mg2+ binding site; other site 452652002859 aspartate-rich region 1; other site 452652002860 aspartate-rich region 2; other site 452652002861 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 452652002862 EF-hand domain pair; Region: EF_hand_5; pfam13499 452652002863 Ca2+ binding site [ion binding]; other site 452652002864 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652002865 Methyltransferase domain; Region: Methyltransf_23; pfam13489 452652002866 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 452652002867 CHAP domain; Region: CHAP; pfam05257 452652002868 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452652002869 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 452652002870 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 452652002871 putative molybdopterin cofactor binding site [chemical binding]; other site 452652002872 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 452652002873 putative molybdopterin cofactor binding site; other site 452652002874 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 452652002875 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 452652002876 DNA binding site [nucleotide binding] 452652002877 Int/Topo IB signature motif; other site 452652002878 active site 452652002879 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 452652002880 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 452652002881 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 452652002882 protein-splicing catalytic site; other site 452652002883 thioester formation/cholesterol transfer; other site 452652002884 Pretoxin HINT domain; Region: PT-HINT; pfam07591 452652002885 SCP1.201-like deaminase; Region: SCP1201-deam; pfam14428 452652002886 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 452652002887 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 452652002888 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 452652002889 putative sugar binding sites [chemical binding]; other site 452652002890 Q-X-W motif; other site 452652002891 uracil-xanthine permease; Region: ncs2; TIGR00801 452652002892 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 452652002893 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 452652002894 DNA binding residues [nucleotide binding] 452652002895 putative dimer interface [polypeptide binding]; other site 452652002896 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 452652002897 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 452652002898 active site 452652002899 catalytic tetrad [active] 452652002900 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 452652002901 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 452652002902 Walker A/P-loop; other site 452652002903 ATP binding site [chemical binding]; other site 452652002904 Q-loop/lid; other site 452652002905 ABC transporter signature motif; other site 452652002906 Walker B; other site 452652002907 D-loop; other site 452652002908 H-loop/switch region; other site 452652002909 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 452652002910 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 452652002911 substrate binding pocket [chemical binding]; other site 452652002912 membrane-bound complex binding site; other site 452652002913 hinge residues; other site 452652002914 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 452652002915 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 452652002916 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 452652002917 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 452652002918 active site 452652002919 dimer interface [polypeptide binding]; other site 452652002920 non-prolyl cis peptide bond; other site 452652002921 insertion regions; other site 452652002922 Chitin binding domain; Region: Chitin_bind_3; pfam03067 452652002923 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 452652002924 aromatic chitin/cellulose binding site residues [chemical binding]; other site 452652002925 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 452652002926 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 452652002927 conserved cys residue [active] 452652002928 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 452652002929 Cytochrome P450; Region: p450; cl12078 452652002930 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 452652002931 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 452652002932 G2 box; other site 452652002933 Switch I region; other site 452652002934 G3 box; other site 452652002935 Switch II region; other site 452652002936 GTP/Mg2+ binding site [chemical binding]; other site 452652002937 G4 box; other site 452652002938 G5 box; other site 452652002939 Protein of unknown function (DUF742); Region: DUF742; pfam05331 452652002940 Roadblock/LC7 domain; Region: Robl_LC7; pfam03259 452652002941 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652002942 ATP binding site [chemical binding]; other site 452652002943 Mg2+ binding site [ion binding]; other site 452652002944 G-X-G motif; other site 452652002945 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 452652002946 catalytic residues [active] 452652002947 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 452652002948 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 452652002949 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652002950 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452652002951 DNA binding residues [nucleotide binding] 452652002952 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 452652002953 active site 452652002954 substrate binding sites [chemical binding]; other site 452652002955 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 452652002956 active site 452652002957 nucleotide binding site [chemical binding]; other site 452652002958 HIGH motif; other site 452652002959 KMSKS motif; other site 452652002960 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 452652002961 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 452652002962 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516 452652002963 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 452652002964 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 452652002965 active site 452652002966 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652002967 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652002968 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 452652002969 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 452652002970 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 452652002971 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 452652002972 tetramer interface [polypeptide binding]; other site 452652002973 active site 452652002974 Mg2+/Mn2+ binding site [ion binding]; other site 452652002975 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 452652002976 N-acetyl-D-glucosamine binding site [chemical binding]; other site 452652002977 catalytic residue [active] 452652002978 Membrane transport protein; Region: Mem_trans; cl09117 452652002979 Membrane transport protein; Region: Mem_trans; cl09117 452652002980 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652002981 NAD(P) binding site [chemical binding]; other site 452652002982 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652002983 active site 452652002984 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 452652002985 nudix motif; other site 452652002986 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 452652002987 nucleophile elbow; other site 452652002988 Methyltransferase domain; Region: Methyltransf_18; pfam12847 452652002989 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 452652002990 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 452652002991 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452652002992 Coenzyme A binding pocket [chemical binding]; other site 452652002993 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 452652002994 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 452652002995 NAD(P) binding site [chemical binding]; other site 452652002996 catalytic residues [active] 452652002997 choline dehydrogenase; Validated; Region: PRK02106 452652002998 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 452652002999 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 452652003000 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 452652003001 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 452652003002 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 452652003003 ligand binding site [chemical binding]; other site 452652003004 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 452652003005 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652003006 Walker A/P-loop; other site 452652003007 ATP binding site [chemical binding]; other site 452652003008 Q-loop/lid; other site 452652003009 ABC transporter signature motif; other site 452652003010 Walker B; other site 452652003011 D-loop; other site 452652003012 H-loop/switch region; other site 452652003013 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 452652003014 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 452652003015 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 452652003016 TM-ABC transporter signature motif; other site 452652003017 Pirin-related protein [General function prediction only]; Region: COG1741 452652003018 Pirin; Region: Pirin; pfam02678 452652003019 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 452652003020 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 452652003021 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 452652003022 substrate binding site [chemical binding]; other site 452652003023 hexamer interface [polypeptide binding]; other site 452652003024 metal binding site [ion binding]; metal-binding site 452652003025 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 452652003026 putative active site [active] 452652003027 Major Facilitator Superfamily; Region: MFS_1; pfam07690 452652003028 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 452652003029 Leucine rich repeat; Region: LRR_8; pfam13855 452652003030 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 452652003031 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 452652003032 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 452652003033 active site 452652003034 catalytic tetrad [active] 452652003035 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 452652003036 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 452652003037 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652003038 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 452652003039 Walker A/P-loop; other site 452652003040 ATP binding site [chemical binding]; other site 452652003041 Q-loop/lid; other site 452652003042 ABC transporter signature motif; other site 452652003043 Walker B; other site 452652003044 D-loop; other site 452652003045 H-loop/switch region; other site 452652003046 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652003047 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652003048 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 452652003049 16S rRNA methyltransferase B; Provisional; Region: PRK14902 452652003050 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 452652003051 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 452652003052 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 452652003053 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 452652003054 putative active site [active] 452652003055 substrate binding site [chemical binding]; other site 452652003056 putative cosubstrate binding site; other site 452652003057 catalytic site [active] 452652003058 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 452652003059 substrate binding site [chemical binding]; other site 452652003060 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 452652003061 active site 452652003062 catalytic residues [active] 452652003063 metal binding site [ion binding]; metal-binding site 452652003064 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 452652003065 primosome assembly protein PriA; Provisional; Region: PRK14873 452652003066 S-adenosylmethionine synthetase; Validated; Region: PRK05250 452652003067 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 452652003068 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 452652003069 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 452652003070 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 452652003071 Flavoprotein; Region: Flavoprotein; pfam02441 452652003072 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 452652003073 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 452652003074 Guanylate kinase; Region: Guanylate_kin; pfam00625 452652003075 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 452652003076 catalytic site [active] 452652003077 G-X2-G-X-G-K; other site 452652003078 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 452652003079 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 452652003080 active site 452652003081 dimer interface [polypeptide binding]; other site 452652003082 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 452652003083 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 452652003084 quinone interaction residues [chemical binding]; other site 452652003085 active site 452652003086 catalytic residues [active] 452652003087 FMN binding site [chemical binding]; other site 452652003088 substrate binding site [chemical binding]; other site 452652003089 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 452652003090 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 452652003091 ATP-grasp domain; Region: ATP-grasp_4; cl17255 452652003092 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 452652003093 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 452652003094 ATP-grasp domain; Region: ATP-grasp_4; cl17255 452652003095 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 452652003096 IMP binding site; other site 452652003097 dimer interface [polypeptide binding]; other site 452652003098 interdomain contacts; other site 452652003099 partial ornithine binding site; other site 452652003100 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 452652003101 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 452652003102 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 452652003103 catalytic site [active] 452652003104 subunit interface [polypeptide binding]; other site 452652003105 dihydroorotase; Validated; Region: pyrC; PRK09357 452652003106 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 452652003107 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 452652003108 active site 452652003109 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 452652003110 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 452652003111 active site 452652003112 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652003113 non-specific DNA binding site [nucleotide binding]; other site 452652003114 salt bridge; other site 452652003115 sequence-specific DNA binding site [nucleotide binding]; other site 452652003116 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 452652003117 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 452652003118 active site 2 [active] 452652003119 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 452652003120 putative RNA binding site [nucleotide binding]; other site 452652003121 elongation factor P; Validated; Region: PRK00529 452652003122 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 452652003123 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 452652003124 RNA binding site [nucleotide binding]; other site 452652003125 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 452652003126 RNA binding site [nucleotide binding]; other site 452652003127 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 452652003128 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 452652003129 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 452652003130 active site 452652003131 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 452652003132 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 452652003133 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 452652003134 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652003135 non-specific DNA binding site [nucleotide binding]; other site 452652003136 salt bridge; other site 452652003137 sequence-specific DNA binding site [nucleotide binding]; other site 452652003138 Cupin domain; Region: Cupin_2; pfam07883 452652003139 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 452652003140 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 452652003141 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 452652003142 putative DNA binding site [nucleotide binding]; other site 452652003143 catalytic residue [active] 452652003144 putative H2TH interface [polypeptide binding]; other site 452652003145 putative catalytic residues [active] 452652003146 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 452652003147 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 452652003148 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652003149 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652003150 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 452652003151 NAD(P) binding site [chemical binding]; other site 452652003152 active site 452652003153 AAA domain; Region: AAA_33; pfam13671 452652003154 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 452652003155 Dehydroquinase class II; Region: DHquinase_II; pfam01220 452652003156 trimer interface [polypeptide binding]; other site 452652003157 active site 452652003158 dimer interface [polypeptide binding]; other site 452652003159 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 452652003160 active site 452652003161 dimer interface [polypeptide binding]; other site 452652003162 metal binding site [ion binding]; metal-binding site 452652003163 shikimate kinase; Reviewed; Region: aroK; PRK00131 452652003164 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 452652003165 ADP binding site [chemical binding]; other site 452652003166 magnesium binding site [ion binding]; other site 452652003167 putative shikimate binding site; other site 452652003168 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 452652003169 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 452652003170 Tetramer interface [polypeptide binding]; other site 452652003171 active site 452652003172 FMN-binding site [chemical binding]; other site 452652003173 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 452652003174 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 452652003175 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 452652003176 shikimate binding site; other site 452652003177 NAD(P) binding site [chemical binding]; other site 452652003178 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 452652003179 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652003180 Walker A/P-loop; other site 452652003181 ATP binding site [chemical binding]; other site 452652003182 Q-loop/lid; other site 452652003183 ABC transporter signature motif; other site 452652003184 Walker B; other site 452652003185 D-loop; other site 452652003186 H-loop/switch region; other site 452652003187 YceG-like family; Region: YceG; pfam02618 452652003188 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 452652003189 dimerization interface [polypeptide binding]; other site 452652003190 YceG-like family; Region: YceG; pfam02618 452652003191 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 452652003192 dimerization interface [polypeptide binding]; other site 452652003193 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 452652003194 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 452652003195 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 452652003196 motif 1; other site 452652003197 active site 452652003198 motif 2; other site 452652003199 motif 3; other site 452652003200 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 452652003201 Predicted ATPase [General function prediction only]; Region: COG3903 452652003202 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 452652003203 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 452652003204 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 452652003205 RNA binding surface [nucleotide binding]; other site 452652003206 recombination factor protein RarA; Reviewed; Region: PRK13342 452652003207 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452652003208 Walker A motif; other site 452652003209 ATP binding site [chemical binding]; other site 452652003210 Walker B motif; other site 452652003211 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 452652003212 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 452652003213 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 452652003214 Transcriptional regulator [Transcription]; Region: LysR; COG0583 452652003215 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 452652003216 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 452652003217 dimerization interface [polypeptide binding]; other site 452652003218 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452652003219 Coenzyme A binding pocket [chemical binding]; other site 452652003220 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 452652003221 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 452652003222 dimer interface [polypeptide binding]; other site 452652003223 anticodon binding site; other site 452652003224 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 452652003225 homodimer interface [polypeptide binding]; other site 452652003226 motif 1; other site 452652003227 active site 452652003228 motif 2; other site 452652003229 GAD domain; Region: GAD; pfam02938 452652003230 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 452652003231 active site 452652003232 motif 3; other site 452652003233 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 452652003234 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 452652003235 dimer interface [polypeptide binding]; other site 452652003236 motif 1; other site 452652003237 active site 452652003238 motif 2; other site 452652003239 motif 3; other site 452652003240 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 452652003241 anticodon binding site; other site 452652003242 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 452652003243 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 452652003244 active site 452652003245 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 452652003246 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 452652003247 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 452652003248 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 452652003249 Zn2+ binding site [ion binding]; other site 452652003250 Mg2+ binding site [ion binding]; other site 452652003251 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 452652003252 synthetase active site [active] 452652003253 NTP binding site [chemical binding]; other site 452652003254 metal binding site [ion binding]; metal-binding site 452652003255 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 452652003256 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 452652003257 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 452652003258 active site 452652003259 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 452652003260 Protein export membrane protein; Region: SecD_SecF; pfam02355 452652003261 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 452652003262 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 452652003263 Preprotein translocase subunit; Region: YajC; pfam02699 452652003264 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 452652003265 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452652003266 Walker A motif; other site 452652003267 ATP binding site [chemical binding]; other site 452652003268 Walker B motif; other site 452652003269 arginine finger; other site 452652003270 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 452652003271 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 452652003272 RuvA N terminal domain; Region: RuvA_N; pfam01330 452652003273 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 452652003274 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 452652003275 active site 452652003276 putative DNA-binding cleft [nucleotide binding]; other site 452652003277 dimer interface [polypeptide binding]; other site 452652003278 hypothetical protein; Validated; Region: PRK00110 452652003279 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 452652003280 predicted active site [active] 452652003281 catalytic triad [active] 452652003282 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 452652003283 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 452652003284 active site 452652003285 multimer interface [polypeptide binding]; other site 452652003286 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cl01268 452652003287 putative substrate binding pocket [chemical binding]; other site 452652003288 trimer interface [polypeptide binding]; other site 452652003289 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 452652003290 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 452652003291 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 452652003292 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 452652003293 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 452652003294 putative acyl-acceptor binding pocket; other site 452652003295 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 452652003296 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 452652003297 elongation factor G; Reviewed; Region: PRK12740 452652003298 G1 box; other site 452652003299 GTP/Mg2+ binding site [chemical binding]; other site 452652003300 G2 box; other site 452652003301 Switch I region; other site 452652003302 G3 box; other site 452652003303 Switch II region; other site 452652003304 G4 box; other site 452652003305 G5 box; other site 452652003306 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 452652003307 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 452652003308 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 452652003309 Protein of unknown function, DUF393; Region: DUF393; pfam04134 452652003310 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 452652003311 nucleotide binding site/active site [active] 452652003312 HIT family signature motif; other site 452652003313 catalytic residue [active] 452652003314 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 452652003315 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 452652003316 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 452652003317 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 452652003318 active site 452652003319 dimer interface [polypeptide binding]; other site 452652003320 motif 1; other site 452652003321 motif 2; other site 452652003322 motif 3; other site 452652003323 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 452652003324 anticodon binding site; other site 452652003325 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 452652003326 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 452652003327 active site 452652003328 catalytic site [active] 452652003329 substrate binding site [chemical binding]; other site 452652003330 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 452652003331 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 452652003332 CGNR zinc finger; Region: zf-CGNR; pfam11706 452652003333 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 452652003334 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 452652003335 catalytic residues [active] 452652003336 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 452652003337 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 452652003338 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452652003339 Coenzyme A binding pocket [chemical binding]; other site 452652003340 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 452652003341 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 452652003342 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652003343 catalytic residue [active] 452652003344 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 452652003345 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 452652003346 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 452652003347 Catalytic domain of Protein Kinases; Region: PKc; cd00180 452652003348 active site 452652003349 ATP binding site [chemical binding]; other site 452652003350 substrate binding site [chemical binding]; other site 452652003351 activation loop (A-loop); other site 452652003352 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 452652003353 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 452652003354 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 452652003355 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 452652003356 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 452652003357 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 452652003358 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 452652003359 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 452652003360 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 452652003361 active site 452652003362 SAM binding site [chemical binding]; other site 452652003363 homodimer interface [polypeptide binding]; other site 452652003364 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 452652003365 putative FMN binding site [chemical binding]; other site 452652003366 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 452652003367 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 452652003368 putative dimer interface [polypeptide binding]; other site 452652003369 active site pocket [active] 452652003370 putative cataytic base [active] 452652003371 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 452652003372 active site 452652003373 SAM binding site [chemical binding]; other site 452652003374 putative homodimer interface [polypeptide binding]; other site 452652003375 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 452652003376 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 452652003377 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 452652003378 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 452652003379 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 452652003380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652003381 dimer interface [polypeptide binding]; other site 452652003382 conserved gate region; other site 452652003383 ABC-ATPase subunit interface; other site 452652003384 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 452652003385 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 452652003386 Walker A/P-loop; other site 452652003387 ATP binding site [chemical binding]; other site 452652003388 Q-loop/lid; other site 452652003389 ABC transporter signature motif; other site 452652003390 Walker B; other site 452652003391 D-loop; other site 452652003392 H-loop/switch region; other site 452652003393 NIL domain; Region: NIL; pfam09383 452652003394 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 452652003395 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 452652003396 FAD binding domain; Region: FAD_binding_4; pfam01565 452652003397 Berberine and berberine like; Region: BBE; pfam08031 452652003398 argininosuccinate lyase; Provisional; Region: PRK00855 452652003399 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 452652003400 active sites [active] 452652003401 tetramer interface [polypeptide binding]; other site 452652003402 argininosuccinate synthase; Provisional; Region: PRK13820 452652003403 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 452652003404 ANP binding site [chemical binding]; other site 452652003405 Substrate Binding Site II [chemical binding]; other site 452652003406 Substrate Binding Site I [chemical binding]; other site 452652003407 arginine repressor; Provisional; Region: PRK03341 452652003408 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 452652003409 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 452652003410 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 452652003411 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 452652003412 inhibitor-cofactor binding pocket; inhibition site 452652003413 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652003414 catalytic residue [active] 452652003415 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 452652003416 feedback inhibition sensing region; other site 452652003417 homohexameric interface [polypeptide binding]; other site 452652003418 nucleotide binding site [chemical binding]; other site 452652003419 N-acetyl-L-glutamate binding site [chemical binding]; other site 452652003420 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 452652003421 heterotetramer interface [polypeptide binding]; other site 452652003422 active site pocket [active] 452652003423 cleavage site 452652003424 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 452652003425 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 452652003426 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 452652003427 DNA binding site [nucleotide binding] 452652003428 Transcriptional regulators [Transcription]; Region: PurR; COG1609 452652003429 domain linker motif; other site 452652003430 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 452652003431 ligand binding site [chemical binding]; other site 452652003432 dimerization interface [polypeptide binding]; other site 452652003433 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 452652003434 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 452652003435 substrate binding site [chemical binding]; other site 452652003436 dimer interface [polypeptide binding]; other site 452652003437 ATP binding site [chemical binding]; other site 452652003438 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 452652003439 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 452652003440 active site 452652003441 non-prolyl cis peptide bond; other site 452652003442 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 452652003443 Riboflavin kinase; Region: Flavokinase; smart00904 452652003444 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 452652003445 Erythromycin esterase; Region: Erythro_esteras; pfam05139 452652003446 First Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt1; cd04772 452652003447 DNA binding residues [nucleotide binding] 452652003448 putative dimer interface [polypeptide binding]; other site 452652003449 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 452652003450 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 452652003451 DNA binding residues [nucleotide binding] 452652003452 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 452652003453 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 452652003454 active site 452652003455 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 452652003456 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652003457 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 452652003458 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 452652003459 dimer interface [polypeptide binding]; other site 452652003460 active site 452652003461 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 452652003462 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652003463 S-adenosylmethionine binding site [chemical binding]; other site 452652003464 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 452652003465 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 452652003466 DNA-binding site [nucleotide binding]; DNA binding site 452652003467 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 452652003468 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 452652003469 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652003470 homodimer interface [polypeptide binding]; other site 452652003471 catalytic residue [active] 452652003472 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 452652003473 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 452652003474 NodB motif; other site 452652003475 active site 452652003476 catalytic site [active] 452652003477 metal binding site [ion binding]; metal-binding site 452652003478 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 452652003479 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 452652003480 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 452652003481 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 452652003482 classical (c) SDRs; Region: SDR_c; cd05233 452652003483 NAD(P) binding site [chemical binding]; other site 452652003484 active site 452652003485 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 452652003486 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 452652003487 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 452652003488 Glycosyl hydrolase family 46 chitosanase domain. This family are composed of the chitosanase enzymes which hydrolyzes chitosan, a biopolymer of beta (1,4)-linked -D-glucosamine (GlcN) residues produced by partial or full deacetylation of chitin; Region: chitosanase_glyco_hydro_46; cd00978 452652003489 chitosan binding site [chemical binding]; other site 452652003490 catalytic residues [active] 452652003491 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 452652003492 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452652003493 Coenzyme A binding pocket [chemical binding]; other site 452652003494 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 452652003495 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 452652003496 putative tRNA-binding site [nucleotide binding]; other site 452652003497 B3/4 domain; Region: B3_4; pfam03483 452652003498 tRNA synthetase B5 domain; Region: B5; smart00874 452652003499 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 452652003500 dimer interface [polypeptide binding]; other site 452652003501 motif 1; other site 452652003502 motif 3; other site 452652003503 motif 2; other site 452652003504 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 452652003505 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 452652003506 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 452652003507 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 452652003508 dimer interface [polypeptide binding]; other site 452652003509 motif 1; other site 452652003510 active site 452652003511 motif 2; other site 452652003512 motif 3; other site 452652003513 PAS domain; Region: PAS; smart00091 452652003514 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 452652003515 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452652003516 dimer interface [polypeptide binding]; other site 452652003517 phosphorylation site [posttranslational modification] 452652003518 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652003519 ATP binding site [chemical binding]; other site 452652003520 Mg2+ binding site [ion binding]; other site 452652003521 G-X-G motif; other site 452652003522 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 452652003523 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 452652003524 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 452652003525 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 452652003526 23S rRNA binding site [nucleotide binding]; other site 452652003527 L21 binding site [polypeptide binding]; other site 452652003528 L13 binding site [polypeptide binding]; other site 452652003529 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 452652003530 translation initiation factor IF-3; Region: infC; TIGR00168 452652003531 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 452652003532 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 452652003533 glycine dehydrogenase; Provisional; Region: PRK05367 452652003534 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 452652003535 tetramer interface [polypeptide binding]; other site 452652003536 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652003537 catalytic residue [active] 452652003538 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 452652003539 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652003540 tetramer interface [polypeptide binding]; other site 452652003541 catalytic residue [active] 452652003542 PRC-barrel domain; Region: PRC; pfam05239 452652003543 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 452652003544 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652003545 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652003546 DNA polymerase IV; Provisional; Region: PRK03348 452652003547 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 452652003548 active site 452652003549 DNA binding site [nucleotide binding] 452652003550 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 452652003551 putative active site [active] 452652003552 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 452652003553 DNA binding residues [nucleotide binding] 452652003554 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 452652003555 Bifunctional nuclease; Region: DNase-RNase; pfam02577 452652003556 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 452652003557 DNA binding residues [nucleotide binding] 452652003558 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 452652003559 Double zinc ribbon; Region: DZR; pfam12773 452652003560 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 452652003561 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 452652003562 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 452652003563 phosphopeptide binding site; other site 452652003564 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 452652003565 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 452652003566 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 452652003567 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 452652003568 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 452652003569 active site 452652003570 Substrate binding site; other site 452652003571 Mg++ binding site; other site 452652003572 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 452652003573 putative trimer interface [polypeptide binding]; other site 452652003574 putative CoA binding site [chemical binding]; other site 452652003575 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 452652003576 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 452652003577 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 452652003578 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 452652003579 HPr interaction site; other site 452652003580 glycerol kinase (GK) interaction site [polypeptide binding]; other site 452652003581 active site 452652003582 phosphorylation site [posttranslational modification] 452652003583 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 452652003584 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 452652003585 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 452652003586 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 452652003587 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 452652003588 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 452652003589 acyl-activating enzyme (AAE) consensus motif; other site 452652003590 putative AMP binding site [chemical binding]; other site 452652003591 putative active site [active] 452652003592 putative CoA binding site [chemical binding]; other site 452652003593 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 452652003594 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 452652003595 nudix motif; other site 452652003596 UbiA prenyltransferase family; Region: UbiA; pfam01040 452652003597 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 452652003598 AMP-binding enzyme; Region: AMP-binding; pfam00501 452652003599 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452652003600 acyl-activating enzyme (AAE) consensus motif; other site 452652003601 AMP binding site [chemical binding]; other site 452652003602 active site 452652003603 CoA binding site [chemical binding]; other site 452652003604 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 452652003605 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 452652003606 hypothetical protein; Provisional; Region: PRK08317 452652003607 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652003608 S-adenosylmethionine binding site [chemical binding]; other site 452652003609 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 452652003610 CoA-transferase family III; Region: CoA_transf_3; pfam02515 452652003611 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452652003612 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 452652003613 acyl-activating enzyme (AAE) consensus motif; other site 452652003614 AMP binding site [chemical binding]; other site 452652003615 active site 452652003616 CoA binding site [chemical binding]; other site 452652003617 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 452652003618 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 452652003619 inhibitor-cofactor binding pocket; inhibition site 452652003620 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652003621 catalytic residue [active] 452652003622 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 452652003623 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 452652003624 inhibitor-cofactor binding pocket; inhibition site 452652003625 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652003626 catalytic residue [active] 452652003627 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 452652003628 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 452652003629 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 452652003630 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 452652003631 metal binding site [ion binding]; metal-binding site 452652003632 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 452652003633 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 452652003634 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 452652003635 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 452652003636 EF-hand domain pair; Region: EF_hand_5; pfam13499 452652003637 Ca2+ binding site [ion binding]; other site 452652003638 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 452652003639 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 452652003640 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137 452652003641 reactive center loop; other site 452652003642 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137 452652003643 reactive center loop; other site 452652003644 Transcriptional regulator [Transcription]; Region: IclR; COG1414 452652003645 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 452652003646 Bacterial transcriptional regulator; Region: IclR; pfam01614 452652003647 glycerol kinase; Provisional; Region: glpK; PRK00047 452652003648 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 452652003649 N- and C-terminal domain interface [polypeptide binding]; other site 452652003650 active site 452652003651 MgATP binding site [chemical binding]; other site 452652003652 catalytic site [active] 452652003653 metal binding site [ion binding]; metal-binding site 452652003654 putative homotetramer interface [polypeptide binding]; other site 452652003655 glycerol binding site [chemical binding]; other site 452652003656 homodimer interface [polypeptide binding]; other site 452652003657 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 452652003658 GntP family permease; Region: GntP_permease; pfam02447 452652003659 fructuronate transporter; Provisional; Region: PRK10034; cl15264 452652003660 Shikimate kinase; Region: SKI; pfam01202 452652003661 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 452652003662 ATP-binding site [chemical binding]; other site 452652003663 Transcriptional regulators [Transcription]; Region: FadR; COG2186 452652003664 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 452652003665 DNA-binding site [nucleotide binding]; DNA binding site 452652003666 FCD domain; Region: FCD; pfam07729 452652003667 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 452652003668 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452652003669 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 452652003670 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 452652003671 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 452652003672 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652003673 putative PBP binding loops; other site 452652003674 dimer interface [polypeptide binding]; other site 452652003675 ABC-ATPase subunit interface; other site 452652003676 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 452652003677 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652003678 dimer interface [polypeptide binding]; other site 452652003679 conserved gate region; other site 452652003680 putative PBP binding loops; other site 452652003681 ABC-ATPase subunit interface; other site 452652003682 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 452652003683 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 452652003684 Walker A/P-loop; other site 452652003685 ATP binding site [chemical binding]; other site 452652003686 Q-loop/lid; other site 452652003687 ABC transporter signature motif; other site 452652003688 Walker B; other site 452652003689 D-loop; other site 452652003690 H-loop/switch region; other site 452652003691 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 452652003692 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 452652003693 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 452652003694 Walker A/P-loop; other site 452652003695 ATP binding site [chemical binding]; other site 452652003696 Q-loop/lid; other site 452652003697 ABC transporter signature motif; other site 452652003698 Walker B; other site 452652003699 D-loop; other site 452652003700 H-loop/switch region; other site 452652003701 Peptidase_C39 like family; Region: DUF3335; pfam11814 452652003702 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 452652003703 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652003704 non-specific DNA binding site [nucleotide binding]; other site 452652003705 salt bridge; other site 452652003706 sequence-specific DNA binding site [nucleotide binding]; other site 452652003707 Cupin domain; Region: Cupin_2; pfam07883 452652003708 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 452652003709 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 452652003710 active site 452652003711 FMN binding site [chemical binding]; other site 452652003712 substrate binding site [chemical binding]; other site 452652003713 homotetramer interface [polypeptide binding]; other site 452652003714 catalytic residue [active] 452652003715 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 452652003716 putative DNA binding site [nucleotide binding]; other site 452652003717 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 452652003718 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 452652003719 DXD motif; other site 452652003720 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 452652003721 Streptomyces laminarinase-like, member of glycosyl hydrolase family 16; Region: GH16_Strep_laminarinase_like; cd02182 452652003722 active site 452652003723 catalytic residues [active] 452652003724 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 452652003725 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652003726 Major Facilitator Superfamily; Region: MFS_1; pfam07690 452652003727 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652003728 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 452652003729 MarR family; Region: MarR; pfam01047 452652003730 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 452652003731 putative active site [active] 452652003732 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 452652003733 ATP binding site [chemical binding]; other site 452652003734 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 452652003735 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 452652003736 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 452652003737 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 452652003738 methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188 452652003739 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652003740 S-adenosylmethionine binding site [chemical binding]; other site 452652003741 ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187 452652003742 putative ATP-grasp target RiPP; Region: GRASP_targ; TIGR04186 452652003743 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652003744 non-specific DNA binding site [nucleotide binding]; other site 452652003745 salt bridge; other site 452652003746 sequence-specific DNA binding site [nucleotide binding]; other site 452652003747 methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188 452652003748 Methyltransferase domain; Region: Methyltransf_18; pfam12847 452652003749 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 452652003750 nudix motif; other site 452652003751 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652003752 non-specific DNA binding site [nucleotide binding]; other site 452652003753 salt bridge; other site 452652003754 sequence-specific DNA binding site [nucleotide binding]; other site 452652003755 Phage terminase, small subunit; Region: Terminase_4; cl01525 452652003756 H+ Antiporter protein; Region: 2A0121; TIGR00900 452652003757 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 452652003758 Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606 452652003759 Phosphotransferase enzyme family; Region: APH; pfam01636 452652003760 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 452652003761 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 452652003762 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 452652003763 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 452652003764 Domain of unknown function (DUF397); Region: DUF397; pfam04149 452652003765 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652003766 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 452652003767 NAD(P) binding site [chemical binding]; other site 452652003768 active site 452652003769 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 452652003770 nudix motif; other site 452652003771 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 452652003772 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 452652003773 putative trimer interface [polypeptide binding]; other site 452652003774 putative CoA binding site [chemical binding]; other site 452652003775 Bacterial sugar transferase; Region: Bac_transf; pfam02397 452652003776 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 452652003777 putative ADP-binding pocket [chemical binding]; other site 452652003778 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 452652003779 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 452652003780 putative active site [active] 452652003781 putative metal binding site [ion binding]; other site 452652003782 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 452652003783 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 452652003784 putative active site [active] 452652003785 putative metal binding site [ion binding]; other site 452652003786 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 452652003787 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 452652003788 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652003789 putative substrate translocation pore; other site 452652003790 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 452652003791 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 452652003792 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 452652003793 active site 452652003794 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 452652003795 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 452652003796 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 452652003797 Walker A/P-loop; other site 452652003798 ATP binding site [chemical binding]; other site 452652003799 Q-loop/lid; other site 452652003800 ABC transporter signature motif; other site 452652003801 Walker B; other site 452652003802 D-loop; other site 452652003803 H-loop/switch region; other site 452652003804 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 452652003805 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 452652003806 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 452652003807 catalytic residues [active] 452652003808 hinge region; other site 452652003809 alpha helical domain; other site 452652003810 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 452652003811 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 452652003812 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 452652003813 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 452652003814 AAA domain; Region: AAA_31; pfam13614 452652003815 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 452652003816 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 452652003817 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 452652003818 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 452652003819 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 452652003820 inhibitor-cofactor binding pocket; inhibition site 452652003821 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652003822 catalytic residue [active] 452652003823 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 452652003824 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 452652003825 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 452652003826 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 452652003827 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 452652003828 MOSC domain; Region: MOSC; pfam03473 452652003829 Right handed beta helix region; Region: Beta_helix; pfam13229 452652003830 Right handed beta helix region; Region: Beta_helix; pfam13229 452652003831 Right handed beta helix region; Region: Beta_helix; pfam13229 452652003832 stage V sporulation protein K; Region: spore_V_K; TIGR02881 452652003833 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452652003834 Walker A motif; other site 452652003835 ATP binding site [chemical binding]; other site 452652003836 Walker B motif; other site 452652003837 arginine finger; other site 452652003838 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 452652003839 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 452652003840 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 452652003841 DNA binding residues [nucleotide binding] 452652003842 short chain dehydrogenase; Provisional; Region: PRK07041 452652003843 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 452652003844 putative NAD(P) binding site [chemical binding]; other site 452652003845 homodimer interface [polypeptide binding]; other site 452652003846 Transcriptional regulator [Transcription]; Region: LysR; COG0583 452652003847 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 452652003848 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 452652003849 dimerization interface [polypeptide binding]; other site 452652003850 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652003851 Domain of unknown function (DUF4267); Region: DUF4267; pfam14087 452652003852 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 452652003853 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 452652003854 catalytic residue [active] 452652003855 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 452652003856 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 452652003857 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 452652003858 Ligand binding site; other site 452652003859 Putative Catalytic site; other site 452652003860 DXD motif; other site 452652003861 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 452652003862 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 452652003863 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 452652003864 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 452652003865 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 452652003866 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 452652003867 active site 452652003868 Thymidylate kinase; Region: Thymidylate_kin; pfam02223 452652003869 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 452652003870 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 452652003871 metal binding site [ion binding]; metal-binding site 452652003872 dimer interface [polypeptide binding]; other site 452652003873 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652003874 non-specific DNA binding site [nucleotide binding]; other site 452652003875 salt bridge; other site 452652003876 sequence-specific DNA binding site [nucleotide binding]; other site 452652003877 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 452652003878 trimer interface [polypeptide binding]; other site 452652003879 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 452652003880 CoA binding site [chemical binding]; other site 452652003881 active site 452652003882 enoyl-CoA hydratase; Provisional; Region: PRK07827 452652003883 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 452652003884 substrate binding site [chemical binding]; other site 452652003885 oxyanion hole (OAH) forming residues; other site 452652003886 trimer interface [polypeptide binding]; other site 452652003887 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 452652003888 aromatic chitin/cellulose binding site residues [chemical binding]; other site 452652003889 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 452652003890 aromatic chitin/cellulose binding site residues [chemical binding]; other site 452652003891 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 452652003892 putative sugar binding site [chemical binding]; other site 452652003893 catalytic residues [active] 452652003894 N-acetyltransferase; Region: Acetyltransf_2; cl00949 452652003895 EamA-like transporter family; Region: EamA; pfam00892 452652003896 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 452652003897 EamA-like transporter family; Region: EamA; pfam00892 452652003898 tryptophan synthase subunit beta; Reviewed; Region: PRK12391 452652003899 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 452652003900 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 452652003901 catalytic residue [active] 452652003902 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 452652003903 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 452652003904 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 452652003905 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 452652003906 active site 452652003907 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 452652003908 pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099 452652003909 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 452652003910 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 452652003911 catalytic residue [active] 452652003912 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452652003913 AMP-binding enzyme; Region: AMP-binding; pfam00501 452652003914 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452652003915 acyl-activating enzyme (AAE) consensus motif; other site 452652003916 acyl-activating enzyme (AAE) consensus motif; other site 452652003917 AMP binding site [chemical binding]; other site 452652003918 active site 452652003919 CoA binding site [chemical binding]; other site 452652003920 CBD_II domain; Region: CBD_II; smart00637 452652003921 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 452652003922 Interdomain contacts; other site 452652003923 Cytokine receptor motif; other site 452652003924 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 452652003925 Glyco_18 domain; Region: Glyco_18; smart00636 452652003926 active site 452652003927 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 452652003928 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 452652003929 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 452652003930 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 452652003931 AAA domain; Region: AAA_33; pfam13671 452652003932 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 452652003933 nudix motif; other site 452652003934 acyl-CoA synthetase; Validated; Region: PRK07787 452652003935 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452652003936 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452652003937 acyl-activating enzyme (AAE) consensus motif; other site 452652003938 acyl-activating enzyme (AAE) consensus motif; other site 452652003939 AMP binding site [chemical binding]; other site 452652003940 active site 452652003941 CoA binding site [chemical binding]; other site 452652003942 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 452652003943 active site 452652003944 catalytic triad [active] 452652003945 calcium binding site [ion binding]; other site 452652003946 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 452652003947 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 452652003948 Ligand Binding Site [chemical binding]; other site 452652003949 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 452652003950 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 452652003951 Ligand binding site [chemical binding]; other site 452652003952 Electron transfer flavoprotein domain; Region: ETF; pfam01012 452652003953 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 452652003954 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 452652003955 catalytic residues [active] 452652003956 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 452652003957 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 452652003958 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 452652003959 putative acyl-acceptor binding pocket; other site 452652003960 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 452652003961 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 452652003962 active site 452652003963 Transcriptional regulators [Transcription]; Region: MarR; COG1846 452652003964 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 452652003965 putative DNA binding site [nucleotide binding]; other site 452652003966 putative Zn2+ binding site [ion binding]; other site 452652003967 Uncharacterized conserved protein [Function unknown]; Region: COG2128 452652003968 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 452652003969 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 452652003970 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 452652003971 tetramer interface [polypeptide binding]; other site 452652003972 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652003973 catalytic residue [active] 452652003974 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652003975 NAD(P) binding site [chemical binding]; other site 452652003976 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 452652003977 MarR family; Region: MarR; pfam01047 452652003978 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652003979 Major Facilitator Superfamily; Region: MFS_1; pfam07690 452652003980 putative substrate translocation pore; other site 452652003981 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652003982 Helix-turn-helix domain; Region: HTH_31; pfam13560 452652003983 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 452652003984 Domain of unknown function (DUF397); Region: DUF397; pfam04149 452652003985 G8 domain; Region: G8; pfam10162 452652003986 Right handed beta helix region; Region: Beta_helix; pfam13229 452652003987 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 452652003988 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 452652003989 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 452652003990 NlpC/P60 family; Region: NLPC_P60; pfam00877 452652003991 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 452652003992 acyl-activating enzyme (AAE) consensus motif; other site 452652003993 putative AMP binding site [chemical binding]; other site 452652003994 putative active site [active] 452652003995 putative CoA binding site [chemical binding]; other site 452652003996 Transcriptional regulators [Transcription]; Region: PurR; COG1609 452652003997 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 452652003998 DNA binding site [nucleotide binding] 452652003999 domain linker motif; other site 452652004000 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 452652004001 putative dimerization interface [polypeptide binding]; other site 452652004002 putative ligand binding site [chemical binding]; other site 452652004003 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 452652004004 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 452652004005 active site 452652004006 catalytic site [active] 452652004007 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 452652004008 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 452652004009 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652004010 dimer interface [polypeptide binding]; other site 452652004011 conserved gate region; other site 452652004012 putative PBP binding loops; other site 452652004013 ABC-ATPase subunit interface; other site 452652004014 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 452652004015 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652004016 dimer interface [polypeptide binding]; other site 452652004017 conserved gate region; other site 452652004018 putative PBP binding loops; other site 452652004019 ABC-ATPase subunit interface; other site 452652004020 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 452652004021 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 452652004022 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 452652004023 active site 452652004024 catalytic residues [active] 452652004025 AAA ATPase domain; Region: AAA_16; pfam13191 452652004026 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 452652004027 substrate binding pocket [chemical binding]; other site 452652004028 substrate-Mg2+ binding site; other site 452652004029 aspartate-rich region 1; other site 452652004030 aspartate-rich region 2; other site 452652004031 Short C-terminal domain; Region: SHOCT; pfam09851 452652004032 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 452652004033 Beta-lactamase; Region: Beta-lactamase; pfam00144 452652004034 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 452652004035 nudix motif; other site 452652004036 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652004037 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652004038 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 452652004039 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 452652004040 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 452652004041 Interdomain contacts; other site 452652004042 Cytokine receptor motif; other site 452652004043 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 452652004044 Glyco_18 domain; Region: Glyco_18; smart00636 452652004045 active site 452652004046 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 452652004047 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652004048 dimer interface [polypeptide binding]; other site 452652004049 conserved gate region; other site 452652004050 putative PBP binding loops; other site 452652004051 ABC-ATPase subunit interface; other site 452652004052 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652004053 dimer interface [polypeptide binding]; other site 452652004054 conserved gate region; other site 452652004055 putative PBP binding loops; other site 452652004056 ABC-ATPase subunit interface; other site 452652004057 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 452652004058 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 452652004059 substrate binding pocket [chemical binding]; other site 452652004060 membrane-bound complex binding site; other site 452652004061 hinge residues; other site 452652004062 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 452652004063 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 452652004064 Walker A/P-loop; other site 452652004065 ATP binding site [chemical binding]; other site 452652004066 Q-loop/lid; other site 452652004067 ABC transporter signature motif; other site 452652004068 Walker B; other site 452652004069 D-loop; other site 452652004070 H-loop/switch region; other site 452652004071 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 452652004072 substrate binding site [chemical binding]; other site 452652004073 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 452652004074 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 452652004075 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652004076 Walker A/P-loop; other site 452652004077 ATP binding site [chemical binding]; other site 452652004078 Q-loop/lid; other site 452652004079 ABC transporter signature motif; other site 452652004080 Walker B; other site 452652004081 D-loop; other site 452652004082 H-loop/switch region; other site 452652004083 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 452652004084 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652004085 Walker B; other site 452652004086 D-loop; other site 452652004087 H-loop/switch region; other site 452652004088 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 452652004089 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 452652004090 active site 452652004091 catalytic tetrad [active] 452652004092 Transcriptional regulators [Transcription]; Region: MarR; COG1846 452652004093 Transcriptional regulators [Transcription]; Region: MarR; COG1846 452652004094 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 452652004095 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652004096 NAD(P) binding site [chemical binding]; other site 452652004097 active site 452652004098 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 452652004099 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 452652004100 active site 452652004101 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 452652004102 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 452652004103 inhibitor-cofactor binding pocket; inhibition site 452652004104 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652004105 catalytic residue [active] 452652004106 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 452652004107 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 452652004108 TPP-binding site; other site 452652004109 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 452652004110 PYR/PP interface [polypeptide binding]; other site 452652004111 dimer interface [polypeptide binding]; other site 452652004112 TPP binding site [chemical binding]; other site 452652004113 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 452652004114 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 452652004115 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 452652004116 FeS/SAM binding site; other site 452652004117 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 452652004118 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 452652004119 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 452652004120 Active site cavity [active] 452652004121 catalytic acid [active] 452652004122 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 452652004123 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 452652004124 substrate binding pocket [chemical binding]; other site 452652004125 chain length determination region; other site 452652004126 substrate-Mg2+ binding site; other site 452652004127 catalytic residues [active] 452652004128 aspartate-rich region 1; other site 452652004129 active site lid residues [active] 452652004130 aspartate-rich region 2; other site 452652004131 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 452652004132 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 452652004133 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 452652004134 active site lid residues [active] 452652004135 substrate binding pocket [chemical binding]; other site 452652004136 catalytic residues [active] 452652004137 substrate-Mg2+ binding site; other site 452652004138 aspartate-rich region 1; other site 452652004139 aspartate-rich region 2; other site 452652004140 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 452652004141 active site lid residues [active] 452652004142 substrate binding pocket [chemical binding]; other site 452652004143 catalytic residues [active] 452652004144 substrate-Mg2+ binding site; other site 452652004145 aspartate-rich region 1; other site 452652004146 aspartate-rich region 2; other site 452652004147 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 452652004148 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 452652004149 Walker A/P-loop; other site 452652004150 ATP binding site [chemical binding]; other site 452652004151 Q-loop/lid; other site 452652004152 ABC transporter signature motif; other site 452652004153 Walker B; other site 452652004154 D-loop; other site 452652004155 H-loop/switch region; other site 452652004156 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 452652004157 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 452652004158 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 452652004159 active site 452652004160 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 452652004161 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 452652004162 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 452652004163 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 452652004164 active site 452652004165 NAD binding site [chemical binding]; other site 452652004166 metal binding site [ion binding]; metal-binding site 452652004167 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 452652004168 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 452652004169 active site 452652004170 metal-binding site 452652004171 isopentenyl-diphosphate delta-isomerase; Provisional; Region: PRK03759 452652004172 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 452652004173 nudix motif; other site 452652004174 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 452652004175 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652004176 ATP binding site [chemical binding]; other site 452652004177 Mg2+ binding site [ion binding]; other site 452652004178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652004179 Predicted ATPase [General function prediction only]; Region: COG3899 452652004180 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 452652004181 metal binding site 2 [ion binding]; metal-binding site 452652004182 putative DNA binding helix; other site 452652004183 metal binding site 1 [ion binding]; metal-binding site 452652004184 dimer interface [polypeptide binding]; other site 452652004185 structural Zn2+ binding site [ion binding]; other site 452652004186 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 452652004187 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 452652004188 dimer interface [polypeptide binding]; other site 452652004189 active site 452652004190 heme binding site [chemical binding]; other site 452652004191 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 452652004192 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 452652004193 Amidinotransferase; Region: Amidinotransf; pfam02274 452652004194 FAD binding domain; Region: FAD_binding_4; pfam01565 452652004195 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 452652004196 Berberine and berberine like; Region: BBE; pfam08031 452652004197 Cupin domain; Region: Cupin_2; pfam07883 452652004198 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652004199 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652004200 active site 452652004201 phosphorylation site [posttranslational modification] 452652004202 intermolecular recognition site; other site 452652004203 dimerization interface [polypeptide binding]; other site 452652004204 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652004205 DNA binding residues [nucleotide binding] 452652004206 dimerization interface [polypeptide binding]; other site 452652004207 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 452652004208 B12 binding site [chemical binding]; other site 452652004209 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 452652004210 Radical SAM superfamily; Region: Radical_SAM; pfam04055 452652004211 FeS/SAM binding site; other site 452652004212 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 452652004213 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 452652004214 active site 452652004215 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 452652004216 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 452652004217 active site 452652004218 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 452652004219 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 452652004220 Major Facilitator Superfamily; Region: MFS_1; pfam07690 452652004221 FAD dependent oxidoreductase; Region: DAO; pfam01266 452652004222 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 452652004223 tRNA synthetases class I (M); Region: tRNA-synt_1g; pfam09334 452652004224 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 452652004225 active site 452652004226 nucleotide binding site [chemical binding]; other site 452652004227 HIGH motif; other site 452652004228 KMSKS motif; other site 452652004229 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 452652004230 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 452652004231 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 452652004232 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 452652004233 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 452652004234 active site 452652004235 catalytic site [active] 452652004236 Major Facilitator Superfamily; Region: MFS_1; pfam07690 452652004237 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 452652004238 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 452652004239 domain interfaces; other site 452652004240 active site 452652004241 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 452652004242 Catalytic domain of Protein Kinases; Region: PKc; cd00180 452652004243 active site 452652004244 ATP binding site [chemical binding]; other site 452652004245 substrate binding site [chemical binding]; other site 452652004246 activation loop (A-loop); other site 452652004247 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 452652004248 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 452652004249 active site 452652004250 Phospholipid methyltransferase; Region: PEMT; cl17370 452652004251 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 452652004252 Cytochrome P450; Region: p450; cl12078 452652004253 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 452652004254 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 452652004255 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 452652004256 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 452652004257 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 452652004258 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 452652004259 substrate binding site; other site 452652004260 tetramer interface; other site 452652004261 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 452652004262 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 452652004263 NAD binding site [chemical binding]; other site 452652004264 substrate binding site [chemical binding]; other site 452652004265 homodimer interface [polypeptide binding]; other site 452652004266 active site 452652004267 Protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). The protein prenyltransferase family of lipid-modifying enzymes includes protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I...; Region: PTase; cd02890 452652004268 active site cavity [active] 452652004269 peptide binding pocket; other site 452652004270 lipid binding pocket [chemical binding]; lipid-binding site 452652004271 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 452652004272 heterodimer interface [polypeptide binding]; other site 452652004273 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 452652004274 Zn2+ binding site [ion binding]; other site 452652004275 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 452652004276 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652004277 putative substrate translocation pore; other site 452652004278 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 452652004279 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 452652004280 putative NAD(P) binding site [chemical binding]; other site 452652004281 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 452652004282 dimerization interface [polypeptide binding]; other site 452652004283 putative DNA binding site [nucleotide binding]; other site 452652004284 putative Zn2+ binding site [ion binding]; other site 452652004285 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 452652004286 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 452652004287 active site 452652004288 catalytic tetrad [active] 452652004289 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 452652004290 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 452652004291 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 452652004292 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 452652004293 tetramer interface [polypeptide binding]; other site 452652004294 heme binding pocket [chemical binding]; other site 452652004295 NADPH binding site [chemical binding]; other site 452652004296 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 452652004297 putative active site [active] 452652004298 putative substrate binding site [chemical binding]; other site 452652004299 ATP binding site [chemical binding]; other site 452652004300 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 452652004301 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 452652004302 active site 452652004303 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 452652004304 classical (c) SDRs; Region: SDR_c; cd05233 452652004305 NAD(P) binding site [chemical binding]; other site 452652004306 active site 452652004307 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652004308 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652004309 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 452652004310 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 452652004311 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 452652004312 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 452652004313 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 452652004314 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652004315 non-specific DNA binding site [nucleotide binding]; other site 452652004316 salt bridge; other site 452652004317 sequence-specific DNA binding site [nucleotide binding]; other site 452652004318 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 452652004319 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 452652004320 catalytic residues [active] 452652004321 catalytic nucleophile [active] 452652004322 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 452652004323 Putative zinc-finger; Region: zf-HC2; pfam13490 452652004324 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652004325 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452652004326 DNA binding residues [nucleotide binding] 452652004327 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 452652004328 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 452652004329 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 452652004330 catalytic residues [active] 452652004331 Fic family protein [Function unknown]; Region: COG3177 452652004332 Fic/DOC family; Region: Fic; pfam02661 452652004333 Pirin-related protein [General function prediction only]; Region: COG1741 452652004334 Pirin; Region: Pirin; pfam02678 452652004335 VPS10 domain; Region: VPS10; smart00602 452652004336 Transcriptional regulators [Transcription]; Region: MarR; COG1846 452652004337 MarR family; Region: MarR; pfam01047 452652004338 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 452652004339 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 452652004340 putative active site [active] 452652004341 metal binding site [ion binding]; metal-binding site 452652004342 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 452652004343 NADH(P)-binding; Region: NAD_binding_10; pfam13460 452652004344 NAD binding site [chemical binding]; other site 452652004345 substrate binding site [chemical binding]; other site 452652004346 putative active site [active] 452652004347 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 452652004348 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 452652004349 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 452652004350 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 452652004351 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 452652004352 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 452652004353 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 452652004354 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 452652004355 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 452652004356 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 452652004357 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 452652004358 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 452652004359 Walker A/P-loop; other site 452652004360 ATP binding site [chemical binding]; other site 452652004361 Q-loop/lid; other site 452652004362 ABC transporter signature motif; other site 452652004363 Walker B; other site 452652004364 D-loop; other site 452652004365 H-loop/switch region; other site 452652004366 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 452652004367 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 452652004368 Walker A/P-loop; other site 452652004369 ATP binding site [chemical binding]; other site 452652004370 Q-loop/lid; other site 452652004371 ABC transporter signature motif; other site 452652004372 Walker B; other site 452652004373 D-loop; other site 452652004374 H-loop/switch region; other site 452652004375 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 452652004376 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 452652004377 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 452652004378 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 452652004379 Sulfatase; Region: Sulfatase; pfam00884 452652004380 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167 452652004381 putative ligand binding site [chemical binding]; other site 452652004382 putative NAD binding site [chemical binding]; other site 452652004383 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 452652004384 catalytic site [active] 452652004385 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 452652004386 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 452652004387 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 452652004388 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 452652004389 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 452652004390 TIGR03084 family protein; Region: TIGR03084 452652004391 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 452652004392 Wyosine base formation; Region: Wyosine_form; pfam08608 452652004393 CHAT domain; Region: CHAT; pfam12770 452652004394 AAA ATPase domain; Region: AAA_16; pfam13191 452652004395 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452652004396 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452652004397 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452652004398 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452652004399 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452652004400 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452652004401 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 452652004402 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 452652004403 Multicopper oxidase; Region: Cu-oxidase; pfam00394 452652004404 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 452652004405 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652004406 non-specific DNA binding site [nucleotide binding]; other site 452652004407 salt bridge; other site 452652004408 sequence-specific DNA binding site [nucleotide binding]; other site 452652004409 Domain of unknown function (DUF397); Region: DUF397; pfam04149 452652004410 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 452652004411 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 452652004412 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 452652004413 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 452652004414 putative DNA binding site [nucleotide binding]; other site 452652004415 Uncharacterized conserved protein [Function unknown]; Region: COG1359 452652004416 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 452652004417 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652004418 Walker A/P-loop; other site 452652004419 ATP binding site [chemical binding]; other site 452652004420 Q-loop/lid; other site 452652004421 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 452652004422 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652004423 Walker A/P-loop; other site 452652004424 ATP binding site [chemical binding]; other site 452652004425 Q-loop/lid; other site 452652004426 ABC transporter signature motif; other site 452652004427 Walker B; other site 452652004428 D-loop; other site 452652004429 H-loop/switch region; other site 452652004430 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 452652004431 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 452652004432 DNA binding residues [nucleotide binding] 452652004433 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 452652004434 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 452652004435 NAD(P) binding site [chemical binding]; other site 452652004436 Protein of unknown function (DUF664); Region: DUF664; pfam04978 452652004437 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 452652004438 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 452652004439 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 452652004440 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 452652004441 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 452652004442 DNA binding residues [nucleotide binding] 452652004443 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 452652004444 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 452652004445 substrate binding site [chemical binding]; other site 452652004446 oxyanion hole (OAH) forming residues; other site 452652004447 trimer interface [polypeptide binding]; other site 452652004448 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 452652004449 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 452652004450 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 452652004451 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 452652004452 dimer interface [polypeptide binding]; other site 452652004453 active site 452652004454 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 452652004455 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 452652004456 active site 452652004457 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 452652004458 CoA-transferase family III; Region: CoA_transf_3; pfam02515 452652004459 Predicted acetyltransferase [General function prediction only]; Region: COG3393 452652004460 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 452652004461 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 452652004462 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 452652004463 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 452652004464 Transcriptional regulator [Transcription]; Region: IclR; COG1414 452652004465 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 452652004466 Bacterial transcriptional regulator; Region: IclR; pfam01614 452652004467 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 452652004468 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 452652004469 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652004470 dimer interface [polypeptide binding]; other site 452652004471 conserved gate region; other site 452652004472 putative PBP binding loops; other site 452652004473 ABC-ATPase subunit interface; other site 452652004474 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 452652004475 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652004476 dimer interface [polypeptide binding]; other site 452652004477 conserved gate region; other site 452652004478 putative PBP binding loops; other site 452652004479 ABC-ATPase subunit interface; other site 452652004480 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 452652004481 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 452652004482 hinge; other site 452652004483 active site 452652004484 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 452652004485 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652004486 Walker A/P-loop; other site 452652004487 ATP binding site [chemical binding]; other site 452652004488 Q-loop/lid; other site 452652004489 ABC transporter signature motif; other site 452652004490 Walker B; other site 452652004491 D-loop; other site 452652004492 H-loop/switch region; other site 452652004493 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 452652004494 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 452652004495 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652004496 Walker A/P-loop; other site 452652004497 ATP binding site [chemical binding]; other site 452652004498 Q-loop/lid; other site 452652004499 ABC transporter signature motif; other site 452652004500 Walker B; other site 452652004501 D-loop; other site 452652004502 H-loop/switch region; other site 452652004503 ABC transporter; Region: ABC_tran_2; pfam12848 452652004504 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 452652004505 Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney, using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers; Region: iodotyrosine_dehalogenase; cd02144 452652004506 putative FMN binding site [chemical binding]; other site 452652004507 putative dimer interface [polypeptide binding]; other site 452652004508 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 452652004509 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 452652004510 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652004511 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652004512 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 452652004513 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 452652004514 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 452652004515 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 452652004516 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 452652004517 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 452652004518 RNA binding site [nucleotide binding]; other site 452652004519 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 452652004520 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 452652004521 active site 452652004522 catalytic triad [active] 452652004523 oxyanion hole [active] 452652004524 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 452652004525 Cytochrome P450; Region: p450; cl12078 452652004526 Cytochrome P450; Region: p450; cl12078 452652004527 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 452652004528 Cytochrome P450; Region: p450; cl12078 452652004529 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 452652004530 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 452652004531 Transcriptional regulators [Transcription]; Region: MarR; COG1846 452652004532 MarR family; Region: MarR_2; pfam12802 452652004533 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 452652004534 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 452652004535 DNA binding residues [nucleotide binding] 452652004536 MMPL family; Region: MMPL; pfam03176 452652004537 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 452652004538 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 452652004539 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 452652004540 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652004541 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452652004542 DNA binding residues [nucleotide binding] 452652004543 Predicted transcriptional regulators [Transcription]; Region: COG1733 452652004544 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 452652004545 aminotransferase AlaT; Validated; Region: PRK09265 452652004546 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 452652004547 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652004548 homodimer interface [polypeptide binding]; other site 452652004549 catalytic residue [active] 452652004550 hypothetical protein; Provisional; Region: PRK02237 452652004551 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 452652004552 active site 452652004553 substrate binding site [chemical binding]; other site 452652004554 cosubstrate binding site; other site 452652004555 catalytic site [active] 452652004556 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 452652004557 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452652004558 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452652004559 Tetratricopeptide repeat; Region: TPR_10; pfam13374 452652004560 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 452652004561 active site 452652004562 metal binding site [ion binding]; metal-binding site 452652004563 hypothetical protein; Provisional; Region: PRK09266 452652004564 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 452652004565 homodimer interface [polypeptide binding]; other site 452652004566 substrate-cofactor binding pocket; other site 452652004567 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652004568 catalytic residue [active] 452652004569 Protein of unknown function (DUF664); Region: DUF664; pfam04978 452652004570 DinB superfamily; Region: DinB_2; pfam12867 452652004571 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 452652004572 FAD binding domain; Region: FAD_binding_2; pfam00890 452652004573 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 452652004574 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 452652004575 generic binding surface I; other site 452652004576 generic binding surface II; other site 452652004577 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 452652004578 putative active site [active] 452652004579 putative catalytic site [active] 452652004580 putative Mg binding site IVb [ion binding]; other site 452652004581 putative phosphate binding site [ion binding]; other site 452652004582 putative DNA binding site [nucleotide binding]; other site 452652004583 putative Mg binding site IVa [ion binding]; other site 452652004584 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 452652004585 Transcriptional regulator [Transcription]; Region: LysR; COG0583 452652004586 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 452652004587 LysR substrate binding domain; Region: LysR_substrate; pfam03466 452652004588 dimerization interface [polypeptide binding]; other site 452652004589 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 452652004590 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 452652004591 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 452652004592 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 452652004593 Interdomain contacts; other site 452652004594 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 452652004595 Glyco_18 domain; Region: Glyco_18; smart00636 452652004596 active site 452652004597 Predicted esterase [General function prediction only]; Region: COG0627 452652004598 S-formylglutathione hydrolase; Region: PLN02442 452652004599 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 452652004600 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 452652004601 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 452652004602 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 452652004603 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 452652004604 FeS/SAM binding site; other site 452652004605 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 452652004606 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 452652004607 metal-binding site 452652004608 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 452652004609 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 452652004610 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452652004611 PAS fold; Region: PAS_3; pfam08447 452652004612 putative active site [active] 452652004613 heme pocket [chemical binding]; other site 452652004614 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 452652004615 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 452652004616 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 452652004617 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 452652004618 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 452652004619 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 452652004620 bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192 452652004621 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cl00532 452652004622 alpha-gamma subunit interface [polypeptide binding]; other site 452652004623 beta-gamma subunit interface [polypeptide binding]; other site 452652004624 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cl00533 452652004625 alpha-beta subunit interface [polypeptide binding]; other site 452652004626 urease subunit alpha; Reviewed; Region: ureC; PRK13207 452652004627 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 452652004628 active site 452652004629 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 452652004630 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 452652004631 Cna protein B-type domain; Region: Cna_B; pfam05738 452652004632 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 452652004633 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 452652004634 DNA-binding site [nucleotide binding]; DNA binding site 452652004635 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 452652004636 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652004637 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 452652004638 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 452652004639 Domain of unknown function (DUF305); Region: DUF305; pfam03713 452652004640 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652004641 putative substrate translocation pore; other site 452652004642 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 452652004643 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 452652004644 putative Zn2+ binding site [ion binding]; other site 452652004645 putative DNA binding site [nucleotide binding]; other site 452652004646 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 452652004647 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 452652004648 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 452652004649 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 452652004650 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 452652004651 putative active site [active] 452652004652 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 452652004653 active site 452652004654 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 452652004655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652004656 dimer interface [polypeptide binding]; other site 452652004657 conserved gate region; other site 452652004658 putative PBP binding loops; other site 452652004659 ABC-ATPase subunit interface; other site 452652004660 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 452652004661 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 452652004662 Walker A/P-loop; other site 452652004663 ATP binding site [chemical binding]; other site 452652004664 Q-loop/lid; other site 452652004665 ABC transporter signature motif; other site 452652004666 Walker B; other site 452652004667 D-loop; other site 452652004668 H-loop/switch region; other site 452652004669 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 452652004670 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 452652004671 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 452652004672 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 452652004673 CysD dimerization site [polypeptide binding]; other site 452652004674 G1 box; other site 452652004675 putative GEF interaction site [polypeptide binding]; other site 452652004676 GTP/Mg2+ binding site [chemical binding]; other site 452652004677 Switch I region; other site 452652004678 G2 box; other site 452652004679 G3 box; other site 452652004680 Switch II region; other site 452652004681 G4 box; other site 452652004682 G5 box; other site 452652004683 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 452652004684 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 452652004685 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 452652004686 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 452652004687 Active Sites [active] 452652004688 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 452652004689 ligand-binding site [chemical binding]; other site 452652004690 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 452652004691 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 452652004692 Active Sites [active] 452652004693 60S ribosomal protein L37a; Provisional; Region: PTZ00255; cl00875 452652004694 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 452652004695 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 452652004696 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 452652004697 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 452652004698 GTPase RsgA; Reviewed; Region: PRK01889 452652004699 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 452652004700 GTPase/Zn-binding domain interface [polypeptide binding]; other site 452652004701 GTP/Mg2+ binding site [chemical binding]; other site 452652004702 G4 box; other site 452652004703 G5 box; other site 452652004704 G1 box; other site 452652004705 Switch I region; other site 452652004706 G2 box; other site 452652004707 G3 box; other site 452652004708 Switch II region; other site 452652004709 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 452652004710 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 452652004711 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452652004712 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 452652004713 endonuclease III; Region: ENDO3c; smart00478 452652004714 minor groove reading motif; other site 452652004715 helix-hairpin-helix signature motif; other site 452652004716 substrate binding pocket [chemical binding]; other site 452652004717 active site 452652004718 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 452652004719 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 452652004720 DNA binding site [nucleotide binding] 452652004721 active site 452652004722 MarR family; Region: MarR; pfam01047 452652004723 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 452652004724 DEAD-like helicases superfamily; Region: DEXDc; smart00487 452652004725 ATP binding site [chemical binding]; other site 452652004726 putative Mg++ binding site [ion binding]; other site 452652004727 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 452652004728 nucleotide binding region [chemical binding]; other site 452652004729 ATP-binding site [chemical binding]; other site 452652004730 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 452652004731 DNA-binding site [nucleotide binding]; DNA binding site 452652004732 RNA-binding motif; other site 452652004733 MMPL family; Region: MMPL; pfam03176 452652004734 MMPL family; Region: MMPL; pfam03176 452652004735 MMPL family; Region: MMPL; pfam03176 452652004736 Phosphotransferase enzyme family; Region: APH; pfam01636 452652004737 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 452652004738 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 452652004739 NodB motif; other site 452652004740 active site 452652004741 catalytic site [active] 452652004742 metal binding site [ion binding]; metal-binding site 452652004743 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 452652004744 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 452652004745 active site 452652004746 catalytic site [active] 452652004747 substrate binding site [chemical binding]; other site 452652004748 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 452652004749 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 452652004750 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 452652004751 active site 452652004752 catalytic site [active] 452652004753 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 452652004754 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 452652004755 NADP binding site [chemical binding]; other site 452652004756 active site 452652004757 steroid binding site; other site 452652004758 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 452652004759 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 452652004760 active site 452652004761 catalytic site [active] 452652004762 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 452652004763 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 452652004764 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 452652004765 catalytic site [active] 452652004766 active site 452652004767 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 452652004768 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 452652004769 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 452652004770 PYR/PP interface [polypeptide binding]; other site 452652004771 dimer interface [polypeptide binding]; other site 452652004772 TPP binding site [chemical binding]; other site 452652004773 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 452652004774 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 452652004775 TPP-binding site [chemical binding]; other site 452652004776 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 452652004777 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 452652004778 DNA binding residues [nucleotide binding] 452652004779 dimer interface [polypeptide binding]; other site 452652004780 [2Fe-2S] cluster binding site [ion binding]; other site 452652004781 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 452652004782 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652004783 S-adenosylmethionine binding site [chemical binding]; other site 452652004784 3-mercaptopyruvate sulfurtransferase; Region: PLN02723 452652004785 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 452652004786 active site residue [active] 452652004787 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 452652004788 active site residue [active] 452652004789 TIR domain; Region: TIR_2; pfam13676 452652004790 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652004791 non-specific DNA binding site [nucleotide binding]; other site 452652004792 salt bridge; other site 452652004793 sequence-specific DNA binding site [nucleotide binding]; other site 452652004794 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 452652004795 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 452652004796 CoA-binding site [chemical binding]; other site 452652004797 ATP-binding [chemical binding]; other site 452652004798 Uncharacterized conserved protein [Function unknown]; Region: COG3379 452652004799 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 452652004800 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 452652004801 MMPL family; Region: MMPL; pfam03176 452652004802 MMPL family; Region: MMPL; pfam03176 452652004803 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 452652004804 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 452652004805 RNA binding site [nucleotide binding]; other site 452652004806 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 452652004807 RNA binding site [nucleotide binding]; other site 452652004808 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 452652004809 RNA binding site [nucleotide binding]; other site 452652004810 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 452652004811 RNA binding site [nucleotide binding]; other site 452652004812 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652004813 S-adenosylmethionine binding site [chemical binding]; other site 452652004814 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 452652004815 nucleotide binding region [chemical binding]; other site 452652004816 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 452652004817 ATP-binding site [chemical binding]; other site 452652004818 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 452652004819 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 452652004820 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 452652004821 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 452652004822 DNA polymerase I; Provisional; Region: PRK05755 452652004823 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 452652004824 active site 452652004825 metal binding site 1 [ion binding]; metal-binding site 452652004826 putative 5' ssDNA interaction site; other site 452652004827 metal binding site 3; metal-binding site 452652004828 metal binding site 2 [ion binding]; metal-binding site 452652004829 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 452652004830 putative DNA binding site [nucleotide binding]; other site 452652004831 putative metal binding site [ion binding]; other site 452652004832 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 452652004833 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 452652004834 active site 452652004835 DNA binding site [nucleotide binding] 452652004836 catalytic site [active] 452652004837 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 452652004838 CoenzymeA binding site [chemical binding]; other site 452652004839 subunit interaction site [polypeptide binding]; other site 452652004840 PHB binding site; other site 452652004841 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 452652004842 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 452652004843 dimerization interface [polypeptide binding]; other site 452652004844 ligand binding site [chemical binding]; other site 452652004845 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 452652004846 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 452652004847 TM-ABC transporter signature motif; other site 452652004848 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 452652004849 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 452652004850 TM-ABC transporter signature motif; other site 452652004851 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 452652004852 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 452652004853 Walker A/P-loop; other site 452652004854 ATP binding site [chemical binding]; other site 452652004855 Q-loop/lid; other site 452652004856 ABC transporter signature motif; other site 452652004857 Walker B; other site 452652004858 D-loop; other site 452652004859 H-loop/switch region; other site 452652004860 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 452652004861 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 452652004862 Walker A/P-loop; other site 452652004863 ATP binding site [chemical binding]; other site 452652004864 Q-loop/lid; other site 452652004865 ABC transporter signature motif; other site 452652004866 Walker B; other site 452652004867 D-loop; other site 452652004868 H-loop/switch region; other site 452652004869 Response regulator receiver domain; Region: Response_reg; pfam00072 452652004870 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652004871 active site 452652004872 phosphorylation site [posttranslational modification] 452652004873 intermolecular recognition site; other site 452652004874 dimerization interface [polypeptide binding]; other site 452652004875 ANTAR domain; Region: ANTAR; pfam03861 452652004876 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 452652004877 pyruvate kinase; Provisional; Region: PRK06247 452652004878 domain interfaces; other site 452652004879 active site 452652004880 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 452652004881 2',3'-cyclic-nucleotide 2'-phosphodiesterase; Region: CycNucDiestase; TIGR01390 452652004882 active site 452652004883 metal binding site [ion binding]; metal-binding site 452652004884 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 452652004885 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 452652004886 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452652004887 Coenzyme A binding pocket [chemical binding]; other site 452652004888 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 452652004889 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 452652004890 NAD(P) binding site [chemical binding]; other site 452652004891 catalytic residues [active] 452652004892 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652004893 non-specific DNA binding site [nucleotide binding]; other site 452652004894 salt bridge; other site 452652004895 sequence-specific DNA binding site [nucleotide binding]; other site 452652004896 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 452652004897 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 452652004898 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 452652004899 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 452652004900 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 452652004901 active site 452652004902 dimer interface [polypeptide binding]; other site 452652004903 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 452652004904 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 452652004905 active site 452652004906 FMN binding site [chemical binding]; other site 452652004907 substrate binding site [chemical binding]; other site 452652004908 3Fe-4S cluster binding site [ion binding]; other site 452652004909 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 452652004910 domain interface; other site 452652004911 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 452652004912 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 452652004913 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 452652004914 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 452652004915 catalytic residues [active] 452652004916 Methylamine utilisation protein MauE; Region: MauE; pfam07291 452652004917 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 452652004918 substrate binding site [chemical binding]; other site 452652004919 active site 452652004920 catalytic residues [active] 452652004921 heterodimer interface [polypeptide binding]; other site 452652004922 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 452652004923 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 452652004924 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652004925 catalytic residue [active] 452652004926 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 452652004927 active site 452652004928 ribulose/triose binding site [chemical binding]; other site 452652004929 phosphate binding site [ion binding]; other site 452652004930 substrate (anthranilate) binding pocket [chemical binding]; other site 452652004931 product (indole) binding pocket [chemical binding]; other site 452652004932 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 452652004933 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; cl17850 