-- dump date 20140619_120817 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1191061000001 DNA polymerase I; Provisional; Region: PRK05755 1191061000002 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1191061000003 active site 1191061000004 putative 5' ssDNA interaction site; other site 1191061000005 metal binding site 3; metal-binding site 1191061000006 metal binding site 1 [ion binding]; metal-binding site 1191061000007 metal binding site 2 [ion binding]; metal-binding site 1191061000008 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1191061000009 putative DNA binding site [nucleotide binding]; other site 1191061000010 putative metal binding site [ion binding]; other site 1191061000011 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1191061000012 active site 1191061000013 catalytic site [active] 1191061000014 substrate binding site [chemical binding]; other site 1191061000015 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1191061000016 active site 1191061000017 DNA binding site [nucleotide binding] 1191061000018 catalytic site [active] 1191061000019 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1191061000020 G1 box; other site 1191061000021 GTP/Mg2+ binding site [chemical binding]; other site 1191061000022 Switch I region; other site 1191061000023 G2 box; other site 1191061000024 G3 box; other site 1191061000025 Switch II region; other site 1191061000026 G4 box; other site 1191061000027 G5 box; other site 1191061000028 Der GTPase activator; Provisional; Region: PRK05244 1191061000029 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1191061000030 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1191061000031 FeS/SAM binding site; other site 1191061000032 HemN C-terminal domain; Region: HemN_C; pfam06969 1191061000033 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 1191061000034 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191061000035 active site 1191061000036 phosphorylation site [posttranslational modification] 1191061000037 intermolecular recognition site; other site 1191061000038 dimerization interface [polypeptide binding]; other site 1191061000039 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191061000040 Walker A motif; other site 1191061000041 ATP binding site [chemical binding]; other site 1191061000042 Walker B motif; other site 1191061000043 arginine finger; other site 1191061000044 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1191061000045 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 1191061000046 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1191061000047 putative active site [active] 1191061000048 heme pocket [chemical binding]; other site 1191061000049 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191061000050 dimer interface [polypeptide binding]; other site 1191061000051 phosphorylation site [posttranslational modification] 1191061000052 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191061000053 ATP binding site [chemical binding]; other site 1191061000054 Mg2+ binding site [ion binding]; other site 1191061000055 G-X-G motif; other site 1191061000056 glutamine synthetase; Provisional; Region: glnA; PRK09469 1191061000057 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1191061000058 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1191061000059 GTP-binding protein; Provisional; Region: PRK10218 1191061000060 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1191061000061 G1 box; other site 1191061000062 putative GEF interaction site [polypeptide binding]; other site 1191061000063 GTP/Mg2+ binding site [chemical binding]; other site 1191061000064 Switch I region; other site 1191061000065 G2 box; other site 1191061000066 G3 box; other site 1191061000067 Switch II region; other site 1191061000068 G4 box; other site 1191061000069 G5 box; other site 1191061000070 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1191061000071 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1191061000072 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1191061000073 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1191061000074 motif II; other site 1191061000075 hypothetical protein; Reviewed; Region: PRK01637 1191061000076 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1191061000077 dimerization interface [polypeptide binding]; other site 1191061000078 putative tRNAtyr binding site [nucleotide binding]; other site 1191061000079 putative active site [active] 1191061000080 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1191061000081 Coenzyme A binding pocket [chemical binding]; other site 1191061000082 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 1191061000083 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1191061000084 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1191061000085 substrate binding pocket [chemical binding]; other site 1191061000086 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 1191061000087 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 1191061000088 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 1191061000089 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1191061000090 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1191061000091 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1191061000092 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 1191061000093 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1191061000094 [4Fe-4S] binding site [ion binding]; other site 1191061000095 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1191061000096 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1191061000097 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1191061000098 molybdopterin cofactor binding site; other site 1191061000099 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1191061000100 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 1191061000101 active site 1191061000102 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 1191061000103 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 1191061000104 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 1191061000105 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 1191061000106 active site 1191061000107 phosphorylation site [posttranslational modification] 1191061000108 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1191061000109 metal binding site [ion binding]; metal-binding site 1191061000110 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 1191061000111 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1191061000112 active pocket/dimerization site; other site 1191061000113 active site 1191061000114 phosphorylation site [posttranslational modification] 1191061000115 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1191061000116 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191061000117 Walker A motif; other site 1191061000118 ATP binding site [chemical binding]; other site 1191061000119 Walker B motif; other site 1191061000120 arginine finger; other site 1191061000121 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1191061000122 active pocket/dimerization site; other site 1191061000123 active site 1191061000124 phosphorylation site [posttranslational modification] 1191061000125 PRD domain; Region: PRD; pfam00874 1191061000126 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 1191061000127 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1191061000128 active site 1191061000129 ADP/pyrophosphate binding site [chemical binding]; other site 1191061000130 dimerization interface [polypeptide binding]; other site 1191061000131 allosteric effector site; other site 1191061000132 fructose-1,6-bisphosphate binding site; other site 1191061000133 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1191061000134 active site 1191061000135 P-loop; other site 1191061000136 phosphorylation site [posttranslational modification] 1191061000137 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 1191061000138 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1191061000139 intersubunit interface [polypeptide binding]; other site 1191061000140 active site 1191061000141 zinc binding site [ion binding]; other site 1191061000142 Na+ binding site [ion binding]; other site 1191061000143 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1191061000144 active site 1191061000145 phosphorylation site [posttranslational modification] 1191061000146 AAA domain; Region: AAA_33; pfam13671 1191061000147 AAA domain; Region: AAA_17; pfam13207 1191061000148 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1191061000149 AzlC protein; Region: AzlC; cl00570 1191061000150 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1191061000151 non-specific DNA binding site [nucleotide binding]; other site 1191061000152 salt bridge; other site 1191061000153 sequence-specific DNA binding site [nucleotide binding]; other site 1191061000154 Cupin domain; Region: Cupin_2; cl17218 1191061000155 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1191061000156 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1191061000157 Coenzyme A binding pocket [chemical binding]; other site 1191061000158 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1191061000159 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1191061000160 CoA binding site [chemical binding]; other site 1191061000161 Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893 1191061000162 Acyl-CoA reductase LuxC; Region: ALDH_Acyl-CoA-Red_LuxC; cd07080 1191061000163 putative catalytic cysteine [active] 1191061000164 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1191061000165 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1191061000166 active site 1191061000167 AMP binding site [chemical binding]; other site 1191061000168 acyl-activating enzyme (AAE) consensus motif; other site 1191061000169 CoA binding site [chemical binding]; other site 1191061000170 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 1191061000171 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061000172 putative substrate translocation pore; other site 1191061000173 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1191061000174 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1191061000175 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1191061000176 DNA binding site [nucleotide binding] 1191061000177 domain linker motif; other site 1191061000178 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 1191061000179 ligand binding site [chemical binding]; other site 1191061000180 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 1191061000181 Melibiase; Region: Melibiase; pfam02065 1191061000182 galactoside permease; Reviewed; Region: lacY; PRK09528 1191061000183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061000184 putative substrate translocation pore; other site 1191061000185 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 1191061000186 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1191061000187 active site 1191061000188 substrate binding site [chemical binding]; other site 1191061000189 trimer interface [polypeptide binding]; other site 1191061000190 CoA binding site [chemical binding]; other site 1191061000191 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 1191061000192 Fimbrial protein; Region: Fimbrial; cl01416 1191061000193 Fimbrial protein; Region: Fimbrial; cl01416 1191061000194 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1191061000195 fimbrial assembly chaperone SthB; Provisional; Region: PRK15295 1191061000196 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1191061000197 outer membrane usher protein; Provisional; Region: PRK15193 1191061000198 PapC N-terminal domain; Region: PapC_N; pfam13954 1191061000199 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1191061000200 PapC C-terminal domain; Region: PapC_C; pfam13953 1191061000201 Fimbrial protein; Region: Fimbrial; cl01416 1191061000202 Fimbrial protein; Region: Fimbrial; cl01416 1191061000203 Fimbrial protein; Region: Fimbrial; cl01416 1191061000204 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1191061000205 O-Antigen ligase; Region: Wzy_C; pfam04932 1191061000206 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1191061000207 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 1191061000208 Conserved TM helix; Region: TM_helix; pfam05552 1191061000209 mechanosensitive channel MscS; Provisional; Region: PRK10334 1191061000210 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1191061000211 Protein of unknown function (DUF1375); Region: DUF1375; cl11456 1191061000212 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1191061000213 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1191061000214 DNA binding residues [nucleotide binding] 1191061000215 dimerization interface [polypeptide binding]; other site 1191061000216 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1191061000217 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1191061000218 domain linker motif; other site 1191061000219 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1191061000220 dimerization interface [polypeptide binding]; other site 1191061000221 ligand binding site [chemical binding]; other site 1191061000222 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1191061000223 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1191061000224 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1191061000225 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1191061000226 substrate binding [chemical binding]; other site 1191061000227 active site 1191061000228 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 1191061000229 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 1191061000230 lactaldehyde reductase; Region: lactal_redase; TIGR02638 1191061000231 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1191061000232 dimer interface [polypeptide binding]; other site 1191061000233 active site 1191061000234 metal binding site [ion binding]; metal-binding site 1191061000235 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1191061000236 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1191061000237 TM-ABC transporter signature motif; other site 1191061000238 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1191061000239 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1191061000240 TM-ABC transporter signature motif; other site 1191061000241 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1191061000242 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1191061000243 Walker A/P-loop; other site 1191061000244 ATP binding site [chemical binding]; other site 1191061000245 Q-loop/lid; other site 1191061000246 ABC transporter signature motif; other site 1191061000247 Walker B; other site 1191061000248 D-loop; other site 1191061000249 H-loop/switch region; other site 1191061000250 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1191061000251 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 1191061000252 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 1191061000253 ligand binding site [chemical binding]; other site 1191061000254 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1191061000255 intersubunit interface [polypeptide binding]; other site 1191061000256 active site 1191061000257 Zn2+ binding site [ion binding]; other site 1191061000258 L-rhamnose isomerase; Provisional; Region: PRK01076 1191061000259 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 1191061000260 N- and C-terminal domain interface [polypeptide binding]; other site 1191061000261 active site 1191061000262 putative catalytic site [active] 1191061000263 metal binding site [ion binding]; metal-binding site 1191061000264 ATP binding site [chemical binding]; other site 1191061000265 rhamnulokinase; Provisional; Region: rhaB; PRK10640 1191061000266 carbohydrate binding site [chemical binding]; other site 1191061000267 transcriptional activator RhaS; Provisional; Region: PRK13503 1191061000268 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1191061000269 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061000270 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061000271 transcriptional activator RhaR; Provisional; Region: PRK13502 1191061000272 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1191061000273 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061000274 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 1191061000275 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 1191061000276 superoxide dismutase; Provisional; Region: PRK10925 1191061000277 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1191061000278 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1191061000279 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 1191061000280 MOSC domain; Region: MOSC; pfam03473 1191061000281 3-alpha domain; Region: 3-alpha; pfam03475 1191061000282 two-component sensor protein; Provisional; Region: cpxA; PRK09470 1191061000283 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1191061000284 dimerization interface [polypeptide binding]; other site 1191061000285 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191061000286 dimer interface [polypeptide binding]; other site 1191061000287 phosphorylation site [posttranslational modification] 1191061000288 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191061000289 ATP binding site [chemical binding]; other site 1191061000290 Mg2+ binding site [ion binding]; other site 1191061000291 G-X-G motif; other site 1191061000292 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 1191061000293 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191061000294 active site 1191061000295 intermolecular recognition site; other site 1191061000296 dimerization interface [polypeptide binding]; other site 1191061000297 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1191061000298 DNA binding site [nucleotide binding] 1191061000299 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1191061000300 dimer interface [polypeptide binding]; other site 1191061000301 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 1191061000302 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1191061000303 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1191061000304 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1191061000305 active site 1191061000306 ADP/pyrophosphate binding site [chemical binding]; other site 1191061000307 dimerization interface [polypeptide binding]; other site 1191061000308 allosteric effector site; other site 1191061000309 fructose-1,6-bisphosphate binding site; other site 1191061000310 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1191061000311 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 1191061000312 UbiA prenyltransferase family; Region: UbiA; pfam01040 1191061000313 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1191061000314 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191061000315 Walker A motif; other site 1191061000316 ATP binding site [chemical binding]; other site 1191061000317 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1191061000318 Walker B motif; other site 1191061000319 arginine finger; other site 1191061000320 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1191061000321 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1191061000322 active site 1191061000323 HslU subunit interaction site [polypeptide binding]; other site 1191061000324 essential cell division protein FtsN; Provisional; Region: PRK10927 1191061000325 cell division protein FtsN; Provisional; Region: PRK12757 1191061000326 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1191061000327 DNA binding site [nucleotide binding] 1191061000328 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 1191061000329 domain linker motif; other site 1191061000330 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 1191061000331 dimerization interface [polypeptide binding]; other site 1191061000332 ligand binding site [chemical binding]; other site 1191061000333 primosome assembly protein PriA; Validated; Region: PRK05580 1191061000334 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1191061000335 ATP binding site [chemical binding]; other site 1191061000336 putative Mg++ binding site [ion binding]; other site 1191061000337 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1191061000338 ATP-binding site [chemical binding]; other site 1191061000339 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1191061000340 transcriptional repressor protein MetJ; Provisional; Region: PRK05264 1191061000341 corepressor binding sites; other site 1191061000342 cystathionine gamma-synthase; Provisional; Region: PRK08045 1191061000343 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1191061000344 homodimer interface [polypeptide binding]; other site 1191061000345 substrate-cofactor binding pocket; other site 1191061000346 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061000347 catalytic residue [active] 1191061000348 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 1191061000349 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 1191061000350 putative catalytic residues [active] 1191061000351 putative nucleotide binding site [chemical binding]; other site 1191061000352 putative aspartate binding site [chemical binding]; other site 1191061000353 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 1191061000354 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1191061000355 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1191061000356 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1191061000357 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1191061000358 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061000359 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1191061000360 dimerization interface [polypeptide binding]; other site 1191061000361 substrate binding pocket [chemical binding]; other site 1191061000362 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1191061000363 FAD binding site [chemical binding]; other site 1191061000364 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1191061000365 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1191061000366 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1191061000367 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1191061000368 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1191061000369 dimer interface [polypeptide binding]; other site 1191061000370 active site 1191061000371 metal binding site [ion binding]; metal-binding site 1191061000372 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1191061000373 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061000374 zinc/cadmium-binding protein; Provisional; Region: PRK10306 1191061000375 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1191061000376 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1191061000377 acetylornithine deacetylase; Provisional; Region: PRK05111 1191061000378 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1191061000379 metal binding site [ion binding]; metal-binding site 1191061000380 putative dimer interface [polypeptide binding]; other site 1191061000381 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1191061000382 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1191061000383 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 1191061000384 nucleotide binding site [chemical binding]; other site 1191061000385 N-acetyl-L-glutamate binding site [chemical binding]; other site 1191061000386 argininosuccinate lyase; Provisional; Region: PRK04833 1191061000387 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1191061000388 active sites [active] 1191061000389 tetramer interface [polypeptide binding]; other site 1191061000390 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1191061000391 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061000392 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1191061000393 dimerization interface [polypeptide binding]; other site 1191061000394 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1191061000395 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1191061000396 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1191061000397 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1191061000398 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1191061000399 hypothetical protein; Provisional; Region: PRK11056 1191061000400 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 1191061000401 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191061000402 S-adenosylmethionine binding site [chemical binding]; other site 1191061000403 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 1191061000404 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1191061000405 N-terminal plug; other site 1191061000406 ligand-binding site [chemical binding]; other site 1191061000407 glutamate racemase; Provisional; Region: PRK00865 1191061000408 transcriptional regulator HdfR; Provisional; Region: PRK03601 1191061000409 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061000410 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1191061000411 hypothetical protein; Provisional; Region: PRK11027 1191061000412 putative ATP-dependent protease; Provisional; Region: PRK09862 1191061000413 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1191061000414 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191061000415 Walker A motif; other site 1191061000416 ATP binding site [chemical binding]; other site 1191061000417 Walker B motif; other site 1191061000418 arginine finger; other site 1191061000419 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1191061000420 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 1191061000421 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1191061000422 dimer interface [polypeptide binding]; other site 1191061000423 PYR/PP interface [polypeptide binding]; other site 1191061000424 TPP binding site [chemical binding]; other site 1191061000425 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1191061000426 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1191061000427 TPP-binding site [chemical binding]; other site 1191061000428 dimer interface [polypeptide binding]; other site 1191061000429 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 1191061000430 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1191061000431 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1191061000432 homodimer interface [polypeptide binding]; other site 1191061000433 substrate-cofactor binding pocket; other site 1191061000434 catalytic residue [active] 1191061000435 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1191061000436 threonine dehydratase; Reviewed; Region: PRK09224 1191061000437 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1191061000438 tetramer interface [polypeptide binding]; other site 1191061000439 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061000440 catalytic residue [active] 1191061000441 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1191061000442 putative Ile/Val binding site [chemical binding]; other site 1191061000443 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1191061000444 putative Ile/Val binding site [chemical binding]; other site 1191061000445 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061000446 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 1191061000447 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 1191061000448 putative dimerization interface [polypeptide binding]; other site 1191061000449 ketol-acid reductoisomerase; Validated; Region: PRK05225 1191061000450 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1191061000451 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1191061000452 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1191061000453 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 1191061000454 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1191061000455 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1191061000456 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1191061000457 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1191061000458 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1191061000459 ligand binding site [chemical binding]; other site 1191061000460 flexible hinge region; other site 1191061000461 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1191061000462 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1191061000463 uridine phosphorylase; Provisional; Region: PRK11178 1191061000464 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 1191061000465 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 1191061000466 Part of AAA domain; Region: AAA_19; pfam13245 1191061000467 Family description; Region: UvrD_C_2; pfam13538 1191061000468 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1191061000469 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1191061000470 substrate binding site [chemical binding]; other site 1191061000471 ATP binding site [chemical binding]; other site 1191061000472 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1191061000473 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 1191061000474 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1191061000475 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1191061000476 DNA-binding site [nucleotide binding]; DNA binding site 1191061000477 UTRA domain; Region: UTRA; pfam07702 1191061000478 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 1191061000479 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1191061000480 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 1191061000481 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1191061000482 ATP binding site [chemical binding]; other site 1191061000483 Mg++ binding site [ion binding]; other site 1191061000484 motif III; other site 1191061000485 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1191061000486 nucleotide binding region [chemical binding]; other site 1191061000487 ATP-binding site [chemical binding]; other site 1191061000488 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1191061000489 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1191061000490 catalytic residues [active] 1191061000491 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1191061000492 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1191061000493 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1191061000494 RNA binding site [nucleotide binding]; other site 1191061000495 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1191061000496 multimer interface [polypeptide binding]; other site 1191061000497 Walker A motif; other site 1191061000498 ATP binding site [chemical binding]; other site 1191061000499 Walker B motif; other site 1191061000500 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 1191061000501 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1191061000502 Mg++ binding site [ion binding]; other site 1191061000503 putative catalytic motif [active] 1191061000504 substrate binding site [chemical binding]; other site 1191061000505 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 1191061000506 Chain length determinant protein; Region: Wzz; pfam02706 1191061000507 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 1191061000508 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1191061000509 homodimer interface [polypeptide binding]; other site 1191061000510 active site 1191061000511 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 1191061000512 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1191061000513 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1191061000514 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1191061000515 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 1191061000516 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1191061000517 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1191061000518 inhibitor-cofactor binding pocket; inhibition site 1191061000519 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061000520 catalytic residue [active] 1191061000521 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1191061000522 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 1191061000523 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 1191061000524 putative common antigen polymerase; Provisional; Region: PRK02975 1191061000525 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1191061000526 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1191061000527 putative transport protein YifK; Provisional; Region: PRK10746 1191061000528 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 1191061000529 HemY protein N-terminus; Region: HemY_N; pfam07219 1191061000530 Tetratricopeptide repeat; Region: TPR_2; pfam07719 1191061000531 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1191061000532 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 1191061000533 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1191061000534 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1191061000535 active site 1191061000536 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1191061000537 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1191061000538 active site 1191061000539 domain interfaces; other site 1191061000540 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 1191061000541 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 1191061000542 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 1191061000543 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 1191061000544 putative iron binding site [ion binding]; other site 1191061000545 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1191061000546 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061000547 putative substrate translocation pore; other site 1191061000548 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061000549 putative substrate translocation pore; other site 1191061000550 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1191061000551 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1191061000552 active site 1191061000553 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1191061000554 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1191061000555 DNA-binding site [nucleotide binding]; DNA binding site 1191061000556 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1191061000557 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061000558 homodimer interface [polypeptide binding]; other site 1191061000559 catalytic residue [active] 1191061000560 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 1191061000561 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1191061000562 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1191061000563 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1191061000564 hypothetical protein; Provisional; Region: PRK10963 1191061000565 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 1191061000566 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1191061000567 active site 1191061000568 Int/Topo IB signature motif; other site 1191061000569 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 1191061000570 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1191061000571 motif II; other site 1191061000572 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 1191061000573 Part of AAA domain; Region: AAA_19; pfam13245 1191061000574 Family description; Region: UvrD_C_2; pfam13538 1191061000575 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1191061000576 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 1191061000577 Cl binding site [ion binding]; other site 1191061000578 oligomer interface [polypeptide binding]; other site 1191061000579 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 1191061000580 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1191061000581 CoenzymeA binding site [chemical binding]; other site 1191061000582 subunit interaction site [polypeptide binding]; other site 1191061000583 PHB binding site; other site 1191061000584 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 1191061000585 dimerization interface [polypeptide binding]; other site 1191061000586 substrate binding site [chemical binding]; other site 1191061000587 active site 1191061000588 calcium binding site [ion binding]; other site 1191061000589 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 1191061000590 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1191061000591 ATP binding site [chemical binding]; other site 1191061000592 putative Mg++ binding site [ion binding]; other site 1191061000593 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1191061000594 nucleotide binding region [chemical binding]; other site 1191061000595 ATP-binding site [chemical binding]; other site 1191061000596 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1191061000597 Helicase and RNase D C-terminal; Region: HRDC; smart00341 1191061000598 threonine efflux system; Provisional; Region: PRK10229 1191061000599 putative transposase; Provisional; Region: PRK09857 1191061000600 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 1191061000601 lysophospholipase L2; Provisional; Region: PRK10749 1191061000602 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1191061000603 putative hydrolase; Provisional; Region: PRK10976 1191061000604 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1191061000605 active site 1191061000606 motif I; other site 1191061000607 motif II; other site 1191061000608 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1191061000609 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1191061000610 EamA-like transporter family; Region: EamA; pfam00892 1191061000611 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1191061000612 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1191061000613 THF binding site; other site 1191061000614 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1191061000615 substrate binding site [chemical binding]; other site 1191061000616 THF binding site; other site 1191061000617 zinc-binding site [ion binding]; other site 1191061000618 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1191061000619 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1191061000620 substrate binding pocket [chemical binding]; other site 1191061000621 membrane-bound complex binding site; other site 1191061000622 hinge residues; other site 1191061000623 Dienelactone hydrolase family; Region: DLH; pfam01738 1191061000624 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1191061000625 uridine phosphorylase; Provisional; Region: PRK11178 1191061000626 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 1191061000627 DNA recombination protein RmuC; Provisional; Region: PRK10361 1191061000628 RmuC family; Region: RmuC; pfam02646 1191061000629 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1191061000630 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191061000631 S-adenosylmethionine binding site [chemical binding]; other site 1191061000632 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 1191061000633 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 1191061000634 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1191061000635 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 1191061000636 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1191061000637 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 1191061000638 sec-independent translocase; Provisional; Region: PRK01770 1191061000639 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 1191061000640 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1191061000641 active site 1191061000642 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 1191061000643 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 1191061000644 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 1191061000645 FMN reductase; Validated; Region: fre; PRK08051 1191061000646 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 1191061000647 FAD binding pocket [chemical binding]; other site 1191061000648 FAD binding motif [chemical binding]; other site 1191061000649 phosphate binding motif [ion binding]; other site 1191061000650 beta-alpha-beta structure motif; other site 1191061000651 NAD binding pocket [chemical binding]; other site 1191061000652 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 1191061000653 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1191061000654 dimer interface [polypeptide binding]; other site 1191061000655 active site 1191061000656 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1191061000657 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1191061000658 substrate binding site [chemical binding]; other site 1191061000659 oxyanion hole (OAH) forming residues; other site 1191061000660 trimer interface [polypeptide binding]; other site 1191061000661 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1191061000662 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1191061000663 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1191061000664 proline dipeptidase; Provisional; Region: PRK13607 1191061000665 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1191061000666 active site 1191061000667 hypothetical protein; Provisional; Region: PRK11568 1191061000668 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1191061000669 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1191061000670 potassium transporter; Provisional; Region: PRK10750 1191061000671 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1191061000672 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 1191061000673 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 1191061000674 FAD binding domain; Region: FAD_binding_4; pfam01565 1191061000675 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1191061000676 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1191061000677 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1191061000678 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1191061000679 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1191061000680 pantothenate kinase; Provisional; Region: PRK05439 1191061000681 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1191061000682 ATP-binding site [chemical binding]; other site 1191061000683 CoA-binding site [chemical binding]; other site 1191061000684 Mg2+-binding site [ion binding]; other site 1191061000685 elongation factor Tu; Reviewed; Region: PRK00049 1191061000686 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1191061000687 G1 box; other site 1191061000688 GEF interaction site [polypeptide binding]; other site 1191061000689 GTP/Mg2+ binding site [chemical binding]; other site 1191061000690 Switch I region; other site 1191061000691 G2 box; other site 1191061000692 G3 box; other site 1191061000693 Switch II region; other site 1191061000694 G4 box; other site 1191061000695 G5 box; other site 1191061000696 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1191061000697 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1191061000698 Antibiotic Binding Site [chemical binding]; other site 1191061000699 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 1191061000700 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1191061000701 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1191061000702 putative homodimer interface [polypeptide binding]; other site 1191061000703 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1191061000704 heterodimer interface [polypeptide binding]; other site 1191061000705 homodimer interface [polypeptide binding]; other site 1191061000706 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1191061000707 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1191061000708 L7/L12 interface [polypeptide binding]; other site 1191061000709 23S rRNA interface [nucleotide binding]; other site 1191061000710 L25 interface [polypeptide binding]; other site 1191061000711 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1191061000712 mRNA/rRNA interface [nucleotide binding]; other site 1191061000713 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1191061000714 23S rRNA interface [nucleotide binding]; other site 1191061000715 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1191061000716 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1191061000717 core dimer interface [polypeptide binding]; other site 1191061000718 peripheral dimer interface [polypeptide binding]; other site 1191061000719 L10 interface [polypeptide binding]; other site 1191061000720 L11 interface [polypeptide binding]; other site 1191061000721 putative EF-Tu interaction site [polypeptide binding]; other site 1191061000722 putative EF-G interaction site [polypeptide binding]; other site 1191061000723 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1191061000724 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1191061000725 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1191061000726 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1191061000727 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1191061000728 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1191061000729 RPB3 interaction site [polypeptide binding]; other site 1191061000730 RPB1 interaction site [polypeptide binding]; other site 1191061000731 RPB11 interaction site [polypeptide binding]; other site 1191061000732 RPB10 interaction site [polypeptide binding]; other site 1191061000733 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1191061000734 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1191061000735 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1191061000736 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1191061000737 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1191061000738 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1191061000739 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1191061000740 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1191061000741 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1191061000742 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1191061000743 DNA binding site [nucleotide binding] 1191061000744 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1191061000745 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1191061000746 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 1191061000747 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1191061000748 methionine cluster; other site 1191061000749 active site 1191061000750 phosphorylation site [posttranslational modification] 1191061000751 metal binding site [ion binding]; metal-binding site 1191061000752 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1191061000753 Cache domain; Region: Cache_1; pfam02743 1191061000754 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1191061000755 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1191061000756 metal binding site [ion binding]; metal-binding site 1191061000757 active site 1191061000758 I-site; other site 1191061000759 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 1191061000760 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1191061000761 FeS/SAM binding site; other site 1191061000762 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1191061000763 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1191061000764 ThiS interaction site; other site 1191061000765 putative active site [active] 1191061000766 tetramer interface [polypeptide binding]; other site 1191061000767 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1191061000768 thiS-thiF/thiG interaction site; other site 1191061000769 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1191061000770 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 1191061000771 ATP binding site [chemical binding]; other site 1191061000772 substrate interface [chemical binding]; other site 1191061000773 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1191061000774 thiamine phosphate binding site [chemical binding]; other site 1191061000775 active site 1191061000776 pyrophosphate binding site [ion binding]; other site 1191061000777 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1191061000778 ThiC-associated domain; Region: ThiC-associated; pfam13667 1191061000779 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1191061000780 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 1191061000781 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1191061000782 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1191061000783 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1191061000784 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1191061000785 putative NADH binding site [chemical binding]; other site 1191061000786 putative active site [active] 1191061000787 nudix motif; other site 1191061000788 putative metal binding site [ion binding]; other site 1191061000789 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1191061000790 substrate binding site [chemical binding]; other site 1191061000791 active site 1191061000792 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1191061000793 Active_site [active] 1191061000794 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 1191061000795 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1191061000796 IHF dimer interface [polypeptide binding]; other site 1191061000797 IHF - DNA interface [nucleotide binding]; other site 1191061000798 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 1191061000799 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1191061000800 dimer interface [polypeptide binding]; other site 1191061000801 sensor protein ZraS; Provisional; Region: PRK10364 1191061000802 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191061000803 dimer interface [polypeptide binding]; other site 1191061000804 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191061000805 ATP binding site [chemical binding]; other site 1191061000806 Mg2+ binding site [ion binding]; other site 1191061000807 G-X-G motif; other site 1191061000808 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 1191061000809 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191061000810 active site 1191061000811 phosphorylation site [posttranslational modification] 1191061000812 intermolecular recognition site; other site 1191061000813 dimerization interface [polypeptide binding]; other site 1191061000814 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191061000815 Walker A motif; other site 1191061000816 ATP binding site [chemical binding]; other site 1191061000817 Walker B motif; other site 1191061000818 arginine finger; other site 1191061000819 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1191061000820 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1191061000821 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1191061000822 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1191061000823 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1191061000824 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1191061000825 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1191061000826 purine monophosphate binding site [chemical binding]; other site 1191061000827 dimer interface [polypeptide binding]; other site 1191061000828 putative catalytic residues [active] 1191061000829 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1191061000830 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1191061000831 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1191061000832 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1191061000833 Coenzyme A binding pocket [chemical binding]; other site 1191061000834 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1191061000835 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1191061000836 proposed active site lysine [active] 1191061000837 conserved cys residue [active] 1191061000838 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 1191061000839 malate synthase A; Region: malate_syn_A; TIGR01344 1191061000840 active site 1191061000841 isocitrate lyase; Provisional; Region: PRK15063 1191061000842 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1191061000843 tetramer interface [polypeptide binding]; other site 1191061000844 active site 1191061000845 Mg2+/Mn2+ binding site [ion binding]; other site 1191061000846 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 1191061000847 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 1191061000848 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 1191061000849 transcriptional repressor IclR; Provisional; Region: PRK11569 1191061000850 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1191061000851 Bacterial transcriptional regulator; Region: IclR; pfam01614 1191061000852 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1191061000853 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1191061000854 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1191061000855 substrate binding pocket [chemical binding]; other site 1191061000856 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1191061000857 B12 binding site [chemical binding]; other site 1191061000858 cobalt ligand [ion binding]; other site 1191061000859 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1191061000860 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1191061000861 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1191061000862 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1191061000863 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1191061000864 active site pocket [active] 1191061000865 oxyanion hole [active] 1191061000866 catalytic triad [active] 1191061000867 active site nucleophile [active] 1191061000868 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 1191061000869 CcdB protein; Region: CcdB; cl03380 1191061000870 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 1191061000871 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1191061000872 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1191061000873 shikimate binding site; other site 1191061000874 NAD(P) binding site [chemical binding]; other site 1191061000875 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 1191061000876 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1191061000877 putative NAD(P) binding site [chemical binding]; other site 1191061000878 catalytic Zn binding site [ion binding]; other site 1191061000879 PTS system, mannose/fructose/sorbose family, IID component; Region: EIID-AGA; TIGR00828 1191061000880 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1191061000881 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1191061000882 active site 1191061000883 phosphorylation site [posttranslational modification] 1191061000884 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1191061000885 active pocket/dimerization site; other site 1191061000886 active site 1191061000887 phosphorylation site [posttranslational modification] 1191061000888 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 1191061000889 classical (c) SDRs; Region: SDR_c; cd05233 1191061000890 NAD(P) binding site [chemical binding]; other site 1191061000891 active site 1191061000892 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1191061000893 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1191061000894 putative DNA binding site [nucleotide binding]; other site 1191061000895 putative Zn2+ binding site [ion binding]; other site 1191061000896 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1191061000897 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 1191061000898 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1191061000899 RNA binding surface [nucleotide binding]; other site 1191061000900 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 1191061000901 probable active site [active] 1191061000902 hypothetical protein; Provisional; Region: PRK10515 1191061000903 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1191061000904 Sodium Bile acid symporter family; Region: SBF; cl17470 1191061000905 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 1191061000906 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 1191061000907 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191061000908 Walker A motif; other site 1191061000909 ATP binding site [chemical binding]; other site 1191061000910 Walker B motif; other site 1191061000911 arginine finger; other site 1191061000912 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1191061000913 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1191061000914 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 1191061000915 aspartate kinase III; Validated; Region: PRK09084 1191061000916 AAK_AKiii-LysC-EC: Amino Acid Kinase Superfamily (AAK), AKiii-LysC-EC: this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKIII. AKIII is a monofunctional class enzyme (LysC) found in some...; Region: AAK_AKiii-LysC-EC; cd04258 1191061000917 nucleotide binding site [chemical binding]; other site 1191061000918 putative catalytic residues [active] 1191061000919 aspartate binding site [chemical binding]; other site 1191061000920 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 1191061000921 lysine allosteric regulatory site; other site 1191061000922 dimer interface [polypeptide binding]; other site 1191061000923 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 1191061000924 dimer interface [polypeptide binding]; other site 1191061000925 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1191061000926 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1191061000927 active site 1191061000928 dimer interface [polypeptide binding]; other site 1191061000929 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1191061000930 dimer interface [polypeptide binding]; other site 1191061000931 active site 1191061000932 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 1191061000933 putative trimer interface [polypeptide binding]; other site 1191061000934 putative active site [active] 1191061000935 putative substrate binding site [chemical binding]; other site 1191061000936 putative CoA binding site [chemical binding]; other site 1191061000937 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1191061000938 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1191061000939 Coenzyme A binding pocket [chemical binding]; other site 1191061000940 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1191061000941 homotrimer interaction site [polypeptide binding]; other site 1191061000942 putative active site [active] 1191061000943 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1191061000944 AzlC protein; Region: AzlC; pfam03591 1191061000945 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 1191061000946 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 1191061000947 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1191061000948 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061000949 dimer interface [polypeptide binding]; other site 1191061000950 conserved gate region; other site 1191061000951 putative PBP binding loops; other site 1191061000952 ABC-ATPase subunit interface; other site 1191061000953 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061000954 dimer interface [polypeptide binding]; other site 1191061000955 conserved gate region; other site 1191061000956 putative PBP binding loops; other site 1191061000957 ABC-ATPase subunit interface; other site 1191061000958 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 1191061000959 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1191061000960 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 1191061000961 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1191061000962 Walker A/P-loop; other site 1191061000963 ATP binding site [chemical binding]; other site 1191061000964 Q-loop/lid; other site 1191061000965 ABC transporter signature motif; other site 1191061000966 Walker B; other site 1191061000967 D-loop; other site 1191061000968 H-loop/switch region; other site 1191061000969 TOBE domain; Region: TOBE_2; pfam08402 1191061000970 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1191061000971 trimer interface; other site 1191061000972 sugar binding site [chemical binding]; other site 1191061000973 maltose regulon periplasmic protein; Provisional; Region: PRK10564 1191061000974 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 1191061000975 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 1191061000976 UbiA prenyltransferase family; Region: UbiA; pfam01040 1191061000977 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 1191061000978 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1191061000979 putative acyl-acceptor binding pocket; other site 1191061000980 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1191061000981 LexA repressor; Validated; Region: PRK00215 1191061000982 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1191061000983 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1191061000984 Catalytic site [active] 1191061000985 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 1191061000986 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1191061000987 hypothetical protein; Provisional; Region: PRK10428 1191061000988 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1191061000989 metal binding site 2 [ion binding]; metal-binding site 1191061000990 putative DNA binding helix; other site 1191061000991 metal binding site 1 [ion binding]; metal-binding site 1191061000992 dimer interface [polypeptide binding]; other site 1191061000993 structural Zn2+ binding site [ion binding]; other site 1191061000994 Cupin domain; Region: Cupin_2; cl17218 1191061000995 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1191061000996 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1191061000997 FMN binding site [chemical binding]; other site 1191061000998 active site 1191061000999 catalytic residues [active] 1191061001000 substrate binding site [chemical binding]; other site 1191061001001 phage shock protein G; Reviewed; Region: pspG; PRK09459 1191061001002 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1191061001003 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1191061001004 NADP binding site [chemical binding]; other site 1191061001005 dimer interface [polypeptide binding]; other site 1191061001006 replicative DNA helicase; Provisional; Region: PRK08006 1191061001007 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1191061001008 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1191061001009 Walker A motif; other site 1191061001010 ATP binding site [chemical binding]; other site 1191061001011 Walker B motif; other site 1191061001012 DNA binding loops [nucleotide binding] 1191061001013 alanine racemase; Reviewed; Region: alr; PRK00053 1191061001014 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1191061001015 active site 1191061001016 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1191061001017 substrate binding site [chemical binding]; other site 1191061001018 catalytic residues [active] 1191061001019 dimer interface [polypeptide binding]; other site 1191061001020 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1191061001021 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1191061001022 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061001023 homodimer interface [polypeptide binding]; other site 1191061001024 catalytic residue [active] 1191061001025 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1191061001026 active site 1191061001027 motif I; other site 1191061001028 motif II; other site 1191061001029 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1191061001030 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 1191061001031 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1191061001032 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1191061001033 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1191061001034 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1191061001035 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1191061001036 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1191061001037 dimer interface [polypeptide binding]; other site 1191061001038 ssDNA binding site [nucleotide binding]; other site 1191061001039 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1191061001040 putative single-stranded DNA-binding protein; Region: PHA01740 1191061001041 Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein [Cell envelope biogenesis, outer membrane]; Region: COG4623 1191061001042 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1191061001043 substrate binding pocket [chemical binding]; other site 1191061001044 membrane-bound complex binding site; other site 1191061001045 hinge residues; other site 1191061001046 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1191061001047 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1191061001048 catalytic residue [active] 1191061001049 outer membrane receptor FepA; Provisional; Region: PRK13524 1191061001050 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1191061001051 N-terminal plug; other site 1191061001052 ligand-binding site [chemical binding]; other site 1191061001053 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061001054 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1191061001055 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061001056 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 1191061001057 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1191061001058 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1191061001059 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1191061001060 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1191061001061 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1191061001062 Surface antigen; Region: Bac_surface_Ag; pfam01103 1191061001063 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1191061001064 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1191061001065 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1191061001066 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1191061001067 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061001068 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 