452652004934 anthranilate synthase component I; Provisional; Region: PRK13571 452652004935 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 452652004936 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 452652004937 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 452652004938 Septum formation; Region: Septum_form; pfam13845 452652004939 TIGR03085 family protein; Region: TIGR03085 452652004940 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 452652004941 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 452652004942 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 452652004943 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 452652004944 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 452652004945 substrate binding site [chemical binding]; other site 452652004946 glutamase interaction surface [polypeptide binding]; other site 452652004947 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 452652004948 homotrimer interaction site [polypeptide binding]; other site 452652004949 putative active site [active] 452652004950 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 452652004951 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 452652004952 catalytic residues [active] 452652004953 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 452652004954 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 452652004955 putative active site [active] 452652004956 oxyanion strand; other site 452652004957 catalytic triad [active] 452652004958 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 452652004959 putative active site pocket [active] 452652004960 4-fold oligomerization interface [polypeptide binding]; other site 452652004961 metal binding residues [ion binding]; metal-binding site 452652004962 3-fold/trimer interface [polypeptide binding]; other site 452652004963 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 452652004964 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 452652004965 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652004966 homodimer interface [polypeptide binding]; other site 452652004967 catalytic residue [active] 452652004968 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 452652004969 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 452652004970 NAD binding site [chemical binding]; other site 452652004971 dimerization interface [polypeptide binding]; other site 452652004972 product binding site; other site 452652004973 substrate binding site [chemical binding]; other site 452652004974 zinc binding site [ion binding]; other site 452652004975 catalytic residues [active] 452652004976 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 452652004977 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 452652004978 putative deacylase active site [active] 452652004979 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 452652004980 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652004981 Walker A/P-loop; other site 452652004982 ATP binding site [chemical binding]; other site 452652004983 Q-loop/lid; other site 452652004984 ABC transporter signature motif; other site 452652004985 Walker B; other site 452652004986 D-loop; other site 452652004987 H-loop/switch region; other site 452652004988 LabA_like proteins; Region: LabA_like; cd06167 452652004989 Uncharacterized conserved protein [Function unknown]; Region: COG1432 452652004990 putative metal binding site [ion binding]; other site 452652004991 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 452652004992 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 452652004993 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 452652004994 Class I aldolases; Region: Aldolase_Class_I; cl17187 452652004995 catalytic residue [active] 452652004996 Transcriptional regulator [Transcription]; Region: LysR; COG0583 452652004997 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 452652004998 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 452652004999 putative dimerization interface [polypeptide binding]; other site 452652005000 PemK-like protein; Region: PemK; pfam02452 452652005001 RDD family; Region: RDD; pfam06271 452652005002 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 452652005003 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 452652005004 active site 452652005005 PHP Thumb interface [polypeptide binding]; other site 452652005006 metal binding site [ion binding]; metal-binding site 452652005007 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 452652005008 generic binding surface I; other site 452652005009 generic binding surface II; other site 452652005010 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 452652005011 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 452652005012 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 452652005013 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 452652005014 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 452652005015 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 452652005016 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 452652005017 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 452652005018 active site 452652005019 Substrate binding site; other site 452652005020 Mg++ binding site; other site 452652005021 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 452652005022 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 452652005023 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 452652005024 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 452652005025 active site 452652005026 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 452652005027 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 452652005028 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 452652005029 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 452652005030 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 452652005031 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 452652005032 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 452652005033 catalytic residue [active] 452652005034 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 452652005035 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 452652005036 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452652005037 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 452652005038 acyl-activating enzyme (AAE) consensus motif; other site 452652005039 AMP binding site [chemical binding]; other site 452652005040 active site 452652005041 CoA binding site [chemical binding]; other site 452652005042 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 452652005043 Helix-turn-helix domain; Region: HTH_17; pfam12728 452652005044 RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248 452652005045 ATP binding site [chemical binding]; other site 452652005046 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 452652005047 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 452652005048 active site 452652005049 ATP binding site [chemical binding]; other site 452652005050 substrate binding site [chemical binding]; other site 452652005051 activation loop (A-loop); other site 452652005052 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 452652005053 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 452652005054 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 452652005055 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652005056 Walker A/P-loop; other site 452652005057 ATP binding site [chemical binding]; other site 452652005058 Q-loop/lid; other site 452652005059 ABC transporter signature motif; other site 452652005060 Walker B; other site 452652005061 D-loop; other site 452652005062 H-loop/switch region; other site 452652005063 Mechanosensitive ion channel; Region: MS_channel; pfam00924 452652005064 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 452652005065 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 452652005066 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 452652005067 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 452652005068 RNA binding surface [nucleotide binding]; other site 452652005069 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 452652005070 active site 452652005071 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 452652005072 active site 452652005073 FMN binding site [chemical binding]; other site 452652005074 substrate binding site [chemical binding]; other site 452652005075 3Fe-4S cluster binding site [ion binding]; other site 452652005076 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 452652005077 lipoprotein signal peptidase; Provisional; Region: PRK14764 452652005078 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 452652005079 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 452652005080 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 452652005081 HIGH motif; other site 452652005082 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 452652005083 active site 452652005084 KMSKS motif; other site 452652005085 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 452652005086 tRNA binding surface [nucleotide binding]; other site 452652005087 anticodon binding site; other site 452652005088 DivIVA protein; Region: DivIVA; pfam05103 452652005089 DivIVA domain; Region: DivI1A_domain; TIGR03544 452652005090 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 452652005091 Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390 452652005092 YGGT family; Region: YGGT; pfam02325 452652005093 Protein of unknown function (DUF552); Region: DUF552; pfam04472 452652005094 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 452652005095 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 452652005096 catalytic residue [active] 452652005097 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 452652005098 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 452652005099 cell division protein FtsZ; Validated; Region: PRK09330 452652005100 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 452652005101 nucleotide binding site [chemical binding]; other site 452652005102 SulA interaction site; other site 452652005103 cell division protein FtsQ; Provisional; Region: PRK05529 452652005104 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 452652005105 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 452652005106 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 452652005107 active site 452652005108 homodimer interface [polypeptide binding]; other site 452652005109 cell division protein FtsW; Region: ftsW; TIGR02614 452652005110 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 452652005111 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 452652005112 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 452652005113 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 452652005114 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 452652005115 Mg++ binding site [ion binding]; other site 452652005116 putative catalytic motif [active] 452652005117 putative substrate binding site [chemical binding]; other site 452652005118 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 452652005119 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 452652005120 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 452652005121 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 452652005122 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 452652005123 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 452652005124 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 452652005125 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 452652005126 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 452652005127 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 452652005128 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 452652005129 MraW methylase family; Region: Methyltransf_5; cl17771 452652005130 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 452652005131 active site clefts [active] 452652005132 zinc binding site [ion binding]; other site 452652005133 dimer interface [polypeptide binding]; other site 452652005134 MoxR-like ATPases [General function prediction only]; Region: COG0714 452652005135 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452652005136 Walker A motif; other site 452652005137 ATP binding site [chemical binding]; other site 452652005138 Walker B motif; other site 452652005139 arginine finger; other site 452652005140 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 452652005141 Protein of unknown function DUF58; Region: DUF58; pfam01882 452652005142 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 452652005143 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 452652005144 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 452652005145 Methyltransferase domain; Region: Methyltransf_23; pfam13489 452652005146 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652005147 S-adenosylmethionine binding site [chemical binding]; other site 452652005148 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 452652005149 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 452652005150 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 452652005151 FAD binding site [chemical binding]; other site 452652005152 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 452652005153 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 452652005154 substrate binding pocket [chemical binding]; other site 452652005155 chain length determination region; other site 452652005156 substrate-Mg2+ binding site; other site 452652005157 catalytic residues [active] 452652005158 aspartate-rich region 1; other site 452652005159 active site lid residues [active] 452652005160 aspartate-rich region 2; other site 452652005161 VanZ like family; Region: VanZ; pfam04892 452652005162 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 452652005163 thiamine phosphate binding site [chemical binding]; other site 452652005164 active site 452652005165 pyrophosphate binding site [ion binding]; other site 452652005166 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 452652005167 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 452652005168 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 452652005169 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 452652005170 thiS-thiF/thiG interaction site; other site 452652005171 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 452652005172 ThiS interaction site; other site 452652005173 putative active site [active] 452652005174 tetramer interface [polypeptide binding]; other site 452652005175 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 452652005176 Catalytic domain of Protein Kinases; Region: PKc; cd00180 452652005177 active site 452652005178 ATP binding site [chemical binding]; other site 452652005179 substrate binding site [chemical binding]; other site 452652005180 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 452652005181 substrate binding site [chemical binding]; other site 452652005182 activation loop (A-loop); other site 452652005183 activation loop (A-loop); other site 452652005184 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 452652005185 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 452652005186 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 452652005187 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 452652005188 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 452652005189 Moco binding site; other site 452652005190 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 452652005191 metal coordination site [ion binding]; other site 452652005192 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 452652005193 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 452652005194 heme binding site [chemical binding]; other site 452652005195 ferroxidase pore; other site 452652005196 ferroxidase diiron center [ion binding]; other site 452652005197 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 452652005198 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 452652005199 chorismate binding enzyme; Region: Chorismate_bind; cl10555 452652005200 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 452652005201 Glutamine amidotransferase class-I; Region: GATase; pfam00117 452652005202 glutamine binding [chemical binding]; other site 452652005203 catalytic triad [active] 452652005204 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652005205 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652005206 active site 452652005207 phosphorylation site [posttranslational modification] 452652005208 intermolecular recognition site; other site 452652005209 dimerization interface [polypeptide binding]; other site 452652005210 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652005211 DNA binding residues [nucleotide binding] 452652005212 dimerization interface [polypeptide binding]; other site 452652005213 Histidine kinase; Region: HisKA_3; pfam07730 452652005214 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652005215 ATP binding site [chemical binding]; other site 452652005216 Mg2+ binding site [ion binding]; other site 452652005217 G-X-G motif; other site 452652005218 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 452652005219 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 452652005220 putative acyl-acceptor binding pocket; other site 452652005221 Esterase/lipase [General function prediction only]; Region: COG1647 452652005222 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 452652005223 putative catalytic site [active] 452652005224 putative metal binding site [ion binding]; other site 452652005225 putative catalytic site [active] 452652005226 putative phosphate binding site [ion binding]; other site 452652005227 putative phosphate binding site [ion binding]; other site 452652005228 putative metal binding site [ion binding]; other site 452652005229 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 452652005230 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 452652005231 nucleotide binding site [chemical binding]; other site 452652005232 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 452652005233 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 452652005234 putative hydrophobic ligand binding site [chemical binding]; other site 452652005235 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 452652005236 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 452652005237 acyl-activating enzyme (AAE) consensus motif; other site 452652005238 putative AMP binding site [chemical binding]; other site 452652005239 putative active site [active] 452652005240 putative CoA binding site [chemical binding]; other site 452652005241 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 452652005242 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 452652005243 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 452652005244 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 452652005245 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 452652005246 ATP binding site [chemical binding]; other site 452652005247 substrate binding site [chemical binding]; other site 452652005248 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 452652005249 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 452652005250 NlpC/P60 family; Region: NLPC_P60; pfam00877 452652005251 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 452652005252 NlpC/P60 family; Region: NLPC_P60; pfam00877 452652005253 TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926 452652005254 NlpC/P60 family; Region: NLPC_P60; pfam00877 452652005255 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 452652005256 YacP-like NYN domain; Region: NYN_YacP; cl01491 452652005257 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 452652005258 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 452652005259 AsnC family; Region: AsnC_trans_reg; pfam01037 452652005260 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 452652005261 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 452652005262 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 452652005263 catalytic residue [active] 452652005264 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 452652005265 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 452652005266 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 452652005267 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 452652005268 active site 452652005269 phosphorylation site [posttranslational modification] 452652005270 intermolecular recognition site; other site 452652005271 dimerization interface [polypeptide binding]; other site 452652005272 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 452652005273 Subunit I/III interface [polypeptide binding]; other site 452652005274 Cytochrome c; Region: Cytochrom_C; pfam00034 452652005275 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 452652005276 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 452652005277 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 452652005278 iron-sulfur cluster [ion binding]; other site 452652005279 [2Fe-2S] cluster binding site [ion binding]; other site 452652005280 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 452652005281 heme bH binding site [chemical binding]; other site 452652005282 Qi binding site; other site 452652005283 intrachain domain interface; other site 452652005284 heme bL binding site [chemical binding]; other site 452652005285 interchain domain interface [polypeptide binding]; other site 452652005286 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 452652005287 Qo binding site; other site 452652005288 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 452652005289 DNA-binding site [nucleotide binding]; DNA binding site 452652005290 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 452652005291 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 452652005292 active site 452652005293 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652005294 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 452652005295 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 452652005296 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 452652005297 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 452652005298 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 452652005299 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 452652005300 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 452652005301 D-pathway; other site 452652005302 Putative ubiquinol binding site [chemical binding]; other site 452652005303 Low-spin heme (heme b) binding site [chemical binding]; other site 452652005304 Putative water exit pathway; other site 452652005305 Binuclear center (heme o3/CuB) [ion binding]; other site 452652005306 K-pathway; other site 452652005307 Putative proton exit pathway; other site 452652005308 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 452652005309 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 452652005310 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 452652005311 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 452652005312 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 452652005313 catalytic residue [active] 452652005314 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 452652005315 CPxP motif; other site 452652005316 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 452652005317 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 452652005318 substrate binding site [chemical binding]; other site 452652005319 ATP binding site [chemical binding]; other site 452652005320 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 452652005321 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 452652005322 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452652005323 Coenzyme A binding pocket [chemical binding]; other site 452652005324 tyrosine decarboxylase; Region: PLN02880 452652005325 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 452652005326 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 452652005327 catalytic residue [active] 452652005328 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 452652005329 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 452652005330 AsnC family; Region: AsnC_trans_reg; pfam01037 452652005331 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 452652005332 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 452652005333 putative NAD(P) binding site [chemical binding]; other site 452652005334 quinolinate synthetase; Provisional; Region: PRK09375 452652005335 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 452652005336 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 452652005337 Methyltransferase domain; Region: Methyltransf_31; pfam13847 452652005338 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652005339 S-adenosylmethionine binding site [chemical binding]; other site 452652005340 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; pfam02283 452652005341 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 452652005342 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 452652005343 putative dimer interface [polypeptide binding]; other site 452652005344 active site pocket [active] 452652005345 putative cataytic base [active] 452652005346 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 452652005347 multifunctional aminopeptidase A; Provisional; Region: PRK00913 452652005348 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 452652005349 interface (dimer of trimers) [polypeptide binding]; other site 452652005350 Substrate-binding/catalytic site; other site 452652005351 Zn-binding sites [ion binding]; other site 452652005352 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 452652005353 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 452652005354 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 452652005355 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 452652005356 E3 interaction surface; other site 452652005357 lipoyl attachment site [posttranslational modification]; other site 452652005358 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 452652005359 E3 interaction surface; other site 452652005360 lipoyl attachment site [posttranslational modification]; other site 452652005361 e3 binding domain; Region: E3_binding; pfam02817 452652005362 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 452652005363 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 452652005364 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 452652005365 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 452652005366 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452652005367 Coenzyme A binding pocket [chemical binding]; other site 452652005368 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652005369 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 452652005370 NAD(P) binding site [chemical binding]; other site 452652005371 active site 452652005372 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 452652005373 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652005374 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 452652005375 NAD(P) binding site [chemical binding]; other site 452652005376 active site 452652005377 GAF domain; Region: GAF; pfam01590 452652005378 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 452652005379 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 452652005380 lipoyl synthase; Provisional; Region: PRK05481 452652005381 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 452652005382 FeS/SAM binding site; other site 452652005383 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 452652005384 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 452652005385 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 452652005386 RDD family; Region: RDD; pfam06271 452652005387 glutamine synthetase, type I; Region: GlnA; TIGR00653 452652005388 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 452652005389 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 452652005390 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 452652005391 DDE superfamily endonuclease; Region: DDE_3; pfam13358 452652005392 Winged helix-turn helix; Region: HTH_29; pfam13551 452652005393 Winged helix-turn helix; Region: HTH_33; pfam13592 452652005394 Winged helix-turn helix; Region: HTH_29; pfam13551 452652005395 Homeodomain-like domain; Region: HTH_23; cl17451 452652005396 Winged helix-turn helix; Region: HTH_33; pfam13592 452652005397 DDE superfamily endonuclease; Region: DDE_3; pfam13358 452652005398 potential frameshift: common BLAST hit: gi|345013420|ref|YP_004815774.1| transposase IS4 family protein 452652005399 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 452652005400 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 452652005401 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 452652005402 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 452652005403 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 452652005404 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 452652005405 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 452652005406 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 452652005407 AAA domain; Region: AAA_22; pfam13401 452652005408 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 452652005409 DDE superfamily endonuclease; Region: DDE_4; pfam13359 452652005410 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 452652005411 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 452652005412 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 452652005413 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 452652005414 Competence-damaged protein; Region: CinA; pfam02464 452652005415 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 452652005416 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 452652005417 putative hydrophobic ligand binding site [chemical binding]; other site 452652005418 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 452652005419 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452652005420 PAS fold; Region: PAS_3; pfam08447 452652005421 putative active site [active] 452652005422 heme pocket [chemical binding]; other site 452652005423 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 452652005424 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 452652005425 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 452652005426 substrate binding pocket [chemical binding]; other site 452652005427 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 452652005428 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 452652005429 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 452652005430 DNA binding residues [nucleotide binding] 452652005431 H+ Antiporter protein; Region: 2A0121; TIGR00900 452652005432 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652005433 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652005434 dimerization interface [polypeptide binding]; other site 452652005435 DNA binding residues [nucleotide binding] 452652005436 Condensation domain; Region: Condensation; pfam00668 452652005437 acyl carrier protein; Provisional; Region: PRK07081 452652005438 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452652005439 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 452652005440 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452652005441 active site 452652005442 CoA binding site [chemical binding]; other site 452652005443 AMP binding site [chemical binding]; other site 452652005444 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 452652005445 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 452652005446 tetramer interface [polypeptide binding]; other site 452652005447 active site 452652005448 Mg2+/Mn2+ binding site [ion binding]; other site 452652005449 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 452652005450 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 452652005451 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 452652005452 catalytic residue [active] 452652005453 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 452652005454 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 452652005455 acyl-activating enzyme (AAE) consensus motif; other site 452652005456 AMP binding site [chemical binding]; other site 452652005457 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 452652005458 nucleotide binding site [chemical binding]; other site 452652005459 substrate binding site [chemical binding]; other site 452652005460 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 452652005461 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 452652005462 catalytic residue [active] 452652005463 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 452652005464 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 452652005465 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 452652005466 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652005467 Walker A/P-loop; other site 452652005468 ATP binding site [chemical binding]; other site 452652005469 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 452652005470 active site 452652005471 iron coordination sites [ion binding]; other site 452652005472 substrate binding pocket [chemical binding]; other site 452652005473 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 452652005474 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 452652005475 PYR/PP interface [polypeptide binding]; other site 452652005476 dimer interface [polypeptide binding]; other site 452652005477 TPP binding site [chemical binding]; other site 452652005478 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 452652005479 TPP-binding site [chemical binding]; other site 452652005480 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 452652005481 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 452652005482 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 452652005483 Domain of unknown function (DUF397); Region: DUF397; pfam04149 452652005484 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 452652005485 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652005486 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652005487 active site 452652005488 phosphorylation site [posttranslational modification] 452652005489 intermolecular recognition site; other site 452652005490 dimerization interface [polypeptide binding]; other site 452652005491 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652005492 DNA binding residues [nucleotide binding] 452652005493 dimerization interface [polypeptide binding]; other site 452652005494 Histidine kinase; Region: HisKA_3; pfam07730 452652005495 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652005496 ATP binding site [chemical binding]; other site 452652005497 Mg2+ binding site [ion binding]; other site 452652005498 G-X-G motif; other site 452652005499 MMPL family; Region: MMPL; pfam03176 452652005500 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 452652005501 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452652005502 binding surface 452652005503 TPR motif; other site 452652005504 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452652005505 binding surface 452652005506 TPR motif; other site 452652005507 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 452652005508 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 452652005509 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 452652005510 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 452652005511 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652005512 NAD(P) binding site [chemical binding]; other site 452652005513 active site 452652005514 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 452652005515 Protein export membrane protein; Region: SecD_SecF; cl14618 452652005516 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 452652005517 FAD binding domain; Region: FAD_binding_3; pfam01494 452652005518 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 452652005519 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 452652005520 motif II; other site 452652005521 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 452652005522 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 452652005523 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 452652005524 DNA binding site [nucleotide binding] 452652005525 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 452652005526 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652005527 MFS/sugar transport protein; Region: MFS_2; pfam13347 452652005528 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 452652005529 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 452652005530 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 452652005531 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 452652005532 catalytic residue [active] 452652005533 Predicted transcriptional regulators [Transcription]; Region: COG1695 452652005534 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 452652005535 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 452652005536 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 452652005537 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 452652005538 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 452652005539 tetracycline repressor protein TetR; Provisional; Region: PRK13756 452652005540 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652005541 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 452652005542 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 452652005543 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652005544 Proteins of 100 residues with WXG; Region: WXG100; cl02005 452652005545 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 452652005546 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 452652005547 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 452652005548 substrate binding pocket [chemical binding]; other site 452652005549 membrane-bound complex binding site; other site 452652005550 hinge residues; other site 452652005551 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 452652005552 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 452652005553 Cytochrome P450; Region: p450; cl12078 452652005554 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 452652005555 ArsC family; Region: ArsC; pfam03960 452652005556 catalytic residues [active] 452652005557 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 452652005558 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 452652005559 FAD binding pocket [chemical binding]; other site 452652005560 FAD binding motif [chemical binding]; other site 452652005561 phosphate binding motif [ion binding]; other site 452652005562 NAD binding pocket [chemical binding]; other site 452652005563 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG4034 452652005564 Domain of unknown function (DUF397); Region: DUF397; pfam04149 452652005565 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 452652005566 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652005567 non-specific DNA binding site [nucleotide binding]; other site 452652005568 salt bridge; other site 452652005569 sequence-specific DNA binding site [nucleotide binding]; other site 452652005570 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 452652005571 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 452652005572 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 452652005573 domain interfaces; other site 452652005574 active site 452652005575 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG4034 452652005576 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 452652005577 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 452652005578 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 452652005579 NAD binding site [chemical binding]; other site 452652005580 substrate binding site [chemical binding]; other site 452652005581 catalytic Zn binding site [ion binding]; other site 452652005582 structural Zn binding site [ion binding]; other site 452652005583 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 452652005584 classical (c) SDRs; Region: SDR_c; cd05233 452652005585 NAD(P) binding site [chemical binding]; other site 452652005586 active site 452652005587 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 452652005588 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652005589 Hemerythrin-like domain; Region: Hr-like; cd12108 452652005590 Fe binding site [ion binding]; other site 452652005591 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 452652005592 Putative esterase; Region: Esterase; pfam00756 452652005593 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 452652005594 classical (c) SDRs; Region: SDR_c; cd05233 452652005595 NAD(P) binding site [chemical binding]; other site 452652005596 active site 452652005597 Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317 452652005598 active site 452652005599 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 452652005600 Ca binding site [ion binding]; other site 452652005601 catalytic site [active] 452652005602 Aamy_C domain; Region: Aamy_C; smart00632 452652005603 Carbohydrate binding domain (family 25); Region: CBM_25; cl04060 452652005604 Alpha-amylase, C-terminal CBM20 (carbohydrate-binding module, family 20) domain. This domain is found in several bacterial and fungal alpha-amylases including the maltopentaose-forming amylases (G5-amylases). Most alpha-amylases have, in addition to the...; Region: CBM20_alpha_amylase; cd05808 452652005605 starch-binding site 2 [chemical binding]; other site 452652005606 starch-binding site 1 [chemical binding]; other site 452652005607 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 452652005608 glycosyltransferase, MGT family; Region: MGT; TIGR01426 452652005609 active site 452652005610 TDP-binding site; other site 452652005611 acceptor substrate-binding pocket; other site 452652005612 homodimer interface [polypeptide binding]; other site 452652005613 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 452652005614 Nitrogen regulatory protein P-II; Region: P-II; smart00938 452652005615 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 452652005616 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 452652005617 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 452652005618 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 452652005619 active site 452652005620 Zn binding site [ion binding]; other site 452652005621 Putative Ig domain; Region: He_PIG; pfam05345 452652005622 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 452652005623 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 452652005624 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 452652005625 active site 452652005626 catalytic site [active] 452652005627 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 452652005628 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 452652005629 carbohydrate binding site [chemical binding]; other site 452652005630 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 452652005631 carbohydrate binding site [chemical binding]; other site 452652005632 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 452652005633 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 452652005634 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 452652005635 Ca binding site [ion binding]; other site 452652005636 active site 452652005637 catalytic site [active] 452652005638 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 452652005639 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 452652005640 active site 452652005641 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 452652005642 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 452652005643 metal binding triad; other site 452652005644 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 452652005645 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 452652005646 metal binding triad; other site 452652005647 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 452652005648 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 452652005649 Protein of unknown function (DUF3344); Region: DUF3344; pfam11824 452652005650 AAA ATPase domain; Region: AAA_16; pfam13191 452652005651 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452652005652 binding surface 452652005653 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452652005654 TPR motif; other site 452652005655 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 452652005656 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 452652005657 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 452652005658 NAD synthetase; Provisional; Region: PRK13981 452652005659 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 452652005660 multimer interface [polypeptide binding]; other site 452652005661 active site 452652005662 catalytic triad [active] 452652005663 protein interface 1 [polypeptide binding]; other site 452652005664 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 452652005665 homodimer interface [polypeptide binding]; other site 452652005666 NAD binding pocket [chemical binding]; other site 452652005667 ATP binding pocket [chemical binding]; other site 452652005668 Mg binding site [ion binding]; other site 452652005669 active-site loop [active] 452652005670 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 452652005671 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 452652005672 putative catalytic site [active] 452652005673 putative phosphate binding site [ion binding]; other site 452652005674 putative metal binding site [ion binding]; other site 452652005675 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652005676 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652005677 Major Facilitator Superfamily; Region: MFS_1; pfam07690 452652005678 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652005679 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652005680 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 452652005681 oligomerization interface [polypeptide binding]; other site 452652005682 active site 452652005683 metal binding site [ion binding]; metal-binding site 452652005684 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652005685 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 452652005686 Walker A/P-loop; other site 452652005687 ATP binding site [chemical binding]; other site 452652005688 Q-loop/lid; other site 452652005689 ABC transporter signature motif; other site 452652005690 Walker B; other site 452652005691 D-loop; other site 452652005692 H-loop/switch region; other site 452652005693 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 452652005694 ABC-2 type transporter; Region: ABC2_membrane; cl17235 452652005695 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 452652005696 Predicted ATPase [General function prediction only]; Region: COG3903 452652005697 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 452652005698 Peptidase family M50; Region: Peptidase_M50; pfam02163 452652005699 active site 452652005700 putative substrate binding region [chemical binding]; other site 452652005701 NADPH-dependent F420 reductase; Region: npdG; TIGR01915 452652005702 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 452652005703 enterobactin exporter EntS; Provisional; Region: PRK10489 452652005704 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 452652005705 active site 452652005706 Bifunctional DNA primase/polymerase, N-terminal; Region: Prim-Pol; smart00943 452652005707 TniQ; Region: TniQ; pfam06527 452652005708 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452652005709 Coenzyme A binding pocket [chemical binding]; other site 452652005710 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 452652005711 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 452652005712 Walker A/P-loop; other site 452652005713 ATP binding site [chemical binding]; other site 452652005714 Q-loop/lid; other site 452652005715 ABC transporter signature motif; other site 452652005716 Walker B; other site 452652005717 D-loop; other site 452652005718 H-loop/switch region; other site 452652005719 Sterol carrier protein domain; Region: SCP2_2; pfam13530 452652005720 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 452652005721 putative active site [active] 452652005722 putative catalytic site [active] 452652005723 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 452652005724 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 452652005725 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 452652005726 active site 452652005727 catalytic residues [active] 452652005728 metal binding site [ion binding]; metal-binding site 452652005729 DmpG-like communication domain; Region: DmpG_comm; pfam07836 452652005730 acetaldehyde dehydrogenase; Validated; Region: PRK08300 452652005731 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 452652005732 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 452652005733 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 452652005734 nudix motif; other site 452652005735 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 452652005736 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 452652005737 ATP binding site [chemical binding]; other site 452652005738 Mg2+ binding site [ion binding]; other site 452652005739 G-X-G motif; other site 452652005740 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452652005741 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 452652005742 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 452652005743 active site 452652005744 TniQ; Region: TniQ; pfam06527 452652005745 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 452652005746 Integrase core domain; Region: rve; pfam00665 452652005747 AAA domain; Region: AAA_22; pfam13401 452652005748 Bacterial TniB protein; Region: TniB; pfam05621 452652005749 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602 452652005750 ACT domain; Region: ACT_3; pfam10000 452652005751 Family description; Region: ACT_7; pfam13840 452652005752 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 452652005753 Beta-lactamase; Region: Beta-lactamase; pfam00144 452652005754 PAS fold; Region: PAS_4; pfam08448 452652005755 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 452652005756 GAF domain; Region: GAF; cl17456 452652005757 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 452652005758 Domain of unknown function (DUF336); Region: DUF336; pfam03928 452652005759 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 452652005760 Histidine kinase; Region: HisKA_3; pfam07730 452652005761 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652005762 ATP binding site [chemical binding]; other site 452652005763 Mg2+ binding site [ion binding]; other site 452652005764 G-X-G motif; other site 452652005765 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652005766 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652005767 active site 452652005768 phosphorylation site [posttranslational modification] 452652005769 intermolecular recognition site; other site 452652005770 dimerization interface [polypeptide binding]; other site 452652005771 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652005772 DNA binding residues [nucleotide binding] 452652005773 dimerization interface [polypeptide binding]; other site 452652005774 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652005775 ATP binding site [chemical binding]; other site 452652005776 G-X-G motif; other site 452652005777 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652005778 Major Facilitator Superfamily; Region: MFS_1; pfam07690 452652005779 putative substrate translocation pore; other site 452652005780 RNB domain; Region: RNB; pfam00773 452652005781 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 452652005782 hypothetical protein; Validated; Region: PRK02101 452652005783 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 452652005784 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 452652005785 RNA/DNA hybrid binding site [nucleotide binding]; other site 452652005786 active site 452652005787 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 452652005788 catalytic core [active] 452652005789 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 452652005790 Putative zinc ribbon domain; Region: DUF164; pfam02591 452652005791 Uncharacterized conserved protein [Function unknown]; Region: COG0327 452652005792 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 452652005793 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 452652005794 active site 452652005795 ATP binding site [chemical binding]; other site 452652005796 substrate binding site [chemical binding]; other site 452652005797 activation loop (A-loop); other site 452652005798 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 452652005799 active site 452652005800 zinc binding site [ion binding]; other site 452652005801 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 452652005802 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 452652005803 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 452652005804 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 452652005805 NAD binding site [chemical binding]; other site 452652005806 catalytic Zn binding site [ion binding]; other site 452652005807 substrate binding site [chemical binding]; other site 452652005808 structural Zn binding site [ion binding]; other site 452652005809 Peptidase family M48; Region: Peptidase_M48; cl12018 452652005810 Methyltransferase domain; Region: Methyltransf_24; pfam13578 452652005811 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 452652005812 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 452652005813 active site 452652005814 metal binding site [ion binding]; metal-binding site 452652005815 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 452652005816 DNA-binding site [nucleotide binding]; DNA binding site 452652005817 Uncharacterized conserved protein [Function unknown]; Region: COG4278 452652005818 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 452652005819 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 452652005820 DNA-binding site [nucleotide binding]; DNA binding site 452652005821 UTRA domain; Region: UTRA; pfam07702 452652005822 DDE superfamily endonuclease; Region: DDE_5; cl17874 452652005823 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 452652005824 Methyltransferase domain; Region: Methyltransf_31; pfam13847 452652005825 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652005826 S-adenosylmethionine binding site [chemical binding]; other site 452652005827 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 452652005828 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 452652005829 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652005830 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652005831 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 452652005832 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 452652005833 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 452652005834 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 452652005835 Walker A/P-loop; other site 452652005836 ATP binding site [chemical binding]; other site 452652005837 Q-loop/lid; other site 452652005838 ABC transporter signature motif; other site 452652005839 Walker B; other site 452652005840 D-loop; other site 452652005841 H-loop/switch region; other site 452652005842 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 452652005843 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652005844 Walker A/P-loop; other site 452652005845 ATP binding site [chemical binding]; other site 452652005846 Q-loop/lid; other site 452652005847 ABC transporter signature motif; other site 452652005848 Walker B; other site 452652005849 D-loop; other site 452652005850 H-loop/switch region; other site 452652005851 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 452652005852 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 452652005853 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 452652005854 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 452652005855 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 452652005856 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 452652005857 DNA binding residues [nucleotide binding] 452652005858 drug binding residues [chemical binding]; other site 452652005859 dimer interface [polypeptide binding]; other site 452652005860 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 452652005861 beta-clamp/clamp loader binding surface; other site 452652005862 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652005863 putative substrate translocation pore; other site 452652005864 Major Facilitator Superfamily; Region: MFS_1; pfam07690 452652005865 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 452652005866 MarR family; Region: MarR_2; cl17246 452652005867 Glyco_18 domain; Region: Glyco_18; smart00636 452652005868 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 452652005869 active site 452652005870 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 452652005871 aromatic chitin/cellulose binding site residues [chemical binding]; other site 452652005872 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 452652005873 RNAase interaction site [polypeptide binding]; other site 452652005874 MarC family integral membrane protein; Region: MarC; cl00919 452652005875 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 452652005876 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 452652005877 putative DNA binding site [nucleotide binding]; other site 452652005878 putative Zn2+ binding site [ion binding]; other site 452652005879 AsnC family; Region: AsnC_trans_reg; pfam01037 452652005880 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 452652005881 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 452652005882 kynureninase; Region: kynureninase; TIGR01814 452652005883 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 452652005884 catalytic residue [active] 452652005885 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 452652005886 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 452652005887 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 452652005888 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 452652005889 active site 452652005890 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 452652005891 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 452652005892 putative DNA binding site [nucleotide binding]; other site 452652005893 putative Zn2+ binding site [ion binding]; other site 452652005894 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 452652005895 AsnC family; Region: AsnC_trans_reg; pfam01037 452652005896 Uncharacterized conserved protein (DUF2277); Region: DUF2277; cl02349 452652005897 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 452652005898 glyoxylate carboligase; Provisional; Region: PRK11269 452652005899 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 452652005900 PYR/PP interface [polypeptide binding]; other site 452652005901 dimer interface [polypeptide binding]; other site 452652005902 TPP binding site [chemical binding]; other site 452652005903 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 452652005904 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 452652005905 TPP-binding site [chemical binding]; other site 452652005906 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 452652005907 NADH(P)-binding; Region: NAD_binding_10; pfam13460 452652005908 NAD binding site [chemical binding]; other site 452652005909 substrate binding site [chemical binding]; other site 452652005910 putative active site [active] 452652005911 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 452652005912 Omega-hydroxypalmitate O-feruloyl transferase; Region: PLN02481; cl03601 452652005913 Flavoprotein; Region: Flavoprotein; cl08021 452652005914 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 452652005915 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 452652005916 active site 452652005917 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452652005918 TPR repeat; Region: TPR_11; pfam13414 452652005919 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452652005920 binding surface 452652005921 TPR motif; other site 452652005922 AAA ATPase domain; Region: AAA_16; pfam13191 452652005923 FOG: WD40 repeat [General function prediction only]; Region: COG2319 452652005924 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 452652005925 structural tetrad; other site 452652005926 FOG: WD40 repeat [General function prediction only]; Region: COG2319 452652005927 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 452652005928 structural tetrad; other site 452652005929 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 452652005930 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 452652005931 DDE superfamily endonuclease; Region: DDE_3; pfam13358 452652005932 Winged helix-turn helix; Region: HTH_29; pfam13551 452652005933 Winged helix-turn helix; Region: HTH_33; pfam13592 452652005934 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 452652005935 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 452652005936 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 452652005937 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 452652005938 active site 452652005939 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 452652005940 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 452652005941 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 452652005942 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 452652005943 putative metal binding site [ion binding]; other site 452652005944 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 452652005945 Tellurium resistance protein; Region: Tellurium_res; pfam10138 452652005946 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 452652005947 putative metal binding site [ion binding]; other site 452652005948 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 452652005949 hypothetical protein; Provisional; Region: PRK14013 452652005950 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 452652005951 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 452652005952 putative metal binding site [ion binding]; other site 452652005953 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 452652005954 Catalytic domain of Protein Kinases; Region: PKc; cd00180 452652005955 active site 452652005956 ATP binding site [chemical binding]; other site 452652005957 substrate binding site [chemical binding]; other site 452652005958 activation loop (A-loop); other site 452652005959 PQQ-like domain; Region: PQQ_2; pfam13360 452652005960 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 452652005961 active site 452652005962 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 452652005963 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 452652005964 putative metal binding site [ion binding]; other site 452652005965 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 452652005966 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 452652005967 dimer interface [polypeptide binding]; other site 452652005968 catalytic triad [active] 452652005969 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 452652005970 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 452652005971 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 452652005972 dimer interface [polypeptide binding]; other site 452652005973 TPP-binding site [chemical binding]; other site 452652005974 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 452652005975 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652005976 Major Facilitator Superfamily; Region: MFS_1; pfam07690 452652005977 putative substrate translocation pore; other site 452652005978 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652005979 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 452652005980 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652005981 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 452652005982 Histidine kinase; Region: HisKA_3; pfam07730 452652005983 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 452652005984 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652005985 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652005986 active site 452652005987 phosphorylation site [posttranslational modification] 452652005988 intermolecular recognition site; other site 452652005989 dimerization interface [polypeptide binding]; other site 452652005990 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652005991 DNA binding residues [nucleotide binding] 452652005992 dimerization interface [polypeptide binding]; other site 452652005993 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 452652005994 Protein of unknown function (DUF419); Region: DUF419; pfam04237 452652005995 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 452652005996 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 452652005997 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 452652005998 active site 452652005999 catalytic tetrad [active] 452652006000 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 452652006001 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 452652006002 DNA binding residues [nucleotide binding] 452652006003 putative dimer interface [polypeptide binding]; other site 452652006004 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 452652006005 Beta-lactamase; Region: Beta-lactamase; pfam00144 452652006006 Pirin-related protein [General function prediction only]; Region: COG1741 452652006007 Pirin; Region: Pirin; pfam02678 452652006008 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 452652006009 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 452652006010 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 452652006011 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 452652006012 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 452652006013 dimer interface [polypeptide binding]; other site 452652006014 active site 452652006015 CoA binding pocket [chemical binding]; other site 452652006016 acyl carrier protein; Provisional; Region: acpP; PRK00982 452652006017 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 452652006018 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 452652006019 dimer interface [polypeptide binding]; other site 452652006020 active site 452652006021 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 452652006022 Transcriptional regulators [Transcription]; Region: MarR; COG1846 452652006023 MarR family; Region: MarR; pfam01047 452652006024 MarR family; Region: MarR_2; cl17246 452652006025 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 452652006026 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 452652006027 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 452652006028 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 452652006029 catalytic residue [active] 452652006030 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 452652006031 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452652006032 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452652006033 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 452652006034 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 452652006035 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 452652006036 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 452652006037 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 452652006038 nucleotide binding site [chemical binding]; other site 452652006039 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 452652006040 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652006041 catalytic residue [active] 452652006042 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 452652006043 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 452652006044 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 452652006045 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 452652006046 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652006047 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 452652006048 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452652006049 DNA binding residues [nucleotide binding] 452652006050 DNA primase; Validated; Region: dnaG; PRK05667 452652006051 CHC2 zinc finger; Region: zf-CHC2; pfam01807 452652006052 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 452652006053 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 452652006054 active site 452652006055 metal binding site [ion binding]; metal-binding site 452652006056 interdomain interaction site; other site 452652006057 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 452652006058 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 452652006059 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 452652006060 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 452652006061 Zn2+ binding site [ion binding]; other site 452652006062 Mg2+ binding site [ion binding]; other site 452652006063 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 452652006064 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 452652006065 dimerization interface [polypeptide binding]; other site 452652006066 putative DNA binding site [nucleotide binding]; other site 452652006067 putative Zn2+ binding site [ion binding]; other site 452652006068 H+ Antiporter protein; Region: 2A0121; TIGR00900 452652006069 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 452652006070 putative active site [active] 452652006071 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 452652006072 active site 452652006073 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452652006074 nitrite reductase subunit NirD; Provisional; Region: PRK14989 452652006075 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 452652006076 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 452652006077 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 452652006078 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 452652006079 active site 452652006080 catalytic triad [active] 452652006081 oxyanion hole [active] 452652006082 PAC2 family; Region: PAC2; pfam09754 452652006083 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 452652006084 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 452652006085 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 452652006086 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 452652006087 active site 452652006088 barstar interaction site; other site 452652006089 pyruvate phosphate dikinase; Provisional; Region: PRK09279 452652006090 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 452652006091 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 452652006092 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 452652006093 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 452652006094 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 452652006095 FMN binding site [chemical binding]; other site 452652006096 active site 452652006097 catalytic residues [active] 452652006098 substrate binding site [chemical binding]; other site 452652006099 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 452652006100 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652006101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652006102 active site 452652006103 phosphorylation site [posttranslational modification] 452652006104 intermolecular recognition site; other site 452652006105 dimerization interface [polypeptide binding]; other site 452652006106 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652006107 DNA binding residues [nucleotide binding] 452652006108 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 452652006109 Histidine kinase; Region: HisKA_3; pfam07730 452652006110 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 452652006111 glycyl-tRNA synthetase; Provisional; Region: PRK04173 452652006112 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 452652006113 motif 1; other site 452652006114 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 452652006115 active site 452652006116 motif 2; other site 452652006117 motif 3; other site 452652006118 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 452652006119 anticodon binding site; other site 452652006120 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 452652006121 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 452652006122 intersubunit interface [polypeptide binding]; other site 452652006123 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 452652006124 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 452652006125 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 452652006126 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 452652006127 ABC-ATPase subunit interface; other site 452652006128 dimer interface [polypeptide binding]; other site 452652006129 putative PBP binding regions; other site 452652006130 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 452652006131 metal binding site 2 [ion binding]; metal-binding site 452652006132 putative DNA binding helix; other site 452652006133 metal binding site 1 [ion binding]; metal-binding site 452652006134 dimer interface [polypeptide binding]; other site 452652006135 structural Zn2+ binding site [ion binding]; other site 452652006136 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 452652006137 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 452652006138 catalytic residue [active] 452652006139 putative FPP diphosphate binding site; other site 452652006140 putative FPP binding hydrophobic cleft; other site 452652006141 dimer interface [polypeptide binding]; other site 452652006142 putative IPP diphosphate binding site; other site 452652006143 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 452652006144 Recombination protein O N terminal; Region: RecO_N; pfam11967 452652006145 Recombination protein O C terminal; Region: RecO_C; pfam02565 452652006146 tellurium resistance terB-like protein; Region: terB_like; cl11965 452652006147 2-isopropylmalate synthase; Validated; Region: PRK03739 452652006148 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 452652006149 active site 452652006150 catalytic residues [active] 452652006151 metal binding site [ion binding]; metal-binding site 452652006152 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 452652006153 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 452652006154 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 452652006155 GTPase Era; Reviewed; Region: era; PRK00089 452652006156 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 452652006157 G1 box; other site 452652006158 GTP/Mg2+ binding site [chemical binding]; other site 452652006159 Switch I region; other site 452652006160 G2 box; other site 452652006161 Switch II region; other site 452652006162 G3 box; other site 452652006163 G4 box; other site 452652006164 G5 box; other site 452652006165 KH domain; Region: KH_2; pfam07650 452652006166 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 452652006167 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 452652006168 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 452652006169 active site 452652006170 catalytic tetrad [active] 452652006171 Domain of unknown function DUF21; Region: DUF21; pfam01595 452652006172 FOG: CBS domain [General function prediction only]; Region: COG0517 452652006173 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 452652006174 Transporter associated domain; Region: CorC_HlyC; smart01091 452652006175 metal-binding heat shock protein; Provisional; Region: PRK00016 452652006176 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 452652006177 PhoH-like protein; Region: PhoH; pfam02562 452652006178 ribonuclease Z; Reviewed; Region: PRK00055 452652006179 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 452652006180 nucleotide binding site/active site [active] 452652006181 HIT family signature motif; other site 452652006182 catalytic residue [active] 452652006183 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 452652006184 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 452652006185 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 452652006186 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 452652006187 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 452652006188 protein binding site [polypeptide binding]; other site 452652006189 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 452652006190 Domain interface; other site 452652006191 Peptide binding site; other site 452652006192 Active site tetrad [active] 452652006193 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 452652006194 chaperone protein DnaJ; Provisional; Region: PRK14278 452652006195 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 452652006196 HSP70 interaction site [polypeptide binding]; other site 452652006197 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 452652006198 substrate binding site [polypeptide binding]; other site 452652006199 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 452652006200 Zn binding sites [ion binding]; other site 452652006201 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 452652006202 dimer interface [polypeptide binding]; other site 452652006203 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 452652006204 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 452652006205 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 452652006206 heat shock protein HtpX; Provisional; Region: PRK02391 452652006207 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 452652006208 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 452652006209 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652006210 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 452652006211 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 452652006212 FeS/SAM binding site; other site 452652006213 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 452652006214 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 452652006215 acyl-activating enzyme (AAE) consensus motif; other site 452652006216 putative AMP binding site [chemical binding]; other site 452652006217 putative active site [active] 452652006218 putative CoA binding site [chemical binding]; other site 452652006219 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 452652006220 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 452652006221 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652006222 Walker A/P-loop; other site 452652006223 ATP binding site [chemical binding]; other site 452652006224 Q-loop/lid; other site 452652006225 ABC transporter signature motif; other site 452652006226 Walker B; other site 452652006227 D-loop; other site 452652006228 H-loop/switch region; other site 452652006229 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 452652006230 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 452652006231 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 452652006232 Walker A/P-loop; other site 452652006233 ATP binding site [chemical binding]; other site 452652006234 Q-loop/lid; other site 452652006235 ABC transporter signature motif; other site 452652006236 Walker B; other site 452652006237 D-loop; other site 452652006238 H-loop/switch region; other site 452652006239 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 452652006240 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 452652006241 GTP-binding protein LepA; Provisional; Region: PRK05433 452652006242 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 452652006243 G1 box; other site 452652006244 putative GEF interaction site [polypeptide binding]; other site 452652006245 GTP/Mg2+ binding site [chemical binding]; other site 452652006246 Switch I region; other site 452652006247 G2 box; other site 452652006248 G3 box; other site 452652006249 Switch II region; other site 452652006250 G4 box; other site 452652006251 G5 box; other site 452652006252 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 452652006253 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 452652006254 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 452652006255 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 452652006256 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 452652006257 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 452652006258 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 452652006259 Competence protein; Region: Competence; pfam03772 452652006260 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 452652006261 SLBB domain; Region: SLBB; pfam10531 452652006262 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 452652006263 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 452652006264 EDD domain protein, DegV family; Region: DegV; TIGR00762 452652006265 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 452652006266 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 452652006267 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 452652006268 HIGH motif; other site 452652006269 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 452652006270 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 452652006271 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 452652006272 active site 452652006273 KMSKS motif; other site 452652006274 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 452652006275 tRNA binding surface [nucleotide binding]; other site 452652006276 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 452652006277 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 452652006278 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 452652006279 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 452652006280 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 452652006281 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 452652006282 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 452652006283 active site 452652006284 (T/H)XGH motif; other site 452652006285 Peptidase family M48; Region: Peptidase_M48; pfam01435 452652006286 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 452652006287 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 452652006288 putative catalytic cysteine [active] 452652006289 gamma-glutamyl kinase; Provisional; Region: PRK05429 452652006290 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 452652006291 substrate binding site [chemical binding]; other site 452652006292 nucleotide binding site [chemical binding]; other site 452652006293 PUA domain; Region: PUA; pfam01472 452652006294 GTPase CgtA; Reviewed; Region: obgE; PRK12296 452652006295 GTP1/OBG; Region: GTP1_OBG; pfam01018 452652006296 Obg GTPase; Region: Obg; cd01898 452652006297 G1 box; other site 452652006298 GTP/Mg2+ binding site [chemical binding]; other site 452652006299 Switch I region; other site 452652006300 G2 box; other site 452652006301 G3 box; other site 452652006302 Switch II region; other site 452652006303 G4 box; other site 452652006304 G5 box; other site 452652006305 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 452652006306 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 452652006307 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 452652006308 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 452652006309 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 452652006310 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 452652006311 homodimer interface [polypeptide binding]; other site 452652006312 oligonucleotide binding site [chemical binding]; other site 452652006313 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 452652006314 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 452652006315 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 452652006316 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 452652006317 B12 binding site [chemical binding]; other site 452652006318 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 452652006319 FeS/SAM binding site; other site 452652006320 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 452652006321 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 452652006322 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 452652006323 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 452652006324 rod shape-determining protein MreC; Provisional; Region: PRK13922 452652006325 rod shape-determining protein MreC; Region: MreC; pfam04085 452652006326 rod shape-determining protein MreB; Provisional; Region: PRK13927 452652006327 MreB and similar proteins; Region: MreB_like; cd10225 452652006328 nucleotide binding site [chemical binding]; other site 452652006329 Mg binding site [ion binding]; other site 452652006330 putative protofilament interaction site [polypeptide binding]; other site 452652006331 RodZ interaction site [polypeptide binding]; other site 452652006332 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 452652006333 active site 452652006334 multimer interface [polypeptide binding]; other site 452652006335 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 452652006336 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 452652006337 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 452652006338 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 452652006339 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 452652006340 active site 452652006341 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 452652006342 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 452652006343 putative active site [active] 452652006344 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 452652006345 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 452652006346 active site 452652006347 HIGH motif; other site 452652006348 nucleotide binding site [chemical binding]; other site 452652006349 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 452652006350 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 452652006351 active site 452652006352 KMSKS motif; other site 452652006353 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 452652006354 tRNA binding surface [nucleotide binding]; other site 452652006355 anticodon binding site; other site 452652006356 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 452652006357 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 452652006358 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 452652006359 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452652006360 Walker A motif; other site 452652006361 ATP binding site [chemical binding]; other site 452652006362 Walker B motif; other site 452652006363 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 452652006364 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 452652006365 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 452652006366 oligomer interface [polypeptide binding]; other site 452652006367 active site residues [active] 452652006368 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 452652006369 Clp protease; Region: CLP_protease; pfam00574 452652006370 oligomer interface [polypeptide binding]; other site 452652006371 active site residues [active] 452652006372 trigger factor; Region: tig; TIGR00115 452652006373 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 452652006374 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 452652006375 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 452652006376 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 452652006377 Peptidase family M23; Region: Peptidase_M23; pfam01551 452652006378 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 452652006379 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 452652006380 BioY family; Region: BioY; pfam02632 452652006381 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 452652006382 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 452652006383 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 452652006384 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 452652006385 Zn binding site [ion binding]; other site 452652006386 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 452652006387 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652006388 dimer interface [polypeptide binding]; other site 452652006389 conserved gate region; other site 452652006390 putative PBP binding loops; other site 452652006391 ABC-ATPase subunit interface; other site 452652006392 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 452652006393 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652006394 putative PBP binding loops; other site 452652006395 dimer interface [polypeptide binding]; other site 452652006396 ABC-ATPase subunit interface; other site 452652006397 carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein; Region: chitin_NgcE; TIGR03851 452652006398 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 452652006399 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 452652006400 Glyco_18 domain; Region: Glyco_18; smart00636 452652006401 active site 452652006402 aconitate hydratase; Validated; Region: PRK09277 452652006403 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 452652006404 substrate binding site [chemical binding]; other site 452652006405 ligand binding site [chemical binding]; other site 452652006406 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 452652006407 substrate binding site [chemical binding]; other site 452652006408 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 452652006409 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652006410 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 452652006411 homotetrameric interface [polypeptide binding]; other site 452652006412 putative active site [active] 452652006413 metal binding site [ion binding]; metal-binding site 452652006414 ornithine carbamoyltransferase; Validated; Region: PRK02102 452652006415 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 452652006416 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 452652006417 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 452652006418 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 452652006419 active site 452652006420 metal binding site [ion binding]; metal-binding site 452652006421 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 452652006422 Methyltransferase domain; Region: Methyltransf_12; pfam08242 452652006423 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 452652006424 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 452652006425 putative trimer interface [polypeptide binding]; other site 452652006426 putative CoA binding site [chemical binding]; other site 452652006427 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 452652006428 homodimer interface [polypeptide binding]; other site 452652006429 chemical substrate binding site [chemical binding]; other site 452652006430 oligomer interface [polypeptide binding]; other site 452652006431 metal binding site [ion binding]; metal-binding site 452652006432 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652006433 AAA domain; Region: AAA_21; pfam13304 452652006434 Walker A/P-loop; other site 452652006435 ATP binding site [chemical binding]; other site 452652006436 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 452652006437 Methyltransferase domain; Region: Methyltransf_11; pfam08241 452652006438 S-adenosylmethionine binding site [chemical binding]; other site 452652006439 HicB family; Region: HicB; pfam05534 452652006440 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 452652006441 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 452652006442 active site 452652006443 catalytic site [active] 452652006444 substrate binding site [chemical binding]; other site 452652006445 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 452652006446 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 452652006447 putative metal binding site [ion binding]; other site 452652006448 TRAM domain; Region: TRAM; pfam01938 452652006449 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 452652006450 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652006451 S-adenosylmethionine binding site [chemical binding]; other site 452652006452 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 452652006453 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 452652006454 TrkA-N domain; Region: TrkA_N; pfam02254 452652006455 TrkA-C domain; Region: TrkA_C; pfam02080 452652006456 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 452652006457 TrkA-N domain; Region: TrkA_N; pfam02254 452652006458 TrkA-C domain; Region: TrkA_C; pfam02080 452652006459 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 452652006460 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 452652006461 generic binding surface II; other site 452652006462 ssDNA binding site; other site 452652006463 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 452652006464 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652006465 active site 452652006466 phosphorylation site [posttranslational modification] 452652006467 intermolecular recognition site; other site 452652006468 dimerization interface [polypeptide binding]; other site 452652006469 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 452652006470 DNA binding site [nucleotide binding] 452652006471 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 452652006472 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 452652006473 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 452652006474 Ligand Binding Site [chemical binding]; other site 452652006475 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452652006476 dimer interface [polypeptide binding]; other site 452652006477 phosphorylation site [posttranslational modification] 452652006478 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652006479 ATP binding site [chemical binding]; other site 452652006480 Mg2+ binding site [ion binding]; other site 452652006481 G-X-G motif; other site 452652006482 Patatin-like phospholipase; Region: Patatin; pfam01734 452652006483 nucleophile elbow; other site 452652006484 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 452652006485 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 452652006486 Walker A/P-loop; other site 452652006487 ATP binding site [chemical binding]; other site 452652006488 Q-loop/lid; other site 452652006489 ABC transporter signature motif; other site 452652006490 Walker B; other site 452652006491 D-loop; other site 452652006492 H-loop/switch region; other site 452652006493 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 452652006494 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 452652006495 Walker A/P-loop; other site 452652006496 ATP binding site [chemical binding]; other site 452652006497 Q-loop/lid; other site 452652006498 ABC transporter signature motif; other site 452652006499 Walker B; other site 452652006500 D-loop; other site 452652006501 H-loop/switch region; other site 452652006502 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 452652006503 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652006504 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452652006505 DNA binding residues [nucleotide binding] 452652006506 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 452652006507 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 452652006508 active site 452652006509 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 452652006510 dimer interface [polypeptide binding]; other site 452652006511 catalytic triad [active] 452652006512 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 452652006513 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 452652006514 active site 452652006515 HIGH motif; other site 452652006516 dimer interface [polypeptide binding]; other site 452652006517 KMSKS motif; other site 452652006518 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 452652006519 nudix motif; other site 452652006520 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 452652006521 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 452652006522 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652006523 Walker A/P-loop; other site 452652006524 ATP binding site [chemical binding]; other site 452652006525 Q-loop/lid; other site 452652006526 ABC transporter signature motif; other site 452652006527 Walker B; other site 452652006528 D-loop; other site 452652006529 H-loop/switch region; other site 452652006530 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 452652006531 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 452652006532 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652006533 Walker A/P-loop; other site 452652006534 ATP binding site [chemical binding]; other site 452652006535 Q-loop/lid; other site 452652006536 ABC transporter signature motif; other site 452652006537 Walker B; other site 452652006538 D-loop; other site 452652006539 H-loop/switch region; other site 452652006540 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652006541 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652006542 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 452652006543 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 452652006544 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 452652006545 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 452652006546 ATP-grasp domain; Region: ATP-grasp_4; cl17255 452652006547 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 452652006548 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 452652006549 carboxyltransferase (CT) interaction site; other site 452652006550 biotinylation site [posttranslational modification]; other site 452652006551 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 452652006552 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 452652006553 active site 452652006554 catalytic residues [active] 452652006555 metal binding site [ion binding]; metal-binding site 452652006556 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 452652006557 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 452652006558 active site 452652006559 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 452652006560 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 452652006561 Ligand Binding Site [chemical binding]; other site 452652006562 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 452652006563 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 452652006564 motif II; other site 452652006565 potential frameshift: common BLAST hit: gi|345010718|ref|YP_004813072.1| helix-turn-helix domain-containing protein 452652006566 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652006567 active site 452652006568 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 452652006569 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 452652006570 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 452652006571 conserved cys residue [active] 452652006572 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452652006573 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 452652006574 catalytic site [active] 452652006575 putative active site [active] 452652006576 putative substrate binding site [chemical binding]; other site 452652006577 dimer interface [polypeptide binding]; other site 452652006578 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 452652006579 CoenzymeA binding site [chemical binding]; other site 452652006580 subunit interaction site [polypeptide binding]; other site 452652006581 PHB binding site; other site 452652006582 Transcriptional regulators [Transcription]; Region: PurR; COG1609 452652006583 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 452652006584 DNA binding site [nucleotide binding] 452652006585 domain linker motif; other site 452652006586 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 452652006587 putative dimerization interface [polypeptide binding]; other site 452652006588 putative ligand binding site [chemical binding]; other site 452652006589 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 452652006590 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 452652006591 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 452652006592 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652006593 dimer interface [polypeptide binding]; other site 452652006594 conserved gate region; other site 452652006595 ABC-ATPase subunit interface; other site 452652006596 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 452652006597 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652006598 dimer interface [polypeptide binding]; other site 452652006599 conserved gate region; other site 452652006600 putative PBP binding loops; other site 452652006601 ABC-ATPase subunit interface; other site 452652006602 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 452652006603 beta-galactosidase; Region: BGL; TIGR03356 452652006604 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 452652006605 putative active site [active] 452652006606 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 452652006607 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 452652006608 catalytic core [active] 452652006609 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 452652006610 Part of AAA domain; Region: AAA_19; pfam13245 452652006611 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 452652006612 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 452652006613 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 452652006614 4Fe-4S binding domain; Region: Fer4_4; pfam12800 452652006615 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 452652006616 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 452652006617 Cysteine-rich domain; Region: CCG; pfam02754 452652006618 Cysteine-rich domain; Region: CCG; pfam02754 452652006619 Transcriptional regulators [Transcription]; Region: GntR; COG1802 452652006620 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 452652006621 DNA-binding site [nucleotide binding]; DNA binding site 452652006622 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 452652006623 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 452652006624 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 452652006625 active site 452652006626 dimer interface [polypeptide binding]; other site 452652006627 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 452652006628 dimer interface [polypeptide binding]; other site 452652006629 active site 452652006630 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 452652006631 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 452652006632 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 452652006633 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 452652006634 active site 452652006635 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 452652006636 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 452652006637 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 452652006638 putative NADP binding site [chemical binding]; other site 452652006639 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 452652006640 active site 452652006641 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 452652006642 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 452652006643 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452652006644 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 452652006645 acyl-activating enzyme (AAE) consensus motif; other site 452652006646 putative AMP binding site [chemical binding]; other site 452652006647 putative active site [active] 452652006648 putative CoA binding site [chemical binding]; other site 452652006649 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 452652006650 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 452652006651 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 452652006652 Major Facilitator Superfamily; Region: MFS_1; pfam07690 452652006653 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652006654 putative substrate translocation pore; other site 452652006655 hypothetical protein; Validated; Region: PRK06840 452652006656 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 452652006657 dimer interface [polypeptide binding]; other site 452652006658 active site 452652006659 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 452652006660 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 452652006661 dimer interface [polypeptide binding]; other site 452652006662 active site 452652006663 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 452652006664 Cytochrome P450; Region: p450; cl12078 452652006665 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 452652006666 DNA binding site [nucleotide binding] 452652006667 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 452652006668 seryl-tRNA synthetase; Provisional; Region: PRK05431 452652006669 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 452652006670 dimer interface [polypeptide binding]; other site 452652006671 active site 452652006672 motif 1; other site 452652006673 motif 2; other site 452652006674 motif 3; other site 452652006675 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 452652006676 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 452652006677 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 452652006678 dimer interface [polypeptide binding]; other site 452652006679 active site 452652006680 Phosphopantetheine attachment site; Region: PP-binding; cl09936 452652006681 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 452652006682 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 452652006683 dimer interface [polypeptide binding]; other site 452652006684 active site 452652006685 CoA binding pocket [chemical binding]; other site 452652006686 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 452652006687 dinuclear metal binding motif [ion binding]; other site 452652006688 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 452652006689 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 452652006690 hydrophobic ligand binding site; other site 452652006691 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 452652006692 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 452652006693 inhibitor-cofactor binding pocket; inhibition site 452652006694 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652006695 catalytic residue [active] 452652006696 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 452652006697 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 452652006698 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 452652006699 active site 452652006700 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 452652006701 NAD(P) binding site [chemical binding]; other site 452652006702 catalytic residues [active] 452652006703 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 452652006704 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 452652006705 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 452652006706 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 452652006707 Fatty acid desaturase; Region: FA_desaturase; pfam00487 452652006708 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 452652006709 putative di-iron ligands [ion binding]; other site 452652006710 benzoate transport; Region: 2A0115; TIGR00895 452652006711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652006712 putative substrate translocation pore; other site 452652006713 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 452652006714 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 452652006715 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 452652006716 putative TOMM peptide; Region: TOMM_nitrile_2; TIGR04351 452652006717 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 452652006718 YcaO-like family; Region: YcaO; pfam02624 452652006719 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 452652006720 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 452652006721 NADPH bind site [chemical binding]; other site 452652006722 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 452652006723 Histidine kinase; Region: HisKA_3; pfam07730 452652006724 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 452652006725 ATP binding site [chemical binding]; other site 452652006726 Mg2+ binding site [ion binding]; other site 452652006727 G-X-G motif; other site 452652006728 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652006729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652006730 active site 452652006731 phosphorylation site [posttranslational modification] 452652006732 intermolecular recognition site; other site 452652006733 dimerization interface [polypeptide binding]; other site 452652006734 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652006735 DNA binding residues [nucleotide binding] 452652006736 dimerization interface [polypeptide binding]; other site 452652006737 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 452652006738 Phosphopantetheine attachment site; Region: PP-binding; cl09936 452652006739 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 452652006740 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 452652006741 active site 452652006742 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 452652006743 acyl-activating enzyme (AAE) consensus motif; other site 452652006744 active site 452652006745 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 452652006746 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 452652006747 putative active site [active] 452652006748 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 452652006749 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 452652006750 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 452652006751 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 452652006752 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 452652006753 Domain interface; other site 452652006754 Peptide binding site; other site 452652006755 Active site tetrad [active] 452652006756 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 452652006757 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 452652006758 AsnC family; Region: AsnC_trans_reg; pfam01037 452652006759 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 452652006760 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 452652006761 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 452652006762 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 452652006763 nucleoside/Zn binding site; other site 452652006764 dimer interface [polypeptide binding]; other site 452652006765 catalytic motif [active] 452652006766 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 452652006767 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 452652006768 putative catalytic cysteine [active] 452652006769 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 452652006770 putative active site [active] 452652006771 metal binding site [ion binding]; metal-binding site 452652006772 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 452652006773 Pyruvate formate lyase 1; Region: PFL1; cd01678 452652006774 coenzyme A binding site [chemical binding]; other site 452652006775 active site 452652006776 catalytic residues [active] 452652006777 glycine loop; other site 452652006778 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 452652006779 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 452652006780 FeS/SAM binding site; other site 452652006781 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 452652006782 Phosphoesterase family; Region: Phosphoesterase; pfam04185 452652006783 Domain of unknown function (DUF756); Region: DUF756; pfam05506 452652006784 Domain of unknown function (DUF756); Region: DUF756; pfam05506 452652006785 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 452652006786 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 452652006787 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 452652006788 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 452652006789 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 452652006790 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 452652006791 Transglycosylase; Region: Transgly; pfam00912 452652006792 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 452652006793 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 452652006794 EamA-like transporter family; Region: EamA; pfam00892 452652006795 YCII-related domain; Region: YCII; cl00999 452652006796 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652006797 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652006798 active site 452652006799 phosphorylation site [posttranslational modification] 452652006800 intermolecular recognition site; other site 452652006801 dimerization interface [polypeptide binding]; other site 452652006802 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652006803 DNA binding residues [nucleotide binding] 452652006804 dimerization interface [polypeptide binding]; other site 452652006805 Histidine kinase; Region: HisKA_3; pfam07730 452652006806 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 452652006807 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 452652006808 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 452652006809 Walker A/P-loop; other site 452652006810 ATP binding site [chemical binding]; other site 452652006811 Q-loop/lid; other site 452652006812 ABC transporter signature motif; other site 452652006813 Walker B; other site 452652006814 D-loop; other site 452652006815 H-loop/switch region; other site 452652006816 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 452652006817 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 452652006818 Catalytic site [active] 452652006819 chorismate mutase; Provisional; Region: PRK09239 452652006820 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 452652006821 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452652006822 PAS domain; Region: PAS_9; pfam13426 452652006823 putative active site [active] 452652006824 heme pocket [chemical binding]; other site 452652006825 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 452652006826 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 452652006827 metal binding site [ion binding]; metal-binding site 452652006828 active site 452652006829 I-site; other site 452652006830 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 452652006831 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 452652006832 Phosphotransferase enzyme family; Region: APH; pfam01636 452652006833 active site 452652006834 substrate binding site [chemical binding]; other site 452652006835 ATP binding site [chemical binding]; other site 452652006836 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 452652006837 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 452652006838 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 452652006839 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 452652006840 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 452652006841 ligand binding site [chemical binding]; other site 452652006842 active site 452652006843 UGI interface [polypeptide binding]; other site 452652006844 catalytic site [active] 452652006845 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 452652006846 active site 452652006847 catalytic residues [active] 452652006848 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 452652006849 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 452652006850 active site 452652006851 motif I; other site 452652006852 motif II; other site 452652006853 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 452652006854 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 452652006855 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 452652006856 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 452652006857 NAD(P) binding site [chemical binding]; other site 452652006858 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 452652006859 Chitin binding domain; Region: Chitin_bind_3; pfam03067 452652006860 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 452652006861 putative oxidoreductase; Provisional; Region: PRK11579 452652006862 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 452652006863 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 452652006864 adenosine deaminase; Provisional; Region: PRK09358 452652006865 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 452652006866 active site 452652006867 Protein of unknown function (DUF445); Region: DUF445; pfam04286 452652006868 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 452652006869 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 452652006870 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 452652006871 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 452652006872 active site 452652006873 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 452652006874 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652006875 Walker A/P-loop; other site 452652006876 ATP binding site [chemical binding]; other site 452652006877 Q-loop/lid; other site 452652006878 ABC transporter signature motif; other site 452652006879 Walker B; other site 452652006880 D-loop; other site 452652006881 H-loop/switch region; other site 452652006882 ABC-2 family transporter protein; Region: ABC2_membrane_6; pfam06182 452652006883 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 452652006884 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 452652006885 oligomerisation interface [polypeptide binding]; other site 452652006886 mobile loop; other site 452652006887 roof hairpin; other site 452652006888 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 452652006889 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 452652006890 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 452652006891 catalytic triad [active] 452652006892 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 452652006893 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 452652006894 active site 452652006895 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 452652006896 Chitinase C; Region: ChiC; pfam06483 452652006897 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 452652006898 aromatic chitin/cellulose binding site residues [chemical binding]; other site 452652006899 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 452652006900 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 452652006901 Interdomain contacts; other site 452652006902 Cytokine receptor motif; other site 452652006903 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 452652006904 Glyco_18 domain; Region: Glyco_18; smart00636 452652006905 active site 452652006906 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 452652006907 active site 452652006908 dimerization interface [polypeptide binding]; other site 452652006909 ribonuclease PH; Reviewed; Region: rph; PRK00173 452652006910 Ribonuclease PH; Region: RNase_PH_bact; cd11362 452652006911 hexamer interface [polypeptide binding]; other site 452652006912 active site 452652006913 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 452652006914 active site turn [active] 452652006915 phosphorylation site [posttranslational modification] 452652006916 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 452652006917 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 452652006918 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 452652006919 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 452652006920 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652006921 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652006922 DNA binding residues [nucleotide binding] 452652006923 dimerization interface [polypeptide binding]; other site 452652006924 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 452652006925 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 452652006926 homodimer interface [polypeptide binding]; other site 452652006927 substrate-cofactor binding pocket; other site 452652006928 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652006929 catalytic residue [active] 452652006930 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 452652006931 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 452652006932 DNA binding residues [nucleotide binding] 452652006933 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 452652006934 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 452652006935 dimer interface [polypeptide binding]; other site 452652006936 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652006937 catalytic residue [active] 452652006938 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 452652006939 MoaE interaction surface [polypeptide binding]; other site 452652006940 MoeB interaction surface [polypeptide binding]; other site 452652006941 thiocarboxylated glycine; other site 452652006942 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 452652006943 MPN+ (JAMM) motif; other site 452652006944 Zinc-binding site [ion binding]; other site 452652006945 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 452652006946 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 452652006947 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 452652006948 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 452652006949 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 452652006950 active site 452652006951 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 452652006952 Isochorismatase family; Region: Isochorismatase; pfam00857 452652006953 catalytic triad [active] 452652006954 metal binding site [ion binding]; metal-binding site 452652006955 conserved cis-peptide bond; other site 452652006956 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 452652006957 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 452652006958 Cation efflux family; Region: Cation_efflux; cl00316 452652006959 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 452652006960 DinB superfamily; Region: DinB_2; pfam12867 452652006961 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 452652006962 nucleotide binding site/active site [active] 452652006963 HIT family signature motif; other site 452652006964 catalytic residue [active] 452652006965 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 452652006966 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 452652006967 active site 452652006968 catalytic residues [active] 452652006969 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 452652006970 Active_site [active] 452652006971 RDD family; Region: RDD; pfam06271 452652006972 RDD family; Region: RDD; pfam06271 452652006973 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 452652006974 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 452652006975 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452652006976 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 452652006977 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 452652006978 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 452652006979 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652006980 active site 452652006981 phosphorylation site [posttranslational modification] 452652006982 intermolecular recognition site; other site 452652006983 dimerization interface [polypeptide binding]; other site 452652006984 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 452652006985 DNA binding site [nucleotide binding] 452652006986 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 452652006987 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 452652006988 AsnC family; Region: AsnC_trans_reg; pfam01037 452652006989 Transcriptional regulator [Transcription]; Region: IclR; COG1414 452652006990 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 452652006991 Bacterial transcriptional regulator; Region: IclR; pfam01614 452652006992 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 452652006993 Transcriptional regulator [Transcription]; Region: IclR; COG1414 452652006994 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 452652006995 putative DNA binding site [nucleotide binding]; other site 452652006996 putative Zn2+ binding site [ion binding]; other site 452652006997 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 452652006998 TM2 domain; Region: TM2; pfam05154 452652006999 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 452652007000 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 452652007001 ATP binding site [chemical binding]; other site 452652007002 putative Mg++ binding site [ion binding]; other site 452652007003 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 452652007004 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652007005 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452652007006 DNA binding residues [nucleotide binding] 452652007007 Cellulose binding domain; Region: CBM_2; pfam00553 452652007008 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 452652007009 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 452652007010 active site 452652007011 putative catalytic site [active] 452652007012 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 452652007013 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 452652007014 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652007015 Major Facilitator Superfamily; Region: MFS_1; pfam07690 452652007016 putative substrate translocation pore; other site 452652007017 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 452652007018 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 452652007019 active site 452652007020 catalytic residues [active] 452652007021 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 452652007022 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 452652007023 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 452652007024 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 452652007025 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 452652007026 xanthine dehydrogenase E subunit; Region: pucE; TIGR03198 452652007027 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 452652007028 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 452652007029 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 452652007030 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 452652007031 active site 452652007032 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 452652007033 hypothetical protein; Validated; Region: PRK00228 452652007034 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 452652007035 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 452652007036 hinge; other site 452652007037 active site 452652007038 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 452652007039 IHF - DNA interface [nucleotide binding]; other site 452652007040 IHF dimer interface [polypeptide binding]; other site 452652007041 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 452652007042 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 452652007043 Malic enzyme, N-terminal domain; Region: malic; pfam00390 452652007044 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 452652007045 putative NAD(P) binding site [chemical binding]; other site 452652007046 PhoH-like protein; Region: PhoH; cl17668 452652007047 Family description; Region: UvrD_C_2; pfam13538 452652007048 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 452652007049 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 452652007050 active site 452652007051 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 452652007052 DNA binding site [nucleotide binding] 452652007053 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 452652007054 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 452652007055 SmpB-tmRNA interface; other site 452652007056 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 452652007057 protein binding site [polypeptide binding]; other site 452652007058 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 452652007059 Catalytic dyad [active] 452652007060 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 452652007061 FtsX-like permease family; Region: FtsX; pfam02687 452652007062 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 452652007063 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652007064 Walker A/P-loop; other site 452652007065 ATP binding site [chemical binding]; other site 452652007066 Q-loop/lid; other site 452652007067 ABC transporter signature motif; other site 452652007068 Walker B; other site 452652007069 D-loop; other site 452652007070 H-loop/switch region; other site 452652007071 peptide chain release factor 2; Validated; Region: prfB; PRK00578 452652007072 This domain is found in peptide chain release factors; Region: PCRF; smart00937 452652007073 RF-1 domain; Region: RF-1; pfam00472 452652007074 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 452652007075 Catalytic domain of Protein Kinases; Region: PKc; cd00180 452652007076 active site 452652007077 ATP binding site [chemical binding]; other site 452652007078 substrate binding site [chemical binding]; other site 452652007079 activation loop (A-loop); other site 452652007080 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 452652007081 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 452652007082 active site 452652007083 ATP binding site [chemical binding]; other site 452652007084 substrate binding site [chemical binding]; other site 452652007085 activation loop (A-loop); other site 452652007086 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 452652007087 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 452652007088 phosphopeptide binding site; other site 452652007089 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 452652007090 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 452652007091 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 452652007092 NAD(P) binding site [chemical binding]; other site 452652007093 catalytic residues [active] 452652007094 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 452652007095 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 452652007096 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 452652007097 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 452652007098 active site 452652007099 catalytic tetrad [active] 452652007100 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 452652007101 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652007102 H+ Antiporter protein; Region: 2A0121; TIGR00900 452652007103 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652007104 putative substrate translocation pore; other site 452652007105 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 452652007106 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 452652007107 catalytic triad [active] 452652007108 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 452652007109 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 452652007110 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 452652007111 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 452652007112 substrate binding pocket [chemical binding]; other site 452652007113 active site 452652007114 iron coordination sites [ion binding]; other site 452652007115 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 452652007116 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 452652007117 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 452652007118 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652007119 NAD(P) binding site [chemical binding]; other site 452652007120 active site 452652007121 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652007122 DNA binding residues [nucleotide binding] 452652007123 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652007124 dimerization interface [polypeptide binding]; other site 452652007125 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 452652007126 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 452652007127 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 452652007128 nucleotide binding region [chemical binding]; other site 452652007129 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 452652007130 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 452652007131 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652007132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652007133 active site 452652007134 phosphorylation site [posttranslational modification] 452652007135 intermolecular recognition site; other site 452652007136 dimerization interface [polypeptide binding]; other site 452652007137 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652007138 DNA binding residues [nucleotide binding] 452652007139 dimerization interface [polypeptide binding]; other site 452652007140 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 452652007141 30S subunit binding site; other site 452652007142 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 452652007143 lipoprotein LpqB; Provisional; Region: PRK13613 452652007144 Sporulation and spore germination; Region: Germane; pfam10646 452652007145 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452652007146 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 452652007147 dimerization interface [polypeptide binding]; other site 452652007148 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452652007149 dimer interface [polypeptide binding]; other site 452652007150 phosphorylation site [posttranslational modification] 452652007151 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652007152 ATP binding site [chemical binding]; other site 452652007153 Mg2+ binding site [ion binding]; other site 452652007154 G-X-G motif; other site 452652007155 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 452652007156 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652007157 active site 452652007158 phosphorylation site [posttranslational modification] 452652007159 intermolecular recognition site; other site 452652007160 dimerization interface [polypeptide binding]; other site 452652007161 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 452652007162 DNA binding site [nucleotide binding] 452652007163 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 452652007164 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 452652007165 MoxR-like ATPases [General function prediction only]; Region: COG0714 452652007166 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452652007167 Walker A motif; other site 452652007168 ATP binding site [chemical binding]; other site 452652007169 Walker B motif; other site 452652007170 arginine finger; other site 452652007171 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 452652007172 Protein of unknown function DUF58; Region: DUF58; pfam01882 452652007173 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 452652007174 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 452652007175 Integral membrane protein DUF95; Region: DUF95; pfam01944 452652007176 Predicted membrane protein/domain [Function unknown]; Region: COG1714 452652007177 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 452652007178 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652007179 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452652007180 DNA binding residues [nucleotide binding] 452652007181 Adenosylhomocysteinase; Provisional; Region: PTZ00075 452652007182 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 452652007183 homotetramer interface [polypeptide binding]; other site 452652007184 ligand binding site [chemical binding]; other site 452652007185 catalytic site [active] 452652007186 NAD binding site [chemical binding]; other site 452652007187 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 452652007188 Cation efflux family; Region: Cation_efflux; pfam01545 452652007189 Trm112p-like protein; Region: Trm112p; cl01066 452652007190 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 452652007191 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 452652007192 active site 452652007193 substrate binding site [chemical binding]; other site 452652007194 metal binding site [ion binding]; metal-binding site 452652007195 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 452652007196 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 452652007197 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 452652007198 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 452652007199 active site 452652007200 Transcription factor WhiB; Region: Whib; pfam02467 452652007201 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 452652007202 LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606 452652007203 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 452652007204 phosphate binding site [ion binding]; other site 452652007205 dimer interface [polypeptide binding]; other site 452652007206 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 452652007207 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 452652007208 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 452652007209 putative FMN binding site [chemical binding]; other site 452652007210 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 452652007211 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 452652007212 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 452652007213 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 452652007214 helix-hairpin-helix signature motif; other site 452652007215 active site 452652007216 TIGR03089 family protein; Region: TIGR03089 452652007217 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 452652007218 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 452652007219 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 452652007220 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 452652007221 putative trimer interface [polypeptide binding]; other site 452652007222 putative active site [active] 452652007223 putative substrate binding site [chemical binding]; other site 452652007224 putative CoA binding site [chemical binding]; other site 452652007225 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 452652007226 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 452652007227 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452652007228 FtsX-like permease family; Region: FtsX; pfam02687 452652007229 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452652007230 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 452652007231 FtsX-like permease family; Region: FtsX; pfam02687 452652007232 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 452652007233 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 452652007234 Walker A/P-loop; other site 452652007235 ATP binding site [chemical binding]; other site 452652007236 Q-loop/lid; other site 452652007237 ABC transporter signature motif; other site 452652007238 Walker B; other site 452652007239 D-loop; other site 452652007240 H-loop/switch region; other site 452652007241 FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567 452652007242 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 452652007243 Transcriptional regulator [Transcription]; Region: LytR; COG1316 452652007244 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 452652007245 trimer interface [polypeptide binding]; other site 452652007246 active site 452652007247 substrate binding site [chemical binding]; other site 452652007248 CoA binding site [chemical binding]; other site 452652007249 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 452652007250 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 452652007251 active site 452652007252 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 452652007253 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 452652007254 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 452652007255 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 452652007256 CoA binding domain; Region: CoA_binding; cl17356 452652007257 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 452652007258 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 452652007259 DNA binding residues [nucleotide binding] 452652007260 drug binding residues [chemical binding]; other site 452652007261 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 452652007262 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 452652007263 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 452652007264 active site 452652007265 dimer interface [polypeptide binding]; other site 452652007266 AIR carboxylase; Region: AIRC; pfam00731 452652007267 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 452652007268 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 452652007269 NAD binding site [chemical binding]; other site 452652007270 ATP-grasp domain; Region: ATP-grasp; pfam02222 452652007271 GtrA-like protein; Region: GtrA; pfam04138 452652007272 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452652007273 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452652007274 dimer interface [polypeptide binding]; other site 452652007275 phosphorylation site [posttranslational modification] 452652007276 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652007277 ATP binding site [chemical binding]; other site 452652007278 Mg2+ binding site [ion binding]; other site 452652007279 G-X-G motif; other site 452652007280 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 452652007281 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652007282 active site 452652007283 phosphorylation site [posttranslational modification] 452652007284 intermolecular recognition site; other site 452652007285 dimerization interface [polypeptide binding]; other site 452652007286 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 452652007287 DNA binding site [nucleotide binding] 452652007288 imidazolonepropionase; Provisional; Region: PRK14085 452652007289 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 452652007290 active site 452652007291 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 452652007292 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 452652007293 active site 452652007294 allantoate amidohydrolase; Reviewed; Region: PRK09290 452652007295 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 452652007296 active site 452652007297 metal binding site [ion binding]; metal-binding site 452652007298 dimer interface [polypeptide binding]; other site 452652007299 urocanate hydratase; Provisional; Region: PRK05414 452652007300 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 452652007301 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 452652007302 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 452652007303 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 452652007304 active sites [active] 452652007305 tetramer interface [polypeptide binding]; other site 452652007306 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 452652007307 GAF domain; Region: GAF; cl17456 452652007308 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 452652007309 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 452652007310 metal binding site [ion binding]; metal-binding site 452652007311 active site 452652007312 I-site; other site 452652007313 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 452652007314 cyclase homology domain; Region: CHD; cd07302 452652007315 nucleotidyl binding site; other site 452652007316 metal binding site [ion binding]; metal-binding site 452652007317 dimer interface [polypeptide binding]; other site 452652007318 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 452652007319 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 452652007320 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 452652007321 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 452652007322 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 452652007323 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 452652007324 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 452652007325 Maf-like protein; Region: Maf; pfam02545 452652007326 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 452652007327 active site 452652007328 dimer interface [polypeptide binding]; other site 452652007329 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 452652007330 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 452652007331 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 452652007332 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 452652007333 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 452652007334 carboxyltransferase (CT) interaction site; other site 452652007335 biotinylation site [posttranslational modification]; other site 452652007336 peptide synthase; Provisional; Region: PRK12467 452652007337 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 452652007338 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 452652007339 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 452652007340 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 452652007341 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 452652007342 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 452652007343 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 452652007344 putative active site pocket [active] 452652007345 dimerization interface [polypeptide binding]; other site 452652007346 putative catalytic residue [active] 452652007347 purine nucleoside phosphorylase; Provisional; Region: PRK08202 452652007348 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 452652007349 active site 452652007350 substrate binding site [chemical binding]; other site 452652007351 metal binding site [ion binding]; metal-binding site 452652007352 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 452652007353 Domain of unknown function (DUF1851); Region: DUF1851; pfam08906 452652007354 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 452652007355 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 452652007356 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 452652007357 protein-splicing catalytic site; other site 452652007358 thioester formation/cholesterol transfer; other site 452652007359 Pretoxin HINT domain; Region: PT-HINT; pfam07591 452652007360 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 452652007361 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 452652007362 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 452652007363 putative sugar binding sites [chemical binding]; other site 452652007364 Q-X-W motif; other site 452652007365 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 452652007366 dimerization interface [polypeptide binding]; other site 452652007367 putative DNA binding site [nucleotide binding]; other site 452652007368 putative Zn2+ binding site [ion binding]; other site 452652007369 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 452652007370 NAD(P) binding site [chemical binding]; other site 452652007371 Predicted transcriptional regulators [Transcription]; Region: COG1733 452652007372 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 452652007373 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 452652007374 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 452652007375 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 452652007376 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 452652007377 Walker A/P-loop; other site 452652007378 ATP binding site [chemical binding]; other site 452652007379 Q-loop/lid; other site 452652007380 ABC transporter signature motif; other site 452652007381 Walker B; other site 452652007382 D-loop; other site 452652007383 H-loop/switch region; other site 452652007384 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 452652007385 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 452652007386 active site 452652007387 HIGH motif; other site 452652007388 KMSKS motif; other site 452652007389 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 452652007390 tRNA binding surface [nucleotide binding]; other site 452652007391 anticodon binding site; other site 452652007392 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652007393 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 452652007394 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652007395 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452652007396 DNA binding residues [nucleotide binding] 452652007397 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 452652007398 intersubunit interface [polypeptide binding]; other site 452652007399 active site 452652007400 catalytic residue [active] 452652007401 Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111 452652007402 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 452652007403 NAD(P) binding site [chemical binding]; other site 452652007404 catalytic residues [active] 452652007405 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 452652007406 NAD(P) binding site [chemical binding]; other site 452652007407 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 452652007408 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652007409 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452652007410 DNA binding residues [nucleotide binding] 452652007411 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 452652007412 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652007413 active site 452652007414 phosphorylation site [posttranslational modification] 452652007415 intermolecular recognition site; other site 452652007416 dimerization interface [polypeptide binding]; other site 452652007417 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 452652007418 DNA binding site [nucleotide binding] 452652007419 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452652007420 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 452652007421 dimerization interface [polypeptide binding]; other site 452652007422 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452652007423 dimer interface [polypeptide binding]; other site 452652007424 phosphorylation site [posttranslational modification] 452652007425 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652007426 ATP binding site [chemical binding]; other site 452652007427 Mg2+ binding site [ion binding]; other site 452652007428 G-X-G motif; other site 452652007429 PspC domain; Region: PspC; pfam04024 452652007430 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 452652007431 adenosine deaminase; Provisional; Region: PRK09358 452652007432 active site 452652007433 Transcriptional regulator [Transcription]; Region: LysR; COG0583 452652007434 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 452652007435 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 452652007436 putative dimerization interface [polypeptide binding]; other site 452652007437 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 452652007438 putative active site [active] 452652007439 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652007440 non-specific DNA binding site [nucleotide binding]; other site 452652007441 salt bridge; other site 452652007442 sequence-specific DNA binding site [nucleotide binding]; other site 452652007443 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 452652007444 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 452652007445 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 452652007446 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 452652007447 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 452652007448 active site 452652007449 catalytic motif [active] 452652007450 Zn binding site [ion binding]; other site 452652007451 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 452652007452 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 452652007453 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 452652007454 TM-ABC transporter signature motif; other site 452652007455 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 452652007456 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 452652007457 TM-ABC transporter signature motif; other site 452652007458 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 452652007459 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 452652007460 Walker A/P-loop; other site 452652007461 ATP binding site [chemical binding]; other site 452652007462 Q-loop/lid; other site 452652007463 ABC transporter signature motif; other site 452652007464 Walker B; other site 452652007465 D-loop; other site 452652007466 H-loop/switch region; other site 452652007467 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 452652007468 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 452652007469 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 452652007470 ligand binding site [chemical binding]; other site 452652007471 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 452652007472 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 452652007473 metal binding site [ion binding]; metal-binding site 452652007474 putative dimer interface [polypeptide binding]; other site 452652007475 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 452652007476 peptidase domain interface [polypeptide binding]; other site 452652007477 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 452652007478 active site 452652007479 catalytic triad [active] 452652007480 calcium binding site [ion binding]; other site 452652007481 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 452652007482 malonic semialdehyde reductase; Provisional; Region: PRK10538 452652007483 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652007484 NAD(P) binding site [chemical binding]; other site 452652007485 active site 452652007486 putative OHCU decarboxylase; Provisional; Region: PRK13798 452652007487 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 452652007488 putative Iron-sulfur protein interface [polypeptide binding]; other site 452652007489 putative proximal heme binding site [chemical binding]; other site 452652007490 putative SdhD-like interface [polypeptide binding]; other site 452652007491 putative distal heme binding site [chemical binding]; other site 452652007492 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 452652007493 putative Iron-sulfur protein interface [polypeptide binding]; other site 452652007494 putative proximal heme binding site [chemical binding]; other site 452652007495 putative SdhC-like subunit interface [polypeptide binding]; other site 452652007496 putative distal heme binding site [chemical binding]; other site 452652007497 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 452652007498 L-aspartate oxidase; Provisional; Region: PRK06175 452652007499 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 452652007500 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 452652007501 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 452652007502 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 452652007503 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 452652007504 Methyltransferase domain; Region: Methyltransf_24; pfam13578 452652007505 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 452652007506 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 452652007507 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 452652007508 active site 452652007509 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 452652007510 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 452652007511 active site 452652007512 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 452652007513 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 452652007514 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 452652007515 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 452652007516 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 452652007517 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 452652007518 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 452652007519 active site 452652007520 HIGH motif; other site 452652007521 dimer interface [polypeptide binding]; other site 452652007522 KMSKS motif; other site 452652007523 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 452652007524 Domain of unknown function DUF21; Region: DUF21; pfam01595 452652007525 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 452652007526 Transporter associated domain; Region: CorC_HlyC; smart01091 452652007527 malate dehydrogenase; Provisional; Region: PRK05442 452652007528 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 452652007529 NAD(P) binding site [chemical binding]; other site 452652007530 dimer interface [polypeptide binding]; other site 452652007531 malate binding site [chemical binding]; other site 452652007532 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 452652007533 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 452652007534 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 452652007535 homodimer interface [polypeptide binding]; other site 452652007536 NADP binding site [chemical binding]; other site 452652007537 substrate binding site [chemical binding]; other site 452652007538 RDD family; Region: RDD; pfam06271 452652007539 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 452652007540 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 452652007541 purine monophosphate binding site [chemical binding]; other site 452652007542 dimer interface [polypeptide binding]; other site 452652007543 putative catalytic residues [active] 452652007544 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 452652007545 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 452652007546 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 452652007547 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 452652007548 active site 452652007549 substrate binding site [chemical binding]; other site 452652007550 cosubstrate binding site; other site 452652007551 catalytic site [active] 452652007552 Domain of unknown function (DUF397); Region: DUF397; pfam04149 452652007553 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652007554 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652007555 active site 452652007556 phosphorylation site [posttranslational modification] 452652007557 intermolecular recognition site; other site 452652007558 dimerization interface [polypeptide binding]; other site 452652007559 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652007560 DNA binding residues [nucleotide binding] 452652007561 dimerization interface [polypeptide binding]; other site 452652007562 Histidine kinase; Region: HisKA_3; pfam07730 452652007563 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 452652007564 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 452652007565 MarR family; Region: MarR_2; pfam12802 452652007566 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 452652007567 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652007568 NAD(P) binding site [chemical binding]; other site 452652007569 active site 452652007570 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652007571 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 452652007572 Walker A/P-loop; other site 452652007573 ATP binding site [chemical binding]; other site 452652007574 Q-loop/lid; other site 452652007575 ABC transporter signature motif; other site 452652007576 Walker B; other site 452652007577 D-loop; other site 452652007578 H-loop/switch region; other site 452652007579 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 452652007580 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 452652007581 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 452652007582 CoA binding domain; Region: CoA_binding; smart00881 452652007583 CoA-ligase; Region: Ligase_CoA; pfam00549 452652007584 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 452652007585 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 452652007586 CoA-ligase; Region: Ligase_CoA; pfam00549 452652007587 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 452652007588 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 452652007589 metal ion-dependent adhesion site (MIDAS); other site 452652007590 MoxR-like ATPases [General function prediction only]; Region: COG0714 452652007591 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 452652007592 SWIM zinc finger; Region: SWIM; pfam04434 452652007593 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 452652007594 B12 binding site [chemical binding]; other site 452652007595 cobalt ligand [ion binding]; other site 452652007596 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 452652007597 Part of AAA domain; Region: AAA_19; pfam13245 452652007598 Family description; Region: UvrD_C_2; pfam13538 452652007599 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652007600 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652007601 active site 452652007602 phosphorylation site [posttranslational modification] 452652007603 intermolecular recognition site; other site 452652007604 dimerization interface [polypeptide binding]; other site 452652007605 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652007606 DNA binding residues [nucleotide binding] 452652007607 dimerization interface [polypeptide binding]; other site 452652007608 PspC domain; Region: PspC; pfam04024 452652007609 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 452652007610 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652007611 ATP binding site [chemical binding]; other site 452652007612 Mg2+ binding site [ion binding]; other site 452652007613 G-X-G motif; other site 452652007614 PspC domain; Region: PspC; pfam04024 452652007615 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 452652007616 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 452652007617 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 452652007618 iron-sulfur cluster [ion binding]; other site 452652007619 [2Fe-2S] cluster binding site [ion binding]; other site 452652007620 GMP synthase; Reviewed; Region: guaA; PRK00074 452652007621 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 452652007622 AMP/PPi binding site [chemical binding]; other site 452652007623 candidate oxyanion hole; other site 452652007624 catalytic triad [active] 452652007625 potential glutamine specificity residues [chemical binding]; other site 452652007626 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 452652007627 ATP Binding subdomain [chemical binding]; other site 452652007628 Ligand Binding sites [chemical binding]; other site 452652007629 Dimerization subdomain; other site 452652007630 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 452652007631 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 452652007632 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 452652007633 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 452652007634 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 452652007635 NAD(P) binding site [chemical binding]; other site 452652007636 catalytic residues [active] 452652007637 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 452652007638 Catalytic domain of Protein Kinases; Region: PKc; cd00180 452652007639 active site 452652007640 ATP binding site [chemical binding]; other site 452652007641 substrate binding site [chemical binding]; other site 452652007642 activation loop (A-loop); other site 452652007643 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 452652007644 substrate binding site [chemical binding]; other site 452652007645 activation loop (A-loop); other site 452652007646 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 452652007647 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 452652007648 active site 452652007649 ATP binding site [chemical binding]; other site 452652007650 substrate binding site [chemical binding]; other site 452652007651 activation loop (A-loop); other site 452652007652 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 452652007653 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 452652007654 active site 452652007655 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 452652007656 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 452652007657 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 452652007658 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 452652007659 active site 452652007660 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 452652007661 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652007662 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452652007663 DNA binding residues [nucleotide binding] 452652007664 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652007665 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652007666 active site 452652007667 phosphorylation site [posttranslational modification] 452652007668 intermolecular recognition site; other site 452652007669 dimerization interface [polypeptide binding]; other site 452652007670 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652007671 DNA binding residues [nucleotide binding] 452652007672 dimerization interface [polypeptide binding]; other site 452652007673 Transcription factor WhiB; Region: Whib; pfam02467 452652007674 Transcriptional regulator [Transcription]; Region: LysR; COG0583 452652007675 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 452652007676 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 452652007677 putative dimerization interface [polypeptide binding]; other site 452652007678 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 452652007679 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 452652007680 ring oligomerisation interface [polypeptide binding]; other site 452652007681 ATP/Mg binding site [chemical binding]; other site 452652007682 stacking interactions; other site 452652007683 hinge regions; other site 452652007684 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 452652007685 oligomerisation interface [polypeptide binding]; other site 452652007686 mobile loop; other site 452652007687 roof hairpin; other site 452652007688 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 452652007689 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 452652007690 NodB motif; other site 452652007691 active site 452652007692 catalytic site [active] 452652007693 metal binding site [ion binding]; metal-binding site 452652007694 tRNA threonylcarbamoyl adenosine modification protein YgjD; Region: T6A_YgjD; TIGR03723 452652007695 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 452652007696 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 452652007697 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 452652007698 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 452652007699 Glycoprotease family; Region: Peptidase_M22; pfam00814 452652007700 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 452652007701 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 452652007702 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 452652007703 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 452652007704 TAP-like protein; Region: Abhydrolase_4; pfam08386 452652007705 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 452652007706 alanine racemase; Reviewed; Region: alr; PRK00053 452652007707 active site 452652007708 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 452652007709 dimer interface [polypeptide binding]; other site 452652007710 substrate binding site [chemical binding]; other site 452652007711 catalytic residues [active] 452652007712 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 452652007713 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 452652007714 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 452652007715 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 452652007716 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 452652007717 glutaminase active site [active] 452652007718 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 452652007719 dimer interface [polypeptide binding]; other site 452652007720 active site 452652007721 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 452652007722 dimer interface [polypeptide binding]; other site 452652007723 active site 452652007724 pantothenate kinase; Provisional; Region: PRK05439 452652007725 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 452652007726 ATP-binding site [chemical binding]; other site 452652007727 CoA-binding site [chemical binding]; other site 452652007728 Mg2+-binding site [ion binding]; other site 452652007729 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 452652007730 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 452652007731 active site 452652007732 substrate binding site [chemical binding]; other site 452652007733 metal binding site [ion binding]; metal-binding site 452652007734 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 452652007735 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 452652007736 23S rRNA interface [nucleotide binding]; other site 452652007737 L3 interface [polypeptide binding]; other site 452652007738 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 452652007739 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652007740 Walker A/P-loop; other site 452652007741 ATP binding site [chemical binding]; other site 452652007742 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 452652007743 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 452652007744 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 452652007745 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 452652007746 dimerization interface 3.5A [polypeptide binding]; other site 452652007747 active site 452652007748 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 452652007749 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 452652007750 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 452652007751 alphaNTD homodimer interface [polypeptide binding]; other site 452652007752 alphaNTD - beta interaction site [polypeptide binding]; other site 452652007753 alphaNTD - beta' interaction site [polypeptide binding]; other site 452652007754 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 452652007755 30S ribosomal protein S11; Validated; Region: PRK05309 452652007756 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 452652007757 30S ribosomal protein S13; Region: bact_S13; TIGR03631 452652007758 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 452652007759 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 452652007760 rRNA binding site [nucleotide binding]; other site 452652007761 predicted 30S ribosome binding site; other site 452652007762 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 452652007763 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 452652007764 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 452652007765 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 452652007766 active site 452652007767 adenylate kinase; Reviewed; Region: adk; PRK00279 452652007768 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 452652007769 AMP-binding site [chemical binding]; other site 452652007770 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 452652007771 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 452652007772 SecY translocase; Region: SecY; pfam00344 452652007773 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 452652007774 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 452652007775 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 452652007776 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 452652007777 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 452652007778 putative ADP-binding pocket [chemical binding]; other site 452652007779 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 452652007780 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 452652007781 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 452652007782 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 452652007783 23S rRNA binding site [nucleotide binding]; other site 452652007784 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 452652007785 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 452652007786 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 452652007787 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 452652007788 5S rRNA interface [nucleotide binding]; other site 452652007789 23S rRNA interface [nucleotide binding]; other site 452652007790 L5 interface [polypeptide binding]; other site 452652007791 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 452652007792 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 452652007793 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 452652007794 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 452652007795 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 452652007796 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 452652007797 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 452652007798 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 452652007799 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 452652007800 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 452652007801 RNA binding site [nucleotide binding]; other site 452652007802 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 452652007803 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 452652007804 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 452652007805 23S rRNA interface [nucleotide binding]; other site 452652007806 putative translocon interaction site; other site 452652007807 signal recognition particle (SRP54) interaction site; other site 452652007808 L23 interface [polypeptide binding]; other site 452652007809 trigger factor interaction site; other site 452652007810 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 452652007811 23S rRNA interface [nucleotide binding]; other site 452652007812 5S rRNA interface [nucleotide binding]; other site 452652007813 putative antibiotic binding site [chemical binding]; other site 452652007814 L25 interface [polypeptide binding]; other site 452652007815 L27 interface [polypeptide binding]; other site 452652007816 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 452652007817 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 452652007818 G-X-X-G motif; other site 452652007819 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 452652007820 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 452652007821 putative translocon binding site; other site 452652007822 protein-rRNA interface [nucleotide binding]; other site 452652007823 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 452652007824 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 452652007825 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 452652007826 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 452652007827 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 452652007828 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 452652007829 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 452652007830 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 452652007831 Uncharacterized membrane protein, required for N-linked glycosylation [General function prediction only]; Region: COG1287 452652007832 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 452652007833 active site 452652007834 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 452652007835 Uncharacterized conserved protein (DUF2304); Region: DUF2304; pfam10066 452652007836 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 452652007837 Ligand binding site; other site 452652007838 Putative Catalytic site; other site 452652007839 DXD motif; other site 452652007840 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 452652007841 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 452652007842 NADP binding site [chemical binding]; other site 452652007843 active site 452652007844 putative substrate binding site [chemical binding]; other site 452652007845 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 452652007846 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 452652007847 NAD binding site [chemical binding]; other site 452652007848 substrate binding site [chemical binding]; other site 452652007849 homodimer interface [polypeptide binding]; other site 452652007850 active site 452652007851 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 452652007852 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 452652007853 substrate binding site; other site 452652007854 tetramer interface; other site 452652007855 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 452652007856 Predicted membrane protein [Function unknown]; Region: COG2246 452652007857 GtrA-like protein; Region: GtrA; pfam04138 452652007858 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 452652007859 elongation factor Tu; Reviewed; Region: PRK00049 452652007860 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 452652007861 G1 box; other site 452652007862 GEF interaction site [polypeptide binding]; other site 452652007863 GTP/Mg2+ binding site [chemical binding]; other site 452652007864 Switch I region; other site 452652007865 G2 box; other site 452652007866 G3 box; other site 452652007867 Switch II region; other site 452652007868 G4 box; other site 452652007869 G5 box; other site 452652007870 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 452652007871 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 452652007872 Antibiotic Binding Site [chemical binding]; other site 452652007873 elongation factor G; Reviewed; Region: PRK00007 452652007874 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 452652007875 G1 box; other site 452652007876 putative GEF interaction site [polypeptide binding]; other site 452652007877 GTP/Mg2+ binding site [chemical binding]; other site 452652007878 Switch I region; other site 452652007879 G2 box; other site 452652007880 G3 box; other site 452652007881 Switch II region; other site 452652007882 G4 box; other site 452652007883 G5 box; other site 452652007884 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 452652007885 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 452652007886 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 452652007887 30S ribosomal protein S7; Validated; Region: PRK05302 452652007888 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 452652007889 S17 interaction site [polypeptide binding]; other site 452652007890 S8 interaction site; other site 452652007891 16S rRNA interaction site [nucleotide binding]; other site 452652007892 streptomycin interaction site [chemical binding]; other site 452652007893 23S rRNA interaction site [nucleotide binding]; other site 452652007894 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 452652007895 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 452652007896 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 452652007897 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 452652007898 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 452652007899 Walker A/P-loop; other site 452652007900 ATP binding site [chemical binding]; other site 452652007901 Q-loop/lid; other site 452652007902 ABC transporter signature motif; other site 452652007903 Walker B; other site 452652007904 D-loop; other site 452652007905 H-loop/switch region; other site 452652007906 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 452652007907 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 452652007908 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 452652007909 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 452652007910 NAD-dependent deacetylase; Provisional; Region: PRK00481 452652007911 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652007912 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652007913 active site 452652007914 phosphorylation site [posttranslational modification] 452652007915 intermolecular recognition site; other site 452652007916 dimerization interface [polypeptide binding]; other site 452652007917 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652007918 DNA binding residues [nucleotide binding] 452652007919 dimerization interface [polypeptide binding]; other site 452652007920 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 452652007921 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 452652007922 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 452652007923 active site 452652007924 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 452652007925 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 452652007926 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 452652007927 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 452652007928 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 452652007929 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 452652007930 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 452652007931 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 452652007932 G-loop; other site 452652007933 DNA binding site [nucleotide binding] 452652007934 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 452652007935 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 452652007936 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 452652007937 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 452652007938 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 452652007939 RPB10 interaction site [polypeptide binding]; other site 452652007940 RPB1 interaction site [polypeptide binding]; other site 452652007941 RPB11 interaction site [polypeptide binding]; other site 452652007942 RPB3 interaction site [polypeptide binding]; other site 452652007943 RPB12 interaction site [polypeptide binding]; other site 452652007944 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 452652007945 core dimer interface [polypeptide binding]; other site 452652007946 peripheral dimer interface [polypeptide binding]; other site 452652007947 L10 interface [polypeptide binding]; other site 452652007948 L11 interface [polypeptide binding]; other site 452652007949 putative EF-Tu interaction site [polypeptide binding]; other site 452652007950 putative EF-G interaction site [polypeptide binding]; other site 452652007951 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 452652007952 23S rRNA interface [nucleotide binding]; other site 452652007953 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 452652007954 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 452652007955 mRNA/rRNA interface [nucleotide binding]; other site 452652007956 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 452652007957 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 452652007958 23S rRNA interface [nucleotide binding]; other site 452652007959 L7/L12 interface [polypeptide binding]; other site 452652007960 putative thiostrepton binding site; other site 452652007961 L25 interface [polypeptide binding]; other site 452652007962 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 452652007963 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 452652007964 putative homodimer interface [polypeptide binding]; other site 452652007965 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 452652007966 heterodimer interface [polypeptide binding]; other site 452652007967 homodimer interface [polypeptide binding]; other site 452652007968 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 452652007969 aspartate aminotransferase; Provisional; Region: PRK05764 452652007970 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 452652007971 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652007972 homodimer interface [polypeptide binding]; other site 452652007973 catalytic residue [active] 452652007974 adenosine deaminase; Provisional; Region: PRK09358 452652007975 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 452652007976 active site 452652007977 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 452652007978 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 452652007979 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 452652007980 FAD binding domain; Region: FAD_binding_4; pfam01565 452652007981 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 452652007982 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 452652007983 Domain of unknown function (DUF3291); Region: DUF3291; pfam11695 452652007984 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652007985 putative substrate translocation pore; other site 452652007986 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652007987 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652007988 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652007989 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 452652007990 active site 452652007991 catalytic site [active] 452652007992 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 452652007993 active site 452652007994 catalytic site [active] 452652007995 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 452652007996 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 452652007997 active site 452652007998 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 452652007999 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 452652008000 putative transposase OrfB; Reviewed; Region: PHA02517 452652008001 HTH-like domain; Region: HTH_21; pfam13276 452652008002 Integrase core domain; Region: rve; pfam00665 452652008003 Integrase core domain; Region: rve_3; pfam13683 452652008004 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 452652008005 Transposase; Region: HTH_Tnp_1; pfam01527 452652008006 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 452652008007 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 452652008008 active site 452652008009 DNA binding site [nucleotide binding] 452652008010 Int/Topo IB signature motif; other site 452652008011 Helix-turn-helix domain; Region: HTH_17; pfam12728 452652008012 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 452652008013 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 452652008014 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 452652008015 Helix-turn-helix domain; Region: HTH_36; pfam13730 452652008016 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 452652008017 FAD binding domain; Region: FAD_binding_4; pfam01565 452652008018 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 452652008019 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 452652008020 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652008021 NAD(P) binding site [chemical binding]; other site 452652008022 active site 452652008023 Thymidylate synthase; Region: Thymidylat_synt; pfam00303 452652008024 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 452652008025 dimerization interface [polypeptide binding]; other site 452652008026 active site 452652008027 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 452652008028 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 452652008029 topology modulation protein; Reviewed; Region: PRK08118 452652008030 AAA domain; Region: AAA_17; pfam13207 452652008031 Methyltransferase domain; Region: Methyltransf_31; pfam13847 452652008032 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652008033 S-adenosylmethionine binding site [chemical binding]; other site 452652008034 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 452652008035 nudix motif; other site 452652008036 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 452652008037 nudix motif; other site 452652008038 hydrogenase membrane subunit; Validated; Region: PRK08667 452652008039 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 452652008040 active site 452652008041 Phosphotransferase enzyme family; Region: APH; pfam01636 452652008042 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 452652008043 substrate binding site [chemical binding]; other site 452652008044 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 452652008045 putative trimer interface [polypeptide binding]; other site 452652008046 putative CoA binding site [chemical binding]; other site 452652008047 hypothetical protein; Provisional; Region: PRK11770 452652008048 Domain of unknown function (DUF307); Region: DUF307; pfam03733 452652008049 Domain of unknown function (DUF307); Region: DUF307; pfam03733 452652008050 hypothetical protein; Provisional; Region: PRK11770 452652008051 Domain of unknown function (DUF307); Region: DUF307; pfam03733 452652008052 Domain of unknown function (DUF307); Region: DUF307; pfam03733 452652008053 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 452652008054 AAA domain; Region: AAA_12; pfam13087 452652008055 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 452652008056 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 452652008057 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 452652008058 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652008059 sequence-specific DNA binding site [nucleotide binding]; other site 452652008060 salt bridge; other site 452652008061 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 452652008062 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 452652008063 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 452652008064 Domain of unknown function (DUF397); Region: DUF397; pfam04149 452652008065 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 452652008066 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652008067 non-specific DNA binding site [nucleotide binding]; other site 452652008068 salt bridge; other site 452652008069 sequence-specific DNA binding site [nucleotide binding]; other site 452652008070 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 452652008071 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 452652008072 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 452652008073 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 452652008074 putative active site [active] 452652008075 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 452652008076 active site 452652008077 metal binding site [ion binding]; metal-binding site 452652008078 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 452652008079 trimer interface [polypeptide binding]; other site 452652008080 active site 452652008081 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 452652008082 trimer interface [polypeptide binding]; other site 452652008083 active site 452652008084 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 452652008085 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 452652008086 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 452652008087 Beta-lactamase; Region: Beta-lactamase; pfam00144 452652008088 Helix-turn-helix domain; Region: HTH_36; pfam13730 452652008089 ParB-like nuclease domain; Region: ParBc; cl02129 452652008090 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 452652008091 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652008092 non-specific DNA binding site [nucleotide binding]; other site 452652008093 salt bridge; other site 452652008094 sequence-specific DNA binding site [nucleotide binding]; other site 452652008095 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 452652008096 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 452652008097 catalytic residues [active] 452652008098 catalytic nucleophile [active] 452652008099 Recombinase; Region: Recombinase; pfam07508 452652008100 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 452652008101 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 452652008102 Domain of unknown function (DUF307); Region: DUF307; pfam03733 452652008103 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 452652008104 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 452652008105 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 452652008106 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 452652008107 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 452652008108 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 452652008109 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 452652008110 Short C-terminal domain; Region: SHOCT; pfam09851 452652008111 heat shock protein HtpX; Provisional; Region: PRK03072 452652008112 NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; Region: NuoN; COG1007 452652008113 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 452652008114 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 452652008115 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 452652008116 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 452652008117 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 452652008118 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 452652008119 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 452652008120 4Fe-4S binding domain; Region: Fer4; pfam00037 452652008121 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 452652008122 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 452652008123 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 452652008124 NADH dehydrogenase subunit B; Validated; Region: PRK06411 452652008125 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 452652008126 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 452652008127 Histidine kinase; Region: HisKA_3; pfam07730 452652008128 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 452652008129 Mg2+ binding site [ion binding]; other site 452652008130 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 452652008131 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 452652008132 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 452652008133 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652008134 NAD(P) binding site [chemical binding]; other site 452652008135 active site 452652008136 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 452652008137 Catalytic domain of Protein Kinases; Region: PKc; cd00180 452652008138 active site 452652008139 ATP binding site [chemical binding]; other site 452652008140 substrate binding site [chemical binding]; other site 452652008141 activation loop (A-loop); other site 452652008142 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 452652008143 PQQ-like domain; Region: PQQ_2; pfam13360 452652008144 Trp docking motif [polypeptide binding]; other site 452652008145 active site 452652008146 PQQ-like domain; Region: PQQ_2; pfam13360 452652008147 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652008148 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652008149 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 452652008150 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 452652008151 dimer interface [polypeptide binding]; other site 452652008152 active site 452652008153 CoA binding pocket [chemical binding]; other site 452652008154 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 452652008155 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 452652008156 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 452652008157 FeS/SAM binding site; other site 452652008158 serine racemase; Region: PLN02970 452652008159 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 452652008160 tetramer interface [polypeptide binding]; other site 452652008161 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652008162 catalytic residue [active] 452652008163 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 452652008164 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 452652008165 putative DNA binding site [nucleotide binding]; other site 452652008166 putative Zn2+ binding site [ion binding]; other site 452652008167 AsnC family; Region: AsnC_trans_reg; pfam01037 452652008168 Flavoprotein; Region: Flavoprotein; pfam02441 452652008169 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 452652008170 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 452652008171 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 452652008172 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 452652008173 MOSC domain; Region: MOSC; pfam03473 452652008174 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 452652008175 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 452652008176 transcriptional regulator protein; Region: phnR; TIGR03337 452652008177 DNA-binding site [nucleotide binding]; DNA binding site 452652008178 UTRA domain; Region: UTRA; pfam07702 452652008179 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 452652008180 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 452652008181 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 452652008182 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 452652008183 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 452652008184 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 452652008185 Walker A/P-loop; other site 452652008186 ATP binding site [chemical binding]; other site 452652008187 Q-loop/lid; other site 452652008188 ABC transporter signature motif; other site 452652008189 Walker B; other site 452652008190 D-loop; other site 452652008191 H-loop/switch region; other site 452652008192 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 452652008193 L-aspartate oxidase; Provisional; Region: PRK06175 452652008194 prenyltransferase; Reviewed; Region: ubiA; PRK12888 452652008195 UbiA prenyltransferase family; Region: UbiA; pfam01040 452652008196 menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701 452652008197 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 452652008198 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 452652008199 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 452652008200 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 452652008201 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 452652008202 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 452652008203 ResB-like family; Region: ResB; pfam05140 452652008204 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 452652008205 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 452652008206 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 452652008207 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 452652008208 catalytic residues [active] 452652008209 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 452652008210 catalytic core [active] 452652008211 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 452652008212 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 452652008213 inhibitor-cofactor binding pocket; inhibition site 452652008214 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652008215 catalytic residue [active] 452652008216 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 452652008217 substrate binding site [chemical binding]; other site 452652008218 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 452652008219 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452652008220 D-alanine--poly(phosphoribitol) ligase, subunit 1; Region: D-ala-DACP-lig; TIGR01734 452652008221 acyl-activating enzyme (AAE) consensus motif; other site 452652008222 AMP binding site [chemical binding]; other site 452652008223 active site 452652008224 CoA binding site [chemical binding]; other site 452652008225 Condensation domain; Region: Condensation; pfam00668 452652008226 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 452652008227 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 452652008228 acyl-activating enzyme (AAE) consensus motif; other site 452652008229 AMP binding site [chemical binding]; other site 452652008230 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 452652008231 TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271 452652008232 H+ Antiporter protein; Region: 2A0121; TIGR00900 452652008233 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652008234 S-adenosylmethionine binding site [chemical binding]; other site 452652008235 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 452652008236 active site 452652008237 HIGH motif; other site 452652008238 nucleotide binding site [chemical binding]; other site 452652008239 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 452652008240 KMSKS motif; other site 452652008241 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 452652008242 NAD binding site [chemical binding]; other site 452652008243 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 452652008244 NAD(P) binding site [chemical binding]; other site 452652008245 catalytic residues [active] 452652008246 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 452652008247 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652008248 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652008249 dimerization interface [polypeptide binding]; other site 452652008250 DNA binding residues [nucleotide binding] 452652008251 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 452652008252 arginine-tRNA ligase; Region: PLN02286 452652008253 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 452652008254 active site 452652008255 HIGH motif; other site 452652008256 KMSK motif region; other site 452652008257 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 452652008258 tRNA binding surface [nucleotide binding]; other site 452652008259 anticodon binding site; other site 452652008260 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 452652008261 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 452652008262 DNA-binding site [nucleotide binding]; DNA binding site 452652008263 UTRA domain; Region: UTRA; pfam07702 452652008264 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 452652008265 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652008266 ATP binding site [chemical binding]; other site 452652008267 Mg2+ binding site [ion binding]; other site 452652008268 G-X-G motif; other site 452652008269 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 452652008270 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 452652008271 Small secreted domain (DUF320); Region: DUF320; pfam03777 452652008272 Small secreted domain (DUF320); Region: DUF320; pfam03777 452652008273 Small secreted domain (DUF320); Region: DUF320; pfam03777 452652008274 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 452652008275 dimer interface [polypeptide binding]; other site 452652008276 active site 452652008277 Schiff base residues; other site 452652008278 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 452652008279 active site 452652008280 homodimer interface [polypeptide binding]; other site 452652008281 SAM binding site [chemical binding]; other site 452652008282 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 452652008283 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 452652008284 active site 452652008285 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 452652008286 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 452652008287 domain interfaces; other site 452652008288 active site 452652008289 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 452652008290 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 452652008291 tRNA; other site 452652008292 putative tRNA binding site [nucleotide binding]; other site 452652008293 putative NADP binding site [chemical binding]; other site 452652008294 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 452652008295 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 452652008296 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 452652008297 CoA binding domain; Region: CoA_binding; pfam02629 452652008298 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 452652008299 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 452652008300 active site 452652008301 catalytic site [active] 452652008302 substrate binding site [chemical binding]; other site 452652008303 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 452652008304 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 452652008305 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 452652008306 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 452652008307 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652008308 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452652008309 DNA binding residues [nucleotide binding] 452652008310 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 452652008311 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 452652008312 putative acyl-acceptor binding pocket; other site 452652008313 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652008314 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 452652008315 NAD(P) binding site [chemical binding]; other site 452652008316 active site 452652008317 DNA binding domain, excisionase family; Region: excise; TIGR01764 452652008318 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 452652008319 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 452652008320 active site 452652008321 Zn binding site [ion binding]; other site 452652008322 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652008323 Major Facilitator Superfamily; Region: MFS_1; pfam07690 452652008324 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 452652008325 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 452652008326 motif II; other site 452652008327 pyrroline-5-carboxylate reductase; Region: PLN02688 452652008328 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 452652008329 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 452652008330 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652008331 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 452652008332 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 452652008333 active site 452652008334 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 452652008335 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 452652008336 DNA interaction; other site 452652008337 Metal-binding active site; metal-binding site 452652008338 exopolyphosphatase; Region: exo_poly_only; TIGR03706 452652008339 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 452652008340 Xanthomonas XOO_2897-like deaminase; Region: XOO_2897-deam; pfam14440 452652008341 SUKH-4 immunity protein; Region: SUKH-4; pfam14435 452652008342 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 452652008343 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 452652008344 Uncharacterized conserved protein [Function unknown]; Region: COG1565 452652008345 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 452652008346 Histidine kinase; Region: HisKA_3; pfam07730 452652008347 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 452652008348 ATP binding site [chemical binding]; other site 452652008349 Mg2+ binding site [ion binding]; other site 452652008350 G-X-G motif; other site 452652008351 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652008352 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652008353 active site 452652008354 phosphorylation site [posttranslational modification] 452652008355 intermolecular recognition site; other site 452652008356 dimerization interface [polypeptide binding]; other site 452652008357 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652008358 DNA binding residues [nucleotide binding] 452652008359 dimerization interface [polypeptide binding]; other site 452652008360 Rossmann-like domain; Region: Rossmann-like; pfam10727 452652008361 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 452652008362 pantoate--beta-alanine ligase; Region: panC; TIGR00018 452652008363 Pantoate-beta-alanine ligase; Region: PanC; cd00560 452652008364 active site 452652008365 ATP-binding site [chemical binding]; other site 452652008366 pantoate-binding site; other site 452652008367 HXXH motif; other site 452652008368 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 452652008369 tetramerization interface [polypeptide binding]; other site 452652008370 active site 452652008371 L-aspartate oxidase; Provisional; Region: PRK07804 452652008372 L-aspartate oxidase; Provisional; Region: PRK06175 452652008373 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 452652008374 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 452652008375 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 452652008376 dimerization interface [polypeptide binding]; other site 452652008377 active site 452652008378 pantothenate kinase; Reviewed; Region: PRK13318 452652008379 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 452652008380 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 452652008381 putative anticodon binding site; other site 452652008382 dimer interface [polypeptide binding]; other site 452652008383 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 452652008384 motif 1; other site 452652008385 dimer interface [polypeptide binding]; other site 452652008386 active site 452652008387 motif 2; other site 452652008388 motif 3; other site 452652008389 Penicillinase repressor; Region: Pencillinase_R; cl17580 452652008390 N-acetylglutamate synthase; Validated; Region: PRK07922 452652008391 Lsr2; Region: Lsr2; pfam11774 452652008392 Clp protease ATP binding subunit; Region: clpC; CHL00095 452652008393 Clp amino terminal domain; Region: Clp_N; pfam02861 452652008394 Clp amino terminal domain; Region: Clp_N; pfam02861 452652008395 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452652008396 Walker A motif; other site 452652008397 ATP binding site [chemical binding]; other site 452652008398 Walker B motif; other site 452652008399 arginine finger; other site 452652008400 UvrB/uvrC motif; Region: UVR; pfam02151 452652008401 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452652008402 Walker A motif; other site 452652008403 ATP binding site [chemical binding]; other site 452652008404 Walker B motif; other site 452652008405 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 452652008406 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 452652008407 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 452652008408 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 452652008409 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 452652008410 catalytic residue [active] 452652008411 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 452652008412 Peptidase family M23; Region: Peptidase_M23; pfam01551 452652008413 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652008414 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652008415 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652008416 Major Facilitator Superfamily; Region: MFS_1; pfam07690 452652008417 putative substrate translocation pore; other site 452652008418 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652008419 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 452652008420 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 452652008421 minor groove reading motif; other site 452652008422 helix-hairpin-helix signature motif; other site 452652008423 active site 452652008424 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 452652008425 Rhomboid family; Region: Rhomboid; cl11446 452652008426 H+ Antiporter protein; Region: 2A0121; TIGR00900 452652008427 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 452652008428 dimerization interface [polypeptide binding]; other site 452652008429 putative DNA binding site [nucleotide binding]; other site 452652008430 putative Zn2+ binding site [ion binding]; other site 452652008431 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 452652008432 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 452652008433 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 452652008434 DNA repair protein RadA; Provisional; Region: PRK11823 452652008435 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 452652008436 Walker A motif; other site 452652008437 ATP binding site [chemical binding]; other site 452652008438 Walker B motif; other site 452652008439 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 452652008440 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 452652008441 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 452652008442 Sulfate transporter family; Region: Sulfate_transp; pfam00916 452652008443 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 452652008444 Uncharacterized conserved protein [Function unknown]; Region: COG5361 452652008445 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 452652008446 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 452652008447 Uncharacterized conserved protein [Function unknown]; Region: COG5361 452652008448 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 452652008449 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 452652008450 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652008451 NADH(P)-binding; Region: NAD_binding_10; pfam13460 452652008452 NAD(P) binding site [chemical binding]; other site 452652008453 active site 452652008454 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 452652008455 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 452652008456 substrate binding pocket [chemical binding]; other site 452652008457 chain length determination region; other site 452652008458 substrate-Mg2+ binding site; other site 452652008459 catalytic residues [active] 452652008460 aspartate-rich region 1; other site 452652008461 active site lid residues [active] 452652008462 aspartate-rich region 2; other site 452652008463 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 452652008464 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 452652008465 ligand binding site [chemical binding]; other site 452652008466 flexible hinge region; other site 452652008467 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 452652008468 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 452652008469 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 452652008470 active site 452652008471 DNA binding site [nucleotide binding] 452652008472 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 452652008473 DNA binding site [nucleotide binding] 452652008474 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 452652008475 AAA ATPase domain; Region: AAA_16; pfam13191 452652008476 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452652008477 binding surface 452652008478 TPR motif; other site 452652008479 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452652008480 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452652008481 binding surface 452652008482 TPR motif; other site 452652008483 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452652008484 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 452652008485 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 452652008486 Walker A/P-loop; other site 452652008487 ATP binding site [chemical binding]; other site 452652008488 Q-loop/lid; other site 452652008489 ABC transporter signature motif; other site 452652008490 Walker B; other site 452652008491 D-loop; other site 452652008492 H-loop/switch region; other site 452652008493 TOBE domain; Region: TOBE_2; pfam08402 452652008494 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 452652008495 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 452652008496 active site 452652008497 Substrate binding site; other site 452652008498 Mg++ binding site; other site 452652008499 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 452652008500 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 452652008501 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 452652008502 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 452652008503 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 452652008504 active site 452652008505 HIGH motif; other site 452652008506 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 452652008507 KMSKS motif; other site 452652008508 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 452652008509 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 452652008510 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Reviewed; Region: ispF; PRK00084 452652008511 homotrimer interaction site [polypeptide binding]; other site 452652008512 zinc binding site [ion binding]; other site 452652008513 CDP-binding sites; other site 452652008514 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 452652008515 substrate binding site; other site 452652008516 dimer interface; other site 452652008517 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 452652008518 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 452652008519 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652008520 active site 452652008521 phosphorylation site [posttranslational modification] 452652008522 intermolecular recognition site; other site 452652008523 dimerization interface [polypeptide binding]; other site 452652008524 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 452652008525 DNA binding site [nucleotide binding] 452652008526 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452652008527 dimer interface [polypeptide binding]; other site 452652008528 phosphorylation site [posttranslational modification] 452652008529 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652008530 ATP binding site [chemical binding]; other site 452652008531 Mg2+ binding site [ion binding]; other site 452652008532 G-X-G motif; other site 452652008533 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 452652008534 PhoU domain; Region: PhoU; pfam01895 452652008535 PhoU domain; Region: PhoU; pfam01895 452652008536 Chitin binding domain; Region: Chitin_bind_3; pfam03067 452652008537 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 452652008538 catalytic core [active] 452652008539 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 452652008540 catalytic core [active] 452652008541 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652008542 Major Facilitator Superfamily; Region: MFS_1; pfam07690 452652008543 putative substrate translocation pore; other site 452652008544 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 452652008545 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 452652008546 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 452652008547 putative ADP-binding pocket [chemical binding]; other site 452652008548 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 452652008549 putative ADP-ribose binding site [chemical binding]; other site 452652008550 putative active site [active] 452652008551 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 452652008552 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 452652008553 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652008554 non-specific DNA binding site [nucleotide binding]; other site 452652008555 salt bridge; other site 452652008556 sequence-specific DNA binding site [nucleotide binding]; other site 452652008557 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 452652008558 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 452652008559 active site 452652008560 catalytic tetrad [active] 452652008561 Cupin; Region: Cupin_6; pfam12852 452652008562 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 452652008563 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452652008564 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 452652008565 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 452652008566 motif II; other site 452652008567 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 452652008568 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 452652008569 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 452652008570 ATP binding site [chemical binding]; other site 452652008571 putative Mg++ binding site [ion binding]; other site 452652008572 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 452652008573 nucleotide binding region [chemical binding]; other site 452652008574 ATP-binding site [chemical binding]; other site 452652008575 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 452652008576 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 452652008577 DNA binding site [nucleotide binding] 452652008578 active site 452652008579 Int/Topo IB signature motif; other site 452652008580 catalytic residues [active] 452652008581 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 452652008582 active site 452652008583 DNA binding site [nucleotide binding] 452652008584 Int/Topo IB signature motif; other site 452652008585 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 452652008586 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 452652008587 GIY-YIG motif/motif A; other site 452652008588 active site 452652008589 catalytic site [active] 452652008590 metal binding site [ion binding]; metal-binding site 452652008591 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 452652008592 active site 452652008593 substrate binding site [chemical binding]; other site 452652008594 ATP binding site [chemical binding]; other site 452652008595 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 452652008596 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 452652008597 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 452652008598 catalytic residue [active] 452652008599 Phosphotransferase enzyme family; Region: APH; pfam01636 452652008600 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 452652008601 active site 452652008602 substrate binding site [chemical binding]; other site 452652008603 ATP binding site [chemical binding]; other site 452652008604 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 452652008605 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 452652008606 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 452652008607 AAA domain; Region: AAA_18; pfam13238 452652008608 active site 452652008609 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 452652008610 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 452652008611 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 452652008612 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 452652008613 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 452652008614 Ligand binding site; other site 452652008615 metal-binding site 452652008616 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 452652008617 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 452652008618 NAD binding site [chemical binding]; other site 452652008619 putative substrate binding site 2 [chemical binding]; other site 452652008620 putative substrate binding site 1 [chemical binding]; other site 452652008621 active site 452652008622 HNH endonuclease; Region: HNH_2; pfam13391 452652008623 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 452652008624 SNF2 Helicase protein; Region: DUF3670; pfam12419 452652008625 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 452652008626 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452652008627 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 452652008628 Walker A motif; other site 452652008629 ATP binding site [chemical binding]; other site 452652008630 Walker B motif; other site 452652008631 arginine finger; other site 452652008632 Uncharacterized conserved protein [Function unknown]; Region: COG2353 452652008633 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 452652008634 potential protein location (hypothetical protein) that overlaps protein (putative drug resistance protein) 452652008635 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652008636 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652008637 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 452652008638 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452652008639 DNA binding residues [nucleotide binding] 452652008640 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 452652008641 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 452652008642 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 452652008643 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652008644 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 452652008645 DNA binding residues [nucleotide binding] 452652008646 hypothetical protein; Provisional; Region: PRK01346 452652008647 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 452652008648 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 452652008649 NlpC/P60 family; Region: NLPC_P60; pfam00877 452652008650 Uncharacterized conserved protein [Function unknown]; Region: COG2966 452652008651 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 452652008652 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 452652008653 Cation efflux family; Region: Cation_efflux; pfam01545 452652008654 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 452652008655 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652008656 ATP binding site [chemical binding]; other site 452652008657 Mg2+ binding site [ion binding]; other site 452652008658 G-X-G motif; other site 452652008659 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652008660 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652008661 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652008662 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652008663 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 452652008664 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 452652008665 active site 452652008666 Cupin domain; Region: Cupin_2; cl17218 452652008667 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652008668 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652008669 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652008670 putative substrate translocation pore; other site 452652008671 Domain of unknown function (DUF202); Region: DUF202; cl09954 452652008672 Domain of unknown function (DUF202); Region: DUF202; cl09954 452652008673 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 452652008674 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 452652008675 Ion channel; Region: Ion_trans_2; pfam07885 452652008676 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 452652008677 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 452652008678 active site 452652008679 ATP binding site [chemical binding]; other site 452652008680 substrate binding site [chemical binding]; other site 452652008681 activation loop (A-loop); other site 452652008682 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 452652008683 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652008684 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452652008685 DNA binding residues [nucleotide binding] 452652008686 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 452652008687 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 452652008688 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652008689 S-adenosylmethionine binding site [chemical binding]; other site 452652008690 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 452652008691 nudix motif; other site 452652008692 Predicted integral membrane protein [Function unknown]; Region: COG0392 452652008693 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 452652008694 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 452652008695 Walker A/P-loop; other site 452652008696 ATP binding site [chemical binding]; other site 452652008697 Q-loop/lid; other site 452652008698 ABC transporter signature motif; other site 452652008699 Walker B; other site 452652008700 D-loop; other site 452652008701 H-loop/switch region; other site 452652008702 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 452652008703 ABC-ATPase subunit interface; other site 452652008704 dimer interface [polypeptide binding]; other site 452652008705 putative PBP binding regions; other site 452652008706 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 452652008707 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 452652008708 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 452652008709 ABC-ATPase subunit interface; other site 452652008710 dimer interface [polypeptide binding]; other site 452652008711 putative PBP binding regions; other site 452652008712 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 452652008713 intersubunit interface [polypeptide binding]; other site 452652008714 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 452652008715 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 452652008716 FAD binding pocket [chemical binding]; other site 452652008717 FAD binding motif [chemical binding]; other site 452652008718 phosphate binding motif [ion binding]; other site 452652008719 NAD binding pocket [chemical binding]; other site 452652008720 Predicted transcriptional regulators [Transcription]; Region: COG1733 452652008721 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 452652008722 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 452652008723 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 452652008724 NAD(P) binding site [chemical binding]; other site 452652008725 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 452652008726 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 452652008727 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 452652008728 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652008729 NAD(P) binding site [chemical binding]; other site 452652008730 active site 452652008731 transcriptional activator FtrB; Provisional; Region: ftrB; PRK09392 452652008732 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 452652008733 ligand binding site [chemical binding]; other site 452652008734 flexible hinge region; other site 452652008735 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 452652008736 non-specific DNA interactions [nucleotide binding]; other site 452652008737 DNA binding site [nucleotide binding] 452652008738 sequence specific DNA binding site [nucleotide binding]; other site 452652008739 putative cAMP binding site [chemical binding]; other site 452652008740 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 452652008741 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 452652008742 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 452652008743 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652008744 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452652008745 DNA binding residues [nucleotide binding] 452652008746 Predicted transcriptional regulators [Transcription]; Region: COG1733 452652008747 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 452652008748 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 452652008749 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 452652008750 ATP binding site [chemical binding]; other site 452652008751 Mg2+ binding site [ion binding]; other site 452652008752 G-X-G motif; other site 452652008753 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652008754 ATP binding site [chemical binding]; other site 452652008755 Mg2+ binding site [ion binding]; other site 452652008756 G-X-G motif; other site 452652008757 cheY-homologous receiver domain; Region: REC; smart00448 452652008758 phosphorylation site [posttranslational modification] 452652008759 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 452652008760 additional DNA contacts [nucleotide binding]; other site 452652008761 mismatch recognition site; other site 452652008762 active site 452652008763 zinc binding site [ion binding]; other site 452652008764 DNA intercalation site [nucleotide binding]; other site 452652008765 AIPR protein; Region: AIPR; pfam10592 452652008766 Domain of unknown function (DUF4420); Region: DUF4420; pfam14390 452652008767 Z1 domain; Region: Z1; pfam10593 452652008768 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652008769 ATP binding site [chemical binding]; other site 452652008770 Mg2+ binding site [ion binding]; other site 452652008771 G-X-G motif; other site 452652008772 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 452652008773 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 452652008774 cofactor binding site; other site 452652008775 DNA binding site [nucleotide binding] 452652008776 substrate interaction site [chemical binding]; other site 452652008777 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 452652008778 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 452652008779 Phosphotransferase enzyme family; Region: APH; pfam01636 452652008780 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 452652008781 active site 452652008782 ATP binding site [chemical binding]; other site 452652008783 leucine export protein LeuE; Provisional; Region: PRK10958 452652008784 TAP-like protein; Region: Abhydrolase_4; pfam08386 452652008785 DNA polymerase III subunit delta'; Validated; Region: PRK07940 452652008786 DNA polymerase III subunit delta'; Validated; Region: PRK08485 452652008787 thymidylate kinase; Validated; Region: tmk; PRK00698 452652008788 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 452652008789 TMP-binding site; other site 452652008790 ATP-binding site [chemical binding]; other site 452652008791 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 452652008792 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 452652008793 active site 452652008794 interdomain interaction site; other site 452652008795 putative metal-binding site [ion binding]; other site 452652008796 nucleotide binding site [chemical binding]; other site 452652008797 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 452652008798 domain I; other site 452652008799 phosphate binding site [ion binding]; other site 452652008800 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 452652008801 domain II; other site 452652008802 domain III; other site 452652008803 nucleotide binding site [chemical binding]; other site 452652008804 DNA binding groove [nucleotide binding] 452652008805 catalytic site [active] 452652008806 domain IV; other site 452652008807 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 452652008808 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 452652008809 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 452652008810 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 452652008811 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652008812 S-adenosylmethionine binding site [chemical binding]; other site 452652008813 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 452652008814 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 452652008815 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 452652008816 anti sigma factor interaction site; other site 452652008817 regulatory phosphorylation site [posttranslational modification]; other site 452652008818 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 452652008819 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 452652008820 ATP binding site [chemical binding]; other site 452652008821 putative Mg++ binding site [ion binding]; other site 452652008822 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 452652008823 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 452652008824 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 452652008825 Type II/IV secretion system protein; Region: T2SE; pfam00437 452652008826 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 452652008827 ATP binding site [chemical binding]; other site 452652008828 Walker A motif; other site 452652008829 hexamer interface [polypeptide binding]; other site 452652008830 Walker B motif; other site 452652008831 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 452652008832 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 452652008833 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 452652008834 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 452652008835 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 452652008836 P-loop; other site 452652008837 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 452652008838 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 452652008839 Sulfate transporter family; Region: Sulfate_transp; pfam00916 452652008840 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 452652008841 active site clefts [active] 452652008842 zinc binding site [ion binding]; other site 452652008843 dimer interface [polypeptide binding]; other site 452652008844 acetyl-CoA synthetase; Provisional; Region: PRK00174 452652008845 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 452652008846 active site 452652008847 CoA binding site [chemical binding]; other site 452652008848 acyl-activating enzyme (AAE) consensus motif; other site 452652008849 AMP binding site [chemical binding]; other site 452652008850 acetate binding site [chemical binding]; other site 452652008851 Beta-lactamase; Region: Beta-lactamase; pfam00144 452652008852 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 452652008853 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 452652008854 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 452652008855 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 452652008856 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 452652008857 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 452652008858 Colicin V production protein; Region: Colicin_V; pfam02674 452652008859 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 452652008860 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 452652008861 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 452652008862 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 452652008863 putative active site [active] 452652008864 putative CoA binding site [chemical binding]; other site 452652008865 nudix motif; other site 452652008866 metal binding site [ion binding]; metal-binding site 452652008867 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 452652008868 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 452652008869 minor groove reading motif; other site 452652008870 helix-hairpin-helix signature motif; other site 452652008871 substrate binding pocket [chemical binding]; other site 452652008872 active site 452652008873 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 452652008874 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 452652008875 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652008876 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 452652008877 metal-binding site [ion binding] 452652008878 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 452652008879 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 452652008880 metal-binding site [ion binding] 452652008881 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 452652008882 Soluble P-type ATPase [General function prediction only]; Region: COG4087 452652008883 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 452652008884 Uncharacterized protein conserved in archaea (DUF2240); Region: DUF2240; cl01449 452652008885 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 452652008886 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 452652008887 MarR family; Region: MarR; pfam01047 452652008888 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 452652008889 hydrophobic ligand binding site; other site 452652008890 seryl-tRNA synthetase; Provisional; Region: PRK05431 452652008891 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 452652008892 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 452652008893 dimer interface [polypeptide binding]; other site 452652008894 active site 452652008895 motif 1; other site 452652008896 motif 2; other site 452652008897 motif 3; other site 452652008898 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 452652008899 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 452652008900 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 452652008901 active site 452652008902 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 452652008903 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 452652008904 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 452652008905 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 452652008906 Ligand Binding Site [chemical binding]; other site 452652008907 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452652008908 dimer interface [polypeptide binding]; other site 452652008909 phosphorylation site [posttranslational modification] 452652008910 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652008911 ATP binding site [chemical binding]; other site 452652008912 Mg2+ binding site [ion binding]; other site 452652008913 G-X-G motif; other site 452652008914 K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156 452652008915 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 452652008916 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 452652008917 Soluble P-type ATPase [General function prediction only]; Region: COG4087 452652008918 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 452652008919 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 452652008920 cytosine deaminase; Provisional; Region: PRK05985 452652008921 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 452652008922 active site 452652008923 Amino acid permease; Region: AA_permease; pfam00324 452652008924 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 452652008925 cytosine deaminase; Provisional; Region: PRK05985 452652008926 active site 452652008927 Transcriptional regulators [Transcription]; Region: GntR; COG1802 452652008928 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 452652008929 DNA-binding site [nucleotide binding]; DNA binding site 452652008930 FCD domain; Region: FCD; pfam07729 452652008931 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 452652008932 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 452652008933 ligand binding site [chemical binding]; other site 452652008934 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 452652008935 putative switch regulator; other site 452652008936 non-specific DNA interactions [nucleotide binding]; other site 452652008937 DNA binding site [nucleotide binding] 452652008938 sequence specific DNA binding site [nucleotide binding]; other site 452652008939 putative cAMP binding site [chemical binding]; other site 452652008940 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 452652008941 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 452652008942 nudix motif; other site 452652008943 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 452652008944 homotrimer interaction site [polypeptide binding]; other site 452652008945 putative active site [active] 452652008946 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 452652008947 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 452652008948 DTAP/Switch II; other site 452652008949 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 452652008950 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 452652008951 P loop; other site 452652008952 Nucleotide binding site [chemical binding]; other site 452652008953 DTAP/Switch II; other site 452652008954 Switch I; other site 452652008955 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 452652008956 Transcription factor WhiB; Region: Whib; pfam02467 452652008957 Transglycosylase; Region: Transgly; pfam00912 452652008958 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 452652008959 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 452652008960 Yqey-like protein; Region: YqeY; cl17540 452652008961 phosphodiesterase YaeI; Provisional; Region: PRK11340 452652008962 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 452652008963 putative active site [active] 452652008964 putative metal binding site [ion binding]; other site 452652008965 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 452652008966 hypothetical protein; Provisional; Region: PRK07907 452652008967 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 452652008968 active site 452652008969 metal binding site [ion binding]; metal-binding site 452652008970 dimer interface [polypeptide binding]; other site 452652008971 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 452652008972 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 452652008973 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 452652008974 active site 452652008975 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 452652008976 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 452652008977 dimerization interface [polypeptide binding]; other site 452652008978 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 452652008979 Bacterial Ig-like domain; Region: Big_5; pfam13205 452652008980 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 452652008981 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 452652008982 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 452652008983 conserved cys residue [active] 452652008984 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452652008985 Helix-turn-helix domain; Region: HTH_18; pfam12833 452652008986 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452652008987 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 452652008988 Coenzyme A binding pocket [chemical binding]; other site 452652008989 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 452652008990 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652008991 sequence-specific DNA binding site [nucleotide binding]; other site 452652008992 salt bridge; other site 452652008993 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 452652008994 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 452652008995 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 452652008996 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652008997 sequence-specific DNA binding site [nucleotide binding]; other site 452652008998 salt bridge; other site 452652008999 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 452652009000 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652009001 NAD(P) binding site [chemical binding]; other site 452652009002 active site 452652009003 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 452652009004 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 452652009005 DNA binding residues [nucleotide binding] 452652009006 aspartate kinase; Reviewed; Region: PRK06635 452652009007 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 452652009008 putative nucleotide binding site [chemical binding]; other site 452652009009 putative catalytic residues [active] 452652009010 putative Mg ion binding site [ion binding]; other site 452652009011 putative aspartate binding site [chemical binding]; other site 452652009012 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 452652009013 putative allosteric regulatory site; other site 452652009014 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 452652009015 putative allosteric regulatory residue; other site 452652009016 recombination protein RecR; Reviewed; Region: recR; PRK00076 452652009017 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 452652009018 RecR protein; Region: RecR; pfam02132 452652009019 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 452652009020 putative active site [active] 452652009021 putative metal-binding site [ion binding]; other site 452652009022 tetramer interface [polypeptide binding]; other site 452652009023 hypothetical protein; Validated; Region: PRK00153 452652009024 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 452652009025 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452652009026 Walker A motif; other site 452652009027 ATP binding site [chemical binding]; other site 452652009028 Walker B motif; other site 452652009029 arginine finger; other site 452652009030 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 452652009031 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 452652009032 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 452652009033 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 452652009034 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 452652009035 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 452652009036 Dimer interface [polypeptide binding]; other site 452652009037 anticodon binding site; other site 452652009038 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 452652009039 motif 1; other site 