1191061001069 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 1191061001070 DNA binding residues [nucleotide binding] 1191061001071 dimer interface [polypeptide binding]; other site 1191061001072 [2Fe-2S] cluster binding site [ion binding]; other site 1191061001073 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1191061001074 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1191061001075 putative C-terminal domain interface [polypeptide binding]; other site 1191061001076 putative GSH binding site (G-site) [chemical binding]; other site 1191061001077 putative dimer interface [polypeptide binding]; other site 1191061001078 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 1191061001079 putative N-terminal domain interface [polypeptide binding]; other site 1191061001080 putative dimer interface [polypeptide binding]; other site 1191061001081 putative substrate binding pocket (H-site) [chemical binding]; other site 1191061001082 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1191061001083 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1191061001084 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1191061001085 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061001086 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061001087 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1191061001088 putative dimerization interface [polypeptide binding]; other site 1191061001089 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 1191061001090 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1191061001091 Fimbrial protein; Region: Fimbrial; cl01416 1191061001092 fimbrial assembly chaperone SthB; Provisional; Region: PRK15295 1191061001093 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1191061001094 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1191061001095 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1191061001096 PapC N-terminal domain; Region: PapC_N; pfam13954 1191061001097 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1191061001098 PapC C-terminal domain; Region: PapC_C; pfam13953 1191061001099 putative major fimbrial protein SthE; Provisional; Region: PRK15292 1191061001100 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1191061001101 putative major fimbrial protein SthE; Provisional; Region: PRK15292 1191061001102 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1191061001103 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1191061001104 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1191061001105 Na binding site [ion binding]; other site 1191061001106 Predicted membrane protein [Function unknown]; Region: COG3162 1191061001107 acetyl-CoA synthetase; Provisional; Region: PRK00174 1191061001108 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1191061001109 active site 1191061001110 CoA binding site [chemical binding]; other site 1191061001111 acyl-activating enzyme (AAE) consensus motif; other site 1191061001112 AMP binding site [chemical binding]; other site 1191061001113 acetate binding site [chemical binding]; other site 1191061001114 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 1191061001115 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1191061001116 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1191061001117 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1191061001118 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1191061001119 [4Fe-4S] binding site [ion binding]; other site 1191061001120 molybdopterin cofactor binding site; other site 1191061001121 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 1191061001122 molybdopterin cofactor binding site; other site 1191061001123 D-allose kinase; Provisional; Region: PRK09698 1191061001124 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1191061001125 nucleotide binding site [chemical binding]; other site 1191061001126 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1191061001127 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1191061001128 substrate binding site [chemical binding]; other site 1191061001129 hexamer interface [polypeptide binding]; other site 1191061001130 metal binding site [ion binding]; metal-binding site 1191061001131 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1191061001132 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1191061001133 TM-ABC transporter signature motif; other site 1191061001134 D-allose transporter ATP-binding protein; Provisional; Region: PRK09700 1191061001135 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1191061001136 Walker A/P-loop; other site 1191061001137 ATP binding site [chemical binding]; other site 1191061001138 Q-loop/lid; other site 1191061001139 ABC transporter signature motif; other site 1191061001140 Walker B; other site 1191061001141 D-loop; other site 1191061001142 H-loop/switch region; other site 1191061001143 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1191061001144 D-allose transporter subunit; Provisional; Region: PRK09701 1191061001145 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1191061001146 DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337 1191061001147 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1191061001148 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1191061001149 putative active site [active] 1191061001150 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1191061001151 putative hydrolase; Provisional; Region: PRK02113 1191061001152 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 1191061001153 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 1191061001154 active site 1191061001155 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 1191061001156 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1191061001157 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 1191061001158 active site 1191061001159 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 1191061001160 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1191061001161 Walker A/P-loop; other site 1191061001162 ATP binding site [chemical binding]; other site 1191061001163 Q-loop/lid; other site 1191061001164 ABC transporter signature motif; other site 1191061001165 Walker B; other site 1191061001166 D-loop; other site 1191061001167 H-loop/switch region; other site 1191061001168 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 1191061001169 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1191061001170 Walker A/P-loop; other site 1191061001171 ATP binding site [chemical binding]; other site 1191061001172 Q-loop/lid; other site 1191061001173 ABC transporter signature motif; other site 1191061001174 Walker B; other site 1191061001175 D-loop; other site 1191061001176 H-loop/switch region; other site 1191061001177 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1191061001178 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 1191061001179 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 1191061001180 carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147 1191061001181 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 1191061001182 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 1191061001183 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1191061001184 DNA-binding site [nucleotide binding]; DNA binding site 1191061001185 UTRA domain; Region: UTRA; pfam07702 1191061001186 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1191061001187 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1191061001188 dimer interface [polypeptide binding]; other site 1191061001189 hypothetical protein; Provisional; Region: PRK10220 1191061001190 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1191061001191 PhnA protein; Region: PhnA; pfam03831 1191061001192 proline/glycine betaine transporter; Provisional; Region: PRK10642 1191061001193 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061001194 putative substrate translocation pore; other site 1191061001195 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 1191061001196 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 1191061001197 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 1191061001198 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 1191061001199 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1191061001200 HSP70 interaction site [polypeptide binding]; other site 1191061001201 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1191061001202 substrate binding site [polypeptide binding]; other site 1191061001203 dimer interface [polypeptide binding]; other site 1191061001204 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 1191061001205 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1191061001206 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 1191061001207 catalytic residues [active] 1191061001208 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1191061001209 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1191061001210 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1191061001211 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1191061001212 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 1191061001213 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 1191061001214 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1191061001215 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1191061001216 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1191061001217 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1191061001218 active site 1191061001219 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 1191061001220 putative transcriptional regulator; Provisional; Region: PRK11640 1191061001221 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 1191061001222 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 1191061001223 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1191061001224 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1191061001225 DsbD alpha interface [polypeptide binding]; other site 1191061001226 catalytic residues [active] 1191061001227 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 1191061001228 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1191061001229 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 1191061001230 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1191061001231 Aspartase; Region: Aspartase; cd01357 1191061001232 active sites [active] 1191061001233 tetramer interface [polypeptide binding]; other site 1191061001234 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 1191061001235 putative transporter; Provisional; Region: PRK11021 1191061001236 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1191061001237 oligomerisation interface [polypeptide binding]; other site 1191061001238 mobile loop; other site 1191061001239 roof hairpin; other site 1191061001240 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1191061001241 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1191061001242 ring oligomerisation interface [polypeptide binding]; other site 1191061001243 ATP/Mg binding site [chemical binding]; other site 1191061001244 stacking interactions; other site 1191061001245 hinge regions; other site 1191061001246 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 1191061001247 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 1191061001248 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 1191061001249 putative active site [active] 1191061001250 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1191061001251 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 1191061001252 Walker A/P-loop; other site 1191061001253 ATP binding site [chemical binding]; other site 1191061001254 Q-loop/lid; other site 1191061001255 ABC transporter signature motif; other site 1191061001256 Walker B; other site 1191061001257 D-loop; other site 1191061001258 H-loop/switch region; other site 1191061001259 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1191061001260 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1191061001261 HlyD family secretion protein; Region: HlyD_3; pfam13437 1191061001262 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1191061001263 PapC N-terminal domain; Region: PapC_N; pfam13954 1191061001264 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1191061001265 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1191061001266 PapC C-terminal domain; Region: PapC_C; pfam13953 1191061001267 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1191061001268 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1191061001269 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1191061001270 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 1191061001271 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1191061001272 DNA binding site [nucleotide binding] 1191061001273 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1191061001274 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1191061001275 FeS/SAM binding site; other site 1191061001276 elongation factor P; Validated; Region: PRK00529 1191061001277 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1191061001278 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1191061001279 RNA binding site [nucleotide binding]; other site 1191061001280 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1191061001281 RNA binding site [nucleotide binding]; other site 1191061001282 Entericidin EcnA/B family; Region: Entericidin; pfam08085 1191061001283 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 1191061001284 multidrug efflux system protein; Provisional; Region: PRK11431 1191061001285 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 1191061001286 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1191061001287 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 1191061001288 Iron-sulfur protein interface; other site 1191061001289 proximal quinone binding site [chemical binding]; other site 1191061001290 C-subunit interface; other site 1191061001291 distal quinone binding site; other site 1191061001292 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 1191061001293 D-subunit interface [polypeptide binding]; other site 1191061001294 Iron-sulfur protein interface; other site 1191061001295 proximal quinone binding site [chemical binding]; other site 1191061001296 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 1191061001297 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1191061001298 catalytic loop [active] 1191061001299 iron binding site [ion binding]; other site 1191061001300 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 1191061001301 L-aspartate oxidase; Provisional; Region: PRK06175 1191061001302 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1191061001303 poxB regulator PoxA; Provisional; Region: PRK09350 1191061001304 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1191061001305 motif 1; other site 1191061001306 dimer interface [polypeptide binding]; other site 1191061001307 active site 1191061001308 motif 2; other site 1191061001309 motif 3; other site 1191061001310 inner membrane transporter YjeM; Provisional; Region: PRK15238 1191061001311 putative mechanosensitive channel protein; Provisional; Region: PRK10929 1191061001312 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1191061001313 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1191061001314 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 1191061001315 GTPase RsgA; Reviewed; Region: PRK12288 1191061001316 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1191061001317 RNA binding site [nucleotide binding]; other site 1191061001318 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1191061001319 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1191061001320 GTP/Mg2+ binding site [chemical binding]; other site 1191061001321 G4 box; other site 1191061001322 G5 box; other site 1191061001323 G1 box; other site 1191061001324 Switch I region; other site 1191061001325 G2 box; other site 1191061001326 G3 box; other site 1191061001327 Switch II region; other site 1191061001328 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1191061001329 catalytic site [active] 1191061001330 putative active site [active] 1191061001331 putative substrate binding site [chemical binding]; other site 1191061001332 dimer interface [polypeptide binding]; other site 1191061001333 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1191061001334 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1191061001335 substrate binding pocket [chemical binding]; other site 1191061001336 membrane-bound complex binding site; other site 1191061001337 hinge residues; other site 1191061001338 epoxyqueuosine reductase; Region: TIGR00276 1191061001339 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1191061001340 putative carbohydrate kinase; Provisional; Region: PRK10565 1191061001341 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1191061001342 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1191061001343 putative substrate binding site [chemical binding]; other site 1191061001344 putative ATP binding site [chemical binding]; other site 1191061001345 ADP-binding protein; Provisional; Region: PRK10646 1191061001346 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 1191061001347 AMIN domain; Region: AMIN; pfam11741 1191061001348 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1191061001349 active site 1191061001350 metal binding site [ion binding]; metal-binding site 1191061001351 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191061001352 Mg2+ binding site [ion binding]; other site 1191061001353 G-X-G motif; other site 1191061001354 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1191061001355 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 1191061001356 ATP binding site [chemical binding]; other site 1191061001357 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1191061001358 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1191061001359 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1191061001360 bacterial Hfq-like; Region: Hfq; cd01716 1191061001361 hexamer interface [polypeptide binding]; other site 1191061001362 Sm1 motif; other site 1191061001363 RNA binding site [nucleotide binding]; other site 1191061001364 Sm2 motif; other site 1191061001365 GTPase HflX; Provisional; Region: PRK11058 1191061001366 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1191061001367 HflX GTPase family; Region: HflX; cd01878 1191061001368 G1 box; other site 1191061001369 GTP/Mg2+ binding site [chemical binding]; other site 1191061001370 Switch I region; other site 1191061001371 G2 box; other site 1191061001372 G3 box; other site 1191061001373 Switch II region; other site 1191061001374 G4 box; other site 1191061001375 G5 box; other site 1191061001376 FtsH protease regulator HflK; Provisional; Region: PRK10930 1191061001377 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 1191061001378 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1191061001379 FtsH protease regulator HflC; Provisional; Region: PRK11029 1191061001380 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1191061001381 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 1191061001382 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1191061001383 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1191061001384 IMP binding site; other site 1191061001385 Predicted transcriptional regulator [Transcription]; Region: COG1959 1191061001386 transcriptional repressor NsrR; Provisional; Region: PRK11014 1191061001387 exoribonuclease R; Provisional; Region: PRK11642 1191061001388 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1191061001389 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1191061001390 RNB domain; Region: RNB; pfam00773 1191061001391 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1191061001392 RNA binding site [nucleotide binding]; other site 1191061001393 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 1191061001394 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1191061001395 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1191061001396 Uncharacterized protein family (UPF0128); Region: UPF0128; cl00799 1191061001397 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1191061001398 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 1191061001399 FAD binding site [chemical binding]; other site 1191061001400 substrate binding site [chemical binding]; other site 1191061001401 catalytic residues [active] 1191061001402 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1191061001403 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 1191061001404 esterase; Provisional; Region: PRK10566 1191061001405 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1191061001406 transcriptional repressor UlaR; Provisional; Region: PRK13509 1191061001407 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1191061001408 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1191061001409 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 1191061001410 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1191061001411 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 1191061001412 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 1191061001413 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1191061001414 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1191061001415 active site 1191061001416 phosphorylation site [posttranslational modification] 1191061001417 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1191061001418 active site 1191061001419 dimer interface [polypeptide binding]; other site 1191061001420 magnesium binding site [ion binding]; other site 1191061001421 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 1191061001422 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1191061001423 AP (apurinic/apyrimidinic) site pocket; other site 1191061001424 DNA interaction; other site 1191061001425 Metal-binding active site; metal-binding site 1191061001426 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1191061001427 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1191061001428 intersubunit interface [polypeptide binding]; other site 1191061001429 active site 1191061001430 Zn2+ binding site [ion binding]; other site 1191061001431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061001432 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1191061001433 putative substrate translocation pore; other site 1191061001434 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1191061001435 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1191061001436 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1191061001437 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1191061001438 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1191061001439 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1191061001440 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1191061001441 EamA-like transporter family; Region: EamA; pfam00892 1191061001442 EamA-like transporter family; Region: EamA; pfam00892 1191061001443 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 1191061001444 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 1191061001445 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1191061001446 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1191061001447 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1191061001448 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 1191061001449 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 1191061001450 Hemerythrin-like domain; Region: Hr-like; cd12108 1191061001451 Fe binding site [ion binding]; other site 1191061001452 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1191061001453 EamA-like transporter family; Region: EamA; pfam00892 1191061001454 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1191061001455 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1191061001456 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061001457 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061001458 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1191061001459 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1191061001460 NADP binding site [chemical binding]; other site 1191061001461 Predicted transcriptional regulators [Transcription]; Region: COG1733 1191061001462 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1191061001463 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 1191061001464 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1191061001465 active site 1191061001466 metal binding site [ion binding]; metal-binding site 1191061001467 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1191061001468 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1191061001469 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1191061001470 active site 1191061001471 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 1191061001472 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 1191061001473 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 1191061001474 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1191061001475 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061001476 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061001477 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1191061001478 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1191061001479 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1191061001480 galactoside permease; Reviewed; Region: lacY; PRK09528 1191061001481 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1191061001482 Domain of unknown function DUF21; Region: DUF21; pfam01595 1191061001483 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1191061001484 Transporter associated domain; Region: CorC_HlyC; smart01091 1191061001485 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1191061001486 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 1191061001487 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1191061001488 Surface antigen; Region: Bac_surface_Ag; pfam01103 1191061001489 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1191061001490 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1191061001491 Family of unknown function (DUF490); Region: DUF490; pfam04357 1191061001492 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1191061001493 dimerization interface [polypeptide binding]; other site 1191061001494 putative active site pocket [active] 1191061001495 putative catalytic residue [active] 1191061001496 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1191061001497 dimer interface [polypeptide binding]; other site 1191061001498 substrate binding site [chemical binding]; other site 1191061001499 metal binding sites [ion binding]; metal-binding site 1191061001500 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 1191061001501 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1191061001502 putative ligand binding site [chemical binding]; other site 1191061001503 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1191061001504 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1191061001505 Walker A/P-loop; other site 1191061001506 ATP binding site [chemical binding]; other site 1191061001507 Q-loop/lid; other site 1191061001508 ABC transporter signature motif; other site 1191061001509 Walker B; other site 1191061001510 D-loop; other site 1191061001511 H-loop/switch region; other site 1191061001512 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1191061001513 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1191061001514 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1191061001515 TM-ABC transporter signature motif; other site 1191061001516 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1191061001517 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1191061001518 TM-ABC transporter signature motif; other site 1191061001519 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1191061001520 AMP binding site [chemical binding]; other site 1191061001521 metal binding site [ion binding]; metal-binding site 1191061001522 active site 1191061001523 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 1191061001524 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1191061001525 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1191061001526 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1191061001527 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1191061001528 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1191061001529 Coenzyme A binding pocket [chemical binding]; other site 1191061001530 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 1191061001531 active site 1191061001532 catalytic residues [active] 1191061001533 NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179 1191061001534 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1191061001535 putative active site [active] 1191061001536 metal binding site [ion binding]; metal-binding site 1191061001537 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1191061001538 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1191061001539 tetrameric interface [polypeptide binding]; other site 1191061001540 NAD binding site [chemical binding]; other site 1191061001541 catalytic residues [active] 1191061001542 hypothetical protein; Provisional; Region: PRK05255 1191061001543 peptidase PmbA; Provisional; Region: PRK11040 1191061001544 Cytochrome b562; Region: Cytochrom_B562; cl01546 1191061001545 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 1191061001546 Glycine-rich SFCGS; Region: Gly_rich_SFCGS; cl11916 1191061001547 conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578 1191061001548 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 1191061001549 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 1191061001550 dihydroorotase; Provisional; Region: PRK09237 1191061001551 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 1191061001552 active site 1191061001553 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 1191061001554 Protein of unknown function (DUF1341); Region: DUF1341; pfam07071 1191061001555 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1191061001556 HTH domain; Region: HTH_11; pfam08279 1191061001557 Mga helix-turn-helix domain; Region: Mga; pfam05043 1191061001558 PRD domain; Region: PRD; pfam00874 1191061001559 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1191061001560 active site 1191061001561 P-loop; other site 1191061001562 phosphorylation site [posttranslational modification] 1191061001563 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1191061001564 active site 1191061001565 phosphorylation site [posttranslational modification] 1191061001566 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 1191061001567 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 1191061001568 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1191061001569 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1191061001570 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 1191061001571 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 1191061001572 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1191061001573 FeS/SAM binding site; other site 1191061001574 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1191061001575 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1191061001576 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1191061001577 putative active site [active] 1191061001578 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1191061001579 active site 1191061001580 P-loop; other site 1191061001581 phosphorylation site [posttranslational modification] 1191061001582 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1191061001583 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1191061001584 NAD binding site [chemical binding]; other site 1191061001585 sugar binding site [chemical binding]; other site 1191061001586 divalent metal binding site [ion binding]; other site 1191061001587 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1191061001588 dimer interface [polypeptide binding]; other site 1191061001589 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1191061001590 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 1191061001591 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 1191061001592 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1191061001593 Ca binding site [ion binding]; other site 1191061001594 active site 1191061001595 catalytic site [active] 1191061001596 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1191061001597 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 1191061001598 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1191061001599 active site turn [active] 1191061001600 phosphorylation site [posttranslational modification] 1191061001601 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1191061001602 trehalose repressor; Provisional; Region: treR; PRK09492 1191061001603 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1191061001604 DNA binding site [nucleotide binding] 1191061001605 domain linker motif; other site 1191061001606 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 1191061001607 dimerization interface [polypeptide binding]; other site 1191061001608 ligand binding site [chemical binding]; other site 1191061001609 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 1191061001610 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1191061001611 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1191061001612 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1191061001613 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1191061001614 motif II; other site 1191061001615 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1191061001616 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1191061001617 homotrimer interaction site [polypeptide binding]; other site 1191061001618 putative active site [active] 1191061001619 N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211 1191061001620 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1191061001621 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 1191061001622 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 1191061001623 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 1191061001624 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 1191061001625 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1191061001626 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1191061001627 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 1191061001628 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 1191061001629 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1191061001630 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1191061001631 RNase E inhibitor protein; Provisional; Region: PRK11191 1191061001632 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 1191061001633 active site 1191061001634 dinuclear metal binding site [ion binding]; other site 1191061001635 dimerization interface [polypeptide binding]; other site 1191061001636 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1191061001637 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1191061001638 substrate binding pocket [chemical binding]; other site 1191061001639 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1191061001640 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1191061001641 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1191061001642 Coenzyme A binding pocket [chemical binding]; other site 1191061001643 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1191061001644 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1191061001645 HIGH motif; other site 1191061001646 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1191061001647 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1191061001648 active site 1191061001649 KMSKS motif; other site 1191061001650 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1191061001651 tRNA binding surface [nucleotide binding]; other site 1191061001652 anticodon binding site; other site 1191061001653 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1191061001654 DNA polymerase III subunit chi; Validated; Region: PRK05728 1191061001655 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1191061001656 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1191061001657 interface (dimer of trimers) [polypeptide binding]; other site 1191061001658 Substrate-binding/catalytic site; other site 1191061001659 Zn-binding sites [ion binding]; other site 1191061001660 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 1191061001661 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1191061001662 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 1191061001663 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1191061001664 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1191061001665 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1191061001666 Walker A motif; other site 1191061001667 ATP binding site [chemical binding]; other site 1191061001668 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 1191061001669 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1191061001670 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1191061001671 tetrameric interface [polypeptide binding]; other site 1191061001672 NAD binding site [chemical binding]; other site 1191061001673 catalytic residues [active] 1191061001674 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 1191061001675 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1191061001676 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1191061001677 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1191061001678 putative active site [active] 1191061001679 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1191061001680 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1191061001681 substrate binding site [chemical binding]; other site 1191061001682 ATP binding site [chemical binding]; other site 1191061001683 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 1191061001684 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 1191061001685 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1191061001686 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1191061001687 PYR/PP interface [polypeptide binding]; other site 1191061001688 dimer interface [polypeptide binding]; other site 1191061001689 TPP binding site [chemical binding]; other site 1191061001690 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1191061001691 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1191061001692 TPP-binding site; other site 1191061001693 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1191061001694 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1191061001695 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1191061001696 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1191061001697 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1191061001698 Metal-binding active site; metal-binding site 1191061001699 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1191061001700 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1191061001701 Metal-binding active site; metal-binding site 1191061001702 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1191061001703 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061001704 putative substrate translocation pore; other site 1191061001705 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061001706 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1191061001707 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1191061001708 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1191061001709 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1191061001710 Walker A/P-loop; other site 1191061001711 ATP binding site [chemical binding]; other site 1191061001712 Q-loop/lid; other site 1191061001713 ABC transporter signature motif; other site 1191061001714 Walker B; other site 1191061001715 D-loop; other site 1191061001716 H-loop/switch region; other site 1191061001717 TOBE domain; Region: TOBE_2; pfam08402 1191061001718 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1191061001719 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1191061001720 active site 1191061001721 metal binding site [ion binding]; metal-binding site 1191061001722 hexamer interface [polypeptide binding]; other site 1191061001723 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1191061001724 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061001725 dimer interface [polypeptide binding]; other site 1191061001726 conserved gate region; other site 1191061001727 putative PBP binding loops; other site 1191061001728 ABC-ATPase subunit interface; other site 1191061001729 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061001730 dimer interface [polypeptide binding]; other site 1191061001731 conserved gate region; other site 1191061001732 putative PBP binding loops; other site 1191061001733 ABC-ATPase subunit interface; other site 1191061001734 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1191061001735 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1191061001736 putative NAD(P) binding site [chemical binding]; other site 1191061001737 putative substrate binding site [chemical binding]; other site 1191061001738 catalytic Zn binding site [ion binding]; other site 1191061001739 structural Zn binding site [ion binding]; other site 1191061001740 dimer interface [polypeptide binding]; other site 1191061001741 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1191061001742 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191061001743 S-adenosylmethionine binding site [chemical binding]; other site 1191061001744 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1191061001745 active site 1191061001746 integrase; Provisional; Region: PRK09692 1191061001747 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1191061001748 active site 1191061001749 Int/Topo IB signature motif; other site 1191061001750 chaperone protein DnaJ; Provisional; Region: PRK14280 1191061001751 Predicted periplasmic protein [Function unknown]; Region: COG3904 1191061001752 TPR repeat; Region: TPR_11; pfam13414 1191061001753 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191061001754 binding surface 1191061001755 TPR motif; other site 1191061001756 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1191061001757 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1191061001758 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1191061001759 IS2 transposase TnpB; Reviewed; Region: PRK09409 1191061001760 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 1191061001761 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1191061001762 putative active site [active] 1191061001763 putative NTP binding site [chemical binding]; other site 1191061001764 putative nucleic acid binding site [nucleotide binding]; other site 1191061001765 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1191061001766 Integrase core domain; Region: rve; pfam00665 1191061001767 Integrase core domain; Region: rve_2; pfam13333 1191061001768 conserved hypothetical protein; Region: Lon_rel_chp; TIGR02653 1191061001769 Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337 1191061001770 TIGR02687 family protein; Region: TIGR02687 1191061001771 PglZ domain; Region: PglZ; pfam08665 1191061001772 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1191061001773 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 1191061001774 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 1191061001775 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 1191061001776 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1191061001777 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1191061001778 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1191061001779 Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea; Region: Creatinase; cd01090 1191061001780 active site 1191061001781 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1191061001782 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061001783 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1191061001784 dimerization interface [polypeptide binding]; other site 1191061001785 substrate binding pocket [chemical binding]; other site 1191061001786 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1191061001787 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1191061001788 substrate binding pocket [chemical binding]; other site 1191061001789 membrane-bound complex binding site; other site 1191061001790 hinge residues; other site 1191061001791 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061001792 ABC-ATPase subunit interface; other site 1191061001793 putative PBP binding loops; other site 1191061001794 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061001795 dimer interface [polypeptide binding]; other site 1191061001796 conserved gate region; other site 1191061001797 putative PBP binding loops; other site 1191061001798 ABC-ATPase subunit interface; other site 1191061001799 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1191061001800 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1191061001801 Walker A/P-loop; other site 1191061001802 ATP binding site [chemical binding]; other site 1191061001803 Q-loop/lid; other site 1191061001804 ABC transporter signature motif; other site 1191061001805 Walker B; other site 1191061001806 D-loop; other site 1191061001807 H-loop/switch region; other site 1191061001808 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1191061001809 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1191061001810 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1191061001811 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1191061001812 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1191061001813 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1191061001814 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1191061001815 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1191061001816 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1191061001817 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1191061001818 D-mannonate oxidoreductase; Provisional; Region: PRK15037 1191061001819 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1191061001820 Integrase core domain; Region: rve; pfam00665 1191061001821 Integrase core domain; Region: rve_3; cl15866 1191061001822 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1191061001823 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1191061001824 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1191061001825 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1191061001826 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1191061001827 PapC N-terminal domain; Region: PapC_N; pfam13954 1191061001828 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1191061001829 PapC C-terminal domain; Region: PapC_C; pfam13953 1191061001830 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1191061001831 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 1191061001832 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1191061001833 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1191061001834 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1191061001835 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 1191061001836 Domain of unknown function (DUF932); Region: DUF932; cl12129 1191061001837 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 1191061001838 Antirestriction protein; Region: Antirestrict; pfam03230 1191061001839 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1191061001840 MPN+ (JAMM) motif; other site 1191061001841 Zinc-binding site [ion binding]; other site 1191061001842 Protein of unknown function (DUF987); Region: DUF987; pfam06174 1191061001843 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 1191061001844 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 1191061001845 Methyltransferase domain; Region: Methyltransf_27; pfam13708 1191061001846 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1191061001847 non-specific DNA binding site [nucleotide binding]; other site 1191061001848 salt bridge; other site 1191061001849 sequence-specific DNA binding site [nucleotide binding]; other site 1191061001850 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1191061001851 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1191061001852 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 1191061001853 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 1191061001854 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1191061001855 active site 1191061001856 substrate binding site [chemical binding]; other site 1191061001857 Mg2+ binding site [ion binding]; other site 1191061001858 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 1191061001859 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1191061001860 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1191061001861 DNA binding site [nucleotide binding] 1191061001862 domain linker motif; other site 1191061001863 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1191061001864 dimerization interface [polypeptide binding]; other site 1191061001865 ligand binding site [chemical binding]; other site 1191061001866 Domain of unknown function (DUF336); Region: DUF336; pfam03928 1191061001867 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1191061001868 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1191061001869 inhibitor site; inhibition site 1191061001870 active site 1191061001871 dimer interface [polypeptide binding]; other site 1191061001872 catalytic residue [active] 1191061001873 flagellin modification protein A; Provisional; Region: PRK09186 1191061001874 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1191061001875 NAD(P) binding site [chemical binding]; other site 1191061001876 active site 1191061001877 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1191061001878 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1191061001879 active site pocket [active] 1191061001880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061001881 putative substrate translocation pore; other site 1191061001882 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061001883 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 1191061001884 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1191061001885 substrate binding site [chemical binding]; other site 1191061001886 trimer interface [polypeptide binding]; other site 1191061001887 Mn binding site [ion binding]; other site 1191061001888 metabolite-proton symporter; Region: 2A0106; TIGR00883 1191061001889 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061001890 putative substrate translocation pore; other site 1191061001891 outer membrane porin, OprD family; Region: OprD; pfam03573 1191061001892 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1191061001893 catalytic core [active] 1191061001894 Survival protein SurE; Region: SurE; pfam01975 1191061001895 Uncharacterized conserved protein [Function unknown]; Region: COG2850 1191061001896 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1191061001897 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1191061001898 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1191061001899 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1191061001900 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1191061001901 Walker A/P-loop; other site 1191061001902 ATP binding site [chemical binding]; other site 1191061001903 Q-loop/lid; other site 1191061001904 ABC transporter signature motif; other site 1191061001905 Walker B; other site 1191061001906 D-loop; other site 1191061001907 H-loop/switch region; other site 1191061001908 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1191061001909 Walker A/P-loop; other site 1191061001910 ATP binding site [chemical binding]; other site 1191061001911 Q-loop/lid; other site 1191061001912 ABC transporter signature motif; other site 1191061001913 Walker B; other site 1191061001914 D-loop; other site 1191061001915 H-loop/switch region; other site 1191061001916 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1191061001917 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1191061001918 HlyD family secretion protein; Region: HlyD; pfam00529 1191061001919 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1191061001920 HlyD family secretion protein; Region: HlyD_3; pfam13437 1191061001921 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1191061001922 heme-binding site [chemical binding]; other site 1191061001923 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1191061001924 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1191061001925 metal binding site [ion binding]; metal-binding site 1191061001926 active site 1191061001927 I-site; other site 1191061001928 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1191061001929 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1191061001930 active site 1191061001931 HIGH motif; other site 1191061001932 dimer interface [polypeptide binding]; other site 1191061001933 KMSKS motif; other site 1191061001934 tryptophan permease; Provisional; Region: PRK10483 1191061001935 aromatic amino acid transport protein; Region: araaP; TIGR00837 1191061001936 tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238 1191061001937 Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617 1191061001938 substrate binding site [chemical binding]; other site 1191061001939 tetramer interface [polypeptide binding]; other site 1191061001940 catalytic residue [active] 1191061001941 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1191061001942 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1191061001943 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 1191061001944 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1191061001945 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1191061001946 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1191061001947 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1191061001948 Hexamer interface [polypeptide binding]; other site 1191061001949 Hexagonal pore residue; other site 1191061001950 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 1191061001951 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1191061001952 Pyruvate formate lyase; Region: PFL; pfam02901 1191061001953 Pyruvate formate lyase; Region: PFL; pfam02901 1191061001954 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 1191061001955 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 1191061001956 dimer interface [polypeptide binding]; other site 1191061001957 active site 1191061001958 glycine loop; other site 1191061001959 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1191061001960 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 1191061001961 putative active site [active] 1191061001962 metal binding site [ion binding]; metal-binding site 1191061001963 Ethanolamine utilisation protein EutN/carboxysome; Region: EutN_CcmL; pfam03319 1191061001964 Hexamer/Pentamer interface [polypeptide binding]; other site 1191061001965 central pore; other site 1191061001966 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1191061001967 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1191061001968 putative catalytic cysteine [active] 1191061001969 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1191061001970 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1191061001971 Hexamer interface [polypeptide binding]; other site 1191061001972 Hexagonal pore residue; other site 1191061001973 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1191061001974 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1191061001975 Hexamer interface [polypeptide binding]; other site 1191061001976 Hexagonal pore residue; other site 1191061001977 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1191061001978 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1191061001979 Hexamer interface [polypeptide binding]; other site 1191061001980 Hexagonal pore residue; other site 1191061001981 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1191061001982 DNA binding site [nucleotide binding] 1191061001983 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1191061001984 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1191061001985 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1191061001986 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1191061001987 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061001988 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061001989 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461 1191061001990 putative substrate binding pocket [chemical binding]; other site 1191061001991 putative dimerization interface [polypeptide binding]; other site 1191061001992 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 1191061001993 FosA, a Fosfomycin resistance protein, catalyzes the addition of glutathione to the antibiotic fosfomycin, making it inactive; Region: FosA; cd07244 1191061001994 dimer interface [polypeptide binding]; other site 1191061001995 Mn binding site [ion binding]; other site 1191061001996 K binding site [ion binding]; other site 1191061001997 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929 1191061001998 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514 1191061001999 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1191061002000 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 1191061002001 endoribonuclease SymE; Provisional; Region: PRK13605 1191061002002 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1191061002003 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1191061002004 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1191061002005 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1191061002006 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191061002007 S-adenosylmethionine binding site [chemical binding]; other site 1191061002008 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 1191061002009 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 1191061002010 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1191061002011 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1191061002012 ATP binding site [chemical binding]; other site 1191061002013 putative Mg++ binding site [ion binding]; other site 1191061002014 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1191061002015 nucleotide binding region [chemical binding]; other site 1191061002016 ATP-binding site [chemical binding]; other site 1191061002017 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1191061002018 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1191061002019 DNA-binding site [nucleotide binding]; DNA binding site 1191061002020 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1191061002021 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061002022 homodimer interface [polypeptide binding]; other site 1191061002023 catalytic residue [active] 1191061002024 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 1191061002025 transcriptional regulator SlyA; Provisional; Region: PRK03573 1191061002026 MarR family; Region: MarR; pfam01047 1191061002027 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1191061002028 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1191061002029 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 1191061002030 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061002031 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061002032 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_5; cd08426 1191061002033 putative dimerization interface [polypeptide binding]; other site 1191061002034 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 1191061002035 Nucleoside recognition; Region: Gate; pfam07670 1191061002036 hypothetical protein; Provisional; Region: PRK10519 1191061002037 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 1191061002038 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1191061002039 metal binding site [ion binding]; metal-binding site 1191061002040 putative dimer interface [polypeptide binding]; other site 1191061002041 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 1191061002042 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 1191061002043 CoA-substrate-specific enzyme activase, putative; Region: CoA_E_activ; TIGR00241 1191061002044 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 1191061002045 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 1191061002046 Uncharacterized conserved protein (DUF2164); Region: DUF2164; cl02278 1191061002047 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 1191061002048 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1191061002049 Active Sites [active] 1191061002050 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 1191061002051 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1191061002052 ParB-like nuclease domain; Region: ParBc; pfam02195 1191061002053 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 1191061002054 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061002055 putative substrate translocation pore; other site 1191061002056 Protein of unknown function (DUF445); Region: DUF445; pfam04286 1191061002057 LysE type translocator; Region: LysE; cl00565 1191061002058 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1191061002059 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1191061002060 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061002061 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1191061002062 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1191061002063 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1191061002064 NAD(P) binding site [chemical binding]; other site 1191061002065 catalytic residues [active] 1191061002066 YfaZ precursor; Region: YfaZ; pfam07437 1191061002067 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 1191061002068 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1191061002069 P-loop, Walker A motif; other site 1191061002070 Base recognition motif; other site 1191061002071 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1191061002072 Uncharacterized small protein [Function unknown]; Region: COG2879 1191061002073 carbon starvation protein A; Provisional; Region: PRK15015 1191061002074 Carbon starvation protein CstA; Region: CstA; pfam02554 1191061002075 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1191061002076 Flavin Reductases; Region: FlaRed; cl00801 1191061002077 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 1191061002078 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1191061002079 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 1191061002080 Cupin domain; Region: Cupin_2; pfam07883 1191061002081 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061002082 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061002083 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1191061002084 putative substrate translocation pore; other site 1191061002085 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1191061002086 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 1191061002087 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 1191061002088 putative substrate binding pocket [chemical binding]; other site 1191061002089 trimer interface [polypeptide binding]; other site 1191061002090 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 1191061002091 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1191061002092 putative active site [active] 1191061002093 putative metal binding site [ion binding]; other site 1191061002094 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 1191061002095 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 1191061002096 NAD binding site [chemical binding]; other site 1191061002097 catalytic residues [active] 1191061002098 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1191061002099 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1191061002100 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 1191061002101 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1191061002102 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 1191061002103 dimer interface [polypeptide binding]; other site 1191061002104 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1191061002105 active site 1191061002106 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1191061002107 substrate binding site [chemical binding]; other site 1191061002108 catalytic residue [active] 1191061002109 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 1191061002110 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1191061002111 active site 1191061002112 putative substrate binding pocket [chemical binding]; other site 1191061002113 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1191061002114 homotrimer interaction site [polypeptide binding]; other site 1191061002115 putative active site [active] 1191061002116 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1191061002117 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1191061002118 Na binding site [ion binding]; other site 1191061002119 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 1191061002120 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 1191061002121 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 1191061002122 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1191061002123 active site 1191061002124 intersubunit interface [polypeptide binding]; other site 1191061002125 catalytic residue [active] 1191061002126 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1191061002127 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1191061002128 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1191061002129 putative active site [active] 1191061002130 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1191061002131 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1191061002132 Coenzyme A binding pocket [chemical binding]; other site 1191061002133 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1191061002134 Coenzyme A binding pocket [chemical binding]; other site 1191061002135 