452652009040 dimer interface [polypeptide binding]; other site 452652009041 active site 452652009042 motif 2; other site 452652009043 motif 3; other site 452652009044 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 452652009045 PLD-like domain; Region: PLDc_2; pfam13091 452652009046 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 452652009047 putative active site [active] 452652009048 catalytic site [active] 452652009049 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 452652009050 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 452652009051 DNA-binding site [nucleotide binding]; DNA binding site 452652009052 RNA-binding motif; other site 452652009053 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 452652009054 DEAD-like helicases superfamily; Region: DEXDc; smart00487 452652009055 ATP binding site [chemical binding]; other site 452652009056 Mg++ binding site [ion binding]; other site 452652009057 motif III; other site 452652009058 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 452652009059 nucleotide binding region [chemical binding]; other site 452652009060 ATP-binding site [chemical binding]; other site 452652009061 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 452652009062 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 452652009063 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 452652009064 DNA binding residues [nucleotide binding] 452652009065 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 452652009066 intersubunit interface [polypeptide binding]; other site 452652009067 active site 452652009068 Zn2+ binding site [ion binding]; other site 452652009069 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 452652009070 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 452652009071 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 452652009072 DNA binding residues [nucleotide binding] 452652009073 dimer interface [polypeptide binding]; other site 452652009074 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 452652009075 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 452652009076 putative active site [active] 452652009077 putative metal binding site [ion binding]; other site 452652009078 Transcriptional regulator [Transcription]; Region: LysR; COG0583 452652009079 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 452652009080 LysR substrate binding domain; Region: LysR_substrate; pfam03466 452652009081 dimerization interface [polypeptide binding]; other site 452652009082 Lamin Tail Domain; Region: LTD; pfam00932 452652009083 SdiA-regulated; Region: SdiA-regulated; cd09971 452652009084 putative active site [active] 452652009085 Helix-turn-helix domain; Region: HTH_38; pfam13936 452652009086 MarR family; Region: MarR_2; cl17246 452652009087 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 452652009088 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652009089 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 452652009090 Walker A/P-loop; other site 452652009091 ATP binding site [chemical binding]; other site 452652009092 Q-loop/lid; other site 452652009093 ABC transporter signature motif; other site 452652009094 Walker B; other site 452652009095 D-loop; other site 452652009096 H-loop/switch region; other site 452652009097 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 452652009098 ABC-2 type transporter; Region: ABC2_membrane; cl17235 452652009099 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 452652009100 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452652009101 DNA binding residues [nucleotide binding] 452652009102 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 452652009103 Beta-lactamase; Region: Beta-lactamase; pfam00144 452652009104 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 452652009105 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 452652009106 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 452652009107 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 452652009108 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 452652009109 conserved cys residue [active] 452652009110 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452652009111 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452652009112 Protein of unknown function (DUF664); Region: DUF664; pfam04978 452652009113 DinB superfamily; Region: DinB_2; pfam12867 452652009114 HTH domain; Region: HTH_11; pfam08279 452652009115 Predicted transcriptional regulator [Transcription]; Region: COG2378 452652009116 WYL domain; Region: WYL; pfam13280 452652009117 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 452652009118 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 452652009119 DNA binding residues [nucleotide binding] 452652009120 putative dimer interface [polypeptide binding]; other site 452652009121 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652009122 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652009123 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 452652009124 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 452652009125 putative NAD(P) binding site [chemical binding]; other site 452652009126 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 452652009127 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 452652009128 Protein of unknown function (DUF664); Region: DUF664; pfam04978 452652009129 DinB superfamily; Region: DinB_2; pfam12867 452652009130 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 452652009131 translocation protein TolB; Provisional; Region: tolB; PRK02889 452652009132 translocation protein TolB; Provisional; Region: tolB; PRK02889 452652009133 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 452652009134 catalytic core [active] 452652009135 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 452652009136 substrate binding site [chemical binding]; other site 452652009137 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 452652009138 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 452652009139 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 452652009140 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 452652009141 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 452652009142 active site 452652009143 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 452652009144 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 452652009145 nucleoside/Zn binding site; other site 452652009146 dimer interface [polypeptide binding]; other site 452652009147 catalytic motif [active] 452652009148 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 452652009149 legume lectins; Region: lectin_L-type; cl14058 452652009150 carbohydrate binding site [chemical binding]; other site 452652009151 metal binding site [ion binding]; metal-binding site 452652009152 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 452652009153 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 452652009154 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652009155 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 452652009156 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452652009157 DNA binding residues [nucleotide binding] 452652009158 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 452652009159 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652009160 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 452652009161 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452652009162 DNA binding residues [nucleotide binding] 452652009163 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 452652009164 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 452652009165 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 452652009166 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 452652009167 active site 452652009168 catalytic tetrad [active] 452652009169 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 452652009170 NlpC/P60 family; Region: NLPC_P60; pfam00877 452652009171 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 452652009172 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 452652009173 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 452652009174 heme-binding site [chemical binding]; other site 452652009175 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 452652009176 heme-binding site [chemical binding]; other site 452652009177 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 452652009178 FAD binding pocket [chemical binding]; other site 452652009179 conserved FAD binding motif [chemical binding]; other site 452652009180 phosphate binding motif [ion binding]; other site 452652009181 beta-alpha-beta structure motif; other site 452652009182 NAD binding pocket [chemical binding]; other site 452652009183 ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187 452652009184 PAS domain; Region: PAS_9; pfam13426 452652009185 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 452652009186 putative active site [active] 452652009187 heme pocket [chemical binding]; other site 452652009188 PAS fold; Region: PAS; pfam00989 452652009189 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452652009190 putative active site [active] 452652009191 heme pocket [chemical binding]; other site 452652009192 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452652009193 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 452652009194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652009195 active site 452652009196 phosphorylation site [posttranslational modification] 452652009197 intermolecular recognition site; other site 452652009198 dimerization interface [polypeptide binding]; other site 452652009199 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 452652009200 dimerization interface [polypeptide binding]; other site 452652009201 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452652009202 dimer interface [polypeptide binding]; other site 452652009203 phosphorylation site [posttranslational modification] 452652009204 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652009205 ATP binding site [chemical binding]; other site 452652009206 Mg2+ binding site [ion binding]; other site 452652009207 G-X-G motif; other site 452652009208 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 452652009209 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652009210 active site 452652009211 phosphorylation site [posttranslational modification] 452652009212 intermolecular recognition site; other site 452652009213 dimerization interface [polypeptide binding]; other site 452652009214 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 452652009215 DNA binding site [nucleotide binding] 452652009216 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 452652009217 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 452652009218 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 452652009219 dimer interface [polypeptide binding]; other site 452652009220 acyl-activating enzyme (AAE) consensus motif; other site 452652009221 putative active site [active] 452652009222 AMP binding site [chemical binding]; other site 452652009223 putative CoA binding site [chemical binding]; other site 452652009224 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 452652009225 active site 452652009226 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 452652009227 FAD binding domain; Region: FAD_binding_4; pfam01565 452652009228 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 452652009229 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 452652009230 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 452652009231 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 452652009232 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 452652009233 Na binding site [ion binding]; other site 452652009234 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 452652009235 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 452652009236 putative active site [active] 452652009237 catalytic site [active] 452652009238 putative metal binding site [ion binding]; other site 452652009239 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 452652009240 SEC-C motif; Region: SEC-C; pfam02810 452652009241 Bifunctional DNA primase/polymerase, N-terminal; Region: Prim-Pol; smart00943 452652009242 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 452652009243 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 452652009244 proline aminopeptidase P II; Provisional; Region: PRK10879 452652009245 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 452652009246 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 452652009247 active site 452652009248 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 452652009249 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 452652009250 conserved cys residue [active] 452652009251 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452652009252 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 452652009253 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 452652009254 DNA binding residues [nucleotide binding] 452652009255 dimer interface [polypeptide binding]; other site 452652009256 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 452652009257 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 452652009258 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 452652009259 MarR family; Region: MarR; pfam01047 452652009260 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 452652009261 catalytic residues [active] 452652009262 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 452652009263 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 452652009264 DNA binding residues [nucleotide binding] 452652009265 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 452652009266 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452652009267 Coenzyme A binding pocket [chemical binding]; other site 452652009268 YCII-related domain; Region: YCII; cl00999 452652009269 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 452652009270 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 452652009271 DNA binding residues [nucleotide binding] 452652009272 MarR family; Region: MarR_2; pfam12802 452652009273 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 452652009274 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 452652009275 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 452652009276 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 452652009277 prolyl-tRNA synthetase; Provisional; Region: PRK09194 452652009278 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 452652009279 motif 1; other site 452652009280 dimer interface [polypeptide binding]; other site 452652009281 active site 452652009282 motif 2; other site 452652009283 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 452652009284 putative deacylase active site [active] 452652009285 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 452652009286 active site 452652009287 motif 3; other site 452652009288 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 452652009289 anticodon binding site; other site 452652009290 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 452652009291 Roadblock/LC7 domain; Region: Robl_LC7; pfam03259 452652009292 Protein of unknown function (DUF742); Region: DUF742; pfam05331 452652009293 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 452652009294 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 452652009295 G1 box; other site 452652009296 GTP/Mg2+ binding site [chemical binding]; other site 452652009297 G2 box; other site 452652009298 Switch I region; other site 452652009299 G3 box; other site 452652009300 Switch II region; other site 452652009301 G4 box; other site 452652009302 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 452652009303 Cytochrome P450; Region: p450; cl12078 452652009304 aromatic prenyltransferase, DMATS type; Region: arom_pren_DMATS; TIGR03429 452652009305 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 452652009306 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 452652009307 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 452652009308 H+ Antiporter protein; Region: 2A0121; TIGR00900 452652009309 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 452652009310 GIY-YIG motif/motif A; other site 452652009311 active site 452652009312 catalytic site [active] 452652009313 metal binding site [ion binding]; metal-binding site 452652009314 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719 452652009315 GIY-YIG motif/motif A; other site 452652009316 active site 452652009317 catalytic site [active] 452652009318 metal binding site [ion binding]; metal-binding site 452652009319 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 452652009320 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 452652009321 cofactor binding site; other site 452652009322 DNA binding site [nucleotide binding] 452652009323 substrate interaction site [chemical binding]; other site 452652009324 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 452652009325 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 452652009326 mismatch recognition site; other site 452652009327 additional DNA contacts [nucleotide binding]; other site 452652009328 active site 452652009329 zinc binding site [ion binding]; other site 452652009330 DNA intercalation site [nucleotide binding]; other site 452652009331 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 452652009332 GIY-YIG motif/motif A; other site 452652009333 active site 452652009334 catalytic site [active] 452652009335 metal binding site [ion binding]; metal-binding site 452652009336 potential frameshift: common BLAST hit: gi|239918312|ref|YP_002957870.1| integrase family protein 452652009337 Integrase core domain; Region: rve_3; pfam13683 452652009338 Helix-turn-helix domain; Region: HTH_28; pfam13518 452652009339 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 452652009340 DNA binding site [nucleotide binding] 452652009341 active site 452652009342 Int/Topo IB signature motif; other site 452652009343 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 452652009344 DDE superfamily endonuclease; Region: DDE_3; pfam13358 452652009345 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 452652009346 Winged helix-turn helix; Region: HTH_33; pfam13592 452652009347 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 452652009348 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 452652009349 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 452652009350 protein-splicing catalytic site; other site 452652009351 thioester formation/cholesterol transfer; other site 452652009352 Pretoxin HINT domain; Region: PT-HINT; pfam07591 452652009353 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 452652009354 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 452652009355 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 452652009356 putative sugar binding sites [chemical binding]; other site 452652009357 Q-X-W motif; other site 452652009358 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 452652009359 trimer interface [polypeptide binding]; other site 452652009360 active site 452652009361 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 452652009362 Yip1 domain; Region: Yip1; pfam04893 452652009363 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 452652009364 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 452652009365 active site 452652009366 Substrate binding site; other site 452652009367 Mg++ binding site; other site 452652009368 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 452652009369 N-terminal domain interface [polypeptide binding]; other site 452652009370 sulfate 1 binding site; other site 452652009371 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 452652009372 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 452652009373 Cysteine-rich domain; Region: CCG; pfam02754 452652009374 Cysteine-rich domain; Region: CCG; pfam02754 452652009375 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 452652009376 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 452652009377 nucleotide binding site [chemical binding]; other site 452652009378 NEF interaction site [polypeptide binding]; other site 452652009379 SBD interface [polypeptide binding]; other site 452652009380 GrpE; Region: GrpE; pfam01025 452652009381 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 452652009382 dimer interface [polypeptide binding]; other site 452652009383 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 452652009384 chaperone protein DnaJ; Provisional; Region: PRK14283 452652009385 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 452652009386 HSP70 interaction site [polypeptide binding]; other site 452652009387 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 452652009388 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 452652009389 dimer interface [polypeptide binding]; other site 452652009390 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 452652009391 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 452652009392 DNA binding residues [nucleotide binding] 452652009393 putative dimer interface [polypeptide binding]; other site 452652009394 Homeodomain-like domain; Region: HTH_23; pfam13384 452652009395 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 452652009396 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652009397 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 452652009398 dimerization interface [polypeptide binding]; other site 452652009399 DNA binding residues [nucleotide binding] 452652009400 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652009401 DNA binding residues [nucleotide binding] 452652009402 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652009403 dimerization interface [polypeptide binding]; other site 452652009404 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 452652009405 DNA binding residues [nucleotide binding] 452652009406 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652009407 dimerization interface [polypeptide binding]; other site 452652009408 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652009409 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652009410 dimerization interface [polypeptide binding]; other site 452652009411 DNA binding residues [nucleotide binding] 452652009412 PLD-like domain; Region: PLDc_2; pfam13091 452652009413 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652009414 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652009415 dimerization interface [polypeptide binding]; other site 452652009416 DNA binding residues [nucleotide binding] 452652009417 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652009418 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652009419 dimerization interface [polypeptide binding]; other site 452652009420 DNA binding residues [nucleotide binding] 452652009421 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 452652009422 gating phenylalanine in ion channel; other site 452652009423 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 452652009424 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 452652009425 putative dimerization interface [polypeptide binding]; other site 452652009426 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 452652009427 Clp amino terminal domain; Region: Clp_N; pfam02861 452652009428 Clp amino terminal domain; Region: Clp_N; pfam02861 452652009429 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452652009430 Walker A motif; other site 452652009431 ATP binding site [chemical binding]; other site 452652009432 Walker B motif; other site 452652009433 arginine finger; other site 452652009434 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452652009435 Walker A motif; other site 452652009436 ATP binding site [chemical binding]; other site 452652009437 Walker B motif; other site 452652009438 arginine finger; other site 452652009439 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 452652009440 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 452652009441 aminotransferase; Validated; Region: PRK07777 452652009442 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 452652009443 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652009444 homodimer interface [polypeptide binding]; other site 452652009445 catalytic residue [active] 452652009446 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 452652009447 spermidine synthase; Provisional; Region: PRK03612 452652009448 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652009449 S-adenosylmethionine binding site [chemical binding]; other site 452652009450 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 452652009451 hydrophobic ligand binding site; other site 452652009452 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 452652009453 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 452652009454 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 452652009455 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 452652009456 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 452652009457 active site 452652009458 intersubunit interface [polypeptide binding]; other site 452652009459 zinc binding site [ion binding]; other site 452652009460 Na+ binding site [ion binding]; other site 452652009461 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 452652009462 Xanthomonas XOO_2897-like deaminase; Region: XOO_2897-deam; pfam14440 452652009463 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 452652009464 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 452652009465 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 452652009466 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 452652009467 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 452652009468 dimerization interface [polypeptide binding]; other site 452652009469 ATP binding site [chemical binding]; other site 452652009470 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 452652009471 dimerization interface [polypeptide binding]; other site 452652009472 ATP binding site [chemical binding]; other site 452652009473 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 452652009474 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 452652009475 putative active site [active] 452652009476 catalytic triad [active] 452652009477 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 452652009478 Lsr2; Region: Lsr2; pfam11774 452652009479 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 452652009480 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 452652009481 Walker A/P-loop; other site 452652009482 ATP binding site [chemical binding]; other site 452652009483 Q-loop/lid; other site 452652009484 ABC transporter signature motif; other site 452652009485 Walker B; other site 452652009486 D-loop; other site 452652009487 H-loop/switch region; other site 452652009488 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 452652009489 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 452652009490 Histidine kinase; Region: HisKA_3; pfam07730 452652009491 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 452652009492 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652009493 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652009494 active site 452652009495 phosphorylation site [posttranslational modification] 452652009496 intermolecular recognition site; other site 452652009497 dimerization interface [polypeptide binding]; other site 452652009498 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652009499 DNA binding residues [nucleotide binding] 452652009500 dimerization interface [polypeptide binding]; other site 452652009501 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 452652009502 ATP binding site [chemical binding]; other site 452652009503 active site 452652009504 substrate binding site [chemical binding]; other site 452652009505 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 452652009506 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 452652009507 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 452652009508 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 452652009509 Transcriptional regulators [Transcription]; Region: FadR; COG2186 452652009510 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 452652009511 DNA-binding site [nucleotide binding]; DNA binding site 452652009512 Predicted amidohydrolase [General function prediction only]; Region: COG0388 452652009513 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 452652009514 putative active site [active] 452652009515 catalytic triad [active] 452652009516 putative dimer interface [polypeptide binding]; other site 452652009517 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 452652009518 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 452652009519 SCP-2 sterol transfer family; Region: SCP2; cl01225 452652009520 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652009521 putative substrate translocation pore; other site 452652009522 Major Facilitator Superfamily; Region: MFS_1; pfam07690 452652009523 IgA Peptidase M64; Region: Peptidase_M64; pfam09471 452652009524 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 452652009525 E3 interaction surface; other site 452652009526 lipoyl attachment site [posttranslational modification]; other site 452652009527 e3 binding domain; Region: E3_binding; pfam02817 452652009528 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 452652009529 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 452652009530 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 452652009531 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 452652009532 alpha subunit interface [polypeptide binding]; other site 452652009533 TPP binding site [chemical binding]; other site 452652009534 heterodimer interface [polypeptide binding]; other site 452652009535 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 452652009536 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 452652009537 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 452652009538 TPP-binding site [chemical binding]; other site 452652009539 tetramer interface [polypeptide binding]; other site 452652009540 heterodimer interface [polypeptide binding]; other site 452652009541 phosphorylation loop region [posttranslational modification] 452652009542 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652009543 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652009544 active site 452652009545 phosphorylation site [posttranslational modification] 452652009546 intermolecular recognition site; other site 452652009547 dimerization interface [polypeptide binding]; other site 452652009548 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652009549 DNA binding residues [nucleotide binding] 452652009550 dimerization interface [polypeptide binding]; other site 452652009551 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 452652009552 Phosphotransferase enzyme family; Region: APH; pfam01636 452652009553 active site 452652009554 substrate binding site [chemical binding]; other site 452652009555 ATP binding site [chemical binding]; other site 452652009556 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 452652009557 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 452652009558 active site 452652009559 ATP binding site [chemical binding]; other site 452652009560 substrate binding site [chemical binding]; other site 452652009561 activation loop (A-loop); other site 452652009562 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 452652009563 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 452652009564 active site 452652009565 ATP binding site [chemical binding]; other site 452652009566 substrate binding site [chemical binding]; other site 452652009567 activation loop (A-loop); other site 452652009568 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 452652009569 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 452652009570 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 452652009571 NAD(P) binding site [chemical binding]; other site 452652009572 Ion channel; Region: Ion_trans_2; pfam07885 452652009573 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 452652009574 TrkA-N domain; Region: TrkA_N; pfam02254 452652009575 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 452652009576 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 452652009577 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 452652009578 dimer interface [polypeptide binding]; other site 452652009579 putative functional site; other site 452652009580 putative MPT binding site; other site 452652009581 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 452652009582 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 452652009583 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 452652009584 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 452652009585 hypothetical protein; Provisional; Region: PRK01346 452652009586 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452652009587 Coenzyme A binding pocket [chemical binding]; other site 452652009588 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 452652009589 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 452652009590 Walker A motif; other site 452652009591 Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306 452652009592 Hom_end-associated Hint; Region: Hom_end_hint; pfam05203 452652009593 replicative DNA helicase; Region: DnaB; TIGR00665 452652009594 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 452652009595 ATP binding site [chemical binding]; other site 452652009596 Walker B motif; other site 452652009597 DNA binding loops [nucleotide binding] 452652009598 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 452652009599 putative efflux protein, MATE family; Region: matE; TIGR00797 452652009600 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 452652009601 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 452652009602 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 452652009603 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 452652009604 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 452652009605 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 452652009606 dimer interface [polypeptide binding]; other site 452652009607 ssDNA binding site [nucleotide binding]; other site 452652009608 tetramer (dimer of dimers) interface [polypeptide binding]; other site 452652009609 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 452652009610 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 452652009611 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 452652009612 Predicted integral membrane protein [Function unknown]; Region: COG5650 452652009613 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 452652009614 Transglycosylase; Region: Transgly; pfam00912 452652009615 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 452652009616 Predicted transcriptional regulators [Transcription]; Region: COG1695 452652009617 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 452652009618 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 452652009619 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 452652009620 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442 452652009621 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 452652009622 Homing endonuclease; Region: Hom_end; pfam05204 452652009623 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 452652009624 H+ Antiporter protein; Region: 2A0121; TIGR00900 452652009625 enterobactin exporter EntS; Provisional; Region: PRK10489 452652009626 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 452652009627 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 452652009628 active site 452652009629 NTP binding site [chemical binding]; other site 452652009630 metal binding triad [ion binding]; metal-binding site 452652009631 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 452652009632 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 452652009633 Zn2+ binding site [ion binding]; other site 452652009634 Mg2+ binding site [ion binding]; other site 452652009635 integral membrane protein MviN; Region: mviN; TIGR01695 452652009636 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 452652009637 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 452652009638 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 452652009639 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 452652009640 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 452652009641 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652009642 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452652009643 DNA binding residues [nucleotide binding] 452652009644 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 452652009645 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 452652009646 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 452652009647 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 452652009648 catalytic residues [active] 452652009649 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452652009650 Coenzyme A binding pocket [chemical binding]; other site 452652009651 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 452652009652 ParB-like nuclease domain; Region: ParBc; pfam02195 452652009653 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 452652009654 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 452652009655 Magnesium ion binding site [ion binding]; other site 452652009656 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 452652009657 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 452652009658 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 452652009659 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 452652009660 G-X-X-G motif; other site 452652009661 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 452652009662 RxxxH motif; other site 452652009663 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 452652009664 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 452652009665 Haemolytic domain; Region: Haemolytic; cl00506 452652009666 Ribonuclease P; Region: Ribonuclease_P; cl00457 452652009667 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 452652009668 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 452652009669 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452652009670 Walker A motif; other site 452652009671 ATP binding site [chemical binding]; other site 452652009672 Walker B motif; other site 452652009673 arginine finger; other site 452652009674 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 452652009675 DnaA box-binding interface [nucleotide binding]; other site 452652009676 DNA polymerase III subunit beta; Validated; Region: PRK07761 452652009677 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 452652009678 putative DNA binding surface [nucleotide binding]; other site 452652009679 dimer interface [polypeptide binding]; other site 452652009680 beta-clamp/clamp loader binding surface; other site 452652009681 beta-clamp/translesion DNA polymerase binding surface; other site 452652009682 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 452652009683 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 452652009684 recombination protein F; Reviewed; Region: recF; PRK00064 452652009685 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 452652009686 Walker A/P-loop; other site 452652009687 ATP binding site [chemical binding]; other site 452652009688 Q-loop/lid; other site 452652009689 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652009690 ABC transporter signature motif; other site 452652009691 Walker B; other site 452652009692 D-loop; other site 452652009693 H-loop/switch region; other site 452652009694 Protein of unknown function (DUF721); Region: DUF721; cl02324 452652009695 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 452652009696 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 452652009697 anchoring element; other site 452652009698 dimer interface [polypeptide binding]; other site 452652009699 ATP binding site [chemical binding]; other site 452652009700 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 452652009701 active site 452652009702 putative metal-binding site [ion binding]; other site 452652009703 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 452652009704 DNA gyrase subunit A; Validated; Region: PRK05560 452652009705 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 452652009706 CAP-like domain; other site 452652009707 active site 452652009708 primary dimer interface [polypeptide binding]; other site 452652009709 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 452652009710 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 452652009711 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 452652009712 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 452652009713 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 452652009714 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 452652009715 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 452652009716 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 452652009717 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652009718 S-adenosylmethionine binding site [chemical binding]; other site 452652009719 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 452652009720 active site 452652009721 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 452652009722 Uncharacterized protein family (UPF0233); Region: UPF0233; cl11506 452652009723 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 452652009724 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 452652009725 Glutamine amidotransferase class-I; Region: GATase; pfam00117 452652009726 glutamine binding [chemical binding]; other site 452652009727 catalytic triad [active] 452652009728 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 452652009729 active site 452652009730 catalytic site [active] 452652009731 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 452652009732 active site 452652009733 catalytic site [active] 452652009734 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 452652009735 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 452652009736 active site 452652009737 ATP binding site [chemical binding]; other site 452652009738 substrate binding site [chemical binding]; other site 452652009739 activation loop (A-loop); other site 452652009740 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 452652009741 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 452652009742 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 452652009743 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 452652009744 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 452652009745 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 452652009746 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 452652009747 active site 452652009748 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 452652009749 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 452652009750 phosphopeptide binding site; other site 452652009751 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 452652009752 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 452652009753 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 452652009754 phosphopeptide binding site; other site 452652009755 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 452652009756 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 452652009757 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652009758 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652009759 dimerization interface [polypeptide binding]; other site 452652009760 DNA binding residues [nucleotide binding] 452652009761 Histidine kinase; Region: HisKA_3; pfam07730 452652009762 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 452652009763 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652009764 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652009765 active site 452652009766 phosphorylation site [posttranslational modification] 452652009767 intermolecular recognition site; other site 452652009768 dimerization interface [polypeptide binding]; other site 452652009769 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652009770 dimerization interface [polypeptide binding]; other site 452652009771 DNA binding residues [nucleotide binding] 452652009772 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 452652009773 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452652009774 PAS domain; Region: PAS_9; pfam13426 452652009775 putative active site [active] 452652009776 heme pocket [chemical binding]; other site 452652009777 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 452652009778 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 452652009779 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 452652009780 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 452652009781 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 452652009782 active site residue [active] 452652009783 Horizontally Transferred TransMembrane Domain; Region: HTTM; smart00752 452652009784 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 452652009785 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 452652009786 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 452652009787 peptidase domain interface [polypeptide binding]; other site 452652009788 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 452652009789 active site 452652009790 catalytic triad [active] 452652009791 calcium binding site [ion binding]; other site 452652009792 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 452652009793 hypothetical protein; Provisional; Region: PRK08244 452652009794 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 452652009795 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 452652009796 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 452652009797 Ligand binding site; other site 452652009798 Ligand binding site; other site 452652009799 Ligand binding site; other site 452652009800 Putative Catalytic site; other site 452652009801 DXD motif; other site 452652009802 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 452652009803 AAA domain; Region: AAA_18; pfam13238 452652009804 active site 452652009805 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 452652009806 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 452652009807 NAD(P) binding site [chemical binding]; other site 452652009808 catalytic residues [active] 452652009809 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 452652009810 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 452652009811 Ligand binding site; other site 452652009812 Putative Catalytic site; other site 452652009813 DXD motif; other site 452652009814 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652009815 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652009816 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 452652009817 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 452652009818 putative DNA binding site [nucleotide binding]; other site 452652009819 putative Zn2+ binding site [ion binding]; other site 452652009820 AsnC family; Region: AsnC_trans_reg; pfam01037 452652009821 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 452652009822 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 452652009823 tetramer interface [polypeptide binding]; other site 452652009824 TPP-binding site [chemical binding]; other site 452652009825 heterodimer interface [polypeptide binding]; other site 452652009826 phosphorylation loop region [posttranslational modification] 452652009827 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 452652009828 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 452652009829 alpha subunit interface [polypeptide binding]; other site 452652009830 TPP binding site [chemical binding]; other site 452652009831 heterodimer interface [polypeptide binding]; other site 452652009832 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 452652009833 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 452652009834 E3 interaction surface; other site 452652009835 lipoyl attachment site [posttranslational modification]; other site 452652009836 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 452652009837 e3 binding domain; Region: E3_binding; pfam02817 452652009838 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 452652009839 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 452652009840 heme-binding site [chemical binding]; other site 452652009841 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 452652009842 FAD binding pocket [chemical binding]; other site 452652009843 conserved FAD binding motif [chemical binding]; other site 452652009844 phosphate binding motif [ion binding]; other site 452652009845 beta-alpha-beta structure motif; other site 452652009846 NAD binding pocket [chemical binding]; other site 452652009847 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 452652009848 nudix motif; other site 452652009849 Transcriptional regulator [Transcription]; Region: IclR; COG1414 452652009850 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 452652009851 Bacterial transcriptional regulator; Region: IclR; pfam01614 452652009852 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 452652009853 Membrane protein of unknown function; Region: DUF360; pfam04020 452652009854 Cupin domain; Region: Cupin_2; pfam07883 452652009855 Putative transcription activator [Transcription]; Region: TenA; COG0819 452652009856 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652009857 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 452652009858 NAD(P) binding site [chemical binding]; other site 452652009859 active site 452652009860 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452652009861 acyl-activating enzyme (AAE) consensus motif; other site 452652009862 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452652009863 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 452652009864 CoA binding site [chemical binding]; other site 452652009865 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 452652009866 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 452652009867 active site 452652009868 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258 452652009869 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 452652009870 active site 452652009871 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 452652009872 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 452652009873 ThiC-associated domain; Region: ThiC-associated; pfam13667 452652009874 ThiC family; Region: ThiC; pfam01964 452652009875 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 452652009876 putative active site [active] 452652009877 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 452652009878 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 452652009879 metal binding site [ion binding]; metal-binding site 452652009880 dimer interface [polypeptide binding]; other site 452652009881 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 452652009882 AsnC family; Region: AsnC_trans_reg; pfam01037 452652009883 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 452652009884 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652009885 Major Facilitator Superfamily; Region: MFS_1; pfam07690 452652009886 Domain of unknown function (DUF397); Region: DUF397; pfam04149 452652009887 potential frameshift: common BLAST hit: gi|345009219|ref|YP_004811573.1| helix-turn-helix domain-containing protein 452652009888 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 452652009889 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652009890 non-specific DNA binding site [nucleotide binding]; other site 452652009891 salt bridge; other site 452652009892 sequence-specific DNA binding site [nucleotide binding]; other site 452652009893 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 452652009894 Mg2+ binding site [ion binding]; other site 452652009895 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 452652009896 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 452652009897 active site 452652009898 metal binding site [ion binding]; metal-binding site 452652009899 Transcriptional regulators [Transcription]; Region: PurR; COG1609 452652009900 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 452652009901 DNA binding site [nucleotide binding] 452652009902 domain linker motif; other site 452652009903 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 452652009904 ligand binding site [chemical binding]; other site 452652009905 dimerization interface [polypeptide binding]; other site 452652009906 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 452652009907 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 452652009908 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652009909 homodimer interface [polypeptide binding]; other site 452652009910 catalytic residue [active] 452652009911 tryptophan synthase subunit beta; Reviewed; Region: PRK12391 452652009912 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 452652009913 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 452652009914 catalytic residue [active] 452652009915 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 452652009916 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 452652009917 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652009918 non-specific DNA binding site [nucleotide binding]; other site 452652009919 salt bridge; other site 452652009920 sequence-specific DNA binding site [nucleotide binding]; other site 452652009921 methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188 452652009922 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652009923 S-adenosylmethionine binding site [chemical binding]; other site 452652009924 Transposase; Region: DEDD_Tnp_IS110; pfam01548 452652009925 macrolide transporter subunit MacA; Provisional; Region: PRK11578 452652009926 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 452652009927 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 452652009928 Walker A/P-loop; other site 452652009929 ATP binding site [chemical binding]; other site 452652009930 Q-loop/lid; other site 452652009931 ABC transporter signature motif; other site 452652009932 Walker B; other site 452652009933 D-loop; other site 452652009934 H-loop/switch region; other site 452652009935 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452652009936 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 452652009937 FtsX-like permease family; Region: FtsX; pfam02687 452652009938 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 452652009939 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652009940 active site 452652009941 phosphorylation site [posttranslational modification] 452652009942 intermolecular recognition site; other site 452652009943 dimerization interface [polypeptide binding]; other site 452652009944 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 452652009945 DNA binding site [nucleotide binding] 452652009946 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452652009947 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 452652009948 dimerization interface [polypeptide binding]; other site 452652009949 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452652009950 dimer interface [polypeptide binding]; other site 452652009951 phosphorylation site [posttranslational modification] 452652009952 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652009953 ATP binding site [chemical binding]; other site 452652009954 Mg2+ binding site [ion binding]; other site 452652009955 G-X-G motif; other site 452652009956 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 452652009957 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 452652009958 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 452652009959 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 452652009960 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 452652009961 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 452652009962 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 452652009963 Walker A/P-loop; other site 452652009964 ATP binding site [chemical binding]; other site 452652009965 Q-loop/lid; other site 452652009966 ABC transporter signature motif; other site 452652009967 Walker B; other site 452652009968 D-loop; other site 452652009969 H-loop/switch region; other site 452652009970 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 452652009971 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652009972 Walker A/P-loop; other site 452652009973 ATP binding site [chemical binding]; other site 452652009974 Q-loop/lid; other site 452652009975 ABC transporter signature motif; other site 452652009976 Walker B; other site 452652009977 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 452652009978 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 452652009979 GAF domain; Region: GAF_3; pfam13492 452652009980 Histidine kinase; Region: HisKA_3; pfam07730 452652009981 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652009982 ATP binding site [chemical binding]; other site 452652009983 Mg2+ binding site [ion binding]; other site 452652009984 G-X-G motif; other site 452652009985 Protein of unknown function DUF72; Region: DUF72; pfam01904 452652009986 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 452652009987 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 452652009988 YtkA-like; Region: YtkA; pfam13115 452652009989 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 452652009990 Putative ParB-like nuclease; Region: ParBc_2; cl17538 452652009991 Calcium binding; Region: Calci_bind_CcbP; pfam11535 452652009992 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 452652009993 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 452652009994 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 452652009995 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 452652009996 Helix-turn-helix domain; Region: HTH_36; pfam13730 452652009997 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 452652009998 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 452652009999 tRNA synthetases class I (C) catalytic domain; Region: tRNA-synt_1e; pfam01406 452652010000 active site 452652010001 HIGH motif; other site 452652010002 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 452652010003 KMSKS motif; other site 452652010004 tRNA binding surface [nucleotide binding]; other site 452652010005 anticodon binding site; other site 452652010006 This DALR domain is found in cysteinyl-tRNA-synthetases; Region: DALR_2; smart00840 452652010007 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 452652010008 Sugar-transfer associated ATP-grasp; Region: ATPgrasp_ST; pfam14397 452652010009 alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291 452652010010 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652010011 non-specific DNA binding site [nucleotide binding]; other site 452652010012 salt bridge; other site 452652010013 sequence-specific DNA binding site [nucleotide binding]; other site 452652010014 HD domain; Region: HD_3; pfam13023 452652010015 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 452652010016 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 452652010017 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 452652010018 AAA domain; Region: AAA_25; pfam13481 452652010019 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 452652010020 Walker A motif; other site 452652010021 ATP binding site [chemical binding]; other site 452652010022 Walker B motif; other site 452652010023 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 452652010024 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 452652010025 catalytic residues [active] 452652010026 catalytic nucleophile [active] 452652010027 Recombinase; Region: Recombinase; pfam07508 452652010028 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 452652010029 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 452652010030 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 452652010031 aspartate carbamoyltransferase; Provisional; Region: PRK08192 452652010032 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 452652010033 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 452652010034 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 452652010035 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 452652010036 Walker A/P-loop; other site 452652010037 ATP binding site [chemical binding]; other site 452652010038 Q-loop/lid; other site 452652010039 ABC transporter signature motif; other site 452652010040 Walker B; other site 452652010041 D-loop; other site 452652010042 H-loop/switch region; other site 452652010043 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 452652010044 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 452652010045 Walker A/P-loop; other site 452652010046 ATP binding site [chemical binding]; other site 452652010047 Q-loop/lid; other site 452652010048 ABC transporter signature motif; other site 452652010049 Walker B; other site 452652010050 D-loop; other site 452652010051 H-loop/switch region; other site 452652010052 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 452652010053 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 452652010054 Transcriptional regulators [Transcription]; Region: FadR; COG2186 452652010055 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 452652010056 DNA-binding site [nucleotide binding]; DNA binding site 452652010057 FCD domain; Region: FCD; pfam07729 452652010058 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 452652010059 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652010060 non-specific DNA binding site [nucleotide binding]; other site 452652010061 salt bridge; other site 452652010062 sequence-specific DNA binding site [nucleotide binding]; other site 452652010063 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 452652010064 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 452652010065 ATP binding site [chemical binding]; other site 452652010066 Mg2+ binding site [ion binding]; other site 452652010067 G-X-G motif; other site 452652010068 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 452652010069 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 452652010070 metal binding site [ion binding]; metal-binding site 452652010071 substrate binding pocket [chemical binding]; other site 452652010072 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 452652010073 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 452652010074 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 452652010075 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 452652010076 metal binding site [ion binding]; metal-binding site 452652010077 active site 452652010078 I-site; other site 452652010079 XFP N-terminal domain; Region: XFP_N; pfam09364 452652010080 XFP C-terminal domain; Region: XFP_C; pfam09363 452652010081 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 452652010082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652010083 S-adenosylmethionine binding site [chemical binding]; other site 452652010084 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 452652010085 active site 452652010086 motif I; other site 452652010087 motif II; other site 452652010088 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 452652010089 sugar binding site [chemical binding]; other site 452652010090 Glycosyl hydrolase family 46 chitosanase domain. This family are composed of the chitosanase enzymes which hydrolyzes chitosan, a biopolymer of beta (1,4)-linked -D-glucosamine (GlcN) residues produced by partial or full deacetylation of chitin; Region: chitosanase_glyco_hydro_46; cd00978 452652010091 chitosan binding site [chemical binding]; other site 452652010092 catalytic residues [active] 452652010093 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 452652010094 dimerization interface [polypeptide binding]; other site 452652010095 putative DNA binding site [nucleotide binding]; other site 452652010096 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 452652010097 putative Zn2+ binding site [ion binding]; other site 452652010098 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 452652010099 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 452652010100 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 452652010101 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 452652010102 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652010103 dimer interface [polypeptide binding]; other site 452652010104 conserved gate region; other site 452652010105 putative PBP binding loops; other site 452652010106 ABC-ATPase subunit interface; other site 452652010107 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 452652010108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652010109 dimer interface [polypeptide binding]; other site 452652010110 conserved gate region; other site 452652010111 putative PBP binding loops; other site 452652010112 ABC-ATPase subunit interface; other site 452652010113 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 452652010114 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 452652010115 NAD binding site [chemical binding]; other site 452652010116 sugar binding site [chemical binding]; other site 452652010117 divalent metal binding site [ion binding]; other site 452652010118 tetramer (dimer of dimers) interface [polypeptide binding]; other site 452652010119 dimer interface [polypeptide binding]; other site 452652010120 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 452652010121 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 452652010122 catalytic residue [active] 452652010123 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 452652010124 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 452652010125 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 452652010126 active site 452652010127 motif I; other site 452652010128 motif II; other site 452652010129 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 452652010130 seryl-tRNA synthetase; Provisional; Region: PRK05431 452652010131 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 452652010132 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 452652010133 dimer interface [polypeptide binding]; other site 452652010134 active site 452652010135 motif 1; other site 452652010136 motif 2; other site 452652010137 motif 3; other site 452652010138 prephenate dehydratase; Provisional; Region: PRK11898 452652010139 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 452652010140 membrane-bound complex binding site; other site 452652010141 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 452652010142 putative L-Phe binding site [chemical binding]; other site 452652010143 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 452652010144 CopC domain; Region: CopC; pfam04234 452652010145 Copper resistance protein D; Region: CopD; pfam05425 452652010146 YtkA-like; Region: YtkA; pfam13115 452652010147 Protein of unknown function (DUF461); Region: DUF461; pfam04314 452652010148 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 452652010149 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 452652010150 Cu(I) binding site [ion binding]; other site 452652010151 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 452652010152 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 452652010153 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 452652010154 Transmembrane secretion effector; Region: MFS_3; pfam05977 452652010155 YCII-related domain; Region: YCII; cl00999 452652010156 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652010157 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652010158 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 452652010159 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 452652010160 glycogen branching enzyme; Provisional; Region: PRK14705 452652010161 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 452652010162 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652010163 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452652010164 DNA binding residues [nucleotide binding] 452652010165 Homeodomain-like domain; Region: HTH_23; cl17451 452652010166 Integrase core domain; Region: rve; pfam00665 452652010167 Integrase core domain; Region: rve_3; pfam13683 452652010168 Excalibur calcium-binding domain; Region: Excalibur; smart00894 452652010169 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 452652010170 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 452652010171 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 452652010172 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 452652010173 Ligand Binding Site [chemical binding]; other site 452652010174 Molecular Tunnel; other site 452652010175 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 452652010176 active site 452652010177 substrate binding site [chemical binding]; other site 452652010178 ATP binding site [chemical binding]; other site 452652010179 Phosphotransferase enzyme family; Region: APH; pfam01636 452652010180 Pirin-related protein [General function prediction only]; Region: COG1741 452652010181 Pirin; Region: Pirin; pfam02678 452652010182 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 452652010183 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 452652010184 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 452652010185 catalytic residues [active] 452652010186 catalytic nucleophile [active] 452652010187 Recombinase; Region: Recombinase; pfam07508 452652010188 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 452652010189 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 452652010190 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 452652010191 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 452652010192 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 452652010193 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 452652010194 Ligand Binding Site [chemical binding]; other site 452652010195 Molecular Tunnel; other site 452652010196 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 452652010197 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 452652010198 dimer interface [polypeptide binding]; other site 452652010199 ADP-ribose binding site [chemical binding]; other site 452652010200 active site 452652010201 nudix motif; other site 452652010202 metal binding site [ion binding]; metal-binding site 452652010203 Pirin-related protein [General function prediction only]; Region: COG1741 452652010204 Pirin; Region: Pirin; pfam02678 452652010205 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 452652010206 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 452652010207 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 452652010208 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 452652010209 FAD binding site [chemical binding]; other site 452652010210 substrate binding site [chemical binding]; other site 452652010211 catalytic residues [active] 452652010212 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 452652010213 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 452652010214 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 452652010215 active site 452652010216 metal binding site [ion binding]; metal-binding site 452652010217 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 452652010218 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 452652010219 Phosphotransferase enzyme family; Region: APH; pfam01636 452652010220 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 452652010221 active site 452652010222 ATP binding site [chemical binding]; other site 452652010223 antibiotic binding site [chemical binding]; other site 452652010224 Tubby C 2; Region: Tub_2; cl02043 452652010225 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 452652010226 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 452652010227 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 452652010228 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 452652010229 GDP-binding site [chemical binding]; other site 452652010230 ACT binding site; other site 452652010231 IMP binding site; other site 452652010232 amidophosphoribosyltransferase; Provisional; Region: PRK07847 452652010233 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 452652010234 active site 452652010235 tetramer interface [polypeptide binding]; other site 452652010236 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 452652010237 active site 452652010238 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 452652010239 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 452652010240 dimerization interface [polypeptide binding]; other site 452652010241 putative ATP binding site [chemical binding]; other site 452652010242 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 452652010243 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 452652010244 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 452652010245 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 452652010246 NAD binding site [chemical binding]; other site 452652010247 Phe binding site; other site 452652010248 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 452652010249 DNA binding residues [nucleotide binding] 452652010250 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 452652010251 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 452652010252 ATP binding site [chemical binding]; other site 452652010253 putative Mg++ binding site [ion binding]; other site 452652010254 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 452652010255 nucleotide binding region [chemical binding]; other site 452652010256 ATP-binding site [chemical binding]; other site 452652010257 Helicase associated domain (HA2); Region: HA2; pfam04408 452652010258 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 452652010259 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 452652010260 Proteins of 100 residues with WXG; Region: WXG100; cl02005 452652010261 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 452652010262 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 452652010263 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652010264 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652010265 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652010266 sequence-specific DNA binding site [nucleotide binding]; other site 452652010267 salt bridge; other site 452652010268 putative glycosyl transferase; Provisional; Region: PRK10073 452652010269 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 452652010270 active site 452652010271 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 452652010272 amidase catalytic site [active] 452652010273 Zn binding residues [ion binding]; other site 452652010274 substrate binding site [chemical binding]; other site 452652010275 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652010276 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 452652010277 putative dimer interface [polypeptide binding]; other site 452652010278 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 452652010279 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652010280 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652010281 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 452652010282 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 452652010283 putative active site [active] 452652010284 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 452652010285 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 452652010286 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 452652010287 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 452652010288 DEAD-like helicases superfamily; Region: DEXDc; smart00487 452652010289 ATP binding site [chemical binding]; other site 452652010290 Mg++ binding site [ion binding]; other site 452652010291 motif III; other site 452652010292 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 452652010293 nucleotide binding region [chemical binding]; other site 452652010294 ATP-binding site [chemical binding]; other site 452652010295 TIGR02452 family protein; Region: TIGR02452 452652010296 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 452652010297 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 452652010298 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 452652010299 Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162 452652010300 classical (c) SDRs; Region: SDR_c; cd05233 452652010301 NAD(P) binding site [chemical binding]; other site 452652010302 active site 452652010303 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 452652010304 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 452652010305 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 452652010306 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 452652010307 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 452652010308 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 452652010309 active site 452652010310 multimer interface [polypeptide binding]; other site 452652010311 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 452652010312 nudix motif; other site 452652010313 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 452652010314 nudix motif; other site 452652010315 Helix-turn-helix domain; Region: HTH_28; pfam13518 452652010316 potential frameshift: common BLAST hit: gi|239918312|ref|YP_002957870.1| integrase family protein 452652010317 Integrase core domain; Region: rve_3; pfam13683 452652010318 DDE superfamily endonuclease; Region: DDE_5; pfam13546 452652010319 Mrr N-terminal domain; Region: Mrr_N; pfam14338 452652010320 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 452652010321 Transposase; Region: HTH_Tnp_1; pfam01527 452652010322 putative transposase OrfB; Reviewed; Region: PHA02517 452652010323 HTH-like domain; Region: HTH_21; pfam13276 452652010324 Integrase core domain; Region: rve; pfam00665 452652010325 Integrase core domain; Region: rve_3; pfam13683 452652010326 Lsr2; Region: Lsr2; pfam11774 452652010327 potential frameshift: common BLAST hit: gi|345015311|ref|YP_004817665.1| ECF subfamily RNA polymerase sigma-24 subunit 452652010328 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 452652010329 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652010330 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 452652010331 Moco binding site; other site 452652010332 metal coordination site [ion binding]; other site 452652010333 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 452652010334 Fasciclin domain; Region: Fasciclin; pfam02469 452652010335 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 452652010336 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652010337 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 452652010338 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 452652010339 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 452652010340 homodimer interface [polypeptide binding]; other site 452652010341 active site 452652010342 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 452652010343 arginine deiminase; Provisional; Region: PRK01388 452652010344 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 452652010345 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 452652010346 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 452652010347 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652010348 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452652010349 DNA binding residues [nucleotide binding] 452652010350 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 452652010351 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 452652010352 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 452652010353 Walker A/P-loop; other site 452652010354 ATP binding site [chemical binding]; other site 452652010355 Q-loop/lid; other site 452652010356 ABC transporter signature motif; other site 452652010357 Walker B; other site 452652010358 D-loop; other site 452652010359 H-loop/switch region; other site 452652010360 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 452652010361 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 452652010362 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 452652010363 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 452652010364 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452652010365 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452652010366 acyl-activating enzyme (AAE) consensus motif; other site 452652010367 acyl-activating enzyme (AAE) consensus motif; other site 452652010368 AMP binding site [chemical binding]; other site 452652010369 active site 452652010370 CoA binding site [chemical binding]; other site 452652010371 Phosphopantetheine attachment site; Region: PP-binding; cl09936 452652010372 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 452652010373 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 452652010374 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652010375 homodimer interface [polypeptide binding]; other site 452652010376 catalytic residue [active] 452652010377 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 452652010378 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 452652010379 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 452652010380 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 452652010381 dimer interface [polypeptide binding]; other site 452652010382 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652010383 catalytic residue [active] 452652010384 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 452652010385 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 452652010386 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 452652010387 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652010388 NAD(P) binding site [chemical binding]; other site 452652010389 active site 452652010390 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 452652010391 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 452652010392 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 452652010393 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452652010394 Coenzyme A binding pocket [chemical binding]; other site 452652010395 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 452652010396 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 452652010397 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 452652010398 dimer interface [polypeptide binding]; other site 452652010399 active site 452652010400 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 452652010401 active site 452652010402 M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580 452652010403 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652010404 Major Facilitator Superfamily; Region: MFS_1; pfam07690 452652010405 putative substrate translocation pore; other site 452652010406 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652010407 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652010408 DNA binding residues [nucleotide binding] 452652010409 dimerization interface [polypeptide binding]; other site 452652010410 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 452652010411 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 452652010412 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 452652010413 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 452652010414 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 452652010415 nucleotide binding site [chemical binding]; other site 452652010416 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 452652010417 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 452652010418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652010419 dimer interface [polypeptide binding]; other site 452652010420 conserved gate region; other site 452652010421 putative PBP binding loops; other site 452652010422 ABC-ATPase subunit interface; other site 452652010423 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 452652010424 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652010425 dimer interface [polypeptide binding]; other site 452652010426 conserved gate region; other site 452652010427 putative PBP binding loops; other site 452652010428 ABC-ATPase subunit interface; other site 452652010429 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 452652010430 beta-galactosidase; Region: BGL; TIGR03356 452652010431 AAA ATPase domain; Region: AAA_16; pfam13191 452652010432 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 452652010433 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 452652010434 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 452652010435 active site 452652010436 Phosphotransferase enzyme family; Region: APH; pfam01636 452652010437 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 452652010438 Catalytic domain of Protein Kinases; Region: PKc; cd00180 452652010439 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 452652010440 active site 452652010441 ATP binding site [chemical binding]; other site 452652010442 substrate binding site [chemical binding]; other site 452652010443 activation loop (A-loop); other site 452652010444 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 452652010445 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 452652010446 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652010447 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452652010448 DNA binding residues [nucleotide binding] 452652010449 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 452652010450 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452652010451 Coenzyme A binding pocket [chemical binding]; other site 452652010452 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 452652010453 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 452652010454 active site 452652010455 catalytic residues [active] 452652010456 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 452652010457 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 452652010458 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 452652010459 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 452652010460 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 452652010461 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 452652010462 motif II; other site 452652010463 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 452652010464 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 452652010465 hydrophobic ligand binding site; other site 452652010466 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652010467 NADH(P)-binding; Region: NAD_binding_10; pfam13460 452652010468 NAD(P) binding site [chemical binding]; other site 452652010469 active site 452652010470 Uncharacterized conserved protein [Function unknown]; Region: COG2128 452652010471 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 452652010472 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 452652010473 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 452652010474 DNA-binding site [nucleotide binding]; DNA binding site 452652010475 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 452652010476 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652010477 homodimer interface [polypeptide binding]; other site 452652010478 catalytic residue [active] 452652010479 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 452652010480 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652010481 non-specific DNA binding site [nucleotide binding]; other site 452652010482 salt bridge; other site 452652010483 sequence-specific DNA binding site [nucleotide binding]; other site 452652010484 Cupin domain; Region: Cupin_2; pfam07883 452652010485 pyruvate dehydrogenase; Provisional; Region: PRK06546 452652010486 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 452652010487 PYR/PP interface [polypeptide binding]; other site 452652010488 tetramer interface [polypeptide binding]; other site 452652010489 dimer interface [polypeptide binding]; other site 452652010490 TPP binding site [chemical binding]; other site 452652010491 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 452652010492 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 452652010493 TPP-binding site [chemical binding]; other site 452652010494 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 452652010495 Cytochrome P450; Region: p450; cl12078 452652010496 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 452652010497 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 452652010498 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 452652010499 G1 box; other site 452652010500 GTP/Mg2+ binding site [chemical binding]; other site 452652010501 G2 box; other site 452652010502 Switch I region; other site 452652010503 G3 box; other site 452652010504 Switch II region; other site 452652010505 G4 box; other site 452652010506 G5 box; other site 452652010507 Protein of unknown function (DUF742); Region: DUF742; pfam05331 452652010508 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 452652010509 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652010510 ATP binding site [chemical binding]; other site 452652010511 Mg2+ binding site [ion binding]; other site 452652010512 G-X-G motif; other site 452652010513 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452652010514 PAS fold; Region: PAS_3; pfam08447 452652010515 putative active site [active] 452652010516 heme pocket [chemical binding]; other site 452652010517 GAF domain; Region: GAF_3; pfam13492 452652010518 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 452652010519 WHG domain; Region: WHG; pfam13305 452652010520 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 452652010521 yiaA/B two helix domain; Region: YiaAB; cl01759 452652010522 Peptidase family M23; Region: Peptidase_M23; pfam01551 452652010523 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 452652010524 Putative sensor; Region: Sensor; pfam13796 452652010525 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 452652010526 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 452652010527 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 452652010528 DNA binding residues [nucleotide binding] 452652010529 putative dimer interface [polypeptide binding]; other site 452652010530 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 452652010531 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652010532 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 452652010533 nudix motif; other site 452652010534 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652010535 non-specific DNA binding site [nucleotide binding]; other site 452652010536 salt bridge; other site 452652010537 sequence-specific DNA binding site [nucleotide binding]; other site 452652010538 methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188 452652010539 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652010540 S-adenosylmethionine binding site [chemical binding]; other site 452652010541 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 452652010542 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 452652010543 catalytic residues [active] 452652010544 catalytic nucleophile [active] 452652010545 Recombinase; Region: Recombinase; pfam07508 452652010546 Winged helix-turn helix; Region: HTH_29; pfam13551 452652010547 Winged helix-turn helix; Region: HTH_33; pfam13592 452652010548 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 452652010549 DDE superfamily endonuclease; Region: DDE_3; pfam13358 452652010550 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 452652010551 active site 452652010552 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652010553 sequence-specific DNA binding site [nucleotide binding]; other site 452652010554 salt bridge; other site 452652010555 methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188 452652010556 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652010557 S-adenosylmethionine binding site [chemical binding]; other site 452652010558 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 452652010559 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 452652010560 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 452652010561 putative active site [active] 452652010562 putative NTP binding site [chemical binding]; other site 452652010563 putative nucleic acid binding site [nucleotide binding]; other site 452652010564 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 452652010565 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 452652010566 active site 452652010567 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 452652010568 Protease prsW family; Region: PrsW-protease; pfam13367 452652010569 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 452652010570 Predicted dehydrogenase [General function prediction only]; Region: COG0579 452652010571 hydroxyglutarate oxidase; Provisional; Region: PRK11728 452652010572 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 452652010573 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 452652010574 Ligand Binding Site [chemical binding]; other site 452652010575 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 452652010576 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 452652010577 catalytic residues [active] 452652010578 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 452652010579 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652010580 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 452652010581 NPCBM/NEW2 domain; Region: NPCBM; cl07060 452652010582 Proteins of 100 residues with WXG; Region: WXG100; cl02005 452652010583 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 452652010584 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 452652010585 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 452652010586 PAS fold; Region: PAS_4; pfam08448 452652010587 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 452652010588 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 452652010589 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452652010590 Coenzyme A binding pocket [chemical binding]; other site 452652010591 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452652010592 Coenzyme A binding pocket [chemical binding]; other site 452652010593 polyphosphate kinase; Provisional; Region: PRK05443 452652010594 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 452652010595 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 452652010596 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 452652010597 putative domain interface [polypeptide binding]; other site 452652010598 putative active site [active] 452652010599 catalytic site [active] 452652010600 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 452652010601 putative domain interface [polypeptide binding]; other site 452652010602 putative active site [active] 452652010603 catalytic site [active] 452652010604 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 452652010605 active site 452652010606 Ap6A binding site [chemical binding]; other site 452652010607 nudix motif; other site 452652010608 metal binding site [ion binding]; metal-binding site 452652010609 PBP superfamily domain; Region: PBP_like_2; cl17296 452652010610 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 452652010611 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652010612 dimer interface [polypeptide binding]; other site 452652010613 conserved gate region; other site 452652010614 putative PBP binding loops; other site 452652010615 ABC-ATPase subunit interface; other site 452652010616 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 452652010617 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652010618 dimer interface [polypeptide binding]; other site 452652010619 conserved gate region; other site 452652010620 putative PBP binding loops; other site 452652010621 ABC-ATPase subunit interface; other site 452652010622 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 452652010623 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 452652010624 Walker A/P-loop; other site 452652010625 ATP binding site [chemical binding]; other site 452652010626 Q-loop/lid; other site 452652010627 ABC transporter signature motif; other site 452652010628 Walker B; other site 452652010629 D-loop; other site 452652010630 H-loop/switch region; other site 452652010631 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 452652010632 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 452652010633 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 452652010634 putative homotetramer interface [polypeptide binding]; other site 452652010635 putative homodimer interface [polypeptide binding]; other site 452652010636 putative allosteric switch controlling residues; other site 452652010637 putative metal binding site [ion binding]; other site 452652010638 putative homodimer-homodimer interface [polypeptide binding]; other site 452652010639 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 452652010640 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 452652010641 active site 452652010642 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 452652010643 N-acetyl-D-glucosamine binding site [chemical binding]; other site 452652010644 catalytic residue [active] 452652010645 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 452652010646 NlpC/P60 family; Region: NLPC_P60; pfam00877 452652010647 AAA-like domain; Region: AAA_10; pfam12846 452652010648 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 452652010649 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 452652010650 putative active site [active] 452652010651 putative metal binding site [ion binding]; other site 452652010652 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 452652010653 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452652010654 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 452652010655 dimerization interface [polypeptide binding]; other site 452652010656 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452652010657 dimer interface [polypeptide binding]; other site 452652010658 phosphorylation site [posttranslational modification] 452652010659 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652010660 ATP binding site [chemical binding]; other site 452652010661 Mg2+ binding site [ion binding]; other site 452652010662 G-X-G motif; other site 452652010663 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 452652010664 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652010665 active site 452652010666 phosphorylation site [posttranslational modification] 452652010667 intermolecular recognition site; other site 452652010668 dimerization interface [polypeptide binding]; other site 452652010669 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 452652010670 DNA binding site [nucleotide binding] 452652010671 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 452652010672 Transcriptional regulators [Transcription]; Region: PurR; COG1609 452652010673 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 452652010674 DNA binding site [nucleotide binding] 452652010675 domain linker motif; other site 452652010676 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 452652010677 dimerization interface [polypeptide binding]; other site 452652010678 ligand binding site [chemical binding]; other site 452652010679 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 452652010680 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 452652010681 DNA binding site [nucleotide binding] 452652010682 Ubiquitin-like proteins; Region: UBQ; cl00155 452652010683 charged pocket; other site 452652010684 hydrophobic patch; other site 452652010685 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 452652010686 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 452652010687 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 452652010688 active site residue [active] 452652010689 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 452652010690 active site residue [active] 452652010691 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 452652010692 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 452652010693 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 452652010694 heme-binding site [chemical binding]; other site 452652010695 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 452652010696 metal binding site 2 [ion binding]; metal-binding site 452652010697 putative DNA binding helix; other site 452652010698 metal binding site 1 [ion binding]; metal-binding site 452652010699 dimer interface [polypeptide binding]; other site 452652010700 structural Zn2+ binding site [ion binding]; other site 452652010701 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 452652010702 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 452652010703 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 452652010704 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 452652010705 putative active site [active] 452652010706 dimerization interface [polypeptide binding]; other site 452652010707 putative tRNAtyr binding site [nucleotide binding]; other site 452652010708 L-asparaginase II; Region: Asparaginase_II; pfam06089 452652010709 Dodecin; Region: Dodecin; pfam07311 452652010710 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 452652010711 dimer interface [polypeptide binding]; other site 452652010712 substrate binding site [chemical binding]; other site 452652010713 metal binding sites [ion binding]; metal-binding site 452652010714 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 452652010715 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 452652010716 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 452652010717 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 452652010718 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 452652010719 Ligand Binding Site [chemical binding]; other site 452652010720 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 452652010721 active site 452652010722 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 452652010723 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452652010724 Walker A motif; other site 452652010725 ATP binding site [chemical binding]; other site 452652010726 Walker B motif; other site 452652010727 arginine finger; other site 452652010728 Peptidase family M41; Region: Peptidase_M41; pfam01434 452652010729 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 452652010730 homodecamer interface [polypeptide binding]; other site 452652010731 GTP cyclohydrolase I; Provisional; Region: PLN03044 452652010732 active site 452652010733 putative catalytic site residues [active] 452652010734 zinc binding site [ion binding]; other site 452652010735 GTP-CH-I/GFRP interaction surface; other site 452652010736 Putative esterase; Region: Esterase; pfam00756 452652010737 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 452652010738 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 452652010739 dihydropteroate synthase; Region: DHPS; TIGR01496 452652010740 substrate binding pocket [chemical binding]; other site 452652010741 dimer interface [polypeptide binding]; other site 452652010742 inhibitor binding site; inhibition site 452652010743 SnoaL-like domain; Region: SnoaL_3; pfam13474 452652010744 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 452652010745 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 452652010746 homooctamer interface [polypeptide binding]; other site 452652010747 active site 452652010748 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 452652010749 catalytic center binding site [active] 452652010750 ATP binding site [chemical binding]; other site 452652010751 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 452652010752 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 452652010753 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 452652010754 putative metal binding site [ion binding]; other site 452652010755 hypothetical protein; Provisional; Region: PRK09256 452652010756 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 452652010757 GAF domain; Region: GAF; cl17456 452652010758 PAS domain S-box; Region: sensory_box; TIGR00229 452652010759 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452652010760 putative active site [active] 452652010761 heme pocket [chemical binding]; other site 452652010762 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 452652010763 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 452652010764 metal binding site [ion binding]; metal-binding site 452652010765 active site 452652010766 I-site; other site 452652010767 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 452652010768 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 452652010769 intersubunit interface [polypeptide binding]; other site 452652010770 active site 452652010771 zinc binding site [ion binding]; other site 452652010772 Na+ binding site [ion binding]; other site 452652010773 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 452652010774 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 452652010775 active site 452652010776 dimer interface [polypeptide binding]; other site 452652010777 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 452652010778 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 452652010779 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 452652010780 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 452652010781 dimer interface [polypeptide binding]; other site 452652010782 active site 452652010783 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 452652010784 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 452652010785 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 452652010786 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 452652010787 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 452652010788 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 452652010789 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 452652010790 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 452652010791 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 452652010792 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 452652010793 active site 452652010794 homotetramer interface [polypeptide binding]; other site 452652010795 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 452652010796 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 452652010797 threonine synthase; Validated; Region: PRK07591 452652010798 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 452652010799 homodimer interface [polypeptide binding]; other site 452652010800 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652010801 catalytic residue [active] 452652010802 charged pocket; other site 452652010803 ThiS family; Region: ThiS; pfam02597 452652010804 hydrophobic patch; other site 452652010805 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 452652010806 DNA-binding site [nucleotide binding]; DNA binding site 452652010807 RNA-binding motif; other site 452652010808 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 452652010809 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 452652010810 ring oligomerisation interface [polypeptide binding]; other site 452652010811 ATP/Mg binding site [chemical binding]; other site 452652010812 stacking interactions; other site 452652010813 hinge regions; other site 452652010814 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 452652010815 putative active site [active] 452652010816 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 452652010817 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 452652010818 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 452652010819 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 452652010820 Walker A/P-loop; other site 452652010821 ATP binding site [chemical binding]; other site 452652010822 Q-loop/lid; other site 452652010823 ABC transporter signature motif; other site 452652010824 Walker B; other site 452652010825 D-loop; other site 452652010826 H-loop/switch region; other site 452652010827 Predicted transcriptional regulators [Transcription]; Region: COG1695 452652010828 Transcriptional regulator PadR-like family; Region: PadR; cl17335 452652010829 CutC family; Region: CutC; cl01218 452652010830 Part of AAA domain; Region: AAA_19; pfam13245 452652010831 Family description; Region: UvrD_C_2; pfam13538 452652010832 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 452652010833 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 452652010834 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 452652010835 ATP binding site [chemical binding]; other site 452652010836 putative Mg++ binding site [ion binding]; other site 452652010837 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 452652010838 nucleotide binding region [chemical binding]; other site 452652010839 ATP-binding site [chemical binding]; other site 452652010840 Predicted membrane protein [Function unknown]; Region: COG3463 452652010841 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 452652010842 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 452652010843 WYL domain; Region: WYL; pfam13280 452652010844 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 452652010845 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 452652010846 intersubunit interface [polypeptide binding]; other site 452652010847 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 452652010848 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 452652010849 Predicted esterase [General function prediction only]; Region: COG0627 452652010850 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 452652010851 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 452652010852 DNA-binding site [nucleotide binding]; DNA binding site 452652010853 RNA-binding motif; other site 452652010854 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 452652010855 hypothetical protein; Provisional; Region: PRK08236 452652010856 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 452652010857 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 452652010858 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 452652010859 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 452652010860 Soluble P-type ATPase [General function prediction only]; Region: COG4087 452652010861 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 452652010862 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 452652010863 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 452652010864 nudix motif; other site 452652010865 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452652010866 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452652010867 TPR motif; other site 452652010868 binding surface 452652010869 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452652010870 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 452652010871 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 452652010872 putative active site [active] 452652010873 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 452652010874 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 452652010875 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 452652010876 phosphopeptide binding site; other site 452652010877 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 452652010878 MarR family; Region: MarR; pfam01047 452652010879 H+ Antiporter protein; Region: 2A0121; TIGR00900 452652010880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652010881 putative substrate translocation pore; other site 452652010882 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452652010883 Coenzyme A binding pocket [chemical binding]; other site 452652010884 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 452652010885 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 452652010886 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 452652010887 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652010888 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652010889 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652010890 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 452652010891 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652010892 active site 452652010893 phosphorylation site [posttranslational modification] 452652010894 intermolecular recognition site; other site 452652010895 dimerization interface [polypeptide binding]; other site 452652010896 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 452652010897 DNA binding site [nucleotide binding] 452652010898 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 452652010899 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 452652010900 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652010901 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 452652010902 NAD(P) binding site [chemical binding]; other site 452652010903 active site 452652010904 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652010905 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 452652010906 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 452652010907 active site 452652010908 catalytic tetrad [active] 452652010909 FAD binding domain; Region: FAD_binding_3; pfam01494 452652010910 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 452652010911 short chain dehydrogenase; Provisional; Region: PRK12747 452652010912 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652010913 NAD(P) binding site [chemical binding]; other site 452652010914 active site 452652010915 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 452652010916 MarR family; Region: MarR; pfam01047 452652010917 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 452652010918 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 452652010919 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 452652010920 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 452652010921 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 452652010922 catalytic residue [active] 452652010923 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 452652010924 dimer interface [polypeptide binding]; other site 452652010925 Citrate synthase; Region: Citrate_synt; pfam00285 452652010926 active site 452652010927 citrylCoA binding site [chemical binding]; other site 452652010928 oxalacetate/citrate binding site [chemical binding]; other site 452652010929 coenzyme A binding site [chemical binding]; other site 452652010930 catalytic triad [active] 452652010931 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 452652010932 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 452652010933 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 452652010934 radical SAM/SPASM domain, FxsB family; Region: SAM_SPASM_FxsB; TIGR04269 452652010935 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 452652010936 FeS/SAM binding site; other site 452652010937 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 452652010938 HEXXH motif domain; Region: mod_HExxH; TIGR04267 452652010939 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 452652010940 TIR domain; Region: TIR_2; pfam13676 452652010941 FxsC C-terminal domain; Region: FxsC_Cterm; TIGR04276 452652010942 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 452652010943 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 452652010944 P-loop; other site 452652010945 Magnesium ion binding site [ion binding]; other site 452652010946 TIR domain; Region: TIR_2; pfam13676 452652010947 NB-ARC domain; Region: NB-ARC; pfam00931 452652010948 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452652010949 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452652010950 Tetratricopeptide repeat; Region: TPR_10; pfam13374 452652010951 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452652010952 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452652010953 binding surface 452652010954 TPR motif; other site 452652010955 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452652010956 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452652010957 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452652010958 Tetratricopeptide repeat; Region: TPR_10; pfam13374 452652010959 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 452652010960 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 452652010961 hypothetical protein; Provisional; Region: PRK02947 452652010962 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 452652010963 putative active site [active] 452652010964 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 452652010965 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 452652010966 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 452652010967 FeoA domain; Region: FeoA; pfam04023 452652010968 Bifunctional DNA primase/polymerase, N-terminal; Region: Prim-Pol; pfam09250 452652010969 nucleotide binding site [chemical binding]; other site 452652010970 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 452652010971 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 452652010972 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 452652010973 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 452652010974 putative active site [active] 452652010975 putative substrate binding site [chemical binding]; other site 452652010976 putative cosubstrate binding site; other site 452652010977 catalytic site [active] 452652010978 H+ Antiporter protein; Region: 2A0121; TIGR00900 452652010979 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652010980 Major Facilitator Superfamily; Region: MFS_1; pfam07690 452652010981 putative substrate translocation pore; other site 452652010982 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 452652010983 Transcriptional regulators [Transcription]; Region: PurR; COG1609 452652010984 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 452652010985 DNA binding site [nucleotide binding] 452652010986 domain linker motif; other site 452652010987 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 452652010988 dimerization interface [polypeptide binding]; other site 452652010989 ligand binding site [chemical binding]; other site 452652010990 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 452652010991 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 452652010992 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 452652010993 putative active site [active] 452652010994 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 452652010995 DNA-binding site [nucleotide binding]; DNA binding site 452652010996 RNA-binding motif; other site 452652010997 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 452652010998 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 452652010999 Catalytic domain of Protein Kinases; Region: PKc; cd00180 452652011000 active site 452652011001 ATP binding site [chemical binding]; other site 452652011002 substrate binding site [chemical binding]; other site 452652011003 activation loop (A-loop); other site 452652011004 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 452652011005 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 452652011006 FeS/SAM binding site; other site 452652011007 guanine deaminase; Provisional; Region: PRK09228 452652011008 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 452652011009 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 452652011010 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 452652011011 putative active site [active] 452652011012 Hyaluronidase; Region: Glyco_hydro_56; pfam01630 452652011013 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 452652011014 sugar binding site [chemical binding]; other site 452652011015 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 452652011016 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 452652011017 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 452652011018 putative active site [active] 452652011019 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 452652011020 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 452652011021 substrate binding pocket [chemical binding]; other site 452652011022 membrane-bound complex binding site; other site 452652011023 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 452652011024 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652011025 putative PBP binding loops; other site 452652011026 ABC-ATPase subunit interface; other site 452652011027 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 452652011028 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652011029 Walker A/P-loop; other site 452652011030 ATP binding site [chemical binding]; other site 452652011031 Q-loop/lid; other site 452652011032 ABC transporter signature motif; other site 452652011033 Walker B; other site 452652011034 D-loop; other site 452652011035 H-loop/switch region; other site 452652011036 Protein of unknown function (DUF4427); Region: DUF4427; pfam14468 452652011037 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 452652011038 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652011039 S-adenosylmethionine binding site [chemical binding]; other site 452652011040 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 452652011041 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 452652011042 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 452652011043 putative active site [active] 452652011044 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 452652011045 EamA-like transporter family; Region: EamA; pfam00892 452652011046 NADH dehydrogenase subunit A; Validated; Region: PRK07928 452652011047 NADH dehydrogenase subunit B; Validated; Region: PRK06411 452652011048 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 452652011049 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 452652011050 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 452652011051 NADH dehydrogenase subunit D; Validated; Region: PRK06075 452652011052 NADH dehydrogenase subunit E; Validated; Region: PRK07539 452652011053 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 452652011054 putative dimer interface [polypeptide binding]; other site 452652011055 [2Fe-2S] cluster binding site [ion binding]; other site 452652011056 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 452652011057 SLBB domain; Region: SLBB; pfam10531 452652011058 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 452652011059 NADH dehydrogenase subunit G; Validated; Region: PRK07860 452652011060 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 452652011061 catalytic loop [active] 452652011062 iron binding site [ion binding]; other site 452652011063 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 452652011064 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 452652011065 molybdopterin cofactor binding site; other site 452652011066 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 452652011067 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 452652011068 molybdopterin cofactor binding site; other site 452652011069 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 452652011070 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 452652011071 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 452652011072 4Fe-4S binding domain; Region: Fer4; pfam00037 452652011073 4Fe-4S binding domain; Region: Fer4; pfam00037 452652011074 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 452652011075 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 452652011076 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 452652011077 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 452652011078 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 452652011079 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 452652011080 