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1191061002136 Coenzyme A binding pocket [chemical binding]; other site 1191061002137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061002138 D-galactonate transporter; Region: 2A0114; TIGR00893 1191061002139 putative substrate translocation pore; other site 1191061002140 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1191061002141 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1191061002142 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1191061002143 DNA-binding site [nucleotide binding]; DNA binding site 1191061002144 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1191061002145 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1191061002146 altronate oxidoreductase; Provisional; Region: PRK03643 1191061002147 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1191061002148 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1191061002149 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1191061002150 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191061002151 Walker A motif; other site 1191061002152 ATP binding site [chemical binding]; other site 1191061002153 Walker B motif; other site 1191061002154 arginine finger; other site 1191061002155 Transcriptional antiterminator [Transcription]; Region: COG3933 1191061002156 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1191061002157 active pocket/dimerization site; other site 1191061002158 active site 1191061002159 phosphorylation site [posttranslational modification] 1191061002160 PRD domain; Region: PRD; pfam00874 1191061002161 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1191061002162 active pocket/dimerization site; other site 1191061002163 active site 1191061002164 phosphorylation site [posttranslational modification] 1191061002165 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1191061002166 active site 1191061002167 phosphorylation site [posttranslational modification] 1191061002168 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 1191061002169 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 1191061002170 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1191061002171 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1191061002172 dimer interface [polypeptide binding]; other site 1191061002173 active site 1191061002174 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1191061002175 dimer interface [polypeptide binding]; other site 1191061002176 active site 1191061002177 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1191061002178 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 1191061002179 putative active site [active] 1191061002180 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1191061002181 hypothetical protein; Provisional; Region: PRK09956 1191061002182 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1191061002183 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 1191061002184 phosphoglycerol transferase I; Provisional; Region: PRK03776 1191061002185 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1191061002186 hypothetical protein; Provisional; Region: PRK11667 1191061002187 DNA replication protein DnaC; Validated; Region: PRK07952 1191061002188 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191061002189 Walker A motif; other site 1191061002190 ATP binding site [chemical binding]; other site 1191061002191 Walker B motif; other site 1191061002192 primosomal protein DnaI; Provisional; Region: PRK02854 1191061002193 hypothetical protein; Provisional; Region: PRK09917 1191061002194 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1191061002195 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1191061002196 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 1191061002197 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1191061002198 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 1191061002199 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061002200 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1191061002201 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1191061002202 DNA binding residues [nucleotide binding] 1191061002203 dimerization interface [polypeptide binding]; other site 1191061002204 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 1191061002205 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1191061002206 DNA binding residues [nucleotide binding] 1191061002207 dimerization interface [polypeptide binding]; other site 1191061002208 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1191061002209 putative deacylase active site [active] 1191061002210 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1191061002211 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1191061002212 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 1191061002213 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1191061002214 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1191061002215 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1191061002216 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1191061002217 metal binding site [ion binding]; metal-binding site 1191061002218 active site 1191061002219 I-site; other site 1191061002220 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 1191061002221 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 1191061002222 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 1191061002223 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191061002224 S-adenosylmethionine binding site [chemical binding]; other site 1191061002225 DNA polymerase III subunit psi; Validated; Region: PRK06856 1191061002226 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 1191061002227 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1191061002228 Coenzyme A binding pocket [chemical binding]; other site 1191061002229 dUMP phosphatase; Provisional; Region: PRK09449 1191061002230 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1191061002231 motif II; other site 1191061002232 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1191061002233 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1191061002234 G1 box; other site 1191061002235 putative GEF interaction site [polypeptide binding]; other site 1191061002236 GTP/Mg2+ binding site [chemical binding]; other site 1191061002237 Switch I region; other site 1191061002238 G2 box; other site 1191061002239 G3 box; other site 1191061002240 Switch II region; other site 1191061002241 G4 box; other site 1191061002242 G5 box; other site 1191061002243 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1191061002244 periplasmic protein; Provisional; Region: PRK10568 1191061002245 BON domain; Region: BON; pfam04972 1191061002246 BON domain; Region: BON; pfam04972 1191061002247 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1191061002248 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1191061002249 active site 1191061002250 nucleophile elbow; other site 1191061002251 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1191061002252 active site 1191061002253 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1191061002254 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1191061002255 Nucleoside recognition; Region: Gate; pfam07670 1191061002256 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1191061002257 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1191061002258 intersubunit interface [polypeptide binding]; other site 1191061002259 active site 1191061002260 catalytic residue [active] 1191061002261 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1191061002262 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1191061002263 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1191061002264 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 1191061002265 phosphopentomutase; Provisional; Region: PRK05362 1191061002266 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1191061002267 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1191061002268 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1191061002269 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 1191061002270 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1191061002271 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1191061002272 hypothetical protein; Provisional; Region: PRK11246 1191061002273 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 1191061002274 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1191061002275 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1191061002276 motif II; other site 1191061002277 DNA repair protein RadA; Region: sms; TIGR00416 1191061002278 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1191061002279 Walker A motif/ATP binding site; other site 1191061002280 ATP binding site [chemical binding]; other site 1191061002281 Walker B motif; other site 1191061002282 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1191061002283 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1191061002284 non-specific DNA binding site [nucleotide binding]; other site 1191061002285 salt bridge; other site 1191061002286 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 1191061002287 sequence-specific DNA binding site [nucleotide binding]; other site 1191061002288 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 1191061002289 active site 1191061002290 (T/H)XGH motif; other site 1191061002291 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1191061002292 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1191061002293 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1191061002294 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1191061002295 ABC transporter; Region: ABC_tran_2; pfam12848 1191061002296 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1191061002297 lytic murein transglycosylase; Provisional; Region: PRK11619 1191061002298 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1191061002299 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1191061002300 catalytic residue [active] 1191061002301 Trp operon repressor; Provisional; Region: PRK01381 1191061002302 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 1191061002303 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1191061002304 catalytic core [active] 1191061002305 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 1191061002306 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061002307 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 1191061002308 hypothetical protein; Provisional; Region: PRK10756 1191061002309 CreA protein; Region: CreA; pfam05981 1191061002310 DNA-binding response regulator CreB; Provisional; Region: PRK11083 1191061002311 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191061002312 active site 1191061002313 phosphorylation site [posttranslational modification] 1191061002314 intermolecular recognition site; other site 1191061002315 dimerization interface [polypeptide binding]; other site 1191061002316 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1191061002317 DNA binding site [nucleotide binding] 1191061002318 sensory histidine kinase CreC; Provisional; Region: PRK11100 1191061002319 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1191061002320 dimerization interface [polypeptide binding]; other site 1191061002321 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191061002322 dimer interface [polypeptide binding]; other site 1191061002323 phosphorylation site [posttranslational modification] 1191061002324 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191061002325 ATP binding site [chemical binding]; other site 1191061002326 Mg2+ binding site [ion binding]; other site 1191061002327 G-X-G motif; other site 1191061002328 Inner membrane protein CreD; Region: CreD; cl01844 1191061002329 two-component response regulator; Provisional; Region: PRK11173 1191061002330 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191061002331 active site 1191061002332 phosphorylation site [posttranslational modification] 1191061002333 intermolecular recognition site; other site 1191061002334 dimerization interface [polypeptide binding]; other site 1191061002335 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1191061002336 DNA binding site [nucleotide binding] 1191061002337 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 1191061002338 putative RNA methyltransferase; Provisional; Region: PRK10433 1191061002339 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 1191061002340 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 1191061002341 putative aspartate binding site [chemical binding]; other site 1191061002342 putative catalytic residues [active] 1191061002343 putative nucleotide binding site [chemical binding]; other site 1191061002344 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 1191061002345 dimer interface [polypeptide binding]; other site 1191061002346 putative threonine allosteric regulatory site; other site 1191061002347 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 1191061002348 putative threonine allosteric regulatory site; other site 1191061002349 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1191061002350 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1191061002351 homoserine kinase; Provisional; Region: PRK01212 1191061002352 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1191061002353 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1191061002354 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1191061002355 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1191061002356 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061002357 catalytic residue [active] 1191061002358 hypothetical protein; Validated; Region: PRK02101 1191061002359 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1191061002360 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1191061002361 transaldolase-like protein; Provisional; Region: PTZ00411 1191061002362 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1191061002363 active site 1191061002364 dimer interface [polypeptide binding]; other site 1191061002365 catalytic residue [active] 1191061002366 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1191061002367 MPT binding site; other site 1191061002368 trimer interface [polypeptide binding]; other site 1191061002369 metabolite-proton symporter; Region: 2A0106; TIGR00883 1191061002370 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061002371 putative substrate translocation pore; other site 1191061002372 hypothetical protein; Provisional; Region: PRK10659 1191061002373 hypothetical protein; Provisional; Region: PRK10236 1191061002374 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 1191061002375 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 1191061002376 hypothetical protein; Provisional; Region: PRK10154 1191061002377 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1191061002378 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1191061002379 nucleotide binding site [chemical binding]; other site 1191061002380 chaperone protein DnaJ; Provisional; Region: PRK10767 1191061002381 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1191061002382 HSP70 interaction site [polypeptide binding]; other site 1191061002383 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1191061002384 substrate binding site [polypeptide binding]; other site 1191061002385 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1191061002386 Zn binding sites [ion binding]; other site 1191061002387 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1191061002388 dimer interface [polypeptide binding]; other site 1191061002389 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061002390 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1191061002391 dimerization interface [polypeptide binding]; other site 1191061002392 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 1191061002393 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 1191061002394 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 1191061002395 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 1191061002396 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 1191061002397 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 1191061002398 active site 1191061002399 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 1191061002400 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1191061002401 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1191061002402 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 1191061002403 Helix-turn-helix domain; Region: HTH_36; pfam13730 1191061002404 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 1191061002405 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 1191061002406 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061002407 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 1191061002408 putative dimerization interface [polypeptide binding]; other site 1191061002409 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1191061002410 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1191061002411 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1191061002412 active site 1191061002413 Riboflavin kinase; Region: Flavokinase; smart00904 1191061002414 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1191061002415 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1191061002416 active site 1191061002417 HIGH motif; other site 1191061002418 nucleotide binding site [chemical binding]; other site 1191061002419 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1191061002420 active site 1191061002421 KMSKS motif; other site 1191061002422 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1191061002423 tRNA binding surface [nucleotide binding]; other site 1191061002424 anticodon binding site; other site 1191061002425 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1191061002426 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1191061002427 lipoprotein signal peptidase; Provisional; Region: PRK14787 1191061002428 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1191061002429 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1191061002430 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1191061002431 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1191061002432 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1191061002433 active site 1191061002434 tetramer interface [polypeptide binding]; other site 1191061002435 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061002436 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061002437 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1191061002438 putative dimerization interface [polypeptide binding]; other site 1191061002439 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 1191061002440 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1191061002441 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1191061002442 transmembrane helices; other site 1191061002443 Citrate transporter; Region: CitMHS; pfam03600 1191061002444 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1191061002445 transmembrane helices; other site 1191061002446 putative hydratase; Provisional; Region: PRK11413 1191061002447 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1191061002448 substrate binding site [chemical binding]; other site 1191061002449 ligand binding site [chemical binding]; other site 1191061002450 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 1191061002451 substrate binding site [chemical binding]; other site 1191061002452 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061002453 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061002454 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1191061002455 putative effector binding pocket; other site 1191061002456 dimerization interface [polypeptide binding]; other site 1191061002457 alanine-tRNA ligase; Region: PLN02961 1191061002458 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 1191061002459 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1191061002460 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191061002461 active site 1191061002462 phosphorylation site [posttranslational modification] 1191061002463 intermolecular recognition site; other site 1191061002464 dimerization interface [polypeptide binding]; other site 1191061002465 Transcriptional regulator; Region: CitT; pfam12431 1191061002466 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1191061002467 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191061002468 putative active site [active] 1191061002469 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191061002470 ATP binding site [chemical binding]; other site 1191061002471 Mg2+ binding site [ion binding]; other site 1191061002472 G-X-G motif; other site 1191061002473 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 1191061002474 oxaloacetate decarboxylase; Provisional; Region: PRK14040 1191061002475 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1191061002476 active site 1191061002477 catalytic residues [active] 1191061002478 metal binding site [ion binding]; metal-binding site 1191061002479 homodimer binding site [polypeptide binding]; other site 1191061002480 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1191061002481 carboxyltransferase (CT) interaction site; other site 1191061002482 biotinylation site [posttranslational modification]; other site 1191061002483 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 1191061002484 Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493 1191061002485 citrate lyase subunit gamma; Provisional; Region: PRK13253 1191061002486 citrate lyase, beta subunit; Region: citE; TIGR01588 1191061002487 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 1191061002488 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1191061002489 triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125 1191061002490 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 1191061002491 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1191061002492 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1191061002493 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1191061002494 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1191061002495 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1191061002496 catalytic site [active] 1191061002497 subunit interface [polypeptide binding]; other site 1191061002498 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1191061002499 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1191061002500 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1191061002501 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1191061002502 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1191061002503 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1191061002504 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1191061002505 IMP binding site; other site 1191061002506 dimer interface [polypeptide binding]; other site 1191061002507 interdomain contacts; other site 1191061002508 partial ornithine binding site; other site 1191061002509 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1191061002510 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 1191061002511 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 1191061002512 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1191061002513 TrkA-N domain; Region: TrkA_N; pfam02254 1191061002514 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1191061002515 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1191061002516 folate binding site [chemical binding]; other site 1191061002517 NADP+ binding site [chemical binding]; other site 1191061002518 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 1191061002519 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 1191061002520 active site 1191061002521 metal binding site [ion binding]; metal-binding site 1191061002522 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 1191061002523 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1191061002524 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1191061002525 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 1191061002526 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1191061002527 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 1191061002528 SurA N-terminal domain; Region: SurA_N; pfam09312 1191061002529 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1191061002530 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1191061002531 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 1191061002532 OstA-like protein; Region: OstA; pfam03968 1191061002533 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1191061002534 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 1191061002535 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 1191061002536 putative metal binding site [ion binding]; other site 1191061002537 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1191061002538 HSP70 interaction site [polypeptide binding]; other site 1191061002539 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1191061002540 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191061002541 active site 1191061002542 phosphorylation site [posttranslational modification] 1191061002543 intermolecular recognition site; other site 1191061002544 dimerization interface [polypeptide binding]; other site 1191061002545 Transcriptional regulator; Region: CitT; pfam12431 1191061002546 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1191061002547 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1191061002548 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191061002549 putative active site [active] 1191061002550 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191061002551 ATP binding site [chemical binding]; other site 1191061002552 Mg2+ binding site [ion binding]; other site 1191061002553 G-X-G motif; other site 1191061002554 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 1191061002555 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802 1191061002556 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1191061002557 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1191061002558 active site 1191061002559 ATP-dependent helicase HepA; Validated; Region: PRK04914 1191061002560 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1191061002561 ATP binding site [chemical binding]; other site 1191061002562 putative Mg++ binding site [ion binding]; other site 1191061002563 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1191061002564 nucleotide binding region [chemical binding]; other site 1191061002565 ATP-binding site [chemical binding]; other site 1191061002566 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1191061002567 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1191061002568 intersubunit interface [polypeptide binding]; other site 1191061002569 active site 1191061002570 Zn2+ binding site [ion binding]; other site 1191061002571 L-arabinose isomerase; Provisional; Region: PRK02929 1191061002572 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 1191061002573 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 1191061002574 trimer interface [polypeptide binding]; other site 1191061002575 putative substrate binding site [chemical binding]; other site 1191061002576 putative metal binding site [ion binding]; other site 1191061002577 ribulokinase; Provisional; Region: PRK04123 1191061002578 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1191061002579 N- and C-terminal domain interface [polypeptide binding]; other site 1191061002580 active site 1191061002581 MgATP binding site [chemical binding]; other site 1191061002582 catalytic site [active] 1191061002583 metal binding site [ion binding]; metal-binding site 1191061002584 carbohydrate binding site [chemical binding]; other site 1191061002585 homodimer interface [polypeptide binding]; other site 1191061002586 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 1191061002587 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1191061002588 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061002589 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061002590 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1191061002591 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1191061002592 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 1191061002593 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 1191061002594 Walker A/P-loop; other site 1191061002595 ATP binding site [chemical binding]; other site 1191061002596 Q-loop/lid; other site 1191061002597 ABC transporter signature motif; other site 1191061002598 Walker B; other site 1191061002599 D-loop; other site 1191061002600 H-loop/switch region; other site 1191061002601 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 1191061002602 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061002603 dimer interface [polypeptide binding]; other site 1191061002604 conserved gate region; other site 1191061002605 putative PBP binding loops; other site 1191061002606 ABC-ATPase subunit interface; other site 1191061002607 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061002608 dimer interface [polypeptide binding]; other site 1191061002609 conserved gate region; other site 1191061002610 putative PBP binding loops; other site 1191061002611 ABC-ATPase subunit interface; other site 1191061002612 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 1191061002613 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 1191061002614 transcriptional regulator SgrR; Provisional; Region: PRK13626 1191061002615 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1191061002616 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 1191061002617 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061002618 sugar efflux transporter; Region: 2A0120; TIGR00899 1191061002619 putative substrate translocation pore; other site 1191061002620 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061002621 D-galactonate transporter; Region: 2A0114; TIGR00893 1191061002622 putative substrate translocation pore; other site 1191061002623 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061002624 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061002625 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1191061002626 putative dimerization interface [polypeptide binding]; other site 1191061002627 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1191061002628 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1191061002629 active site 1191061002630 catalytic residue [active] 1191061002631 dimer interface [polypeptide binding]; other site 1191061002632 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061002633 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1191061002634 putative substrate translocation pore; other site 1191061002635 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 1191061002636 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1191061002637 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1191061002638 shikimate binding site; other site 1191061002639 NAD(P) binding site [chemical binding]; other site 1191061002640 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1191061002641 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 1191061002642 active site 1191061002643 FMN binding site [chemical binding]; other site 1191061002644 substrate binding site [chemical binding]; other site 1191061002645 putative catalytic residue [active] 1191061002646 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1191061002647 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1191061002648 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1191061002649 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1191061002650 substrate binding site [chemical binding]; other site 1191061002651 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1191061002652 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1191061002653 substrate binding site [chemical binding]; other site 1191061002654 ligand binding site [chemical binding]; other site 1191061002655 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1191061002656 tartrate dehydrogenase; Region: TTC; TIGR02089 1191061002657 2-isopropylmalate synthase; Validated; Region: PRK00915 1191061002658 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1191061002659 active site 1191061002660 catalytic residues [active] 1191061002661 metal binding site [ion binding]; metal-binding site 1191061002662 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1191061002663 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 1191061002664 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061002665 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 1191061002666 putative substrate binding pocket [chemical binding]; other site 1191061002667 putative dimerization interface [polypeptide binding]; other site 1191061002668 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 1191061002669 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1191061002670 PYR/PP interface [polypeptide binding]; other site 1191061002671 dimer interface [polypeptide binding]; other site 1191061002672 TPP binding site [chemical binding]; other site 1191061002673 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1191061002674 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1191061002675 TPP-binding site [chemical binding]; other site 1191061002676 dimer interface [polypeptide binding]; other site 1191061002677 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1191061002678 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1191061002679 putative valine binding site [chemical binding]; other site 1191061002680 dimer interface [polypeptide binding]; other site 1191061002681 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1191061002682 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 1191061002683 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1191061002684 DNA binding site [nucleotide binding] 1191061002685 domain linker motif; other site 1191061002686 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1191061002687 dimerization interface [polypeptide binding]; other site 1191061002688 ligand binding site [chemical binding]; other site 1191061002689 mraZ protein; Region: TIGR00242 1191061002690 MraZ protein; Region: MraZ; pfam02381 1191061002691 MraZ protein; Region: MraZ; pfam02381 1191061002692 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 1191061002693 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1191061002694 cell division protein FtsL; Provisional; Region: PRK10772 1191061002695 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 1191061002696 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1191061002697 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1191061002698 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1191061002699 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1191061002700 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1191061002701 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1191061002702 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 1191061002703 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1191061002704 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1191061002705 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1191061002706 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1191061002707 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1191061002708 Mg++ binding site [ion binding]; other site 1191061002709 putative catalytic motif [active] 1191061002710 putative substrate binding site [chemical binding]; other site 1191061002711 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 1191061002712 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1191061002713 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1191061002714 cell division protein FtsW; Provisional; Region: PRK10774 1191061002715 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1191061002716 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1191061002717 active site 1191061002718 homodimer interface [polypeptide binding]; other site 1191061002719 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1191061002720 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1191061002721 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1191061002722 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1191061002723 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1191061002724 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1191061002725 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1191061002726 cell division protein FtsQ; Provisional; Region: PRK10775 1191061002727 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1191061002728 Cell division protein FtsQ; Region: FtsQ; pfam03799 1191061002729 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 1191061002730 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1191061002731 Cell division protein FtsA; Region: FtsA; pfam14450 1191061002732 cell division protein FtsZ; Validated; Region: PRK09330 1191061002733 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1191061002734 nucleotide binding site [chemical binding]; other site 1191061002735 SulA interaction site; other site 1191061002736 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 1191061002737 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1191061002738 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1191061002739 SecA regulator SecM; Provisional; Region: PRK02943 1191061002740 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1191061002741 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1191061002742 SEC-C motif; Region: SEC-C; pfam02810 1191061002743 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1191061002744 active site 1191061002745 8-oxo-dGMP binding site [chemical binding]; other site 1191061002746 nudix motif; other site 1191061002747 metal binding site [ion binding]; metal-binding site 1191061002748 DNA gyrase inhibitor; Reviewed; Region: PRK00418 1191061002749 hypothetical protein; Provisional; Region: PRK05287 1191061002750 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1191061002751 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1191061002752 CoA-binding site [chemical binding]; other site 1191061002753 ATP-binding [chemical binding]; other site 1191061002754 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 1191061002755 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1191061002756 active site 1191061002757 type IV pilin biogenesis protein; Provisional; Region: PRK10573 1191061002758 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1191061002759 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1191061002760 hypothetical protein; Provisional; Region: PRK10436 1191061002761 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1191061002762 Walker A motif; other site 1191061002763 ATP binding site [chemical binding]; other site 1191061002764 Walker B motif; other site 1191061002765 putative major pilin subunit; Provisional; Region: PRK10574 1191061002766 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1191061002767 Pilin (bacterial filament); Region: Pilin; pfam00114 1191061002768 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 1191061002769 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1191061002770 dimerization interface [polypeptide binding]; other site 1191061002771 active site 1191061002772 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1191061002773 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1191061002774 amidase catalytic site [active] 1191061002775 Zn binding residues [ion binding]; other site 1191061002776 substrate binding site [chemical binding]; other site 1191061002777 regulatory protein AmpE; Provisional; Region: PRK10987 1191061002778 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 1191061002779 active site 1191061002780 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1191061002781 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061002782 putative substrate translocation pore; other site 1191061002783 aromatic amino acid transporter; Provisional; Region: PRK10238 1191061002784 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 1191061002785 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1191061002786 DNA-binding site [nucleotide binding]; DNA binding site 1191061002787 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1191061002788 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1191061002789 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1191061002790 dimer interface [polypeptide binding]; other site 1191061002791 TPP-binding site [chemical binding]; other site 1191061002792 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 1191061002793 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1191061002794 E3 interaction surface; other site 1191061002795 lipoyl attachment site [posttranslational modification]; other site 1191061002796 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1191061002797 E3 interaction surface; other site 1191061002798 lipoyl attachment site [posttranslational modification]; other site 1191061002799 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1191061002800 E3 interaction surface; other site 1191061002801 lipoyl attachment site [posttranslational modification]; other site 1191061002802 e3 binding domain; Region: E3_binding; pfam02817 1191061002803 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1191061002804 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1191061002805 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1191061002806 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1191061002807 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1191061002808 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 1191061002809 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 1191061002810 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 1191061002811 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 1191061002812 substrate binding site [chemical binding]; other site 1191061002813 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 1191061002814 substrate binding site [chemical binding]; other site 1191061002815 ligand binding site [chemical binding]; other site 1191061002816 hypothetical protein; Provisional; Region: PRK05248 1191061002817 2-keto-3-deoxygluconate permease; Provisional; Region: PRK12460 1191061002818 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1191061002819 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1191061002820 4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371 1191061002821 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1191061002822 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1191061002823 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1191061002824 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 1191061002825 spermidine synthase; Provisional; Region: PRK00811 1191061002826 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191061002827 S-adenosylmethionine binding site [chemical binding]; other site 1191061002828 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1191061002829 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1191061002830 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1191061002831 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 1191061002832 multicopper oxidase; Provisional; Region: PRK10965 1191061002833 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1191061002834 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1191061002835 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1191061002836 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1191061002837 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1191061002838 Trp docking motif [polypeptide binding]; other site 1191061002839 putative active site [active] 1191061002840 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1191061002841 active site 1191061002842 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 1191061002843 active site clefts [active] 1191061002844 zinc binding site [ion binding]; other site 1191061002845 dimer interface [polypeptide binding]; other site 1191061002846 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1191061002847 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1191061002848 Walker A/P-loop; other site 1191061002849 ATP binding site [chemical binding]; other site 1191061002850 Q-loop/lid; other site 1191061002851 ABC transporter signature motif; other site 1191061002852 Walker B; other site 1191061002853 D-loop; other site 1191061002854 H-loop/switch region; other site 1191061002855 inner membrane transport permease; Provisional; Region: PRK15066 1191061002856 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1191061002857 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1191061002858 active pocket/dimerization site; other site 1191061002859 active site 1191061002860 phosphorylation site [posttranslational modification] 1191061002861 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 1191061002862 putative active site [active] 1191061002863 putative metal binding site [ion binding]; other site 1191061002864 Fimbrial protein; Region: Fimbrial; cl01416 1191061002865 Fimbrial protein; Region: Fimbrial; cl01416 1191061002866 putative fimbrial protein StaE; Provisional; Region: PRK15263 1191061002867 Fimbrial protein; Region: Fimbrial; cl01416 1191061002868 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 1191061002869 PapC N-terminal domain; Region: PapC_N; pfam13954 1191061002870 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1191061002871 PapC C-terminal domain; Region: PapC_C; pfam13953 1191061002872 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1191061002873 Fimbrial protein; Region: Fimbrial; cl01416 1191061002874 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1191061002875 tetramerization interface [polypeptide binding]; other site 1191061002876 active site 1191061002877 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1191061002878 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1191061002879 active site 1191061002880 ATP-binding site [chemical binding]; other site 1191061002881 pantoate-binding site; other site 1191061002882 HXXH motif; other site 1191061002883 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1191061002884 oligomerization interface [polypeptide binding]; other site 1191061002885 active site 1191061002886 metal binding site [ion binding]; metal-binding site 1191061002887 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1191061002888 catalytic center binding site [active] 1191061002889 ATP binding site [chemical binding]; other site 1191061002890 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 1191061002891 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1191061002892 active site 1191061002893 NTP binding site [chemical binding]; other site 1191061002894 metal binding triad [ion binding]; metal-binding site 1191061002895 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1191061002896 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 1191061002897 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1191061002898 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 1191061002899 active site 1191061002900 HIGH motif; other site 1191061002901 nucleotide binding site [chemical binding]; other site 1191061002902 KMSKS motif; other site 1191061002903 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 1191061002904 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1191061002905 2'-5' RNA ligase; Provisional; Region: PRK15124 1191061002906 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1191061002907 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1191061002908 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 1191061002909 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1191061002910 ATP binding site [chemical binding]; other site 1191061002911 putative Mg++ binding site [ion binding]; other site 1191061002912 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1191061002913 nucleotide binding region [chemical binding]; other site 1191061002914 ATP-binding site [chemical binding]; other site 1191061002915 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1191061002916 Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203 1191061002917 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1191061002918 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1191061002919 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1191061002920 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 1191061002921 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 1191061002922 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 1191061002923 type II secretion system protein I; Region: gspI; TIGR01707 1191061002924 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 1191061002925 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 1191061002926 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1191061002927 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1191061002928 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1191061002929 type II secretion system protein F; Region: GspF; TIGR02120 1191061002930 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1191061002931 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1191061002932 type II secretion system protein E; Region: type_II_gspE; TIGR02533 1191061002933 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1191061002934 Walker A motif; other site 1191061002935 ATP binding site [chemical binding]; other site 1191061002936 Walker B motif; other site 1191061002937 type II secretion system protein D; Region: type_II_gspD; TIGR02517 1191061002938 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1191061002939 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1191061002940 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1191061002941 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1191061002942 type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713 1191061002943 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 1191061002944 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1191061002945 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 1191061002946 carbohydrate binding site [chemical binding]; other site 1191061002947 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 1191061002948 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1191061002949 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1191061002950 Ca binding site [ion binding]; other site 1191061002951 active site 1191061002952 catalytic site [active] 1191061002953 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 1191061002954 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 1191061002955 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 1191061002956 Transglycosylase; Region: Transgly; pfam00912 1191061002957 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1191061002958 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1191061002959 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1191061002960 N-terminal plug; other site 1191061002961 ligand-binding site [chemical binding]; other site 1191061002962 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 1191061002963 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1191061002964 Walker A/P-loop; other site 1191061002965 ATP binding site [chemical binding]; other site 1191061002966 Q-loop/lid; other site 1191061002967 ABC transporter signature motif; other site 1191061002968 Walker B; other site 1191061002969 D-loop; other site 1191061002970 H-loop/switch region; other site 1191061002971 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1191061002972 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1191061002973 siderophore binding site; other site 1191061002974 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1191061002975 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1191061002976 ABC-ATPase subunit interface; other site 1191061002977 dimer interface [polypeptide binding]; other site 1191061002978 putative PBP binding regions; other site 1191061002979 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1191061002980 ABC-ATPase subunit interface; other site 1191061002981 dimer interface [polypeptide binding]; other site 1191061002982 putative PBP binding regions; other site 1191061002983 hypothetical protein; Provisional; Region: PRK09956 1191061002984 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1191061002985 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 1191061002986 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1191061002987 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1191061002988 inhibitor-cofactor binding pocket; inhibition site 1191061002989 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061002990 catalytic residue [active] 1191061002991 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1191061002992 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1191061002993 Cl- selectivity filter; other site 1191061002994 Cl- binding residues [ion binding]; other site 1191061002995 pore gating glutamate residue; other site 1191061002996 dimer interface [polypeptide binding]; other site 1191061002997 H+/Cl- coupling transport residue; other site 1191061002998 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 1191061002999 hypothetical protein; Provisional; Region: PRK10578 1191061003000 UPF0126 domain; Region: UPF0126; pfam03458 1191061003001 UPF0126 domain; Region: UPF0126; pfam03458 1191061003002 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 1191061003003 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 1191061003004 cobalamin binding residues [chemical binding]; other site 1191061003005 putative BtuC binding residues; other site 1191061003006 dimer interface [polypeptide binding]; other site 1191061003007 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1191061003008 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1191061003009 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 1191061003010 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1191061003011 Zn2+ binding site [ion binding]; other site 1191061003012 Mg2+ binding site [ion binding]; other site 1191061003013 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1191061003014 serine endoprotease; Provisional; Region: PRK10942 1191061003015 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1191061003016 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1191061003017 protein binding site [polypeptide binding]; other site 1191061003018 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1191061003019 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 1191061003020 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1191061003021 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1191061003022 Viral enhancin protein; Region: Enhancin; pfam03272 1191061003023 hypothetical protein; Provisional; Region: PRK13677 1191061003024 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 1191061003025 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1191061003026 trimer interface [polypeptide binding]; other site 1191061003027 active site 1191061003028 substrate binding site [chemical binding]; other site 1191061003029 CoA binding site [chemical binding]; other site 1191061003030 PII uridylyl-transferase; Provisional; Region: PRK05007 1191061003031 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1191061003032 metal binding triad; other site 1191061003033 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1191061003034 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1191061003035 Zn2+ binding site [ion binding]; other site 1191061003036 Mg2+ binding site [ion binding]; other site 1191061003037 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 1191061003038 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1191061003039 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1191061003040 active site 1191061003041 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1191061003042 rRNA interaction site [nucleotide binding]; other site 1191061003043 S8 interaction site; other site 1191061003044 putative laminin-1 binding site; other site 1191061003045 elongation factor Ts; Provisional; Region: tsf; PRK09377 1191061003046 UBA/TS-N domain; Region: UBA; pfam00627 1191061003047 Elongation factor TS; Region: EF_TS; pfam00889 1191061003048 Elongation factor TS; Region: EF_TS; pfam00889 1191061003049 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1191061003050 putative nucleotide binding site [chemical binding]; other site 1191061003051 uridine monophosphate binding site [chemical binding]; other site 1191061003052 homohexameric interface [polypeptide binding]; other site 1191061003053 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1191061003054 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1191061003055 hinge region; other site 1191061003056 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1191061003057 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1191061003058 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1191061003059 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1191061003060 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1191061003061 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1191061003062 catalytic residue [active] 1191061003063 putative FPP diphosphate binding site; other site 1191061003064 putative FPP binding hydrophobic cleft; other site 1191061003065 dimer interface [polypeptide binding]; other site 1191061003066 putative IPP diphosphate binding site; other site 1191061003067 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 1191061003068 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1191061003069 zinc metallopeptidase RseP; Provisional; Region: PRK10779 1191061003070 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1191061003071 active site 1191061003072 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1191061003073 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1191061003074 protein binding site [polypeptide binding]; other site 1191061003075 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1191061003076 putative substrate binding region [chemical binding]; other site 1191061003077 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 1191061003078 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1191061003079 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1191061003080 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1191061003081 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1191061003082 Surface antigen; Region: Bac_surface_Ag; pfam01103 1191061003083 periplasmic chaperone; Provisional; Region: PRK10780 1191061003084 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1191061003085 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1191061003086 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1191061003087 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1191061003088 trimer interface [polypeptide binding]; other site 1191061003089 active site 1191061003090 UDP-GlcNAc binding site [chemical binding]; other site 1191061003091 lipid binding site [chemical binding]; lipid-binding site 1191061003092 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1191061003093 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1191061003094 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1191061003095 active site 1191061003096 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1191061003097 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1191061003098 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1191061003099 RNA/DNA hybrid binding site [nucleotide binding]; other site 1191061003100 active site 1191061003101 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1191061003102 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1191061003103 putative active site [active] 1191061003104 putative PHP Thumb interface [polypeptide binding]; other site 1191061003105 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1191061003106 generic binding surface II; other site 1191061003107 generic binding surface I; other site 1191061003108 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1191061003109 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1191061003110 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 1191061003111 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 1191061003112 putative sugar binding site [chemical binding]; other site 1191061003113 catalytic residues [active] 1191061003114 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 1191061003115 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1191061003116 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1191061003117 putative metal binding site [ion binding]; other site 1191061003118 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 1191061003119 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1191061003120 Ligand Binding Site [chemical binding]; other site 1191061003121 TilS substrate binding domain; Region: TilS; pfam09179 1191061003122 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 1191061003123 Rho-binding antiterminator; Provisional; Region: PRK11625 1191061003124 Uncharacterized protein family (UPF0253); Region: UPF0253; cl11640 1191061003125 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 1191061003126 hypothetical protein; Provisional; Region: PRK09256 1191061003127 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1191061003128 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 1191061003129 NlpE N-terminal domain; Region: NlpE; pfam04170 1191061003130 hypothetical protein; Provisional; Region: PRK11479 1191061003131 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 1191061003132 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1191061003133 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1191061003134 dimer interface [polypeptide binding]; other site 1191061003135 motif 1; other site 1191061003136 active site 1191061003137 motif 2; other site 1191061003138 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1191061003139 putative deacylase active site [active] 1191061003140 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1191061003141 active site 1191061003142 motif 3; other site 1191061003143 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1191061003144 anticodon binding site; other site 1191061003145 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1191061003146 homodimer interaction site [polypeptide binding]; other site 1191061003147 cofactor binding site; other site 1191061003148 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 1191061003149 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 1191061003150 lipoprotein, YaeC family; Region: TIGR00363 1191061003151 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061003152 dimer interface [polypeptide binding]; other site 1191061003153 conserved gate region; other site 1191061003154 ABC-ATPase subunit interface; other site 1191061003155 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1191061003156 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1191061003157 Walker A/P-loop; other site 1191061003158 ATP binding site [chemical binding]; other site 1191061003159 Q-loop/lid; other site 1191061003160 ABC transporter signature motif; other site 1191061003161 Walker B; other site 1191061003162 D-loop; other site 1191061003163 H-loop/switch region; other site 1191061003164 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1191061003165 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 1191061003166 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1191061003167 active site 1191061003168 motif I; other site 1191061003169 motif II; other site 1191061003170 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1191061003171 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1191061003172 active site 1191061003173 catalytic tetrad [active] 1191061003174 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061003175 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061003176 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1191061003177 dimerization interface [polypeptide binding]; other site 1191061003178 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1191061003179 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061003180 putative substrate translocation pore; other site 1191061003181 hypothetical protein; Provisional; Region: PRK05421 1191061003182 putative catalytic site [active] 1191061003183 putative metal binding site [ion binding]; other site 1191061003184 putative phosphate binding site [ion binding]; other site 1191061003185 putative catalytic site [active] 1191061003186 putative phosphate binding site [ion binding]; other site 1191061003187 putative metal binding site [ion binding]; other site 1191061003188 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1191061003189 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191061003190 S-adenosylmethionine binding site [chemical binding]; other site 1191061003191 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1191061003192 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1191061003193 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1191061003194 catalytic residue [active] 1191061003195 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1191061003196 ATP binding site [chemical binding]; other site 1191061003197 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1191061003198 substrate binding site [chemical binding]; other site 1191061003199 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1191061003200 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1191061003201 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1191061003202 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 1191061003203 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191061003204 