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 452652011081 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 452652011082 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 452652011083 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 452652011084 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 452652011085 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 452652011086 substrate binding pocket [chemical binding]; other site 452652011087 chain length determination region; other site 452652011088 substrate-Mg2+ binding site; other site 452652011089 catalytic residues [active] 452652011090 aspartate-rich region 1; other site 452652011091 active site lid residues [active] 452652011092 aspartate-rich region 2; other site 452652011093 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652011094 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652011095 active site 452652011096 phosphorylation site [posttranslational modification] 452652011097 intermolecular recognition site; other site 452652011098 dimerization interface [polypeptide binding]; other site 452652011099 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652011100 DNA binding residues [nucleotide binding] 452652011101 dimerization interface [polypeptide binding]; other site 452652011102 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 452652011103 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 452652011104 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 452652011105 dimer interface [polypeptide binding]; other site 452652011106 PYR/PP interface [polypeptide binding]; other site 452652011107 TPP binding site [chemical binding]; other site 452652011108 substrate binding site [chemical binding]; other site 452652011109 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 452652011110 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 452652011111 TPP-binding site [chemical binding]; other site 452652011112 Predicted permeases [General function prediction only]; Region: RarD; COG2962 452652011113 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 452652011114 FO synthase; Reviewed; Region: fbiC; PRK09234 452652011115 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 452652011116 FeS/SAM binding site; other site 452652011117 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 452652011118 FeS/SAM binding site; other site 452652011119 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 452652011120 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 452652011121 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 452652011122 Domain of unknown function (DUF397); Region: DUF397; pfam04149 452652011123 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652011124 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 452652011125 sequence-specific DNA binding site [nucleotide binding]; other site 452652011126 salt bridge; other site 452652011127 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 452652011128 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 452652011129 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 452652011130 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 452652011131 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 452652011132 Ligand binding site; other site 452652011133 Putative Catalytic site; other site 452652011134 DXD motif; other site 452652011135 potential frameshift: common BLAST hit: gi|336179586|ref|YP_004584961.1| transposase mutator type 452652011136 Transposase, Mutator family; Region: Transposase_mut; pfam00872 452652011137 Transposase, Mutator family; Region: Transposase_mut; pfam00872 452652011138 Helix-turn-helix domain; Region: HTH_31; pfam13560 452652011139 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452652011140 NACHT domain; Region: NACHT; pfam05729 452652011141 Walker A motif; other site 452652011142 ATP binding site [chemical binding]; other site 452652011143 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 452652011144 Uncharacterized conserved protein [Function unknown]; Region: COG5323 452652011145 Domain of unknown function DUF20; Region: UPF0118; pfam01594 452652011146 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 452652011147 HPP family; Region: HPP; pfam04982 452652011148 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 452652011149 ABC-2 type transporter; Region: ABC2_membrane; cl17235 452652011150 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 452652011151 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 452652011152 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 452652011153 Walker A/P-loop; other site 452652011154 ATP binding site [chemical binding]; other site 452652011155 Q-loop/lid; other site 452652011156 ABC transporter signature motif; other site 452652011157 Walker B; other site 452652011158 D-loop; other site 452652011159 H-loop/switch region; other site 452652011160 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 452652011161 Cytochrome P450; Region: p450; cl12078 452652011162 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 452652011163 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 452652011164 putative active site [active] 452652011165 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652011166 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 452652011167 Walker A/P-loop; other site 452652011168 ATP binding site [chemical binding]; other site 452652011169 Q-loop/lid; other site 452652011170 ABC transporter signature motif; other site 452652011171 Walker B; other site 452652011172 D-loop; other site 452652011173 H-loop/switch region; other site 452652011174 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652011175 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 452652011176 Walker A/P-loop; other site 452652011177 ATP binding site [chemical binding]; other site 452652011178 Q-loop/lid; other site 452652011179 ABC transporter signature motif; other site 452652011180 Walker B; other site 452652011181 D-loop; other site 452652011182 H-loop/switch region; other site 452652011183 Domain of unknown function (DUF4135); Region: DUF4135; pfam13575 452652011184 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 452652011185 YcaO-like family; Region: YcaO; pfam02624 452652011186 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 452652011187 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 452652011188 putative FMN binding site [chemical binding]; other site 452652011189 NADPH bind site [chemical binding]; other site 452652011190 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652011191 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652011192 DNA binding residues [nucleotide binding] 452652011193 dimerization interface [polypeptide binding]; other site 452652011194 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 452652011195 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652011196 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 452652011197 DNA binding residues [nucleotide binding] 452652011198 dimerization interface [polypeptide binding]; other site 452652011199 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 452652011200 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 452652011201 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 452652011202 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652011203 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 452652011204 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452652011205 DNA binding residues [nucleotide binding] 452652011206 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 452652011207 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 452652011208 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 452652011209 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 452652011210 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 452652011211 TrkA-C domain; Region: TrkA_C; pfam02080 452652011212 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 452652011213 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 452652011214 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 452652011215 active site 452652011216 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 452652011217 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 452652011218 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 452652011219 metal binding site [ion binding]; metal-binding site 452652011220 active site 452652011221 I-site; other site 452652011222 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 452652011223 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 452652011224 active site 452652011225 tetramer interface; other site 452652011226 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 452652011227 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 452652011228 dimer interface [polypeptide binding]; other site 452652011229 putative functional site; other site 452652011230 putative MPT binding site; other site 452652011231 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 452652011232 trimer interface [polypeptide binding]; other site 452652011233 dimer interface [polypeptide binding]; other site 452652011234 putative active site [active] 452652011235 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 452652011236 MPT binding site; other site 452652011237 trimer interface [polypeptide binding]; other site 452652011238 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 452652011239 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 452652011240 Glutaminase; Region: Glutaminase; cl00907 452652011241 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 452652011242 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 452652011243 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 452652011244 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 452652011245 PhnA protein; Region: PhnA; pfam03831 452652011246 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 452652011247 dimerization interface [polypeptide binding]; other site 452652011248 putative DNA binding site [nucleotide binding]; other site 452652011249 putative Zn2+ binding site [ion binding]; other site 452652011250 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 452652011251 Sulfate transporter family; Region: Sulfate_transp; pfam00916 452652011252 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 452652011253 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 452652011254 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 452652011255 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 452652011256 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 452652011257 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652011258 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652011259 active site 452652011260 phosphorylation site [posttranslational modification] 452652011261 intermolecular recognition site; other site 452652011262 dimerization interface [polypeptide binding]; other site 452652011263 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652011264 DNA binding residues [nucleotide binding] 452652011265 dimerization interface [polypeptide binding]; other site 452652011266 Putative sensor; Region: Sensor; pfam13796 452652011267 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 452652011268 Histidine kinase; Region: HisKA_3; pfam07730 452652011269 CAAX protease self-immunity; Region: Abi; pfam02517 452652011270 Non-plant Terpene Cyclases, Class 1; Region: Terpene_cyclase_nonplant_C1; cd00687 452652011271 substrate binding pocket [chemical binding]; other site 452652011272 substrate-Mg2+ binding site; other site 452652011273 aspartate-rich region 1; other site 452652011274 active site lid residues [active] 452652011275 aspartate-rich region 2; other site 452652011276 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 452652011277 substrate binding pocket [chemical binding]; other site 452652011278 substrate-Mg2+ binding site; other site 452652011279 aspartate-rich region 1; other site 452652011280 aspartate-rich region 2; other site 452652011281 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 452652011282 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 452652011283 metal ion-dependent adhesion site (MIDAS); other site 452652011284 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 452652011285 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652011286 Walker A/P-loop; other site 452652011287 ATP binding site [chemical binding]; other site 452652011288 Q-loop/lid; other site 452652011289 ABC transporter signature motif; other site 452652011290 Walker B; other site 452652011291 D-loop; other site 452652011292 H-loop/switch region; other site 452652011293 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652011294 Major Facilitator Superfamily; Region: MFS_1; pfam07690 452652011295 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 452652011296 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 452652011297 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 452652011298 amino acid transporter; Region: 2A0306; TIGR00909 452652011299 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 452652011300 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 452652011301 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 452652011302 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 452652011303 Predicted methyltransferases [General function prediction only]; Region: COG0313 452652011304 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 452652011305 putative SAM binding site [chemical binding]; other site 452652011306 putative homodimer interface [polypeptide binding]; other site 452652011307 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 452652011308 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 452652011309 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 452652011310 active site 452652011311 HIGH motif; other site 452652011312 KMSKS motif; other site 452652011313 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 452652011314 tRNA binding surface [nucleotide binding]; other site 452652011315 anticodon binding site; other site 452652011316 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 452652011317 active site 452652011318 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 452652011319 putative active site [active] 452652011320 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 452652011321 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652011322 S-adenosylmethionine binding site [chemical binding]; other site 452652011323 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 452652011324 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 452652011325 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 452652011326 active site 452652011327 catalytic tetrad [active] 452652011328 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 452652011329 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 452652011330 ABC transporter; Region: ABC_tran_2; pfam12848 452652011331 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 452652011332 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 452652011333 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 452652011334 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 452652011335 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 452652011336 NAD binding site [chemical binding]; other site 452652011337 homodimer interface [polypeptide binding]; other site 452652011338 active site 452652011339 substrate binding site [chemical binding]; other site 452652011340 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652011341 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652011342 DNA binding residues [nucleotide binding] 452652011343 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 452652011344 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 452652011345 NAD(P) binding site [chemical binding]; other site 452652011346 homodimer interface [polypeptide binding]; other site 452652011347 substrate binding site [chemical binding]; other site 452652011348 active site 452652011349 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 452652011350 MarR family; Region: MarR_2; cl17246 452652011351 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 452652011352 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652011353 S-adenosylmethionine binding site [chemical binding]; other site 452652011354 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652011355 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652011356 Fatty acid desaturase; Region: FA_desaturase; pfam00487 452652011357 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 452652011358 Di-iron ligands [ion binding]; other site 452652011359 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 452652011360 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 452652011361 Substrate binding site; other site 452652011362 Mg++ binding site; other site 452652011363 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 452652011364 active site 452652011365 substrate binding site [chemical binding]; other site 452652011366 CoA binding site [chemical binding]; other site 452652011367 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 452652011368 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 452652011369 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 452652011370 active site 452652011371 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 452652011372 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 452652011373 5S rRNA interface [nucleotide binding]; other site 452652011374 CTC domain interface [polypeptide binding]; other site 452652011375 L16 interface [polypeptide binding]; other site 452652011376 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 452652011377 putative active site [active] 452652011378 catalytic residue [active] 452652011379 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652011380 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652011381 DNA binding residues [nucleotide binding] 452652011382 dimerization interface [polypeptide binding]; other site 452652011383 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 452652011384 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 452652011385 Walker A/P-loop; other site 452652011386 ATP binding site [chemical binding]; other site 452652011387 Q-loop/lid; other site 452652011388 ABC transporter signature motif; other site 452652011389 Walker B; other site 452652011390 D-loop; other site 452652011391 H-loop/switch region; other site 452652011392 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452652011393 FtsX-like permease family; Region: FtsX; pfam02687 452652011394 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 452652011395 Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311 452652011396 Histidine kinase; Region: HisKA_3; pfam07730 452652011397 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 452652011398 SUKH-3 immunity protein; Region: SUKH-3; pfam14433 452652011399 YwqJ-like deaminase; Region: YwqJ-deaminase; pfam14431 452652011400 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 452652011401 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 452652011402 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 452652011403 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652011404 NAD(P) binding site [chemical binding]; other site 452652011405 active site 452652011406 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 452652011407 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 452652011408 inhibitor-cofactor binding pocket; inhibition site 452652011409 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652011410 catalytic residue [active] 452652011411 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 452652011412 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 452652011413 inhibitor-cofactor binding pocket; inhibition site 452652011414 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652011415 catalytic residue [active] 452652011416 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 452652011417 Xanthomonas XOO_2897-like deaminase; Region: XOO_2897-deam; pfam14440 452652011418 SUKH-4 immunity protein; Region: SUKH-4; pfam14435 452652011419 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 452652011420 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652011421 NAD(P) binding site [chemical binding]; other site 452652011422 active site 452652011423 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 452652011424 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 452652011425 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 452652011426 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 452652011427 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 452652011428 ATP binding site [chemical binding]; other site 452652011429 putative Mg++ binding site [ion binding]; other site 452652011430 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 452652011431 nucleotide binding region [chemical binding]; other site 452652011432 ATP-binding site [chemical binding]; other site 452652011433 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 452652011434 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 452652011435 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 452652011436 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 452652011437 Catalytic domain of Protein Kinases; Region: PKc; cd00180 452652011438 active site 452652011439 ATP binding site [chemical binding]; other site 452652011440 substrate binding site [chemical binding]; other site 452652011441 activation loop (A-loop); other site 452652011442 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 452652011443 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 452652011444 active site 452652011445 conserved repeat domain; Region: B_ant_repeat; TIGR01451 452652011446 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 452652011447 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 452652011448 homodimer interface [polypeptide binding]; other site 452652011449 metal binding site [ion binding]; metal-binding site 452652011450 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652011451 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 452652011452 Cytochrome P450; Region: p450; cl12078 452652011453 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 452652011454 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 452652011455 enolase; Provisional; Region: eno; PRK00077 452652011456 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 452652011457 dimer interface [polypeptide binding]; other site 452652011458 metal binding site [ion binding]; metal-binding site 452652011459 substrate binding pocket [chemical binding]; other site 452652011460 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 452652011461 Septum formation initiator; Region: DivIC; pfam04977 452652011462 Protein of unknown function (DUF501); Region: DUF501; pfam04417 452652011463 exopolyphosphatase; Region: exo_poly_only; TIGR03706 452652011464 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 452652011465 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 452652011466 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 452652011467 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 452652011468 active site 452652011469 nudix motif; other site 452652011470 ADP-ribose binding site [chemical binding]; other site 452652011471 metal binding site [ion binding]; metal-binding site 452652011472 dimer interface [polypeptide binding]; other site 452652011473 Sulfatase; Region: Sulfatase; cl17466 452652011474 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 452652011475 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 452652011476 Radical SAM superfamily; Region: Radical_SAM; pfam04055 452652011477 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 452652011478 FeS/SAM binding site; other site 452652011479 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652011480 non-specific DNA binding site [nucleotide binding]; other site 452652011481 salt bridge; other site 452652011482 sequence-specific DNA binding site [nucleotide binding]; other site 452652011483 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 452652011484 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 452652011485 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 452652011486 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652011487 NAD(P) binding site [chemical binding]; other site 452652011488 active site 452652011489 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 452652011490 nudix motif; other site 452652011491 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 452652011492 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652011493 ATP binding site [chemical binding]; other site 452652011494 Mg2+ binding site [ion binding]; other site 452652011495 G-X-G motif; other site 452652011496 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 452652011497 catalytic residues [active] 452652011498 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452652011499 Coenzyme A binding pocket [chemical binding]; other site 452652011500 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 452652011501 methyltransferase, FxLD system; Region: methyltran_FxLD; TIGR04364 452652011502 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 452652011503 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 452652011504 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652011505 S-adenosylmethionine binding site [chemical binding]; other site 452652011506 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 452652011507 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 452652011508 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 452652011509 Ligand Binding Site [chemical binding]; other site 452652011510 Molecular Tunnel; other site 452652011511 Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183 452652011512 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652011513 sequence-specific DNA binding site [nucleotide binding]; other site 452652011514 salt bridge; other site 452652011515 Flavoprotein; Region: Flavoprotein; pfam02441 452652011516 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 452652011517 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 452652011518 Walker A/P-loop; other site 452652011519 ATP binding site [chemical binding]; other site 452652011520 Q-loop/lid; other site 452652011521 ABC transporter signature motif; other site 452652011522 Walker B; other site 452652011523 D-loop; other site 452652011524 H-loop/switch region; other site 452652011525 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452652011526 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 452652011527 FtsX-like permease family; Region: FtsX; pfam02687 452652011528 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452652011529 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 452652011530 FtsX-like permease family; Region: FtsX; pfam02687 452652011531 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 452652011532 active site 452652011533 Bax inhibitor 1 like; Region: BaxI_1; cl17691 452652011534 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 452652011535 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 452652011536 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 452652011537 dimer interface [polypeptide binding]; other site 452652011538 active site 452652011539 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 452652011540 active site 452652011541 catalytic triad [active] 452652011542 oxyanion hole [active] 452652011543 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 452652011544 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 452652011545 dimer interface [polypeptide binding]; other site 452652011546 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652011547 catalytic residue [active] 452652011548 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 452652011549 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 452652011550 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 452652011551 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 452652011552 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 452652011553 mannosyl-3-phosphoglycerate phosphatase; Region: osmo_MPG_phos; TIGR02461 452652011554 Protein of unknown function (DUF1203); Region: DUF1203; pfam06718 452652011555 Cupin domain; Region: Cupin_2; pfam07883 452652011556 cystathionine gamma-synthase; Provisional; Region: PRK07811 452652011557 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 452652011558 homodimer interface [polypeptide binding]; other site 452652011559 substrate-cofactor binding pocket; other site 452652011560 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652011561 catalytic residue [active] 452652011562 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 452652011563 MarR family; Region: MarR; pfam01047 452652011564 threonine dehydratase; Provisional; Region: PRK08198 452652011565 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 452652011566 tetramer interface [polypeptide binding]; other site 452652011567 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652011568 catalytic residue [active] 452652011569 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 452652011570 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652011571 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 452652011572 Walker A/P-loop; other site 452652011573 ATP binding site [chemical binding]; other site 452652011574 Q-loop/lid; other site 452652011575 ABC transporter signature motif; other site 452652011576 Walker B; other site 452652011577 D-loop; other site 452652011578 H-loop/switch region; other site 452652011579 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 452652011580 ABC-2 type transporter; Region: ABC2_membrane; cl17235 452652011581 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 452652011582 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 452652011583 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 452652011584 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 452652011585 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 452652011586 H+ Antiporter protein; Region: 2A0121; TIGR00900 452652011587 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652011588 putative substrate translocation pore; other site 452652011589 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 452652011590 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 452652011591 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452652011592 Helix-turn-helix domain; Region: HTH_18; pfam12833 452652011593 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452652011594 Domain of unknown function (DUF4041); Region: DUF4041; pfam13250 452652011595 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 452652011596 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 452652011597 putative active site [active] 452652011598 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 452652011599 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 452652011600 GIY-YIG motif/motif A; other site 452652011601 active site 452652011602 catalytic site [active] 452652011603 metal binding site [ion binding]; metal-binding site 452652011604 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 452652011605 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 452652011606 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 452652011607 catalytic residues [active] 452652011608 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 452652011609 Predicted acetyltransferase [General function prediction only]; Region: COG3393 452652011610 MarR family; Region: MarR; pfam01047 452652011611 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 452652011612 classical (c) SDRs; Region: SDR_c; cd05233 452652011613 NAD(P) binding site [chemical binding]; other site 452652011614 active site 452652011615 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 452652011616 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 452652011617 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 452652011618 conserved cys residue [active] 452652011619 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452652011620 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 452652011621 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 452652011622 putative NAD(P) binding site [chemical binding]; other site 452652011623 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 452652011624 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652011625 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 452652011626 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 452652011627 Haemolysin-III related; Region: HlyIII; pfam03006 452652011628 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 452652011629 active site 452652011630 substrate-binding site [chemical binding]; other site 452652011631 metal-binding site [ion binding] 452652011632 GTP binding site [chemical binding]; other site 452652011633 aminotransferase AlaT; Validated; Region: PRK09265 452652011634 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 452652011635 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652011636 homodimer interface [polypeptide binding]; other site 452652011637 catalytic residue [active] 452652011638 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 452652011639 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 452652011640 putative active site [active] 452652011641 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 452652011642 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 452652011643 catalytic residue [active] 452652011644 putative FPP diphosphate binding site; other site 452652011645 putative FPP binding hydrophobic cleft; other site 452652011646 dimer interface [polypeptide binding]; other site 452652011647 putative IPP diphosphate binding site; other site 452652011648 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 452652011649 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 452652011650 putative active site [active] 452652011651 PhoH-like protein; Region: PhoH; pfam02562 452652011652 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 452652011653 N-acetyl-D-glucosamine binding site [chemical binding]; other site 452652011654 catalytic residue [active] 452652011655 Domain of unknown function DUF20; Region: UPF0118; pfam01594 452652011656 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 452652011657 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 452652011658 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 452652011659 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 452652011660 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 452652011661 dimer interface [polypeptide binding]; other site 452652011662 decamer (pentamer of dimers) interface [polypeptide binding]; other site 452652011663 catalytic triad [active] 452652011664 peroxidatic and resolving cysteines [active] 452652011665 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 452652011666 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 452652011667 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 452652011668 dimerization interface [polypeptide binding]; other site 452652011669 AAA domain; Region: AAA_23; pfam13476 452652011670 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652011671 Walker A/P-loop; other site 452652011672 ATP binding site [chemical binding]; other site 452652011673 AAA domain; Region: AAA_21; pfam13304 452652011674 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652011675 ABC transporter signature motif; other site 452652011676 Walker B; other site 452652011677 D-loop; other site 452652011678 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 452652011679 active site 452652011680 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 452652011681 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652011682 S-adenosylmethionine binding site [chemical binding]; other site 452652011683 DNA binding site [nucleotide binding] 452652011684 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 452652011685 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 452652011686 NB-ARC domain; Region: NB-ARC; pfam00931 452652011687 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 452652011688 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452652011689 fumarate hydratase; Provisional; Region: PRK15389 452652011690 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 452652011691 Fumarase C-terminus; Region: Fumerase_C; pfam05683 452652011692 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 452652011693 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 452652011694 Transcription factor WhiB; Region: Whib; pfam02467 452652011695 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 452652011696 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 452652011697 putative active site [active] 452652011698 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 452652011699 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 452652011700 putative FMN binding site [chemical binding]; other site 452652011701 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 452652011702 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 452652011703 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452652011704 Coenzyme A binding pocket [chemical binding]; other site 452652011705 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 452652011706 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652011707 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452652011708 DNA binding residues [nucleotide binding] 452652011709 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 452652011710 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 452652011711 generic binding surface II; other site 452652011712 generic binding surface I; other site 452652011713 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 452652011714 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 452652011715 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 452652011716 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 452652011717 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 452652011718 nucleotide binding site [chemical binding]; other site 452652011719 GTP-binding protein YchF; Reviewed; Region: PRK09601 452652011720 YchF GTPase; Region: YchF; cd01900 452652011721 G1 box; other site 452652011722 GTP/Mg2+ binding site [chemical binding]; other site 452652011723 Switch I region; other site 452652011724 G2 box; other site 452652011725 Switch II region; other site 452652011726 G3 box; other site 452652011727 G4 box; other site 452652011728 G5 box; other site 452652011729 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 452652011730 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 452652011731 Uncharacterized conserved protein [Function unknown]; Region: COG3410 452652011732 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 452652011733 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 452652011734 Walker A motif; other site 452652011735 ATP binding site [chemical binding]; other site 452652011736 Walker B motif; other site 452652011737 Uncharacterized conserved protein [Function unknown]; Region: COG3410 452652011738 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 452652011739 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 452652011740 putative active site [active] 452652011741 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652011742 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652011743 WHG domain; Region: WHG; pfam13305 452652011744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652011745 putative substrate translocation pore; other site 452652011746 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 452652011747 putative phosphatase; Provisional; Region: PRK11587 452652011748 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 452652011749 motif II; other site 452652011750 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 452652011751 catalytic motif [active] 452652011752 Zn binding site [ion binding]; other site 452652011753 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 452652011754 RibD C-terminal domain; Region: RibD_C; cl17279 452652011755 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 452652011756 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652011757 S-adenosylmethionine binding site [chemical binding]; other site 452652011758 Clostridium thermocellum (Cth)TTM and similar proteins, a subgroup of the CYTH-like superfamily; Region: CYTH-like_CthTTM-like; cd07761 452652011759 putative active site [active] 452652011760 putative metal binding residues [ion binding]; other site 452652011761 signature motif; other site 452652011762 putative dimer interface [polypeptide binding]; other site 452652011763 putative phosphate binding site [ion binding]; other site 452652011764 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 452652011765 nudix motif; other site 452652011766 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452652011767 PAS domain; Region: PAS_9; pfam13426 452652011768 putative active site [active] 452652011769 heme pocket [chemical binding]; other site 452652011770 PAS fold; Region: PAS_4; pfam08448 452652011771 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452652011772 putative active site [active] 452652011773 heme pocket [chemical binding]; other site 452652011774 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 452652011775 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 452652011776 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 452652011777 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 452652011778 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 452652011779 ATP binding site [chemical binding]; other site 452652011780 Mg2+ binding site [ion binding]; other site 452652011781 G-X-G motif; other site 452652011782 PAS domain; Region: PAS; smart00091 452652011783 PAS fold; Region: PAS_4; pfam08448 452652011784 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452652011785 putative active site [active] 452652011786 heme pocket [chemical binding]; other site 452652011787 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 452652011788 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 452652011789 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 452652011790 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 452652011791 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652011792 ATP binding site [chemical binding]; other site 452652011793 Mg2+ binding site [ion binding]; other site 452652011794 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 452652011795 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 452652011796 G1 box; other site 452652011797 putative GEF interaction site [polypeptide binding]; other site 452652011798 GTP/Mg2+ binding site [chemical binding]; other site 452652011799 Switch I region; other site 452652011800 G2 box; other site 452652011801 G3 box; other site 452652011802 Switch II region; other site 452652011803 G4 box; other site 452652011804 G5 box; other site 452652011805 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 452652011806 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 452652011807 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 452652011808 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 452652011809 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 452652011810 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652011811 conserved gate region; other site 452652011812 putative PBP binding loops; other site 452652011813 ABC-ATPase subunit interface; other site 452652011814 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 452652011815 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652011816 dimer interface [polypeptide binding]; other site 452652011817 conserved gate region; other site 452652011818 putative PBP binding loops; other site 452652011819 ABC-ATPase subunit interface; other site 452652011820 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 452652011821 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 452652011822 Walker A/P-loop; other site 452652011823 ATP binding site [chemical binding]; other site 452652011824 Q-loop/lid; other site 452652011825 ABC transporter signature motif; other site 452652011826 Walker B; other site 452652011827 D-loop; other site 452652011828 H-loop/switch region; other site 452652011829 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 452652011830 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 452652011831 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 452652011832 Walker A/P-loop; other site 452652011833 ATP binding site [chemical binding]; other site 452652011834 Q-loop/lid; other site 452652011835 ABC transporter signature motif; other site 452652011836 Walker B; other site 452652011837 D-loop; other site 452652011838 H-loop/switch region; other site 452652011839 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 452652011840 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 452652011841 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 452652011842 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 452652011843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652011844 dimer interface [polypeptide binding]; other site 452652011845 conserved gate region; other site 452652011846 putative PBP binding loops; other site 452652011847 ABC-ATPase subunit interface; other site 452652011848 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 452652011849 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652011850 dimer interface [polypeptide binding]; other site 452652011851 conserved gate region; other site 452652011852 putative PBP binding loops; other site 452652011853 ABC-ATPase subunit interface; other site 452652011854 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 452652011855 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 452652011856 Walker A/P-loop; other site 452652011857 ATP binding site [chemical binding]; other site 452652011858 Q-loop/lid; other site 452652011859 ABC transporter signature motif; other site 452652011860 Walker B; other site 452652011861 D-loop; other site 452652011862 H-loop/switch region; other site 452652011863 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 452652011864 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 452652011865 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 452652011866 Walker A/P-loop; other site 452652011867 ATP binding site [chemical binding]; other site 452652011868 Q-loop/lid; other site 452652011869 ABC transporter signature motif; other site 452652011870 Walker B; other site 452652011871 D-loop; other site 452652011872 H-loop/switch region; other site 452652011873 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 452652011874 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 452652011875 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 452652011876 Walker A/P-loop; other site 452652011877 ATP binding site [chemical binding]; other site 452652011878 Q-loop/lid; other site 452652011879 ABC transporter signature motif; other site 452652011880 Walker B; other site 452652011881 D-loop; other site 452652011882 H-loop/switch region; other site 452652011883 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 452652011884 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 452652011885 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 452652011886 Walker A/P-loop; other site 452652011887 ATP binding site [chemical binding]; other site 452652011888 Q-loop/lid; other site 452652011889 ABC transporter signature motif; other site 452652011890 Walker B; other site 452652011891 D-loop; other site 452652011892 H-loop/switch region; other site 452652011893 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 452652011894 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 452652011895 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652011896 dimer interface [polypeptide binding]; other site 452652011897 conserved gate region; other site 452652011898 putative PBP binding loops; other site 452652011899 ABC-ATPase subunit interface; other site 452652011900 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 452652011901 peptide binding site [polypeptide binding]; other site 452652011902 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 452652011903 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 452652011904 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652011905 dimer interface [polypeptide binding]; other site 452652011906 conserved gate region; other site 452652011907 putative PBP binding loops; other site 452652011908 ABC-ATPase subunit interface; other site 452652011909 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 452652011910 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 452652011911 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 452652011912 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 452652011913 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 452652011914 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 452652011915 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 452652011916 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 452652011917 Walker A/P-loop; other site 452652011918 ATP binding site [chemical binding]; other site 452652011919 Q-loop/lid; other site 452652011920 ABC transporter signature motif; other site 452652011921 Walker B; other site 452652011922 D-loop; other site 452652011923 H-loop/switch region; other site 452652011924 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 452652011925 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 452652011926 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652011927 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652011928 intermolecular recognition site; other site 452652011929 active site 452652011930 dimerization interface [polypeptide binding]; other site 452652011931 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 452652011932 Ferredoxin [Energy production and conversion]; Region: COG1146 452652011933 4Fe-4S binding domain; Region: Fer4; pfam00037 452652011934 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 452652011935 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 452652011936 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652011937 homodimer interface [polypeptide binding]; other site 452652011938 catalytic residue [active] 452652011939 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 452652011940 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 452652011941 metal binding site [ion binding]; metal-binding site 452652011942 putative dimer interface [polypeptide binding]; other site 452652011943 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 452652011944 dihydropteroate synthase; Region: DHPS; TIGR01496 452652011945 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 452652011946 substrate binding pocket [chemical binding]; other site 452652011947 dimer interface [polypeptide binding]; other site 452652011948 inhibitor binding site; inhibition site 452652011949 DivIVA domain; Region: DivI1A_domain; TIGR03544 452652011950 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 452652011951 enoyl-CoA hydratase; Provisional; Region: PRK08140 452652011952 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 452652011953 substrate binding site [chemical binding]; other site 452652011954 oxyanion hole (OAH) forming residues; other site 452652011955 trimer interface [polypeptide binding]; other site 452652011956 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 452652011957 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 452652011958 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 452652011959 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652011960 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452652011961 DNA binding residues [nucleotide binding] 452652011962 Putative zinc-finger; Region: zf-HC2; pfam13490 452652011963 sec-independent translocase; Provisional; Region: PRK01371 452652011964 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 452652011965 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 452652011966 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 452652011967 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 452652011968 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 452652011969 MgtE intracellular N domain; Region: MgtE_N; smart00924 452652011970 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 452652011971 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 452652011972 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 452652011973 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 452652011974 oligomer interface [polypeptide binding]; other site 452652011975 metal binding site [ion binding]; metal-binding site 452652011976 metal binding site [ion binding]; metal-binding site 452652011977 putative Cl binding site [ion binding]; other site 452652011978 basic sphincter; other site 452652011979 hydrophobic gate; other site 452652011980 periplasmic entrance; other site 452652011981 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 452652011982 PemK-like protein; Region: PemK; pfam02452 452652011983 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 452652011984 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 452652011985 active site 452652011986 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 452652011987 TAP-like protein; Region: Abhydrolase_4; pfam08386 452652011988 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 452652011989 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 452652011990 ATP binding site [chemical binding]; other site 452652011991 putative Mg++ binding site [ion binding]; other site 452652011992 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 452652011993 nucleotide binding region [chemical binding]; other site 452652011994 ATP-binding site [chemical binding]; other site 452652011995 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 452652011996 dinuclear metal binding motif [ion binding]; other site 452652011997 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 452652011998 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652011999 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652012000 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 452652012001 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 452652012002 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 452652012003 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 452652012004 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652012005 NAD(P) binding site [chemical binding]; other site 452652012006 active site 452652012007 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 452652012008 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 452652012009 ATP binding site [chemical binding]; other site 452652012010 substrate interface [chemical binding]; other site 452652012011 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 452652012012 active site residue [active] 452652012013 Predicted integral membrane protein [Function unknown]; Region: COG0392 452652012014 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 452652012015 active site 452652012016 DNA binding site [nucleotide binding] 452652012017 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 452652012018 Part of AAA domain; Region: AAA_19; pfam13245 452652012019 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 452652012020 Family description; Region: UvrD_C_2; pfam13538 452652012021 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 452652012022 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 452652012023 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 452652012024 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 452652012025 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 452652012026 putative phosphate binding site [ion binding]; other site 452652012027 Predicted transcriptional regulators [Transcription]; Region: COG1695 452652012028 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 452652012029 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 452652012030 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 452652012031 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 452652012032 Walker A/P-loop; other site 452652012033 ATP binding site [chemical binding]; other site 452652012034 Q-loop/lid; other site 452652012035 ABC transporter signature motif; other site 452652012036 Walker B; other site 452652012037 D-loop; other site 452652012038 H-loop/switch region; other site 452652012039 hypothetical protein; Provisional; Region: PRK08201 452652012040 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 452652012041 metal binding site [ion binding]; metal-binding site 452652012042 putative dimer interface [polypeptide binding]; other site 452652012043 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 452652012044 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 452652012045 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 452652012046 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 452652012047 putative NADH binding site [chemical binding]; other site 452652012048 putative active site [active] 452652012049 nudix motif; other site 452652012050 putative metal binding site [ion binding]; other site 452652012051 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 452652012052 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 452652012053 DNA-binding site [nucleotide binding]; DNA binding site 452652012054 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 452652012055 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 452652012056 catalytic residues [active] 452652012057 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 452652012058 Part of AAA domain; Region: AAA_19; pfam13245 452652012059 Family description; Region: UvrD_C_2; pfam13538 452652012060 HRDC domain; Region: HRDC; pfam00570 452652012061 Transcription factor WhiB; Region: Whib; pfam02467 452652012062 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 452652012063 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 452652012064 ABC1 family; Region: ABC1; pfam03109 452652012065 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 452652012066 active site 452652012067 ATP binding site [chemical binding]; other site 452652012068 Protein of unknown function DUF45; Region: DUF45; pfam01863 452652012069 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 452652012070 nudix motif; other site 452652012071 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 452652012072 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 452652012073 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 452652012074 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 452652012075 putative NAD(P) binding site [chemical binding]; other site 452652012076 active site 452652012077 putative substrate binding site [chemical binding]; other site 452652012078 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 452652012079 MoaE homodimer interface [polypeptide binding]; other site 452652012080 MoaD interaction [polypeptide binding]; other site 452652012081 active site residues [active] 452652012082 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 452652012083 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 452652012084 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 452652012085 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 452652012086 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 452652012087 Glyco_18 domain; Region: Glyco_18; smart00636 452652012088 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 452652012089 active site 452652012090 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 452652012091 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452652012092 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452652012093 binding surface 452652012094 TPR motif; other site 452652012095 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 452652012096 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 452652012097 active site 452652012098 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 452652012099 Predicted GTPases [General function prediction only]; Region: COG1162 452652012100 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 452652012101 GTPase/Zn-binding domain interface [polypeptide binding]; other site 452652012102 GTP/Mg2+ binding site [chemical binding]; other site 452652012103 G4 box; other site 452652012104 G5 box; other site 452652012105 G1 box; other site 452652012106 Switch I region; other site 452652012107 G2 box; other site 452652012108 G3 box; other site 452652012109 Switch II region; other site 452652012110 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 452652012111 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 452652012112 hinge; other site 452652012113 active site 452652012114 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 452652012115 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 452652012116 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 452652012117 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 452652012118 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652012119 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452652012120 DNA binding residues [nucleotide binding] 452652012121 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 452652012122 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 452652012123 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 452652012124 Zn2+ binding site [ion binding]; other site 452652012125 Mg2+ binding site [ion binding]; other site 452652012126 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 452652012127 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452652012128 TPR motif; other site 452652012129 binding surface 452652012130 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 452652012131 active site 452652012132 catalytic residues [active] 452652012133 metal binding site [ion binding]; metal-binding site 452652012134 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 452652012135 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 452652012136 dimer interface [polypeptide binding]; other site 452652012137 putative radical transfer pathway; other site 452652012138 diiron center [ion binding]; other site 452652012139 tyrosyl radical; other site 452652012140 ribonucleoside-diphosphate reductase, alpha subunit; Region: NrdE_NrdA; TIGR02506 452652012141 Class I ribonucleotide reductase; Region: RNR_I; cd01679 452652012142 active site 452652012143 dimer interface [polypeptide binding]; other site 452652012144 catalytic residues [active] 452652012145 effector binding site; other site 452652012146 R2 peptide binding site; other site 452652012147 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 452652012148 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 452652012149 conserved cys residue [active] 452652012150 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452652012151 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452652012152 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 452652012153 catalytic core [active] 452652012154 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 452652012155 Na binding site [ion binding]; other site 452652012156 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 452652012157 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 452652012158 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 452652012159 DNA-binding site [nucleotide binding]; DNA binding site 452652012160 UTRA domain; Region: UTRA; pfam07702 452652012161 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 452652012162 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 452652012163 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 452652012164 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652012165 dimer interface [polypeptide binding]; other site 452652012166 conserved gate region; other site 452652012167 putative PBP binding loops; other site 452652012168 ABC-ATPase subunit interface; other site 452652012169 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652012170 dimer interface [polypeptide binding]; other site 452652012171 conserved gate region; other site 452652012172 putative PBP binding loops; other site 452652012173 ABC-ATPase subunit interface; other site 452652012174 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 452652012175 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 452652012176 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 452652012177 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 452652012178 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 452652012179 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 452652012180 dimer interface [polypeptide binding]; other site 452652012181 active site 452652012182 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 452652012183 dimer interface [polypeptide binding]; other site 452652012184 active site 452652012185 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 452652012186 PAS fold; Region: PAS_4; pfam08448 452652012187 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 452652012188 putative active site [active] 452652012189 heme pocket [chemical binding]; other site 452652012190 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 452652012191 Histidine kinase; Region: HisKA_2; pfam07568 452652012192 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652012193 ATP binding site [chemical binding]; other site 452652012194 Mg2+ binding site [ion binding]; other site 452652012195 G-X-G motif; other site 452652012196 Transcription factor WhiB; Region: Whib; pfam02467 452652012197 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 452652012198 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 452652012199 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 452652012200 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652012201 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 452652012202 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452652012203 DNA binding residues [nucleotide binding] 452652012204 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 452652012205 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 452652012206 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452652012207 Coenzyme A binding pocket [chemical binding]; other site 452652012208 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 452652012209 Predicted transcriptional regulators [Transcription]; Region: COG1725 452652012210 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 452652012211 DNA-binding site [nucleotide binding]; DNA binding site 452652012212 Nickel-containing superoxide dismutase; Region: Sod_Ni; pfam09055 452652012213 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 452652012214 Catalytic site [active] 452652012215 CGNR zinc finger; Region: zf-CGNR; pfam11706 452652012216 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 452652012217 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 452652012218 Walker A/P-loop; other site 452652012219 ATP binding site [chemical binding]; other site 452652012220 Q-loop/lid; other site 452652012221 ABC transporter signature motif; other site 452652012222 Walker B; other site 452652012223 D-loop; other site 452652012224 H-loop/switch region; other site 452652012225 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 452652012226 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652012227 dimer interface [polypeptide binding]; other site 452652012228 conserved gate region; other site 452652012229 putative PBP binding loops; other site 452652012230 ABC-ATPase subunit interface; other site 452652012231 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 452652012232 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 452652012233 substrate binding pocket [chemical binding]; other site 452652012234 membrane-bound complex binding site; other site 452652012235 hinge residues; other site 452652012236 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 452652012237 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 452652012238 substrate binding pocket [chemical binding]; other site 452652012239 membrane-bound complex binding site; other site 452652012240 hinge residues; other site 452652012241 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 452652012242 Malic enzyme, N-terminal domain; Region: malic; pfam00390 452652012243 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 452652012244 NAD(P) binding pocket [chemical binding]; other site 452652012245 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 452652012246 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 452652012247 NAD(P) binding site [chemical binding]; other site 452652012248 Predicted transcriptional regulators [Transcription]; Region: COG1695 452652012249 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 452652012250 putative DNA binding site [nucleotide binding]; other site 452652012251 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 452652012252 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 452652012253 Catalytic domain of Protein Kinases; Region: PKc; cd00180 452652012254 active site 452652012255 ATP binding site [chemical binding]; other site 452652012256 substrate binding site [chemical binding]; other site 452652012257 activation loop (A-loop); other site 452652012258 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 452652012259 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 452652012260 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 452652012261 TPP-binding site [chemical binding]; other site 452652012262 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 452652012263 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452652012264 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 452652012265 dimerization interface [polypeptide binding]; other site 452652012266 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452652012267 dimer interface [polypeptide binding]; other site 452652012268 phosphorylation site [posttranslational modification] 452652012269 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652012270 ATP binding site [chemical binding]; other site 452652012271 Mg2+ binding site [ion binding]; other site 452652012272 G-X-G motif; other site 452652012273 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 452652012274 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652012275 active site 452652012276 phosphorylation site [posttranslational modification] 452652012277 intermolecular recognition site; other site 452652012278 dimerization interface [polypeptide binding]; other site 452652012279 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 452652012280 DNA binding site [nucleotide binding] 452652012281 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 452652012282 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452652012283 Walker A motif; other site 452652012284 ATP binding site [chemical binding]; other site 452652012285 Walker B motif; other site 452652012286 arginine finger; other site 452652012287 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 452652012288 Predicted membrane protein [Function unknown]; Region: COG2246 452652012289 GtrA-like protein; Region: GtrA; pfam04138 452652012290 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 452652012291 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 452652012292 MarR family; Region: MarR_2; pfam12802 452652012293 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 452652012294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652012295 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 452652012296 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 452652012297 NlpC/P60 family; Region: NLPC_P60; pfam00877 452652012298 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 452652012299 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 452652012300 putative molybdopterin cofactor binding site [chemical binding]; other site 452652012301 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 452652012302 putative molybdopterin cofactor binding site; other site 452652012303 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 452652012304 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652012305 dimer interface [polypeptide binding]; other site 452652012306 conserved gate region; other site 452652012307 putative PBP binding loops; other site 452652012308 ABC-ATPase subunit interface; other site 452652012309 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 452652012310 active site 452652012311 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 452652012312 dimer interface [polypeptide binding]; other site 452652012313 non-prolyl cis peptide bond; other site 452652012314 insertion regions; other site 452652012315 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452652012316 Coenzyme A binding pocket [chemical binding]; other site 452652012317 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 452652012318 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 452652012319 substrate binding pocket [chemical binding]; other site 452652012320 membrane-bound complex binding site; other site 452652012321 hinge residues; other site 452652012322 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 452652012323 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652012324 dimer interface [polypeptide binding]; other site 452652012325 conserved gate region; other site 452652012326 putative PBP binding loops; other site 452652012327 ABC-ATPase subunit interface; other site 452652012328 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 452652012329 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 452652012330 Walker A/P-loop; other site 452652012331 ATP binding site [chemical binding]; other site 452652012332 Q-loop/lid; other site 452652012333 ABC transporter signature motif; other site 452652012334 Walker B; other site 452652012335 D-loop; other site 452652012336 H-loop/switch region; other site 452652012337 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 452652012338 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 452652012339 substrate binding pocket [chemical binding]; other site 452652012340 membrane-bound complex binding site; other site 452652012341 hinge residues; other site 452652012342 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 452652012343 FeS/SAM binding site; other site 452652012344 coproporphyrinogen III oxidase; Validated; Region: PRK08208 452652012345 HemN C-terminal domain; Region: HemN_C; pfam06969 452652012346 Sulfatase; Region: Sulfatase; cl17466 452652012347 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 452652012348 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 452652012349 Substrate binding site [chemical binding]; other site 452652012350 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 452652012351 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 452652012352 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652012353 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652012354 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 452652012355 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 452652012356 Response regulator receiver domain; Region: Response_reg; pfam00072 452652012357 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652012358 active site 452652012359 phosphorylation site [posttranslational modification] 452652012360 intermolecular recognition site; other site 452652012361 dimerization interface [polypeptide binding]; other site 452652012362 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 452652012363 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 452652012364 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 452652012365 active site 452652012366 HIGH motif; other site 452652012367 KMSK motif region; other site 452652012368 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 452652012369 tRNA binding surface [nucleotide binding]; other site 452652012370 anticodon binding site; other site 452652012371 diaminopimelate decarboxylase; Region: lysA; TIGR01048 452652012372 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 452652012373 active site 452652012374 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 452652012375 substrate binding site [chemical binding]; other site 452652012376 catalytic residues [active] 452652012377 dimer interface [polypeptide binding]; other site 452652012378 homoserine dehydrogenase; Provisional; Region: PRK06349 452652012379 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 452652012380 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 452652012381 threonine synthase; Reviewed; Region: PRK06721 452652012382 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 452652012383 homodimer interface [polypeptide binding]; other site 452652012384 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652012385 catalytic residue [active] 452652012386 homoserine kinase; Provisional; Region: PRK01212 452652012387 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 452652012388 transcription termination factor Rho; Provisional; Region: PRK12608 452652012389 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 452652012390 RNA binding site [nucleotide binding]; other site 452652012391 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 452652012392 multimer interface [polypeptide binding]; other site 452652012393 Walker A motif; other site 452652012394 ATP binding site [chemical binding]; other site 452652012395 Walker B motif; other site 452652012396 cell envelope-related function transcriptional attenuator common domain; Region: lytR_cpsA_psr; TIGR00350 452652012397 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 452652012398 peptide chain release factor 1; Validated; Region: prfA; PRK00591 452652012399 This domain is found in peptide chain release factors; Region: PCRF; smart00937 452652012400 RF-1 domain; Region: RF-1; pfam00472 452652012401 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 452652012402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652012403 S-adenosylmethionine binding site [chemical binding]; other site 452652012404 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 452652012405 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 452652012406 Low molecular weight phosphatase family; Region: LMWPc; cl00105 452652012407 active site 452652012408 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 452652012409 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 452652012410 catalytic residue [active] 452652012411 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 452652012412 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 452652012413 Mg++ binding site [ion binding]; other site 452652012414 putative catalytic motif [active] 452652012415 substrate binding site [chemical binding]; other site 452652012416 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 452652012417 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 452652012418 ATP synthase subunit C; Region: ATP-synt_C; cl00466 452652012419 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 452652012420 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 452652012421 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 452652012422 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 452652012423 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 452652012424 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 452652012425 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 452652012426 beta subunit interaction interface [polypeptide binding]; other site 452652012427 Walker A motif; other site 452652012428 ATP binding site [chemical binding]; other site 452652012429 Walker B motif; other site 452652012430 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 452652012431 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 452652012432 core domain interface [polypeptide binding]; other site 452652012433 delta subunit interface [polypeptide binding]; other site 452652012434 epsilon subunit interface [polypeptide binding]; other site 452652012435 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 452652012436 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 452652012437 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 452652012438 alpha subunit interaction interface [polypeptide binding]; other site 452652012439 Walker A motif; other site 452652012440 ATP binding site [chemical binding]; other site 452652012441 Walker B motif; other site 452652012442 inhibitor binding site; inhibition site 452652012443 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 452652012444 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 452652012445 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 452652012446 gamma subunit interface [polypeptide binding]; other site 452652012447 epsilon subunit interface [polypeptide binding]; other site 452652012448 LBP interface [polypeptide binding]; other site 452652012449 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 452652012450 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 452652012451 Histidine kinase; Region: HisKA_3; pfam07730 452652012452 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 452652012453 ATP binding site [chemical binding]; other site 452652012454 Mg2+ binding site [ion binding]; other site 452652012455 G-X-G motif; other site 452652012456 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652012457 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652012458 phosphorylation site [posttranslational modification] 452652012459 intermolecular recognition site; other site 452652012460 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652012461 DNA binding residues [nucleotide binding] 452652012462 dimerization interface [polypeptide binding]; other site 452652012463 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 452652012464 anti sigma factor interaction site; other site 452652012465 regulatory phosphorylation site [posttranslational modification]; other site 452652012466 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 452652012467 hypothetical protein; Provisional; Region: PRK03298 452652012468 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 452652012469 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 452652012470 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 452652012471 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 452652012472 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 452652012473 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652012474 Walker A/P-loop; other site 452652012475 ATP binding site [chemical binding]; other site 452652012476 Q-loop/lid; other site 452652012477 ABC transporter signature motif; other site 452652012478 Walker B; other site 452652012479 D-loop; other site 452652012480 H-loop/switch region; other site 452652012481 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 452652012482 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 452652012483 F0F1 ATP synthase subunit B; Validated; Region: PRK07352 452652012484 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 452652012485 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 452652012486 dimer interface [polypeptide binding]; other site 452652012487 substrate binding site [chemical binding]; other site 452652012488 metal binding site [ion binding]; metal-binding site 452652012489 putative acyltransferase; Provisional; Region: PRK05790 452652012490 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 452652012491 dimer interface [polypeptide binding]; other site 452652012492 active site 452652012493 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 452652012494 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 452652012495 Walker A; other site 452652012496 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 452652012497 G4 box; other site 452652012498 G5 box; other site 452652012499 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 452652012500 MarR family; Region: MarR_2; pfam12802 452652012501 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 452652012502 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 452652012503 ATP binding site [chemical binding]; other site 452652012504 Mg2+ binding site [ion binding]; other site 452652012505 G-X-G motif; other site 452652012506 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 452652012507 Protein of unknown function (DUF742); Region: DUF742; pfam05331 452652012508 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 452652012509 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 452652012510 G1 box; other site 452652012511 GTP/Mg2+ binding site [chemical binding]; other site 452652012512 G2 box; other site 452652012513 Switch I region; other site 452652012514 G3 box; other site 452652012515 Switch II region; other site 452652012516 G4 box; other site 452652012517 G5 box; other site 452652012518 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 452652012519 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 452652012520 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 452652012521 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 452652012522 Predicted membrane protein (DUF2127); Region: DUF2127; cl01785 452652012523 integral membrane protein; Region: integ_memb_HG; TIGR03954 452652012524 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 452652012525 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 452652012526 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 452652012527 active site 452652012528 Zn binding site [ion binding]; other site 452652012529 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 452652012530 MarR family; Region: MarR; pfam01047 452652012531 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 452652012532 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 452652012533 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 452652012534 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652012535 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 452652012536 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652012537 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652012538 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 452652012539 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 452652012540 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 452652012541 pyruvate kinase; Provisional; Region: PRK06247 452652012542 domain interfaces; other site 452652012543 active site 452652012544 propionate/acetate kinase; Provisional; Region: PRK12379 452652012545 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 452652012546 phosphate acetyltransferase; Reviewed; Region: PRK05632 452652012547 DRTGG domain; Region: DRTGG; pfam07085 452652012548 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 452652012549 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 452652012550 glycogen branching enzyme; Provisional; Region: PRK05402 452652012551 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 452652012552 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 452652012553 active site 452652012554 catalytic site [active] 452652012555 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 452652012556 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 452652012557 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 452652012558 trehalose synthase; Region: treS_nterm; TIGR02456 452652012559 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 452652012560 active site 452652012561 catalytic site [active] 452652012562 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 452652012563 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 452652012564 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 452652012565 active site 452652012566 homodimer interface [polypeptide binding]; other site 452652012567 catalytic site [active] 452652012568 acceptor binding site [chemical binding]; other site 452652012569 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 452652012570 putative homodimer interface [polypeptide binding]; other site 452652012571 putative active site pocket [active] 452652012572 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 452652012573 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 452652012574 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 452652012575 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652012576 Walker A/P-loop; other site 452652012577 ATP binding site [chemical binding]; other site 452652012578 Q-loop/lid; other site 452652012579 ABC transporter signature motif; other site 452652012580 Walker B; other site 452652012581 D-loop; other site 452652012582 H-loop/switch region; other site 452652012583 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 452652012584 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 452652012585 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652012586 Q-loop/lid; other site 452652012587 ABC transporter signature motif; other site 452652012588 Walker B; other site 452652012589 D-loop; other site 452652012590 H-loop/switch region; other site 452652012591 Uncharacterized glycoside hydrolase family 99-like domain; Region: GH99_GH71_like_2; cd11576 452652012592 putative ligand binding site [chemical binding]; other site 452652012593 putative catalytic site [active] 452652012594 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 452652012595 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 452652012596 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 452652012597 sugar binding site [chemical binding]; other site 452652012598 Amidase; Region: Amidase; cl11426 452652012599 Amidase; Region: Amidase; cl11426 452652012600 urea carboxylase; Region: urea_carbox; TIGR02712 452652012601 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 452652012602 ATP-grasp domain; Region: ATP-grasp_4; cl17255 452652012603 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 452652012604 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 452652012605 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 452652012606 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 452652012607 carboxyltransferase (CT) interaction site; other site 452652012608 biotinylation site [posttranslational modification]; other site 452652012609 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 452652012610 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 452652012611 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 452652012612 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 452652012613 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 452652012614 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 452652012615 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 452652012616 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652012617 Walker A/P-loop; other site 452652012618 ATP binding site [chemical binding]; other site 452652012619 Q-loop/lid; other site 452652012620 ABC transporter signature motif; other site 452652012621 Walker B; other site 452652012622 D-loop; other site 452652012623 H-loop/switch region; other site 452652012624 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 452652012625 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 452652012626 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652012627 Walker A/P-loop; other site 452652012628 ATP binding site [chemical binding]; other site 452652012629 Q-loop/lid; other site 452652012630 ABC transporter signature motif; other site 452652012631 Walker B; other site 452652012632 D-loop; other site 452652012633 H-loop/switch region; other site 452652012634 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 452652012635 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 452652012636 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 452652012637 active site 452652012638 catalytic site [active] 452652012639 Bacterial Ig-like domain; Region: Big_5; pfam13205 452652012640 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 452652012641 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 452652012642 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 452652012643 Bacterial Ig-like domain; Region: Big_5; pfam13205 452652012644 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 452652012645 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 452652012646 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 452652012647 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 452652012648 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 452652012649 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 452652012650 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 452652012651 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 452652012652 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 452652012653 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 452652012654 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 452652012655 dimer interface [polypeptide binding]; other site 452652012656 active site 452652012657 glycine-pyridoxal phosphate binding site [chemical binding]; other site 452652012658 folate binding site [chemical binding]; other site 452652012659 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 452652012660 lipoyl attachment site [posttranslational modification]; other site 452652012661 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 452652012662 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 452652012663 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 452652012664 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652012665 dimer interface [polypeptide binding]; other site 452652012666 conserved gate region; other site 452652012667 putative PBP binding loops; other site 452652012668 ABC-ATPase subunit interface; other site 452652012669 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 452652012670 peptide binding site [polypeptide binding]; other site 452652012671 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 452652012672 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 452652012673 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652012674 dimer interface [polypeptide binding]; other site 452652012675 conserved gate region; other site 452652012676 putative PBP binding loops; other site 452652012677 ABC-ATPase subunit interface; other site 452652012678 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 452652012679 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 452652012680 Walker A/P-loop; other site 452652012681 ATP binding site [chemical binding]; other site 452652012682 Q-loop/lid; other site 452652012683 ABC transporter signature motif; other site 452652012684 Walker B; other site 452652012685 D-loop; other site 452652012686 H-loop/switch region; other site 452652012687 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 452652012688 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 452652012689 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 452652012690 Walker A/P-loop; other site 452652012691 ATP binding site [chemical binding]; other site 452652012692 Q-loop/lid; other site 452652012693 ABC transporter signature motif; other site 452652012694 Walker B; other site 452652012695 D-loop; other site 452652012696 H-loop/switch region; other site 452652012697 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 452652012698 Predicted membrane protein [Function unknown]; Region: COG2860 452652012699 UPF0126 domain; Region: UPF0126; pfam03458 452652012700 UPF0126 domain; Region: UPF0126; pfam03458 452652012701 Transcriptional regulator [Transcription]; Region: IclR; COG1414 452652012702 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 452652012703 Bacterial transcriptional regulator; Region: IclR; pfam01614 452652012704 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 452652012705 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 452652012706 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 452652012707 catalytic residue [active] 452652012708 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 452652012709 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 452652012710 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652012711 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 452652012712 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 452652012713 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 452652012714 short chain dehydrogenase; Provisional; Region: PRK08219 452652012715 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652012716 NAD(P) binding site [chemical binding]; other site 452652012717 active site 452652012718 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 452652012719 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 452652012720 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 452652012721 nucleotide binding pocket [chemical binding]; other site 452652012722 K-X-D-G motif; other site 452652012723 catalytic site [active] 452652012724 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 452652012725 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 452652012726 Helix-hairpin-helix motif; Region: HHH; pfam00633 452652012727 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 452652012728 Dimer interface [polypeptide binding]; other site 452652012729 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 452652012730 metal binding site [ion binding]; metal-binding site 452652012731 active site 452652012732 I-site; other site 452652012733 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 452652012734 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 452652012735 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 452652012736 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 452652012737 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 452652012738 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 452652012739 GatB domain; Region: GatB_Yqey; smart00845 452652012740 AAA ATPase domain; Region: AAA_16; pfam13191 452652012741 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452652012742 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652012743 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652012744 DNA binding residues [nucleotide binding] 452652012745 dimerization interface [polypeptide binding]; other site 452652012746 PAS domain S-box; Region: sensory_box; TIGR00229 452652012747 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452652012748 putative active site [active] 452652012749 heme pocket [chemical binding]; other site 452652012750 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 452652012751 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 452652012752 metal binding site [ion binding]; metal-binding site 452652012753 active site 452652012754 I-site; other site 452652012755 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 452652012756 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 452652012757 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 452652012758 PYR/PP interface [polypeptide binding]; other site 452652012759 dimer interface [polypeptide binding]; other site 452652012760 TPP binding site [chemical binding]; other site 452652012761 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 452652012762 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 452652012763 TPP-binding site [chemical binding]; other site 452652012764 dimer interface [polypeptide binding]; other site 452652012765 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 452652012766 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 452652012767 putative valine binding site [chemical binding]; other site 452652012768 dimer interface [polypeptide binding]; other site 452652012769 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 452652012770 ketol-acid reductoisomerase; Provisional; Region: PRK05479 452652012771 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 452652012772 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 452652012773 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 452652012774 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 452652012775 ligand binding site [chemical binding]; other site 452652012776 NAD binding site [chemical binding]; other site 452652012777 dimerization interface [polypeptide binding]; other site 452652012778 catalytic site [active] 452652012779 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 452652012780 putative L-serine binding site [chemical binding]; other site 452652012781 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 452652012782 putative active site [active] 452652012783 catalytic triad [active] 452652012784 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 452652012785 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 452652012786 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 452652012787 putative active site [active] 452652012788 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 452652012789 tartrate dehydrogenase; Region: TTC; TIGR02089 452652012790 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 452652012791 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 452652012792 homodimer interface [polypeptide binding]; other site 452652012793 substrate-cofactor binding pocket; other site 452652012794 catalytic residue [active] 452652012795 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 452652012796 putative active site [active] 452652012797 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 452652012798 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 452652012799 active site 452652012800 catalytic residues [active] 452652012801 metal binding site [ion binding]; metal-binding site 452652012802 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 452652012803 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 452652012804 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 452652012805 G1 box; other site 452652012806 GTP/Mg2+ binding site [chemical binding]; other site 452652012807 G2 box; other site 452652012808 Switch I region; other site 452652012809 G3 box; other site 452652012810 Switch II region; other site 452652012811 G4 box; other site 452652012812 G5 box; other site 452652012813 Protein of unknown function (DUF742); Region: DUF742; pfam05331 452652012814 Roadblock/LC7 domain; Region: Robl_LC7; pfam03259 452652012815 Nitrate and nitrite sensing; Region: NIT; pfam08376 452652012816 HAMP domain; Region: HAMP; pfam00672 452652012817 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452652012818 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652012819 ATP binding site [chemical binding]; other site 452652012820 Mg2+ binding site [ion binding]; other site 452652012821 G-X-G motif; other site 452652012822 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 452652012823 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 452652012824 G1 box; other site 452652012825 GTP/Mg2+ binding site [chemical binding]; other site 452652012826 G2 box; other site 452652012827 Switch I region; other site 452652012828 G3 box; other site 452652012829 Switch II region; other site 452652012830 G4 box; other site 452652012831 G5 box; other site 452652012832 Protein of unknown function (DUF742); Region: DUF742; pfam05331 452652012833 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 452652012834 Nitrate and nitrite sensing; Region: NIT; pfam08376 452652012835 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452652012836 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652012837 ATP binding site [chemical binding]; other site 452652012838 Mg2+ binding site [ion binding]; other site 452652012839 G-X-G motif; other site 452652012840 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 452652012841 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 452652012842 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 452652012843 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 452652012844 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 452652012845 active site 452652012846 HIGH motif; other site 452652012847 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 452652012848 active site 452652012849 KMSKS motif; other site 452652012850 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 452652012851 Transcriptional regulator [Transcription]; Region: IclR; COG1414 452652012852 Bacterial transcriptional regulator; Region: IclR; pfam01614 452652012853 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 452652012854 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 452652012855 substrate binding site [chemical binding]; other site 452652012856 ligand binding site [chemical binding]; other site 452652012857 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 452652012858 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 452652012859 substrate binding site [chemical binding]; other site 452652012860 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 452652012861 IHF dimer interface [polypeptide binding]; other site 452652012862 IHF - DNA interface [nucleotide binding]; other site 452652012863 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 452652012864 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 452652012865 DNA-binding site [nucleotide binding]; DNA binding site 452652012866 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 452652012867 Guanylyl transferase CofC like; Region: CofC; cl17472 452652012868 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 452652012869 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 452652012870 putative acyl-acceptor binding pocket; other site 452652012871 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 452652012872 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 452652012873 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 452652012874 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 452652012875 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 452652012876 ATP-grasp domain; Region: ATP-grasp_4; cl17255 452652012877 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 452652012878 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 452652012879 AsnC family; Region: AsnC_trans_reg; pfam01037 452652012880 thiamine monophosphate kinase; Provisional; Region: PRK05731 452652012881 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 452652012882 ATP binding site [chemical binding]; other site 452652012883 dimerization interface [polypeptide binding]; other site 452652012884 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 452652012885 phosphofructokinase; Region: PFK_mixed; TIGR02483 452652012886 active site 452652012887 ADP/pyrophosphate binding site [chemical binding]; other site 452652012888 dimerization interface [polypeptide binding]; other site 452652012889 allosteric effector site; other site 452652012890 fructose-1,6-bisphosphate binding site; other site 452652012891 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 452652012892 dimer interface [polypeptide binding]; other site 452652012893 substrate binding site [chemical binding]; other site 452652012894 ATP binding site [chemical binding]; other site 452652012895 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 452652012896 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 452652012897 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 452652012898 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 452652012899 generic binding surface II; other site 452652012900 ssDNA binding site; other site 452652012901 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 452652012902 ATP binding site [chemical binding]; other site 452652012903 putative Mg++ binding site [ion binding]; other site 452652012904 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 452652012905 nucleotide binding region [chemical binding]; other site 452652012906 ATP-binding site [chemical binding]; other site 452652012907 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652012908 S-adenosylmethionine binding site [chemical binding]; other site 452652012909 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 452652012910 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 452652012911 active site 452652012912 (T/H)XGH motif; other site 452652012913 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 452652012914 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 452652012915 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 452652012916 ribonuclease III; Reviewed; Region: rnc; PRK00102 452652012917 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 452652012918 dimerization interface [polypeptide binding]; other site 452652012919 active site 452652012920 metal binding site [ion binding]; metal-binding site 452652012921 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 452652012922 dsRNA binding site [nucleotide binding]; other site 452652012923 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 452652012924 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 452652012925 DNA binding site [nucleotide binding] 452652012926 catalytic residue [active] 452652012927 H2TH interface [polypeptide binding]; other site 452652012928 putative catalytic residues [active] 452652012929 turnover-facilitating residue; other site 452652012930 intercalation triad [nucleotide binding]; other site 452652012931 8OG recognition residue [nucleotide binding]; other site 452652012932 putative reading head residues; other site 452652012933 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 452652012934 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 452652012935 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 452652012936 acylphosphatase; Provisional; Region: PRK14422 452652012937 Protein of unknown function (DUF972); Region: DUF972; pfam06156 452652012938 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 452652012939 AAA domain; Region: AAA_23; pfam13476 452652012940 Walker A/P-loop; other site 452652012941 ATP binding site [chemical binding]; other site 452652012942 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 452652012943 ABC transporter signature motif; other site 452652012944 Walker B; other site 452652012945 D-loop; other site 452652012946 H-loop/switch region; other site 452652012947 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 452652012948 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 452652012949 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 452652012950 Bifunctional DNA primase/polymerase, N-terminal; Region: Prim-Pol; smart00943 452652012951 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452652012952 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 452652012953 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 452652012954 Nitrogen regulatory protein P-II; Region: P-II; smart00938 452652012955 PII uridylyl-transferase; Provisional; Region: PRK03381 452652012956 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 452652012957 metal binding triad; other site 452652012958 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 452652012959 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 452652012960 signal recognition particle protein; Provisional; Region: PRK10867 452652012961 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 452652012962 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 452652012963 P loop; other site 452652012964 GTP binding site [chemical binding]; other site 452652012965 Signal peptide binding domain; Region: SRP_SPB; pfam02978 452652012966 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 452652012967 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 452652012968 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 452652012969 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452652012970 Walker A motif; other site 452652012971 ATP binding site [chemical binding]; other site 452652012972 Walker B motif; other site 452652012973 arginine finger; other site 452652012974 Peptidase family M41; Region: Peptidase_M41; pfam01434 452652012975 prolyl-tRNA synthetase; Provisional; Region: PRK08661 452652012976 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 452652012977 dimer interface [polypeptide binding]; other site 452652012978 motif 1; other site 452652012979 active site 452652012980 motif 2; other site 452652012981 motif 3; other site 452652012982 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 452652012983 anticodon binding site; other site 452652012984 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 452652012985 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 452652012986 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 452652012987 RimM N-terminal domain; Region: RimM; pfam01782 452652012988 PRC-barrel domain; Region: PRC; pfam05239 452652012989 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 452652012990 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 452652012991 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 452652012992 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 452652012993 Catalytic site [active] 452652012994 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 452652012995 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 452652012996 Catalytic site [active] 452652012997 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 452652012998 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 452652012999 Catalytic site [active] 452652013000 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 452652013001 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 452652013002 Catalytic site [active] 452652013003 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 452652013004 nudix motif; other site 452652013005 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 452652013006 hypothetical protein; Reviewed; Region: PRK12497 452652013007 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 452652013008 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 452652013009 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 452652013010 salt bridge; other site 452652013011 non-specific DNA binding site [nucleotide binding]; other site 452652013012 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 452652013013 sequence-specific DNA binding site [nucleotide binding]; other site 452652013014 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 452652013015 ThiF family; Region: ThiF; pfam00899 452652013016 ATP binding site [chemical binding]; other site 452652013017 Winged helix-turn helix; Region: HTH_29; pfam13551 452652013018 Helix-turn-helix domain; Region: HTH_28; pfam13518 452652013019 Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately...; Region: REM; cl02520 452652013020 RES domain; Region: RES; pfam08808 452652013021 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 452652013022 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 452652013023 catalytic residues [active] 452652013024 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 452652013025 Domain of unknown function (DUF932); Region: DUF932; cl12129 452652013026 Replication-relaxation; Region: Replic_Relax; pfam13814 452652013027 AAA-like domain; Region: AAA_10; pfam12846 452652013028 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 452652013029 nudix motif; other site 452652013030 RibD C-terminal domain; Region: RibD_C; cl17279 452652013031 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 452652013032 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 452652013033 RibD C-terminal domain; Region: RibD_C; cl17279 452652013034 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652013035 sequence-specific DNA binding site [nucleotide binding]; other site 452652013036 salt bridge; other site 452652013037 Cupin superfamily protein; Region: Cupin_4; pfam08007 452652013038 Cupin-like domain; Region: Cupin_8; pfam13621 452652013039 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 452652013040 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 452652013041 active site 452652013042 catalytic tetrad [active] 452652013043 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 452652013044 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 452652013045 Lsr2; Region: Lsr2; pfam11774 452652013046 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 452652013047 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 452652013048 HSP70 interaction site [polypeptide binding]; other site 452652013049 Replication-relaxation; Region: Replic_Relax; pfam13814 452652013050 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452652013051 AAA-like domain; Region: AAA_10; pfam12846 452652013052 Adenovirus IVa2 protein; Region: Adeno_IVa2; pfam02456 452652013053 Walker A motif; other site 452652013054 ATP binding site [chemical binding]; other site 452652013055 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 452652013056 Domain of unknown function (DUF3825); Region: DUF3825; pfam12873 452652013057 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 452652013058 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 452652013059 catalytic residues [active] 452652013060 catalytic nucleophile [active] 452652013061 Recombinase; Region: Recombinase; pfam07508 452652013062 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 452652013063 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 452652013064 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 452652013065 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 452652013066 DNA protecting protein DprA; Region: dprA; TIGR00732 452652013067 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 452652013068 RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288 452652013069 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652013070 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 452652013071 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452652013072 DNA binding residues [nucleotide binding] 452652013073 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 452652013074 rRNA interaction site [nucleotide binding]; other site 452652013075 S8 interaction site; other site 452652013076 putative laminin-1 binding site; other site 452652013077 elongation factor Ts; Provisional; Region: tsf; PRK09377 452652013078 UBA/TS-N domain; Region: UBA; pfam00627 452652013079 Elongation factor TS; Region: EF_TS; pfam00889 452652013080 Elongation factor TS; Region: EF_TS; pfam00889 452652013081 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 452652013082 putative nucleotide binding site [chemical binding]; other site 452652013083 uridine monophosphate binding site [chemical binding]; other site 452652013084 homohexameric interface [polypeptide binding]; other site 452652013085 ribosome recycling factor; Reviewed; Region: frr; PRK00083 452652013086 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 452652013087 hinge region; other site 452652013088 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 452652013089 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 452652013090 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 452652013091 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 452652013092 FeS/SAM binding site; other site 452652013093 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 452652013094 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 452652013095 Walker A/P-loop; other site 452652013096 ATP binding site [chemical binding]; other site 452652013097 Q-loop/lid; other site 452652013098 ABC transporter signature motif; other site 452652013099 Walker B; other site 452652013100 D-loop; other site 452652013101 H-loop/switch region; other site 452652013102 hypothetical protein; Provisional; Region: PRK06541 452652013103 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 452652013104 inhibitor-cofactor binding pocket; inhibition site 452652013105 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652013106 catalytic residue [active] 452652013107 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 452652013108 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 452652013109 AsnC family; Region: AsnC_trans_reg; pfam01037 452652013110 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 452652013111 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 452652013112 tetrameric interface [polypeptide binding]; other site 452652013113 NAD binding site [chemical binding]; other site 452652013114 catalytic residues [active] 452652013115 substrate binding site [chemical binding]; other site 452652013116 hypothetical protein; Provisional; Region: PRK06062 452652013117 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 452652013118 inhibitor-cofactor binding pocket; inhibition site 452652013119 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652013120 catalytic residue [active] 452652013121 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 452652013122 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 452652013123 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 452652013124 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 452652013125 tetrameric interface [polypeptide binding]; other site 452652013126 NAD binding site [chemical binding]; other site 452652013127 catalytic residues [active] 452652013128 substrate binding site [chemical binding]; other site 452652013129 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 452652013130 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 452652013131 tetrameric interface [polypeptide binding]; other site 452652013132 NAD binding site [chemical binding]; other site 452652013133 catalytic residues [active] 452652013134 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652013135 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652013136 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 452652013137 Histidine kinase; Region: HisKA_3; pfam07730 452652013138 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652013139 ATP binding site [chemical binding]; other site 452652013140 Mg2+ binding site [ion binding]; other site 452652013141 G-X-G motif; other site 452652013142 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652013143 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652013144 active site 452652013145 phosphorylation site [posttranslational modification] 452652013146 intermolecular recognition site; other site 452652013147 dimerization interface [polypeptide binding]; other site 452652013148 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652013149 dimerization interface [polypeptide binding]; other site 452652013150 DNA binding residues [nucleotide binding] 452652013151 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 452652013152 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 452652013153 Uncharacterized conserved protein [Function unknown]; Region: COG1739 452652013154 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 452652013155 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 452652013156 Restriction endonuclease; Region: Mrr_cat; pfam04471 452652013157 Transcriptional regulator [Transcription]; Region: LysR; COG0583 452652013158 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 452652013159 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 452652013160 putative dimerization interface [polypeptide binding]; other site 452652013161 