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 1191061003205 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1191061003206 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1191061003207 active site 1191061003208 catalytic site [active] 1191061003209 substrate binding site [chemical binding]; other site 1191061003210 C-N hydrolase family amidase; Provisional; Region: PRK10438 1191061003211 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 1191061003212 putative active site [active] 1191061003213 catalytic triad [active] 1191061003214 dimer interface [polypeptide binding]; other site 1191061003215 multimer interface [polypeptide binding]; other site 1191061003216 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 1191061003217 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1191061003218 active site 1191061003219 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 1191061003220 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1191061003221 dimer interface [polypeptide binding]; other site 1191061003222 active site 1191061003223 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1191061003224 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1191061003225 putative active site [active] 1191061003226 putative dimer interface [polypeptide binding]; other site 1191061003227 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 1191061003228 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 1191061003229 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1191061003230 E3 interaction surface; other site 1191061003231 lipoyl attachment site [posttranslational modification]; other site 1191061003232 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 1191061003233 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 1191061003234 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 1191061003235 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 1191061003236 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 1191061003237 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 1191061003238 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 1191061003239 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1191061003240 catalytic loop [active] 1191061003241 iron binding site [ion binding]; other site 1191061003242 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 1191061003243 FAD binding pocket [chemical binding]; other site 1191061003244 FAD binding motif [chemical binding]; other site 1191061003245 phosphate binding motif [ion binding]; other site 1191061003246 beta-alpha-beta structure motif; other site 1191061003247 NAD binding pocket [chemical binding]; other site 1191061003248 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2991 1191061003249 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1191061003250 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1191061003251 active site 1191061003252 catalytic site [active] 1191061003253 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1191061003254 active site 1191061003255 DNA polymerase IV; Validated; Region: PRK02406 1191061003256 DNA binding site [nucleotide binding] 1191061003257 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1191061003258 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1191061003259 Coenzyme A binding pocket [chemical binding]; other site 1191061003260 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 1191061003261 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 1191061003262 metal binding site [ion binding]; metal-binding site 1191061003263 dimer interface [polypeptide binding]; other site 1191061003264 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1191061003265 active site 1191061003266 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 1191061003267 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 1191061003268 putative acyl transferase; Provisional; Region: PRK10191 1191061003269 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1191061003270 trimer interface [polypeptide binding]; other site 1191061003271 active site 1191061003272 substrate binding site [chemical binding]; other site 1191061003273 CoA binding site [chemical binding]; other site 1191061003274 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1191061003275 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1191061003276 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1191061003277 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1191061003278 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1191061003279 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1191061003280 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1191061003281 active site 1191061003282 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 1191061003283 Chain length determinant protein; Region: Wzz; pfam02706 1191061003284 chain length determinant protein EpsF; Region: EpsF; TIGR03017 1191061003285 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1191061003286 AAA domain; Region: AAA_31; pfam13614 1191061003287 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 1191061003288 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1191061003289 SLBB domain; Region: SLBB; pfam10531 1191061003290 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 1191061003291 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 1191061003292 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1191061003293 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 1191061003294 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1191061003295 tetramerization interface [polypeptide binding]; other site 1191061003296 NAD(P) binding site [chemical binding]; other site 1191061003297 catalytic residues [active] 1191061003298 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 1191061003299 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1191061003300 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1191061003301 N-terminal plug; other site 1191061003302 ligand-binding site [chemical binding]; other site 1191061003303 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1191061003304 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 1191061003305 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1191061003306 DNA-binding site [nucleotide binding]; DNA binding site 1191061003307 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1191061003308 D-mannonate oxidoreductase; Provisional; Region: PRK15037 1191061003309 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1191061003310 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1191061003311 mannonate dehydratase; Region: uxuA; TIGR00695 1191061003312 mannonate dehydratase; Provisional; Region: PRK03906 1191061003313 hypothetical protein; Provisional; Region: PRK13687 1191061003314 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1191061003315 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1191061003316 Coenzyme A binding pocket [chemical binding]; other site 1191061003317 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1191061003318 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191061003319 S-adenosylmethionine binding site [chemical binding]; other site 1191061003320 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1191061003321 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191061003322 S-adenosylmethionine binding site [chemical binding]; other site 1191061003323 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1191061003324 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1191061003325 EamA-like transporter family; Region: EamA; pfam00892 1191061003326 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1191061003327 EamA-like transporter family; Region: EamA; pfam00892 1191061003328 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1191061003329 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061003330 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1191061003331 dimerization interface [polypeptide binding]; other site 1191061003332 substrate binding pocket [chemical binding]; other site 1191061003333 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 1191061003334 benzoate transport; Region: 2A0115; TIGR00895 1191061003335 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061003336 putative substrate translocation pore; other site 1191061003337 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061003338 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1191061003339 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1191061003340 DNA binding site [nucleotide binding] 1191061003341 domain linker motif; other site 1191061003342 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1191061003343 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1191061003344 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1191061003345 inhibitor site; inhibition site 1191061003346 active site 1191061003347 dimer interface [polypeptide binding]; other site 1191061003348 catalytic residue [active] 1191061003349 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1191061003350 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1191061003351 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 1191061003352 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 1191061003353 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 1191061003354 active site 1191061003355 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 1191061003356 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1191061003357 DNA-binding site [nucleotide binding]; DNA binding site 1191061003358 UTRA domain; Region: UTRA; pfam07702 1191061003359 HutD; Region: HutD; pfam05962 1191061003360 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1191061003361 active sites [active] 1191061003362 tetramer interface [polypeptide binding]; other site 1191061003363 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1191061003364 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061003365 ABC-ATPase subunit interface; other site 1191061003366 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061003367 dimer interface [polypeptide binding]; other site 1191061003368 conserved gate region; other site 1191061003369 ABC-ATPase subunit interface; other site 1191061003370 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1191061003371 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1191061003372 Walker A/P-loop; other site 1191061003373 ATP binding site [chemical binding]; other site 1191061003374 Q-loop/lid; other site 1191061003375 ABC transporter signature motif; other site 1191061003376 Walker B; other site 1191061003377 D-loop; other site 1191061003378 H-loop/switch region; other site 1191061003379 urocanate hydratase; Provisional; Region: PRK05414 1191061003380 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 1191061003381 imidazolonepropionase; Validated; Region: PRK09356 1191061003382 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1191061003383 active site 1191061003384 N-formylglutamate amidohydrolase; Region: FGase; cl01522 1191061003385 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1191061003386 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1191061003387 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 1191061003388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 1191061003389 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 1191061003390 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1191061003391 D5 N terminal like; Region: D5_N; smart00885 1191061003392 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 1191061003393 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 1191061003394 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 1191061003395 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 1191061003396 Phage polarity suppression protein (Psu); Region: Psu; pfam07455 1191061003397 integrase; Provisional; Region: PRK09692 1191061003398 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1191061003399 active site 1191061003400 Int/Topo IB signature motif; other site 1191061003401 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1191061003402 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1191061003403 putative catalytic cysteine [active] 1191061003404 gamma-glutamyl kinase; Provisional; Region: PRK05429 1191061003405 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1191061003406 nucleotide binding site [chemical binding]; other site 1191061003407 homotetrameric interface [polypeptide binding]; other site 1191061003408 putative phosphate binding site [ion binding]; other site 1191061003409 putative allosteric binding site; other site 1191061003410 PUA domain; Region: PUA; pfam01472 1191061003411 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1191061003412 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1191061003413 trimer interface [polypeptide binding]; other site 1191061003414 eyelet of channel; other site 1191061003415 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 1191061003416 NlpC/P60 family; Region: NLPC_P60; pfam00877 1191061003417 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061003418 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061003419 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1191061003420 dimerization interface [polypeptide binding]; other site 1191061003421 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1191061003422 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1191061003423 membrane-bound complex binding site; other site 1191061003424 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061003425 dimer interface [polypeptide binding]; other site 1191061003426 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 1191061003427 conserved gate region; other site 1191061003428 putative PBP binding loops; other site 1191061003429 ABC-ATPase subunit interface; other site 1191061003430 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061003431 dimer interface [polypeptide binding]; other site 1191061003432 conserved gate region; other site 1191061003433 putative PBP binding loops; other site 1191061003434 ABC-ATPase subunit interface; other site 1191061003435 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1191061003436 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1191061003437 Walker A/P-loop; other site 1191061003438 ATP binding site [chemical binding]; other site 1191061003439 Q-loop/lid; other site 1191061003440 ABC transporter signature motif; other site 1191061003441 Walker B; other site 1191061003442 D-loop; other site 1191061003443 H-loop/switch region; other site 1191061003444 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 1191061003445 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1191061003446 catalytic residues [active] 1191061003447 Cupin domain; Region: Cupin_2; pfam07883 1191061003448 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1191061003449 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061003450 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1191061003451 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1191061003452 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1191061003453 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1191061003454 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061003455 dimer interface [polypeptide binding]; other site 1191061003456 conserved gate region; other site 1191061003457 putative PBP binding loops; other site 1191061003458 ABC-ATPase subunit interface; other site 1191061003459 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1191061003460 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061003461 dimer interface [polypeptide binding]; other site 1191061003462 conserved gate region; other site 1191061003463 putative PBP binding loops; other site 1191061003464 ABC-ATPase subunit interface; other site 1191061003465 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 1191061003466 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1191061003467 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1191061003468 Walker A/P-loop; other site 1191061003469 ATP binding site [chemical binding]; other site 1191061003470 Q-loop/lid; other site 1191061003471 ABC transporter signature motif; other site 1191061003472 Walker B; other site 1191061003473 D-loop; other site 1191061003474 H-loop/switch region; other site 1191061003475 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 1191061003476 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1191061003477 DNA binding residues [nucleotide binding] 1191061003478 putative fimbrial protein TcfA; Provisional; Region: PRK15308 1191061003479 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1191061003480 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1191061003481 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061003482 dimer interface [polypeptide binding]; other site 1191061003483 conserved gate region; other site 1191061003484 putative PBP binding loops; other site 1191061003485 ABC-ATPase subunit interface; other site 1191061003486 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1191061003487 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061003488 dimer interface [polypeptide binding]; other site 1191061003489 conserved gate region; other site 1191061003490 putative PBP binding loops; other site 1191061003491 ABC-ATPase subunit interface; other site 1191061003492 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1191061003493 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1191061003494 Walker A/P-loop; other site 1191061003495 ATP binding site [chemical binding]; other site 1191061003496 Q-loop/lid; other site 1191061003497 ABC transporter signature motif; other site 1191061003498 Walker B; other site 1191061003499 D-loop; other site 1191061003500 H-loop/switch region; other site 1191061003501 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1191061003502 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1191061003503 substrate binding pocket [chemical binding]; other site 1191061003504 membrane-bound complex binding site; other site 1191061003505 hinge residues; other site 1191061003506 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1191061003507 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1191061003508 Walker A/P-loop; other site 1191061003509 ATP binding site [chemical binding]; other site 1191061003510 Q-loop/lid; other site 1191061003511 ABC transporter signature motif; other site 1191061003512 Walker B; other site 1191061003513 D-loop; other site 1191061003514 H-loop/switch region; other site 1191061003515 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1191061003516 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1191061003517 Walker A/P-loop; other site 1191061003518 ATP binding site [chemical binding]; other site 1191061003519 Q-loop/lid; other site 1191061003520 ABC transporter signature motif; other site 1191061003521 Walker B; other site 1191061003522 D-loop; other site 1191061003523 H-loop/switch region; other site 1191061003524 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1191061003525 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1191061003526 TM-ABC transporter signature motif; other site 1191061003527 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1191061003528 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1191061003529 TM-ABC transporter signature motif; other site 1191061003530 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1191061003531 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 1191061003532 putative ligand binding site [chemical binding]; other site 1191061003533 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 1191061003534 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 1191061003535 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 1191061003536 ethanolamine permease; Region: 2A0305; TIGR00908 1191061003537 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 1191061003538 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 1191061003539 S-methylmethionine transporter; Provisional; Region: PRK11387 1191061003540 S-methylmethionine transporter; Provisional; Region: PRK11387 1191061003541 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1191061003542 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1191061003543 ferric transporter ATP-binding subunit; Provisional; Region: fbpC; PRK11432 1191061003544 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1191061003545 Walker A/P-loop; other site 1191061003546 ATP binding site [chemical binding]; other site 1191061003547 Q-loop/lid; other site 1191061003548 ABC transporter signature motif; other site 1191061003549 Walker B; other site 1191061003550 D-loop; other site 1191061003551 H-loop/switch region; other site 1191061003552 TOBE domain; Region: TOBE_2; pfam08402 1191061003553 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1191061003554 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061003555 dimer interface [polypeptide binding]; other site 1191061003556 conserved gate region; other site 1191061003557 putative PBP binding loops; other site 1191061003558 ABC-ATPase subunit interface; other site 1191061003559 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061003560 dimer interface [polypeptide binding]; other site 1191061003561 conserved gate region; other site 1191061003562 putative PBP binding loops; other site 1191061003563 ABC-ATPase subunit interface; other site 1191061003564 Chemotaxis-inhibiting protein CHIPS; Region: CHIPS; cl10100 1191061003565 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1191061003566 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1191061003567 regulatory protein UhpC; Provisional; Region: PRK11663 1191061003568 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061003569 putative substrate translocation pore; other site 1191061003570 Signal transduction histidine kinase, glucose-6-phosphate specific [Signal transduction mechanisms]; Region: UhpB; COG3851 1191061003571 MASE1; Region: MASE1; pfam05231 1191061003572 Histidine kinase; Region: HisKA_3; pfam07730 1191061003573 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191061003574 ATP binding site [chemical binding]; other site 1191061003575 Mg2+ binding site [ion binding]; other site 1191061003576 G-X-G motif; other site 1191061003577 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1191061003578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191061003579 active site 1191061003580 phosphorylation site [posttranslational modification] 1191061003581 intermolecular recognition site; other site 1191061003582 dimerization interface [polypeptide binding]; other site 1191061003583 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1191061003584 DNA binding residues [nucleotide binding] 1191061003585 dimerization interface [polypeptide binding]; other site 1191061003586 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 1191061003587 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1191061003588 substrate binding pocket [chemical binding]; other site 1191061003589 membrane-bound complex binding site; other site 1191061003590 hinge residues; other site 1191061003591 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 1191061003592 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1191061003593 Walker A/P-loop; other site 1191061003594 ATP binding site [chemical binding]; other site 1191061003595 Q-loop/lid; other site 1191061003596 ABC transporter signature motif; other site 1191061003597 Walker B; other site 1191061003598 D-loop; other site 1191061003599 H-loop/switch region; other site 1191061003600 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1191061003601 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061003602 dimer interface [polypeptide binding]; other site 1191061003603 conserved gate region; other site 1191061003604 putative PBP binding loops; other site 1191061003605 ABC-ATPase subunit interface; other site 1191061003606 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1191061003607 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 1191061003608 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1191061003609 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1191061003610 putative acyl-acceptor binding pocket; other site 1191061003611 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 1191061003612 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 1191061003613 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1191061003614 dimer interface [polypeptide binding]; other site 1191061003615 active site 1191061003616 Schiff base residues; other site 1191061003617 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 1191061003618 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1191061003619 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1191061003620 Isochorismatase family; Region: Isochorismatase; pfam00857 1191061003621 catalytic triad [active] 1191061003622 conserved cis-peptide bond; other site 1191061003623 microcin B17 transporter; Reviewed; Region: PRK11098 1191061003624 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 1191061003625 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 1191061003626 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 1191061003627 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1191061003628 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1191061003629 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1191061003630 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 1191061003631 drug efflux system protein MdtG; Provisional; Region: PRK09874 1191061003632 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061003633 putative substrate translocation pore; other site 1191061003634 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 1191061003635 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1191061003636 NADP binding site [chemical binding]; other site 1191061003637 homodimer interface [polypeptide binding]; other site 1191061003638 active site 1191061003639 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061003640 D-galactonate transporter; Region: 2A0114; TIGR00893 1191061003641 putative substrate translocation pore; other site 1191061003642 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 1191061003643 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1191061003644 DNA binding site [nucleotide binding] 1191061003645 domain linker motif; other site 1191061003646 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1191061003647 putative dimerization interface [polypeptide binding]; other site 1191061003648 putative ligand binding site [chemical binding]; other site 1191061003649 anti-RssB factor; Provisional; Region: PRK10244 1191061003650 alkaline phosphatase; Provisional; Region: PRK10518 1191061003651 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1191061003652 active site 1191061003653 dimer interface [polypeptide binding]; other site 1191061003654 psiF repeat; Region: PsiF_repeat; pfam07769 1191061003655 psiF repeat; Region: PsiF_repeat; pfam07769 1191061003656 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1191061003657 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1191061003658 hypothetical protein; Validated; Region: PRK00124 1191061003659 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 1191061003660 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 1191061003661 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1191061003662 ADP binding site [chemical binding]; other site 1191061003663 magnesium binding site [ion binding]; other site 1191061003664 putative shikimate binding site; other site 1191061003665 hypothetical protein; Provisional; Region: PRK10380 1191061003666 hypothetical protein; Provisional; Region: PRK10481 1191061003667 hypothetical protein; Provisional; Region: PRK10579 1191061003668 recombination associated protein; Reviewed; Region: rdgC; PRK00321 1191061003669 fructokinase; Reviewed; Region: PRK09557 1191061003670 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1191061003671 nucleotide binding site [chemical binding]; other site 1191061003672 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 1191061003673 exonuclease subunit SbcC; Provisional; Region: PRK10246 1191061003674 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1191061003675 Walker A/P-loop; other site 1191061003676 ATP binding site [chemical binding]; other site 1191061003677 Q-loop/lid; other site 1191061003678 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1191061003679 ABC transporter signature motif; other site 1191061003680 Walker B; other site 1191061003681 D-loop; other site 1191061003682 H-loop/switch region; other site 1191061003683 exonuclease subunit SbcD; Provisional; Region: PRK10966 1191061003684 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1191061003685 active site 1191061003686 metal binding site [ion binding]; metal-binding site 1191061003687 DNA binding site [nucleotide binding] 1191061003688 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1191061003689 transcriptional regulator PhoB; Provisional; Region: PRK10161 1191061003690 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191061003691 active site 1191061003692 phosphorylation site [posttranslational modification] 1191061003693 intermolecular recognition site; other site 1191061003694 dimerization interface [polypeptide binding]; other site 1191061003695 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1191061003696 DNA binding site [nucleotide binding] 1191061003697 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 1191061003698 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 1191061003699 PAS domain; Region: PAS; smart00091 1191061003700 putative active site [active] 1191061003701 heme pocket [chemical binding]; other site 1191061003702 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191061003703 dimer interface [polypeptide binding]; other site 1191061003704 phosphorylation site [posttranslational modification] 1191061003705 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191061003706 ATP binding site [chemical binding]; other site 1191061003707 Mg2+ binding site [ion binding]; other site 1191061003708 G-X-G motif; other site 1191061003709 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 1191061003710 putative proline-specific permease; Provisional; Region: proY; PRK10580 1191061003711 Spore germination protein; Region: Spore_permease; cl17796 1191061003712 maltodextrin glucosidase; Provisional; Region: PRK10785 1191061003713 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1191061003714 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1191061003715 active site 1191061003716 homodimer interface [polypeptide binding]; other site 1191061003717 catalytic site [active] 1191061003718 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061003719 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061003720 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1191061003721 dimerization interface [polypeptide binding]; other site 1191061003722 Isochorismatase family; Region: Isochorismatase; pfam00857 1191061003723 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1191061003724 catalytic triad [active] 1191061003725 dimer interface [polypeptide binding]; other site 1191061003726 conserved cis-peptide bond; other site 1191061003727 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 1191061003728 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1191061003729 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1191061003730 active site 1191061003731 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 1191061003732 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 1191061003733 peroxidase; Provisional; Region: PRK15000 1191061003734 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1191061003735 dimer interface [polypeptide binding]; other site 1191061003736 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1191061003737 catalytic triad [active] 1191061003738 peroxidatic and resolving cysteines [active] 1191061003739 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 1191061003740 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1191061003741 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1191061003742 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1191061003743 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 1191061003744 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1191061003745 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 1191061003746 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1191061003747 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1191061003748 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1191061003749 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1191061003750 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1191061003751 Protein export membrane protein; Region: SecD_SecF; pfam02355 1191061003752 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1191061003753 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1191061003754 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1191061003755 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1191061003756 active site 1191061003757 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1191061003758 Predicted transcriptional regulator [Transcription]; Region: COG2378 1191061003759 HTH domain; Region: HTH_11; pfam08279 1191061003760 WYL domain; Region: WYL; pfam13280 1191061003761 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 1191061003762 hypothetical protein; Provisional; Region: PRK11530 1191061003763 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1191061003764 ATP cone domain; Region: ATP-cone; pfam03477 1191061003765 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 1191061003766 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1191061003767 catalytic motif [active] 1191061003768 Zn binding site [ion binding]; other site 1191061003769 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 1191061003770 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1191061003771 homopentamer interface [polypeptide binding]; other site 1191061003772 active site 1191061003773 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1191061003774 putative RNA binding site [nucleotide binding]; other site 1191061003775 thiamine monophosphate kinase; Provisional; Region: PRK05731 1191061003776 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1191061003777 ATP binding site [chemical binding]; other site 1191061003778 dimerization interface [polypeptide binding]; other site 1191061003779 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1191061003780 tetramer interfaces [polypeptide binding]; other site 1191061003781 binuclear metal-binding site [ion binding]; other site 1191061003782 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1191061003783 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1191061003784 active site 1191061003785 catalytic tetrad [active] 1191061003786 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1191061003787 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1191061003788 TPP-binding site; other site 1191061003789 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1191061003790 PYR/PP interface [polypeptide binding]; other site 1191061003791 dimer interface [polypeptide binding]; other site 1191061003792 TPP binding site [chemical binding]; other site 1191061003793 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1191061003794 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1191061003795 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1191061003796 substrate binding pocket [chemical binding]; other site 1191061003797 chain length determination region; other site 1191061003798 substrate-Mg2+ binding site; other site 1191061003799 catalytic residues [active] 1191061003800 aspartate-rich region 1; other site 1191061003801 active site lid residues [active] 1191061003802 aspartate-rich region 2; other site 1191061003803 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1191061003804 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 1191061003805 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1191061003806 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1191061003807 Ligand Binding Site [chemical binding]; other site 1191061003808 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1191061003809 active site residue [active] 1191061003810 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 1191061003811 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1191061003812 conserved cys residue [active] 1191061003813 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1191061003814 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1191061003815 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1191061003816 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1191061003817 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1191061003818 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061003819 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1191061003820 putative substrate translocation pore; other site 1191061003821 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1191061003822 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1191061003823 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1191061003824 MFS/sugar transport protein; Region: MFS_2; pfam13347 1191061003825 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061003826 putative substrate translocation pore; other site 1191061003827 putative FAD-binding dehydrogenase; Reviewed; Region: PRK06134 1191061003828 Predicted oxidoreductase [General function prediction only]; Region: COG3573 1191061003829 NIPSNAP; Region: NIPSNAP; pfam07978 1191061003830 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12843 1191061003831 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1191061003832 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 1191061003833 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1191061003834 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1191061003835 shikimate binding site; other site 1191061003836 NAD(P) binding site [chemical binding]; other site 1191061003837 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 1191061003838 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1191061003839 Bacterial transcriptional regulator; Region: IclR; pfam01614 1191061003840 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 1191061003841 UbiA prenyltransferase family; Region: UbiA; pfam01040 1191061003842 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 1191061003843 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1191061003844 Subunit I/III interface [polypeptide binding]; other site 1191061003845 Subunit III/IV interface [polypeptide binding]; other site 1191061003846 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1191061003847 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1191061003848 D-pathway; other site 1191061003849 Putative ubiquinol binding site [chemical binding]; other site 1191061003850 Low-spin heme (heme b) binding site [chemical binding]; other site 1191061003851 Putative water exit pathway; other site 1191061003852 Binuclear center (heme o3/CuB) [ion binding]; other site 1191061003853 K-pathway; other site 1191061003854 Putative proton exit pathway; other site 1191061003855 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 1191061003856 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1191061003857 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1191061003858 muropeptide transporter; Reviewed; Region: ampG; PRK11902 1191061003859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061003860 putative substrate translocation pore; other site 1191061003861 hypothetical protein; Provisional; Region: PRK11627 1191061003862 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 1191061003863 transcriptional regulator BolA; Provisional; Region: PRK11628 1191061003864 trigger factor; Provisional; Region: tig; PRK01490 1191061003865 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1191061003866 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1191061003867 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1191061003868 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1191061003869 oligomer interface [polypeptide binding]; other site 1191061003870 active site residues [active] 1191061003871 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1191061003872 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1191061003873 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191061003874 Walker A motif; other site 1191061003875 ATP binding site [chemical binding]; other site 1191061003876 Walker B motif; other site 1191061003877 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1191061003878 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 1191061003879 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1191061003880 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1191061003881 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191061003882 Walker A motif; other site 1191061003883 ATP binding site [chemical binding]; other site 1191061003884 Walker B motif; other site 1191061003885 arginine finger; other site 1191061003886 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1191061003887 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1191061003888 IHF dimer interface [polypeptide binding]; other site 1191061003889 IHF - DNA interface [nucleotide binding]; other site 1191061003890 periplasmic folding chaperone; Provisional; Region: PRK10788 1191061003891 SurA N-terminal domain; Region: SurA_N_3; cl07813 1191061003892 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1191061003893 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 1191061003894 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1191061003895 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1191061003896 active site 1191061003897 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1191061003898 Ligand Binding Site [chemical binding]; other site 1191061003899 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1191061003900 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1191061003901 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1191061003902 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 1191061003903 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1191061003904 active site 1191061003905 motif I; other site 1191061003906 motif II; other site 1191061003907 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1191061003908 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1191061003909 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1191061003910 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1191061003911 catalytic residue [active] 1191061003912 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1191061003913 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1191061003914 putative DNA binding site [nucleotide binding]; other site 1191061003915 putative Zn2+ binding site [ion binding]; other site 1191061003916 AsnC family; Region: AsnC_trans_reg; pfam01037 1191061003917 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1191061003918 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1191061003919 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1191061003920 Walker A/P-loop; other site 1191061003921 ATP binding site [chemical binding]; other site 1191061003922 Q-loop/lid; other site 1191061003923 ABC transporter signature motif; other site 1191061003924 Walker B; other site 1191061003925 D-loop; other site 1191061003926 H-loop/switch region; other site 1191061003927 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 1191061003928 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1191061003929 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1191061003930 Walker A/P-loop; other site 1191061003931 ATP binding site [chemical binding]; other site 1191061003932 Q-loop/lid; other site 1191061003933 ABC transporter signature motif; other site 1191061003934 Walker B; other site 1191061003935 D-loop; other site 1191061003936 H-loop/switch region; other site 1191061003937 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 1191061003938 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1191061003939 ammonium transporter; Provisional; Region: PRK10666 1191061003940 acyl-CoA thioesterase II; Provisional; Region: PRK10526 1191061003941 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1191061003942 active site 1191061003943 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1191061003944 catalytic triad [active] 1191061003945 dimer interface [polypeptide binding]; other site 1191061003946 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 1191061003947 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1191061003948 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1191061003949 DNA binding site [nucleotide binding] 1191061003950 active site 1191061003951 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1191061003952 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1191061003953 DNA-binding site [nucleotide binding]; DNA binding site 1191061003954 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1191061003955 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061003956 homodimer interface [polypeptide binding]; other site 1191061003957 catalytic residue [active] 1191061003958 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1191061003959 Predicted membrane protein [Function unknown]; Region: COG2364 1191061003960 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1191061003961 Protein of unknown function (DUF1428); Region: DUF1428; cl02319 1191061003962 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 1191061003963 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 1191061003964 putative metal binding site [ion binding]; other site 1191061003965 putative homodimer interface [polypeptide binding]; other site 1191061003966 putative homotetramer interface [polypeptide binding]; other site 1191061003967 putative homodimer-homodimer interface [polypeptide binding]; other site 1191061003968 putative allosteric switch controlling residues; other site 1191061003969 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1191061003970 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1191061003971 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1191061003972 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1191061003973 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1191061003974 Walker A/P-loop; other site 1191061003975 ATP binding site [chemical binding]; other site 1191061003976 Q-loop/lid; other site 1191061003977 ABC transporter signature motif; other site 1191061003978 Walker B; other site 1191061003979 D-loop; other site 1191061003980 H-loop/switch region; other site 1191061003981 TOBE domain; Region: TOBE_2; pfam08402 1191061003982 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1191061003983 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1191061003984 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061003985 dimer interface [polypeptide binding]; other site 1191061003986 conserved gate region; other site 1191061003987 ABC-ATPase subunit interface; other site 1191061003988 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1191061003989 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061003990 dimer interface [polypeptide binding]; other site 1191061003991 conserved gate region; other site 1191061003992 putative PBP binding loops; other site 1191061003993 ABC-ATPase subunit interface; other site 1191061003994 Arabinogalactan endo-1,4-beta-galactosidase [Carbohydrate transport and metabolism]; Region: COG3867 1191061003995 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1191061003996 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1191061003997 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1191061003998 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 1191061003999 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1191061004000 active site turn [active] 1191061004001 phosphorylation site [posttranslational modification] 1191061004002 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1191061004003 trimer interface; other site 1191061004004 sugar binding site [chemical binding]; other site 1191061004005 lac repressor; Reviewed; Region: lacI; PRK09526 1191061004006 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1191061004007 DNA binding site [nucleotide binding] 1191061004008 domain linker motif; other site 1191061004009 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1191061004010 ligand binding site [chemical binding]; other site 1191061004011 dimerization interface (open form) [polypeptide binding]; other site 1191061004012 dimerization interface (closed form) [polypeptide binding]; other site 1191061004013 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1191061004014 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1191061004015 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1191061004016 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1191061004017 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1191061004018 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1191061004019 DNA-binding site [nucleotide binding]; DNA binding site 1191061004020 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1191061004021 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061004022 homodimer interface [polypeptide binding]; other site 1191061004023 catalytic residue [active] 1191061004024 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 1191061004025 maltose O-acetyltransferase; Provisional; Region: PRK10092 1191061004026 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1191061004027 active site 1191061004028 substrate binding site [chemical binding]; other site 1191061004029 trimer interface [polypeptide binding]; other site 1191061004030 CoA binding site [chemical binding]; other site 1191061004031 gene expression modulator; Provisional; Region: PRK10945 1191061004032 Hha toxicity attenuator; Provisional; Region: PRK10667 1191061004033 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 1191061004034 Protein export membrane protein; Region: SecD_SecF; cl14618 1191061004035 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1191061004036 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1191061004037 HlyD family secretion protein; Region: HlyD_3; pfam13437 1191061004038 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 1191061004039 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1191061004040 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1191061004041 hypothetical protein; Provisional; Region: PRK11281 1191061004042 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1191061004043 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1191061004044 putative transposase; Provisional; Region: PRK09857 1191061004045 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1191061004046 hypothetical protein; Provisional; Region: PRK11038 1191061004047 primosomal replication protein N''; Provisional; Region: PRK10093 1191061004048 hypothetical protein; Provisional; Region: PRK10527 1191061004049 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1191061004050 active site 1191061004051 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191061004052 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 1191061004053 Walker A motif; other site 1191061004054 ATP binding site [chemical binding]; other site 1191061004055 Walker B motif; other site 1191061004056 arginine finger; other site 1191061004057 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1191061004058 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 1191061004059 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 1191061004060 hypothetical protein; Validated; Region: PRK00153 1191061004061 recombination protein RecR; Reviewed; Region: recR; PRK00076 1191061004062 RecR protein; Region: RecR; pfam02132 1191061004063 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1191061004064 putative active site [active] 1191061004065 putative metal-binding site [ion binding]; other site 1191061004066 tetramer interface [polypeptide binding]; other site 1191061004067 heat shock protein 90; Provisional; Region: PRK05218 1191061004068 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191061004069 ATP binding site [chemical binding]; other site 1191061004070 Mg2+ binding site [ion binding]; other site 1191061004071 G-X-G motif; other site 1191061004072 adenylate kinase; Reviewed; Region: adk; PRK00279 1191061004073 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1191061004074 AMP-binding site [chemical binding]; other site 1191061004075 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1191061004076 ferrochelatase; Reviewed; Region: hemH; PRK00035 1191061004077 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1191061004078 C-terminal domain interface [polypeptide binding]; other site 1191061004079 active site 1191061004080 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1191061004081 active site 1191061004082 N-terminal domain interface [polypeptide binding]; other site 1191061004083 inosine/guanosine kinase; Provisional; Region: PRK15074 1191061004084 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1191061004085 putative cation:proton antiport protein; Provisional; Region: PRK10669 1191061004086 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 1191061004087 TrkA-N domain; Region: TrkA_N; pfam02254 1191061004088 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061004089 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1191061004090 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061004091 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 1191061004092 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 1191061004093 active site 1191061004094 metal binding site [ion binding]; metal-binding site 1191061004095 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1191061004096 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1191061004097 putative deacylase active site [active] 1191061004098 TraB family; Region: TraB; cl12050 1191061004099 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1191061004100 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1191061004101 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1191061004102 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1191061004103 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1191061004104 N-terminal plug; other site 1191061004105 ligand-binding site [chemical binding]; other site 1191061004106 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1191061004107 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1191061004108 PLD-like domain; Region: PLDc_2; pfam13091 1191061004109 putative active site [active] 1191061004110 catalytic site [active] 1191061004111 Putative catalytic domain, repeat 2, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins; Region: PLDc_vPLD3_4_5_like_2; cd09107 1191061004112 PLD-like domain; Region: PLDc_2; pfam13091 1191061004113 putative active site [active] 1191061004114 putative catalytic site [active] 1191061004115 copper exporting ATPase; Provisional; Region: copA; PRK10671 1191061004116 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1191061004117 metal-binding site [ion binding] 1191061004118 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1191061004119 metal-binding site [ion binding] 1191061004120 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1191061004121 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1191061004122 motif II; other site 1191061004123 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 1191061004124 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1191061004125 DNA binding residues [nucleotide binding] 1191061004126 dimer interface [polypeptide binding]; other site 1191061004127 copper binding site [ion binding]; other site 1191061004128 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 1191061004129 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1191061004130 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1191061004131 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1191061004132 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 1191061004133 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1191061004134 Walker A/P-loop; other site 1191061004135 ATP binding site [chemical binding]; other site 1191061004136 Q-loop/lid; other site 1191061004137 ABC transporter signature motif; other site 1191061004138 Walker B; other site 1191061004139 D-loop; other site 1191061004140 H-loop/switch region; other site 1191061004141 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1191061004142 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1191061004143 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1191061004144 oxidoreductase; Provisional; Region: PRK08017 1191061004145 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1191061004146 NADP binding site [chemical binding]; other site 1191061004147 active site 1191061004148 steroid binding site; other site 1191061004149 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1191061004150 active site 1191061004151 catalytic triad [active] 1191061004152 oxyanion hole [active] 1191061004153 switch loop; other site 1191061004154 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 1191061004155 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1191061004156 Walker A/P-loop; other site 1191061004157 ATP binding site [chemical binding]; other site 1191061004158 Q-loop/lid; other site 1191061004159 ABC transporter signature motif; other site 1191061004160 Walker B; other site 1191061004161 D-loop; other site 1191061004162 H-loop/switch region; other site 1191061004163 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1191061004164 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1191061004165 putative monooxygenase; Provisional; Region: PRK11118 1191061004166 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1191061004167 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1191061004168 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 1191061004169 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 1191061004170 active site residue [active] 1191061004171 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1191061004172 ATP-grasp domain; Region: ATP-grasp; pfam02222 1191061004173 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1191061004174 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1191061004175 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1191061004176 putative active site [active] 1191061004177 putative metal binding site [ion binding]; other site 1191061004178 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1191061004179 substrate binding site [chemical binding]; other site 1191061004180 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1191061004181 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1191061004182 active site 1191061004183 HIGH motif; other site 1191061004184 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1191061004185 KMSKS motif; other site 1191061004186 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1191061004187 tRNA binding surface [nucleotide binding]; other site 1191061004188 anticodon binding site; other site 1191061004189 ribosome-associated protein; Provisional; Region: PRK11507 1191061004190 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 1191061004191 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1191061004192 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1191061004193 homodimer interface [polypeptide binding]; other site 1191061004194 NADP binding site [chemical binding]; other site 1191061004195 substrate binding site [chemical binding]; other site 1191061004196 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1191061004197 P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192 1191061004198 Int/Topo IB signature motif; other site 1191061004199 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869 1191061004200 FtsZ inhibitor protein; Reviewed; Region: kil; PRK11354 1191061004201 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1191061004202 Predicted transcriptional regulator [Transcription]; Region: COG2932 1191061004203 Catalytic site [active] 1191061004204 Replication protein P; Region: Phage_lambda_P; pfam06992 1191061004205 MarR family; Region: MarR_2; cl17246 1191061004206 NinB protein; Region: NinB; pfam05772 1191061004207 prophage protein NinE; Provisional; Region: PRK09689 1191061004208 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 1191061004209 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1191061004210 active site 1191061004211 metal binding site [ion binding]; metal-binding site 1191061004212 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 1191061004213 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 1191061004214 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 1191061004215 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 1191061004216 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cl10030 1191061004217 Phage terminase large subunit; Region: Terminase_3; cl12054 1191061004218 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 1191061004219 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 1191061004220 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1191061004221 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 1191061004222 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834 1191061004223 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 1191061004224 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 1191061004225 Protein of unknown function (DUF3277); Region: DUF3277; pfam11681 1191061004226 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 1191061004227 virion protein; Provisional; Region: V; PHA02564 1191061004228 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 1191061004229 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1191061004230 Baseplate J-like protein; Region: Baseplate_J; cl01294 1191061004231 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1191061004232 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1191061004233 integrase; Provisional; Region: PRK09692 1191061004234 active site 1191061004235 Int/Topo IB signature motif; other site 1191061004236 BRO family, N-terminal domain; Region: Bro-N; cl10591 1191061004237 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 1191061004238 Ash protein family; Region: Phage_ASH; pfam10554 1191061004239 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 1191061004240 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; cl17533 1191061004241 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 1191061004242 active site 1191061004243 metal binding site [ion binding]; metal-binding site 1191061004244 interdomain interaction site; other site 1191061004245 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 1191061004246 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1191061004247 ssDNA binding site [nucleotide binding]; other site 1191061004248 dimer interface [polypeptide binding]; other site 1191061004249 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1191061004250 Helix-turn-helix domain; Region: HTH_38; pfam13936 1191061004251 LabA_like proteins; Region: LabA_like; cd06167 1191061004252 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1191061004253 putative metal binding site [ion binding]; other site 1191061004254 conjugal transfer protein TrbH; Provisional; Region: PRK13883 1191061004255 Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120 1191061004256 Putative FMN-binding domain; Region: FMN_bind_2; cl17803 1191061004257 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1191061004258 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 1191061004259 Interdomain contacts; other site 1191061004260 Cytokine receptor motif; other site 1191061004261 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 1191061004262 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1191061004263 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1191061004264 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061004265 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1191061004266 dimerization interface [polypeptide binding]; other site 1191061004267 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1191061004268 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 1191061004269 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1191061004270 DNA binding site [nucleotide binding] 1191061004271 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 1191061004272 lysine decarboxylase CadA; Provisional; Region: PRK15400 1191061004273 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1191061004274 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1191061004275 homodimer interface [polypeptide binding]; other site 1191061004276 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061004277 catalytic residue [active] 1191061004278 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1191061004279 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1191061004280 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061004281 putative substrate translocation pore; other site 1191061004282 POT family; Region: PTR2; pfam00854 1191061004283 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 1191061004284 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1191061004285 dimer interface [polypeptide binding]; other site 1191061004286 putative anticodon binding site; other site 1191061004287 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1191061004288 motif 1; other site 1191061004289 active site 1191061004290 motif 2; other site 1191061004291 motif 3; other site 1191061004292 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1191061004293 