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 452652013162 EamA-like transporter family; Region: EamA; pfam00892 452652013163 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 452652013164 MarR family; Region: MarR; pfam01047 452652013165 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424 452652013166 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 452652013167 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 452652013168 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 452652013169 inhibitor-cofactor binding pocket; inhibition site 452652013170 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652013171 catalytic residue [active] 452652013172 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 452652013173 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 452652013174 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 452652013175 Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147 452652013176 NAD(P) binding site [chemical binding]; other site 452652013177 catalytic residues [active] 452652013178 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 452652013179 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 452652013180 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 452652013181 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 452652013182 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 452652013183 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 452652013184 active site 452652013185 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 452652013186 protein binding site [polypeptide binding]; other site 452652013187 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 452652013188 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 452652013189 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 452652013190 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 452652013191 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 452652013192 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 452652013193 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 452652013194 Coenzyme A binding pocket [chemical binding]; other site 452652013195 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 452652013196 ribosome maturation protein RimP; Reviewed; Region: PRK00092 452652013197 Sm and related proteins; Region: Sm_like; cl00259 452652013198 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 452652013199 putative oligomer interface [polypeptide binding]; other site 452652013200 putative RNA binding site [nucleotide binding]; other site 452652013201 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 452652013202 NusA N-terminal domain; Region: NusA_N; pfam08529 452652013203 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 452652013204 RNA binding site [nucleotide binding]; other site 452652013205 homodimer interface [polypeptide binding]; other site 452652013206 NusA-like KH domain; Region: KH_5; pfam13184 452652013207 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 452652013208 G-X-X-G motif; other site 452652013209 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 452652013210 putative RNA binding cleft [nucleotide binding]; other site 452652013211 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 452652013212 translation initiation factor IF-2; Region: IF-2; TIGR00487 452652013213 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 452652013214 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 452652013215 G1 box; other site 452652013216 putative GEF interaction site [polypeptide binding]; other site 452652013217 GTP/Mg2+ binding site [chemical binding]; other site 452652013218 Switch I region; other site 452652013219 G2 box; other site 452652013220 G3 box; other site 452652013221 Switch II region; other site 452652013222 G4 box; other site 452652013223 G5 box; other site 452652013224 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 452652013225 Translation-initiation factor 2; Region: IF-2; pfam11987 452652013226 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 452652013227 Protein of unknown function (DUF503); Region: DUF503; pfam04456 452652013228 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 452652013229 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 452652013230 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 452652013231 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 452652013232 RNA binding site [nucleotide binding]; other site 452652013233 active site 452652013234 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 452652013235 WHG domain; Region: WHG; pfam13305 452652013236 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 452652013237 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652013238 NAD(P) binding site [chemical binding]; other site 452652013239 active site 452652013240 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 452652013241 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 452652013242 active site 452652013243 Riboflavin kinase; Region: Flavokinase; pfam01687 452652013244 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 452652013245 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 452652013246 Protein of unknown function (DUF690); Region: DUF690; cl04939 452652013247 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 452652013248 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 452652013249 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 452652013250 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 452652013251 active site 452652013252 catalytic residues [active] 452652013253 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 452652013254 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 452652013255 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 452652013256 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 452652013257 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 452652013258 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 452652013259 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 452652013260 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 452652013261 16S/18S rRNA binding site [nucleotide binding]; other site 452652013262 S13e-L30e interaction site [polypeptide binding]; other site 452652013263 25S rRNA binding site [nucleotide binding]; other site 452652013264 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 452652013265 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 452652013266 oligomer interface [polypeptide binding]; other site 452652013267 RNA binding site [nucleotide binding]; other site 452652013268 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 452652013269 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 452652013270 RNase E interface [polypeptide binding]; other site 452652013271 trimer interface [polypeptide binding]; other site 452652013272 active site 452652013273 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 452652013274 putative nucleic acid binding region [nucleotide binding]; other site 452652013275 G-X-X-G motif; other site 452652013276 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 452652013277 RNA binding site [nucleotide binding]; other site 452652013278 domain interface; other site 452652013279 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 452652013280 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 452652013281 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 452652013282 dihydrodipicolinate reductase; Provisional; Region: PRK00048 452652013283 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 452652013284 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 452652013285 Thymidylate synthase complementing protein; Region: Thy1; pfam02511 452652013286 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 452652013287 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 452652013288 dimer interface [polypeptide binding]; other site 452652013289 active site 452652013290 catalytic residue [active] 452652013291 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 452652013292 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 452652013293 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 452652013294 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 452652013295 active site 452652013296 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 452652013297 putative Zn2+ binding site [ion binding]; other site 452652013298 putative DNA binding site [nucleotide binding]; other site 452652013299 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 452652013300 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 452652013301 Walker A/P-loop; other site 452652013302 ATP binding site [chemical binding]; other site 452652013303 Q-loop/lid; other site 452652013304 ABC transporter signature motif; other site 452652013305 Walker B; other site 452652013306 D-loop; other site 452652013307 H-loop/switch region; other site 452652013308 Predicted transcriptional regulators [Transcription]; Region: COG1725 452652013309 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 452652013310 DNA-binding site [nucleotide binding]; DNA binding site 452652013311 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 452652013312 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 452652013313 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 452652013314 PAS domain; Region: PAS_9; pfam13426 452652013315 putative active site [active] 452652013316 heme pocket [chemical binding]; other site 452652013317 GAF domain; Region: GAF; pfam01590 452652013318 GAF domain; Region: GAF_2; pfam13185 452652013319 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 452652013320 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 452652013321 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 452652013322 dimerization interface [polypeptide binding]; other site 452652013323 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 452652013324 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 452652013325 dimerization interface [polypeptide binding]; other site 452652013326 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 452652013327 dimerization interface [polypeptide binding]; other site 452652013328 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 452652013329 dimerization interface [polypeptide binding]; other site 452652013330 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 452652013331 dimerization interface [polypeptide binding]; other site 452652013332 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 452652013333 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 452652013334 dimerization interface [polypeptide binding]; other site 452652013335 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 452652013336 dimerization interface [polypeptide binding]; other site 452652013337 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 452652013338 GAF domain; Region: GAF_2; pfam13185 452652013339 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 452652013340 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652013341 ATP binding site [chemical binding]; other site 452652013342 Mg2+ binding site [ion binding]; other site 452652013343 G-X-G motif; other site 452652013344 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 452652013345 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652013346 active site 452652013347 phosphorylation site [posttranslational modification] 452652013348 intermolecular recognition site; other site 452652013349 dimerization interface [polypeptide binding]; other site 452652013350 Response regulator receiver domain; Region: Response_reg; pfam00072 452652013351 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652013352 active site 452652013353 phosphorylation site [posttranslational modification] 452652013354 intermolecular recognition site; other site 452652013355 dimerization interface [polypeptide binding]; other site 452652013356 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 452652013357 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 452652013358 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 452652013359 Helix-turn-helix domain; Region: HTH_25; pfam13413 452652013360 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 452652013361 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 452652013362 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 452652013363 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 452652013364 FeS/SAM binding site; other site 452652013365 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 452652013366 Competence-damaged protein; Region: CinA; pfam02464 452652013367 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 452652013368 sequence-specific DNA binding site [nucleotide binding]; other site 452652013369 salt bridge; other site 452652013370 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 452652013371 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 452652013372 ATP binding site [chemical binding]; other site 452652013373 putative Mg++ binding site [ion binding]; other site 452652013374 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 452652013375 nucleotide binding region [chemical binding]; other site 452652013376 ATP-binding site [chemical binding]; other site 452652013377 DEAD/H associated; Region: DEAD_assoc; pfam08494 452652013378 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 452652013379 active site 452652013380 catalytic residues [active] 452652013381 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 452652013382 Domain of unknown function DUF20; Region: UPF0118; pfam01594 452652013383 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 452652013384 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 452652013385 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652013386 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452652013387 DNA binding residues [nucleotide binding] 452652013388 recombinase A; Provisional; Region: recA; PRK09354 452652013389 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 452652013390 hexamer interface [polypeptide binding]; other site 452652013391 Walker A motif; other site 452652013392 ATP binding site [chemical binding]; other site 452652013393 Walker B motif; other site 452652013394 recombination regulator RecX; Reviewed; Region: recX; PRK00117 452652013395 KH domain; Region: KH_1; pfam00013 452652013396 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 452652013397 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 452652013398 Zn2+ binding site [ion binding]; other site 452652013399 Mg2+ binding site [ion binding]; other site 452652013400 FAD binding domain; Region: FAD_binding_3; pfam01494 452652013401 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 452652013402 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 452652013403 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652013404 dimer interface [polypeptide binding]; other site 452652013405 conserved gate region; other site 452652013406 putative PBP binding loops; other site 452652013407 ABC-ATPase subunit interface; other site 452652013408 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652013409 dimer interface [polypeptide binding]; other site 452652013410 conserved gate region; other site 452652013411 ABC-ATPase subunit interface; other site 452652013412 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 452652013413 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 452652013414 substrate binding pocket [chemical binding]; other site 452652013415 membrane-bound complex binding site; other site 452652013416 hinge residues; other site 452652013417 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 452652013418 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 452652013419 Walker A/P-loop; other site 452652013420 ATP binding site [chemical binding]; other site 452652013421 Q-loop/lid; other site 452652013422 ABC transporter signature motif; other site 452652013423 Walker B; other site 452652013424 D-loop; other site 452652013425 H-loop/switch region; other site 452652013426 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652013427 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 452652013428 active site 452652013429 phosphorylation site [posttranslational modification] 452652013430 intermolecular recognition site; other site 452652013431 dimerization interface [polypeptide binding]; other site 452652013432 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 452652013433 DNA binding site [nucleotide binding] 452652013434 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452652013435 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 452652013436 dimerization interface [polypeptide binding]; other site 452652013437 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452652013438 dimer interface [polypeptide binding]; other site 452652013439 phosphorylation site [posttranslational modification] 452652013440 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652013441 ATP binding site [chemical binding]; other site 452652013442 Mg2+ binding site [ion binding]; other site 452652013443 G-X-G motif; other site 452652013444 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 452652013445 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 452652013446 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 452652013447 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 452652013448 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 452652013449 FeS/SAM binding site; other site 452652013450 TRAM domain; Region: TRAM; cl01282 452652013451 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 452652013452 active site 452652013453 metal binding site [ion binding]; metal-binding site 452652013454 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 452652013455 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 452652013456 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 452652013457 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 452652013458 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 452652013459 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 452652013460 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 452652013461 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 452652013462 Zn2+ binding site [ion binding]; other site 452652013463 Mg2+ binding site [ion binding]; other site 452652013464 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 452652013465 synthetase active site [active] 452652013466 NTP binding site [chemical binding]; other site 452652013467 metal binding site [ion binding]; metal-binding site 452652013468 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 452652013469 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 452652013470 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 452652013471 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 452652013472 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 452652013473 HflX GTPase family; Region: HflX; cd01878 452652013474 G1 box; other site 452652013475 GTP/Mg2+ binding site [chemical binding]; other site 452652013476 Switch I region; other site 452652013477 G2 box; other site 452652013478 G3 box; other site 452652013479 Switch II region; other site 452652013480 G4 box; other site 452652013481 G5 box; other site 452652013482 The Death Domain Superfamily of protein-protein interaction domains; Region: DD_superfamily; cl14633 452652013483 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 452652013484 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 452652013485 IucA / IucC family; Region: IucA_IucC; pfam04183 452652013486 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 452652013487 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 452652013488 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 452652013489 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 452652013490 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 452652013491 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 452652013492 IucA / IucC family; Region: IucA_IucC; pfam04183 452652013493 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 452652013494 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 452652013495 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 452652013496 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 452652013497 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 452652013498 LexA repressor; Validated; Region: PRK00215 452652013499 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 452652013500 Catalytic site [active] 452652013501 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 452652013502 ATP cone domain; Region: ATP-cone; pfam03477 452652013503 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 452652013504 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 452652013505 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 452652013506 active site 452652013507 dimer interface [polypeptide binding]; other site 452652013508 effector binding site; other site 452652013509 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 452652013510 TSCPD domain; Region: TSCPD; pfam12637 452652013511 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652013512 NADH(P)-binding; Region: NAD_binding_10; pfam13460 452652013513 NAD(P) binding site [chemical binding]; other site 452652013514 active site 452652013515 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 452652013516 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 452652013517 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652013518 dimer interface [polypeptide binding]; other site 452652013519 putative PBP binding loops; other site 452652013520 ABC-ATPase subunit interface; other site 452652013521 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 452652013522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652013523 dimer interface [polypeptide binding]; other site 452652013524 conserved gate region; other site 452652013525 putative PBP binding loops; other site 452652013526 ABC-ATPase subunit interface; other site 452652013527 Bacterial Ig-like domain; Region: Big_5; pfam13205 452652013528 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 452652013529 RNA/DNA hybrid binding site [nucleotide binding]; other site 452652013530 active site 452652013531 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 452652013532 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 452652013533 ATP binding site [chemical binding]; other site 452652013534 putative Mg++ binding site [ion binding]; other site 452652013535 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 452652013536 nucleotide binding region [chemical binding]; other site 452652013537 ATP-binding site [chemical binding]; other site 452652013538 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 452652013539 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 452652013540 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 452652013541 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 452652013542 nudix motif; other site 452652013543 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 452652013544 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652013545 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 452652013546 Walker A/P-loop; other site 452652013547 ATP binding site [chemical binding]; other site 452652013548 Q-loop/lid; other site 452652013549 ABC transporter signature motif; other site 452652013550 Walker B; other site 452652013551 D-loop; other site 452652013552 H-loop/switch region; other site 452652013553 Transcriptional regulators [Transcription]; Region: FadR; COG2186 452652013554 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 452652013555 DNA-binding site [nucleotide binding]; DNA binding site 452652013556 FCD domain; Region: FCD; pfam07729 452652013557 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 452652013558 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 452652013559 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652013560 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 452652013561 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452652013562 DNA binding residues [nucleotide binding] 452652013563 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 452652013564 cleavage site 452652013565 active site 452652013566 substrate binding sites [chemical binding]; other site 452652013567 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 452652013568 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652013569 ATP binding site [chemical binding]; other site 452652013570 Mg2+ binding site [ion binding]; other site 452652013571 G-X-G motif; other site 452652013572 DNA gyrase B; Region: DNA_gyraseB; pfam00204 452652013573 ATP binding site [chemical binding]; other site 452652013574 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 452652013575 active site 452652013576 metal binding site [ion binding]; metal-binding site 452652013577 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 452652013578 Histidine kinase; Region: HisKA_3; pfam07730 452652013579 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 452652013580 Mg2+ binding site [ion binding]; other site 452652013581 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652013582 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652013583 active site 452652013584 phosphorylation site [posttranslational modification] 452652013585 intermolecular recognition site; other site 452652013586 dimerization interface [polypeptide binding]; other site 452652013587 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652013588 DNA binding residues [nucleotide binding] 452652013589 dimerization interface [polypeptide binding]; other site 452652013590 Protein of unknown function, DUF485; Region: DUF485; pfam04341 452652013591 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 452652013592 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 452652013593 Na binding site [ion binding]; other site 452652013594 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 452652013595 putative dimer interface [polypeptide binding]; other site 452652013596 putative [2Fe-2S] cluster binding site [ion binding]; other site 452652013597 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 452652013598 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 452652013599 CAP-like domain; other site 452652013600 active site 452652013601 primary dimer interface [polypeptide binding]; other site 452652013602 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 452652013603 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 452652013604 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 452652013605 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 452652013606 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 452652013607 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 452652013608 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 452652013609 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 452652013610 hypothetical protein; Reviewed; Region: PRK09588 452652013611 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 452652013612 dimerization domain swap beta strand [polypeptide binding]; other site 452652013613 regulatory protein interface [polypeptide binding]; other site 452652013614 active site 452652013615 regulatory phosphorylation site [posttranslational modification]; other site 452652013616 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 452652013617 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452652013618 Coenzyme A binding pocket [chemical binding]; other site 452652013619 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 452652013620 CoA binding domain; Region: CoA_binding; smart00881 452652013621 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 452652013622 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 452652013623 PglZ domain; Region: PglZ; pfam08665 452652013624 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 452652013625 thymidine kinase; Provisional; Region: PRK04296 452652013626 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 452652013627 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 452652013628 active site residue [active] 452652013629 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 452652013630 active site residue [active] 452652013631 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 452652013632 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 452652013633 FAD binding domain; Region: FAD_binding_4; pfam01565 452652013634 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 452652013635 ferrochelatase; Reviewed; Region: hemH; PRK00035 452652013636 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 452652013637 C-terminal domain interface [polypeptide binding]; other site 452652013638 active site 452652013639 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 452652013640 active site 452652013641 N-terminal domain interface [polypeptide binding]; other site 452652013642 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 452652013643 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 452652013644 active site 452652013645 dimerization interface [polypeptide binding]; other site 452652013646 Oxysterol-binding protein; Region: Oxysterol_BP; pfam01237 452652013647 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 452652013648 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652013649 active site 452652013650 phosphorylation site [posttranslational modification] 452652013651 intermolecular recognition site; other site 452652013652 dimerization interface [polypeptide binding]; other site 452652013653 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 452652013654 DNA binding site [nucleotide binding] 452652013655 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452652013656 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 452652013657 dimerization interface [polypeptide binding]; other site 452652013658 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452652013659 dimer interface [polypeptide binding]; other site 452652013660 phosphorylation site [posttranslational modification] 452652013661 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652013662 ATP binding site [chemical binding]; other site 452652013663 Mg2+ binding site [ion binding]; other site 452652013664 G-X-G motif; other site 452652013665 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 452652013666 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 452652013667 homodimer interface [polypeptide binding]; other site 452652013668 putative substrate binding pocket [chemical binding]; other site 452652013669 diiron center [ion binding]; other site 452652013670 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 452652013671 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 452652013672 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 452652013673 CoenzymeA binding site [chemical binding]; other site 452652013674 subunit interaction site [polypeptide binding]; other site 452652013675 PHB binding site; other site 452652013676 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 452652013677 trimer interface [polypeptide binding]; other site 452652013678 active site 452652013679 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 452652013680 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 452652013681 AAA domain; Region: AAA_30; pfam13604 452652013682 Family description; Region: UvrD_C_2; pfam13538 452652013683 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 452652013684 dimer interface [polypeptide binding]; other site 452652013685 Citrate synthase; Region: Citrate_synt; pfam00285 452652013686 active site 452652013687 citrylCoA binding site [chemical binding]; other site 452652013688 NADH binding [chemical binding]; other site 452652013689 cationic pore residues; other site 452652013690 oxalacetate/citrate binding site [chemical binding]; other site 452652013691 coenzyme A binding site [chemical binding]; other site 452652013692 catalytic triad [active] 452652013693 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 452652013694 classical (c) SDRs; Region: SDR_c; cd05233 452652013695 NAD(P) binding site [chemical binding]; other site 452652013696 active site 452652013697 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 452652013698 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 452652013699 metal-binding site [ion binding] 452652013700 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 452652013701 Soluble P-type ATPase [General function prediction only]; Region: COG4087 452652013702 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 452652013703 metal-binding site [ion binding] 452652013704 Protease prsW family; Region: PrsW-protease; pfam13367 452652013705 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 452652013706 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 452652013707 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 452652013708 active site 452652013709 DNA binding site [nucleotide binding] 452652013710 catalytic site [active] 452652013711 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 452652013712 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 452652013713 active site 452652013714 Zn binding site [ion binding]; other site 452652013715 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652013716 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652013717 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 452652013718 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 452652013719 active site 452652013720 enoyl-CoA hydratase; Provisional; Region: PRK06127 452652013721 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 452652013722 substrate binding site [chemical binding]; other site 452652013723 oxyanion hole (OAH) forming residues; other site 452652013724 trimer interface [polypeptide binding]; other site 452652013725 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 452652013726 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 452652013727 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 452652013728 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652013729 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 452652013730 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 452652013731 dimer interface [polypeptide binding]; other site 452652013732 ssDNA binding site [nucleotide binding]; other site 452652013733 tetramer (dimer of dimers) interface [polypeptide binding]; other site 452652013734 TQXA domain; Region: TQXA_dom; TIGR03934 452652013735 Domain of unknown function (DUF756); Region: DUF756; pfam05506 452652013736 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 452652013737 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652013738 Walker A/P-loop; other site 452652013739 ATP binding site [chemical binding]; other site 452652013740 Q-loop/lid; other site 452652013741 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 452652013742 ABC transporter; Region: ABC_tran_2; pfam12848 452652013743 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 452652013744 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 452652013745 active site 452652013746 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 452652013747 apolar tunnel; other site 452652013748 heme binding site [chemical binding]; other site 452652013749 dimerization interface [polypeptide binding]; other site 452652013750 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 452652013751 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 452652013752 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 452652013753 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 452652013754 Walker A/P-loop; other site 452652013755 ATP binding site [chemical binding]; other site 452652013756 Q-loop/lid; other site 452652013757 ABC transporter signature motif; other site 452652013758 Walker B; other site 452652013759 D-loop; other site 452652013760 H-loop/switch region; other site 452652013761 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 452652013762 phosphopeptide binding site; other site 452652013763 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 452652013764 metal ion-dependent adhesion site (MIDAS); other site 452652013765 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 452652013766 Double zinc ribbon; Region: DZR; pfam12773 452652013767 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 452652013768 active site 452652013769 Protein kinase domain; Region: Pkinase; pfam00069 452652013770 Catalytic domain of Protein Kinases; Region: PKc; cd00180 452652013771 active site 452652013772 ATP binding site [chemical binding]; other site 452652013773 substrate binding site [chemical binding]; other site 452652013774 activation loop (A-loop); other site 452652013775 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 452652013776 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 452652013777 substrate binding pocket [chemical binding]; other site 452652013778 membrane-bound complex binding site; other site 452652013779 hinge residues; other site 452652013780 nucleosidase; Provisional; Region: PRK05634 452652013781 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 452652013782 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 452652013783 legume lectins; Region: lectin_L-type; cl14058 452652013784 homotetramer interaction site [polypeptide binding]; other site 452652013785 carbohydrate binding site [chemical binding]; other site 452652013786 metal binding site [ion binding]; metal-binding site 452652013787 Domain of unknown function DUF11; Region: DUF11; pfam01345 452652013788 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 452652013789 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 452652013790 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 452652013791 NAD binding site [chemical binding]; other site 452652013792 sugar binding site [chemical binding]; other site 452652013793 divalent metal binding site [ion binding]; other site 452652013794 tetramer (dimer of dimers) interface [polypeptide binding]; other site 452652013795 dimer interface [polypeptide binding]; other site 452652013796 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 452652013797 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652013798 dimer interface [polypeptide binding]; other site 452652013799 conserved gate region; other site 452652013800 putative PBP binding loops; other site 452652013801 ABC-ATPase subunit interface; other site 452652013802 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652013803 dimer interface [polypeptide binding]; other site 452652013804 conserved gate region; other site 452652013805 putative PBP binding loops; other site 452652013806 ABC-ATPase subunit interface; other site 452652013807 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 452652013808 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 452652013809 putative DNA binding site [nucleotide binding]; other site 452652013810 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 452652013811 putative Zn2+ binding site [ion binding]; other site 452652013812 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 452652013813 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 452652013814 nucleotide binding site [chemical binding]; other site 452652013815 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 452652013816 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652013817 NAD(P) binding site [chemical binding]; other site 452652013818 active site 452652013819 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 452652013820 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652013821 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652013822 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 452652013823 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 452652013824 active site 452652013825 ATP binding site [chemical binding]; other site 452652013826 substrate binding site [chemical binding]; other site 452652013827 activation loop (A-loop); other site 452652013828 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 452652013829 Mechanosensitive ion channel; Region: MS_channel; pfam00924 452652013830 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 452652013831 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 452652013832 active site 452652013833 beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555 452652013834 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 452652013835 sugar binding site [chemical binding]; other site 452652013836 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 452652013837 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 452652013838 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 452652013839 ApbE family; Region: ApbE; pfam02424 452652013840 FMN-binding domain; Region: FMN_bind; cl01081 452652013841 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 452652013842 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 452652013843 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 452652013844 FAD binding pocket [chemical binding]; other site 452652013845 conserved FAD binding motif [chemical binding]; other site 452652013846 phosphate binding motif [ion binding]; other site 452652013847 beta-alpha-beta structure motif; other site 452652013848 NAD binding pocket [chemical binding]; other site 452652013849 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 452652013850 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652013851 active site 452652013852 phosphorylation site [posttranslational modification] 452652013853 intermolecular recognition site; other site 452652013854 dimerization interface [polypeptide binding]; other site 452652013855 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 452652013856 DNA binding site [nucleotide binding] 452652013857 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452652013858 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452652013859 dimer interface [polypeptide binding]; other site 452652013860 phosphorylation site [posttranslational modification] 452652013861 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652013862 ATP binding site [chemical binding]; other site 452652013863 Mg2+ binding site [ion binding]; other site 452652013864 G-X-G motif; other site 452652013865 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 452652013866 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 452652013867 Zn binding site [ion binding]; other site 452652013868 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 452652013869 non-specific DNA interactions [nucleotide binding]; other site 452652013870 DNA binding site [nucleotide binding] 452652013871 sequence specific DNA binding site [nucleotide binding]; other site 452652013872 putative cAMP binding site [chemical binding]; other site 452652013873 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 452652013874 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 452652013875 nucleotide binding site [chemical binding]; other site 452652013876 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 452652013877 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 452652013878 putative ligand binding site [chemical binding]; other site 452652013879 D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634 452652013880 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 452652013881 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 452652013882 Walker A/P-loop; other site 452652013883 ATP binding site [chemical binding]; other site 452652013884 Q-loop/lid; other site 452652013885 ABC transporter signature motif; other site 452652013886 Walker B; other site 452652013887 D-loop; other site 452652013888 H-loop/switch region; other site 452652013889 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 452652013890 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 452652013891 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 452652013892 TM-ABC transporter signature motif; other site 452652013893 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12571 452652013894 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 452652013895 TPP-binding site; other site 452652013896 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 452652013897 PYR/PP interface [polypeptide binding]; other site 452652013898 dimer interface [polypeptide binding]; other site 452652013899 TPP binding site [chemical binding]; other site 452652013900 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 452652013901 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 452652013902 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 452652013903 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 452652013904 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 452652013905 catalytic site [active] 452652013906 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 452652013907 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 452652013908 substrate binding site [chemical binding]; other site 452652013909 oxyanion hole (OAH) forming residues; other site 452652013910 trimer interface [polypeptide binding]; other site 452652013911 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 452652013912 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 452652013913 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 452652013914 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 452652013915 dimer interface [polypeptide binding]; other site 452652013916 active site 452652013917 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 452652013918 catalytic site [active] 452652013919 putative active site [active] 452652013920 putative substrate binding site [chemical binding]; other site 452652013921 HRDC domain; Region: HRDC; cl02578 452652013922 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652013923 active site 452652013924 phosphorylation site [posttranslational modification] 452652013925 intermolecular recognition site; other site 452652013926 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652013927 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652013928 DNA binding residues [nucleotide binding] 452652013929 dimerization interface [polypeptide binding]; other site 452652013930 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 452652013931 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 452652013932 substrate binding site [chemical binding]; other site 452652013933 active site 452652013934 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 452652013935 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 452652013936 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 452652013937 TIGR04222 domain; Region: near_uncomplex 452652013938 TIGR04222 domain; Region: near_uncomplex 452652013939 hypothetical protein; Provisional; Region: PRK05409 452652013940 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 452652013941 Restriction endonuclease; Region: Mrr_cat; pfam04471 452652013942 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 452652013943 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 452652013944 SelR domain; Region: SelR; pfam01641 452652013945 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 452652013946 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 452652013947 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 452652013948 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 452652013949 hypothetical protein; Provisional; Region: PRK14059 452652013950 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 452652013951 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 452652013952 excinuclease ABC subunit B; Provisional; Region: PRK05298 452652013953 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 452652013954 putative Mg++ binding site [ion binding]; other site 452652013955 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 452652013956 nucleotide binding region [chemical binding]; other site 452652013957 ATP-binding site [chemical binding]; other site 452652013958 Ultra-violet resistance protein B; Region: UvrB; pfam12344 452652013959 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 452652013960 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 452652013961 putative metal binding site [ion binding]; other site 452652013962 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 452652013963 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 452652013964 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 452652013965 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 452652013966 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 452652013967 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 452652013968 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 452652013969 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 452652013970 iron-sulfur cluster [ion binding]; other site 452652013971 [2Fe-2S] cluster binding site [ion binding]; other site 452652013972 Hyaluronidase protein (HylP); Region: Hyaluronidase_1; pfam07212 452652013973 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 452652013974 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 452652013975 GIY-YIG motif/motif A; other site 452652013976 active site 452652013977 catalytic site [active] 452652013978 putative DNA binding site [nucleotide binding]; other site 452652013979 metal binding site [ion binding]; metal-binding site 452652013980 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 452652013981 Helix-hairpin-helix motif; Region: HHH; pfam00633 452652013982 helix-hairpin-helix signature motif; other site 452652013983 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 452652013984 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 452652013985 putative substrate binding pocket [chemical binding]; other site 452652013986 dimer interface [polypeptide binding]; other site 452652013987 phosphate binding site [ion binding]; other site 452652013988 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 452652013989 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 452652013990 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 452652013991 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 452652013992 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 452652013993 Phosphoglycerate kinase; Region: PGK; pfam00162 452652013994 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 452652013995 substrate binding site [chemical binding]; other site 452652013996 hinge regions; other site 452652013997 ADP binding site [chemical binding]; other site 452652013998 catalytic site [active] 452652013999 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 452652014000 triosephosphate isomerase; Provisional; Region: PRK14567 452652014001 substrate binding site [chemical binding]; other site 452652014002 dimer interface [polypeptide binding]; other site 452652014003 catalytic triad [active] 452652014004 Preprotein translocase SecG subunit; Region: SecG; pfam03840 452652014005 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 452652014006 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 452652014007 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 452652014008 putative active site [active] 452652014009 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 452652014010 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 452652014011 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 452652014012 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 452652014013 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 452652014014 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 452652014015 putative active site [active] 452652014016 transaldolase; Provisional; Region: PRK03903 452652014017 catalytic residue [active] 452652014018 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 452652014019 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 452652014020 TPP-binding site [chemical binding]; other site 452652014021 dimer interface [polypeptide binding]; other site 452652014022 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 452652014023 PYR/PP interface [polypeptide binding]; other site 452652014024 dimer interface [polypeptide binding]; other site 452652014025 TPP binding site [chemical binding]; other site 452652014026 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 452652014027 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 452652014028 UbiA prenyltransferase family; Region: UbiA; pfam01040 452652014029 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 452652014030 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 452652014031 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 452652014032 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 452652014033 MarR family; Region: MarR; pfam01047 452652014034 Nitroreductase [Energy production and conversion]; Region: NfnB; COG0778 452652014035 FMN binding site [chemical binding]; other site 452652014036 dimer interface [polypeptide binding]; other site 452652014037 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 452652014038 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 452652014039 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 452652014040 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 452652014041 ABC-2 type transporter; Region: ABC2_membrane; cl17235 452652014042 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 452652014043 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 452652014044 Walker A/P-loop; other site 452652014045 ATP binding site [chemical binding]; other site 452652014046 Q-loop/lid; other site 452652014047 ABC transporter signature motif; other site 452652014048 Walker B; other site 452652014049 D-loop; other site 452652014050 H-loop/switch region; other site 452652014051 Predicted transcriptional regulator [Transcription]; Region: COG2345 452652014052 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 452652014053 FeS assembly protein SufB; Region: sufB; TIGR01980 452652014054 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 452652014055 FeS assembly protein SufD; Region: sufD; TIGR01981 452652014056 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 452652014057 [2Fe-2S] cluster binding site [ion binding]; other site 452652014058 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 452652014059 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 452652014060 Walker A/P-loop; other site 452652014061 ATP binding site [chemical binding]; other site 452652014062 Q-loop/lid; other site 452652014063 ABC transporter signature motif; other site 452652014064 Walker B; other site 452652014065 D-loop; other site 452652014066 H-loop/switch region; other site 452652014067 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 452652014068 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 452652014069 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 452652014070 catalytic residue [active] 452652014071 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 452652014072 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 452652014073 trimerization site [polypeptide binding]; other site 452652014074 active site 452652014075 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 452652014076 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 452652014077 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 452652014078 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 452652014079 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 452652014080 Glutamate binding site [chemical binding]; other site 452652014081 NAD binding site [chemical binding]; other site 452652014082 catalytic residues [active] 452652014083 Proline dehydrogenase; Region: Pro_dh; cl03282 452652014084 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 452652014085 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 452652014086 putative metal binding site [ion binding]; other site 452652014087 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 452652014088 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 452652014089 putative metal binding site [ion binding]; other site 452652014090 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 452652014091 Peptidase family M1; Region: Peptidase_M1; pfam01433 452652014092 Zn binding site [ion binding]; other site 452652014093 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 452652014094 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 452652014095 Penicillinase repressor; Region: Pencillinase_R; cl17580 452652014096 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 452652014097 active site 452652014098 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 452652014099 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3787; cl17897 452652014100 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 452652014101 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 452652014102 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 452652014103 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 452652014104 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 452652014105 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 452652014106 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 452652014107 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 452652014108 active site 452652014109 motif I; other site 452652014110 motif II; other site 452652014111 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 452652014112 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652014113 Walker A/P-loop; other site 452652014114 ATP binding site [chemical binding]; other site 452652014115 Q-loop/lid; other site 452652014116 ABC transporter signature motif; other site 452652014117 Walker B; other site 452652014118 D-loop; other site 452652014119 H-loop/switch region; other site 452652014120 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 452652014121 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652014122 ABC-ATPase subunit interface; other site 452652014123 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 452652014124 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 452652014125 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 452652014126 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 452652014127 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 452652014128 DNA-binding site [nucleotide binding]; DNA binding site 452652014129 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 452652014130 PemK-like protein; Region: PemK; pfam02452 452652014131 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 452652014132 homotrimer interaction site [polypeptide binding]; other site 452652014133 putative active site [active] 452652014134 gamma-butyrobetaine hydroxylase; Region: carnitine_bodg; TIGR02409 452652014135 Protein of unknown function (DUF971); Region: DUF971; cl01414 452652014136 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 452652014137 substrate binding pocket [chemical binding]; other site 452652014138 active site 452652014139 iron coordination sites [ion binding]; other site 452652014140 Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564 452652014141 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 452652014142 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652014143 NAD(P) binding site [chemical binding]; other site 452652014144 active site 452652014145 Transcriptional regulator [Transcription]; Region: LysR; COG0583 452652014146 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 452652014147 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 452652014148 dimerization interface [polypeptide binding]; other site 452652014149 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 452652014150 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 452652014151 catalytic residue [active] 452652014152 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 452652014153 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 452652014154 active site 452652014155 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 452652014156 ligand binding site [chemical binding]; other site 452652014157 active site 452652014158 UGI interface [polypeptide binding]; other site 452652014159 catalytic site [active] 452652014160 glutamine synthetase; Region: PLN02284 452652014161 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 452652014162 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 452652014163 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 452652014164 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 452652014165 DNA binding residues [nucleotide binding] 452652014166 Peptidase family M48; Region: Peptidase_M48; cl12018 452652014167 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 452652014168 Methyltransferase domain; Region: Methyltransf_23; pfam13489 452652014169 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652014170 S-adenosylmethionine binding site [chemical binding]; other site 452652014171 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652014172 non-specific DNA binding site [nucleotide binding]; other site 452652014173 salt bridge; other site 452652014174 sequence-specific DNA binding site [nucleotide binding]; other site 452652014175 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 452652014176 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 452652014177 MOSC domain; Region: MOSC; pfam03473 452652014178 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 452652014179 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652014180 homodimer interface [polypeptide binding]; other site 452652014181 catalytic residue [active] 452652014182 Phosphoesterase family; Region: Phosphoesterase; pfam04185 452652014183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652014184 Major Facilitator Superfamily; Region: MFS_1; pfam07690 452652014185 putative substrate translocation pore; other site 452652014186 translocation protein TolB; Provisional; Region: tolB; PRK02889 452652014187 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452652014188 Coenzyme A binding pocket [chemical binding]; other site 452652014189 MarR family; Region: MarR_2; cl17246 452652014190 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 452652014191 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 452652014192 Walker A/P-loop; other site 452652014193 ATP binding site [chemical binding]; other site 452652014194 Q-loop/lid; other site 452652014195 ABC transporter signature motif; other site 452652014196 Walker B; other site 452652014197 D-loop; other site 452652014198 H-loop/switch region; other site 452652014199 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 452652014200 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 452652014201 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 452652014202 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 452652014203 TAP-like protein; Region: Abhydrolase_4; pfam08386 452652014204 OsmC-like protein; Region: OsmC; cl00767 452652014205 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 452652014206 FCD domain; Region: FCD; pfam07729 452652014207 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 452652014208 Septum formation; Region: Septum_form; pfam13845 452652014209 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 452652014210 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 452652014211 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 452652014212 catalytic triad [active] 452652014213 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 452652014214 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 452652014215 homodimer interface [polypeptide binding]; other site 452652014216 Walker A motif; other site 452652014217 ATP binding site [chemical binding]; other site 452652014218 hydroxycobalamin binding site [chemical binding]; other site 452652014219 Walker B motif; other site 452652014220 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 452652014221 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 452652014222 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 452652014223 metal ion-dependent adhesion site (MIDAS); other site 452652014224 cobyric acid synthase; Provisional; Region: PRK00784 452652014225 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 452652014226 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 452652014227 catalytic triad [active] 452652014228 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 452652014229 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 452652014230 Eukaryotic protein of unknown function (DUF829); Region: DUF829; pfam05705 452652014231 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 452652014232 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 452652014233 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 452652014234 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 452652014235 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 452652014236 active site 452652014237 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 452652014238 putative active site [active] 452652014239 putative catalytic site [active] 452652014240 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 452652014241 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 452652014242 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 452652014243 B12 binding site [chemical binding]; other site 452652014244 cobalt ligand [ion binding]; other site 452652014245 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 452652014246 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 452652014247 NAD(P) binding site [chemical binding]; other site 452652014248 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 452652014249 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652014250 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 452652014251 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 452652014252 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 452652014253 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 452652014254 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 452652014255 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 452652014256 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 452652014257 putative active site [active] 452652014258 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 452652014259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652014260 putative substrate translocation pore; other site 452652014261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652014262 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652014263 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652014264 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 452652014265 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 452652014266 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 452652014267 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652014268 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452652014269 DNA binding residues [nucleotide binding] 452652014270 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 452652014271 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 452652014272 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 452652014273 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 452652014274 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 452652014275 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 452652014276 dimer interface [polypeptide binding]; other site 452652014277 ADP-ribose binding site [chemical binding]; other site 452652014278 active site 452652014279 nudix motif; other site 452652014280 metal binding site [ion binding]; metal-binding site 452652014281 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 452652014282 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 452652014283 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 452652014284 Protein of unknown function (DUF2568); Region: DUF2568; pfam10823 452652014285 Cellulose binding domain; Region: CBM_2; pfam00553 452652014286 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 452652014287 Cellulose binding domain; Region: CBM_2; cl17741 452652014288 Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011 452652014289 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 452652014290 active site 452652014291 catalytic residues [active] 452652014292 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 452652014293 hydrophobic ligand binding site; other site 452652014294 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 452652014295 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 452652014296 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 452652014297 Bacterial sugar transferase; Region: Bac_transf; pfam02397 452652014298 O-Antigen ligase; Region: Wzy_C; pfam04932 452652014299 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 452652014300 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 452652014301 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 452652014302 putative active site [active] 452652014303 putative metal binding site [ion binding]; other site 452652014304 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 452652014305 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 452652014306 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 452652014307 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 452652014308 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 452652014309 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 452652014310 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 452652014311 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652014312 Walker A/P-loop; other site 452652014313 ATP binding site [chemical binding]; other site 452652014314 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 452652014315 ABC transporter signature motif; other site 452652014316 Walker B; other site 452652014317 D-loop; other site 452652014318 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 452652014319 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 452652014320 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 452652014321 substrate binding site [chemical binding]; other site 452652014322 oxyanion hole (OAH) forming residues; other site 452652014323 trimer interface [polypeptide binding]; other site 452652014324 Asp23 family; Region: Asp23; pfam03780 452652014325 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 452652014326 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652014327 NAD(P) binding site [chemical binding]; other site 452652014328 active site 452652014329 Right handed beta helix region; Region: Beta_helix; pfam13229 452652014330 PAS domain; Region: PAS; smart00091 452652014331 PAS fold; Region: PAS_4; pfam08448 452652014332 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 452652014333 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 452652014334 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652014335 Mg2+ binding site [ion binding]; other site 452652014336 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 452652014337 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 452652014338 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 452652014339 active site 452652014340 catalytic site [active] 452652014341 substrate binding site [chemical binding]; other site 452652014342 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 452652014343 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 452652014344 catalytic Zn binding site [ion binding]; other site 452652014345 NAD(P) binding site [chemical binding]; other site 452652014346 structural Zn binding site [ion binding]; other site 452652014347 Protein of unknown function, DUF485; Region: DUF485; pfam04341 452652014348 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 452652014349 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 452652014350 Na binding site [ion binding]; other site 452652014351 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 452652014352 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 452652014353 FeS/SAM binding site; other site 452652014354 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 452652014355 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 452652014356 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 452652014357 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 452652014358 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 452652014359 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 452652014360 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 452652014361 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 452652014362 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652014363 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 452652014364 NAD(P) binding site [chemical binding]; other site 452652014365 active site 452652014366 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 452652014367 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 452652014368 NAD binding site [chemical binding]; other site 452652014369 homotetramer interface [polypeptide binding]; other site 452652014370 homodimer interface [polypeptide binding]; other site 452652014371 substrate binding site [chemical binding]; other site 452652014372 active site 452652014373 Transcriptional regulators [Transcription]; Region: FadR; COG2186 452652014374 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 452652014375 DNA-binding site [nucleotide binding]; DNA binding site 452652014376 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 452652014377 cyanate transporter; Region: CynX; TIGR00896 452652014378 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652014379 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 452652014380 catalytic core [active] 452652014381 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 452652014382 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 452652014383 phosphoserine phosphatase SerB; Region: serB; TIGR00338 452652014384 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 452652014385 motif II; other site 452652014386 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 452652014387 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 452652014388 phosphopeptide binding site; other site 452652014389 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 452652014390 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 452652014391 phosphopeptide binding site; other site 452652014392 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 452652014393 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 452652014394 Walker A/P-loop; other site 452652014395 ATP binding site [chemical binding]; other site 452652014396 Q-loop/lid; other site 452652014397 ABC transporter signature motif; other site 452652014398 Walker B; other site 452652014399 D-loop; other site 452652014400 H-loop/switch region; other site 452652014401 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 452652014402 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 452652014403 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 452652014404 GAF domain; Region: GAF; pfam01590 452652014405 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 452652014406 Histidine kinase; Region: HisKA_3; pfam07730 452652014407 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652014408 ATP binding site [chemical binding]; other site 452652014409 Mg2+ binding site [ion binding]; other site 452652014410 G-X-G motif; other site 452652014411 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652014412 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652014413 active site 452652014414 phosphorylation site [posttranslational modification] 452652014415 intermolecular recognition site; other site 452652014416 dimerization interface [polypeptide binding]; other site 452652014417 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652014418 DNA binding residues [nucleotide binding] 452652014419 dimerization interface [polypeptide binding]; other site 452652014420 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 452652014421 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 452652014422 Walker A/P-loop; other site 452652014423 ATP binding site [chemical binding]; other site 452652014424 Q-loop/lid; other site 452652014425 ABC transporter signature motif; other site 452652014426 Walker B; other site 452652014427 D-loop; other site 452652014428 H-loop/switch region; other site 452652014429 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 452652014430 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 452652014431 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 452652014432 hypothetical protein; Provisional; Region: PRK10621 452652014433 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 452652014434 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 452652014435 aromatic arch; other site 452652014436 DCoH dimer interaction site [polypeptide binding]; other site 452652014437 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 452652014438 DCoH tetramer interaction site [polypeptide binding]; other site 452652014439 substrate binding site [chemical binding]; other site 452652014440 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 452652014441 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 452652014442 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 452652014443 active site 452652014444 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 452652014445 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 452652014446 active site 452652014447 HIGH motif; other site 452652014448 dimer interface [polypeptide binding]; other site 452652014449 KMSKS motif; other site 452652014450 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 452652014451 RNA binding surface [nucleotide binding]; other site 452652014452 Uncharacterized conserved protein [Function unknown]; Region: COG4198 452652014453 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 452652014454 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939 452652014455 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 452652014456 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 452652014457 active site 452652014458 motif I; other site 452652014459 motif II; other site 452652014460 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 452652014461 Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are...; Region: NDPk; cl00335 452652014462 SCP-2 sterol transfer family; Region: SCP2; pfam02036 452652014463 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 452652014464 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652014465 S-adenosylmethionine binding site [chemical binding]; other site 452652014466 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 452652014467 ATP-NAD kinase; Region: NAD_kinase; pfam01513 452652014468 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 452652014469 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 452652014470 DNA-binding site [nucleotide binding]; DNA binding site 452652014471 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 452652014472 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652014473 homodimer interface [polypeptide binding]; other site 452652014474 catalytic residue [active] 452652014475 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 452652014476 Predicted membrane protein [Function unknown]; Region: COG2364 452652014477 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 452652014478 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 452652014479 Walker A/P-loop; other site 452652014480 ATP binding site [chemical binding]; other site 452652014481 Q-loop/lid; other site 452652014482 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 452652014483 ABC transporter signature motif; other site 452652014484 Walker B; other site 452652014485 D-loop; other site 452652014486 H-loop/switch region; other site 452652014487 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 452652014488 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 452652014489 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 452652014490 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 452652014491 CTP synthetase; Validated; Region: pyrG; PRK05380 452652014492 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 452652014493 Catalytic site [active] 452652014494 active site 452652014495 UTP binding site [chemical binding]; other site 452652014496 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 452652014497 active site 452652014498 putative oxyanion hole; other site 452652014499 catalytic triad [active] 452652014500 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 452652014501 dimer interface [polypeptide binding]; other site 452652014502 ADP-ribose binding site [chemical binding]; other site 452652014503 active site 452652014504 nudix motif; other site 452652014505 metal binding site [ion binding]; metal-binding site 452652014506 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452652014507 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 452652014508 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 452652014509 hexamer interface [polypeptide binding]; other site 452652014510 ligand binding site [chemical binding]; other site 452652014511 putative active site [active] 452652014512 NAD(P) binding site [chemical binding]; other site 452652014513 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 452652014514 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 452652014515 P-loop; other site 452652014516 Magnesium ion binding site [ion binding]; other site 452652014517 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 452652014518 Magnesium ion binding site [ion binding]; other site 452652014519 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 452652014520 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 452652014521 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 452652014522 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 452652014523 RNA binding surface [nucleotide binding]; other site 452652014524 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 452652014525 active site 452652014526 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 452652014527 Predicted transcriptional regulators [Transcription]; Region: COG1378 452652014528 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 452652014529 dimerization interface [polypeptide binding]; other site 452652014530 DNA binding residues [nucleotide binding] 452652014531 Protein of unknown function (DUF952); Region: DUF952; pfam06108 452652014532 conserved hypothetical protein; Region: TIGR02231 452652014533 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 452652014534 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 452652014535 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 452652014536 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 452652014537 prephenate dehydrogenase; Validated; Region: PRK06545 452652014538 prephenate dehydrogenase; Validated; Region: PRK08507 452652014539 cytidylate kinase; Provisional; Region: cmk; PRK00023 452652014540 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 452652014541 CMP-binding site; other site 452652014542 The sites determining sugar specificity; other site 452652014543 GTP-binding protein Der; Reviewed; Region: PRK03003 452652014544 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 452652014545 G1 box; other site 452652014546 GTP/Mg2+ binding site [chemical binding]; other site 452652014547 Switch I region; other site 452652014548 G2 box; other site 452652014549 Switch II region; other site 452652014550 G3 box; other site 452652014551 G4 box; other site 452652014552 G5 box; other site 452652014553 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 452652014554 G1 box; other site 452652014555 GTP/Mg2+ binding site [chemical binding]; other site 452652014556 Switch I region; other site 452652014557 G2 box; other site 452652014558 G3 box; other site 452652014559 Switch II region; other site 452652014560 G4 box; other site 452652014561 G5 box; other site 452652014562 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 452652014563 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 452652014564 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 452652014565 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652014566 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652014567 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 452652014568 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 452652014569 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 452652014570 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 452652014571 active site 452652014572 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 452652014573 catalytic triad [active] 452652014574 dimer interface [polypeptide binding]; other site 452652014575 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 452652014576 Transcriptional regulators [Transcription]; Region: PurR; COG1609 452652014577 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 452652014578 DNA binding site [nucleotide binding] 452652014579 domain linker motif; other site 452652014580 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 452652014581 putative dimerization interface [polypeptide binding]; other site 452652014582 putative ligand binding site [chemical binding]; other site 452652014583 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 452652014584 Phosphotransferase enzyme family; Region: APH; pfam01636 452652014585 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 452652014586 active site 452652014587 substrate binding site [chemical binding]; other site 452652014588 ATP binding site [chemical binding]; other site 452652014589 Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310 452652014590 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 452652014591 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652014592 dimer interface [polypeptide binding]; other site 452652014593 conserved gate region; other site 452652014594 putative PBP binding loops; other site 452652014595 ABC-ATPase subunit interface; other site 452652014596 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 452652014597 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652014598 dimer interface [polypeptide binding]; other site 452652014599 conserved gate region; other site 452652014600 putative PBP binding loops; other site 452652014601 ABC-ATPase subunit interface; other site 452652014602 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 452652014603 beta-galactosidase; Region: BGL; TIGR03356 452652014604 elongation factor G; Reviewed; Region: PRK13351 452652014605 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 452652014606 G1 box; other site 452652014607 putative GEF interaction site [polypeptide binding]; other site 452652014608 GTP/Mg2+ binding site [chemical binding]; other site 452652014609 Switch I region; other site 452652014610 G2 box; other site 452652014611 G3 box; other site 452652014612 Switch II region; other site 452652014613 G4 box; other site 452652014614 G5 box; other site 452652014615 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 452652014616 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 452652014617 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 452652014618 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 452652014619 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652014620 dimerization interface [polypeptide binding]; other site 452652014621 DNA binding residues [nucleotide binding] 452652014622 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 452652014623 ATP binding site [chemical binding]; other site 452652014624 putative Mg++ binding site [ion binding]; other site 452652014625 nucleotide binding region [chemical binding]; other site 452652014626 helicase superfamily c-terminal domain; Region: HELICc; smart00490 452652014627 ATP-binding site [chemical binding]; other site 452652014628 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 452652014629 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 452652014630 cofactor binding site; other site 452652014631 DNA binding site [nucleotide binding] 452652014632 substrate interaction site [chemical binding]; other site 452652014633 Restriction endonuclease NaeI; Region: NaeI; pfam09126 452652014634 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 452652014635 additional DNA contacts [nucleotide binding]; other site 452652014636 mismatch recognition site; other site 452652014637 active site 452652014638 zinc binding site [ion binding]; other site 452652014639 DNA intercalation site [nucleotide binding]; other site 452652014640 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 452652014641 Phosphoesterase family; Region: Phosphoesterase; pfam04185 452652014642 Domain of unknown function (DUF756); Region: DUF756; pfam05506 452652014643 Domain of unknown function (DUF756); Region: DUF756; pfam05506 452652014644 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652014645 salt bridge; other site 452652014646 non-specific DNA binding site [nucleotide binding]; other site 452652014647 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 452652014648 sequence-specific DNA binding site [nucleotide binding]; other site 452652014649 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 452652014650 substrate binding site [chemical binding]; other site 452652014651 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652014652 short chain dehydrogenase; Provisional; Region: PRK07041 452652014653 NAD(P) binding site [chemical binding]; other site 452652014654 active site 452652014655 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652014656 enterobactin exporter EntS; Provisional; Region: PRK10489 452652014657 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 452652014658 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652014659 S-adenosylmethionine binding site [chemical binding]; other site 452652014660 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 452652014661 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 452652014662 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 452652014663 active site 452652014664 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652014665 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652014666 active site 452652014667 phosphorylation site [posttranslational modification] 452652014668 intermolecular recognition site; other site 452652014669 dimerization interface [polypeptide binding]; other site 452652014670 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652014671 DNA binding residues [nucleotide binding] 452652014672 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 452652014673 Histidine kinase; Region: HisKA_3; pfam07730 452652014674 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 452652014675 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452652014676 acyl-activating enzyme (AAE) consensus motif; other site 452652014677 AMP binding site [chemical binding]; other site 452652014678 active site 452652014679 CoA binding site [chemical binding]; other site 452652014680 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 452652014681 active site 452652014682 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 452652014683 TIGR03086 family protein; Region: TIGR03086 452652014684 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 452652014685 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 452652014686 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652014687 putative substrate translocation pore; other site 452652014688 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 452652014689 Cytochrome P450; Region: p450; cl12078 452652014690 Condensation domain; Region: Condensation; pfam00668 452652014691 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 452652014692 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 452652014693 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 452652014694 acyl-activating enzyme (AAE) consensus motif; other site 452652014695 AMP binding site [chemical binding]; other site 452652014696 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 452652014697 Condensation domain; Region: Condensation; pfam00668 452652014698 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 452652014699 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 452652014700 acyl-activating enzyme (AAE) consensus motif; other site 452652014701 AMP binding site [chemical binding]; other site 452652014702 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 452652014703 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 452652014704 Condensation domain; Region: Condensation; pfam00668 452652014705 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 452652014706 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 452652014707 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 452652014708 acyl-activating enzyme (AAE) consensus motif; other site 452652014709 AMP binding site [chemical binding]; other site 452652014710 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 452652014711 Condensation domain; Region: Condensation; pfam00668 452652014712 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 452652014713 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 452652014714 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 452652014715 acyl-activating enzyme (AAE) consensus motif; other site 452652014716 AMP binding site [chemical binding]; other site 452652014717 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 452652014718 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 452652014719 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 452652014720 acyl-activating enzyme (AAE) consensus motif; other site 452652014721 AMP binding site [chemical binding]; other site 452652014722 Condensation domain; Region: Condensation; pfam00668 452652014723 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 452652014724 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 452652014725 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 452652014726 acyl-activating enzyme (AAE) consensus motif; other site 452652014727 AMP binding site [chemical binding]; other site 452652014728 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 452652014729 MbtH-like protein; Region: MbtH; cl01279 452652014730 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 452652014731 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 452652014732 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 452652014733 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 452652014734 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 452652014735 GAF domain; Region: GAF; pfam01590 452652014736 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 452652014737 DDE superfamily endonuclease; Region: DDE_5; cl17874 452652014738 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 452652014739 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 452652014740 Tetramer interface [polypeptide binding]; other site 452652014741 active site 452652014742 FMN-binding site [chemical binding]; other site 452652014743 salicylate hydroxylase; Provisional; Region: PRK08163 452652014744 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 452652014745 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 452652014746 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 452652014747 Glutamine amidotransferase class-I; Region: GATase; pfam00117 452652014748 glutamine binding [chemical binding]; other site 452652014749 catalytic triad [active] 452652014750 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 452652014751 hydrophobic substrate binding pocket; other site 452652014752 Isochorismatase family; Region: Isochorismatase; pfam00857 452652014753 active site 452652014754 conserved cis-peptide bond; other site 452652014755 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 452652014756 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652014757 NAD(P) binding site [chemical binding]; other site 452652014758 active site 452652014759 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 452652014760 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452652014761 active site 452652014762 AMP binding site [chemical binding]; other site 452652014763 acyl-activating enzyme (AAE) consensus motif; other site 452652014764 CoA binding site [chemical binding]; other site 452652014765 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 452652014766 NAD(P) binding site [chemical binding]; other site 452652014767 catalytic residues [active] 452652014768 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 452652014769 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 452652014770 active site 452652014771 catalytic tetrad [active] 452652014772 Cupin domain; Region: Cupin_2; pfam07883 452652014773 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 452652014774 FAD binding domain; Region: FAD_binding_4; pfam01565 452652014775 Berberine and berberine like; Region: BBE; pfam08031 452652014776 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 452652014777 dimerization interface [polypeptide binding]; other site 452652014778 putative DNA binding site [nucleotide binding]; other site 452652014779 putative Zn2+ binding site [ion binding]; other site 452652014780 hypothetical protein; Provisional; Region: PRK08244 452652014781 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 452652014782 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652014783 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652014784 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 452652014785 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652014786 putative substrate translocation pore; other site 452652014787 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 452652014788 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 452652014789 active site 452652014790 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 452652014791 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 452652014792 active site 452652014793 nucleotide binding site [chemical binding]; other site 452652014794 HIGH motif; other site 452652014795 KMSKS motif; other site 452652014796 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 452652014797 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652014798 non-specific DNA binding site [nucleotide binding]; other site 452652014799 salt bridge; other site 452652014800 sequence-specific DNA binding site [nucleotide binding]; other site 452652014801 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 452652014802 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 452652014803 putative metal binding site [ion binding]; other site 452652014804 Putative amidase domain; Region: Amidase_6; pfam12671 452652014805 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 452652014806 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 452652014807 DNA binding site [nucleotide binding] 452652014808 active site 452652014809 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 452652014810 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652014811 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452652014812 DNA binding residues [nucleotide binding] 452652014813 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 452652014814 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 452652014815 DNA binding site [nucleotide binding] 452652014816 active site 452652014817 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 452652014818 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 452652014819 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 452652014820 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 452652014821 short chain dehydrogenase; Provisional; Region: PRK06523 452652014822 classical (c) SDRs; Region: SDR_c; cd05233 452652014823 NAD(P) binding site [chemical binding]; other site 452652014824 active site 452652014825 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 452652014826 active site 452652014827 DNA binding site [nucleotide binding] 452652014828 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 452652014829 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 452652014830 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652014831 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452652014832 DNA binding residues [nucleotide binding] 452652014833 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652014834 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652014835 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 452652014836 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 452652014837 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 452652014838 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 452652014839 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 452652014840 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 452652014841 Zn binding site [ion binding]; other site 452652014842 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 452652014843 Predicted flavoprotein [General function prediction only]; Region: COG0431 452652014844 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 452652014845 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 452652014846 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 452652014847 Predicted flavoprotein [General function prediction only]; Region: COG0431 452652014848 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 452652014849 Domain of unknown function (DUF397); Region: DUF397; pfam04149 452652014850 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652014851 non-specific DNA binding site [nucleotide binding]; other site 452652014852 salt bridge; other site 452652014853 sequence-specific DNA binding site [nucleotide binding]; other site 452652014854 methyltransferase, FxLD system; Region: methyltran_FxLD; TIGR04364 452652014855 Methyltransferase domain; Region: Methyltransf_18; pfam12847 452652014856 FxLD family lantipeptide; Region: LD_lanti_pre; TIGR04363 452652014857 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 452652014858 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 452652014859 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 452652014860 active site 452652014861 zinc binding site [ion binding]; other site 452652014862 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 452652014863 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 452652014864 N-acetyltransferase; Region: Acetyltransf_2; cl00949 452652014865 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 452652014866 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 452652014867 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 452652014868 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 452652014869 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452652014870 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452652014871 acyl-activating enzyme (AAE) consensus motif; other site 452652014872 acyl-activating enzyme (AAE) consensus motif; other site 452652014873 AMP binding site [chemical binding]; other site 452652014874 active site 452652014875 CoA binding site [chemical binding]; other site 452652014876 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652014877 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 452652014878 putative substrate translocation pore; other site 452652014879 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 452652014880 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652014881 non-specific DNA binding site [nucleotide binding]; other site 452652014882 salt bridge; other site 452652014883 sequence-specific DNA binding site [nucleotide binding]; other site 452652014884 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 452652014885 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 452652014886 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 452652014887 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 452652014888 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 452652014889 [4Fe-4S] binding site [ion binding]; other site 452652014890 molybdopterin cofactor binding site; other site 452652014891 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 452652014892 molybdopterin cofactor binding site; other site 452652014893 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 452652014894 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652014895 putative substrate translocation pore; other site 452652014896 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 452652014897 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452652014898 AMP-binding enzyme; Region: AMP-binding; pfam00501 452652014899 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452652014900 active site 452652014901 CoA binding site [chemical binding]; other site 452652014902 AMP binding site [chemical binding]; other site 452652014903 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 452652014904 hydrophobic ligand binding site; other site 452652014905 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 452652014906 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 452652014907 NAD(P) binding site [chemical binding]; other site 452652014908 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 452652014909 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 452652014910 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652014911 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316 452652014912 NAD(P) binding site [chemical binding]; other site 452652014913 active site 452652014914 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 452652014915 Isochorismatase family; Region: Isochorismatase; pfam00857 452652014916 catalytic triad [active] 452652014917 conserved cis-peptide bond; other site 452652014918 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 452652014919 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 452652014920 Glutamine amidotransferase class-I; Region: GATase; pfam00117 452652014921 glutamine binding [chemical binding]; other site 452652014922 catalytic triad [active] 452652014923 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 452652014924 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 452652014925 dimer interface [polypeptide binding]; other site 452652014926 active site 452652014927 CoA binding pocket [chemical binding]; other site 452652014928 N-acetyltransferase; Region: Acetyltransf_2; cl00949 452652014929 hypothetical protein; Provisional; Region: PRK06184 452652014930 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 452652014931 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 452652014932 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 452652014933 NB-ARC domain; Region: NB-ARC; pfam00931 452652014934 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452652014935 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452652014936 binding surface 452652014937 TPR motif; other site 452652014938 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452652014939 DDE superfamily endonuclease; Region: DDE_5; cl17874 452652014940 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 452652014941 FOG: WD40 repeat [General function prediction only]; Region: COG2319 452652014942 structural tetrad; other site 452652014943 FOG: WD40 repeat [General function prediction only]; Region: COG2319 452652014944 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 452652014945 structural tetrad; other site 452652014946 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 452652014947 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 452652014948 dimerization interface [polypeptide binding]; other site 452652014949 active site 452652014950 Uncharacterized conserved protein [Function unknown]; Region: COG1262 452652014951 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 452652014952 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 452652014953 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 452652014954 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 452652014955 catalytic residue [active] 452652014956 Methyltransferase domain; Region: Methyltransf_23; pfam13489 452652014957 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652014958 S-adenosylmethionine binding site [chemical binding]; other site 452652014959 2-oxoglutarate-dependent dioxygenase; Region: PLN02365 452652014960 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 452652014961 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 452652014962 serine O-acetyltransferase; Region: cysE; TIGR01172 452652014963 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 452652014964 trimer interface [polypeptide binding]; other site 452652014965 active site 452652014966 substrate binding site [chemical binding]; other site 452652014967 CoA binding site [chemical binding]; other site 452652014968 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 452652014969 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 452652014970 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 452652014971 TPP-binding site [chemical binding]; other site 452652014972 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 452652014973 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 452652014974 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 452652014975 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 452652014976 radical SAM/SPASM domain protein, GRRM system; Region: rSAM_GlyRichRpt; TIGR04261 452652014977 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 452652014978 FeS/SAM binding site; other site 452652014979 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 452652014980 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 452652014981 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 452652014982 active site 452652014983 PHP Thumb interface [polypeptide binding]; other site 452652014984 metal binding site [ion binding]; metal-binding site 452652014985 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 452652014986 generic binding surface II; other site 452652014987 generic binding surface I; other site 452652014988 Chitin binding domain; Region: Chitin_bind_3; pfam03067 452652014989 CBD_II domain; Region: CBD_II; smart00637 452652014990 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 452652014991 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 452652014992 homodimer interface [polypeptide binding]; other site 452652014993 active site 452652014994 TDP-binding site; other site 452652014995 acceptor substrate-binding pocket; other site 452652014996 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 452652014997 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 452652014998 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 452652014999 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 452652015000 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 452652015001 active site 452652015002 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 452652015003 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 452652015004 NAD(P) binding site [chemical binding]; other site 452652015005 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 452652015006 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 452652015007 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 452652015008 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 452652015009 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 452652015010 hydrophobic ligand binding site; other site 452652015011 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 452652015012 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 452652015013 catalytic residue [active] 452652015014 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 452652015015 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 452652015016 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 452652015017 dimer interface [polypeptide binding]; other site 452652015018 active site 452652015019 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 452652015020 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652015021 NAD(P) binding site [chemical binding]; other site 452652015022 active site 452652015023 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 452652015024 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652015025 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652015026 active site 452652015027 phosphorylation site [posttranslational modification] 452652015028 intermolecular recognition site; other site 452652015029 dimerization interface [polypeptide binding]; other site 452652015030 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652015031 DNA binding residues [nucleotide binding] 452652015032 dimerization interface [polypeptide binding]; other site 452652015033 Histidine kinase; Region: HisKA_3; pfam07730 452652015034 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 452652015035 Mg2+ binding site [ion binding]; other site 452652015036 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 452652015037 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652015038 Walker A/P-loop; other site 452652015039 ATP binding site [chemical binding]; other site 452652015040 Q-loop/lid; other site 452652015041 ABC transporter signature motif; other site 452652015042 Walker B; other site 452652015043 D-loop; other site 452652015044 H-loop/switch region; other site 452652015045 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 452652015046 Transcriptional regulators [Transcription]; Region: PurR; COG1609 452652015047 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 452652015048 DNA binding site [nucleotide binding] 452652015049 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 452652015050 putative dimerization interface [polypeptide binding]; other site 452652015051 putative ligand binding site [chemical binding]; other site 452652015052 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 452652015053 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 452652015054 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652015055 dimer interface [polypeptide binding]; other site 452652015056 conserved gate region; other site 452652015057 putative PBP binding loops; other site 452652015058 ABC-ATPase subunit interface; other site 452652015059 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 452652015060 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652015061 dimer interface [polypeptide binding]; other site 452652015062 conserved gate region; other site 452652015063 putative PBP binding loops; other site 452652015064 ABC-ATPase subunit interface; other site 452652015065 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 452652015066 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 452652015067 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 452652015068 Uncharacterized conserved protein [Function unknown]; Region: COG3391 452652015069 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 452652015070 Phosphoesterase family; Region: Phosphoesterase; pfam04185 452652015071 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 452652015072 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 452652015073 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652015074 Walker A/P-loop; other site 452652015075 ATP binding site [chemical binding]; other site 452652015076 Q-loop/lid; other site 452652015077 ABC transporter signature motif; other site 452652015078 Walker B; other site 452652015079 D-loop; other site 452652015080 H-loop/switch region; other site 452652015081 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652015082 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652015083 DNA binding residues [nucleotide binding] 452652015084 dimerization interface [polypeptide binding]; other site 452652015085 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 452652015086 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 452652015087 Histidine kinase; Region: HisKA_3; pfam07730 452652015088 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 452652015089 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652015090 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652015091 active site 452652015092 phosphorylation site [posttranslational modification] 452652015093 intermolecular recognition site; other site 452652015094 dimerization interface [polypeptide binding]; other site 452652015095 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652015096 DNA binding residues [nucleotide binding] 452652015097 dimerization interface [polypeptide binding]; other site 452652015098 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 452652015099 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 452652015100 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 452652015101 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 452652015102 ligand binding site [chemical binding]; other site 452652015103 homodimer interface [polypeptide binding]; other site 452652015104 NAD(P) binding site [chemical binding]; other site 452652015105 trimer interface B [polypeptide binding]; other site 452652015106 trimer interface A [polypeptide binding]; other site 452652015107 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 452652015108 DDE superfamily endonuclease; Region: DDE_5; pfam13546 452652015109 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 452652015110 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 452652015111 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 452652015112 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 452652015113 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 452652015114 AsnC family; Region: AsnC_trans_reg; pfam01037 452652015115 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652015116 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 452652015117 NAD(P) binding site [chemical binding]; other site 452652015118 active site 452652015119 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 452652015120 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 452652015121 DNA-binding site [nucleotide binding]; DNA binding site 452652015122 RNA-binding motif; other site 452652015123 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 452652015124 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 452652015125 RNA/DNA hybrid binding site [nucleotide binding]; other site 452652015126 active site 452652015127 heat shock protein 90; Provisional; Region: PRK05218 452652015128 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652015129 ATP binding site [chemical binding]; other site 452652015130 Mg2+ binding site [ion binding]; other site 452652015131 G-X-G motif; other site 452652015132 Transglycosylase; Region: Transgly; pfam00912 452652015133 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 452652015134 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 452652015135 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 452652015136 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 452652015137 active site 452652015138 putative catalytic site [active] 452652015139 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 452652015140 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 452652015141 salt bridge; other site 452652015142 non-specific DNA binding site [nucleotide binding]; other site 452652015143 sequence-specific DNA binding site [nucleotide binding]; other site 452652015144 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 452652015145 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 452652015146 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 452652015147 active site 452652015148 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 452652015149 aromatic chitin/cellulose binding site residues [chemical binding]; other site 452652015150 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 452652015151 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652015152 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 452652015153 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 452652015154 active site 452652015155 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 452652015156 CoenzymeA binding site [chemical binding]; other site 452652015157 subunit interaction site [polypeptide binding]; other site 452652015158 PHB binding site; other site 452652015159 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 452652015160 Transcriptional regulators [Transcription]; Region: MarR; COG1846 452652015161 MarR family; Region: MarR; pfam01047 452652015162 DoxX-like family; Region: DoxX_2; pfam13564 452652015163 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 452652015164 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 452652015165 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 452652015166 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 452652015167 Transcriptional regulator [Transcription]; Region: LysR; COG0583 452652015168 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 452652015169 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 452652015170 dimerization interface [polypeptide binding]; other site 452652015171 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 452652015172 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 452652015173 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 452652015174 FeS/SAM binding site; other site 452652015175 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452652015176 Coenzyme A binding pocket [chemical binding]; other site 452652015177 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652015178 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652015179 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 452652015180 Leucine carboxyl methyltransferase; Region: LCM; cl01306 452652015181 Isochorismatase family; Region: Isochorismatase; pfam00857 452652015182 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 452652015183 catalytic triad [active] 452652015184 conserved cis-peptide bond; other site 452652015185 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 452652015186 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 452652015187 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 452652015188 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 452652015189 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 452652015190 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652015191 non-specific DNA binding site [nucleotide binding]; other site 452652015192 salt bridge; other site 452652015193 sequence-specific DNA binding site [nucleotide binding]; other site 452652015194 Cupin domain; Region: Cupin_2; pfam07883 452652015195 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 452652015196 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 452652015197 inhibitor site; inhibition site 452652015198 active site 452652015199 dimer interface [polypeptide binding]; other site 452652015200 catalytic residue [active] 452652015201 class II aldolase/adducin domain protein; Provisional; Region: PRK07090 452652015202 intersubunit interface [polypeptide binding]; other site 452652015203 active site 452652015204 Zn2+ binding site [ion binding]; other site 452652015205 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 452652015206 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 452652015207 Domain of unknown function (DUF397); Region: DUF397; pfam04149 452652015208 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 452652015209 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 452652015210 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 452652015211 MarR family; Region: MarR; pfam01047 452652015212 Domain of unknown function (DUF397); Region: DUF397; pfam04149 452652015213 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652015214 non-specific DNA binding site [nucleotide binding]; other site 452652015215 salt bridge; other site 452652015216 sequence-specific DNA binding site [nucleotide binding]; other site 452652015217 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 452652015218 ATP binding site [chemical binding]; other site 452652015219 putative Mg++ binding site [ion binding]; other site 452652015220 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 452652015221 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 452652015222 nucleotide binding region [chemical binding]; other site 452652015223 ATP-binding site [chemical binding]; other site 452652015224 Prostaglandin dehydrogenases; Region: PGDH; cd05288 452652015225 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 452652015226 NAD(P) binding site [chemical binding]; other site 452652015227 substrate binding site [chemical binding]; other site 452652015228 dimer interface [polypeptide binding]; other site 452652015229 Transcriptional regulator [Transcription]; Region: LysR; COG0583 452652015230 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 452652015231 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 452652015232 dimerization interface [polypeptide binding]; other site 452652015233 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 452652015234 FOG: WD40 repeat [General function prediction only]; Region: COG2319 452652015235 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 452652015236 structural tetrad; other site 452652015237 Domain of unknown function (DUF4200); Region: DUF4200; pfam13863 452652015238 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 452652015239 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 452652015240 AAA ATPase domain; Region: AAA_16; pfam13191 452652015241 NB-ARC domain; Region: NB-ARC; pfam00931 452652015242 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 452652015243 CoenzymeA binding site [chemical binding]; other site 452652015244 subunit interaction site [polypeptide binding]; other site 452652015245 PHB binding site; other site 452652015246 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 452652015247 [4Fe-4S] binding site [ion binding]; other site 452652015248 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 452652015249 molybdopterin cofactor binding site; other site 452652015250 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 452652015251 molybdopterin cofactor binding site; other site 452652015252 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 452652015253 Flavodoxin; Region: Flavodoxin_1; pfam00258 452652015254 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 452652015255 FAD binding pocket [chemical binding]; other site 452652015256 FAD binding motif [chemical binding]; other site 452652015257 catalytic residues [active] 452652015258 NAD binding pocket [chemical binding]; other site 452652015259 phosphate binding motif [ion binding]; other site 452652015260 beta-alpha-beta structure motif; other site 452652015261 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452652015262 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 452652015263 acyl-activating enzyme (AAE) consensus motif; other site 452652015264 AMP binding site [chemical binding]; other site 452652015265 active site 452652015266 CoA binding site [chemical binding]; other site 452652015267 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652015268 NAD(P) binding site [chemical binding]; other site 452652015269 active site 452652015270 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652015271 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452652015272 acyl-activating enzyme (AAE) consensus motif; other site 452652015273 active site 452652015274 AMP binding site [chemical binding]; other site 452652015275 CoA binding site [chemical binding]; other site 452652015276 ATP-grasp domain; Region: ATP-grasp_4; cl17255 452652015277 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 452652015278 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452652015279 AMP-binding enzyme; Region: AMP-binding; pfam00501 452652015280 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452652015281 acyl-activating enzyme (AAE) consensus motif; other site 452652015282 acyl-activating enzyme (AAE) consensus motif; other site 452652015283 AMP binding site [chemical binding]; other site 452652015284 active site 452652015285 CoA binding site [chemical binding]; other site 452652015286 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 452652015287 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 452652015288 hydroxyglutarate oxidase; Provisional; Region: PRK11728 452652015289 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 452652015290 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452652015291 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 452652015292 acyl-activating enzyme (AAE) consensus motif; other site 452652015293 AMP binding site [chemical binding]; other site 452652015294 active site 452652015295 CoA binding site [chemical binding]; other site 452652015296 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 452652015297 PBP superfamily domain; Region: PBP_like_2; pfam12849 452652015298 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 452652015299 nudix motif; other site 452652015300 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 452652015301 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652015302 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 452652015303 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 452652015304 Catalytic domain of Protein Kinases; Region: PKc; cd00180 452652015305 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 452652015306 active site 452652015307 ATP binding site [chemical binding]; other site 452652015308 substrate binding site [chemical binding]; other site 452652015309 activation loop (A-loop); other site 452652015310 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452652015311 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 452652015312 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652015313 Domain of unknown function (DUF3893); Region: DUF3893; pfam13032 452652015314 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652015315 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652015316 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 452652015317 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 452652015318 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 452652015319 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 452652015320 active site 452652015321 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 452652015322 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 452652015323 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 452652015324 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 452652015325 active site 452652015326 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 452652015327 dimerization interface [polypeptide binding]; other site 452652015328 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 452652015329 phosphoglucomutase; Validated; Region: PRK07564 452652015330 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 452652015331 active site 452652015332 substrate binding site [chemical binding]; other site 452652015333 metal binding site [ion binding]; metal-binding site 452652015334 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 452652015335 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 452652015336 nucleotide binding site/active site [active] 452652015337 HIT family signature motif; other site 452652015338 catalytic residue [active] 452652015339 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 452652015340 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 452652015341 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 452652015342 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 452652015343 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 452652015344 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 452652015345 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 452652015346 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 452652015347 ATP binding site [chemical binding]; other site 452652015348 Mg2+ binding site [ion binding]; other site 452652015349 G-X-G motif; other site 452652015350 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652015351 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652015352 active site 452652015353 phosphorylation site [posttranslational modification] 452652015354 intermolecular recognition site; other site 452652015355 dimerization interface [polypeptide binding]; other site 452652015356 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652015357 DNA binding residues [nucleotide binding] 452652015358 dimerization interface [polypeptide binding]; other site 452652015359 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 452652015360 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 452652015361 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 452652015362 Helix-turn-helix domain; Region: HTH_18; pfam12833 452652015363 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452652015364 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cd00421 452652015365 active site 452652015366 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 452652015367 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 452652015368 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137 452652015369 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 452652015370 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 452652015371 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 452652015372 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 452652015373 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 452652015374 catalytic residue [active] 452652015375 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 452652015376 NlpC/P60 family; Region: NLPC_P60; pfam00877 452652015377 Penicillinase repressor; Region: Pencillinase_R; pfam03965 452652015378 Peptidase family M48; Region: Peptidase_M48; cl12018 452652015379 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 452652015380 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 452652015381 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 452652015382 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 452652015383 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 452652015384 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652015385 S-adenosylmethionine binding site [chemical binding]; other site 452652015386 Predicted membrane protein [Function unknown]; Region: COG2323 452652015387 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 452652015388 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452652015389 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 452652015390 acyl-activating enzyme (AAE) consensus motif; other site 452652015391 AMP binding site [chemical binding]; other site 452652015392 active site 452652015393 CoA binding site [chemical binding]; other site 452652015394 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 452652015395 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 452652015396 putative trimer interface [polypeptide binding]; other site 452652015397 putative CoA binding site [chemical binding]; other site 452652015398 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 452652015399 putative trimer interface [polypeptide binding]; other site 452652015400 putative CoA binding site [chemical binding]; other site 452652015401 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 452652015402 Zn binding site [ion binding]; other site 452652015403 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 452652015404 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 452652015405 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 452652015406 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 452652015407 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 452652015408 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 452652015409 PRC-barrel domain; Region: PRC; pfam05239 452652015410 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 452652015411 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 452652015412 Clp amino terminal domain; Region: Clp_N; pfam02861 452652015413 Clp amino terminal domain; Region: Clp_N; pfam02861 452652015414 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452652015415 Walker A motif; other site 452652015416 ATP binding site [chemical binding]; other site 452652015417 Walker B motif; other site 452652015418 arginine finger; other site 452652015419 UvrB/uvrC motif; Region: UVR; pfam02151 452652015420 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452652015421 Walker A motif; other site 452652015422 ATP binding site [chemical binding]; other site 452652015423 Walker B motif; other site 452652015424 arginine finger; other site 452652015425 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 452652015426 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 452652015427 putative active site [active] 452652015428 putative metal binding site [ion binding]; other site 452652015429 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 452652015430 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 452652015431 hypothetical protein; Provisional; Region: PRK01842 452652015432 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 452652015433 RNA binding surface [nucleotide binding]; other site 452652015434 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 452652015435 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 452652015436 active site 452652015437 FMN binding site [chemical binding]; other site 452652015438 2,4-decadienoyl-CoA binding site; other site 452652015439 catalytic residue [active] 452652015440 4Fe-4S cluster binding site [ion binding]; other site 452652015441 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 452652015442 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 452652015443 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 452652015444 Predicted transcriptional regulators [Transcription]; Region: COG1695 452652015445 Transcriptional regulator PadR-like family; Region: PadR; cl17335 452652015446 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 452652015447 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 452652015448 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 452652015449 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 452652015450 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 452652015451 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 452652015452 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 452652015453 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452652015454 Coenzyme A binding pocket [chemical binding]; other site 452652015455 Uncharacterized conserved protein [Function unknown]; Region: COG3342 452652015456 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 452652015457 Putative peptidoglycan binding domain; Region: PG_binding_2; pfam08823 452652015458 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 452652015459 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 452652015460 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 452652015461 catalytic residue [active] 452652015462 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 452652015463 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 452652015464 putative DNA binding site [nucleotide binding]; other site 452652015465 putative Zn2+ binding site [ion binding]; other site 452652015466 AsnC family; Region: AsnC_trans_reg; pfam01037 452652015467 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 452652015468 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652015469 ATP binding site [chemical binding]; other site 452652015470 Mg2+ binding site [ion binding]; other site 452652015471 G-X-G motif; other site 452652015472 Transcriptional regulators [Transcription]; Region: PurR; COG1609 452652015473 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 452652015474 DNA binding site [nucleotide binding] 452652015475 domain linker motif; other site 452652015476 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 452652015477 dimerization interface [polypeptide binding]; other site 452652015478 ligand binding site [chemical binding]; other site 452652015479 Helix-turn-helix domain; Region: HTH_18; pfam12833 452652015480 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452652015481 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 452652015482 Catalytic domain of Protein Kinases; Region: PKc; cd00180 452652015483 active site 452652015484 ATP binding site [chemical binding]; other site 452652015485 substrate binding site [chemical binding]; other site 452652015486 activation loop (A-loop); other site 452652015487 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 452652015488 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652015489 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452652015490 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652015491 Major Facilitator Superfamily; Region: MFS_1; pfam07690 452652015492 putative substrate translocation pore; other site 452652015493 Uncharacterized conserved protein [Function unknown]; Region: COG1434 452652015494 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 452652015495 putative active site [active] 452652015496 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 452652015497 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 452652015498 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 452652015499 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 452652015500 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 452652015501 putative substrate binding site [chemical binding]; other site 452652015502 putative ATP binding site [chemical binding]; other site 452652015503 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 452652015504 nudix motif; other site 452652015505 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 452652015506 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 452652015507 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 452652015508 DNA-binding site [nucleotide binding]; DNA binding site 452652015509 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 452652015510 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652015511 homodimer interface [polypeptide binding]; other site 452652015512 catalytic residue [active] 452652015513 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 452652015514 H+ Antiporter protein; Region: 2A0121; TIGR00900 452652015515 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 452652015516 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 452652015517 putative ligand binding site [chemical binding]; other site 452652015518 EamA-like transporter family; Region: EamA; pfam00892 452652015519 Lipase maturation factor; Region: LMF1; pfam06762 452652015520 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 452652015521 nucleoside/Zn binding site; other site 452652015522 dimer interface [polypeptide binding]; other site 452652015523 catalytic motif [active] 452652015524 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 452652015525 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 452652015526 Cytochrome P450; Region: p450; cl12078 452652015527 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452652015528 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452652015529 binding surface 452652015530 TPR motif; other site 452652015531 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452652015532 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 452652015533 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 452652015534 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 452652015535 putative DNA binding site [nucleotide binding]; other site 452652015536 putative Zn2+ binding site [ion binding]; other site 452652015537 AsnC family; Region: AsnC_trans_reg; pfam01037 452652015538 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 452652015539 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 452652015540 Secretory lipase; Region: LIP; pfam03583 452652015541 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 452652015542 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 452652015543 TrkA-N domain; Region: TrkA_N; pfam02254 452652015544 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 452652015545 TrkA-N domain; Region: TrkA_N; pfam02254 452652015546 TrkA-C domain; Region: TrkA_C; pfam02080 452652015547 enoyl-CoA hydratase; Provisional; Region: PRK05862 452652015548 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 452652015549 substrate binding site [chemical binding]; other site 452652015550 oxyanion hole (OAH) forming residues; other site 452652015551 trimer interface [polypeptide binding]; other site 452652015552 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 452652015553 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 452652015554 substrate binding site [chemical binding]; other site 452652015555 oxyanion hole (OAH) forming residues; other site 452652015556 trimer interface [polypeptide binding]; other site 452652015557 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 452652015558 fumarylacetoacetase; Region: PLN02856 452652015559 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 452652015560 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 452652015561 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 452652015562 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 452652015563 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 452652015564 dimer interface [polypeptide binding]; other site 452652015565 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 452652015566 active site 452652015567 Fe binding site [ion binding]; other site 452652015568 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 452652015569 SPW repeat; Region: SPW; pfam03779 452652015570 fumarate hydratase; Reviewed; Region: fumC; PRK00485 452652015571 aspartase (L-aspartate ammonia-lyase) and fumarase class II enzymes; Region: Aspartase_like; cd01596 452652015572 active sites [active] 452652015573 tetramer interface [polypeptide binding]; other site 452652015574 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 452652015575 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 452652015576 active site 452652015577 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 452652015578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652015579 putative substrate translocation pore; other site 452652015580 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 452652015581 active site 452652015582 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 452652015583 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 452652015584 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 452652015585 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 452652015586 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652015587 conserved gate region; other site 452652015588 ABC-ATPase subunit interface; other site 452652015589 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 452652015590 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652015591 Walker A/P-loop; other site 452652015592 ATP binding site [chemical binding]; other site 452652015593 Q-loop/lid; other site 452652015594 ABC transporter signature motif; other site 452652015595 Walker B; other site 452652015596 D-loop; other site 452652015597 H-loop/switch region; other site 452652015598 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 452652015599 active site residue [active] 452652015600 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 452652015601 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452652015602 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452652015603 dimer interface [polypeptide binding]; other site 452652015604 phosphorylation site [posttranslational modification] 452652015605 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652015606 ATP binding site [chemical binding]; other site 452652015607 Mg2+ binding site [ion binding]; other site 452652015608 G-X-G motif; other site 452652015609 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 452652015610 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652015611 active site 452652015612 phosphorylation site [posttranslational modification] 452652015613 intermolecular recognition site; other site 452652015614 dimerization interface [polypeptide binding]; other site 452652015615 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 452652015616 DNA binding site [nucleotide binding] 452652015617 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 452652015618 active site 452652015619 metal binding site [ion binding]; metal-binding site 452652015620 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 452652015621 MarR family; Region: MarR; pfam01047 452652015622 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 452652015623 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652015624 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452652015625 DNA binding residues [nucleotide binding] 452652015626 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 452652015627 substrate binding pocket [chemical binding]; other site 452652015628 substrate-Mg2+ binding site; other site 452652015629 aspartate-rich region 1; other site 452652015630 aspartate-rich region 2; other site 452652015631 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 452652015632 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 452652015633 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 452652015634 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 452652015635 metal binding site [ion binding]; metal-binding site 452652015636 dimer interface [polypeptide binding]; other site 452652015637 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 452652015638 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 452652015639 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 452652015640 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 452652015641 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 452652015642 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 452652015643 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 452652015644 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 452652015645 FAD binding pocket [chemical binding]; other site 452652015646 FAD binding motif [chemical binding]; other site 452652015647 phosphate binding motif [ion binding]; other site 452652015648 beta-alpha-beta structure motif; other site 452652015649 NAD(p) ribose binding residues [chemical binding]; other site 452652015650 NAD binding pocket [chemical binding]; other site 452652015651 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 452652015652 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 452652015653 catalytic loop [active] 452652015654 iron binding site [ion binding]; other site 452652015655 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 452652015656 Predicted transcriptional regulator [Transcription]; Region: COG2378 452652015657 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 452652015658 putative DNA binding site [nucleotide binding]; other site 452652015659 putative Zn2+ binding site [ion binding]; other site 452652015660 WYL domain; Region: WYL; pfam13280 452652015661 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 452652015662 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 452652015663 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 452652015664 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 452652015665 metal ion-dependent adhesion site (MIDAS); other site 452652015666 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 452652015667 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 452652015668 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 452652015669 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 452652015670 structural tetrad; other site 452652015671 FOG: WD40 repeat [General function prediction only]; Region: COG2319 452652015672 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 452652015673 structural tetrad; other site 452652015674 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 452652015675 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452652015676 Tetratricopeptide repeat; Region: TPR_10; pfam13374 452652015677 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452652015678 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452652015679 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452652015680 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452652015681 Tetratricopeptide repeat; Region: TPR_10; pfam13374 452652015682 Prokaryotic RING finger family 4; Region: Prok-RING_4; pfam14447 452652015683 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 452652015684 putative metal binding site [ion binding]; other site 452652015685 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 452652015686 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652015687 Walker A/P-loop; other site 452652015688 ATP binding site [chemical binding]; other site 452652015689 Q-loop/lid; other site 452652015690 ABC transporter signature motif; other site 452652015691 Walker B; other site 452652015692 D-loop; other site 452652015693 H-loop/switch region; other site 452652015694 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 452652015695 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652015696 putative PBP binding loops; other site 452652015697 dimer interface [polypeptide binding]; other site 452652015698 ABC-ATPase subunit interface; other site 452652015699 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 452652015700 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 452652015701 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 452652015702 Cytochrome P450; Region: p450; cl12078 452652015703 Protein of unknown function (DUF2004); Region: DUF2004; pfam09406 452652015704 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 452652015705 Nitrate and nitrite sensing; Region: NIT; pfam08376 452652015706 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452652015707 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652015708 ATP binding site [chemical binding]; other site 452652015709 Mg2+ binding site [ion binding]; other site 452652015710 G-X-G motif; other site 452652015711 Roadblock/LC7 domain; Region: Robl_LC7; pfam03259 452652015712 Protein of unknown function (DUF742); Region: DUF742; pfam05331 452652015713 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 452652015714 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 452652015715 G1 box; other site 452652015716 GTP/Mg2+ binding site [chemical binding]; other site 452652015717 G2 box; other site 452652015718 Switch I region; other site 452652015719 G3 box; other site 452652015720 Switch II region; other site 452652015721 G4 box; other site 452652015722 G5 box; other site 452652015723 Major Facilitator Superfamily; Region: MFS_1; pfam07690 452652015724 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 452652015725 Histidine kinase; Region: HisKA_3; pfam07730 452652015726 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 452652015727 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652015728 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652015729 active site 452652015730 phosphorylation site [posttranslational modification] 452652015731 intermolecular recognition site; other site 452652015732 dimerization interface [polypeptide binding]; other site 452652015733 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652015734 DNA binding residues [nucleotide binding] 452652015735 dimerization interface [polypeptide binding]; other site 452652015736 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652015737 S-adenosylmethionine binding site [chemical binding]; other site 452652015738 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 452652015739 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 452652015740 inhibitor-cofactor binding pocket; inhibition site 452652015741 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652015742 catalytic residue [active] 452652015743 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 452652015744 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 452652015745 catalytic residue [active] 452652015746 Phosphoinositide phospholipase C; Region: PLN02228 452652015747 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 452652015748 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 452652015749 active site 452652015750 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 452652015751 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 452652015752 DNA binding residues [nucleotide binding] 452652015753 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 452652015754 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 452652015755 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 452652015756 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 452652015757 short chain dehydrogenase; Provisional; Region: PRK05872 452652015758 classical (c) SDRs; Region: SDR_c; cd05233 452652015759 NAD(P) binding site [chemical binding]; other site 452652015760 active site 452652015761 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 452652015762 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 452652015763 sugar binding site [chemical binding]; other site 452652015764 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 452652015765 classical (c) SDRs; Region: SDR_c; cd05233 452652015766 NAD(P) binding site [chemical binding]; other site 452652015767 active site 452652015768 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 452652015769 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 452652015770 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652015771 Walker A/P-loop; other site 452652015772 ATP binding site [chemical binding]; other site 452652015773 Q-loop/lid; other site 452652015774 ABC transporter signature motif; other site 452652015775 Walker B; other site 452652015776 D-loop; other site 452652015777 H-loop/switch region; other site 452652015778 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 452652015779 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 452652015780 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 452652015781 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 452652015782 putative acyl-acceptor binding pocket; other site 452652015783 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 452652015784 active site 452652015785 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 452652015786 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 452652015787 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 452652015788 poly(3-hydroxyalkanoate) depolymerase; Region: PHA_depoly_arom; TIGR02240 452652015789 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652015790 non-specific DNA binding site [nucleotide binding]; other site 452652015791 salt bridge; other site 452652015792 sequence-specific DNA binding site [nucleotide binding]; other site 452652015793 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 452652015794 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 452652015795 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652015796 Walker A/P-loop; other site 452652015797 ATP binding site [chemical binding]; other site 452652015798 Q-loop/lid; other site 452652015799 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652015800 ABC transporter signature motif; other site 452652015801 Walker B; other site 452652015802 D-loop; other site 452652015803 H-loop/switch region; other site 452652015804 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 452652015805 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 452652015806 active site 452652015807 metal binding site [ion binding]; metal-binding site 452652015808 DNA binding site [nucleotide binding] 452652015809 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 452652015810 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 452652015811 active site 452652015812 catalytic triad [active] 452652015813 oxyanion hole [active] 452652015814 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 452652015815 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 452652015816 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 452652015817 NodB motif; other site 452652015818 active site 452652015819 catalytic site [active] 452652015820 metal binding site [ion binding]; metal-binding site 452652015821 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 452652015822 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 452652015823 acyl-activating enzyme (AAE) consensus motif; other site 452652015824 putative AMP binding site [chemical binding]; other site 452652015825 putative active site [active] 452652015826 putative CoA binding site [chemical binding]; other site 452652015827 Nitrate and nitrite sensing; Region: NIT; pfam08376 452652015828 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452652015829 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652015830 ATP binding site [chemical binding]; other site 452652015831 Mg2+ binding site [ion binding]; other site 452652015832 G-X-G motif; other site 452652015833 Roadblock/LC7 domain; Region: Robl_LC7; pfam03259 452652015834 Protein of unknown function (DUF742); Region: DUF742; pfam05331 452652015835 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 452652015836 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 452652015837 G1 box; other site 452652015838 GTP/Mg2+ binding site [chemical binding]; other site 452652015839 G2 box; other site 452652015840 Switch I region; other site 452652015841 G3 box; other site 452652015842 Switch II region; other site 452652015843 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 452652015844 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 452652015845 DNA binding site [nucleotide binding] 452652015846 Transcriptional regulator [Transcription]; Region: IclR; COG1414 452652015847 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 452652015848 Bacterial transcriptional regulator; Region: IclR; pfam01614 452652015849 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 452652015850 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 452652015851 membrane-bound complex binding site; other site 452652015852 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 452652015853 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 452652015854 substrate binding pocket [chemical binding]; other site 452652015855 membrane-bound complex binding site; other site 452652015856 hinge residues; other site 452652015857 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 452652015858 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 452652015859 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 452652015860 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652015861 Walker A/P-loop; other site 452652015862 ATP binding site [chemical binding]; other site 452652015863 Q-loop/lid; other site 452652015864 ABC transporter signature motif; other site 452652015865 Walker B; other site 452652015866 D-loop; other site 452652015867 H-loop/switch region; other site 452652015868 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 452652015869 substrate binding pocket [chemical binding]; other site 452652015870 membrane-bound complex binding site; other site 452652015871 hinge residues; other site 452652015872 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 452652015873 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 452652015874 active site 452652015875 dimer interface [polypeptide binding]; other site 452652015876 non-prolyl cis peptide bond; other site 452652015877 insertion regions; other site 452652015878 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 452652015879 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 452652015880 active site 452652015881 catalytic tetrad [active] 452652015882 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 452652015883 heme-binding site [chemical binding]; other site 452652015884 H+ Antiporter protein; Region: 2A0121; TIGR00900 452652015885 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652015886 putative substrate translocation pore; other site 452652015887 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 452652015888 active site 452652015889 ATP binding site [chemical binding]; other site 452652015890 substrate binding site [chemical binding]; other site 452652015891 activation loop (A-loop); other site 452652015892 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 452652015893 active site 452652015894 zinc binding site [ion binding]; other site 452652015895 Beta-lactamase; Region: Beta-lactamase; pfam00144 452652015896 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 452652015897 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 452652015898 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 452652015899 MMPL family; Region: MMPL; pfam03176 452652015900 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 452652015901 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 452652015902 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 452652015903 TrkA-C domain; Region: TrkA_C; pfam02080 452652015904 TrkA-C domain; Region: TrkA_C; pfam02080 452652015905 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 452652015906 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 452652015907 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 452652015908 TrkA-C domain; Region: TrkA_C; pfam02080 452652015909 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 452652015910 aspartate aminotransferase; Provisional; Region: PRK09275 452652015911 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 452652015912 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652015913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652015914 active site 452652015915 phosphorylation site [posttranslational modification] 452652015916 intermolecular recognition site; other site 452652015917 dimerization interface [polypeptide binding]; other site 452652015918 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652015919 DNA binding residues [nucleotide binding] 452652015920 dimerization interface [polypeptide binding]; other site 452652015921 Histidine kinase; Region: HisKA_3; pfam07730 452652015922 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 452652015923 PGAP1-like protein; Region: PGAP1; pfam07819 452652015924 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 452652015925 Ligand Binding Site [chemical binding]; other site 452652015926 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 452652015927 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652015928 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 452652015929 classical (c) SDRs; Region: SDR_c; cd05233 452652015930 NAD(P) binding site [chemical binding]; other site 452652015931 active site 452652015932 Putative esterase; Region: Esterase; pfam00756 452652015933 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 452652015934 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 452652015935 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 452652015936 active site 452652015937 barstar interaction site; other site 452652015938 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 452652015939 active site 452652015940 catalytic residues [active] 452652015941 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452652015942 binding surface 452652015943 TPR motif; other site 452652015944 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452652015945 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452652015946 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452652015947 binding surface 452652015948 TPR motif; other site 452652015949 SUKH-4 immunity protein; Region: SUKH-4; pfam14435 452652015950 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 452652015951 Transcriptional regulator [Transcription]; Region: IclR; COG1414 452652015952 Bacterial transcriptional regulator; Region: IclR; pfam01614 452652015953 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 452652015954 malate synthase A; Region: malate_syn_A; TIGR01344 452652015955 active site 452652015956 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 452652015957 putative active site pocket [active] 452652015958 TROVE domain; Region: TROVE; pfam05731 452652015959 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 452652015960 metal ion-dependent adhesion site (MIDAS); other site 452652015961 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 452652015962 putative DNA binding site [nucleotide binding]; other site 452652015963 putative Zn2+ binding site [ion binding]; other site 452652015964 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652015965 Major Facilitator Superfamily; Region: MFS_1; pfam07690 452652015966 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 452652015967 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 452652015968 active site 452652015969 putative substrate binding pocket [chemical binding]; other site 452652015970 xanthine permease; Region: pbuX; TIGR03173 452652015971 urate oxidase; Region: urate_oxi; TIGR03383 452652015972 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 452652015973 active site 452652015974 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 452652015975 active site 452652015976 homotetramer interface [polypeptide binding]; other site 452652015977 putative OHCU decarboxylase; Provisional; Region: PRK13798 452652015978 HTH domain; Region: HTH_22; pfam13309 452652015979 Domain of unknown function DUF77; Region: DUF77; pfam01910 452652015980 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 452652015981 2-hydroxy-3-oxopropionate reductase; Region: tartro_sem_red; TIGR01505 452652015982 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 452652015983 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 452652015984 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 452652015985 allantoinase; Region: allantoinase; TIGR03178 452652015986 active site 452652015987 allantoicase; Provisional; Region: PRK13257 452652015988 Allantoicase repeat; Region: Allantoicase; pfam03561 452652015989 Allantoicase repeat; Region: Allantoicase; pfam03561 452652015990 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 452652015991 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 452652015992 tetramer interface [polypeptide binding]; other site 452652015993 heme binding pocket [chemical binding]; other site 452652015994 NADPH binding site [chemical binding]; other site 452652015995 Bacterial transcriptional regulator; Region: IclR; pfam01614 452652015996 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 452652015997 Protein of unknown function (DUF3533); Region: DUF3533; pfam12051 452652015998 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 452652015999 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 452652016000 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 452652016001 CrcB-like protein; Region: CRCB; pfam02537 452652016002 Urea transporter; Region: UT; cl01829 452652016003 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 452652016004 alpha-gamma subunit interface [polypeptide binding]; other site 452652016005 beta-gamma subunit interface [polypeptide binding]; other site 452652016006 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 452652016007 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 452652016008 gamma-beta subunit interface [polypeptide binding]; other site 452652016009 alpha-beta subunit interface [polypeptide binding]; other site 452652016010 urease subunit alpha; Reviewed; Region: ureC; PRK13207 452652016011 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 452652016012 subunit interactions [polypeptide binding]; other site 452652016013 active site 452652016014 flap region; other site 452652016015 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 452652016016 UreF; Region: UreF; pfam01730 452652016017 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 452652016018 UreD urease accessory protein; Region: UreD; pfam01774 452652016019 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 452652016020 Part of AAA domain; Region: AAA_19; pfam13245 452652016021 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 452652016022 Short C-terminal domain; Region: SHOCT; pfam09851 452652016023 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 452652016024 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 452652016025 putative active site [active] 452652016026 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 452652016027 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 452652016028 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 452652016029 motif II; other site 452652016030 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 452652016031 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 452652016032 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 452652016033 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 452652016034 FMN-binding pocket [chemical binding]; other site 452652016035 flavin binding motif; other site 452652016036 phosphate binding motif [ion binding]; other site 452652016037 beta-alpha-beta structure motif; other site 452652016038 NAD binding pocket [chemical binding]; other site 452652016039 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 452652016040 catalytic loop [active] 452652016041 iron binding site [ion binding]; other site 452652016042 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 452652016043 active site 452652016044 short chain dehydrogenase; Validated; Region: PRK05855 452652016045 classical (c) SDRs; Region: SDR_c; cd05233 452652016046 NAD(P) binding site [chemical binding]; other site 452652016047 active site 452652016048 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 452652016049 Domain of unknown function (DUF397); Region: DUF397; pfam04149 452652016050 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 452652016051 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652016052 non-specific DNA binding site [nucleotide binding]; other site 452652016053 salt bridge; other site 452652016054 sequence-specific DNA binding site [nucleotide binding]; other site 452652016055 AAA domain; Region: AAA_18; pfam13238 452652016056 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 452652016057 active site 452652016058 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 452652016059 putative active site [active] 452652016060 putative metal binding residues [ion binding]; other site 452652016061 signature motif; other site 452652016062 putative triphosphate binding site [ion binding]; other site 452652016063 dimer interface [polypeptide binding]; other site 452652016064 probable molybdenum cofactor biosynthesis protein A, archaeal; Region: moaA_archaeal; TIGR02668 452652016065 putative pectinesterase; Region: PLN02432; cl01911 452652016066 parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805 452652016067 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 452652016068 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 452652016069 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 452652016070 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 452652016071 XdhC Rossmann domain; Region: XdhC_C; pfam13478 452652016072 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 452652016073 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 452652016074 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 452652016075 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 452652016076 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 452652016077 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 452652016078 catalytic loop [active] 452652016079 iron binding site [ion binding]; other site 452652016080 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 452652016081 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 452652016082 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 452652016083 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 452652016084 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 452652016085 Predicted esterase [General function prediction only]; Region: COG0627 452652016086 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 452652016087 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 452652016088 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 452652016089 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 452652016090 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 452652016091 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 452652016092 putative catalytic site [active] 452652016093 putative phosphate binding site [ion binding]; other site 452652016094 active site 452652016095 metal binding site A [ion binding]; metal-binding site 452652016096 DNA binding site [nucleotide binding] 452652016097 putative AP binding site [nucleotide binding]; other site 452652016098 putative metal binding site B [ion binding]; other site 452652016099 Predicted transcriptional regulators [Transcription]; Region: COG1695 452652016100 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 452652016101 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 452652016102 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 452652016103 Walker A/P-loop; other site 452652016104 ATP binding site [chemical binding]; other site 452652016105 Q-loop/lid; other site 452652016106 ABC transporter signature motif; other site 452652016107 Walker B; other site 452652016108 D-loop; other site 452652016109 H-loop/switch region; other site 452652016110 YhhN-like protein; Region: YhhN; pfam07947 452652016111 potential frameshift: common BLAST hit: gi|344998860|ref|YP_004801714.1| fatty acid hydroxylase 452652016112 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 452652016113 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 452652016114 Protein of unknown function (DUF2398); Region: DUF2398; cl09875 452652016115 Protein of unknown function (DUF2398); Region: DUF2398; cl09875 452652016116 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 452652016117 DNA-binding site [nucleotide binding]; DNA binding site 452652016118 RNA-binding motif; other site 452652016119 BCCT family transporter; Region: BCCT; pfam02028 452652016120 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652016121 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652016122 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 452652016123 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 452652016124 active site 452652016125 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 452652016126 catalytic triad [active] 452652016127 dimer interface [polypeptide binding]; other site 452652016128 SWIM zinc finger; Region: SWIM; pfam04434 452652016129 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 452652016130 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 452652016131 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 452652016132 putative active site [active] 452652016133 putative catalytic site [active] 452652016134 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 452652016135 This domain family includes a range of different proteins. Such as antifreeze proteins and flagellar FlgA proteins, and CpaB pilus proteins; Region: SAF; smart00858 452652016136 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 452652016137 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 452652016138 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 452652016139 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 452652016140 Walker A motif; other site 452652016141 ATP binding site [chemical binding]; other site 452652016142 Walker B motif; other site 452652016143 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 452652016144 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 452652016145 Bacterial transcriptional activator domain; Region: BTAD; smart01043 452652016146 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 452652016147 dimer interface [polypeptide binding]; other site 452652016148 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 452652016149 active site 452652016150 NTP binding site [chemical binding]; other site 452652016151 metal binding triad [ion binding]; metal-binding site 452652016152 antibiotic binding site [chemical binding]; other site 452652016153 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 452652016154 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 452652016155 Possible enoyl reductase; Region: MDR_enoyl_red; cd08244 452652016156 putative NAD(P) binding site [chemical binding]; other site 452652016157 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 452652016158 putative dimer interface [polypeptide binding]; other site 452652016159 catalytic triad [active] 452652016160 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 452652016161 Transcriptional regulators [Transcription]; Region: MarR; COG1846 452652016162 putative DNA binding site [nucleotide binding]; other site 452652016163 putative Zn2+ binding site [ion binding]; other site 452652016164 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 452652016165 conserved cys residue [active] 452652016166 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652016167 NAD(P) binding site [chemical binding]; other site 452652016168 active site 452652016169 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 452652016170 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 452652016171 dimer interface [polypeptide binding]; other site 452652016172 active site 452652016173 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 452652016174 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 452652016175 active site 452652016176 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652016177 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652016178 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 452652016179 Phosphotransferase enzyme family; Region: APH; pfam01636 452652016180 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 452652016181 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 452652016182 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 452652016183 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 452652016184 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 452652016185 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 452652016186 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 452652016187 putative active site [active] 452652016188 putative dimer interface [polypeptide binding]; other site 452652016189 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 452652016190 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 452652016191 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 452652016192 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 452652016193 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 452652016194 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652016195 homodimer interface [polypeptide binding]; other site 452652016196 catalytic residue [active] 452652016197 O-methyltransferase; Region: Methyltransf_2; pfam00891 452652016198 putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208 452652016199 oligomer interface [polypeptide binding]; other site 452652016200 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 452652016201 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 452652016202 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 452652016203 CBD_II domain; Region: CBD_II; smart00637 452652016204 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 452652016205 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652016206 S-adenosylmethionine binding site [chemical binding]; other site 452652016207 PAS domain S-box; Region: sensory_box; TIGR00229 452652016208 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452652016209 putative active site [active] 452652016210 heme pocket [chemical binding]; other site 452652016211 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 452652016212 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 452652016213 metal binding site [ion binding]; metal-binding site 452652016214 active site 452652016215 I-site; other site 452652016216 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 452652016217 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 452652016218 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 452652016219 dimerization interface [polypeptide binding]; other site 452652016220 active site 452652016221 CHAT domain; Region: CHAT; pfam12770 452652016222 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 452652016223 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 452652016224 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 452652016225 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 452652016226 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 452652016227 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 452652016228 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 452652016229 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 452652016230 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 452652016231 putative NAD(P) binding site [chemical binding]; other site 452652016232 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 452652016233 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 452652016234 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 452652016235 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 452652016236 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 452652016237 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 452652016238 putative active site [active] 452652016239 catalytic triad [active] 452652016240 putative dimer interface [polypeptide binding]; other site 452652016241 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 452652016242 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 452652016243 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 452652016244 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 452652016245 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 452652016246 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 452652016247 Precorrin-8X methylmutase; Region: CbiC; pfam02570 452652016248 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 452652016249 active site 452652016250 SAM binding site [chemical binding]; other site 452652016251 homodimer interface [polypeptide binding]; other site 452652016252 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 452652016253 active site 452652016254 SAM binding site [chemical binding]; other site 452652016255 homodimer interface [polypeptide binding]; other site 452652016256 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 452652016257 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 452652016258 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 452652016259 homotrimer interaction site [polypeptide binding]; other site 452652016260 putative active site [active] 452652016261 Transcriptional regulator [Transcription]; Region: IclR; COG1414 452652016262 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 452652016263 Bacterial transcriptional regulator; Region: IclR; pfam01614 452652016264 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 452652016265 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 452652016266 substrate binding site [chemical binding]; other site 452652016267 ATP binding site [chemical binding]; other site 452652016268 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 452652016269 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 452652016270 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 452652016271 catalytic residue [active] 452652016272 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 452652016273 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 452652016274 active site 452652016275 putative substrate binding pocket [chemical binding]; other site 452652016276 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 452652016277 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 452652016278 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 452652016279 active site 452652016280 intersubunit interface [polypeptide binding]; other site 452652016281 catalytic residue [active] 452652016282 IPT/TIG domain; Region: TIG; pfam01833 452652016283 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 452652016284 active site 452652016285 SAM binding site [chemical binding]; other site 452652016286 homodimer interface [polypeptide binding]; other site 452652016287 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 452652016288 active site 452652016289 putative homodimer interface [polypeptide binding]; other site 452652016290 SAM binding site [chemical binding]; other site 452652016291 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 452652016292 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 452652016293 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 452652016294 MarR family; Region: MarR_2; pfam12802 452652016295 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 452652016296 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777 452652016297 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 452652016298 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 452652016299 Transcriptional regulator; Region: Rrf2; cl17282 452652016300 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 452652016301 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 452652016302 heme-binding site [chemical binding]; other site 452652016303 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 452652016304 FAD binding pocket [chemical binding]; other site 452652016305 FAD binding motif [chemical binding]; other site 452652016306 phosphate binding motif [ion binding]; other site 452652016307 beta-alpha-beta structure motif; other site 452652016308 NAD binding pocket [chemical binding]; other site 452652016309 Heme binding pocket [chemical binding]; other site 452652016310 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 452652016311 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 452652016312 PYR/PP interface [polypeptide binding]; other site 452652016313 dimer interface [polypeptide binding]; other site 452652016314 TPP binding site [chemical binding]; other site 452652016315 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 452652016316 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 452652016317 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 452652016318 tetramer interface [polypeptide binding]; other site 452652016319 TPP-binding site [chemical binding]; other site 452652016320 heterodimer interface [polypeptide binding]; other site 452652016321 phosphorylation loop region [posttranslational modification] 452652016322 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 452652016323 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 452652016324 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 452652016325 dimer interface [polypeptide binding]; other site 452652016326 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 452652016327 active site 452652016328 Fe binding site [ion binding]; other site 452652016329 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 452652016330 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 452652016331 dimer interface [polypeptide binding]; other site 452652016332 active site 452652016333 AMP-binding enzyme; Region: AMP-binding; pfam00501 452652016334 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452652016335 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452652016336 acyl-activating enzyme (AAE) consensus motif; other site 452652016337 acyl-activating enzyme (AAE) consensus motif; other site 452652016338 AMP binding site [chemical binding]; other site 452652016339 active site 452652016340 CoA binding site [chemical binding]; other site 452652016341 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 452652016342 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 452652016343 active site 452652016344 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 452652016345 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452652016346 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452652016347 acyl-activating enzyme (AAE) consensus motif; other site 452652016348 acyl-activating enzyme (AAE) consensus motif; other site 452652016349 AMP binding site [chemical binding]; other site 452652016350 active site 452652016351 CoA binding site [chemical binding]; other site 452652016352 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 452652016353 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 452652016354 active site 452652016355 substrate binding site [chemical binding]; other site 452652016356 FMN binding site [chemical binding]; other site 452652016357 putative catalytic residues [active] 452652016358 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 452652016359 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 452652016360 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 452652016361 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 452652016362 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 452652016363 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652016364 homodimer interface [polypeptide binding]; other site 452652016365 catalytic residue [active] 452652016366 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 452652016367 ABC-2 type transporter; Region: ABC2_membrane; cl17235 452652016368 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 452652016369 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652016370 Walker A/P-loop; other site 452652016371 ATP binding site [chemical binding]; other site 452652016372 Q-loop/lid; other site 452652016373 ABC transporter signature motif; other site 452652016374 Walker B; other site 452652016375 D-loop; other site 452652016376 H-loop/switch region; other site 452652016377 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 452652016378 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 452652016379 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 452652016380 active site 452652016381 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 452652016382 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 452652016383 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 452652016384 hypothetical protein; Validated; Region: PRK07080 452652016385 Condensation domain; Region: Condensation; pfam00668 452652016386 Condensation domain; Region: Condensation; pfam00668 452652016387 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 452652016388 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 452652016389 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452652016390 Coenzyme A binding pocket [chemical binding]; other site 452652016391 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 452652016392 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 452652016393 putative active site [active] 452652016394 PAS fold; Region: PAS; pfam00989 452652016395 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 452652016396 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 452652016397 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 452652016398 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 452652016399 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 452652016400 ATP binding site [chemical binding]; other site 452652016401 Mg2+ binding site [ion binding]; other site 452652016402 G-X-G motif; other site 452652016403 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 452652016404 Catalytic domain of Protein Kinases; Region: PKc; cd00180 452652016405 active site 452652016406 ATP binding site [chemical binding]; other site 452652016407 substrate binding site [chemical binding]; other site 452652016408 activation loop (A-loop); other site 452652016409 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 452652016410 peptide binding site [polypeptide binding]; other site 452652016411 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 452652016412 Predicted transcriptional regulators [Transcription]; Region: COG1733 452652016413 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 452652016414 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652016415 NADH(P)-binding; Region: NAD_binding_10; pfam13460 452652016416 NAD(P) binding site [chemical binding]; other site 452652016417 active site 452652016418 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 452652016419 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452652016420 acyl-activating enzyme (AAE) consensus motif; other site 452652016421 AMP binding site [chemical binding]; other site 452652016422 active site 452652016423 CoA binding site [chemical binding]; other site 452652016424 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652016425 NAD(P) binding site [chemical binding]; other site 452652016426 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652016427 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 452652016428 active site 452652016429 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 452652016430 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652016431 NAD(P) binding site [chemical binding]; other site 452652016432 active site 452652016433 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 452652016434 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 452652016435 active site 452652016436 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652016437 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652016438 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 452652016439 active site 452652016440 catalytic residues [active] 452652016441 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 452652016442 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 452652016443 dimer interface [polypeptide binding]; other site 452652016444 active site 452652016445 CoA binding pocket [chemical binding]; other site 452652016446 acyl-CoA synthetase; Validated; Region: PRK05850 452652016447 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 452652016448 acyl-activating enzyme (AAE) consensus motif; other site 452652016449 active site 452652016450 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 452652016451 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 452652016452 NAD(P) binding site [chemical binding]; other site 452652016453 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 452652016454 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 452652016455 active site 452652016456 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 452652016457 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 452652016458 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 452652016459 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 452652016460 active site 452652016461 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 452652016462 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 452652016463 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 452652016464 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 452652016465 NADP binding site [chemical binding]; other site 452652016466 active site 452652016467 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 452652016468 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 452652016469 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 452652016470 active site 452652016471 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 452652016472 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 452652016473 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 452652016474 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 452652016475 putative NADP binding site [chemical binding]; other site 452652016476 active site 452652016477 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 452652016478 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 452652016479 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 452652016480 active site 452652016481 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 452652016482 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 452652016483 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 452652016484 Erythronolide synthase docking; Region: Docking; pfam08990 452652016485 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 452652016486 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 452652016487 active site 452652016488 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 452652016489 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 452652016490 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 452652016491 Thioesterase; Region: PKS_TE; smart00824 452652016492 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652016493 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 452652016494 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652016495 putative substrate translocation pore; other site 452652016496 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 452652016497 AAA ATPase domain; Region: AAA_16; pfam13191 452652016498 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652016499 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652016500 dimerization interface [polypeptide binding]; other site 452652016501 DNA binding residues [nucleotide binding] 452652016502 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 452652016503 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 452652016504 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 452652016505 Walker A/P-loop; other site 452652016506 ATP binding site [chemical binding]; other site 452652016507 Q-loop/lid; other site 452652016508 ABC transporter signature motif; other site 452652016509 Walker B; other site 452652016510 D-loop; other site 452652016511 H-loop/switch region; other site 452652016512 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 452652016513 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 452652016514 Walker A/P-loop; other site 452652016515 ATP binding site [chemical binding]; other site 452652016516 Q-loop/lid; other site 452652016517 ABC transporter signature motif; other site 452652016518 Walker B; other site 452652016519 D-loop; other site 452652016520 H-loop/switch region; other site 452652016521 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 452652016522 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 452652016523 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652016524 putative PBP binding loops; other site 452652016525 ABC-ATPase subunit interface; other site 452652016526 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 452652016527 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 452652016528 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 452652016529 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 452652016530 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 452652016531 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 452652016532 dimerization interface [polypeptide binding]; other site 452652016533 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 452652016534 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 452652016535 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 452652016536 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 452652016537 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652016538 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452652016539 DNA binding residues [nucleotide binding] 452652016540 Histidine kinase; Region: HisKA_3; pfam07730 452652016541 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652016542 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652016543 active site 452652016544 phosphorylation site [posttranslational modification] 452652016545 intermolecular recognition site; other site 452652016546 dimerization interface [polypeptide binding]; other site 452652016547 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652016548 DNA binding residues [nucleotide binding] 452652016549 dimerization interface [polypeptide binding]; other site 452652016550 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 452652016551 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 452652016552 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 452652016553 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 452652016554 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 452652016555 active site 452652016556 conformational flexibility of ligand binding pocket; other site 452652016557 ADP-ribosylating toxin turn-turn motif; other site 452652016558 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 452652016559 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 452652016560 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal; Region: ACP_syn_III_C; pfam08541 452652016561 ATP-grasp domain; Region: ATP-grasp_4; cl17255 452652016562 pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099 452652016563 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839 452652016564 dimer interface [polypeptide binding]; other site 452652016565 active site 452652016566 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 452652016567 catalytic residues [active] 452652016568 substrate binding site [chemical binding]; other site 452652016569 acyl carrier protein; Provisional; Region: PRK07639 452652016570 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 452652016571 active site 452652016572 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 452652016573 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 452652016574 active site 452652016575 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 452652016576 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 452652016577 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652016578 NAD(P) binding site [chemical binding]; other site 452652016579 active site 452652016580 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 452652016581 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 452652016582 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 452652016583 dimer interface [polypeptide binding]; other site 452652016584 active site 452652016585 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 452652016586 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452652016587 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 452652016588 acyl-activating enzyme (AAE) consensus motif; other site 452652016589 AMP binding site [chemical binding]; other site 452652016590 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 452652016591 Condensation domain; Region: Condensation; pfam00668 452652016592 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 452652016593 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652016594 non-specific DNA binding site [nucleotide binding]; other site 452652016595 salt bridge; other site 452652016596 sequence-specific DNA binding site [nucleotide binding]; other site 452652016597 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 452652016598 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038 452652016599 Dimer interface [polypeptide binding]; other site 452652016600 Lsr2; Region: Lsr2; pfam11774 452652016601 Helix-turn-helix domain; Region: HTH_17; pfam12728 452652016602 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 452652016603 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 452652016604 active site 452652016605 DNA binding site [nucleotide binding] 452652016606 Int/Topo IB signature motif; other site 452652016607 hypothetical protein; Provisional; Region: PRK07906 452652016608 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 452652016609 putative metal binding site [ion binding]; other site 452652016610 Small secreted domain (DUF320); Region: DUF320; pfam03777 452652016611 Small secreted domain (DUF320); Region: DUF320; pfam03777 452652016612 Small secreted domain (DUF320); Region: DUF320; pfam03777 452652016613 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 452652016614 AAA domain; Region: AAA_22; pfam13401 452652016615 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452652016616 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452652016617 binding surface 452652016618 TPR motif; other site 452652016619 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452652016620 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 452652016621 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 452652016622 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 452652016623 active site 452652016624 catalytic tetrad [active] 452652016625 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 452652016626 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 452652016627 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 452652016628 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 452652016629 substrate binding pocket [chemical binding]; other site 452652016630 membrane-bound complex binding site; other site 452652016631 hinge residues; other site 452652016632 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 452652016633 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 452652016634 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 452652016635 NAD(P) binding site [chemical binding]; other site 452652016636 benzoylformate decarboxylase; Reviewed; Region: PRK07092 452652016637 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 452652016638 PYR/PP interface [polypeptide binding]; other site 452652016639 dimer interface [polypeptide binding]; other site 452652016640 TPP binding site [chemical binding]; other site 452652016641 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 452652016642 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 452652016643 TPP-binding site [chemical binding]; other site 452652016644 dimer interface [polypeptide binding]; other site 452652016645 Short repeats of unknown function; Region: ALF; pfam03752 452652016646 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 452652016647 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 452652016648 oligomer interface [polypeptide binding]; other site 452652016649 metal binding site [ion binding]; metal-binding site 452652016650 metal binding site [ion binding]; metal-binding site 452652016651 putative Cl binding site [ion binding]; other site 452652016652 basic sphincter; other site 452652016653 hydrophobic gate; other site 452652016654 periplasmic entrance; other site 452652016655 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 452652016656 catalytic core [active] 452652016657 Protein of unknown function (DUF3090); Region: DUF3090; pfam11290 452652016658 conserved hypothetical protein; Region: TIGR03843 452652016659 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 452652016660 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 452652016661 active site 452652016662 HIGH motif; other site 452652016663 nucleotide binding site [chemical binding]; other site 452652016664 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 452652016665 active site 452652016666 KMSKS motif; other site 452652016667 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 452652016668 anticodon binding site; other site 452652016669 tRNA binding surface [nucleotide binding]; other site 452652016670 PAC2 family; Region: PAC2; pfam09754 452652016671 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 452652016672 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 452652016673 NAD binding site [chemical binding]; other site 452652016674 substrate binding site [chemical binding]; other site 452652016675 catalytic Zn binding site [ion binding]; other site 452652016676 tetramer interface [polypeptide binding]; other site 452652016677 structural Zn binding site [ion binding]; other site 452652016678 Transcriptional regulators [Transcription]; Region: PurR; COG1609 452652016679 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 452652016680 DNA binding site [nucleotide binding] 452652016681 domain linker motif; other site 452652016682 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 452652016683 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 452652016684 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 452652016685 sugar binding site [chemical binding]; other site 452652016686 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 452652016687 sugar binding site [chemical binding]; other site 452652016688 CARDB; Region: CARDB; pfam07705 452652016689 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 452652016690 putative metal binding site [ion binding]; other site 452652016691 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 452652016692 Transcriptional regulators [Transcription]; Region: PurR; COG1609 452652016693 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 452652016694 DNA binding site [nucleotide binding] 452652016695 domain linker motif; other site 452652016696 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 452652016697 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 452652016698 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 452652016699 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 452652016700 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 452652016701 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652016702 dimer interface [polypeptide binding]; other site 452652016703 conserved gate region; other site 452652016704 putative PBP binding loops; other site 452652016705 ABC-ATPase subunit interface; other site 452652016706 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 452652016707 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652016708 dimer interface [polypeptide binding]; other site 452652016709 conserved gate region; other site 452652016710 putative PBP binding loops; other site 452652016711 ABC-ATPase subunit interface; other site 452652016712 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 452652016713 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 452652016714 active site 452652016715 catalytic site [active] 452652016716 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 452652016717 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 452652016718 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 452652016719 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 452652016720 substrate binding pocket [chemical binding]; other site 452652016721 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 452652016722 B12 binding site [chemical binding]; other site 452652016723 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 452652016724 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 452652016725 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 452652016726 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 452652016727 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 452652016728 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652016729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652016730 active site 452652016731 phosphorylation site [posttranslational modification] 452652016732 intermolecular recognition site; other site 452652016733 dimerization interface [polypeptide binding]; other site 452652016734 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652016735 DNA binding residues [nucleotide binding] 452652016736 dimerization interface [polypeptide binding]; other site 452652016737 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 452652016738 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 452652016739 active site 452652016740 Peptidase family M50; Region: Peptidase_M50; pfam02163 452652016741 putative substrate binding region [chemical binding]; other site 452652016742 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 452652016743 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 452652016744 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652016745 S-adenosylmethionine binding site [chemical binding]; other site 452652016746 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 452652016747 proteasome ATPase; Region: pup_AAA; TIGR03689 452652016748 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452652016749 Walker A motif; other site 452652016750 ATP binding site [chemical binding]; other site 452652016751 Walker B motif; other site 452652016752 arginine finger; other site 452652016753 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 452652016754 Pup-like protein; Region: Pup; pfam05639 452652016755 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 452652016756 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 452652016757 active site 452652016758 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 452652016759 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 452652016760 active site 452652016761 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 452652016762 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 452652016763 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 452652016764 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 452652016765 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 452652016766 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 452652016767 Predicted transcriptional regulator [Transcription]; Region: COG2378 452652016768 WYL domain; Region: WYL; pfam13280 452652016769 Predicted transcriptional regulator [Transcription]; Region: COG2378 452652016770 WYL domain; Region: WYL; pfam13280 452652016771 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 452652016772 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 452652016773 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 452652016774 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 452652016775 hydroxyglutarate oxidase; Provisional; Region: PRK11728 452652016776 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 452652016777 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 452652016778 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 452652016779 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 452652016780 inhibitor site; inhibition site 452652016781 active site 452652016782 dimer interface [polypeptide binding]; other site 452652016783 catalytic residue [active] 452652016784 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 452652016785 Proline racemase; Region: Pro_racemase; pfam05544 452652016786 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 452652016787 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 452652016788 NAD(P) binding site [chemical binding]; other site 452652016789 catalytic residues [active] 452652016790 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 452652016791 Proline racemase; Region: Pro_racemase; pfam05544 452652016792 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 452652016793 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 452652016794 Transcriptional regulators [Transcription]; Region: GntR; COG1802 452652016795 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 452652016796 DNA-binding site [nucleotide binding]; DNA binding site 452652016797 FCD domain; Region: FCD; pfam07729 452652016798 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 452652016799 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 452652016800 Walker A/P-loop; other site 452652016801 ATP binding site [chemical binding]; other site 452652016802 Q-loop/lid; other site 452652016803 ABC transporter signature motif; other site 452652016804 Walker B; other site 452652016805 D-loop; other site 452652016806 H-loop/switch region; other site 452652016807 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452652016808 FtsX-like permease family; Region: FtsX; pfam02687 452652016809 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 452652016810 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 452652016811 Histidine kinase; Region: HisKA_3; pfam07730 452652016812 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452652016813 ATP binding site [chemical binding]; other site 452652016814 G-X-G motif; other site 452652016815 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652016816 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652016817 active site 452652016818 phosphorylation site [posttranslational modification] 452652016819 intermolecular recognition site; other site 452652016820 dimerization interface [polypeptide binding]; other site 452652016821 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652016822 DNA binding residues [nucleotide binding] 452652016823 Proteins of 100 residues with WXG; Region: WXG100; cl02005 452652016824 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 452652016825 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 452652016826 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652016827 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652016828 Uncharacterized conserved protein [Function unknown]; Region: COG2128 452652016829 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 452652016830 Nitronate monooxygenase; Region: NMO; pfam03060 452652016831 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 452652016832 FMN binding site [chemical binding]; other site 452652016833 substrate binding site [chemical binding]; other site 452652016834 putative catalytic residue [active] 452652016835 proline aminopeptidase P II; Provisional; Region: PRK10879 452652016836 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 452652016837 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 452652016838 active site 452652016839 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 452652016840 peptide binding site [polypeptide binding]; other site 452652016841 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 452652016842 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 452652016843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652016844 dimer interface [polypeptide binding]; other site 452652016845 conserved gate region; other site 452652016846 putative PBP binding loops; other site 452652016847 ABC-ATPase subunit interface; other site 452652016848 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 452652016849 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652016850 dimer interface [polypeptide binding]; other site 452652016851 conserved gate region; other site 452652016852 putative PBP binding loops; other site 452652016853 ABC-ATPase subunit interface; other site 452652016854 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 452652016855 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 452652016856 Walker A/P-loop; other site 452652016857 ATP binding site [chemical binding]; other site 452652016858 Q-loop/lid; other site 452652016859 ABC transporter signature motif; other site 452652016860 Walker B; other site 452652016861 D-loop; other site 452652016862 H-loop/switch region; other site 452652016863 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 452652016864 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 452652016865 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 452652016866 Walker A/P-loop; other site 452652016867 ATP binding site [chemical binding]; other site 452652016868 Q-loop/lid; other site 452652016869 ABC transporter signature motif; other site 452652016870 Walker B; other site 452652016871 D-loop; other site 452652016872 H-loop/switch region; other site 452652016873 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 452652016874 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 452652016875 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 452652016876 Melibiase; Region: Melibiase; pfam02065 452652016877 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652016878 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 452652016879 dimerization interface [polypeptide binding]; other site 452652016880 putative DNA binding site [nucleotide binding]; other site 452652016881 putative Zn2+ binding site [ion binding]; other site 452652016882 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 452652016883 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 452652016884 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 452652016885 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 452652016886 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 452652016887 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 452652016888 catalytic residue [active] 452652016889 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 452652016890 dimerization interface [polypeptide binding]; other site 452652016891 putative DNA binding site [nucleotide binding]; other site 452652016892 putative Zn2+ binding site [ion binding]; other site 452652016893 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 452652016894 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 452652016895 ATP binding site [chemical binding]; other site 452652016896 putative Mg++ binding site [ion binding]; other site 452652016897 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 452652016898 nucleotide binding region [chemical binding]; other site 452652016899 ATP-binding site [chemical binding]; other site 452652016900 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 452652016901 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 452652016902 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 452652016903 dimer interface [polypeptide binding]; other site 452652016904 PYR/PP interface [polypeptide binding]; other site 452652016905 TPP binding site [chemical binding]; other site 452652016906 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 452652016907 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 452652016908 TPP-binding site [chemical binding]; other site 452652016909 Transcriptional regulators [Transcription]; Region: PurR; COG1609 452652016910 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 452652016911 DNA binding site [nucleotide binding] 452652016912 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 452652016913 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 452652016914 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 452652016915 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 452652016916 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 452652016917 putative sugar binding sites [chemical binding]; other site 452652016918 Q-X-W motif; other site 452652016919 gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521 452652016920 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 452652016921 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 452652016922 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 452652016923 catalytic residue [active] 452652016924 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 452652016925 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 452652016926 PYR/PP interface [polypeptide binding]; other site 452652016927 dimer interface [polypeptide binding]; other site 452652016928 TPP binding site [chemical binding]; other site 452652016929 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 452652016930 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 452652016931 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 452652016932 tetramer interface [polypeptide binding]; other site 452652016933 TPP-binding site [chemical binding]; other site 452652016934 heterodimer interface [polypeptide binding]; other site 452652016935 phosphorylation loop region [posttranslational modification] 452652016936 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 452652016937 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 452652016938 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 452652016939 dimer interface [polypeptide binding]; other site 452652016940 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 452652016941 active site 452652016942 Fe binding site [ion binding]; other site 452652016943 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 452652016944 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 452652016945 dimer interface [polypeptide binding]; other site 452652016946 active site 452652016947 AMP-binding enzyme; Region: AMP-binding; pfam00501 452652016948 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452652016949 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452652016950 acyl-activating enzyme (AAE) consensus motif; other site 452652016951 acyl-activating enzyme (AAE) consensus motif; other site 452652016952 AMP binding site [chemical binding]; other site 452652016953 active site 452652016954 CoA binding site [chemical binding]; other site 452652016955 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 452652016956 active site 452652016957 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452652016958 AMP-binding enzyme; Region: AMP-binding; pfam00501 452652016959 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452652016960 acyl-activating enzyme (AAE) consensus motif; other site 452652016961 acyl-activating enzyme (AAE) consensus motif; other site 452652016962 AMP binding site [chemical binding]; other site 452652016963 active site 452652016964 CoA binding site [chemical binding]; other site 452652016965 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 452652016966 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 452652016967 active site 452652016968 substrate binding site [chemical binding]; other site 452652016969 FMN binding site [chemical binding]; other site 452652016970 putative catalytic residues [active] 452652016971 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 452652016972 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 452652016973 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 452652016974 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 452652016975 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652016976 homodimer interface [polypeptide binding]; other site 452652016977 catalytic residue [active] 452652016978 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 452652016979 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652016980 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 452652016981 Walker A/P-loop; other site 452652016982 ATP binding site [chemical binding]; other site 452652016983 Q-loop/lid; other site 452652016984 ABC transporter signature motif; other site 452652016985 Walker B; other site 452652016986 D-loop; other site 452652016987 H-loop/switch region; other site 452652016988 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 452652016989 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 452652016990 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 452652016991 active site 452652016992 TDP-binding site; other site 452652016993 acceptor substrate-binding pocket; other site 452652016994 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 452652016995 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal; Region: ACP_syn_III_C; pfam08541 452652016996 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 452652016997 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 452652016998 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 452652016999 DNA binding site [nucleotide binding] 452652017000 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 452652017001 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 452652017002 NB-ARC domain; Region: NB-ARC; pfam00931 452652017003 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652017004 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652017005 DNA binding residues [nucleotide binding] 452652017006 dimerization interface [polypeptide binding]; other site 452652017007 Helix-turn-helix domain; Region: HTH_17; pfam12728 452652017008 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 452652017009 NB-ARC domain; Region: NB-ARC; pfam00931 452652017010 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452652017011 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452652017012 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 452652017013 Catalytic domain of Protein Kinases; Region: PKc; cd00180 452652017014 active site 452652017015 substrate binding site [chemical binding]; other site 452652017016 ATP binding site [chemical binding]; other site 452652017017 activation loop (A-loop); other site 452652017018 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 452652017019 Domain of unknown function (DUF3893); Region: DUF3893; pfam13032 452652017020 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 452652017021 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 452652017022 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 452652017023 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 452652017024 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 452652017025 DDE superfamily endonuclease; Region: DDE_3; pfam13358 452652017026 Winged helix-turn helix; Region: HTH_29; pfam13551 452652017027 Winged helix-turn helix; Region: HTH_33; pfam13592 452652017028 PIN domain; Region: PIN; pfam01850 452652017029 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 452652017030 5'-3' exonuclease; Region: 53EXOc; smart00475 452652017031 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 452652017032 active site 452652017033 metal binding site 1 [ion binding]; metal-binding site 452652017034 putative 5' ssDNA interaction site; other site 452652017035 metal binding site 3; metal-binding site 452652017036 metal binding site 2 [ion binding]; metal-binding site 452652017037 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 452652017038 putative DNA binding site [nucleotide binding]; other site 452652017039 putative metal binding site [ion binding]; other site 452652017040 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 452652017041 Chromate transporter; Region: Chromate_transp; pfam02417 452652017042 Chromate transporter; Region: Chromate_transp; pfam02417 452652017043 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 452652017044 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 452652017045 catalytic triad [active] 452652017046 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 452652017047 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 452652017048 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652017049 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 452652017050 YCII-related domain; Region: YCII; cl00999 452652017051 Methyltransferase domain; Region: Methyltransf_31; pfam13847 452652017052 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652017053 S-adenosylmethionine binding site [chemical binding]; other site 452652017054 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 452652017055 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 452652017056 catalytic residue [active] 452652017057 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 452652017058 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 452652017059 substrate binding pocket [chemical binding]; other site 452652017060 substrate-Mg2+ binding site; other site 452652017061 aspartate-rich region 1; other site 452652017062 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 452652017063 Cytochrome P450; Region: p450; cl12078 452652017064 AAA domain; Region: AAA_33; pfam13671 452652017065 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 452652017066 active site 452652017067 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 452652017068 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452652017069 Coenzyme A binding pocket [chemical binding]; other site 452652017070 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 452652017071 CAAX protease self-immunity; Region: Abi; pfam02517 452652017072 H+ Antiporter protein; Region: 2A0121; TIGR00900 452652017073 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 452652017074 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 452652017075 Coenzyme A binding pocket [chemical binding]; other site 452652017076 Dienelactone hydrolase family; Region: DLH; pfam01738 452652017077 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 452652017078 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 452652017079 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652017080 putative substrate translocation pore; other site 452652017081 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652017082 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 452652017083 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 452652017084 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 452652017085 DNA-binding site [nucleotide binding]; DNA binding site 452652017086 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 452652017087 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652017088 homodimer interface [polypeptide binding]; other site 452652017089 catalytic residue [active] 452652017090 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 452652017091 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 452652017092 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 452652017093 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 452652017094 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 452652017095 MarR family; Region: MarR_2; pfam12802 452652017096 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 452652017097 adenylosuccinate lyase; Region: purB; TIGR00928 452652017098 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 452652017099 tetramer interface [polypeptide binding]; other site 452652017100 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652017101 NAD(P) binding site [chemical binding]; other site 452652017102 active site 452652017103 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652017104 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652017105 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 452652017106 putative substrate translocation pore; other site 452652017107 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 452652017108 hypothetical protein; Provisional; Region: PRK07945 452652017109 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 452652017110 active site 452652017111 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 452652017112 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 452652017113 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 452652017114 intracellular protease, PfpI family; Region: PfpI; TIGR01382 452652017115 conserved cys residue [active] 452652017116 TIGR03086 family protein; Region: TIGR03086 452652017117 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 452652017118 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652017119 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652017120 Major Facilitator Superfamily; Region: MFS_1; pfam07690 452652017121 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652017122 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652017123 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 452652017124 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 452652017125 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 452652017126 putative Zn2+ binding site [ion binding]; other site 452652017127 putative DNA binding site [nucleotide binding]; other site 452652017128 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 452652017129 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 452652017130 active site 452652017131 catalytic triad [active] 452652017132 oxyanion hole [active] 452652017133 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in uncharacterized protein from Archaeoglobus fulgidus (Af0060) and its bacterial homologs; Region: NTP-PPase_Af0060_like; cd11533 452652017134 homodimer interface [polypeptide binding]; other site 452652017135 metal binding site [ion binding]; metal-binding site 452652017136 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 452652017137 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 452652017138 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 452652017139 putative metal binding site [ion binding]; other site 452652017140 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 452652017141 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 452652017142 active site 452652017143 catalytic tetrad [active] 452652017144 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cd02106 452652017145 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 452652017146 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452652017147 Coenzyme A binding pocket [chemical binding]; other site 452652017148 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 452652017149 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 452652017150 active site 452652017151 catalytic triad [active] 452652017152 oxyanion hole [active] 452652017153 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 452652017154 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 452652017155 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 452652017156 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 452652017157 active site 452652017158 NTP binding site [chemical binding]; other site 452652017159 metal binding triad [ion binding]; metal-binding site 452652017160 antibiotic binding site [chemical binding]; other site 452652017161 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 452652017162 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 452652017163 GAF domain; Region: GAF; cl17456 452652017164 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 452652017165 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 452652017166 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 452652017167 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 452652017168 active site residue [active] 452652017169 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 452652017170 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 452652017171 active site residue [active] 452652017172 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 452652017173 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 452652017174 active site residue [active] 452652017175 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 452652017176 active site residue [active] 452652017177 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 452652017178 putative homotetramer interface [polypeptide binding]; other site 452652017179 putative homodimer interface [polypeptide binding]; other site 452652017180 putative allosteric switch controlling residues; other site 452652017181 putative metal binding site [ion binding]; other site 452652017182 putative homodimer-homodimer interface [polypeptide binding]; other site 452652017183 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 452652017184 putative homodimer interface [polypeptide binding]; other site 452652017185 putative homotetramer interface [polypeptide binding]; other site 452652017186 putative allosteric switch controlling residues; other site 452652017187 putative metal binding site [ion binding]; other site 452652017188 putative homodimer-homodimer interface [polypeptide binding]; other site 452652017189 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 452652017190 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 452652017191 putative acyl-acceptor binding pocket; other site 452652017192 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 452652017193 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 452652017194 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 452652017195 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 452652017196 Methyltransferase domain; Region: Methyltransf_31; pfam13847 452652017197 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652017198 S-adenosylmethionine binding site [chemical binding]; other site 452652017199 MarR family; Region: MarR; pfam01047 452652017200 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 452652017201 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 452652017202 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 452652017203 [4Fe-4S] binding site [ion binding]; other site 452652017204 molybdopterin cofactor binding site; other site 452652017205 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 452652017206 molybdopterin cofactor binding site; other site 452652017207 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 452652017208 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 452652017209 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 452652017210 iron-sulfur cluster [ion binding]; other site 452652017211 [2Fe-2S] cluster binding site [ion binding]; other site 452652017212 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 452652017213 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 452652017214 Short C-terminal domain; Region: SHOCT; pfam09851 452652017215 PAS domain; Region: PAS_9; pfam13426 452652017216 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452652017217 putative active site [active] 452652017218 PAS fold; Region: PAS_3; pfam08447 452652017219 heme pocket [chemical binding]; other site 452652017220 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 452652017221 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452652017222 PAS domain; Region: PAS_9; pfam13426 452652017223 putative active site [active] 452652017224 heme pocket [chemical binding]; other site 452652017225 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 452652017226 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 452652017227 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 452652017228 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 452652017229 ATP binding site [chemical binding]; other site 452652017230 Mg2+ binding site [ion binding]; other site 452652017231 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 452652017232 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 452652017233 active site 452652017234 catalytic tetrad [active] 452652017235 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 452652017236 dimer interface [polypeptide binding]; other site 452652017237 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 452652017238 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 452652017239 Ligand Binding Site [chemical binding]; other site 452652017240 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 452652017241 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 452652017242 Ligand binding site [chemical binding]; other site 452652017243 Electron transfer flavoprotein domain; Region: ETF; pfam01012 452652017244 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 452652017245 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652017246 S-adenosylmethionine binding site [chemical binding]; other site 452652017247 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 452652017248 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652017249 non-specific DNA binding site [nucleotide binding]; other site 452652017250 salt bridge; other site 452652017251 sequence-specific DNA binding site [nucleotide