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1191061004294 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1191061004295 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1191061004296 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1191061004297 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1191061004298 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1191061004299 DNA binding site [nucleotide binding] 1191061004300 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1191061004301 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1191061004302 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1191061004303 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 1191061004304 putative ligand binding site [chemical binding]; other site 1191061004305 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1191061004306 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1191061004307 Walker A/P-loop; other site 1191061004308 ATP binding site [chemical binding]; other site 1191061004309 Q-loop/lid; other site 1191061004310 ABC transporter signature motif; other site 1191061004311 Walker B; other site 1191061004312 D-loop; other site 1191061004313 H-loop/switch region; other site 1191061004314 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1191061004315 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1191061004316 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1191061004317 TM-ABC transporter signature motif; other site 1191061004318 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1191061004319 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1191061004320 active site turn [active] 1191061004321 phosphorylation site [posttranslational modification] 1191061004322 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1191061004323 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1191061004324 HPr interaction site; other site 1191061004325 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1191061004326 active site 1191061004327 phosphorylation site [posttranslational modification] 1191061004328 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1191061004329 beta-galactosidase; Region: BGL; TIGR03356 1191061004330 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1191061004331 CAT RNA binding domain; Region: CAT_RBD; smart01061 1191061004332 PRD domain; Region: PRD; pfam00874 1191061004333 PRD domain; Region: PRD; pfam00874 1191061004334 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 1191061004335 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1191061004336 DNA binding site [nucleotide binding] 1191061004337 domain linker motif; other site 1191061004338 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1191061004339 dimerization interface [polypeptide binding]; other site 1191061004340 ligand binding site [chemical binding]; other site 1191061004341 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1191061004342 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1191061004343 substrate binding [chemical binding]; other site 1191061004344 active site 1191061004345 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1191061004346 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1191061004347 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1191061004348 active site turn [active] 1191061004349 phosphorylation site [posttranslational modification] 1191061004350 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1191061004351 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 1191061004352 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1191061004353 trimer interface; other site 1191061004354 sugar binding site [chemical binding]; other site 1191061004355 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1191061004356 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1191061004357 putative substrate binding site [chemical binding]; other site 1191061004358 putative ATP binding site [chemical binding]; other site 1191061004359 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1191061004360 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1191061004361 Walker A/P-loop; other site 1191061004362 ATP binding site [chemical binding]; other site 1191061004363 Q-loop/lid; other site 1191061004364 ABC transporter signature motif; other site 1191061004365 Walker B; other site 1191061004366 D-loop; other site 1191061004367 H-loop/switch region; other site 1191061004368 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1191061004369 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1191061004370 ABC-ATPase subunit interface; other site 1191061004371 dimer interface [polypeptide binding]; other site 1191061004372 putative PBP binding regions; other site 1191061004373 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 1191061004374 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1191061004375 intersubunit interface [polypeptide binding]; other site 1191061004376 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 1191061004377 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1191061004378 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1191061004379 metal binding site [ion binding]; metal-binding site 1191061004380 putative dimer interface [polypeptide binding]; other site 1191061004381 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 1191061004382 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1191061004383 substrate binding pocket [chemical binding]; other site 1191061004384 membrane-bound complex binding site; other site 1191061004385 hinge residues; other site 1191061004386 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1191061004387 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1191061004388 active site 1191061004389 catalytic tetrad [active] 1191061004390 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1191061004391 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1191061004392 N-terminal plug; other site 1191061004393 ligand-binding site [chemical binding]; other site 1191061004394 phenylalanine transporter; Provisional; Region: PRK10249 1191061004395 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 1191061004396 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061004397 putative substrate translocation pore; other site 1191061004398 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1191061004399 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1191061004400 Metal-binding active site; metal-binding site 1191061004401 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1191061004402 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1191061004403 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1191061004404 short chain dehydrogenase; Provisional; Region: PRK06500 1191061004405 classical (c) SDRs; Region: SDR_c; cd05233 1191061004406 NAD(P) binding site [chemical binding]; other site 1191061004407 active site 1191061004408 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061004409 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061004410 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1191061004411 putative effector binding pocket; other site 1191061004412 putative dimerization interface [polypeptide binding]; other site 1191061004413 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 1191061004414 DNA binding residues [nucleotide binding] 1191061004415 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1191061004416 fimbrial outer membrane usher protein TcfC; Provisional; Region: PRK15310 1191061004417 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1191061004418 putative fimbrial protein TcfA; Provisional; Region: PRK15308 1191061004419 Vi polysaccharide biosynthesis protein TviA; Provisional; Region: PRK15183 1191061004420 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1191061004421 nudix motif; other site 1191061004422 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1191061004423 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1191061004424 DNA binding site [nucleotide binding] 1191061004425 domain linker motif; other site 1191061004426 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 1191061004427 dimerization interface [polypeptide binding]; other site 1191061004428 ligand binding site [chemical binding]; other site 1191061004429 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1191061004430 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1191061004431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061004432 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1191061004433 putative substrate translocation pore; other site 1191061004434 Helix-turn-helix domain; Region: HTH_31; pfam13560 1191061004435 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1191061004436 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191061004437 Walker A motif; other site 1191061004438 ATP binding site [chemical binding]; other site 1191061004439 Walker B motif; other site 1191061004440 arginine finger; other site 1191061004441 Transcriptional antiterminator [Transcription]; Region: COG3933 1191061004442 PRD domain; Region: PRD; pfam00874 1191061004443 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1191061004444 active pocket/dimerization site; other site 1191061004445 active site 1191061004446 phosphorylation site [posttranslational modification] 1191061004447 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 1191061004448 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1191061004449 active pocket/dimerization site; other site 1191061004450 active site 1191061004451 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1191061004452 active site 1191061004453 phosphorylation site [posttranslational modification] 1191061004454 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1191061004455 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 1191061004456 Glycosyl hydrolases family 32 N-terminal domain; Region: Glyco_hydro_32N; pfam00251 1191061004457 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1191061004458 substrate binding [chemical binding]; other site 1191061004459 active site 1191061004460 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1191061004461 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1191061004462 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1191061004463 type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713 1191061004464 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 1191061004465 type II secretion system protein D; Region: type_II_gspD; TIGR02517 1191061004466 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1191061004467 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1191061004468 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1191061004469 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1191061004470 type II secretion system protein E; Region: type_II_gspE; TIGR02533 1191061004471 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1191061004472 Walker A motif; other site 1191061004473 ATP binding site [chemical binding]; other site 1191061004474 Walker B motif; other site 1191061004475 type II secretion system protein F; Region: GspF; TIGR02120 1191061004476 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1191061004477 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1191061004478 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1191061004479 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1191061004480 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1191061004481 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1191061004482 type II secretion system protein I; Region: gspI; TIGR01707 1191061004483 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 1191061004484 type II secretion system protein J; Region: gspJ; TIGR01711 1191061004485 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 1191061004486 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 1191061004487 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 1191061004488 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 1191061004489 GspL periplasmic domain; Region: GspL_C; pfam12693 1191061004490 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 1191061004491 Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203 1191061004492 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1191061004493 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1191061004494 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1191061004495 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1191061004496 dimer interface [polypeptide binding]; other site 1191061004497 FMN binding site [chemical binding]; other site 1191061004498 hypothetical protein; Provisional; Region: PRK10250 1191061004499 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1191061004500 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1191061004501 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1191061004502 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1191061004503 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1191061004504 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061004505 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1191061004506 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1191061004507 N-terminal plug; other site 1191061004508 ligand-binding site [chemical binding]; other site 1191061004509 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 1191061004510 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 1191061004511 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1191061004512 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1191061004513 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1191061004514 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1191061004515 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1191061004516 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1191061004517 motif II; other site 1191061004518 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1191061004519 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1191061004520 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1191061004521 HlyD family secretion protein; Region: HlyD_3; pfam13437 1191061004522 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1191061004523 Predicted periplasmic protein [Function unknown]; Region: COG3698 1191061004524 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1191061004525 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 1191061004526 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1191061004527 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1191061004528 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_8; cd08495 1191061004529 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1191061004530 Protein of unknown function (DUF419); Region: DUF419; cl15265 1191061004531 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061004532 dimer interface [polypeptide binding]; other site 1191061004533 conserved gate region; other site 1191061004534 putative PBP binding loops; other site 1191061004535 ABC-ATPase subunit interface; other site 1191061004536 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1191061004537 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1191061004538 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1191061004539 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1191061004540 Walker A/P-loop; other site 1191061004541 ATP binding site [chemical binding]; other site 1191061004542 Q-loop/lid; other site 1191061004543 ABC transporter signature motif; other site 1191061004544 Walker B; other site 1191061004545 D-loop; other site 1191061004546 H-loop/switch region; other site 1191061004547 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1191061004548 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1191061004549 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1191061004550 Walker A/P-loop; other site 1191061004551 ATP binding site [chemical binding]; other site 1191061004552 Q-loop/lid; other site 1191061004553 ABC transporter signature motif; other site 1191061004554 Walker B; other site 1191061004555 D-loop; other site 1191061004556 H-loop/switch region; other site 1191061004557 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1191061004558 Amidase; Region: Amidase; cl11426 1191061004559 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1191061004560 allantoate amidohydrolase; Reviewed; Region: PRK12893 1191061004561 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1191061004562 active site 1191061004563 metal binding site [ion binding]; metal-binding site 1191061004564 dimer interface [polypeptide binding]; other site 1191061004565 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1191061004566 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1191061004567 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1191061004568 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1191061004569 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1191061004570 DNA-binding site [nucleotide binding]; DNA binding site 1191061004571 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1191061004572 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061004573 homodimer interface [polypeptide binding]; other site 1191061004574 catalytic residue [active] 1191061004575 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1191061004576 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1191061004577 substrate binding pocket [chemical binding]; other site 1191061004578 membrane-bound complex binding site; other site 1191061004579 hinge residues; other site 1191061004580 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1191061004581 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061004582 dimer interface [polypeptide binding]; other site 1191061004583 conserved gate region; other site 1191061004584 putative PBP binding loops; other site 1191061004585 ABC-ATPase subunit interface; other site 1191061004586 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1191061004587 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061004588 dimer interface [polypeptide binding]; other site 1191061004589 conserved gate region; other site 1191061004590 putative PBP binding loops; other site 1191061004591 ABC-ATPase subunit interface; other site 1191061004592 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1191061004593 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1191061004594 Walker A/P-loop; other site 1191061004595 ATP binding site [chemical binding]; other site 1191061004596 Q-loop/lid; other site 1191061004597 ABC transporter signature motif; other site 1191061004598 Walker B; other site 1191061004599 D-loop; other site 1191061004600 H-loop/switch region; other site 1191061004601 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1191061004602 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1191061004603 NAD(P) binding site [chemical binding]; other site 1191061004604 active site 1191061004605 hypothetical protein; Provisional; Region: PRK06062 1191061004606 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1191061004607 inhibitor-cofactor binding pocket; inhibition site 1191061004608 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061004609 catalytic residue [active] 1191061004610 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1191061004611 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1191061004612 Walker A/P-loop; other site 1191061004613 ATP binding site [chemical binding]; other site 1191061004614 Q-loop/lid; other site 1191061004615 ABC transporter signature motif; other site 1191061004616 Walker B; other site 1191061004617 D-loop; other site 1191061004618 H-loop/switch region; other site 1191061004619 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1191061004620 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1191061004621 Walker A/P-loop; other site 1191061004622 ATP binding site [chemical binding]; other site 1191061004623 Q-loop/lid; other site 1191061004624 ABC transporter signature motif; other site 1191061004625 Walker B; other site 1191061004626 D-loop; other site 1191061004627 H-loop/switch region; other site 1191061004628 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1191061004629 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061004630 dimer interface [polypeptide binding]; other site 1191061004631 conserved gate region; other site 1191061004632 ABC-ATPase subunit interface; other site 1191061004633 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1191061004634 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061004635 dimer interface [polypeptide binding]; other site 1191061004636 conserved gate region; other site 1191061004637 putative PBP binding loops; other site 1191061004638 ABC-ATPase subunit interface; other site 1191061004639 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1191061004640 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 1191061004641 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1191061004642 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1191061004643 choline dehydrogenase; Validated; Region: PRK02106 1191061004644 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1191061004645 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 1191061004646 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 1191061004647 tetrameric interface [polypeptide binding]; other site 1191061004648 NAD binding site [chemical binding]; other site 1191061004649 catalytic residues [active] 1191061004650 transcriptional regulator BetI; Validated; Region: PRK00767 1191061004651 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1191061004652 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1191061004653 choline transport protein BetT; Provisional; Region: PRK09928 1191061004654 Hok/gef family; Region: HOK_GEF; pfam01848 1191061004655 short chain dehydrogenase; Provisional; Region: PRK06114 1191061004656 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1191061004657 NAD(P) binding site [chemical binding]; other site 1191061004658 active site 1191061004659 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1191061004660 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 1191061004661 NAD binding site [chemical binding]; other site 1191061004662 homotetramer interface [polypeptide binding]; other site 1191061004663 homodimer interface [polypeptide binding]; other site 1191061004664 active site 1191061004665 substrate binding site [chemical binding]; other site 1191061004666 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1191061004667 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1191061004668 TM-ABC transporter signature motif; other site 1191061004669 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1191061004670 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1191061004671 Walker A/P-loop; other site 1191061004672 ATP binding site [chemical binding]; other site 1191061004673 Q-loop/lid; other site 1191061004674 ABC transporter signature motif; other site 1191061004675 Walker B; other site 1191061004676 D-loop; other site 1191061004677 H-loop/switch region; other site 1191061004678 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1191061004679 Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; cl02395 1191061004680 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1191061004681 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1191061004682 bacterial glycerol kinase 2-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK2_bacteria; cd07791 1191061004683 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 1191061004684 N- and C-terminal domain interface [polypeptide binding]; other site 1191061004685 active site 1191061004686 MgATP binding site [chemical binding]; other site 1191061004687 catalytic site [active] 1191061004688 metal binding site [ion binding]; metal-binding site 1191061004689 putative homotetramer interface [polypeptide binding]; other site 1191061004690 putative homodimer interface [polypeptide binding]; other site 1191061004691 glycerol binding site [chemical binding]; other site 1191061004692 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1191061004693 MarR family; Region: MarR_2; cl17246 1191061004694 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1191061004695 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1191061004696 TPP-binding site [chemical binding]; other site 1191061004697 dimer interface [polypeptide binding]; other site 1191061004698 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1191061004699 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1191061004700 PYR/PP interface [polypeptide binding]; other site 1191061004701 dimer interface [polypeptide binding]; other site 1191061004702 TPP binding site [chemical binding]; other site 1191061004703 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1191061004704 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 1191061004705 outer membrane receptor FepA; Provisional; Region: PRK13524 1191061004706 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1191061004707 N-terminal plug; other site 1191061004708 ligand-binding site [chemical binding]; other site 1191061004709 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 1191061004710 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 1191061004711 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1191061004712 MbtH-like protein; Region: MbtH; cl01279 1191061004713 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1191061004714 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1191061004715 acyl-activating enzyme (AAE) consensus motif; other site 1191061004716 AMP binding site [chemical binding]; other site 1191061004717 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1191061004718 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 1191061004719 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1191061004720 Walker A/P-loop; other site 1191061004721 ATP binding site [chemical binding]; other site 1191061004722 Q-loop/lid; other site 1191061004723 ABC transporter signature motif; other site 1191061004724 Walker B; other site 1191061004725 D-loop; other site 1191061004726 H-loop/switch region; other site 1191061004727 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1191061004728 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1191061004729 ABC-ATPase subunit interface; other site 1191061004730 dimer interface [polypeptide binding]; other site 1191061004731 putative PBP binding regions; other site 1191061004732 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1191061004733 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1191061004734 ABC-ATPase subunit interface; other site 1191061004735 dimer interface [polypeptide binding]; other site 1191061004736 putative PBP binding regions; other site 1191061004737 enterobactin exporter EntS; Provisional; Region: PRK10489 1191061004738 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061004739 putative substrate translocation pore; other site 1191061004740 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 1191061004741 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 1191061004742 active site 1191061004743 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 1191061004744 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1191061004745 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1191061004746 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 1191061004747 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1191061004748 siderophore binding site; other site 1191061004749 isochorismate synthase EntC; Provisional; Region: PRK15016 1191061004750 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1191061004751 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 1191061004752 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1191061004753 acyl-activating enzyme (AAE) consensus motif; other site 1191061004754 active site 1191061004755 AMP binding site [chemical binding]; other site 1191061004756 substrate binding site [chemical binding]; other site 1191061004757 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1191061004758 hydrophobic substrate binding pocket; other site 1191061004759 Isochorismatase family; Region: Isochorismatase; pfam00857 1191061004760 active site 1191061004761 conserved cis-peptide bond; other site 1191061004762 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1191061004763 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 1191061004764 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 1191061004765 putative NAD(P) binding site [chemical binding]; other site 1191061004766 active site 1191061004767 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1191061004768 CoenzymeA binding site [chemical binding]; other site 1191061004769 subunit interaction site [polypeptide binding]; other site 1191061004770 PHB binding site; other site 1191061004771 carbon starvation protein A; Provisional; Region: PRK15015 1191061004772 Carbon starvation protein CstA; Region: CstA; pfam02554 1191061004773 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1191061004774 Uncharacterized small protein [Function unknown]; Region: COG2879 1191061004775 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1191061004776 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1191061004777 salt bridge; other site 1191061004778 non-specific DNA binding site [nucleotide binding]; other site 1191061004779 sequence-specific DNA binding site [nucleotide binding]; other site 1191061004780 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1191061004781 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 1191061004782 putative active site [active] 1191061004783 metal binding site [ion binding]; metal-binding site 1191061004784 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1191061004785 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1191061004786 Walker A/P-loop; other site 1191061004787 ATP binding site [chemical binding]; other site 1191061004788 Q-loop/lid; other site 1191061004789 ABC transporter signature motif; other site 1191061004790 Walker B; other site 1191061004791 D-loop; other site 1191061004792 H-loop/switch region; other site 1191061004793 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1191061004794 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1191061004795 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1191061004796 TM-ABC transporter signature motif; other site 1191061004797 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 1191061004798 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1191061004799 putative ligand binding site [chemical binding]; other site 1191061004800 Uncharacterized conserved protein [Function unknown]; Region: COG5276 1191061004801 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 1191061004802 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 1191061004803 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1191061004804 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 1191061004805 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1191061004806 catalytic core [active] 1191061004807 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1191061004808 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 1191061004809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061004810 putative substrate translocation pore; other site 1191061004811 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1191061004812 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1191061004813 active site 1191061004814 cytosine deaminase; Provisional; Region: PRK09230 1191061004815 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1191061004816 active site 1191061004817 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1191061004818 DRTGG domain; Region: DRTGG; pfam07085 1191061004819 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1191061004820 cytosine permease; Provisional; Region: codB; PRK11017 1191061004821 Na binding site [ion binding]; other site 1191061004822 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 1191061004823 intersubunit interface [polypeptide binding]; other site 1191061004824 active site 1191061004825 Zn2+ binding site [ion binding]; other site 1191061004826 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1191061004827 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 1191061004828 putative N- and C-terminal domain interface [polypeptide binding]; other site 1191061004829 putative active site [active] 1191061004830 MgATP binding site [chemical binding]; other site 1191061004831 catalytic site [active] 1191061004832 metal binding site [ion binding]; metal-binding site 1191061004833 putative xylulose binding site [chemical binding]; other site 1191061004834 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1191061004835 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 1191061004836 putative ligand binding site [chemical binding]; other site 1191061004837 putative NAD binding site [chemical binding]; other site 1191061004838 catalytic site [active] 1191061004839 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1191061004840 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1191061004841 substrate binding site [chemical binding]; other site 1191061004842 ATP binding site [chemical binding]; other site 1191061004843 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1191061004844 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1191061004845 TM-ABC transporter signature motif; other site 1191061004846 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1191061004847 TM-ABC transporter signature motif; other site 1191061004848 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1191061004849 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1191061004850 Walker A/P-loop; other site 1191061004851 ATP binding site [chemical binding]; other site 1191061004852 Q-loop/lid; other site 1191061004853 ABC transporter signature motif; other site 1191061004854 Walker B; other site 1191061004855 D-loop; other site 1191061004856 H-loop/switch region; other site 1191061004857 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1191061004858 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 1191061004859 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1191061004860 putative ligand binding site [chemical binding]; other site 1191061004861 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1191061004862 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1191061004863 molybdopterin cofactor binding site [chemical binding]; other site 1191061004864 substrate binding site [chemical binding]; other site 1191061004865 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1191061004866 molybdopterin cofactor binding site; other site 1191061004867 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1191061004868 Cupin domain; Region: Cupin_2; cl17218 1191061004869 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691 1191061004870 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1191061004871 motif II; other site 1191061004872 methionine aminotransferase; Validated; Region: PRK09082 1191061004873 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1191061004874 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061004875 homodimer interface [polypeptide binding]; other site 1191061004876 catalytic residue [active] 1191061004877 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1191061004878 ParB-like nuclease domain; Region: ParBc; pfam02195 1191061004879 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 1191061004880 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1191061004881 Active Sites [active] 1191061004882 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 1191061004883 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061004884 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061004885 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1191061004886 dimerization interface [polypeptide binding]; other site 1191061004887 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 1191061004888 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1191061004889 dimer interface [polypeptide binding]; other site 1191061004890 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1191061004891 catalytic triad [active] 1191061004892 peroxidatic and resolving cysteines [active] 1191061004893 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1191061004894 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1191061004895 catalytic residue [active] 1191061004896 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1191061004897 catalytic residues [active] 1191061004898 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1191061004899 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1191061004900 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1191061004901 Ligand Binding Site [chemical binding]; other site 1191061004902 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 1191061004903 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1191061004904 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 1191061004905 B1 nucleotide binding pocket [chemical binding]; other site 1191061004906 B2 nucleotide binding pocket [chemical binding]; other site 1191061004907 CAS motifs; other site 1191061004908 active site 1191061004909 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 1191061004910 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1191061004911 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 1191061004912 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1191061004913 DNA-binding site [nucleotide binding]; DNA binding site 1191061004914 RNA-binding motif; other site 1191061004915 chromosome condensation membrane protein; Provisional; Region: PRK14196 1191061004916 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1191061004917 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1191061004918 putative active site [active] 1191061004919 catalytic triad [active] 1191061004920 putative dimer interface [polypeptide binding]; other site 1191061004921 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 1191061004922 lipoyl synthase; Provisional; Region: PRK05481 1191061004923 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1191061004924 FeS/SAM binding site; other site 1191061004925 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 1191061004926 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061004927 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1191061004928 substrate binding pocket [chemical binding]; other site 1191061004929 dimerization interface [polypeptide binding]; other site 1191061004930 lipoate-protein ligase B; Provisional; Region: PRK14342 1191061004931 hypothetical protein; Provisional; Region: PRK04998 1191061004932 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 1191061004933 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1191061004934 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1191061004935 rare lipoprotein A; Provisional; Region: PRK10672 1191061004936 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1191061004937 Sporulation related domain; Region: SPOR; pfam05036 1191061004938 cell wall shape-determining protein; Provisional; Region: PRK10794 1191061004939 penicillin-binding protein 2; Provisional; Region: PRK10795 1191061004940 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1191061004941 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1191061004942 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 1191061004943 ribosome-associated protein; Provisional; Region: PRK11538 1191061004944 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1191061004945 catalytic core [active] 1191061004946 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1191061004947 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1191061004948 active site 1191061004949 (T/H)XGH motif; other site 1191061004950 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1191061004951 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1191061004952 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 1191061004953 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1191061004954 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1191061004955 HIGH motif; other site 1191061004956 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1191061004957 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1191061004958 active site 1191061004959 KMSKS motif; other site 1191061004960 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1191061004961 tRNA binding surface [nucleotide binding]; other site 1191061004962 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1191061004963 hypothetical protein; Provisional; Region: PRK11032 1191061004964 SPX domain; Region: SPX; pfam03105 1191061004965 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1191061004966 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1191061004967 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1191061004968 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 1191061004969 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1191061004970 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1191061004971 Walker A/P-loop; other site 1191061004972 ATP binding site [chemical binding]; other site 1191061004973 Q-loop/lid; other site 1191061004974 ABC transporter signature motif; other site 1191061004975 Walker B; other site 1191061004976 D-loop; other site 1191061004977 H-loop/switch region; other site 1191061004978 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061004979 dimer interface [polypeptide binding]; other site 1191061004980 conserved gate region; other site 1191061004981 putative PBP binding loops; other site 1191061004982 ABC-ATPase subunit interface; other site 1191061004983 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1191061004984 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061004985 dimer interface [polypeptide binding]; other site 1191061004986 conserved gate region; other site 1191061004987 putative PBP binding loops; other site 1191061004988 ABC-ATPase subunit interface; other site 1191061004989 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 1191061004990 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1191061004991 substrate binding pocket [chemical binding]; other site 1191061004992 membrane-bound complex binding site; other site 1191061004993 hinge residues; other site 1191061004994 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1191061004995 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1191061004996 putative active site [active] 1191061004997 catalytic triad [active] 1191061004998 putative dimer interface [polypeptide binding]; other site 1191061004999 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 1191061005000 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1191061005001 Transporter associated domain; Region: CorC_HlyC; smart01091 1191061005002 metal-binding heat shock protein; Provisional; Region: PRK00016 1191061005003 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1191061005004 PhoH-like protein; Region: PhoH; pfam02562 1191061005005 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1191061005006 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1191061005007 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1191061005008 FeS/SAM binding site; other site 1191061005009 TRAM domain; Region: TRAM; pfam01938 1191061005010 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 1191061005011 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1191061005012 asparagine synthetase B; Provisional; Region: asnB; PRK09431 1191061005013 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1191061005014 active site 1191061005015 dimer interface [polypeptide binding]; other site 1191061005016 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1191061005017 Ligand Binding Site [chemical binding]; other site 1191061005018 Molecular Tunnel; other site 1191061005019 UMP phosphatase; Provisional; Region: PRK10444 1191061005020 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1191061005021 active site 1191061005022 motif I; other site 1191061005023 motif II; other site 1191061005024 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1191061005025 MarR family; Region: MarR; pfam01047 1191061005026 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1191061005027 ROK family; Region: ROK; pfam00480 1191061005028 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 1191061005029 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1191061005030 active site 1191061005031 dimer interface [polypeptide binding]; other site 1191061005032 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1191061005033 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1191061005034 active site 1191061005035 trimer interface [polypeptide binding]; other site 1191061005036 allosteric site; other site 1191061005037 active site lid [active] 1191061005038 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1191061005039 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 1191061005040 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1191061005041 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1191061005042 active site turn [active] 1191061005043 phosphorylation site [posttranslational modification] 1191061005044 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1191061005045 HPr interaction site; other site 1191061005046 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1191061005047 active site 1191061005048 phosphorylation site [posttranslational modification] 1191061005049 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1191061005050 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1191061005051 active site 1191061005052 HIGH motif; other site 1191061005053 nucleotide binding site [chemical binding]; other site 1191061005054 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1191061005055 KMSKS motif; other site 1191061005056 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1191061005057 outer membrane porin, OprD family; Region: OprD; pfam03573 1191061005058 YbfN-like lipoprotein; Region: YbfN; pfam13982 1191061005059 citrate-proton symporter; Provisional; Region: PRK15075 1191061005060 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061005061 putative substrate translocation pore; other site 1191061005062 tricarballylate utilization protein B; Provisional; Region: PRK15033 1191061005063 tricarballylate dehydrogenase; Validated; Region: PRK08274 1191061005064 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1191061005065 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1191061005066 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 1191061005067 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061005068 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 1191061005069 putative dimerization interface [polypeptide binding]; other site 1191061005070 ferric uptake regulator; Provisional; Region: fur; PRK09462 1191061005071 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1191061005072 metal binding site 2 [ion binding]; metal-binding site 1191061005073 putative DNA binding helix; other site 1191061005074 metal binding site 1 [ion binding]; metal-binding site 1191061005075 dimer interface [polypeptide binding]; other site 1191061005076 structural Zn2+ binding site [ion binding]; other site 1191061005077 flavodoxin FldA; Validated; Region: PRK09267 1191061005078 LexA regulated protein; Provisional; Region: PRK11675 1191061005079 acyl-CoA esterase; Provisional; Region: PRK10673 1191061005080 PGAP1-like protein; Region: PGAP1; pfam07819 1191061005081 replication initiation regulator SeqA; Provisional; Region: PRK11187 1191061005082 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 1191061005083 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1191061005084 active site 1191061005085 substrate binding site [chemical binding]; other site 1191061005086 metal binding site [ion binding]; metal-binding site 1191061005087 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1191061005088 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1191061005089 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1191061005090 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1191061005091 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1191061005092 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1191061005093 NAD(P) binding site [chemical binding]; other site 1191061005094 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1191061005095 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 1191061005096 putative ligand binding site [chemical binding]; other site 1191061005097 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1191061005098 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1191061005099 Walker A/P-loop; other site 1191061005100 ATP binding site [chemical binding]; other site 1191061005101 Q-loop/lid; other site 1191061005102 ABC transporter signature motif; other site 1191061005103 Walker B; other site 1191061005104 D-loop; other site 1191061005105 H-loop/switch region; other site 1191061005106 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1191061005107 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1191061005108 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1191061005109 TM-ABC transporter signature motif; other site 1191061005110 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1191061005111 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 1191061005112 putative N- and C-terminal domain interface [polypeptide binding]; other site 1191061005113 putative active site [active] 1191061005114 MgATP binding site [chemical binding]; other site 1191061005115 catalytic site [active] 1191061005116 metal binding site [ion binding]; metal-binding site 1191061005117 putative xylulose binding site [chemical binding]; other site 1191061005118 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 1191061005119 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1191061005120 AP (apurinic/apyrimidinic) site pocket; other site 1191061005121 DNA interaction; other site 1191061005122 Metal-binding active site; metal-binding site 1191061005123 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1191061005124 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1191061005125 intersubunit interface [polypeptide binding]; other site 1191061005126 active site 1191061005127 Zn2+ binding site [ion binding]; other site 1191061005128 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1191061005129 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191061005130 active site 1191061005131 phosphorylation site [posttranslational modification] 1191061005132 intermolecular recognition site; other site 1191061005133 dimerization interface [polypeptide binding]; other site 1191061005134 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1191061005135 DNA binding site [nucleotide binding] 1191061005136 sensor protein KdpD; Provisional; Region: PRK10490 1191061005137 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1191061005138 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1191061005139 Ligand Binding Site [chemical binding]; other site 1191061005140 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1191061005141 GAF domain; Region: GAF_3; pfam13492 1191061005142 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191061005143 dimer interface [polypeptide binding]; other site 1191061005144 phosphorylation site [posttranslational modification] 1191061005145 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191061005146 ATP binding site [chemical binding]; other site 1191061005147 Mg2+ binding site [ion binding]; other site 1191061005148 G-X-G motif; other site 1191061005149 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 1191061005150 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1191061005151 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1191061005152 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1191061005153 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 1191061005154 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 1191061005155 DNA photolyase; Region: DNA_photolyase; pfam00875 1191061005156 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1191061005157 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061005158 putative substrate translocation pore; other site 1191061005159 POT family; Region: PTR2; pfam00854 1191061005160 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1191061005161 metal-binding protein; Provisional; Region: PRK10799 1191061005162 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1191061005163 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1191061005164 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 1191061005165 putative active site [active] 1191061005166 Protein of unknown function (DUF969); Region: DUF969; pfam06149 1191061005167 Predicted membrane protein [Function unknown]; Region: COG3817 1191061005168 Protein of unknown function (DUF979); Region: DUF979; pfam06166 1191061005169 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1191061005170 putative substrate binding pocket [chemical binding]; other site 1191061005171 AC domain interface; other site 1191061005172 catalytic triad [active] 1191061005173 AB domain interface; other site 1191061005174 interchain disulfide; other site 1191061005175 endonuclease VIII; Provisional; Region: PRK10445 1191061005176 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 1191061005177 DNA binding site [nucleotide binding] 1191061005178 catalytic residue [active] 1191061005179 putative catalytic residues [active] 1191061005180 H2TH interface [polypeptide binding]; other site 1191061005181 intercalation triad [nucleotide binding]; other site 1191061005182 substrate specificity determining residue; other site 1191061005183 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1191061005184 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1191061005185 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1191061005186 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1191061005187 dimer interface [polypeptide binding]; other site 1191061005188 active site 1191061005189 citrylCoA binding site [chemical binding]; other site 1191061005190 NADH binding [chemical binding]; other site 1191061005191 cationic pore residues; other site 1191061005192 oxalacetate/citrate binding site [chemical binding]; other site 1191061005193 coenzyme A binding site [chemical binding]; other site 1191061005194 catalytic triad [active] 1191061005195 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1191061005196 Iron-sulfur protein interface; other site 1191061005197 proximal quinone binding site [chemical binding]; other site 1191061005198 SdhD (CybS) interface [polypeptide binding]; other site 1191061005199 proximal heme binding site [chemical binding]; other site 1191061005200 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 1191061005201 SdhC subunit interface [polypeptide binding]; other site 1191061005202 proximal heme binding site [chemical binding]; other site 1191061005203 cardiolipin binding site; other site 1191061005204 Iron-sulfur protein interface; other site 1191061005205 proximal quinone binding site [chemical binding]; other site 1191061005206 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 1191061005207 L-aspartate oxidase; Provisional; Region: PRK06175 1191061005208 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1191061005209 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1191061005210 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1191061005211 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1191061005212 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1191061005213 TPP-binding site [chemical binding]; other site 1191061005214 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1191061005215 dimer interface [polypeptide binding]; other site 1191061005216 PYR/PP interface [polypeptide binding]; other site 1191061005217 TPP binding site [chemical binding]; other site 1191061005218 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1191061005219 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1191061005220 E3 interaction surface; other site 1191061005221 lipoyl attachment site [posttranslational modification]; other site 1191061005222 e3 binding domain; Region: E3_binding; pfam02817 1191061005223 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1191061005224 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1191061005225 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1191061005226 CoA-ligase; Region: Ligase_CoA; pfam00549 1191061005227 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1191061005228 CoA binding domain; Region: CoA_binding; smart00881 1191061005229 CoA-ligase; Region: Ligase_CoA; pfam00549 1191061005230 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1191061005231 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061005232 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1191061005233 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1191061005234 dimerization interface [polypeptide binding]; other site 1191061005235 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1191061005236 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1191061005237 homodimer interface [polypeptide binding]; other site 1191061005238 Walker A motif; other site 1191061005239 ATP binding site [chemical binding]; other site 1191061005240 hydroxycobalamin binding site [chemical binding]; other site 1191061005241 Walker B motif; other site 1191061005242 putative fumarate hydratase; Provisional; Region: PRK15392 1191061005243 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 1191061005244 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1191061005245 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1191061005246 Glutaminase; Region: Glutaminase; cl00907 1191061005247 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1191061005248 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1191061005249 Domain of unknown function (DUF4387); Region: DUF4387; pfam14330 1191061005250 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1191061005251 Methylaspartate ammonia-lyase [Amino acid transport and metabolism]; Region: Mal; COG3799 1191061005252 Methylaspartate ammonia lyase (3-methylaspartase, MAL) is a homodimeric enzyme, catalyzing the magnesium-dependent reversible alpha,beta-elimination of ammonia from L-threo-(2S,3S)-3-methylaspartic acid to mesaconic acid. This reaction is part of the...; Region: MAL; cd03314 1191061005253 dimer interface [polypeptide binding]; other site 1191061005254 active site 1191061005255 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cd00245 1191061005256 substrate binding site [chemical binding]; other site 1191061005257 B12 cofactor binding site [chemical binding]; other site 1191061005258 heterodimer (sigma-epsilon) interface [polypeptide binding]; other site 1191061005259 homodimer (epsilon-epsilon) interface [polypeptide binding]; other site 1191061005260 conserved hypothetical protein; Region: glmL_fam; TIGR01319 1191061005261 B12 binding domain of glutamate mutase (Glm). Glutamate mutase catalysis the conversion of (S)-glutamate with (2S,3S)-3-methylaspartate. The rearrangement reaction is initiated by the extraction of a hydrogen from the protein-bound substrate by a 5'...; Region: Glm_B12_BD; cd02072 1191061005262 B12 binding site [chemical binding]; other site 1191061005263 heterodimer interface [polypeptide binding]; other site 1191061005264 cobalt ligand [ion binding]; other site 1191061005265 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1191061005266 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1191061005267 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 1191061005268 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1191061005269 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 1191061005270 hypothetical protein; Provisional; Region: PRK10588 1191061005271 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1191061005272 active site 1191061005273 colicin uptake protein TolQ; Provisional; Region: PRK10801 1191061005274 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1191061005275 colicin uptake protein TolR; Provisional; Region: PRK11024 1191061005276 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 1191061005277 TolA C-terminal; Region: TolA; pfam06519 1191061005278 translocation protein TolB; Provisional; Region: tolB; PRK03629 1191061005279 TolB amino-terminal domain; Region: TolB_N; pfam04052 1191061005280 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1191061005281 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1191061005282 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 1191061005283 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1191061005284 ligand binding site [chemical binding]; other site 1191061005285 tol-pal system protein YbgF; Provisional; Region: PRK10803 1191061005286 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1191061005287 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1191061005288 quinolinate synthetase; Provisional; Region: PRK09375 1191061005289 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 1191061005290 zinc transporter ZitB; Provisional; Region: PRK03557 1191061005291 YbgS-like protein; Region: YbgS; pfam13985 1191061005292 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1191061005293 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1191061005294 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1191061005295 catalytic core [active] 1191061005296 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1191061005297 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1191061005298 active site 1191061005299 catalytic residues [active] 1191061005300 galactokinase; Provisional; Region: PRK05101 1191061005301 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1191061005302 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1191061005303 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1191061005304 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 1191061005305 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1191061005306 dimer interface [polypeptide binding]; other site 1191061005307 active site 1191061005308 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 1191061005309 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1191061005310 NAD binding site [chemical binding]; other site 1191061005311 homodimer interface [polypeptide binding]; other site 1191061005312 active site 1191061005313 substrate binding site [chemical binding]; other site 1191061005314 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 1191061005315 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1191061005316 Walker A/P-loop; other site 1191061005317 ATP binding site [chemical binding]; other site 1191061005318 Q-loop/lid; other site 1191061005319 ABC transporter signature motif; other site 1191061005320 Walker B; other site 1191061005321 D-loop; other site 1191061005322 H-loop/switch region; other site 1191061005323 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1191061005324 Walker A/P-loop; other site 1191061005325 ATP binding site [chemical binding]; other site 1191061005326 Q-loop/lid; other site 1191061005327 ABC transporter signature motif; other site 1191061005328 Walker B; other site 1191061005329 D-loop; other site 1191061005330 H-loop/switch region; other site 1191061005331 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 1191061005332 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 1191061005333 TOBE domain; Region: TOBE; cl01440 1191061005334 TOBE domain; Region: TOBE; pfam03459 1191061005335 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 1191061005336 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 1191061005337 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1191061005338 substrate binding pocket [chemical binding]; other site 1191061005339 membrane-bound complex binding site; other site 1191061005340 hinge residues; other site 1191061005341 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1191061005342 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061005343 dimer interface [polypeptide binding]; other site 1191061005344 conserved gate region; other site 1191061005345 putative PBP binding loops; other site 1191061005346 ABC-ATPase subunit interface; other site 1191061005347 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 1191061005348 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1191061005349 Walker A/P-loop; other site 1191061005350 ATP binding site [chemical binding]; other site 1191061005351 Q-loop/lid; other site 1191061005352 ABC transporter signature motif; other site 1191061005353 Walker B; other site 1191061005354 D-loop; other site 1191061005355 H-loop/switch region; other site 1191061005356 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1191061005357 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 1191061005358 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1191061005359 active site 1191061005360 motif I; other site 1191061005361 motif II; other site 1191061005362 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1191061005363 6-phosphogluconolactonase; Provisional; Region: PRK11028 1191061005364 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1191061005365 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1191061005366 Coenzyme A binding pocket [chemical binding]; other site 1191061005367 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1191061005368 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1191061005369 DNA-binding site [nucleotide binding]; DNA binding site 1191061005370 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1191061005371 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061005372 homodimer interface [polypeptide