binding]; other site 452652017252 Cupin domain; Region: Cupin_2; pfam07883 452652017253 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 452652017254 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 452652017255 MoxR-like ATPases [General function prediction only]; Region: COG0714 452652017256 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452652017257 Walker A motif; other site 452652017258 ATP binding site [chemical binding]; other site 452652017259 Walker B motif; other site 452652017260 arginine finger; other site 452652017261 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 452652017262 Transcription factor WhiB; Region: Whib; pfam02467 452652017263 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 452652017264 anti sigma factor interaction site; other site 452652017265 regulatory phosphorylation site [posttranslational modification]; other site 452652017266 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 452652017267 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652017268 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 452652017269 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452652017270 DNA binding residues [nucleotide binding] 452652017271 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 452652017272 hydrophobic ligand binding site; other site 452652017273 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 452652017274 PRC-barrel domain; Region: PRC; pfam05239 452652017275 Transcriptional regulators [Transcription]; Region: MarR; COG1846 452652017276 MarR family; Region: MarR_2; pfam12802 452652017277 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 452652017278 Leucine carboxyl methyltransferase; Region: LCM; cl01306 452652017279 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 452652017280 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 452652017281 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 452652017282 Interdomain contacts; other site 452652017283 Cellulose binding domain; Region: CBM_2; pfam00553 452652017284 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 452652017285 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 452652017286 putative substrate binding site [chemical binding]; other site 452652017287 putative ATP binding site [chemical binding]; other site 452652017288 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 452652017289 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 452652017290 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652017291 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 452652017292 NAD(P) binding site [chemical binding]; other site 452652017293 active site 452652017294 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652017295 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652017296 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 452652017297 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 452652017298 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 452652017299 Predicted transcriptional regulators [Transcription]; Region: COG1733 452652017300 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 452652017301 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805 452652017302 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 452652017303 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 452652017304 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 452652017305 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 452652017306 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 452652017307 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 452652017308 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 452652017309 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 452652017310 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 452652017311 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 452652017312 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 452652017313 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 452652017314 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 452652017315 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 452652017316 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 452652017317 Cupin domain; Region: Cupin_2; pfam07883 452652017318 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 452652017319 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652017320 Walker A/P-loop; other site 452652017321 ATP binding site [chemical binding]; other site 452652017322 Q-loop/lid; other site 452652017323 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652017324 ABC transporter signature motif; other site 452652017325 Walker B; other site 452652017326 D-loop; other site 452652017327 H-loop/switch region; other site 452652017328 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452652017329 Walker A/P-loop; other site 452652017330 ATP binding site [chemical binding]; other site 452652017331 Q-loop/lid; other site 452652017332 ABC transporter signature motif; other site 452652017333 Walker B; other site 452652017334 D-loop; other site 452652017335 H-loop/switch region; other site 452652017336 Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317 452652017337 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 452652017338 active site 452652017339 Ca binding site [ion binding]; other site 452652017340 catalytic site [active] 452652017341 Aamy_C domain; Region: Aamy_C; smart00632 452652017342 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 452652017343 starch-binding site 2 [chemical binding]; other site 452652017344 starch-binding site 1 [chemical binding]; other site 452652017345 Alpha-amylase, C-terminal CBM20 (carbohydrate-binding module, family 20) domain. This domain is found in several bacterial and fungal alpha-amylases including the maltopentaose-forming amylases (G5-amylases). Most alpha-amylases have, in addition to the...; Region: CBM20_alpha_amylase; cd05808 452652017346 starch-binding site 2 [chemical binding]; other site 452652017347 starch-binding site 1 [chemical binding]; other site 452652017348 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 452652017349 putative hydrophobic ligand binding site [chemical binding]; other site 452652017350 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652017351 Predicted transcriptional regulators [Transcription]; Region: COG1733 452652017352 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 452652017353 SnoaL-like domain; Region: SnoaL_2; pfam12680 452652017354 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 452652017355 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452652017356 active site 452652017357 phosphorylation site [posttranslational modification] 452652017358 intermolecular recognition site; other site 452652017359 dimerization interface [polypeptide binding]; other site 452652017360 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 452652017361 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 452652017362 galactonate dehydratase; Provisional; Region: PRK14017 452652017363 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 452652017364 FAD binding domain; Region: FAD_binding_4; pfam01565 452652017365 Berberine and berberine like; Region: BBE; pfam08031 452652017366 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 452652017367 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652017368 putative substrate translocation pore; other site 452652017369 Predicted transcriptional regulators [Transcription]; Region: COG1695 452652017370 Transcriptional regulator PadR-like family; Region: PadR; cl17335 452652017371 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 452652017372 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 452652017373 SCP-2 sterol transfer family; Region: SCP2; pfam02036 452652017374 Uncharacterized conserved protein [Function unknown]; Region: COG3391 452652017375 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 452652017376 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 452652017377 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 452652017378 Tubby C 2; Region: Tub_2; cl02043 452652017379 Streptomyces extracellular neutral proteinase (M7) family; Region: Peptidase_M7; pfam02031 452652017380 Transcriptional regulator [Transcription]; Region: LysR; COG0583 452652017381 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 452652017382 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 452652017383 substrate binding pocket [chemical binding]; other site 452652017384 dimerization interface [polypeptide binding]; other site 452652017385 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 452652017386 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 452652017387 NodB motif; other site 452652017388 active site 452652017389 catalytic site [active] 452652017390 metal binding site [ion binding]; metal-binding site 452652017391 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652017392 non-specific DNA binding site [nucleotide binding]; other site 452652017393 salt bridge; other site 452652017394 sequence-specific DNA binding site [nucleotide binding]; other site 452652017395 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 452652017396 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 452652017397 oligomer interface [polypeptide binding]; other site 452652017398 active site residues [active] 452652017399 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 452652017400 Bacterial transcriptional activator domain; Region: BTAD; smart01043 452652017401 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 452652017402 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 452652017403 oligomer interface [polypeptide binding]; other site 452652017404 active site residues [active] 452652017405 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 452652017406 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 452652017407 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 452652017408 catalytic residue [active] 452652017409 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 452652017410 dimerization interface [polypeptide binding]; other site 452652017411 putative DNA binding site [nucleotide binding]; other site 452652017412 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 452652017413 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 452652017414 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 452652017415 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 452652017416 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 452652017417 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 452652017418 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 452652017419 Protein of unknown function (DUF690); Region: DUF690; cl04939 452652017420 Protein of unknown function (DUF690); Region: DUF690; cl04939 452652017421 Proteins of 100 residues with WXG; Region: WXG100; cl02005 452652017422 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12690 452652017423 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 452652017424 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 452652017425 Right handed beta helix region; Region: Beta_helix; pfam13229 452652017426 Right handed beta helix region; Region: Beta_helix; pfam13229 452652017427 stage V sporulation protein K; Region: spore_V_K; TIGR02881 452652017428 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452652017429 Walker A motif; other site 452652017430 ATP binding site [chemical binding]; other site 452652017431 Walker B motif; other site 452652017432 arginine finger; other site 452652017433 stage V sporulation protein K; Region: spore_V_K; TIGR02881 452652017434 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452652017435 Walker A motif; other site 452652017436 ATP binding site [chemical binding]; other site 452652017437 Walker B motif; other site 452652017438 arginine finger; other site 452652017439 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 452652017440 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 452652017441 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652017442 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452652017443 DNA binding residues [nucleotide binding] 452652017444 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 452652017445 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 452652017446 active site 452652017447 ATP binding site [chemical binding]; other site 452652017448 substrate binding site [chemical binding]; other site 452652017449 activation loop (A-loop); other site 452652017450 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 452652017451 active site 452652017452 nucleophile elbow; other site 452652017453 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 452652017454 OsmC-like protein; Region: OsmC; pfam02566 452652017455 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 452652017456 active site 452652017457 catalytic triad [active] 452652017458 calcium binding site [ion binding]; other site 452652017459 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 452652017460 nudix motif; other site 452652017461 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 452652017462 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 452652017463 active site 452652017464 homodimer interface [polypeptide binding]; other site 452652017465 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 452652017466 DNA binding site [nucleotide binding] 452652017467 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 452652017468 AAA ATPase domain; Region: AAA_16; pfam13191 452652017469 Walker A motif; other site 452652017470 ATP binding site [chemical binding]; other site 452652017471 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452652017472 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452652017473 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 452652017474 active site 452652017475 catalytic site [active] 452652017476 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 452652017477 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 452652017478 active site 452652017479 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 452652017480 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 452652017481 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 452652017482 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 452652017483 Ligand binding site; other site 452652017484 Putative Catalytic site; other site 452652017485 DXD motif; other site 452652017486 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 452652017487 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 452652017488 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 452652017489 Ligand Binding Site [chemical binding]; other site 452652017490 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 452652017491 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 452652017492 NlpC/P60 family; Region: NLPC_P60; pfam00877 452652017493 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 452652017494 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 452652017495 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 452652017496 active site 452652017497 catalytic triad [active] 452652017498 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 452652017499 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 452652017500 Family description; Region: VCBS; pfam13517 452652017501 Family description; Region: VCBS; pfam13517 452652017502 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 452652017503 AAA ATPase domain; Region: AAA_16; pfam13191 452652017504 Helix-turn-helix domain; Region: HTH_18; pfam12833 452652017505 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 452652017506 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652017507 non-specific DNA binding site [nucleotide binding]; other site 452652017508 salt bridge; other site 452652017509 sequence-specific DNA binding site [nucleotide binding]; other site 452652017510 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 452652017511 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 452652017512 putative active site [active] 452652017513 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652017514 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 452652017515 non-specific DNA binding site [nucleotide binding]; other site 452652017516 salt bridge; other site 452652017517 sequence-specific DNA binding site [nucleotide binding]; other site 452652017518 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 452652017519 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 452652017520 DDE superfamily endonuclease; Region: DDE_4; cl17710 452652017521 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 452652017522 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 452652017523 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 452652017524 active site 452652017525 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 452652017526 non-prolyl cis peptide bond; other site 452652017527 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 452652017528 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 452652017529 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452652017530 Coenzyme A binding pocket [chemical binding]; other site 452652017531 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 452652017532 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 452652017533 dimer interface [polypeptide binding]; other site 452652017534 active site 452652017535 non-prolyl cis peptide bond; other site 452652017536 insertion regions; other site 452652017537 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 452652017538 endoglucanase; Region: PLN02308 452652017539 Cellulose binding domain; Region: CBM_3; smart01067 452652017540 Cellulose binding domain; Region: CBM_2; pfam00553 452652017541 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 452652017542 substrate binding pocket [chemical binding]; other site 452652017543 substrate-Mg2+ binding site; other site 452652017544 aspartate-rich region 1; other site 452652017545 aspartate-rich region 2; other site 452652017546 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652017547 S-adenosylmethionine binding site [chemical binding]; other site 452652017548 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 452652017549 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652017550 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452652017551 DNA binding residues [nucleotide binding] 452652017552 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 452652017553 metal-binding site [ion binding] 452652017554 Tubulin like; Region: Tubulin_2; pfam13809 452652017555 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 452652017556 metal ion-dependent adhesion site (MIDAS); other site 452652017557 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 452652017558 cyclase homology domain; Region: CHD; cd07302 452652017559 dimer interface [polypeptide binding]; other site 452652017560 nucleotidyl binding site; other site 452652017561 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 452652017562 metal binding site [ion binding]; metal-binding site 452652017563 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 452652017564 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 452652017565 ligand binding site [chemical binding]; other site 452652017566 flexible hinge region; other site 452652017567 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 452652017568 RibD C-terminal domain; Region: RibD_C; cl17279 452652017569 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 452652017570 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 452652017571 active site 452652017572 catalytic triad [active] 452652017573 oxyanion hole [active] 452652017574 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 452652017575 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 452652017576 NAD(P) binding site [chemical binding]; other site 452652017577 Condensation domain; Region: Condensation; pfam00668 452652017578 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 452652017579 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 452652017580 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452652017581 acyl-activating enzyme (AAE) consensus motif; other site 452652017582 AMP binding site [chemical binding]; other site 452652017583 active site 452652017584 CoA binding site [chemical binding]; other site 452652017585 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 452652017586 O-methyltransferase; Region: Methyltransf_2; pfam00891 452652017587 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 452652017588 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 452652017589 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 452652017590 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 452652017591 phosphate binding site [ion binding]; other site 452652017592 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 452652017593 Cytochrome P450; Region: p450; cl12078 452652017594 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 452652017595 Cytochrome P450; Region: p450; cl12078 452652017596 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 452652017597 tetramerization interface [polypeptide binding]; other site 452652017598 active site 452652017599 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652017600 S-adenosylmethionine binding site [chemical binding]; other site 452652017601 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 452652017602 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 452652017603 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 452652017604 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 452652017605 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652017606 putative substrate translocation pore; other site 452652017607 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 452652017608 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 452652017609 Actin-Fragmin Kinase (AFK); catalytic domain. The AFK catalytic domain is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, aminoglycoside...; Region: AFK; cl07713 452652017610 ATP binding site [chemical binding]; other site 452652017611 biosynthesis cluster domain; Region: biosyn_clust_1; TIGR04098 452652017612 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 452652017613 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 452652017614 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 452652017615 active site 452652017616 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652017617 NAD(P) binding site [chemical binding]; other site 452652017618 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 452652017619 active site 452652017620 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 452652017621 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 452652017622 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 452652017623 active site 452652017624 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 452652017625 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 452652017626 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 452652017627 putative NADP binding site [chemical binding]; other site 452652017628 active site 452652017629 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 452652017630 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 452652017631 active site 452652017632 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 452652017633 putative NADP binding site [chemical binding]; other site 452652017634 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 452652017635 active site 452652017636 Methyltransferase domain; Region: Methyltransf_12; pfam08242 452652017637 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 452652017638 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 452652017639 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 452652017640 active site 452652017641 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 452652017642 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 452652017643 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 452652017644 active site 452652017645 Condensation domain; Region: Condensation; pfam00668 452652017646 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 452652017647 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 452652017648 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 452652017649 acyl-activating enzyme (AAE) consensus motif; other site 452652017650 AMP binding site [chemical binding]; other site 452652017651 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 452652017652 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 452652017653 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 452652017654 active site 452652017655 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 452652017656 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 452652017657 putative NADP binding site [chemical binding]; other site 452652017658 KR domain; Region: KR; pfam08659 452652017659 active site 452652017660 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 452652017661 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 452652017662 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 452652017663 active site 452652017664 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 452652017665 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 452652017666 putative NADP binding site [chemical binding]; other site 452652017667 active site 452652017668 Methyltransferase domain; Region: Methyltransf_23; pfam13489 452652017669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652017670 S-adenosylmethionine binding site [chemical binding]; other site 452652017671 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 452652017672 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 452652017673 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 452652017674 active site 452652017675 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 452652017676 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 452652017677 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 452652017678 active site 452652017679 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 452652017680 putative NADP binding site [chemical binding]; other site 452652017681 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 452652017682 active site 452652017683 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 452652017684 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 452652017685 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 452652017686 active site 452652017687 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 452652017688 putative NADP binding site [chemical binding]; other site 452652017689 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 452652017690 active site 452652017691 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 452652017692 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 452652017693 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 452652017694 active site 452652017695 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 452652017696 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 452652017697 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 452652017698 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 452652017699 putative NADP binding site [chemical binding]; other site 452652017700 active site 452652017701 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 452652017702 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 452652017703 active site 452652017704 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 452652017705 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 452652017706 putative NADP binding site [chemical binding]; other site 452652017707 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 452652017708 active site 452652017709 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 452652017710 Erythronolide synthase docking; Region: Docking; pfam08990 452652017711 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 452652017712 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 452652017713 active site 452652017714 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 452652017715 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 452652017716 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 452652017717 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 452652017718 putative NADP binding site [chemical binding]; other site 452652017719 active site 452652017720 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 452652017721 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 452652017722 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 452652017723 active site 452652017724 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 452652017725 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 452652017726 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 452652017727 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 452652017728 Cytochrome P450; Region: p450; cl12078 452652017729 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 452652017730 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 452652017731 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 452652017732 Glutamine amidotransferase class-I; Region: GATase; pfam00117 452652017733 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 452652017734 glutamine binding [chemical binding]; other site 452652017735 catalytic triad [active] 452652017736 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 452652017737 DNA-binding site [nucleotide binding]; DNA binding site 452652017738 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 452652017739 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 452652017740 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652017741 homodimer interface [polypeptide binding]; other site 452652017742 catalytic residue [active] 452652017743 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 452652017744 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 452652017745 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 452652017746 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 452652017747 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652017748 salt bridge; other site 452652017749 non-specific DNA binding site [nucleotide binding]; other site 452652017750 sequence-specific DNA binding site [nucleotide binding]; other site 452652017751 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 452652017752 putative active site [active] 452652017753 putative catalytic site [active] 452652017754 putative DNA binding site [nucleotide binding]; other site 452652017755 putative phosphate binding site [ion binding]; other site 452652017756 metal binding site A [ion binding]; metal-binding site 452652017757 putative AP binding site [nucleotide binding]; other site 452652017758 putative metal binding site B [ion binding]; other site 452652017759 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 452652017760 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 452652017761 DNA-binding site [nucleotide binding]; DNA binding site 452652017762 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 452652017763 Predicted esterase [General function prediction only]; Region: COG0400 452652017764 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 452652017765 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 452652017766 nucleotide binding site [chemical binding]; other site 452652017767 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 452652017768 Predicted methyltransferase [General function prediction only]; Region: COG3897 452652017769 putative acetyltransferase; Provisional; Region: PRK03624 452652017770 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452652017771 Coenzyme A binding pocket [chemical binding]; other site 452652017772 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 452652017773 Sulfatase; Region: Sulfatase; pfam00884 452652017774 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 452652017775 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 452652017776 Walker A/P-loop; other site 452652017777 ATP binding site [chemical binding]; other site 452652017778 Q-loop/lid; other site 452652017779 ABC transporter signature motif; other site 452652017780 Walker B; other site 452652017781 D-loop; other site 452652017782 H-loop/switch region; other site 452652017783 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 452652017784 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 452652017785 Walker A/P-loop; other site 452652017786 ATP binding site [chemical binding]; other site 452652017787 Q-loop/lid; other site 452652017788 ABC transporter signature motif; other site 452652017789 Walker B; other site 452652017790 D-loop; other site 452652017791 H-loop/switch region; other site 452652017792 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 452652017793 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 452652017794 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652017795 dimer interface [polypeptide binding]; other site 452652017796 conserved gate region; other site 452652017797 putative PBP binding loops; other site 452652017798 ABC-ATPase subunit interface; other site 452652017799 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 452652017800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 452652017801 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652017802 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 452652017803 ABC-ATPase subunit interface; other site 452652017804 putative PBP binding loops; other site 452652017805 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 452652017806 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 452652017807 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 452652017808 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 452652017809 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 452652017810 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 452652017811 active site 452652017812 iron coordination sites [ion binding]; other site 452652017813 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 452652017814 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652017815 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652017816 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 452652017817 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 452652017818 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 452652017819 catalytic residue [active] 452652017820 Methyltransferase domain; Region: Methyltransf_31; pfam13847 452652017821 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652017822 S-adenosylmethionine binding site [chemical binding]; other site 452652017823 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 452652017824 CAAX protease self-immunity; Region: Abi; pfam02517 452652017825 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 452652017826 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 452652017827 substrate binding site [chemical binding]; other site 452652017828 ATP binding site [chemical binding]; other site 452652017829 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 452652017830 Dienelactone hydrolase family; Region: DLH; pfam01738 452652017831 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 452652017832 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 452652017833 nucleotide binding pocket [chemical binding]; other site 452652017834 K-X-D-G motif; other site 452652017835 catalytic site [active] 452652017836 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 452652017837 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 452652017838 Dimer interface [polypeptide binding]; other site 452652017839 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 452652017840 metal ion-dependent adhesion site (MIDAS); other site 452652017841 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 452652017842 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 452652017843 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 452652017844 inhibitor-cofactor binding pocket; inhibition site 452652017845 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652017846 catalytic residue [active] 452652017847 biotin synthase; Validated; Region: PRK06256 452652017848 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 452652017849 FeS/SAM binding site; other site 452652017850 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 452652017851 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652017852 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 452652017853 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 452652017854 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652017855 putative substrate translocation pore; other site 452652017856 Rrf2 family protein; Region: rrf2_super; TIGR00738 452652017857 Transcriptional regulator; Region: Rrf2; pfam02082 452652017858 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 452652017859 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 452652017860 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 452652017861 dimerization interface [polypeptide binding]; other site 452652017862 putative DNA binding site [nucleotide binding]; other site 452652017863 putative Zn2+ binding site [ion binding]; other site 452652017864 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452652017865 Walker A motif; other site 452652017866 ATP binding site [chemical binding]; other site 452652017867 Walker B motif; other site 452652017868 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 452652017869 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 452652017870 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 452652017871 putative metal binding site [ion binding]; other site 452652017872 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 452652017873 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 452652017874 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 452652017875 sugar binding site [chemical binding]; other site 452652017876 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 452652017877 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 452652017878 sugar binding site [chemical binding]; other site 452652017879 Phosphotransferase enzyme family; Region: APH; pfam01636 452652017880 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 452652017881 active site 452652017882 substrate binding site [chemical binding]; other site 452652017883 ATP binding site [chemical binding]; other site 452652017884 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 452652017885 putative Zn2+ binding site [ion binding]; other site 452652017886 putative DNA binding site [nucleotide binding]; other site 452652017887 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 452652017888 6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254 452652017889 putative NAD(P) binding site [chemical binding]; other site 452652017890 catalytic Zn binding site [ion binding]; other site 452652017891 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652017892 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cl17391 452652017893 Chloramphenicol (Cm) binding site [chemical binding]; other site 452652017894 catalytic residue [active] 452652017895 ATP binding site [chemical binding]; other site 452652017896 short chain dehydrogenase; Provisional; Region: PRK06172 452652017897 classical (c) SDRs; Region: SDR_c; cd05233 452652017898 NAD(P) binding site [chemical binding]; other site 452652017899 active site 452652017900 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652017901 salt bridge; other site 452652017902 non-specific DNA binding site [nucleotide binding]; other site 452652017903 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 452652017904 sequence-specific DNA binding site [nucleotide binding]; other site 452652017905 SnoaL-like domain; Region: SnoaL_2; pfam12680 452652017906 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 452652017907 ATP binding site [chemical binding]; other site 452652017908 putative Mg++ binding site [ion binding]; other site 452652017909 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 452652017910 nucleotide binding region [chemical binding]; other site 452652017911 ATP-binding site [chemical binding]; other site 452652017912 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 452652017913 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 452652017914 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 452652017915 dimer interface [polypeptide binding]; other site 452652017916 active site 452652017917 CoA binding pocket [chemical binding]; other site 452652017918 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 452652017919 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652017920 salt bridge; other site 452652017921 non-specific DNA binding site [nucleotide binding]; other site 452652017922 sequence-specific DNA binding site [nucleotide binding]; other site 452652017923 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 452652017924 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652017925 NAD(P) binding site [chemical binding]; other site 452652017926 active site 452652017927 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 452652017928 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652017929 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652017930 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 452652017931 active site 452652017932 F420-dependent oxidoreductase, CPS_4043 family; Region: F420_CPS_4043; TIGR03842 452652017933 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 452652017934 putative metal binding site [ion binding]; other site 452652017935 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 452652017936 ADP-ribose binding site [chemical binding]; other site 452652017937 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 452652017938 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652017939 non-specific DNA binding site [nucleotide binding]; other site 452652017940 salt bridge; other site 452652017941 sequence-specific DNA binding site [nucleotide binding]; other site 452652017942 Cupin domain; Region: Cupin_2; pfam07883 452652017943 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652017944 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 452652017945 active site 452652017946 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 452652017947 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 452652017948 putative sugar binding sites [chemical binding]; other site 452652017949 Q-X-W motif; other site 452652017950 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 452652017951 active site 452652017952 Ricin-type beta-trefoil; Region: RICIN; smart00458 452652017953 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 452652017954 putative sugar binding sites [chemical binding]; other site 452652017955 Q-X-W motif; other site 452652017956 Cupin domain; Region: Cupin_2; cl17218 452652017957 Domain of unknown function (DUF385); Region: DUF385; cl04387 452652017958 Hemerythrin-like domain; Region: Hr-like; cd12108 452652017959 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 452652017960 MarR family; Region: MarR_2; pfam12802 452652017961 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 452652017962 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 452652017963 Methyltransferase domain; Region: Methyltransf_23; pfam13489 452652017964 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652017965 S-adenosylmethionine binding site [chemical binding]; other site 452652017966 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 452652017967 active site residue [active] 452652017968 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 452652017969 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 452652017970 dimerization interface [polypeptide binding]; other site 452652017971 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 452652017972 rRNA binding site [nucleotide binding]; other site 452652017973 predicted 30S ribosome binding site; other site 452652017974 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 452652017975 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 452652017976 motif II; other site 452652017977 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 452652017978 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 452652017979 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 452652017980 catalytic residue [active] 452652017981 Uncharacterized conserved protein [Function unknown]; Region: COG3379 452652017982 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 452652017983 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 452652017984 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 452652017985 DNA-binding site [nucleotide binding]; DNA binding site 452652017986 UTRA domain; Region: UTRA; pfam07702 452652017987 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 452652017988 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 452652017989 putative NAD(P) binding site [chemical binding]; other site 452652017990 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 452652017991 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652017992 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 452652017993 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 452652017994 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 452652017995 DNA binding residues [nucleotide binding] 452652017996 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 452652017997 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 452652017998 Sulfatase; Region: Sulfatase; pfam00884 452652017999 Uncharacterized conserved protein [Function unknown]; Region: COG1262 452652018000 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 452652018001 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 452652018002 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 452652018003 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 452652018004 active site 452652018005 Zn binding site [ion binding]; other site 452652018006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452652018007 Walker A motif; other site 452652018008 ATP binding site [chemical binding]; other site 452652018009 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652018010 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652018011 DNA binding residues [nucleotide binding] 452652018012 dimerization interface [polypeptide binding]; other site 452652018013 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 452652018014 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 452652018015 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 452652018016 active site 452652018017 Zn binding site [ion binding]; other site 452652018018 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 452652018019 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 452652018020 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 452652018021 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 452652018022 dimerization interface [polypeptide binding]; other site 452652018023 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 452652018024 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 452652018025 putative Iron-sulfur protein interface [polypeptide binding]; other site 452652018026 proximal heme binding site [chemical binding]; other site 452652018027 distal heme binding site [chemical binding]; other site 452652018028 putative dimer interface [polypeptide binding]; other site 452652018029 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 452652018030 L-aspartate oxidase; Provisional; Region: PRK06175 452652018031 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 452652018032 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 452652018033 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 452652018034 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 452652018035 Uncharacterized conserved protein [Function unknown]; Region: COG1359 452652018036 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 452652018037 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 452652018038 DNA binding residues [nucleotide binding] 452652018039 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 452652018040 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 452652018041 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 452652018042 putative DNA binding site [nucleotide binding]; other site 452652018043 putative Zn2+ binding site [ion binding]; other site 452652018044 AsnC family; Region: AsnC_trans_reg; pfam01037 452652018045 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652018046 putative substrate translocation pore; other site 452652018047 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 452652018048 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 452652018049 Beta-lactamase; Region: Beta-lactamase; pfam00144 452652018050 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 452652018051 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 452652018052 DNA-binding site [nucleotide binding]; DNA binding site 452652018053 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652018054 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652018055 hypothetical protein; Provisional; Region: PRK07236 452652018056 hypothetical protein; Provisional; Region: PRK07588 452652018057 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 452652018058 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 452652018059 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 452652018060 active site 452652018061 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 452652018062 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 452652018063 NAD(P) binding site [chemical binding]; other site 452652018064 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 452652018065 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 452652018066 substrate-cofactor binding pocket; other site 452652018067 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652018068 catalytic residue [active] 452652018069 Transcriptional regulator [Transcription]; Region: LysR; COG0583 452652018070 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 452652018071 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 452652018072 putative dimerization interface [polypeptide binding]; other site 452652018073 TAP-like protein; Region: Abhydrolase_4; pfam08386 452652018074 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 452652018075 putative catalytic site [active] 452652018076 putative phosphate binding site [ion binding]; other site 452652018077 putative metal binding site [ion binding]; other site 452652018078 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 452652018079 Fic/DOC family; Region: Fic; cl00960 452652018080 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 452652018081 putative sugar binding site [chemical binding]; other site 452652018082 catalytic residues [active] 452652018083 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 452652018084 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 452652018085 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14178 452652018086 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 452652018087 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 452652018088 homodimer interface [polypeptide binding]; other site 452652018089 NADP binding site [chemical binding]; other site 452652018090 substrate binding site [chemical binding]; other site 452652018091 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 452652018092 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 452652018093 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652018094 NAD(P) binding site [chemical binding]; other site 452652018095 active site 452652018096 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652018097 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652018098 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 452652018099 active site 452652018100 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 452652018101 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 452652018102 motif II; other site 452652018103 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 452652018104 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 452652018105 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 452652018106 Protein of unknown function (DUF4101); Region: DUF4101; pfam13355 452652018107 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 452652018108 ATP-grasp domain; Region: ATP-grasp_4; cl17255 452652018109 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 452652018110 DDE superfamily endonuclease; Region: DDE_5; pfam13546 452652018111 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 452652018112 carboxyltransferase (CT) interaction site; other site 452652018113 biotinylation site [posttranslational modification]; other site 452652018114 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 452652018115 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 452652018116 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 452652018117 active site 452652018118 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 452652018119 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 452652018120 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 452652018121 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 452652018122 active site 452652018123 4-coumarate--CoA ligase; Region: PLN02246 452652018124 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452652018125 acyl-activating enzyme (AAE) consensus motif; other site 452652018126 AMP binding site [chemical binding]; other site 452652018127 active site 452652018128 CoA binding site [chemical binding]; other site 452652018129 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652018130 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652018131 PAS domain S-box; Region: sensory_box; TIGR00229 452652018132 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452652018133 putative active site [active] 452652018134 heme pocket [chemical binding]; other site 452652018135 PAS fold; Region: PAS_4; pfam08448 452652018136 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452652018137 putative active site [active] 452652018138 heme pocket [chemical binding]; other site 452652018139 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 452652018140 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 452652018141 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 452652018142 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 452652018143 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 452652018144 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652018145 putative substrate translocation pore; other site 452652018146 hypothetical protein; Provisional; Region: PRK07236 452652018147 FAD binding domain; Region: FAD_binding_3; pfam01494 452652018148 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 452652018149 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 452652018150 SchA/CurD like domain; Region: SchA_CurD; pfam04486 452652018151 Cupin domain; Region: Cupin_2; pfam07883 452652018152 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 452652018153 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 452652018154 dimer interface [polypeptide binding]; other site 452652018155 active site 452652018156 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 452652018157 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 452652018158 active site 452652018159 N-terminal aromatase/cyclase domain of the multifunctional protein tetracenomycin (TcmN) and related domains; Region: TcmN_ARO-CYC_like; cd08860 452652018160 putative hydrophobic ligand binding site [chemical binding]; other site 452652018161 active site 452652018162 catalytic residues_2 [active] 452652018163 catalytic residues_1 [active] 452652018164 Polyketide synthesis cyclase; Region: Cyclase_polyket; pfam04673 452652018165 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 452652018166 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 452652018167 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 452652018168 carboxyltransferase (CT) interaction site; other site 452652018169 biotinylation site [posttranslational modification]; other site 452652018170 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 452652018171 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 452652018172 ATP-grasp domain; Region: ATP-grasp_4; cl17255 452652018173 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 452652018174 O-methyltransferase; Region: Methyltransf_2; pfam00891 452652018175 Right handed beta helix region; Region: Beta_helix; pfam13229 452652018176 Predicted membrane protein [Function unknown]; Region: COG4425 452652018177 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 452652018178 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 452652018179 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652018180 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652018181 Protein of unknown function (DUF552); Region: DUF552; pfam04472 452652018182 Protein of unknown function (DUF664); Region: DUF664; pfam04978 452652018183 Uncharacterized conserved protein [Function unknown]; Region: COG0398 452652018184 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 452652018185 AP endonuclease family 2; Region: AP2Ec; smart00518 452652018186 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 452652018187 AP (apurinic/apyrimidinic) site pocket; other site 452652018188 DNA interaction; other site 452652018189 Metal-binding active site; metal-binding site 452652018190 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652018191 S-adenosylmethionine binding site [chemical binding]; other site 452652018192 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652018193 putative substrate translocation pore; other site 452652018194 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 452652018195 putative DNA binding site [nucleotide binding]; other site 452652018196 dimerization interface [polypeptide binding]; other site 452652018197 putative Zn2+ binding site [ion binding]; other site 452652018198 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 452652018199 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 452652018200 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 452652018201 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 452652018202 DNA binding residues [nucleotide binding] 452652018203 TOBE domain; Region: TOBE; cl01440 452652018204 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 452652018205 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 452652018206 active site 452652018207 catalytic site [active] 452652018208 metal binding site [ion binding]; metal-binding site 452652018209 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 452652018210 Domain of unknown function DUF20; Region: UPF0118; pfam01594 452652018211 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 452652018212 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 452652018213 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 452652018214 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 452652018215 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452652018216 Coenzyme A binding pocket [chemical binding]; other site 452652018217 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 452652018218 metal-binding site [ion binding] 452652018219 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 452652018220 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 452652018221 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 452652018222 Predicted amidohydrolase [General function prediction only]; Region: COG0388 452652018223 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 452652018224 active site 452652018225 catalytic triad [active] 452652018226 dimer interface [polypeptide binding]; other site 452652018227 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652018228 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652018229 DNA binding residues [nucleotide binding] 452652018230 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 452652018231 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 452652018232 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 452652018233 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 452652018234 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 452652018235 homodimer interface [polypeptide binding]; other site 452652018236 substrate-cofactor binding pocket; other site 452652018237 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652018238 catalytic residue [active] 452652018239 Transcriptional regulator [Transcription]; Region: LysR; COG0583 452652018240 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 452652018241 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 452652018242 putative dimerization interface [polypeptide binding]; other site 452652018243 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 452652018244 EamA-like transporter family; Region: EamA; cl17759 452652018245 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 452652018246 NlpC/P60 family; Region: NLPC_P60; pfam00877 452652018247 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 452652018248 Phosphotransferase enzyme family; Region: APH; pfam01636 452652018249 active site 452652018250 substrate binding site [chemical binding]; other site 452652018251 ATP binding site [chemical binding]; other site 452652018252 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 452652018253 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 452652018254 EF-hand domain pair; Region: EF_hand_5; pfam13499 452652018255 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 452652018256 Ca2+ binding site [ion binding]; other site 452652018257 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 452652018258 EF-hand domain pair; Region: EF_hand_5; pfam13499 452652018259 Ca2+ binding site [ion binding]; other site 452652018260 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 452652018261 EF-hand domain pair; Region: EF_hand_5; pfam13499 452652018262 Ca2+ binding site [ion binding]; other site 452652018263 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452652018264 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 452652018265 FtsX-like permease family; Region: FtsX; pfam02687 452652018266 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 452652018267 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 452652018268 Walker A/P-loop; other site 452652018269 ATP binding site [chemical binding]; other site 452652018270 Q-loop/lid; other site 452652018271 ABC transporter signature motif; other site 452652018272 Walker B; other site 452652018273 D-loop; other site 452652018274 H-loop/switch region; other site 452652018275 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cl01268 452652018276 putative substrate binding pocket [chemical binding]; other site 452652018277 trimer interface [polypeptide binding]; other site 452652018278 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652018279 salt bridge; other site 452652018280 non-specific DNA binding site [nucleotide binding]; other site 452652018281 sequence-specific DNA binding site [nucleotide binding]; other site 452652018282 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652018283 non-specific DNA binding site [nucleotide binding]; other site 452652018284 salt bridge; other site 452652018285 sequence-specific DNA binding site [nucleotide binding]; other site 452652018286 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 452652018287 LytB protein; Region: LYTB; cl00507 452652018288 CHAT domain; Region: CHAT; pfam12770 452652018289 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166 452652018290 putative ligand binding site [chemical binding]; other site 452652018291 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 452652018292 putative NAD binding site [chemical binding]; other site 452652018293 catalytic site [active] 452652018294 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652018295 S-adenosylmethionine binding site [chemical binding]; other site 452652018296 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 452652018297 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652018298 S-adenosylmethionine binding site [chemical binding]; other site 452652018299 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 452652018300 active site 452652018301 metal binding site [ion binding]; metal-binding site 452652018302 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652018303 NAD(P) binding site [chemical binding]; other site 452652018304 active site 452652018305 Predicted transcriptional regulators [Transcription]; Region: COG1733 452652018306 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 452652018307 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 452652018308 putative deacylase active site [active] 452652018309 methionine sulfoxide reductase A; Provisional; Region: PRK14054 452652018310 AAA domain; Region: AAA_33; pfam13671 452652018311 AAA domain; Region: AAA_17; pfam13207 452652018312 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652018313 WHG domain; Region: WHG; pfam13305 452652018314 FtsX-like permease family; Region: FtsX; pfam02687 452652018315 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452652018316 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452652018317 DNA binding residues [nucleotide binding] 452652018318 dimerization interface [polypeptide binding]; other site 452652018319 Methyltransferase domain; Region: Methyltransf_11; pfam08241 452652018320 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 452652018321 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652018322 NAD(P) binding site [chemical binding]; other site 452652018323 active site 452652018324 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652018325 Acyl transferase domain; Region: Acyl_transf_1; cl08282 452652018326 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 452652018327 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 452652018328 dimer interface [polypeptide binding]; other site 452652018329 active site 452652018330 CoA binding pocket [chemical binding]; other site 452652018331 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652018332 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 452652018333 NAD(P) binding site [chemical binding]; other site 452652018334 active site 452652018335 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 452652018336 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 452652018337 dimer interface [polypeptide binding]; other site 452652018338 active site 452652018339 CoA binding pocket [chemical binding]; other site 452652018340 acyl carrier protein; Provisional; Region: acpP; PRK00982 452652018341 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 452652018342 dimer interface [polypeptide binding]; other site 452652018343 active site 452652018344 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 452652018345 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 452652018346 DNA binding residues [nucleotide binding] 452652018347 Ferredoxin [Energy production and conversion]; Region: COG1146 452652018348 4Fe-4S binding domain; Region: Fer4; pfam00037 452652018349 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 452652018350 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 452652018351 acyl-activating enzyme (AAE) consensus motif; other site 452652018352 putative AMP binding site [chemical binding]; other site 452652018353 putative active site [active] 452652018354 putative CoA binding site [chemical binding]; other site 452652018355 acyl-CoA synthetase; Validated; Region: PRK06188 452652018356 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 452652018357 acyl-activating enzyme (AAE) consensus motif; other site 452652018358 AMP binding site [chemical binding]; other site 452652018359 active site 452652018360 CoA binding site [chemical binding]; other site 452652018361 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 452652018362 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 452652018363 substrate-cofactor binding pocket; other site 452652018364 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452652018365 catalytic residue [active] 452652018366 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 452652018367 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 452652018368 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 452652018369 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 452652018370 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 452652018371 active site 452652018372 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 452652018373 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 452652018374 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 452652018375 NADP binding site [chemical binding]; other site 452652018376 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 452652018377 active site 452652018378 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 452652018379 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 452652018380 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 452652018381 active site 452652018382 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 452652018383 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 452652018384 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 452652018385 NADP binding site [chemical binding]; other site 452652018386 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 452652018387 active site 452652018388 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 452652018389 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 452652018390 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 452652018391 active site 452652018392 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 452652018393 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 452652018394 Erythronolide synthase docking; Region: Docking; pfam08990 452652018395 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 452652018396 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 452652018397 active site 452652018398 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 452652018399 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 452652018400 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 452652018401 NADP binding site [chemical binding]; other site 452652018402 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 452652018403 active site 452652018404 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 452652018405 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 452652018406 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 452652018407 active site 452652018408 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 452652018409 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 452652018410 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 452652018411 NADP binding site [chemical binding]; other site 452652018412 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 452652018413 active site 452652018414 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 452652018415 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 452652018416 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 452652018417 active site 452652018418 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 452652018419 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 452652018420 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 452652018421 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 452652018422 putative NADP binding site [chemical binding]; other site 452652018423 active site 452652018424 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 452652018425 Erythronolide synthase docking; Region: Docking; pfam08990 452652018426 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 452652018427 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 452652018428 active site 452652018429 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 452652018430 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 452652018431 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 452652018432 putative NADP binding site [chemical binding]; other site 452652018433 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 452652018434 active site 452652018435 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 452652018436 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 452652018437 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 452652018438 active site 452652018439 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 452652018440 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 452652018441 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652018442 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 452652018443 Enoylreductase; Region: PKS_ER; smart00829 452652018444 NAD(P) binding site [chemical binding]; other site 452652018445 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 452652018446 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 452652018447 putative NADP binding site [chemical binding]; other site 452652018448 active site 452652018449 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 452652018450 Erythronolide synthase docking; Region: Docking; pfam08990 452652018451 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 452652018452 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 452652018453 active site 452652018454 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 452652018455 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 452652018456 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 452652018457 NADP binding site [chemical binding]; other site 452652018458 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 452652018459 active site 452652018460 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 452652018461 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 452652018462 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 452652018463 active site 452652018464 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 452652018465 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 452652018466 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 452652018467 putative NADP binding site [chemical binding]; other site 452652018468 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 452652018469 active site 452652018470 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 452652018471 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 452652018472 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 452652018473 active site 452652018474 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 452652018475 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 452652018476 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652018477 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 452652018478 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 452652018479 putative NADP binding site [chemical binding]; other site 452652018480 active site 452652018481 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 452652018482 Thioesterase; Region: PKS_TE; smart00824 452652018483 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 452652018484 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 452652018485 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 452652018486 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 452652018487 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 452652018488 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 452652018489 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 452652018490 active site 452652018491 FkbH-like domain; Region: FkbH; TIGR01686 452652018492 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 452652018493 active site 452652018494 motif I; other site 452652018495 motif II; other site 452652018496 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 452652018497 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 452652018498 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 452652018499 DNA binding site [nucleotide binding] 452652018500 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 452652018501 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 452652018502 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 452652018503 Acyl transferase domain; Region: Acyl_transf_1; cl08282 452652018504 Acyl transferase domain; Region: Acyl_transf_1; cl08282 452652018505 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 452652018506 AMP-binding enzyme; Region: AMP-binding; pfam00501 452652018507 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 452652018508 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 452652018509 catalytic residue [active] 452652018510 putative FPP diphosphate binding site; other site 452652018511 putative FPP binding hydrophobic cleft; other site 452652018512 dimer interface [polypeptide binding]; other site 452652018513 putative IPP diphosphate binding site; other site 452652018514 Predicted transcriptional regulators [Transcription]; Region: COG1695 452652018515 Transcriptional regulator PadR-like family; Region: PadR; cl17335 452652018516 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 452652018517 hypothetical protein; Provisional; Region: PRK08317 452652018518 Methyltransferase domain; Region: Methyltransf_11; pfam08241 452652018519 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 452652018520 heme binding pocket [chemical binding]; other site 452652018521 heme ligand [chemical binding]; other site 452652018522 Htaa; Region: HtaA; pfam04213 452652018523 Htaa; Region: HtaA; pfam04213 452652018524 Htaa; Region: HtaA; pfam04213 452652018525 Htaa; Region: HtaA; pfam04213 452652018526 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 452652018527 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 452652018528 intersubunit interface [polypeptide binding]; other site 452652018529 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 452652018530 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 452652018531 ABC-ATPase subunit interface; other site 452652018532 dimer interface [polypeptide binding]; other site 452652018533 putative PBP binding regions; other site 452652018534 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 452652018535 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 452652018536 Walker A/P-loop; other site 452652018537 ATP binding site [chemical binding]; other site 452652018538 Q-loop/lid; other site 452652018539 ABC transporter signature motif; other site 452652018540 Walker B; other site 452652018541 D-loop; other site 452652018542 H-loop/switch region; other site 452652018543 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 452652018544 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 452652018545 dimerization interface [polypeptide binding]; other site 452652018546 putative DNA binding site [nucleotide binding]; other site 452652018547 putative Zn2+ binding site [ion binding]; other site 452652018548 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 452652018549 active site residue [active] 452652018550 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 452652018551 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 452652018552 putative NAD(P) binding site [chemical binding]; other site 452652018553 Cupin; Region: Cupin_6; pfam12852 452652018554 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 452652018555 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452652018556 K+ potassium transporter; Region: K_trans; cl15781 452652018557 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 452652018558 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 452652018559 inhibitor binding site; inhibition site 452652018560 active site 452652018561 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 452652018562 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 452652018563 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 452652018564 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652018565 dimer interface [polypeptide binding]; other site 452652018566 conserved gate region; other site 452652018567 putative PBP binding loops; other site 452652018568 ABC-ATPase subunit interface; other site 452652018569 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 452652018570 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652018571 dimer interface [polypeptide binding]; other site 452652018572 conserved gate region; other site 452652018573 putative PBP binding loops; other site 452652018574 ABC-ATPase subunit interface; other site 452652018575 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 452652018576 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 452652018577 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 452652018578 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 452652018579 substrate binding site [chemical binding]; other site 452652018580 active site 452652018581 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 452652018582 metal binding site [ion binding]; metal-binding site 452652018583 ligand binding site [chemical binding]; other site 452652018584 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 452652018585 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 452652018586 Transcriptional regulators [Transcription]; Region: PurR; COG1609 452652018587 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 452652018588 DNA binding site [nucleotide binding] 452652018589 domain linker motif; other site 452652018590 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 452652018591 ligand binding site [chemical binding]; other site 452652018592 dimerization interface (open form) [polypeptide binding]; other site 452652018593 dimerization interface (closed form) [polypeptide binding]; other site 452652018594 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 452652018595 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 452652018596 putative ligand binding site [chemical binding]; other site 452652018597 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 452652018598 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 452652018599 Walker A/P-loop; other site 452652018600 ATP binding site [chemical binding]; other site 452652018601 Q-loop/lid; other site 452652018602 ABC transporter signature motif; other site 452652018603 Walker B; other site 452652018604 D-loop; other site 452652018605 H-loop/switch region; other site 452652018606 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 452652018607 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 452652018608 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 452652018609 TM-ABC transporter signature motif; other site 452652018610 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 452652018611 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 452652018612 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 452652018613 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 452652018614 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 452652018615 putative sugar binding sites [chemical binding]; other site 452652018616 Q-X-W motif; other site 452652018617 Glycosyl hydrolase family 62, characterized arabinofuranosidases; Region: GH62; cd08987 452652018618 active site 452652018619 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 452652018620 Ricin-type beta-trefoil; Region: RICIN; smart00458 452652018621 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 452652018622 putative sugar binding sites [chemical binding]; other site 452652018623 Q-X-W motif; other site 452652018624 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 452652018625 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 452652018626 Ricin-type beta-trefoil; Region: RICIN; smart00458 452652018627 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 452652018628 putative sugar binding sites [chemical binding]; other site 452652018629 Q-X-W motif; other site 452652018630 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 452652018631 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 452652018632 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 452652018633 Cellulose binding domain; Region: CBM_2; pfam00553 452652018634 Transcriptional regulator [Transcription]; Region: IclR; COG1414 452652018635 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 452652018636 Bacterial transcriptional regulator; Region: IclR; pfam01614 452652018637 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 452652018638 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 452652018639 iron-sulfur cluster [ion binding]; other site 452652018640 [2Fe-2S] cluster binding site [ion binding]; other site 452652018641 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 452652018642 hydrophobic ligand binding site; other site 452652018643 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 452652018644 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 452652018645 FMN-binding pocket [chemical binding]; other site 452652018646 flavin binding motif; other site 452652018647 phosphate binding motif [ion binding]; other site 452652018648 beta-alpha-beta structure motif; other site 452652018649 NAD binding pocket [chemical binding]; other site 452652018650 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 452652018651 catalytic loop [active] 452652018652 iron binding site [ion binding]; other site 452652018653 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 452652018654 putative Zn2+ binding site [ion binding]; other site 452652018655 putative DNA binding site [nucleotide binding]; other site 452652018656 dimerization interface [polypeptide binding]; other site 452652018657 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 452652018658 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 452652018659 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652018660 NAD(P) binding site [chemical binding]; other site 452652018661 active site 452652018662 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 452652018663 active site 452652018664 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 452652018665 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452652018666 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 452652018667 acyl-activating enzyme (AAE) consensus motif; other site 452652018668 acyl-activating enzyme (AAE) consensus motif; other site 452652018669 putative AMP binding site [chemical binding]; other site 452652018670 putative active site [active] 452652018671 putative CoA binding site [chemical binding]; other site 452652018672 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 452652018673 putative active site [active] 452652018674 putative catalytic site [active] 452652018675 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 452652018676 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 452652018677 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 452652018678 putative dimer interface [polypeptide binding]; other site 452652018679 Transcriptional regulators [Transcription]; Region: PurR; COG1609 452652018680 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 452652018681 DNA binding site [nucleotide binding] 452652018682 domain linker motif; other site 452652018683 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 452652018684 ligand binding site [chemical binding]; other site 452652018685 dimerization interface (open form) [polypeptide binding]; other site 452652018686 dimerization interface (closed form) [polypeptide binding]; other site 452652018687 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 452652018688 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 452652018689 putative ligand binding site [chemical binding]; other site 452652018690 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 452652018691 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 452652018692 Walker A/P-loop; other site 452652018693 ATP binding site [chemical binding]; other site 452652018694 Q-loop/lid; other site 452652018695 ABC transporter signature motif; other site 452652018696 Walker B; other site 452652018697 D-loop; other site 452652018698 H-loop/switch region; other site 452652018699 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 452652018700 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 452652018701 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 452652018702 TM-ABC transporter signature motif; other site 452652018703 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 452652018704 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 452652018705 TM-ABC transporter signature motif; other site 452652018706 ribulokinase; Provisional; Region: PRK04123 452652018707 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 452652018708 nucleotide binding site [chemical binding]; other site 452652018709 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 452652018710 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 452652018711 intersubunit interface [polypeptide binding]; other site 452652018712 active site 452652018713 Zn2+ binding site [ion binding]; other site 452652018714 L-arabinose isomerase; Provisional; Region: PRK02929 452652018715 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 452652018716 hexamer (dimer of trimers) interface [polypeptide binding]; other site 452652018717 trimer interface [polypeptide binding]; other site 452652018718 substrate binding site [chemical binding]; other site 452652018719 Mn binding site [ion binding]; other site 452652018720 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 452652018721 active site 452652018722 catalytic residues [active] 452652018723 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 452652018724 putative active site [active] 452652018725 catalytic residue [active] 452652018726 Phosphotransferase enzyme family; Region: APH; pfam01636 452652018727 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 452652018728 substrate binding site [chemical binding]; other site 452652018729 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 452652018730 aromatic chitin/cellulose binding site residues [chemical binding]; other site 452652018731 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 452652018732 Cellulose binding domain; Region: CBM_2; pfam00553 452652018733 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 452652018734 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 452652018735 putative DNA binding site [nucleotide binding]; other site 452652018736 putative Zn2+ binding site [ion binding]; other site 452652018737 AsnC family; Region: AsnC_trans_reg; pfam01037 452652018738 Cupin domain; Region: Cupin_2; cl17218 452652018739 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 452652018740 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 452652018741 Cytochrome P450; Region: p450; cl12078 452652018742 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 452652018743 dinuclear metal binding motif [ion binding]; other site 452652018744 Ferritin-like domain; Region: Ferritin_2; pfam13668 452652018745 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 452652018746 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652018747 S-adenosylmethionine binding site [chemical binding]; other site 452652018748 PGAP1-like protein; Region: PGAP1; pfam07819 452652018749 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 452652018750 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 452652018751 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 452652018752 ATP binding site [chemical binding]; other site 452652018753 Mg2+ binding site [ion binding]; other site 452652018754 G-X-G motif; other site 452652018755 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 452652018756 anti sigma factor interaction site; other site 452652018757 regulatory phosphorylation site [posttranslational modification]; other site 452652018758 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 452652018759 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 452652018760 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 452652018761 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652018762 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452652018763 DNA binding residues [nucleotide binding] 452652018764 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 452652018765 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 452652018766 DNA binding residues [nucleotide binding] 452652018767 B12 binding domain; Region: B12-binding_2; pfam02607 452652018768 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 452652018769 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 452652018770 active site 452652018771 catalytic site [active] 452652018772 substrate binding site [chemical binding]; other site 452652018773 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 452652018774 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 452652018775 GAF domain; Region: GAF; pfam01590 452652018776 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 452652018777 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 452652018778 Transcription factor WhiB; Region: Whib; pfam02467 452652018779 PRC-barrel domain; Region: PRC; pfam05239 452652018780 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 452652018781 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652018782 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 452652018783 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452652018784 DNA binding residues [nucleotide binding] 452652018785 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 452652018786 anti sigma factor interaction site; other site 452652018787 regulatory phosphorylation site [posttranslational modification]; other site 452652018788 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 452652018789 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 452652018790 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 452652018791 active site 452652018792 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 452652018793 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 452652018794 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 452652018795 Walker A/P-loop; other site 452652018796 ATP binding site [chemical binding]; other site 452652018797 Q-loop/lid; other site 452652018798 ABC transporter signature motif; other site 452652018799 Walker B; other site 452652018800 D-loop; other site 452652018801 H-loop/switch region; other site 452652018802 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 452652018803 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 452652018804 Walker A/P-loop; other site 452652018805 ATP binding site [chemical binding]; other site 452652018806 Q-loop/lid; other site 452652018807 ABC transporter signature motif; other site 452652018808 Walker B; other site 452652018809 D-loop; other site 452652018810 H-loop/switch region; other site 452652018811 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 452652018812 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 452652018813 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452652018814 dimer interface [polypeptide binding]; other site 452652018815 conserved gate region; other site 452652018816 ABC-ATPase subunit interface; other site 452652018817 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 452652018818 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 452652018819 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 452652018820 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 452652018821 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 452652018822 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 452652018823 PhoD-like phosphatase; Region: PhoD; pfam09423 452652018824 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 452652018825 putative active site [active] 452652018826 putative metal binding site [ion binding]; other site 452652018827 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 452652018828 Cupin domain; Region: Cupin_2; cl17218 452652018829 Aminoglycoside-2''-adenylyltransferase; Region: Aminoglyc_resit; pfam10706 452652018830 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 452652018831 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 452652018832 putative acyl-acceptor binding pocket; other site 452652018833 Protein of unknown function (DUF3087); Region: DUF3087; pfam11286 452652018834 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 452652018835 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 452652018836 Catalytic site [active] 452652018837 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 452652018838 active site 452652018839 Zn binding site [ion binding]; other site 452652018840 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 452652018841 Peptidase family M28; Region: Peptidase_M28; pfam04389 452652018842 active site 452652018843 metal binding site [ion binding]; metal-binding site 452652018844 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 452652018845 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 452652018846 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652018847 non-specific DNA binding site [nucleotide binding]; other site 452652018848 salt bridge; other site 452652018849 sequence-specific DNA binding site [nucleotide binding]; other site 452652018850 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 452652018851 putative active site [active] 452652018852 short chain dehydrogenase; Validated; Region: PRK06182 452652018853 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 452652018854 NADP binding site [chemical binding]; other site 452652018855 active site 452652018856 steroid binding site; other site 452652018857 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652018858 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652018859 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 452652018860 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 452652018861 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652018862 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 452652018863 SnoaL-like domain; Region: SnoaL_2; pfam12680 452652018864 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 452652018865 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 452652018866 MarR family; Region: MarR_2; pfam12802 452652018867 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652018868 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 452652018869 NAD(P) binding site [chemical binding]; other site 452652018870 active site 452652018871 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 452652018872 active site 452652018873 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 452652018874 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452652018875 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 452652018876 acyl-activating enzyme (AAE) consensus motif; other site 452652018877 acyl-activating enzyme (AAE) consensus motif; other site 452652018878 putative AMP binding site [chemical binding]; other site 452652018879 putative active site [active] 452652018880 putative CoA binding site [chemical binding]; other site 452652018881 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 452652018882 putative active site [active] 452652018883 putative catalytic site [active] 452652018884 TIGR03086 family protein; Region: TIGR03086 452652018885 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 452652018886 Predicted transcriptional regulators [Transcription]; Region: COG1733 452652018887 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 452652018888 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 452652018889 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652018890 NAD(P) binding site [chemical binding]; other site 452652018891 active site 452652018892 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652018893 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 452652018894 salt bridge; other site 452652018895 non-specific DNA binding site [nucleotide binding]; other site 452652018896 sequence-specific DNA binding site [nucleotide binding]; other site 452652018897 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 452652018898 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 452652018899 Peptidase inhibitor family I36; Region: Inhibitor_I36; pfam03995 452652018900 MG2 domain; Region: A2M_N; pfam01835 452652018901 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652018902 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652018903 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 452652018904 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 452652018905 short chain dehydrogenase; Provisional; Region: PRK06181 452652018906 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652018907 NAD(P) binding site [chemical binding]; other site 452652018908 active site 452652018909 MFS/sugar transport protein; Region: MFS_2; pfam13347 452652018910 PGAP1-like protein; Region: PGAP1; pfam07819 452652018911 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 452652018912 structural tetrad; other site 452652018913 FOG: WD40 repeat [General function prediction only]; Region: COG2319 452652018914 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 452652018915 structural tetrad; other site 452652018916 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 452652018917 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 452652018918 active site 452652018919 catalytic tetrad [active] 452652018920 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 452652018921 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 452652018922 protocatechuate 4,5-dioxygenase; Provisional; Region: pcmA; PRK13372 452652018923 The A subunit of Protocatechuate 4,5-dioxygenase (LigAB) is the smaller, non-catalytic subunit; Region: PCA_45_Doxase_A; cd07924 452652018924 tetramer interface [polypeptide binding]; other site 452652018925 dimer interface [polypeptide binding]; other site 452652018926 active site 452652018927 Subunit B of the Class III extradiol dioxygenase, Protocatechuate 4,5-dioxygenase, which catalyzes the oxidization and subsequent ring-opening of protocatechuate; Region: PCA_45_Dioxygenase_B; cd07364 452652018928 active site 452652018929 Fe(II) binding site [ion binding]; other site 452652018930 dimer interface [polypeptide binding]; other site 452652018931 tetramer interface [polypeptide binding]; other site 452652018932 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 452652018933 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 452652018934 active site 452652018935 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 452652018936 Amidohydrolase; Region: Amidohydro_2; pfam04909 452652018937 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 452652018938 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 452652018939 Transcriptional regulator [Transcription]; Region: IclR; COG1414 452652018940 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 452652018941 Bacterial transcriptional regulator; Region: IclR; pfam01614 452652018942 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 452652018943 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 452652018944 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 452652018945 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 452652018946 Cytochrome P450; Region: p450; cl12078 452652018947 short chain dehydrogenase; Provisional; Region: PRK07062 452652018948 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652018949 NAD(P) binding site [chemical binding]; other site 452652018950 active site 452652018951 benzoylformate decarboxylase; Reviewed; Region: PRK07092 452652018952 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 452652018953 PYR/PP interface [polypeptide binding]; other site 452652018954 dimer interface [polypeptide binding]; other site 452652018955 TPP binding site [chemical binding]; other site 452652018956 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 452652018957 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 452652018958 TPP-binding site [chemical binding]; other site 452652018959 dimer interface [polypeptide binding]; other site 452652018960 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 452652018961 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 452652018962 Cytochrome P450; Region: p450; cl12078 452652018963 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652018964 H+ Antiporter protein; Region: 2A0121; TIGR00900 452652018965 putative substrate translocation pore; other site 452652018966 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 452652018967 Zinc finger domain containing protein (CDGSH-type) [Function unknown]; Region: COG3369 452652018968 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 452652018969 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 452652018970 CDGSH-type zinc finger. Function unknown; Region: ZnF_CDGSH; smart00704 452652018971 Methyltransferase domain; Region: Methyltransf_31; pfam13847 452652018972 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652018973 S-adenosylmethionine binding site [chemical binding]; other site 452652018974 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 452652018975 substrate binding pocket [chemical binding]; other site 452652018976 substrate-Mg2+ binding site; other site 452652018977 aspartate-rich region 1; other site 452652018978 aspartate-rich region 2; other site 452652018979 Condensation domain; Region: Condensation; pfam00668 452652018980 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 452652018981 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 452652018982 acyl-activating enzyme (AAE) consensus motif; other site 452652018983 AMP binding site [chemical binding]; other site 452652018984 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 452652018985 Condensation domain; Region: Condensation; pfam00668 452652018986 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 452652018987 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 452652018988 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452652018989 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 452652018990 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 452652018991 acyl-activating enzyme (AAE) consensus motif; other site 452652018992 AMP binding site [chemical binding]; other site 452652018993 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 452652018994 thioester reductase domain; Region: Thioester-redct; TIGR01746 452652018995 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 452652018996 putative NAD(P) binding site [chemical binding]; other site 452652018997 active site 452652018998 putative substrate binding site [chemical binding]; other site 452652018999 Condensation domain; Region: Condensation; pfam00668 452652019000 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 452652019001 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 452652019002 acyl-activating enzyme (AAE) consensus motif; other site 452652019003 AMP binding site [chemical binding]; other site 452652019004 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 452652019005 Condensation domain; Region: Condensation; pfam00668 452652019006 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 452652019007 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 452652019008 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452652019009 acyl-activating enzyme (AAE) consensus motif; other site 452652019010 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 452652019011 AMP binding site [chemical binding]; other site 452652019012 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 452652019013 Condensation domain; Region: Condensation; pfam00668 452652019014 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 452652019015 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 452652019016 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 452652019017 acyl-activating enzyme (AAE) consensus motif; other site 452652019018 AMP binding site [chemical binding]; other site 452652019019 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 452652019020 Condensation domain; Region: Condensation; pfam00668 452652019021 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 452652019022 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 452652019023 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 452652019024 acyl-activating enzyme (AAE) consensus motif; other site 452652019025 AMP binding site [chemical binding]; other site 452652019026 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 452652019027 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 452652019028 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 452652019029 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 452652019030 MarR family; Region: MarR; pfam01047 452652019031 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652019032 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 452652019033 putative substrate translocation pore; other site 452652019034 ATP-grasp domain; Region: ATP-grasp_4; cl17255 452652019035 Major Facilitator Superfamily; Region: MFS_1; pfam07690 452652019036 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652019037 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 452652019038 Predicted transcriptional regulators [Transcription]; Region: COG1695 452652019039 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 452652019040 putative Zn2+ binding site [ion binding]; other site 452652019041 putative DNA binding site [nucleotide binding]; other site 452652019042 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 452652019043 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 452652019044 EF-hand domain pair; Region: EF_hand_5; pfam13499 452652019045 Ca2+ binding site [ion binding]; other site 452652019046 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 452652019047 active site 452652019048 oxyanion hole [active] 452652019049 catalytic triad [active] 452652019050 Integrase core domain; Region: rve_3; pfam13683 452652019051 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452652019052 Walker A motif; other site 452652019053 ATP binding site [chemical binding]; other site 452652019054 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 452652019055 potential frameshift: common BLAST hit: gi|239918312|ref|YP_002957870.1| integrase family protein 452652019056 Integrase core domain; Region: rve; pfam00665 452652019057 Integrase core domain; Region: rve_3; pfam13683 452652019058 Helix-turn-helix domain; Region: HTH_28; pfam13518 452652019059 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 452652019060 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 452652019061 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452652019062 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652019063 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 452652019064 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652019065 NAD(P) binding site [chemical binding]; other site 452652019066 active site 452652019067 DDE superfamily endonuclease; Region: DDE_5; cl17874 452652019068 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452652019069 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652019070 putative substrate translocation pore; other site 452652019071 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 452652019072 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 452652019073 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 452652019074 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 452652019075 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 452652019076 active site 452652019077 Substrate binding site; other site 452652019078 Mg++ binding site; other site 452652019079 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 452652019080 putative trimer interface [polypeptide binding]; other site 452652019081 putative CoA binding site [chemical binding]; other site 452652019082 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 452652019083 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 452652019084 active site 452652019085 substrate binding site [chemical binding]; other site 452652019086 metal binding site [ion binding]; metal-binding site 452652019087 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 452652019088 anti sigma factor interaction site; other site 452652019089 regulatory phosphorylation site [posttranslational modification]; other site 452652019090 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme; Region: E_set_GDE_N; cd11234 452652019091 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 452652019092 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 452652019093 active site 452652019094 catalytic site [active] 452652019095 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 452652019096 dimerization interface [polypeptide binding]; other site 452652019097 putative active cleft [active] 452652019098 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 452652019099 intracellular protease, PfpI family; Region: PfpI; TIGR01382 452652019100 conserved cys residue [active] 452652019101 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 452652019102 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 452652019103 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 452652019104 PYR/PP interface [polypeptide binding]; other site 452652019105 dimer interface [polypeptide binding]; other site 452652019106 TPP binding site [chemical binding]; other site 452652019107 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 452652019108 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 452652019109 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 452652019110 TPP-binding site [chemical binding]; other site 452652019111 dimer interface [polypeptide binding]; other site 452652019112 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 452652019113 conserved cys residue [active] 452652019114 trehalose synthase; Region: treS_nterm; TIGR02456 452652019115 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 452652019116 active site 452652019117 catalytic site [active] 452652019118 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 452652019119 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 452652019120 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 452652019121 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 452652019122 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 452652019123 MarR family; Region: MarR_2; pfam12802 452652019124 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 452652019125 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 452652019126 active site 452652019127 tetramer interface; other site 452652019128 ParB-like nuclease domain; Region: ParB; smart00470 452652019129 Major Facilitator Superfamily; Region: MFS_1; pfam07690 452652019130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652019131 putative substrate translocation pore; other site 452652019132 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652019133 short chain dehydrogenase; Provisional; Region: PRK06523 452652019134 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452652019135 NAD(P) binding site [chemical binding]; other site 452652019136 active site 452652019137 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452652019138 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452652019139 DNA binding residues [nucleotide binding] 452652019140 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 452652019141 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652019142 putative substrate translocation pore; other site 452652019143 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 452652019144 FAD binding domain; Region: FAD_binding_4; pfam01565 452652019145 Berberine and berberine like; Region: BBE; pfam08031 452652019146 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 452652019147 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 452652019148 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 452652019149 active site 452652019150 substrate binding site [chemical binding]; other site 452652019151 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 452652019152 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 452652019153 active site 452652019154 homodimer interface [polypeptide binding]; other site 452652019155 Family description; Region: VCBS; pfam13517 452652019156 Family description; Region: VCBS; pfam13517 452652019157 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 452652019158 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 452652019159 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 452652019160 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 452652019161 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 452652019162 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 452652019163 Major Facilitator Superfamily; Region: MFS_1; pfam07690 452652019164 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652019165 putative substrate translocation pore; other site 452652019166 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452652019167 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452652019168 salt bridge; other site 452652019169 non-specific DNA binding site [nucleotide binding]; other site 452652019170 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 452652019171 sequence-specific DNA binding site [nucleotide binding]; other site 452652019172 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 452652019173 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 452652019174 active site 452652019175 GH3 auxin-responsive promoter; Region: GH3; pfam03321 452652019176 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 452652019177 Leucine carboxyl methyltransferase; Region: LCM; cl01306 452652019178 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 452652019179 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 452652019180 dimerization interface [polypeptide binding]; other site 452652019181 Transcriptional regulator [Transcription]; Region: LysR; COG0583 452652019182 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 452652019183 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 452652019184 TAP-like protein; Region: Abhydrolase_4; pfam08386 452652019185 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452652019186 S-adenosylmethionine binding site [chemical binding]; other site 452652019187 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 452652019188 Cytochrome P450; Region: p450; cl12078 452652019189 LytB protein; Region: LYTB; cl00507 452652019190 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 452652019191 legume lectins; Region: lectin_L-type; cl14058 452652019192 homotetramer interaction site [polypeptide binding]; other site 452652019193 carbohydrate binding site [chemical binding]; other site 452652019194 metal binding site [ion binding]; metal-binding site 452652019195 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 452652019196 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 452652019197 active site 452652019198 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 452652019199 roof hairpin; other site 452652019200 oligomerisation interface [polypeptide binding]; other site 452652019201 potential frameshift: common BLAST hit: gi|345011036|ref|YP_004813390.1| amino acid permease 452652019202 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 452652019203 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 452652019204 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 452652019205 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 452652019206 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 452652019207 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 452652019208 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 452652019209 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 452652019210 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 452652019211 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 452652019212 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 452652019213 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 452652019214 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 452652019215 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 452652019216 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 452652019217 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 452652019218 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 452652019219 substrate binding pocket [chemical binding]; other site 452652019220 substrate-Mg2+ binding site; other site 452652019221 aspartate-rich region 1; other site 452652019222 aspartate-rich region 2; other site 452652019223 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 452652019224 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 452652019225 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 452652019226 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 452652019227 ATP binding site [chemical binding]; other site 452652019228 putative Mg++ binding site [ion binding]; other site 452652019229 Archaeal ATPase; Region: Arch_ATPase; pfam01637 452652019230 Integrase core domain; Region: rve; pfam00665 452652019231 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 452652019232 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 452652019233 ATP binding site [chemical binding]; other site 452652019234 putative Mg++ binding site [ion binding]; other site 452652019235 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 452652019236 nucleotide binding region [chemical binding]; other site 452652019237 ATP-binding site [chemical binding]; other site 452652019238 Helicase associated domain; Region: HA; pfam03457 452652019239 Helicase associated domain; Region: HA; pfam03457 452652019240 Helicase associated domain; Region: HA; pfam03457 452652019241 Helicase associated domain; Region: HA; pfam03457 452652019242 Helicase associated domain; Region: HA; pfam03457 452652019243 Helicase associated domain; Region: HA; pfam03457 452652019244 Helicase associated domain; Region: HA; pfam03457 452652019245 Nucleotidyltransferase domain; Region: NTP_transf_2; pfam01909 452652019246 metal binding triad [ion binding]; metal-binding site 452652019247 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 452652019248 Family description; Region: UvrD_C_2; pfam13538 452652019249 AAA domain; Region: AAA_23; pfam13476 452652019250 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 452652019251 G1 box; other site 452652019252 GTP/Mg2+ binding site [chemical binding]; other site 452652019253 G2 box; other site 452652019254 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 452652019255 active site 452652019256 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 452652019257 ATP binding site [chemical binding]; other site 452652019258 putative Mg++ binding site [ion binding]; other site 452652019259 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 452652019260 Helicase associated domain; Region: HA; pfam03457 452652019261 Helicase associated domain; Region: HA; pfam03457 452652019262 Helicase associated domain; Region: HA; pfam03457