binding]; other site 1191061005373 catalytic residue [active] 1191061005374 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 1191061005375 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 1191061005376 Sensors of blue-light using FAD; Region: BLUF; smart01034 1191061005377 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1191061005378 transcriptional regulator MirA; Provisional; Region: PRK15043 1191061005379 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1191061005380 DNA binding residues [nucleotide binding] 1191061005381 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1191061005382 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 1191061005383 DNA binding residues [nucleotide binding] 1191061005384 dimerization interface [polypeptide binding]; other site 1191061005385 acyl-CoA thioesterase; Provisional; Region: PRK10531 1191061005386 putative pectinesterase; Region: PLN02432; cl01911 1191061005387 imidazolonepropionase; Validated; Region: PRK09356 1191061005388 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1191061005389 active site 1191061005390 histidine utilization repressor; Provisional; Region: PRK14999 1191061005391 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1191061005392 DNA-binding site [nucleotide binding]; DNA binding site 1191061005393 UTRA domain; Region: UTRA; pfam07702 1191061005394 urocanate hydratase; Provisional; Region: PRK05414 1191061005395 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1191061005396 active sites [active] 1191061005397 tetramer interface [polypeptide binding]; other site 1191061005398 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1191061005399 substrate binding site [chemical binding]; other site 1191061005400 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 1191061005401 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1191061005402 inhibitor-cofactor binding pocket; inhibition site 1191061005403 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061005404 catalytic residue [active] 1191061005405 biotin synthase; Provisional; Region: PRK15108 1191061005406 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1191061005407 FeS/SAM binding site; other site 1191061005408 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1191061005409 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1191061005410 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1191061005411 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1191061005412 catalytic residue [active] 1191061005413 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1191061005414 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191061005415 S-adenosylmethionine binding site [chemical binding]; other site 1191061005416 AAA domain; Region: AAA_26; pfam13500 1191061005417 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1191061005418 excinuclease ABC subunit B; Provisional; Region: PRK05298 1191061005419 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1191061005420 ATP binding site [chemical binding]; other site 1191061005421 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1191061005422 nucleotide binding region [chemical binding]; other site 1191061005423 ATP-binding site [chemical binding]; other site 1191061005424 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1191061005425 UvrB/uvrC motif; Region: UVR; pfam02151 1191061005426 sensor protein BasS/PmrB; Provisional; Region: PRK10755 1191061005427 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1191061005428 dimer interface [polypeptide binding]; other site 1191061005429 phosphorylation site [posttranslational modification] 1191061005430 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191061005431 ATP binding site [chemical binding]; other site 1191061005432 Mg2+ binding site [ion binding]; other site 1191061005433 G-X-G motif; other site 1191061005434 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 1191061005435 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191061005436 active site 1191061005437 phosphorylation site [posttranslational modification] 1191061005438 intermolecular recognition site; other site 1191061005439 dimerization interface [polypeptide binding]; other site 1191061005440 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1191061005441 DNA binding site [nucleotide binding] 1191061005442 putative metal dependent hydrolase; Provisional; Region: PRK11598 1191061005443 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1191061005444 Sulfatase; Region: Sulfatase; pfam00884 1191061005445 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1191061005446 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1191061005447 phosphate binding site [ion binding]; other site 1191061005448 putative substrate binding pocket [chemical binding]; other site 1191061005449 dimer interface [polypeptide binding]; other site 1191061005450 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1191061005451 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1191061005452 FeS/SAM binding site; other site 1191061005453 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1191061005454 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1191061005455 MPT binding site; other site 1191061005456 trimer interface [polypeptide binding]; other site 1191061005457 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1191061005458 trimer interface [polypeptide binding]; other site 1191061005459 dimer interface [polypeptide binding]; other site 1191061005460 putative active site [active] 1191061005461 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1191061005462 MoaE interaction surface [polypeptide binding]; other site 1191061005463 MoeB interaction surface [polypeptide binding]; other site 1191061005464 thiocarboxylated glycine; other site 1191061005465 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1191061005466 MoaE homodimer interface [polypeptide binding]; other site 1191061005467 MoaD interaction [polypeptide binding]; other site 1191061005468 active site residues [active] 1191061005469 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1191061005470 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1191061005471 Predicted integral membrane protein [Function unknown]; Region: COG0392 1191061005472 cardiolipin synthase 2; Provisional; Region: PRK11263 1191061005473 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1191061005474 putative active site [active] 1191061005475 catalytic site [active] 1191061005476 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 1191061005477 putative active site [active] 1191061005478 catalytic site [active] 1191061005479 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 1191061005480 putative catalytic site [active] 1191061005481 putative metal binding site [ion binding]; other site 1191061005482 putative phosphate binding site [ion binding]; other site 1191061005483 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 1191061005484 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1191061005485 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1191061005486 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1191061005487 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1191061005488 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1191061005489 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1191061005490 Walker A/P-loop; other site 1191061005491 ATP binding site [chemical binding]; other site 1191061005492 Q-loop/lid; other site 1191061005493 ABC transporter signature motif; other site 1191061005494 Walker B; other site 1191061005495 D-loop; other site 1191061005496 H-loop/switch region; other site 1191061005497 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1191061005498 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1191061005499 Walker A/P-loop; other site 1191061005500 ATP binding site [chemical binding]; other site 1191061005501 Q-loop/lid; other site 1191061005502 ABC transporter signature motif; other site 1191061005503 Walker B; other site 1191061005504 D-loop; other site 1191061005505 H-loop/switch region; other site 1191061005506 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 1191061005507 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1191061005508 HlyD family secretion protein; Region: HlyD_3; pfam13437 1191061005509 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 1191061005510 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1191061005511 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 1191061005512 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1191061005513 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061005514 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1191061005515 dimerization interface [polypeptide binding]; other site 1191061005516 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061005517 D-galactonate transporter; Region: 2A0114; TIGR00893 1191061005518 putative substrate translocation pore; other site 1191061005519 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061005520 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1191061005521 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1191061005522 NAD(P) binding site [chemical binding]; other site 1191061005523 active site 1191061005524 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1191061005525 TPP-binding site [chemical binding]; other site 1191061005526 dimer interface [polypeptide binding]; other site 1191061005527 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1191061005528 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1191061005529 PYR/PP interface [polypeptide binding]; other site 1191061005530 dimer interface [polypeptide binding]; other site 1191061005531 TPP binding site [chemical binding]; other site 1191061005532 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1191061005533 helicase 45; Provisional; Region: PTZ00424 1191061005534 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1191061005535 ATP binding site [chemical binding]; other site 1191061005536 Mg++ binding site [ion binding]; other site 1191061005537 motif III; other site 1191061005538 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1191061005539 nucleotide binding region [chemical binding]; other site 1191061005540 ATP-binding site [chemical binding]; other site 1191061005541 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 1191061005542 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1191061005543 DEAD_2; Region: DEAD_2; pfam06733 1191061005544 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1191061005545 glycosyl transferase family protein; Provisional; Region: PRK08136 1191061005546 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1191061005547 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 1191061005548 hypothetical protein; Provisional; Region: PRK11019 1191061005549 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 1191061005550 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 1191061005551 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1191061005552 N-terminal plug; other site 1191061005553 ligand-binding site [chemical binding]; other site 1191061005554 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1191061005555 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 1191061005556 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191061005557 S-adenosylmethionine binding site [chemical binding]; other site 1191061005558 putative mechanosensitive channel protein; Provisional; Region: PRK11465 1191061005559 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1191061005560 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 1191061005561 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 1191061005562 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1191061005563 Autotransporter beta-domain; Region: Autotransporter; smart00869 1191061005564 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 1191061005565 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1191061005566 Walker A/P-loop; other site 1191061005567 ATP binding site [chemical binding]; other site 1191061005568 Q-loop/lid; other site 1191061005569 ABC transporter signature motif; other site 1191061005570 Walker B; other site 1191061005571 D-loop; other site 1191061005572 H-loop/switch region; other site 1191061005573 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1191061005574 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061005575 dimer interface [polypeptide binding]; other site 1191061005576 conserved gate region; other site 1191061005577 putative PBP binding loops; other site 1191061005578 ABC-ATPase subunit interface; other site 1191061005579 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 1191061005580 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1191061005581 substrate binding pocket [chemical binding]; other site 1191061005582 membrane-bound complex binding site; other site 1191061005583 hinge residues; other site 1191061005584 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1191061005585 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1191061005586 dimerization interface [polypeptide binding]; other site 1191061005587 DPS ferroxidase diiron center [ion binding]; other site 1191061005588 ion pore; other site 1191061005589 threonine and homoserine efflux system; Provisional; Region: PRK10532 1191061005590 EamA-like transporter family; Region: EamA; cl17759 1191061005591 outer membrane protein X; Provisional; Region: ompX; PRK09408 1191061005592 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 1191061005593 Sulfatase; Region: Sulfatase; pfam00884 1191061005594 manganese transport regulator MntR; Provisional; Region: PRK11050 1191061005595 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1191061005596 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1191061005597 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 1191061005598 transmembrane helices; other site 1191061005599 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1191061005600 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1191061005601 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1191061005602 active site 1191061005603 catalytic tetrad [active] 1191061005604 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1191061005605 beta-galactosidase; Region: BGL; TIGR03356 1191061005606 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1191061005607 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1191061005608 DNA-binding site [nucleotide binding]; DNA binding site 1191061005609 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1191061005610 L,D-transpeptidase; Provisional; Region: PRK10260 1191061005611 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1191061005612 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1191061005613 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1191061005614 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1191061005615 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1191061005616 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1191061005617 Walker A/P-loop; other site 1191061005618 ATP binding site [chemical binding]; other site 1191061005619 Q-loop/lid; other site 1191061005620 ABC transporter signature motif; other site 1191061005621 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1191061005622 Walker B; other site 1191061005623 D-loop; other site 1191061005624 ABC transporter; Region: ABC_tran_2; pfam12848 1191061005625 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1191061005626 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1191061005627 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1191061005628 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 1191061005629 putative active site [active] 1191061005630 putative catalytic site [active] 1191061005631 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061005632 D-galactonate transporter; Region: 2A0114; TIGR00893 1191061005633 putative substrate translocation pore; other site 1191061005634 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1191061005635 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1191061005636 DNA binding site [nucleotide binding] 1191061005637 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1191061005638 ligand binding site [chemical binding]; other site 1191061005639 dimerization interface [polypeptide binding]; other site 1191061005640 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 1191061005641 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1191061005642 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1191061005643 active site 1191061005644 motif I; other site 1191061005645 motif II; other site 1191061005646 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1191061005647 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 1191061005648 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 1191061005649 dimer interface [polypeptide binding]; other site 1191061005650 active site 1191061005651 glycine loop; other site 1191061005652 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 1191061005653 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1191061005654 FeS/SAM binding site; other site 1191061005655 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1191061005656 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1191061005657 ATP binding site [chemical binding]; other site 1191061005658 substrate interface [chemical binding]; other site 1191061005659 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 1191061005660 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1191061005661 dimer interface [polypeptide binding]; other site 1191061005662 putative functional site; other site 1191061005663 putative MPT binding site; other site 1191061005664 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 1191061005665 catalytic nucleophile [active] 1191061005666 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1191061005667 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1191061005668 Walker A/P-loop; other site 1191061005669 ATP binding site [chemical binding]; other site 1191061005670 Q-loop/lid; other site 1191061005671 ABC transporter signature motif; other site 1191061005672 Walker B; other site 1191061005673 D-loop; other site 1191061005674 H-loop/switch region; other site 1191061005675 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1191061005676 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1191061005677 Walker A/P-loop; other site 1191061005678 ATP binding site [chemical binding]; other site 1191061005679 Q-loop/lid; other site 1191061005680 ABC transporter signature motif; other site 1191061005681 Walker B; other site 1191061005682 D-loop; other site 1191061005683 H-loop/switch region; other site 1191061005684 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1191061005685 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 1191061005686 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 1191061005687 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 1191061005688 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061005689 dimer interface [polypeptide binding]; other site 1191061005690 conserved gate region; other site 1191061005691 putative PBP binding loops; other site 1191061005692 ABC-ATPase subunit interface; other site 1191061005693 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 1191061005694 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1191061005695 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061005696 dimer interface [polypeptide binding]; other site 1191061005697 conserved gate region; other site 1191061005698 putative PBP binding loops; other site 1191061005699 ABC-ATPase subunit interface; other site 1191061005700 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 1191061005701 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1191061005702 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1191061005703 FeS/SAM binding site; other site 1191061005704 galactoside permease; Reviewed; Region: lacY; PRK09528 1191061005705 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061005706 putative substrate translocation pore; other site 1191061005707 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 1191061005708 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1191061005709 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1191061005710 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1191061005711 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 1191061005712 putative C-terminal domain interface [polypeptide binding]; other site 1191061005713 putative GSH binding site (G-site) [chemical binding]; other site 1191061005714 putative dimer interface [polypeptide binding]; other site 1191061005715 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 1191061005716 putative N-terminal domain interface [polypeptide binding]; other site 1191061005717 putative dimer interface [polypeptide binding]; other site 1191061005718 putative substrate binding pocket (H-site) [chemical binding]; other site 1191061005719 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 1191061005720 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1191061005721 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 1191061005722 Int/Topo IB signature motif; other site 1191061005723 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 1191061005724 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1191061005725 DinI-like family; Region: DinI; cl11630 1191061005726 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 1191061005727 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869 1191061005728 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1191061005729 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1191061005730 cofactor binding site; other site 1191061005731 DNA binding site [nucleotide binding] 1191061005732 substrate interaction site [chemical binding]; other site 1191061005733 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1191061005734 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 1191061005735 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 1191061005736 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 1191061005737 Terminase small subunit; Region: Terminase_2; cl01513 1191061005738 Terminase-like family; Region: Terminase_6; pfam03237 1191061005739 hypothetical protein; Region: PHA00670 1191061005740 Bacteriophage head to tail connecting protein; Region: Head-tail_con; pfam12236 1191061005741 hypothetical protein; Region: PHA00662 1191061005742 hypothetical protein; Region: PHA00661 1191061005743 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1191061005744 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1191061005745 catalytic residue [active] 1191061005746 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 1191061005747 structural protein; Region: PHA01972 1191061005748 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1191061005749 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1191061005750 Integrase core domain; Region: rve; pfam00665 1191061005751 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; pfam04655 1191061005752 dihydropteroate synthase; Region: DHPS; TIGR01496 1191061005753 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1191061005754 substrate binding pocket [chemical binding]; other site 1191061005755 dimer interface [polypeptide binding]; other site 1191061005756 inhibitor binding site; inhibition site 1191061005757 Replication protein C (RepC); Region: RepC; pfam06504 1191061005758 Hexameric Replicative Helicase RepA. RepA is encoded by a plasmid, which is found in most Gram negative bacteria. RepA is a 5'-3' DNA helicase which can utilize ATP, GTP and CTP to a lesser extent; Region: repA; cd01125 1191061005759 AAA domain; Region: AAA_25; pfam13481 1191061005760 hexamer interface [polypeptide binding]; other site 1191061005761 NTP binding site [chemical binding]; other site 1191061005762 Walker B motif; other site 1191061005763 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1191061005764 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1191061005765 Integrase core domain; Region: rve; pfam00665 1191061005766 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 1191061005767 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 1191061005768 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1191061005769 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1191061005770 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1191061005771 Integrase core domain; Region: rve; pfam00665 1191061005772 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1191061005773 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1191061005774 Integrase core domain; Region: rve; pfam00665 1191061005775 integrase/recombinase; Provisional; Region: PRK15417 1191061005776 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 1191061005777 Int/Topo IB signature motif; other site 1191061005778 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 1191061005779 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1191061005780 dihydropteroate synthase; Region: DHPS; TIGR01496 1191061005781 substrate binding pocket [chemical binding]; other site 1191061005782 dimer interface [polypeptide binding]; other site 1191061005783 inhibitor binding site; inhibition site 1191061005784 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1191061005785 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 1191061005786 Chromate transporter; Region: Chromate_transp; pfam02417 1191061005787 Predicted transcriptional regulators [Transcription]; Region: COG1695 1191061005788 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1191061005789 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1191061005790 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1191061005791 Integrase core domain; Region: rve; pfam00665 1191061005792 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1191061005793 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1191061005794 Integrase core domain; Region: rve; pfam00665 1191061005795 Integrase core domain; Region: rve; pfam00665 1191061005796 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1191061005797 putative mercury resistance protein; Provisional; Region: PRK13747 1191061005798 transcriptional regulator MerD; Provisional; Region: PRK13749 1191061005799 Helix-Turn-Helix DNA binding domain of the MerD transcription regulator; Region: HTH_MerD; cd01111 1191061005800 DNA binding residues [nucleotide binding] 1191061005801 putative dimer interface [polypeptide binding]; other site 1191061005802 putative mercuric reductase; Provisional; Region: PRK13748 1191061005803 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1191061005804 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1191061005805 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1191061005806 putative mercury transport protein MerC; Provisional; Region: PRK13755 1191061005807 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1191061005808 metal-binding site [ion binding] 1191061005809 putative mercuric transport protein; Provisional; Region: PRK13751 1191061005810 putative transcriptional regulator MerR; Provisional; Region: PRK13752 1191061005811 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 1191061005812 DNA binding residues [nucleotide binding] 1191061005813 dimer interface [polypeptide binding]; other site 1191061005814 mercury binding site [ion binding]; other site 1191061005815 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 1191061005816 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1191061005817 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 1191061005818 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 1191061005819 Chloramphenicol acetyltransferase; Region: CAT; cl02008 1191061005820 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1191061005821 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 1191061005822 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 1191061005823 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1191061005824 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1191061005825 Integrase core domain; Region: rve; pfam00665 1191061005826 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1191061005827 Resolvase, N terminal domain; Region: Resolvase; pfam00239 1191061005828 Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796 1191061005829 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1191061005830 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1191061005831 Integrase core domain; Region: rve; pfam00665 1191061005832 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 1191061005833 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1191061005834 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1191061005835 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 1191061005836 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1191061005837 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1191061005838 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1191061005839 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1191061005840 active site 1191061005841 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 1191061005842 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061005843 putative substrate translocation pore; other site 1191061005844 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1191061005845 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1191061005846 active site 1191061005847 motif I; other site 1191061005848 motif II; other site 1191061005849 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1191061005850 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061005851 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1191061005852 putative substrate translocation pore; other site 1191061005853 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1191061005854 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1191061005855 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1191061005856 putative transporter; Provisional; Region: PRK04972 1191061005857 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1191061005858 TrkA-C domain; Region: TrkA_C; pfam02080 1191061005859 TrkA-C domain; Region: TrkA_C; pfam02080 1191061005860 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1191061005861 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 1191061005862 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 1191061005863 GSH binding site [chemical binding]; other site 1191061005864 catalytic residues [active] 1191061005865 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 1191061005866 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1191061005867 dimer interface [polypeptide binding]; other site 1191061005868 FMN binding site [chemical binding]; other site 1191061005869 NADPH bind site [chemical binding]; other site 1191061005870 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 1191061005871 RimK-like ATP-grasp domain; Region: RimK; pfam08443 1191061005872 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1191061005873 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1191061005874 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1191061005875 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 1191061005876 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1191061005877 Walker A/P-loop; other site 1191061005878 ATP binding site [chemical binding]; other site 1191061005879 Q-loop/lid; other site 1191061005880 ABC transporter signature motif; other site 1191061005881 Walker B; other site 1191061005882 D-loop; other site 1191061005883 H-loop/switch region; other site 1191061005884 TOBE domain; Region: TOBE_2; pfam08402 1191061005885 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061005886 dimer interface [polypeptide binding]; other site 1191061005887 conserved gate region; other site 1191061005888 putative PBP binding loops; other site 1191061005889 ABC-ATPase subunit interface; other site 1191061005890 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1191061005891 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061005892 dimer interface [polypeptide binding]; other site 1191061005893 conserved gate region; other site 1191061005894 putative PBP binding loops; other site 1191061005895 ABC-ATPase subunit interface; other site 1191061005896 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 1191061005897 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 1191061005898 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191061005899 S-adenosylmethionine binding site [chemical binding]; other site 1191061005900 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1191061005901 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191061005902 active site 1191061005903 phosphorylation site [posttranslational modification] 1191061005904 intermolecular recognition site; other site 1191061005905 dimerization interface [polypeptide binding]; other site 1191061005906 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1191061005907 DNA binding site [nucleotide binding] 1191061005908 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1191061005909 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191061005910 dimer interface [polypeptide binding]; other site 1191061005911 phosphorylation site [posttranslational modification] 1191061005912 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191061005913 ATP binding site [chemical binding]; other site 1191061005914 Mg2+ binding site [ion binding]; other site 1191061005915 G-X-G motif; other site 1191061005916 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 1191061005917 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1191061005918 substrate binding pocket [chemical binding]; other site 1191061005919 membrane-bound complex binding site; other site 1191061005920 hinge residues; other site 1191061005921 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1191061005922 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061005923 dimer interface [polypeptide binding]; other site 1191061005924 conserved gate region; other site 1191061005925 putative PBP binding loops; other site 1191061005926 ABC-ATPase subunit interface; other site 1191061005927 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1191061005928 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061005929 dimer interface [polypeptide binding]; other site 1191061005930 conserved gate region; other site 1191061005931 putative PBP binding loops; other site 1191061005932 ABC-ATPase subunit interface; other site 1191061005933 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 1191061005934 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1191061005935 substrate binding pocket [chemical binding]; other site 1191061005936 membrane-bound complex binding site; other site 1191061005937 hinge residues; other site 1191061005938 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 1191061005939 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1191061005940 Walker A/P-loop; other site 1191061005941 ATP binding site [chemical binding]; other site 1191061005942 Q-loop/lid; other site 1191061005943 ABC transporter signature motif; other site 1191061005944 Walker B; other site 1191061005945 D-loop; other site 1191061005946 H-loop/switch region; other site 1191061005947 putative lipoprotein; Provisional; Region: PRK10533 1191061005948 hypothetical protein; Provisional; Region: PRK02877 1191061005949 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1191061005950 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1191061005951 amidase catalytic site [active] 1191061005952 Zn binding residues [ion binding]; other site 1191061005953 substrate binding site [chemical binding]; other site 1191061005954 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1191061005955 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1191061005956 NAD(P) binding site [chemical binding]; other site 1191061005957 active site 1191061005958 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1191061005959 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 1191061005960 putative NAD(P) binding site [chemical binding]; other site 1191061005961 putative active site [active] 1191061005962 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1191061005963 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1191061005964 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1191061005965 tetramer interface [polypeptide binding]; other site 1191061005966 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061005967 catalytic residue [active] 1191061005968 pyruvate dehydrogenase; Provisional; Region: PRK09124 1191061005969 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1191061005970 PYR/PP interface [polypeptide binding]; other site 1191061005971 dimer interface [polypeptide binding]; other site 1191061005972 tetramer interface [polypeptide binding]; other site 1191061005973 TPP binding site [chemical binding]; other site 1191061005974 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1191061005975 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1191061005976 TPP-binding site [chemical binding]; other site 1191061005977 Predicted membrane protein [Function unknown]; Region: COG2259 1191061005978 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 1191061005979 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 1191061005980 FAD binding pocket [chemical binding]; other site 1191061005981 FAD binding motif [chemical binding]; other site 1191061005982 phosphate binding motif [ion binding]; other site 1191061005983 beta-alpha-beta structure motif; other site 1191061005984 NAD binding pocket [chemical binding]; other site 1191061005985 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1191061005986 catalytic loop [active] 1191061005987 iron binding site [ion binding]; other site 1191061005988 hybrid cluster protein; Provisional; Region: PRK05290 1191061005989 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1191061005990 ACS interaction site; other site 1191061005991 CODH interaction site; other site 1191061005992 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 1191061005993 hybrid metal cluster; other site 1191061005994 Predicted membrane protein [Function unknown]; Region: COG2431 1191061005995 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1191061005996 amphipathic channel; other site 1191061005997 Asn-Pro-Ala signature motifs; other site 1191061005998 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 1191061005999 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 1191061006000 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1191061006001 putative active site [active] 1191061006002 putative metal-binding site [ion binding]; other site 1191061006003 macrolide transporter subunit MacA; Provisional; Region: PRK11578 1191061006004 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1191061006005 HlyD family secretion protein; Region: HlyD_3; pfam13437 1191061006006 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 1191061006007 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1191061006008 Walker A/P-loop; other site 1191061006009 ATP binding site [chemical binding]; other site 1191061006010 Q-loop/lid; other site 1191061006011 ABC transporter signature motif; other site 1191061006012 Walker B; other site 1191061006013 D-loop; other site 1191061006014 H-loop/switch region; other site 1191061006015 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1191061006016 FtsX-like permease family; Region: FtsX; pfam02687 1191061006017 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1191061006018 DNA-binding site [nucleotide binding]; DNA binding site 1191061006019 RNA-binding motif; other site 1191061006020 Uncharacterized conserved protein [Function unknown]; Region: COG2127 1191061006021 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 1191061006022 Clp amino terminal domain; Region: Clp_N; pfam02861 1191061006023 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191061006024 Walker A motif; other site 1191061006025 ATP binding site [chemical binding]; other site 1191061006026 Walker B motif; other site 1191061006027 arginine finger; other site 1191061006028 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191061006029 Walker A motif; other site 1191061006030 ATP binding site [chemical binding]; other site 1191061006031 Walker B motif; other site 1191061006032 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1191061006033 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1191061006034 rRNA binding site [nucleotide binding]; other site 1191061006035 predicted 30S ribosome binding site; other site 1191061006036 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1191061006037 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 1191061006038 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1191061006039 Walker A/P-loop; other site 1191061006040 ATP binding site [chemical binding]; other site 1191061006041 Q-loop/lid; other site 1191061006042 ABC transporter signature motif; other site 1191061006043 Walker B; other site 1191061006044 D-loop; other site 1191061006045 H-loop/switch region; other site 1191061006046 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 1191061006047 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1191061006048 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1191061006049 Walker A/P-loop; other site 1191061006050 ATP binding site [chemical binding]; other site 1191061006051 Q-loop/lid; other site 1191061006052 ABC transporter signature motif; other site 1191061006053 Walker B; other site 1191061006054 D-loop; other site 1191061006055 H-loop/switch region; other site 1191061006056 thioredoxin reductase; Provisional; Region: PRK10262 1191061006057 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1191061006058 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1191061006059 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 1191061006060 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1191061006061 putative DNA binding site [nucleotide binding]; other site 1191061006062 putative Zn2+ binding site [ion binding]; other site 1191061006063 AsnC family; Region: AsnC_trans_reg; pfam01037 1191061006064 periplasmic chaperone LolA; Region: lolA; TIGR00547 1191061006065 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1191061006066 recombination factor protein RarA; Reviewed; Region: PRK13342 1191061006067 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191061006068 Walker A motif; other site 1191061006069 ATP binding site [chemical binding]; other site 1191061006070 Walker B motif; other site 1191061006071 arginine finger; other site 1191061006072 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1191061006073 seryl-tRNA synthetase; Provisional; Region: PRK05431 1191061006074 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1191061006075 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1191061006076 dimer interface [polypeptide binding]; other site 1191061006077 active site 1191061006078 motif 1; other site 1191061006079 motif 2; other site 1191061006080 motif 3; other site 1191061006081 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 1191061006082 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1191061006083 putative [Fe4-S4] binding site [ion binding]; other site 1191061006084 putative molybdopterin cofactor binding site [chemical binding]; other site 1191061006085 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1191061006086 putative molybdopterin cofactor binding site; other site 1191061006087 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1191061006088 4Fe-4S binding domain; Region: Fer4; pfam00037 1191061006089 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 1191061006090 putative MFS family transporter protein; Provisional; Region: PRK03633 1191061006091 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061006092 putative substrate translocation pore; other site 1191061006093 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1191061006094 active site 1191061006095 phosphorylation site [posttranslational modification] 1191061006096 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1191061006097 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1191061006098 PYR/PP interface [polypeptide binding]; other site 1191061006099 dimer interface [polypeptide binding]; other site 1191061006100 TPP binding site [chemical binding]; other site 1191061006101 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1191061006102 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1191061006103 TPP-binding site [chemical binding]; other site 1191061006104 dimer interface [polypeptide binding]; other site 1191061006105 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 1191061006106 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1191061006107 active site 1191061006108 P-loop; other site 1191061006109 phosphorylation site [posttranslational modification] 1191061006110 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1191061006111 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1191061006112 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1191061006113 putative active site [active] 1191061006114 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 1191061006115 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1191061006116 FeS/SAM binding site; other site 1191061006117 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1191061006118 Pyruvate formate lyase 1; Region: PFL1; cd01678 1191061006119 coenzyme A binding site [chemical binding]; other site 1191061006120 active site 1191061006121 catalytic residues [active] 1191061006122 glycine loop; other site 1191061006123 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 1191061006124 uncharacterized domain; Region: TIGR00702 1191061006125 YcaO-like family; Region: YcaO; pfam02624 1191061006126 Predicted membrane protein [Function unknown]; Region: COG2323 1191061006127 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1191061006128 homodimer interface [polypeptide binding]; other site 1191061006129 substrate-cofactor binding pocket; other site 1191061006130 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061006131 catalytic residue [active] 1191061006132 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1191061006133 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1191061006134 active site 1191061006135 hinge; other site 1191061006136 cytidylate kinase; Provisional; Region: cmk; PRK00023 1191061006137 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1191061006138 CMP-binding site; other site 1191061006139 The sites determining sugar specificity; other site 1191061006140 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1191061006141 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1191061006142 RNA binding site [nucleotide binding]; other site 1191061006143 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1191061006144 RNA binding site [nucleotide binding]; other site 1191061006145 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 1191061006146 RNA binding site [nucleotide binding]; other site 1191061006147 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 1191061006148 RNA binding site [nucleotide binding]; other site 1191061006149 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 1191061006150 RNA binding site [nucleotide binding]; other site 1191061006151 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1191061006152 IHF dimer interface [polypeptide binding]; other site 1191061006153 IHF - DNA interface [nucleotide binding]; other site 1191061006154 ComEC family competence protein; Provisional; Region: PRK11539 1191061006155 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1191061006156 Competence protein; Region: Competence; pfam03772 1191061006157 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1191061006158 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 1191061006159 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1191061006160 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1191061006161 Walker A/P-loop; other site 1191061006162 ATP binding site [chemical binding]; other site 1191061006163 Q-loop/lid; other site 1191061006164 ABC transporter signature motif; other site 1191061006165 Walker B; other site 1191061006166 D-loop; other site 1191061006167 H-loop/switch region; other site 1191061006168 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1191061006169 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 1191061006170 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1191061006171 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1191061006172 Trm112p-like protein; Region: Trm112p; cl01066 1191061006173 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1191061006174 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1191061006175 Ligand binding site; other site 1191061006176 oligomer interface; other site 1191061006177 hypothetical protein; Provisional; Region: PRK10593 1191061006178 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1191061006179 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1191061006180 putative active site [active] 1191061006181 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1191061006182 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191061006183 S-adenosylmethionine binding site [chemical binding]; other site 1191061006184 condesin subunit F; Provisional; Region: PRK05260 1191061006185 condesin subunit E; Provisional; Region: PRK05256 1191061006186 cell division protein MukB; Provisional; Region: mukB; PRK04863 1191061006187 P-loop containing region of AAA domain; Region: AAA_29; cl17516 1191061006188 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1191061006189 murein L,D-transpeptidase; Provisional; Region: PRK10594 1191061006190 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1191061006191 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1191061006192 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1191061006193 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 1191061006194 Peptidase M15; Region: Peptidase_M15_3; cl01194 1191061006195 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1191061006196 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1191061006197 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1191061006198 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1191061006199 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061006200 homodimer interface [polypeptide binding]; other site 1191061006201 catalytic residue [active] 1191061006202 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1191061006203 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1191061006204 eyelet of channel; other site 1191061006205 trimer interface [polypeptide binding]; other site 1191061006206 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1191061006207 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1191061006208 putative dimer interface [polypeptide binding]; other site 1191061006209 putative anticodon binding site; other site 1191061006210 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1191061006211 homodimer interface [polypeptide binding]; other site 1191061006212 motif 1; other site 1191061006213 motif 2; other site 1191061006214 active site 1191061006215 motif 3; other site 1191061006216 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 1191061006217 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 1191061006218 active site 1191061006219 aminopeptidase N; Provisional; Region: pepN; PRK14015 1191061006220 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 1191061006221 active site 1191061006222 Zn binding site [ion binding]; other site 1191061006223 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 1191061006224 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1191061006225 Walker A/P-loop; other site 1191061006226 ATP binding site [chemical binding]; other site 1191061006227 Q-loop/lid; other site 1191061006228 ABC transporter signature motif; other site 1191061006229 Walker B; other site 1191061006230 D-loop; other site 1191061006231 H-loop/switch region; other site 1191061006232 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1191061006233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061006234 dimer interface [polypeptide binding]; other site 1191061006235 conserved gate region; other site 1191061006236 putative PBP binding loops; other site 1191061006237 ABC-ATPase subunit interface; other site 1191061006238 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 1191061006239 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1191061006240 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1191061006241 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1191061006242 quinone interaction residues [chemical binding]; other site 1191061006243 active site 1191061006244 catalytic residues [active] 1191061006245 FMN binding site [chemical binding]; other site 1191061006246 substrate binding site [chemical binding]; other site 1191061006247 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 1191061006248 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1191061006249 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1191061006250 MOSC domain; Region: MOSC; pfam03473 1191061006251 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1191061006252 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1191061006253 catalytic loop [active] 1191061006254 iron binding site [ion binding]; other site 1191061006255 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 1191061006256 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1191061006257 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191061006258 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1191061006259 putative RNA binding site [nucleotide binding]; other site 1191061006260 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191061006261 S-adenosylmethionine binding site [chemical binding]; other site 1191061006262 ABC transporter ATPase component; Reviewed; Region: PRK11147 1191061006263 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1191061006264 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1191061006265 Walker A/P-loop; other site 1191061006266 Walker A/P-loop; other site 1191061006267 ATP binding site [chemical binding]; other site 1191061006268 ATP binding site [chemical binding]; other site 1191061006269 Q-loop/lid; other site 1191061006270 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1191061006271 ABC transporter signature motif; other site 1191061006272 Walker B; other site 1191061006273 D-loop; other site 1191061006274 ABC transporter; Region: ABC_tran_2; pfam12848 1191061006275 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1191061006276 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 1191061006277 Paraquat-inducible protein A; Region: PqiA; pfam04403 1191061006278 Paraquat-inducible protein A; Region: PqiA; pfam04403 1191061006279 paraquat-inducible protein B; Provisional; Region: PRK10807 1191061006280 mce related protein; Region: MCE; pfam02470 1191061006281 mce related protein; Region: MCE; pfam02470 1191061006282 mce related protein; Region: MCE; pfam02470 1191061006283 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 1191061006284 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1191061006285 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 1191061006286 active site 1 [active] 1191061006287 dimer interface [polypeptide binding]; other site 1191061006288 active site 2 [active] 1191061006289 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 1191061006290 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1191061006291 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 1191061006292 outer membrane protein A; Reviewed; Region: PRK10808 1191061006293 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 1191061006294 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1191061006295 ligand binding site [chemical binding]; other site 1191061006296 Cell division inhibitor SulA; Region: SulA; cl01880 1191061006297 TfoX N-terminal domain; Region: TfoX_N; pfam04993 1191061006298 TfoX C-terminal domain; Region: TfoX_C; pfam04994 1191061006299 TIGR01666 family membrane protein; Region: YCCS 1191061006300 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1191061006301 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1191061006302 Predicted membrane protein [Function unknown]; Region: COG3304 1191061006303 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1191061006304 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1191061006305 DNA helicase IV; Provisional; Region: helD; PRK11054 1191061006306 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 1191061006307 Part of AAA domain; Region: AAA_19; pfam13245 1191061006308 Family description; Region: UvrD_C_2; pfam13538 1191061006309 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1191061006310 active site 1191061006311 dimer interfaces [polypeptide binding]; other site 1191061006312 catalytic residues [active] 1191061006313 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1191061006314 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 1191061006315 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 1191061006316 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1191061006317 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1191061006318 Walker A/P-loop; other site 1191061006319 ATP binding site [chemical binding]; other site 1191061006320 Q-loop/lid; other site 1191061006321 ABC transporter signature motif; other site 1191061006322 Walker B; other site 1191061006323 D-loop; other site 1191061006324 H-loop/switch region; other site 1191061006325 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1191061006326 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1191061006327 HlyD family secretion protein; Region: HlyD_3; pfam13437 1191061006328 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 1191061006329 heat shock protein HspQ; Provisional; Region: PRK14129 1191061006330 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 1191061006331 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 1191061006332 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1191061006333 putative RNA binding site [nucleotide binding]; other site 1191061006334 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191061006335 S-adenosylmethionine binding site [chemical binding]; other site 1191061006336 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1191061006337 substrate binding site [chemical binding]; other site 1191061006338 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1191061006339 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061006340 acylphosphatase; Provisional; Region: PRK14426 1191061006341 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 1191061006342 sulfur transfer protein TusE; Provisional; Region: PRK11508 1191061006343 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1191061006344 YccA-like proteins; Region: YccA_like; cd10433 1191061006345 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1191061006346 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1191061006347 peptide binding site [polypeptide binding]; other site 1191061006348 outer membrane porin, OprD family; Region: OprD; pfam03573 1191061006349 hypothetical protein; Provisional; Region: PRK02947 1191061006350 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1191061006351 putative active site [active] 1191061006352 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 1191061006353 hypothetical protein; Provisional; Region: PRK02947 1191061006354 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1191061006355 putative active site [active] 1191061006356 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1191061006357 active site 1191061006358 phosphorylation site [posttranslational modification] 1191061006359 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 1191061006360 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 1191061006361 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1191061006362 active pocket/dimerization site; other site 1191061006363 active site 1191061006364 phosphorylation site [posttranslational modification] 1191061006365 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1191061006366 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1191061006367 DNA-binding site [nucleotide binding]; DNA binding site 1191061006368 UTRA domain; Region: UTRA; pfam07702 1191061006369 aspartate aminotransferase; Provisional; Region: PRK05764 1191061006370 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1191061006371 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061006372 homodimer interface [polypeptide binding]; other site 1191061006373 catalytic residue [active] 1191061006374 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1191061006375 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1191061006376 conserved cys residue [active] 1191061006377 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1191061006378 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1191061006379 inhibitor site; inhibition site 1191061006380 active site 1191061006381 dimer interface [polypeptide binding]; other site 1191061006382 catalytic residue [active] 1191061006383 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1191061006384 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1191061006385 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1191061006386 active site 1191061006387 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1191061006388 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1191061006389 metal binding site [ion binding]; metal-binding site 1191061006390 substrate binding pocket [chemical binding]; other site 1191061006391 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 1191061006392 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 1191061006393 metal binding site [ion binding]; metal-binding site 1191061006394 dimer interface [polypeptide binding]; other site 1191061006395 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1191061006396 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1191061006397 Walker A/P-loop; other site 1191061006398 ATP binding site [chemical binding]; other site 1191061006399 Q-loop/lid; other site 1191061006400 ABC transporter signature motif; other site 1191061006401 Walker B; other site 1191061006402 D-loop; other site 1191061006403 H-loop/switch region; other site 1191061006404 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061006405 dimer interface [polypeptide binding]; other site 1191061006406 conserved gate region; other site 1191061006407 putative PBP binding loops; other site 1191061006408 ABC-ATPase subunit interface; other site 1191061006409 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1191061006410 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1191061006411 substrate binding pocket [chemical binding]; other site 1191061006412 membrane-bound complex binding site; other site 1191061006413 hinge residues; other site 1191061006414 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1191061006415 DNA-binding site [nucleotide binding]; DNA binding site 1191061006416 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1191061006417 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1191061006418 FCD domain; Region: FCD; pfam07729 1191061006419 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1191061006420 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1191061006421 putative NAD(P) binding site [chemical binding]; other site 1191061006422 putative active site [active] 1191061006423 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061006424 putative substrate translocation pore; other site 1191061006425 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1191061006426 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061006427 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1191061006428 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061006429 alpha-galactosidase; Provisional; Region: PRK15076 1191061006430 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1191061006431 NAD binding site [chemical binding]; other site 1191061006432 sugar binding site [chemical binding]; other site 1191061006433 divalent metal binding site [ion binding]; other site 1191061006434 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1191061006435 dimer interface [polypeptide binding]; other site 1191061006436 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1191061006437 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1191061006438 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061006439 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061006440 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1191061006441 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1191061006442 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1191061006443 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1191061006444 putative NAD(P) binding site [chemical binding]; other site 1191061006445 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1191061006446 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1191061006447 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1191061006448 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1191061006449 HlyD family secretion protein; Region: HlyD_3; pfam13437 1191061006450 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1191061006451 hypothetical protein; Provisional; Region: PRK07505 1191061006452 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1191061006453 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1191061006454 catalytic residue [active] 1191061006455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061006456 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1191061006457 putative substrate translocation pore; other site 1191061006458 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1191061006459 EamA-like transporter family; Region: EamA; cl17759 1191061006460 EamA-like transporter family; Region: EamA; pfam00892 1191061006461 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1191061006462 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1191061006463 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1191061006464 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 1191061006465 homodimer interface [polypeptide binding]; other site 1191061006466 substrate-cofactor binding pocket; other site 1191061006467 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061006468 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1191061006469 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1191061006470 Walker A/P-loop; other site 1191061006471 ATP binding site [chemical binding]; other site 1191061006472 Q-loop/lid; other site 1191061006473 ABC transporter signature motif; other site 1191061006474 Walker B; other site 1191061006475 D-loop; other site 1191061006476 H-loop/switch region; other site 1191061006477 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1191061006478 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061006479 dimer interface [polypeptide binding]; other site 1191061006480 conserved gate region; other site 1191061006481 putative PBP binding loops; other site 1191061006482 ABC-ATPase subunit interface; other site 1191061006483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061006484 dimer interface [polypeptide binding]; other site 1191061006485 conserved gate region; other site 1191061006486 ABC-ATPase subunit interface; other site 1191061006487 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1191061006488 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1191061006489 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1191061006490 substrate binding pocket [chemical binding]; other site 1191061006491 membrane-bound complex binding site; other site 1191061006492 hinge residues; other site 1191061006493 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061006494 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061006495 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1191061006496 putative dimerization interface [polypeptide binding]; other site 1191061006497 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 1191061006498 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061006499 putative substrate translocation pore; other site 1191061006500 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1191061006501 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1191061006502 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1191061006503 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 1191061006504 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1191061006505 active site 1191061006506 nucleotide binding site [chemical binding]; other site 1191061006507 HIGH motif; other site 1191061006508 KMSKS motif; other site 1191061006509 citrate lyase subunit gamma; Provisional; Region: PRK13253 1191061006510 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1191061006511 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 1191061006512 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802 1191061006513 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 1191061006514 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 1191061006515 Serine hydrolase; Region: Ser_hydrolase; pfam06821 1191061006516 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1191061006517 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 1191061006518 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 1191061006519 substrate binding site [chemical binding]; other site 1191061006520 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 1191061006521 substrate binding site [chemical binding]; other site 1191061006522 ligand binding site [chemical binding]; other site 1191061006523 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1191061006524 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1191061006525 transmembrane helices; other site 1191061006526 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1191061006527 DNA-binding site [nucleotide binding]; DNA binding site 1191061006528 RNA-binding motif; other site 1191061006529 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1191061006530 DNA-binding site [nucleotide binding]; DNA binding site 1191061006531 RNA-binding motif; other site 1191061006532 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1191061006533 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1191061006534 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191061006535 active site 1191061006536 phosphorylation site [posttranslational modification] 1191061006537 intermolecular recognition site; other site 1191061006538 dimerization interface [polypeptide binding]; other site 1191061006539 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1191061006540 DNA binding site [nucleotide binding] 1191061006541 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1191061006542 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1191061006543 dimerization interface [polypeptide binding]; other site 1191061006544 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191061006545 dimer interface [polypeptide binding]; other site 1191061006546 phosphorylation site [posttranslational modification] 1191061006547 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191061006548 ATP binding site [chemical binding]; other site 1191061006549 Mg2+ binding site [ion binding]; other site 1191061006550 G-X-G motif; other site 1191061006551 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 1191061006552 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1191061006553 homotrimer interaction site [polypeptide binding]; other site 1191061006554 putative active site [active] 1191061006555 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1191061006556 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1191061006557 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1191061006558 putative active site pocket [active] 1191061006559 dimerization interface [polypeptide binding]; other site 1191061006560 putative catalytic residue [active] 1191061006561 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 1191061006562 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1191061006563 dimerization domain [polypeptide binding]; other site 1191061006564 dimer interface [polypeptide binding]; other site 1191061006565 catalytic residues [active] 1191061006566 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1191061006567 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 1191061006568 catalytic residues [active] 1191061006569 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 1191061006570 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 1191061006571 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1191061006572 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1191061006573 DsbD alpha interface [polypeptide binding]; other site 1191061006574 catalytic residues [active] 1191061006575 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 1191061006576 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061006577 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 1191061006578 putative substrate binding pocket [chemical binding]; other site 1191061006579 putative dimerization interface [polypeptide binding]; other site 1191061006580 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 1191061006581 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1191061006582 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1191061006583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061006584 dimer interface [polypeptide binding]; other site 1191061006585 conserved gate region; other site 1191061006586 ABC-ATPase subunit interface; other site 1191061006587 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061006588 dimer interface [polypeptide binding]; other site 1191061006589 conserved gate region; other site 1191061006590 putative PBP binding loops; other site 1191061006591 ABC-ATPase subunit interface; other site 1191061006592 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1191061006593 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1191061006594 Walker A/P-loop; other site 1191061006595 ATP binding site [chemical binding]; other site 1191061006596 Q-loop/lid; other site 1191061006597 ABC transporter signature motif; other site 1191061006598 Walker B; other site 1191061006599 D-loop; other site 1191061006600 H-loop/switch region; other site 1191061006601 TOBE domain; Region: TOBE_2; pfam08402 1191061006602 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1191061006603 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1191061006604 FMN-binding pocket [chemical binding]; other site 1191061006605 flavin binding motif; other site 1191061006606 phosphate binding motif [ion binding]; other site 1191061006607 beta-alpha-beta structure motif; other site 1191061006608 NAD binding pocket [chemical binding]; other site 1191061006609 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1191061006610 catalytic loop [active] 1191061006611 iron binding site [ion binding]; other site 1191061006612 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1191061006613 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1191061006614 [2Fe-2S] cluster binding site [ion binding]; other site 1191061006615 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1191061006616 hydrophobic ligand binding site; other site 1191061006617 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061006618 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061006619 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1191061006620 dimerization interface [polypeptide binding]; other site 1191061006621 FAD binding domain; Region: FAD_binding_3; pfam01494 1191061006622 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1191061006623 xanthine permease; Region: pbuX; TIGR03173 1191061006624 OHCU decarboxylase; Region: UraD_2; TIGR03180 1191061006625 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1191061006626 active site 1191061006627 homotetramer interface [polypeptide binding]; other site 1191061006628 guanine deaminase; Provisional; Region: PRK09228 1191061006629 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 1191061006630 active site 1191061006631 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 1191061006632 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1191061006633 Na binding site [ion binding]; other site 1191061006634 putative substrate binding site [chemical binding]; other site 1191061006635 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1191061006636 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1191061006637 DNA-binding site [nucleotide binding]; DNA binding site 1191061006638 FCD domain; Region: FCD; pfam07729 1191061006639 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 1191061006640 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 1191061006641 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 1191061006642 active site 1191061006643 catalytic site [active] 1191061006644 tetramer interface [polypeptide binding]; other site 1191061006645 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 1191061006646 amidase; Provisional; Region: PRK09201 1191061006647 Amidase; Region: Amidase; pfam01425 1191061006648 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 1191061006649 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1191061006650 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1191061006651 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1191061006652 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1191061006653 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1191061006654 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1191061006655 substrate binding pocket [chemical binding]; other site 1191061006656 membrane-bound complex binding site; other site 1191061006657 hinge residues; other site 1191061006658 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1191061006659 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061006660 dimer interface [polypeptide binding]; other site 1191061006661 conserved gate region; other site 1191061006662 putative PBP binding loops; other site 1191061006663 ABC-ATPase subunit interface; other site 1191061006664 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1191061006665 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061006666 ABC-ATPase subunit interface; other site 1191061006667 putative PBP binding loops; other site 1191061006668 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1191061006669 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1191061006670 Walker A/P-loop; other site 1191061006671 ATP binding site [chemical binding]; other site 1191061006672 Q-loop/lid; other site 1191061006673 ABC transporter signature motif; other site 1191061006674 Walker B; other site 1191061006675 D-loop; other site 1191061006676 H-loop/switch region; other site 1191061006677 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1191061006678 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1191061006679 catalytic residue [active] 1191061006680 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1191061006681 allantoate amidohydrolase; Reviewed; Region: PRK09290 1191061006682 active site 1191061006683 metal binding site [ion binding]; metal-binding site 1191061006684 dimer interface [polypeptide binding]; other site 1191061006685 Periplasmic pectate lyase; Region: Pectate_lyase_2; pfam06917 1191061006686 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 1191061006687 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1191061006688 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1191061006689 DNA binding residues [nucleotide binding] 1191061006690 dimerization interface [polypeptide binding]; other site 1191061006691 Chorismate mutase type II; Region: CM_2; smart00830 1191061006692 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1191061006693 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1191061006694 metal binding site [ion binding]; metal-binding site 1191061006695 active site 1191061006696 I-site; other site 1191061006697 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1191061006698 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061006699 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1191061006700 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1191061006701 active site 1191061006702 P-loop; other site 1191061006703 phosphorylation site [posttranslational modification] 1191061006704 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 1191061006705 FeS/SAM binding site; other site 1191061006706 pyruvate formate lyase II activase; Provisional; Region: PRK10076 1191061006707 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 1191061006708 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 1191061006709 dimer interface [polypeptide binding]; other site 1191061006710 active site 1191061006711 glycine loop; other site 1191061006712 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1191061006713 active site 1191061006714 P-loop; other site 1191061006715 phosphorylation site [posttranslational modification] 1191061006716 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 1191061006717 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1191061006718 dimerization domain swap beta strand [polypeptide binding]; other site 1191061006719 regulatory protein interface [polypeptide binding]; other site 1191061006720 active site 1191061006721 regulatory phosphorylation site [posttranslational modification]; other site 1191061006722 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1191061006723 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1191061006724 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1191061006725 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1191061006726 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1191061006727 active site 1191061006728 phosphorylation site [posttranslational modification] 1191061006729 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1191061006730 tartrate dehydrogenase; Region: TTC; TIGR02089 1191061006731 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1191061006732 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1191061006733 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 1191061006734 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 1191061006735 NAD(P) binding site [chemical binding]; other site 1191061006736 catalytic residues [active] 1191061006737 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1191061006738 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1191061006739 non-specific DNA binding site [nucleotide binding]; other site 1191061006740 salt bridge; other site 1191061006741 sequence-specific DNA binding site [nucleotide binding]; other site 1191061006742 Cupin domain; Region: Cupin_2; pfam07883 1191061006743 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 1191061006744 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1191061006745 catalytic triad [active] 1191061006746 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1191061006747 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1191061006748 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1191061006749 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 1191061006750 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1191061006751 catalytic core [active] 1191061006752 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1191061006753 hypothetical protein; Provisional; Region: PRK10174 1191061006754 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 1191061006755 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1191061006756 General stress protein [General function prediction only]; Region: GsiB; COG3729 1191061006757 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1191061006758 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 1191061006759 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 1191061006760 putative FMN binding site [chemical binding]; other site 1191061006761 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1191061006762 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1191061006763 homotrimer interaction site [polypeptide binding]; other site 1191061006764 putative active site [active] 1191061006765 Isochorismatase family; Region: Isochorismatase; pfam00857 1191061006766 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1191061006767 catalytic triad [active] 1191061006768 conserved cis-peptide bond; other site 1191061006769 pyrimidine utilization protein A; Region: RutA; TIGR03612 1191061006770 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1191061006771 active site 1191061006772 dimer interface [polypeptide binding]; other site 1191061006773 non-prolyl cis peptide bond; other site 1191061006774 insertion regions; other site 1191061006775 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1191061006776 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 1191061006777 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1191061006778 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1191061006779 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 1191061006780 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 1191061006781 Predicted transcriptional regulator [Transcription]; Region: COG3905 1191061006782 Proline dehydrogenase; Region: Pro_dh; pfam01619 1191061006783 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1191061006784 Glutamate binding site [chemical binding]; other site 1191061006785 NAD binding site [chemical binding]; other site 1191061006786 catalytic residues [active] 1191061006787 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1191061006788 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1191061006789 Na binding site [ion binding]; other site 1191061006790 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 1191061006791 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1191061006792 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1191061006793 Nucleoside recognition; Region: Gate; pfam07670 1191061006794 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1191061006795 FTR1 family protein; Region: TIGR00145 1191061006796 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 1191061006797 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1191061006798 Imelysin; Region: Peptidase_M75; pfam09375 1191061006799 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1191061006800 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1191061006801 hypothetical protein; Provisional; Region: PRK10536 1191061006802 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1191061006803 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350 1191061006804 MltA-interacting protein MipA; Region: MipA; cl01504 1191061006805 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1191061006806 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191061006807 active site 1191061006808 phosphorylation site [posttranslational modification] 1191061006809 intermolecular recognition site; other site 1191061006810 dimerization interface [polypeptide binding]; other site 1191061006811 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1191061006812 DNA binding site [nucleotide binding] 1191061006813 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1191061006814 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191061006815 dimer interface [polypeptide binding]; other site 1191061006816 phosphorylation site [posttranslational modification] 1191061006817 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191061006818 ATP binding site [chemical binding]; other site 1191061006819 Mg2+ binding site [ion binding]; other site 1191061006820 G-X-G motif; other site 1191061006821 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1191061006822 HlyD family secretion protein; Region: HlyD_3; pfam13437 1191061006823 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1191061006824 Isochorismatase family; Region: Isochorismatase; pfam00857 1191061006825 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1191061006826 catalytic triad [active] 1191061006827 dimer interface [polypeptide binding]; other site 1191061006828 conserved cis-peptide bond; other site 1191061006829 Pirin-related protein [General function prediction only]; Region: COG1741 1191061006830 Pirin; Region: Pirin; pfam02678 1191061006831 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1191061006832 LysR family transcriptional regulator; Provisional; Region: PRK14997 1191061006833 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061006834 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 1191061006835 putative effector binding pocket; other site 1191061006836 putative dimerization interface [polypeptide binding]; other site 1191061006837 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 1191061006838 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 1191061006839 putative ligand binding site [chemical binding]; other site 1191061006840 NAD binding site [chemical binding]; other site 1191061006841 dimerization interface [polypeptide binding]; other site 1191061006842 catalytic site [active] 1191061006843 putative hydrolase; Validated; Region: PRK09248 1191061006844 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 1191061006845 active site 1191061006846 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 1191061006847 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 1191061006848 Fimbrial protein; Region: Fimbrial; cl01416 1191061006849 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1191061006850 putative ADP-ribose binding site [chemical binding]; other site 1191061006851 putative active site [active] 1191061006852 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1191061006853 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1191061006854 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 1191061006855 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1191061006856 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 1191061006857 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 1191061006858 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1191061006859 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 1191061006860 Ligand binding site; other site 1191061006861 DXD motif; other site 1191061006862 lipoprotein; Provisional; Region: PRK10175 1191061006863 secY/secA suppressor protein; Provisional; Region: PRK11467 1191061006864 drug efflux system protein MdtG; Provisional; Region: PRK09874 1191061006865 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061006866 putative substrate translocation pore; other site 1191061006867 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1191061006868 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1191061006869 putative acyl-acceptor binding pocket; other site 1191061006870 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1191061006871 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1191061006872 active site residue [active] 1191061006873 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 1191061006874 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1191061006875 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 1191061006876 DNA damage-inducible protein I; Provisional; Region: PRK10597 1191061006877 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 1191061006878 active site 1191061006879 substrate binding pocket [chemical binding]; other site 1191061006880 dimer interface [polypeptide binding]; other site 1191061006881 lipoprotein; Provisional; Region: PRK10598 1191061006882 glutaredoxin 2; Provisional; Region: PRK10387 1191061006883 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 1191061006884 C-terminal domain interface [polypeptide binding]; other site 1191061006885 GSH binding site (G-site) [chemical binding]; other site 1191061006886 catalytic residues [active] 1191061006887 putative dimer interface [polypeptide binding]; other site 1191061006888 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 1191061006889 N-terminal domain interface [polypeptide binding]; other site 1191061006890 multidrug resistance protein MdtH; Provisional; Region: PRK11646 1191061006891 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061006892 putative substrate translocation pore; other site 1191061006893 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 1191061006894 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1191061006895 hypothetical protein; Provisional; Region: PRK11239 1191061006896 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 1191061006897 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1191061006898 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1191061006899 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1191061006900 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1191061006901 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1191061006902 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061006903 putative substrate translocation pore; other site 1191061006904 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061006905 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061006906 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1191061006907 putative effector binding pocket; other site 1191061006908 dimerization interface [polypeptide binding]; other site 1191061006909 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1191061006910 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1191061006911 homodimer interface [polypeptide binding]; other site 1191061006912 oligonucleotide binding site [chemical binding]; other site 1191061006913 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 1191061006914 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 1191061006915 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1191061006916 RNA binding surface [nucleotide binding]; other site 1191061006917 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1191061006918 active site 1191061006919 Abhydrolase family; Region: Abhydrolase_7; pfam12715 1191061006920 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1191061006921 Maf-like protein; Region: Maf; pfam02545 1191061006922 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1191061006923 active site 1191061006924 dimer interface [polypeptide binding]; other site 1191061006925 hypothetical protein; Provisional; Region: PRK11193 1191061006926 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1191061006927 putative phosphate acyltransferase; Provisional; Region: PRK05331 1191061006928 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1191061006929 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1191061006930 dimer interface [polypeptide binding]; other site 1191061006931 active site 1191061006932 CoA binding pocket [chemical binding]; other site 1191061006933 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1191061006934 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1191061006935 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1191061006936 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1191061006937 NAD(P) binding site [chemical binding]; other site 1191061006938 homotetramer interface [polypeptide binding]; other site 1191061006939 homodimer interface [polypeptide binding]; other site 1191061006940 active site 1191061006941 acyl carrier protein; Provisional; Region: acpP; PRK00982 1191061006942 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1191061006943 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1191061006944 dimer interface [polypeptide binding]; other site 1191061006945 active site 1191061006946 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1191061006947 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1191061006948 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061006949 catalytic residue [active] 1191061006950 conserved hypothetical protein, YceG family; Region: TIGR00247 1191061006951 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1191061006952 dimerization interface [polypeptide binding]; other site 1191061006953 thymidylate kinase; Validated; Region: tmk; PRK00698 1191061006954 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1191061006955 TMP-binding site; other site 1191061006956 ATP-binding site [chemical binding]; other site 1191061006957 DNA polymerase III subunit delta'; Validated; Region: PRK07993 1191061006958 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1191061006959 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 1191061006960 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1191061006961 active site 1191061006962 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 1191061006963 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1191061006964 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1191061006965 active site turn [active] 1191061006966 phosphorylation site [posttranslational modification] 1191061006967 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 1191061006968 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1191061006969 N-terminal plug; other site 1191061006970 ligand-binding site [chemical binding]; other site 1191061006971 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1191061006972 nucleotide binding site/active site [active] 1191061006973 HIT family signature motif; other site 1191061006974 catalytic residue [active] 1191061006975 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 1191061006976 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 1191061006977 putative dimer interface [polypeptide binding]; other site 1191061006978 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 1191061006979 thiamine kinase; Region: ycfN_thiK; TIGR02721 1191061006980 active site 1191061006981 substrate binding site [chemical binding]; other site 1191061006982 ATP binding site [chemical binding]; other site 1191061006983 thiamine kinase; Provisional; Region: thiK; PRK10271 1191061006984 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1191061006985 beta-hexosaminidase; Provisional; Region: PRK05337 1191061006986 hypothetical protein; Provisional; Region: PRK04940 1191061006987 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1191061006988 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1191061006989 hypothetical protein; Provisional; Region: PRK11280 1191061006990 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1191061006991 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1191061006992 N-terminal plug; other site 1191061006993 ligand-binding site [chemical binding]; other site 1191061006994 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1191061006995 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1191061006996 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1191061006997 L,D-transpeptidase; Provisional; Region: PRK10190 1191061006998 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1191061006999 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1191061007000 transcription-repair coupling factor; Provisional; Region: PRK10689 1191061007001 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1191061007002 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1191061007003 ATP binding site [chemical binding]; other site 1191061007004 putative Mg++ binding site [ion binding]; other site 1191061007005 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1191061007006 nucleotide binding region [chemical binding]; other site 1191061007007 ATP-binding site [chemical binding]; other site 1191061007008 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1191061007009 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 1191061007010 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1191061007011 FtsX-like permease family; Region: FtsX; pfam02687 1191061007012 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 1191061007013 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1191061007014 Walker A/P-loop; other site 1191061007015 ATP binding site [chemical binding]; other site 1191061007016 Q-loop/lid; other site 1191061007017 ABC transporter signature motif; other site 1191061007018 Walker B; other site 1191061007019 D-loop; other site 1191061007020 H-loop/switch region; other site 1191061007021 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 1191061007022 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1191061007023 FtsX-like permease family; Region: FtsX; pfam02687 1191061007024 fructokinase; Reviewed; Region: PRK09557 1191061007025 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1191061007026 nucleotide binding site [chemical binding]; other site 1191061007027 NAD-dependent deacetylase; Provisional; Region: PRK00481 1191061007028 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1191061007029 NAD+ binding site [chemical binding]; other site 1191061007030 substrate binding site [chemical binding]; other site 1191061007031 Zn binding site [ion binding]; other site 1191061007032 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1191061007033 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1191061007034 DNA binding residues [nucleotide binding] 1191061007035 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1191061007036 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1191061007037 substrate binding site [chemical binding]; other site 1191061007038 dimer interface [polypeptide binding]; other site 1191061007039 triosephosphate isomerase; Provisional; Region: PRK14565 1191061007040 catalytic triad [active] 1191061007041 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1191061007042 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 1191061007043 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 1191061007044 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 1191061007045 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1191061007046 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 1191061007047 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 1191061007048 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1191061007049 transaldolase-like protein; Provisional; Region: PTZ00411 1191061007050 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1191061007051 active site 1191061007052 dimer interface [polypeptide binding]; other site 1191061007053 catalytic residue [active] 1191061007054 transketolase; Reviewed; Region: PRK12753 1191061007055 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1191061007056 TPP-binding site [chemical binding]; other site 1191061007057 dimer interface [polypeptide binding]; other site 1191061007058 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1191061007059 PYR/PP interface [polypeptide binding]; other site 1191061007060 dimer interface [polypeptide binding]; other site 1191061007061 TPP binding site [chemical binding]; other site 1191061007062 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1191061007063 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 1191061007064 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1191061007065 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1191061007066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061007067 dimer interface [polypeptide binding]; other site 1191061007068 conserved gate region; other site 1191061007069 putative PBP binding loops; other site 1191061007070 ABC-ATPase subunit interface; other site 1191061007071 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 1191061007072 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1191061007073 Walker A/P-loop; other site 1191061007074 ATP binding site [chemical binding]; other site 1191061007075 Q-loop/lid; other site 1191061007076 ABC transporter signature motif; other site 1191061007077 Walker B; other site 1191061007078 D-loop; other site 1191061007079 H-loop/switch region; other site 1191061007080 TOBE domain; Region: TOBE_2; pfam08402 1191061007081 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 1191061007082 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1191061007083 metal binding site [ion binding]; metal-binding site 1191061007084 dimer interface [polypeptide binding]; other site 1191061007085 Uncharacterized conserved protein [Function unknown]; Region: COG2850 1191061007086 sensor protein PhoQ; Provisional; Region: PRK10815 1191061007087 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 1191061007088 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 1191061007089 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191061007090 ATP binding site [chemical binding]; other site 1191061007091 Mg2+ binding site [ion binding]; other site 1191061007092 G-X-G motif; other site 1191061007093 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 1191061007094 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191061007095 active site 1191061007096 phosphorylation site [posttranslational modification] 1191061007097 intermolecular recognition site; other site 1191061007098 dimerization interface [polypeptide binding]; other site 1191061007099 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1191061007100 DNA binding site [nucleotide binding] 1191061007101 Predicted transcriptional regulators [Transcription]; Region: COG1733 1191061007102 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1191061007103 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1191061007104 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061007105 putative substrate translocation pore; other site 1191061007106 adenylosuccinate lyase; Provisional; Region: PRK09285 1191061007107 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1191061007108 tetramer interface [polypeptide binding]; other site 1191061007109 active site 1191061007110 putative lysogenization regulator; Reviewed; Region: PRK00218 1191061007111 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1191061007112 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 1191061007113 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 1191061007114 nudix motif; other site 1191061007115 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 1191061007116 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 1191061007117 probable active site [active] 1191061007118 isocitrate dehydrogenase; Validated; Region: PRK07362 1191061007119 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1191061007120 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 1191061007121 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1191061007122 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 1191061007123 dimer interface [polypeptide binding]; other site 1191061007124 active site 1191061007125 Int/Topo IB signature motif; other site 1191061007126 PRTRC system ParB family protein; Region: PRTRC_parB; TIGR03734 1191061007127 HD domain; Region: HD_3; cl17350 1191061007128 Uncharacterized conserved protein (DUF2303); Region: DUF2303; pfam10065 1191061007129 threonine dehydratase; Validated; Region: PRK08639 1191061007130 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1191061007131 Catalytic site [active] 1191061007132 Helix-turn-helix domain; Region: HTH_36; pfam13730 1191061007133 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524 1191061007134 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869 1191061007135 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1191061007136 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1191061007137 cofactor binding site; other site 1191061007138 DNA binding site [nucleotide binding] 1191061007139 substrate interaction site [chemical binding]; other site 1191061007140 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1191061007141 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1191061007142 KilA-N domain; Region: KilA-N; pfam04383 1191061007143 Protein of unknown function (DUF968); Region: DUF968; pfam06147 1191061007144 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191061007145 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1191061007146 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1191061007147 DNA methylase; Region: N6_N4_Mtase; pfam01555 1191061007148 Protein of unknown function (DUF754); Region: DUF754; pfam05449 1191061007149 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 1191061007150 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 1191061007151 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 1191061007152 Protein of unknown function (DUF2560); Region: DUF2560; cl10280 1191061007153 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1191061007154 active site 1191061007155 Phage terminase, small subunit; Region: Terminase_4; pfam05119 1191061007156 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1191061007157 Phage-related protein [Function unknown]; Region: COG4695 1191061007158 Phage portal protein; Region: Phage_portal; pfam04860 1191061007159 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 1191061007160 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1191061007161 Phage capsid family; Region: Phage_capsid; pfam05065 1191061007162 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 1191061007163 oligomerization interface [polypeptide binding]; other site 1191061007164 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 1191061007165 Immunoglobulin domain; Region: Ig; cl11960 1191061007166 Phage tail assembly chaperone; Region: Phage_TAC; pfam06222 1191061007167 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 1191061007168 Phage-related minor tail protein [Function unknown]; Region: COG5281 1191061007169 tape measure domain; Region: tape_meas_nterm; TIGR02675 1191061007170 Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120 1191061007171 phage tail tape measure protein, lambda family; Region: tape_meas_lam_C; TIGR01541 1191061007172 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 1191061007173 Domain of unknown function (DUF1833); Region: DUF1833; pfam08875 1191061007174 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945 1191061007175 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1191061007176 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1191061007177 catalytic residues [active] 1191061007178 catalytic nucleophile [active] 1191061007179 Presynaptic Site I dimer interface [polypeptide binding]; other site 1191061007180 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1191061007181 Synaptic Flat tetramer interface [polypeptide binding]; other site 1191061007182 Synaptic Site I dimer interface [polypeptide binding]; other site 1191061007183 DNA binding site [nucleotide binding] 1191061007184 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1191061007185 DNA-binding interface [nucleotide binding]; DNA binding site 1191061007186 DinI-like family; Region: DinI; cl11630 1191061007187 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1191061007188 Catalytic site [active] 1191061007189 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 1191061007190 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1191061007191 active site 1191061007192 DNA binding site [nucleotide binding] 1191061007193 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1191061007194 AAA domain; Region: AAA_21; pfam13304 1191061007195 Winged helix-turn helix; Region: HTH_29; pfam13551 1191061007196 Helix-turn-helix domain; Region: HTH_28; pfam13518 1191061007197 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1191061007198 HAMP domain; Region: HAMP; pfam00672 1191061007199 dimerization interface [polypeptide binding]; other site 1191061007200 GAF domain; Region: GAF; cl17456 1191061007201 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1191061007202 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1191061007203 metal binding site [ion binding]; metal-binding site 1191061007204 active site 1191061007205 I-site; other site 1191061007206 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1191061007207 Zn2+ binding site [ion binding]; other site 1191061007208 Mg2+ binding site [ion binding]; other site 1191061007209 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1191061007210 Zn2+ binding site [ion binding]; other site 1191061007211 Mg2+ binding site [ion binding]; other site 1191061007212 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1191061007213 active site 1191061007214 homotetramer interface [polypeptide binding]; other site 1191061007215 homodimer interface [polypeptide binding]; other site 1191061007216 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 1191061007217 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1191061007218 Walker A/P-loop; other site 1191061007219 ATP binding site [chemical binding]; other site 1191061007220 Q-loop/lid; other site 1191061007221 ABC transporter signature motif; other site 1191061007222 Walker B; other site 1191061007223 D-loop; other site 1191061007224 H-loop/switch region; other site 1191061007225 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1191061007226 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1191061007227 ABC-ATPase subunit interface; other site 1191061007228 dimer interface [polypeptide binding]; other site 1191061007229 putative PBP binding regions; other site 1191061007230 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1191061007231 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1191061007232 ABC-ATPase subunit interface; other site 1191061007233 dimer interface [polypeptide binding]; other site 1191061007234 putative PBP binding regions; other site 1191061007235 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 1191061007236 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1191061007237 siderophore binding site; other site 1191061007238 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 1191061007239 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1191061007240 N-terminal plug; other site 1191061007241 ligand-binding site [chemical binding]; other site 1191061007242 fec operon regulator FecR; Reviewed; Region: PRK09774 1191061007243 FecR protein; Region: FecR; pfam04773 1191061007244 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 1191061007245 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1191061007246 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1191061007247 DNA binding residues [nucleotide binding] 1191061007248 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1191061007249 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191061007250 S-adenosylmethionine binding site [chemical binding]; other site 1191061007251 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1191061007252 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1191061007253 putative acyl-acceptor binding pocket; other site 1191061007254 leucine export protein LeuE; Provisional; Region: PRK10958 1191061007255 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 1191061007256 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1191061007257 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1191061007258 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1191061007259 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1191061007260 metal binding site [ion binding]; metal-binding site 1191061007261 active site 1191061007262 I-site; other site 1191061007263 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 1191061007264 Domain of unknown function (DUF333); Region: DUF333; pfam03891 1191061007265 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1191061007266 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1191061007267 hypothetical protein; Validated; Region: PRK06186 1191061007268 conserved cys residue [active] 1191061007269 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1191061007270 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061007271 Predicted membrane protein [Function unknown]; Region: COG2707 1191061007272 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 1191061007273 putative deacylase active site [active] 1191061007274 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1191061007275 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1191061007276 metal binding site [ion binding]; metal-binding site 1191061007277 active site 1191061007278 I-site; other site 1191061007279 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1191061007280 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1191061007281 hypothetical protein; Provisional; Region: PRK05325 1191061007282 PrkA family serine protein kinase; Provisional; Region: PRK15455 1191061007283 AAA ATPase domain; Region: AAA_16; pfam13191 1191061007284 Walker A motif; other site 1191061007285 ATP binding site [chemical binding]; other site 1191061007286 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1191061007287 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 1191061007288 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1191061007289 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1191061007290 active site 1191061007291 catalytic tetrad [active] 1191061007292 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 1191061007293 active site 1191061007294 phosphate binding residues; other site 1191061007295 catalytic residues [active] 1191061007296 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 1191061007297 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1191061007298 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1191061007299 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1191061007300 SelR domain; Region: SelR; pfam01641 1191061007301 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 1191061007302 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1191061007303 active site 1191061007304 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 1191061007305 Glyco_18 domain; Region: Glyco_18; smart00636 1191061007306 active site 1191061007307 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1191061007308 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 1191061007309 putative NAD(P) binding site [chemical binding]; other site 1191061007310 catalytic Zn binding site [ion binding]; other site 1191061007311 structural Zn binding site [ion binding]; other site 1191061007312 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061007313 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061007314 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 1191061007315 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1191061007316 inhibitor binding site; inhibition site 1191061007317 catalytic Zn binding site [ion binding]; other site 1191061007318 structural Zn binding site [ion binding]; other site 1191061007319 NADP binding site [chemical binding]; other site 1191061007320 tetramer interface [polypeptide binding]; other site 1191061007321 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1191061007322 intersubunit interface [polypeptide binding]; other site 1191061007323 active site 1191061007324 zinc binding site [ion binding]; other site 1191061007325 Na+ binding site [ion binding]; other site 1191061007326 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1191061007327 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1191061007328 substrate binding site [chemical binding]; other site 1191061007329 ATP binding site [chemical binding]; other site 1191061007330 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1191061007331 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1191061007332 active site 1191061007333 catalytic tetrad [active] 1191061007334 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1191061007335 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1191061007336 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1191061007337 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1191061007338 Isochorismatase family; Region: Isochorismatase; pfam00857 1191061007339 catalytic triad [active] 1191061007340 metal binding site [ion binding]; metal-binding site 1191061007341 conserved cis-peptide bond; other site 1191061007342 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1191061007343 active site 1191061007344 homodimer interface [polypeptide binding]; other site 1191061007345 protease 4; Provisional; Region: PRK10949 1191061007346 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1191061007347 tandem repeat interface [polypeptide binding]; other site 1191061007348 oligomer interface [polypeptide binding]; other site 1191061007349 active site residues [active] 1191061007350 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 1191061007351 tandem repeat interface [polypeptide binding]; other site 1191061007352 oligomer interface [polypeptide binding]; other site 1191061007353 active site residues [active] 1191061007354 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1191061007355 putative FMN binding site [chemical binding]; other site 1191061007356 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 1191061007357 active site 1191061007358 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1191061007359 selenophosphate synthetase; Provisional; Region: PRK00943 1191061007360 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1191061007361 dimerization interface [polypeptide binding]; other site 1191061007362 putative ATP binding site [chemical binding]; other site 1191061007363 DNA topoisomerase III; Provisional; Region: PRK07726 1191061007364 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1191061007365 active site 1191061007366 putative interdomain interaction site [polypeptide binding]; other site 1191061007367 putative metal-binding site [ion binding]; other site 1191061007368 putative nucleotide binding site [chemical binding]; other site 1191061007369 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1191061007370 domain I; other site 1191061007371 DNA binding groove [nucleotide binding] 1191061007372 phosphate binding site [ion binding]; other site 1191061007373 domain II; other site 1191061007374 domain III; other site 1191061007375 nucleotide binding site [chemical binding]; other site 1191061007376 catalytic site [active] 1191061007377 domain IV; other site 1191061007378 glutamate dehydrogenase; Provisional; Region: PRK09414 1191061007379 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1191061007380 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1191061007381 NAD(P) binding site [chemical binding]; other site 1191061007382 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1191061007383 active site 1191061007384 8-oxo-dGMP binding site [chemical binding]; other site 1191061007385 nudix motif; other site 1191061007386 metal binding site [ion binding]; metal-binding site 1191061007387 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1191061007388 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1191061007389 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1191061007390 active site residue [active] 1191061007391 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1191061007392 active site residue [active] 1191061007393 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 1191061007394 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1191061007395 Walker A/P-loop; other site 1191061007396 ATP binding site [chemical binding]; other site 1191061007397 Q-loop/lid; other site 1191061007398 ABC transporter signature motif; other site 1191061007399 Walker B; other site 1191061007400 D-loop; other site 1191061007401 H-loop/switch region; other site 1191061007402 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 1191061007403 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 1191061007404 hypothetical protein; Provisional; Region: PRK11622 1191061007405 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1191061007406 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1191061007407 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1191061007408 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1191061007409 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1191061007410 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1191061007411 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1191061007412 putative catalytic site [active] 1191061007413 putative phosphate binding site [ion binding]; other site 1191061007414 active site 1191061007415 metal binding site A [ion binding]; metal-binding site 1191061007416 DNA binding site [nucleotide binding] 1191061007417 putative AP binding site [nucleotide binding]; other site 1191061007418 putative metal binding site B [ion binding]; other site 1191061007419 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 1191061007420 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1191061007421 inhibitor-cofactor binding pocket; inhibition site 1191061007422 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061007423 catalytic residue [active] 1191061007424 arginine succinyltransferase; Provisional; Region: PRK10456 1191061007425 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1191061007426 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 1191061007427 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 1191061007428 NAD(P) binding site [chemical binding]; other site 1191061007429 catalytic residues [active] 1191061007430 succinylarginine dihydrolase; Provisional; Region: PRK13281 1191061007431 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 1191061007432 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1191061007433 putative active site [active] 1191061007434 Zn binding site [ion binding]; other site 1191061007435 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1191061007436 dimer interface [polypeptide binding]; other site 1191061007437 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1191061007438 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 1191061007439 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 1191061007440 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1191061007441 GIY-YIG motif/motif A; other site 1191061007442 active site 1191061007443 catalytic site [active] 1191061007444 putative DNA binding site [nucleotide binding]; other site 1191061007445 metal binding site [ion binding]; metal-binding site 1191061007446 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1191061007447 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1191061007448 homodimer interface [polypeptide binding]; other site 1191061007449 NAD binding pocket [chemical binding]; other site 1191061007450 ATP binding pocket [chemical binding]; other site 1191061007451 Mg binding site [ion binding]; other site 1191061007452 active-site loop [active] 1191061007453 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 1191061007454 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1191061007455 active site 1191061007456 P-loop; other site 1191061007457 phosphorylation site [posttranslational modification] 1191061007458 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 1191061007459 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1191061007460 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1191061007461 methionine cluster; other site 1191061007462 active site 1191061007463 phosphorylation site [posttranslational modification] 1191061007464 metal binding site [ion binding]; metal-binding site 1191061007465 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 1191061007466 Cupin domain; Region: Cupin_2; pfam07883 1191061007467 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061007468 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1191061007469 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1191061007470 NAD binding site [chemical binding]; other site 1191061007471 sugar binding site [chemical binding]; other site 1191061007472 divalent metal binding site [ion binding]; other site 1191061007473 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1191061007474 dimer interface [polypeptide binding]; other site 1191061007475 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 1191061007476 putative active site [active] 1191061007477 YdjC motif; other site 1191061007478 Mg binding site [ion binding]; other site 1191061007479 putative homodimer interface [polypeptide binding]; other site 1191061007480 hydroperoxidase II; Provisional; Region: katE; PRK11249 1191061007481 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1191061007482 tetramer interface [polypeptide binding]; other site 1191061007483 heme binding pocket [chemical binding]; other site 1191061007484 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1191061007485 domain interactions; other site 1191061007486 cell division modulator; Provisional; Region: PRK10113 1191061007487 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1191061007488 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1191061007489 inner membrane protein; Provisional; Region: PRK11648 1191061007490 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 1191061007491 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1191061007492 NADP binding site [chemical binding]; other site 1191061007493 homodimer interface [polypeptide binding]; other site 1191061007494 active site 1191061007495 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 1191061007496 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1191061007497 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1191061007498 motif II; other site 1191061007499 YniB-like protein; Region: YniB; pfam14002 1191061007500 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1191061007501 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 1191061007502 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1191061007503 putative Cl- selectivity filter; other site 1191061007504 putative pore gating glutamate residue; other site 1191061007505 intracellular septation protein A; Reviewed; Region: PRK00259 1191061007506 hypothetical protein; Provisional; Region: PRK02868 1191061007507 outer membrane protein W; Provisional; Region: PRK10959 1191061007508 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 1191061007509 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1191061007510 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1191061007511 DNA binding residues [nucleotide binding] 1191061007512 dimerization interface [polypeptide binding]; other site 1191061007513 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 1191061007514 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061007515 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1191061007516 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1191061007517 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1191061007518 NAD(P) binding site [chemical binding]; other site 1191061007519 active site 1191061007520 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061007521 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061007522 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 1191061007523 putative substrate binding pocket [chemical binding]; other site 1191061007524 putative dimerization interface [polypeptide binding]; other site 1191061007525 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1191061007526 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1191061007527 putative NAD(P) binding site [chemical binding]; other site 1191061007528 MarR family; Region: MarR_2; pfam12802 1191061007529 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1191061007530 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1191061007531 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1191061007532 substrate binding site [chemical binding]; other site 1191061007533 active site 1191061007534 catalytic residues [active] 1191061007535 heterodimer interface [polypeptide binding]; other site 1191061007536 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1191061007537 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1191061007538 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061007539 catalytic residue [active] 1191061007540 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 1191061007541 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1191061007542 active site 1191061007543 ribulose/triose binding site [chemical binding]; other site 1191061007544 phosphate binding site [ion binding]; other site 1191061007545 substrate (anthranilate) binding pocket [chemical binding]; other site 1191061007546 product (indole) binding pocket [chemical binding]; other site 1191061007547 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1191061007548 active site 1191061007549 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 1191061007550 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1191061007551 glutamine binding [chemical binding]; other site 1191061007552 catalytic triad [active] 1191061007553 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1191061007554 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1191061007555 anthranilate synthase component I; Provisional; Region: PRK13564 1191061007556 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1191061007557 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1191061007558 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1191061007559 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1191061007560 active site 1191061007561 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1191061007562 hypothetical protein; Provisional; Region: PRK11630 1191061007563 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 1191061007564 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1191061007565 RNA binding surface [nucleotide binding]; other site 1191061007566 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 1191061007567 probable active site [active] 1191061007568 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1191061007569 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1191061007570 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1191061007571 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1191061007572 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1191061007573 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1191061007574 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061007575 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061007576 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1191061007577 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1191061007578 homodimer interface [polypeptide binding]; other site 1191061007579 Walker A motif; other site 1191061007580 ATP binding site [chemical binding]; other site 1191061007581 hydroxycobalamin binding site [chemical binding]; other site 1191061007582 Walker B motif; other site 1191061007583 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 1191061007584 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 1191061007585 NADP binding site [chemical binding]; other site 1191061007586 homodimer interface [polypeptide binding]; other site 1191061007587 active site 1191061007588 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 1191061007589 putative inner membrane peptidase; Provisional; Region: PRK11778 1191061007590 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1191061007591 tandem repeat interface [polypeptide binding]; other site 1191061007592 oligomer interface [polypeptide binding]; other site 1191061007593 active site residues [active] 1191061007594 hypothetical protein; Provisional; Region: PRK11037 1191061007595 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1191061007596 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1191061007597 active site 1191061007598 interdomain interaction site; other site 1191061007599 putative metal-binding site [ion binding]; other site 1191061007600 nucleotide binding site [chemical binding]; other site 1191061007601 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1191061007602 domain I; other site 1191061007603 DNA binding groove [nucleotide binding] 1191061007604 phosphate binding site [ion binding]; other site 1191061007605 domain II; other site 1191061007606 domain III; other site 1191061007607 nucleotide binding site [chemical binding]; other site 1191061007608 catalytic site [active] 1191061007609 domain IV; other site 1191061007610 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1191061007611 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1191061007612 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1191061007613 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1191061007614 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 1191061007615 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061007616 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 1191061007617 substrate binding site [chemical binding]; other site 1191061007618 putative dimerization interface [polypeptide binding]; other site 1191061007619 aconitate hydratase; Validated; Region: PRK09277 1191061007620 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1191061007621 substrate binding site [chemical binding]; other site 1191061007622 ligand binding site [chemical binding]; other site 1191061007623 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1191061007624 substrate binding site [chemical binding]; other site 1191061007625 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1191061007626 dimerization interface [polypeptide binding]; other site 1191061007627 active site 1191061007628 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1191061007629 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1191061007630 active site 1191061007631 Predicted membrane protein [Function unknown]; Region: COG3771 1191061007632 tetratricopeptide repeat protein; Provisional; Region: PRK11788 1191061007633 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191061007634 TPR motif; other site 1191061007635 binding surface 1191061007636 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1191061007637 active site 1191061007638 dimer interface [polypeptide binding]; other site 1191061007639 translation initiation factor Sui1; Validated; Region: PRK06824 1191061007640 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 1191061007641 putative rRNA binding site [nucleotide binding]; other site 1191061007642 lipoprotein; Provisional; Region: PRK10540 1191061007643 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1191061007644 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1191061007645 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1191061007646 hypothetical protein; Provisional; Region: PRK13658 1191061007647 exoribonuclease II; Provisional; Region: PRK05054 1191061007648 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1191061007649 RNB domain; Region: RNB; pfam00773 1191061007650 S1 RNA binding domain; Region: S1; pfam00575 1191061007651 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 1191061007652 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1191061007653 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1191061007654 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 1191061007655 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1191061007656 NAD binding site [chemical binding]; other site 1191061007657 homotetramer interface [polypeptide binding]; other site 1191061007658 homodimer interface [polypeptide binding]; other site 1191061007659 substrate binding site [chemical binding]; other site 1191061007660 active site 1191061007661 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 1191061007662 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1191061007663 Walker A/P-loop; other site 1191061007664 ATP binding site [chemical binding]; other site 1191061007665 Q-loop/lid; other site 1191061007666 ABC transporter signature motif; other site 1191061007667 Walker B; other site 1191061007668 D-loop; other site 1191061007669 H-loop/switch region; other site 1191061007670 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 1191061007671 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1191061007672 Walker A/P-loop; other site 1191061007673 ATP binding site [chemical binding]; other site 1191061007674 Q-loop/lid; other site 1191061007675 ABC transporter signature motif; other site 1191061007676 Walker B; other site 1191061007677 D-loop; other site 1191061007678 H-loop/switch region; other site 1191061007679 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1191061007680 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 1191061007681 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1191061007682 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061007683 putative PBP binding loops; other site 1191061007684 dimer interface [polypeptide binding]; other site 1191061007685 ABC-ATPase subunit interface; other site 1191061007686 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 1191061007687 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061007688 dimer interface [polypeptide binding]; other site 1191061007689 conserved gate region; other site 1191061007690 putative PBP binding loops; other site 1191061007691 ABC-ATPase subunit interface; other site 1191061007692 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1191061007693 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1191061007694 peptide binding site [polypeptide binding]; other site 1191061007695 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061007696 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1191061007697 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 1191061007698 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1191061007699 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1191061007700 metal binding site [ion binding]; metal-binding site 1191061007701 putative dimer interface [polypeptide binding]; other site 1191061007702 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1191061007703 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061007704 putative substrate translocation pore; other site 1191061007705 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 1191061007706 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191061007707 Walker A motif; other site 1191061007708 ATP binding site [chemical binding]; other site 1191061007709 Walker B motif; other site 1191061007710 arginine finger; other site 1191061007711 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1191061007712 phage shock protein PspA; Provisional; Region: PRK10698 1191061007713 phage shock protein B; Provisional; Region: pspB; PRK09458 1191061007714 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 1191061007715 phage shock protein C; Region: phageshock_pspC; TIGR02978 1191061007716 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 1191061007717 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1191061007718 active site residue [active] 1191061007719 Predicted ATPase [General function prediction only]; Region: COG3106 1191061007720 hypothetical protein; Provisional; Region: PRK05415 1191061007721 Domain of unknown function (DUF697); Region: DUF697; cl12064 1191061007722 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 1191061007723 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1191061007724 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191061007725 putative active site [active] 1191061007726 heme pocket [chemical binding]; other site 1191061007727 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191061007728 Walker A motif; other site 1191061007729 ATP binding site [chemical binding]; other site 1191061007730 Walker B motif; other site 1191061007731 arginine finger; other site 1191061007732 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 1191061007733 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1191061007734 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1191061007735 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1191061007736 dimer interface [polypeptide binding]; other site 1191061007737 catalytic triad [active] 1191061007738 peroxidatic and resolving cysteines [active] 1191061007739 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 1191061007740 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1191061007741 active site 1191061007742 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 1191061007743 putative active site [active] 1191061007744 Zn binding site [ion binding]; other site 1191061007745 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1191061007746 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1191061007747 peptide binding site [polypeptide binding]; other site 1191061007748 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1191061007749 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1191061007750 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1191061007751 Walker A/P-loop; other site 1191061007752 ATP binding site [chemical binding]; other site 1191061007753 Q-loop/lid; other site 1191061007754 ABC transporter signature motif; other site 1191061007755 Walker B; other site 1191061007756 D-loop; other site 1191061007757 H-loop/switch region; other site 1191061007758 NIL domain; Region: NIL; cl09633 1191061007759 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061007760 dimer interface [polypeptide binding]; other site 1191061007761 conserved gate region; other site 1191061007762 ABC-ATPase subunit interface; other site 1191061007763 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 1191061007764 benzoate transport; Region: 2A0115; TIGR00895 1191061007765 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061007766 putative substrate translocation pore; other site 1191061007767 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061007768 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1191061007769 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 1191061007770 Flavin binding site [chemical binding]; other site 1191061007771 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 1191061007772 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1191061007773 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061007774 dimer interface [polypeptide binding]; other site 1191061007775 conserved gate region; other site 1191061007776 putative PBP binding loops; other site 1191061007777 ABC-ATPase subunit interface; other site 1191061007778 substrate binding pocket [chemical binding]; other site 1191061007779 NMT1-like family; Region: NMT1_2; pfam13379 1191061007780 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1191061007781 membrane-bound complex binding site; other site 1191061007782 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1191061007783 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1191061007784 ABC transporter signature motif; other site 1191061007785 Walker B; other site 1191061007786 D-loop; other site 1191061007787 H-loop/switch region; other site 1191061007788 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1191061007789 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1191061007790 DNA-binding site [nucleotide binding]; DNA binding site 1191061007791 UTRA domain; Region: UTRA; pfam07702 1191061007792 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1191061007793 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1191061007794 carboxyltransferase (CT) interaction site; other site 1191061007795 biotinylation site [posttranslational modification]; other site 1191061007796 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1191061007797 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1191061007798 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1191061007799 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1191061007800 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1191061007801 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1191061007802 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1191061007803 NAD(P) binding site [chemical binding]; other site 1191061007804 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1191061007805 EamA-like transporter family; Region: EamA; pfam00892 1191061007806 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1191061007807 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1191061007808 substrate binding pocket [chemical binding]; other site 1191061007809 membrane-bound complex binding site; other site 1191061007810 hinge residues; other site 1191061007811 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1191061007812 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1191061007813 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1191061007814 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1191061007815 putative active site [active] 1191061007816 aspartate aminotransferase; Provisional; Region: PRK05764 1191061007817 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1191061007818 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061007819 homodimer interface [polypeptide binding]; other site 1191061007820 catalytic residue [active] 1191061007821 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 1191061007822 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061007823 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 1191061007824 putative dimerization interface [polypeptide binding]; other site 1191061007825 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1191061007826 classical (c) SDRs; Region: SDR_c; cd05233 1191061007827 NAD(P) binding site [chemical binding]; other site 1191061007828 active site 1191061007829 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061007830 dimer interface [polypeptide binding]; other site 1191061007831 conserved gate region; other site 1191061007832 putative PBP binding loops; other site 1191061007833 ABC-ATPase subunit interface; other site 1191061007834 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061007835 dimer interface [polypeptide binding]; other site 1191061007836 conserved gate region; other site 1191061007837 putative PBP binding loops; other site 1191061007838 ABC-ATPase subunit interface; other site 1191061007839 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1191061007840 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1191061007841 Walker A/P-loop; other site 1191061007842 ATP binding site [chemical binding]; other site 1191061007843 Q-loop/lid; other site 1191061007844 ABC transporter signature motif; other site 1191061007845 Walker B; other site 1191061007846 D-loop; other site 1191061007847 H-loop/switch region; other site 1191061007848 Chorismate mutase type II; Region: CM_2; cl00693 1191061007849 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1191061007850 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1191061007851 substrate binding pocket [chemical binding]; other site 1191061007852 membrane-bound complex binding site; other site 1191061007853 hinge residues; other site 1191061007854 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1191061007855 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1191061007856 Walker A/P-loop; other site 1191061007857 ATP binding site [chemical binding]; other site 1191061007858 Q-loop/lid; other site 1191061007859 ABC transporter signature motif; other site 1191061007860 Walker B; other site 1191061007861 D-loop; other site 1191061007862 H-loop/switch region; other site 1191061007863 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1191061007864 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061007865 dimer interface [polypeptide binding]; other site 1191061007866 conserved gate region; other site 1191061007867 putative PBP binding loops; other site 1191061007868 ABC-ATPase subunit interface; other site 1191061007869 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 1191061007870 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1191061007871 active site 1191061007872 motif I; other site 1191061007873 motif II; other site 1191061007874 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1191061007875 serine O-acetyltransferase; Region: cysE; TIGR01172 1191061007876 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1191061007877 trimer interface [polypeptide binding]; other site 1191061007878 active site 1191061007879 substrate binding site [chemical binding]; other site 1191061007880 CoA binding site [chemical binding]; other site 1191061007881 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1191061007882 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1191061007883 dimer interface [polypeptide binding]; other site 1191061007884 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061007885 catalytic residue [active] 1191061007886 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 1191061007887 MPN+ (JAMM) motif; other site 1191061007888 Zinc-binding site [ion binding]; other site 1191061007889 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1191061007890 MoaE interaction surface [polypeptide binding]; other site 1191061007891 MoeB interaction surface [polypeptide binding]; other site 1191061007892 thiocarboxylated glycine; other site 1191061007893 hypothetical protein; Validated; Region: PRK07411 1191061007894 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1191061007895 ATP binding site [chemical binding]; other site 1191061007896 substrate interface [chemical binding]; other site 1191061007897 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1191061007898 active site residue [active] 1191061007899 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1191061007900 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1191061007901 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1191061007902 catalytic residue [active] 1191061007903 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1191061007904 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061007905 putative PBP binding loops; other site 1191061007906 dimer interface [polypeptide binding]; other site 1191061007907 ABC-ATPase subunit interface; other site 1191061007908 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1191061007909 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1191061007910 Walker A/P-loop; other site 1191061007911 ATP binding site [chemical binding]; other site 1191061007912 Q-loop/lid; other site 1191061007913 ABC transporter signature motif; other site 1191061007914 Walker B; other site 1191061007915 D-loop; other site 1191061007916 H-loop/switch region; other site 1191061007917 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1191061007918 NMT1-like family; Region: NMT1_2; pfam13379 1191061007919 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 1191061007920 D-cysteine desulfhydrase; Validated; Region: PRK03910 1191061007921 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1191061007922 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1191061007923 catalytic residue [active] 1191061007924 aspartate racemase; Region: asp_race; TIGR00035 1191061007925 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1191061007926 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 1191061007927 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1191061007928 substrate binding pocket [chemical binding]; other site 1191061007929 membrane-bound complex binding site; other site 1191061007930 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1191061007931 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061007932 dimer interface [polypeptide binding]; other site 1191061007933 conserved gate region; other site 1191061007934 putative PBP binding loops; other site 1191061007935 ABC-ATPase subunit interface; other site 1191061007936 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1191061007937 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 1191061007938 conserved cys residue [active] 1191061007939 Protein of unknown function (DUF770); Region: DUF770; pfam05591 1191061007940 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 1191061007941 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1191061007942 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 1191061007943 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1191061007944 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 1191061007945 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1191061007946 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1191061007947 ligand binding site [chemical binding]; other site 1191061007948 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 1191061007949 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1191061007950 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191061007951 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1191061007952 Walker A motif; other site 1191061007953 ATP binding site [chemical binding]; other site 1191061007954 Walker B motif; other site 1191061007955 arginine finger; other site 1191061007956 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191061007957 Walker A motif; other site 1191061007958 ATP binding site [chemical binding]; other site 1191061007959 Walker B motif; other site 1191061007960 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1191061007961 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 1191061007962 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1191061007963 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1191061007964 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 1191061007965 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 1191061007966 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1191061007967 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 1191061007968 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 1191061007969 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 1191061007970 PAAR motif; Region: PAAR_motif; pfam05488 1191061007971 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1191061007972 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 1191061007973 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 1191061007974 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 1191061007975 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1191061007976 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 1191061007977 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1191061007978 ImpA domain protein; Region: DUF3702; pfam12486 1191061007979 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1191061007980 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1191061007981 inhibitor binding site; inhibition site 1191061007982 active site 1191061007983 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1191061007984 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1191061007985 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1191061007986 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1191061007987 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1191061007988 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1191061007989 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061007990 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061007991 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1191061007992 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1191061007993 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061007994 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1191061007995 putative substrate translocation pore; other site 1191061007996 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1191061007997 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616 1191061007998 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1191061007999 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 1191061008000 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061008001 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1191061008002 Hypothetical protein (DUF2410); Region: DUF2410; pfam10307 1191061008003 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1191061008004 Protein of unknown function (DUF523); Region: DUF523; cl00733 1191061008005 Uncharacterized conserved protein [Function unknown]; Region: COG3272 1191061008006 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 1191061008007 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 1191061008008 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1191061008009 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191061008010 S-adenosylmethionine binding site [chemical binding]; other site 1191061008011 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 1191061008012 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 1191061008013 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1191061008014 short chain dehydrogenase; Provisional; Region: PRK06101 1191061008015 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1191061008016 NAD(P) binding site [chemical binding]; other site 1191061008017 active site 1191061008018 SnoaL-like domain; Region: SnoaL_2; pfam12680 1191061008019 transcriptional regulator MirA; Provisional; Region: PRK15043 1191061008020 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1191061008021 DNA binding residues [nucleotide binding] 1191061008022 Predicted membrane protein [Function unknown]; Region: COG3326 1191061008023 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1191061008024 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061008025 putative substrate translocation pore; other site 1191061008026 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061008027 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061008028 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1191061008029 putative effector binding pocket; other site 1191061008030 putative dimerization interface [polypeptide binding]; other site 1191061008031 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061008032 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061008033 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1191061008034 putative effector binding pocket; other site 1191061008035 putative dimerization interface [polypeptide binding]; other site 1191061008036 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1191061008037 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1191061008038 FMN binding site [chemical binding]; other site 1191061008039 substrate binding site [chemical binding]; other site 1191061008040 putative catalytic residue [active] 1191061008041 short chain dehydrogenase; Validated; Region: PRK06182 1191061008042 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1191061008043 NADP binding site [chemical binding]; other site 1191061008044 active site 1191061008045 steroid binding site; other site 1191061008046 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1191061008047 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1191061008048 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 1191061008049 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 1191061008050 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 1191061008051 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 1191061008052 active site 1191061008053 P-loop; other site 1191061008054 phosphorylation site [posttranslational modification] 1191061008055 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1191061008056 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1191061008057 Catalytic site [active] 1191061008058 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 1191061008059 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1191061008060 active site 1191061008061 DNA binding site [nucleotide binding] 1191061008062 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1191061008063 putative oxidoreductase; Provisional; Region: PRK11579 1191061008064 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1191061008065 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1191061008066 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1191061008067 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1191061008068 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1191061008069 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1191061008070 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1191061008071 DNA binding residues [nucleotide binding] 1191061008072 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1191061008073 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 1191061008074 Cl binding site [ion binding]; other site 1191061008075 oligomer interface [polypeptide binding]; other site 1191061008076 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 1191061008077 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1191061008078 ATP binding site [chemical binding]; other site 1191061008079 Mg++ binding site [ion binding]; other site 1191061008080 motif III; other site 1191061008081 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1191061008082 nucleotide binding region [chemical binding]; other site 1191061008083 ATP-binding site [chemical binding]; other site 1191061008084 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 1191061008085 putative RNA binding site [nucleotide binding]; other site 1191061008086 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1191061008087 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1191061008088 Ligand Binding Site [chemical binding]; other site 1191061008089 outer membrane protease; Reviewed; Region: PRK10993 1191061008090 Bor protein; Region: Lambda_Bor; pfam06291 1191061008091 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1191061008092 Ligand Binding Site [chemical binding]; other site 1191061008093 KTSC domain; Region: KTSC; pfam13619 1191061008094 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1191061008095 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1191061008096 trimer interface [polypeptide binding]; other site 1191061008097 eyelet of channel; other site 1191061008098 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1191061008099 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1191061008100 dimer interface [polypeptide binding]; other site 1191061008101 PYR/PP interface [polypeptide binding]; other site 1191061008102 TPP binding site [chemical binding]; other site 1191061008103 substrate binding site [chemical binding]; other site 1191061008104 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1191061008105 Domain of unknown function; Region: EKR; pfam10371 1191061008106 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1191061008107 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1191061008108 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 1191061008109 TPP-binding site [chemical binding]; other site 1191061008110 dimer interface [polypeptide binding]; other site 1191061008111 Predicted transcriptional regulator [Transcription]; Region: COG2932 1191061008112 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1191061008113 Catalytic site [active] 1191061008114 Protein of unknown function (DUF754); Region: DUF754; pfam05449 1191061008115 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 1191061008116 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 1191061008117 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 1191061008118 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 1191061008119 Domain of unknown function (DUF333); Region: DUF333; pfam03891 1191061008120 META domain; Region: META; cl01245 1191061008121 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 1191061008122 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1191061008123 putative ligand binding site [chemical binding]; other site 1191061008124 putative NAD binding site [chemical binding]; other site 1191061008125 catalytic site [active] 1191061008126 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1191061008127 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1191061008128 hypothetical protein; Provisional; Region: PRK10695 1191061008129 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 1191061008130 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 1191061008131 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 1191061008132 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061008133 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1191061008134 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1191061008135 NAD(P) binding site [chemical binding]; other site 1191061008136 catalytic residues [active] 1191061008137 hypothetical protein; Provisional; Region: PRK07490 1191061008138 active site 1191061008139 Zn2+ binding site [ion binding]; other site 1191061008140 intersubunit interface [polypeptide binding]; other site 1191061008141 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1191061008142 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1191061008143 substrate binding pocket [chemical binding]; other site 1191061008144 membrane-bound complex binding site; other site 1191061008145 hinge residues; other site 1191061008146 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1191061008147 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061008148 dimer interface [polypeptide binding]; other site 1191061008149 conserved gate region; other site 1191061008150 putative PBP binding loops; other site 1191061008151 ABC-ATPase subunit interface; other site 1191061008152 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1191061008153 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1191061008154 Walker A/P-loop; other site 1191061008155 ATP binding site [chemical binding]; other site 1191061008156 Q-loop/lid; other site 1191061008157 ABC transporter signature motif; other site 1191061008158 Walker B; other site 1191061008159 D-loop; other site 1191061008160 H-loop/switch region; other site 1191061008161 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061008162 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061008163 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 1191061008164 putative substrate binding pocket [chemical binding]; other site 1191061008165 dimerization interface [polypeptide binding]; other site 1191061008166 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 1191061008167 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1191061008168 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1191061008169 homotrimer interaction site [polypeptide binding]; other site 1191061008170 putative active site [active] 1191061008171 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 1191061008172 acetylornithine deacetylase; Provisional; Region: PRK07522 1191061008173 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1191061008174 metal binding site [ion binding]; metal-binding site 1191061008175 putative dimer interface [polypeptide binding]; other site 1191061008176 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1191061008177 DinB family; Region: DinB; cl17821 1191061008178 DinB superfamily; Region: DinB_2; pfam12867 1191061008179 RibD C-terminal domain; Region: RibD_C; cl17279 1191061008180 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1191061008181 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 1191061008182 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1191061008183 Cupin domain; Region: Cupin_2; cl17218 1191061008184 Cupin domain; Region: Cupin_2; cl17218 1191061008185 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1191061008186 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1191061008187 HlyD family secretion protein; Region: HlyD_3; pfam13437 1191061008188 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1191061008189 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1191061008190 Cupin domain; Region: Cupin_2; cl17218 1191061008191 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1191061008192 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061008193 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1191061008194 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061008195 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061008196 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1191061008197 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1191061008198 HlyD family secretion protein; Region: HlyD_3; pfam13437 1191061008199 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1191061008200 Predicted transcriptional regulator [Transcription]; Region: COG1959 1191061008201 Transcriptional regulator; Region: Rrf2; pfam02082 1191061008202 Transcriptional regulator; Region: Rrf2; cl17282 1191061008203 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1191061008204 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1191061008205 NAD(P) binding site [chemical binding]; other site 1191061008206 active site 1191061008207 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191061008208 TPR motif; other site 1191061008209 binding surface 1191061008210 TPR repeat; Region: TPR_11; pfam13414 1191061008211 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1191061008212 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1191061008213 DNA-binding site [nucleotide binding]; DNA binding site 1191061008214 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1191061008215 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061008216 homodimer interface [polypeptide binding]; other site 1191061008217 catalytic residue [active] 1191061008218 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 1191061008219 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1191061008220 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1191061008221 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1191061008222 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1191061008223 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1191061008224 conserved cys residue [active] 1191061008225 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061008226 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061008227 GIY-YIG catalytic domain; Region: GIY-YIG; pfam01541 1191061008228 GIY-YIG motif/motif A; other site 1191061008229 active site 1191061008230 catalytic site [active] 1191061008231 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061008232 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061008233 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1191061008234 putative effector binding pocket; other site 1191061008235 dimerization interface [polypeptide binding]; other site 1191061008236 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1191061008237 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1191061008238 NAD(P) binding site [chemical binding]; other site 1191061008239 active site 1191061008240 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1191061008241 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 1191061008242 tyramine oxidase; Provisional; Region: tynA; PRK14696 1191061008243 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1191061008244 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 1191061008245 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 1191061008246 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 1191061008247 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 1191061008248 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 1191061008249 substrate binding site [chemical binding]; other site 1191061008250 dimer interface [polypeptide binding]; other site 1191061008251 NADP binding site [chemical binding]; other site 1191061008252 catalytic residues [active] 1191061008253 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 1191061008254 substrate binding site [chemical binding]; other site 1191061008255 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 1191061008256 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 1191061008257 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 1191061008258 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 1191061008259 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1191061008260 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 1191061008261 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1191061008262 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1191061008263 FAD binding pocket [chemical binding]; other site 1191061008264 FAD binding motif [chemical binding]; other site 1191061008265 phosphate binding motif [ion binding]; other site 1191061008266 beta-alpha-beta structure motif; other site 1191061008267 NAD(p) ribose binding residues [chemical binding]; other site 1191061008268 NAD binding pocket [chemical binding]; other site 1191061008269 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1191061008270 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1191061008271 catalytic loop [active] 1191061008272 iron binding site [ion binding]; other site 1191061008273 enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674 1191061008274 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1191061008275 substrate binding site [chemical binding]; other site 1191061008276 oxyanion hole (OAH) forming residues; other site 1191061008277 trimer interface [polypeptide binding]; other site 1191061008278 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1191061008279 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1191061008280 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1191061008281 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1191061008282 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1191061008283 CoenzymeA binding site [chemical binding]; other site 1191061008284 subunit interaction site [polypeptide binding]; other site 1191061008285 PHB binding site; other site 1191061008286 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 1191061008287 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1191061008288 dimer interface [polypeptide binding]; other site 1191061008289 active site 1191061008290 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 1191061008291 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 1191061008292 active site 1191061008293 AMP binding site [chemical binding]; other site 1191061008294 homodimer interface [polypeptide binding]; other site 1191061008295 acyl-activating enzyme (AAE) consensus motif; other site 1191061008296 CoA binding site [chemical binding]; other site 1191061008297 PaaX-like protein; Region: PaaX; pfam07848 1191061008298 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 1191061008299 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1191061008300 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 1191061008301 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 1191061008302 putative trimer interface [polypeptide binding]; other site 1191061008303 putative metal binding site [ion binding]; other site 1191061008304 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1191061008305 azoreductase; Reviewed; Region: PRK00170 1191061008306 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1191061008307 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 1191061008308 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1191061008309 ATP binding site [chemical binding]; other site 1191061008310 putative Mg++ binding site [ion binding]; other site 1191061008311 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1191061008312 nucleotide binding region [chemical binding]; other site 1191061008313 ATP-binding site [chemical binding]; other site 1191061008314 Helicase associated domain (HA2); Region: HA2; pfam04408 1191061008315 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1191061008316 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1191061008317 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1191061008318 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191061008319 S-adenosylmethionine binding site [chemical binding]; other site 1191061008320 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1191061008321 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1191061008322 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1191061008323 HlyD family secretion protein; Region: HlyD_3; pfam13437 1191061008324 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061008325 putative substrate translocation pore; other site 1191061008326 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1191061008327 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1191061008328 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1191061008329 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1191061008330 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1191061008331 NAD(P) binding site [chemical binding]; other site 1191061008332 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1191061008333 putative active site [active] 1191061008334 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 1191061008335 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1191061008336 NAD binding site [chemical binding]; other site 1191061008337 catalytic residues [active] 1191061008338 substrate binding site [chemical binding]; other site 1191061008339 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1191061008340 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1191061008341 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1191061008342 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1191061008343 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1191061008344 Coenzyme A binding pocket [chemical binding]; other site 1191061008345 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061008346 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061008347 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1191061008348 dimerization interface [polypeptide binding]; other site 1191061008349 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1191061008350 GAF domain; Region: GAF; pfam01590 1191061008351 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1191061008352 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1191061008353 metal binding site [ion binding]; metal-binding site 1191061008354 active site 1191061008355 I-site; other site 1191061008356 YdfZ protein; Region: YdfZ; cl11878 1191061008357 DinI-like family; Region: DinI; cl11630 1191061008358 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1191061008359 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 1191061008360 putative metal binding site [ion binding]; other site 1191061008361 putative homodimer interface [polypeptide binding]; other site 1191061008362 putative homotetramer interface [polypeptide binding]; other site 1191061008363 putative homodimer-homodimer interface [polypeptide binding]; other site 1191061008364 putative allosteric switch controlling residues; other site 1191061008365 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1191061008366 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 1191061008367 substrate binding site [chemical binding]; other site 1191061008368 catalytic Zn binding site [ion binding]; other site 1191061008369 NAD binding site [chemical binding]; other site 1191061008370 structural Zn binding site [ion binding]; other site 1191061008371 dimer interface [polypeptide binding]; other site 1191061008372 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1191061008373 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1191061008374 Trp docking motif [polypeptide binding]; other site 1191061008375 putative active site [active] 1191061008376 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1191061008377 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061008378 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 1191061008379 putative dimerization interface [polypeptide binding]; other site 1191061008380 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 1191061008381 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 1191061008382 heterodimer interface [polypeptide binding]; other site 1191061008383 active site 1191061008384 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 1191061008385 heterodimer interface [polypeptide binding]; other site 1191061008386 multimer interface [polypeptide binding]; other site 1191061008387 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 1191061008388 active site 1191061008389 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 1191061008390 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 1191061008391 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1191061008392 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1191061008393 substrate binding pocket [chemical binding]; other site 1191061008394 catalytic triad [active] 1191061008395 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 1191061008396 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 1191061008397 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1191061008398 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1191061008399 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1191061008400 putative trimer interface [polypeptide binding]; other site 1191061008401 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1191061008402 putative trimer interface [polypeptide binding]; other site 1191061008403 putative CoA binding site [chemical binding]; other site 1191061008404 putative CoA binding site [chemical binding]; other site 1191061008405 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 1191061008406 putative trimer interface [polypeptide binding]; other site 1191061008407 putative CoA binding site [chemical binding]; other site 1191061008408 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1191061008409 putative trimer interface [polypeptide binding]; other site 1191061008410 putative CoA binding site [chemical binding]; other site 1191061008411 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1191061008412 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 1191061008413 gating phenylalanine in ion channel; other site 1191061008414 tellurite resistance protein TehB; Provisional; Region: PRK11207 1191061008415 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191061008416 S-adenosylmethionine binding site [chemical binding]; other site 1191061008417 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 1191061008418 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1191061008419 metal binding site [ion binding]; metal-binding site 1191061008420 dimer interface [polypeptide binding]; other site 1191061008421 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1191061008422 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1191061008423 peptide binding site [polypeptide binding]; other site 1191061008424 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 1191061008425 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1191061008426 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1191061008427 EamA-like transporter family; Region: EamA; pfam00892 1191061008428 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061008429 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1191061008430 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061008431 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 1191061008432 benzoate transporter; Region: benE; TIGR00843 1191061008433 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1191061008434 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1191061008435 non-specific DNA binding site [nucleotide binding]; other site 1191061008436 salt bridge; other site 1191061008437 sequence-specific DNA binding site [nucleotide binding]; other site 1191061008438 Cupin domain; Region: Cupin_2; pfam07883 1191061008439 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1191061008440 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1191061008441 Peptidase family U32; Region: Peptidase_U32; pfam01136 1191061008442 Collagenase; Region: DUF3656; pfam12392 1191061008443 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 1191061008444 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 1191061008445 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1191061008446 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1191061008447 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1191061008448 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1191061008449 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1191061008450 DNA-binding site [nucleotide binding]; DNA binding site 1191061008451 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1191061008452 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061008453 homodimer interface [polypeptide binding]; other site 1191061008454 catalytic residue [active] 1191061008455 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1191061008456 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1191061008457 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1191061008458 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1191061008459 Walker A/P-loop; other site 1191061008460 ATP binding site [chemical binding]; other site 1191061008461 Q-loop/lid; other site 1191061008462 ABC transporter signature motif; other site 1191061008463 Walker B; other site 1191061008464 D-loop; other site 1191061008465 H-loop/switch region; other site 1191061008466 TOBE domain; Region: TOBE_2; pfam08402 1191061008467 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061008468 dimer interface [polypeptide binding]; other site 1191061008469 conserved gate region; other site 1191061008470 putative PBP binding loops; other site 1191061008471 ABC-ATPase subunit interface; other site 1191061008472 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1191061008473 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1191061008474 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 1191061008475 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 1191061008476 tetrameric interface [polypeptide binding]; other site 1191061008477 NAD binding site [chemical binding]; other site 1191061008478 catalytic residues [active] 1191061008479 substrate binding site [chemical binding]; other site 1191061008480 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 1191061008481 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1191061008482 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1191061008483 catalytic site [active] 1191061008484 acyl-CoA thioesterase; Provisional; Region: PRK10531 1191061008485 putative pectinesterase; Region: PLN02432; cl01911 1191061008486 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1191061008487 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1191061008488 NAD(P) binding site [chemical binding]; other site 1191061008489 catalytic residues [active] 1191061008490 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1191061008491 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1191061008492 peptide binding site [polypeptide binding]; other site 1191061008493 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 1191061008494 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1191061008495 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1191061008496 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1191061008497 Coenzyme A binding pocket [chemical binding]; other site 1191061008498 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1191061008499 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1191061008500 eyelet of channel; other site 1191061008501 trimer interface [polypeptide binding]; other site 1191061008502 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1191061008503 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1191061008504 sequence-specific DNA binding site [nucleotide binding]; other site 1191061008505 salt bridge; other site 1191061008506 Cupin domain; Region: Cupin_2; pfam07883 1191061008507 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1191061008508 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1191061008509 NAD(P) binding site [chemical binding]; other site 1191061008510 substrate binding site [chemical binding]; other site 1191061008511 dimer interface [polypeptide binding]; other site 1191061008512 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1191061008513 active site 1191061008514 tetramer interface [polypeptide binding]; other site 1191061008515 hypothetical protein; Provisional; Region: PRK09981 1191061008516 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1191061008517 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1191061008518 N-terminal plug; other site 1191061008519 ligand-binding site [chemical binding]; other site 1191061008520 PQQ-like domain; Region: PQQ_2; pfam13360 1191061008521 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1191061008522 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1191061008523 L-asparagine permease; Provisional; Region: PRK15049 1191061008524 topology modulation protein; Provisional; Region: PRK07261 1191061008525 AAA domain; Region: AAA_17; pfam13207 1191061008526 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1191061008527 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1191061008528 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1191061008529 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1191061008530 metal binding site [ion binding]; metal-binding site 1191061008531 dimer interface [polypeptide binding]; other site 1191061008532 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1191061008533 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1191061008534 active site 1191061008535 non-prolyl cis peptide bond; other site 1191061008536 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1191061008537 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1191061008538 substrate binding pocket [chemical binding]; other site 1191061008539 membrane-bound complex binding site; other site 1191061008540 hinge residues; other site 1191061008541 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1191061008542 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1191061008543 Coenzyme A binding pocket [chemical binding]; other site 1191061008544 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061008545 dimer interface [polypeptide binding]; other site 1191061008546 conserved gate region; other site 1191061008547 putative PBP binding loops; other site 1191061008548 ABC-ATPase subunit interface; other site 1191061008549 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1191061008550 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1191061008551 Walker A/P-loop; other site 1191061008552 ATP binding site [chemical binding]; other site 1191061008553 Q-loop/lid; other site 1191061008554 ABC transporter signature motif; other site 1191061008555 Walker B; other site 1191061008556 D-loop; other site 1191061008557 H-loop/switch region; other site 1191061008558 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1191061008559 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1191061008560 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1191061008561 substrate binding pocket [chemical binding]; other site 1191061008562 membrane-bound complex binding site; other site 1191061008563 hinge residues; other site 1191061008564 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061008565 D-galactonate transporter; Region: 2A0114; TIGR00893 1191061008566 putative substrate translocation pore; other site 1191061008567 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1191061008568 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1191061008569 active site pocket [active] 1191061008570 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1191061008571 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1191061008572 DNA binding site [nucleotide binding] 1191061008573 domain linker motif; other site 1191061008574 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1191061008575 putative dimerization interface [polypeptide binding]; other site 1191061008576 putative ligand binding site [chemical binding]; other site 1191061008577 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1191061008578 C-terminal domain interface [polypeptide binding]; other site 1191061008579 GSH binding site (G-site) [chemical binding]; other site 1191061008580 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1191061008581 dimer interface [polypeptide binding]; other site 1191061008582 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1191061008583 N-terminal domain interface [polypeptide binding]; other site 1191061008584 dimer interface [polypeptide binding]; other site 1191061008585 substrate binding pocket (H-site) [chemical binding]; other site 1191061008586 4-oxalocrotonate tautomerase; Provisional; Region: PRK01271 1191061008587 active site 1 [active] 1191061008588 dimer interface [polypeptide binding]; other site 1191061008589 hexamer interface [polypeptide binding]; other site 1191061008590 active site 2 [active] 1191061008591 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 1191061008592 Predicted transcriptional regulator [Transcription]; Region: COG2944 1191061008593 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1191061008594 non-specific DNA binding site [nucleotide binding]; other site 1191061008595 salt bridge; other site 1191061008596 sequence-specific DNA binding site [nucleotide binding]; other site 1191061008597 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 1191061008598 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1191061008599 trimer interface; other site 1191061008600 sugar binding site [chemical binding]; other site 1191061008601 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061008602 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1191061008603 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 1191061008604 transcriptional activator RhaR; Provisional; Region: PRK13501 1191061008605 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1191061008606 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061008607 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1191061008608 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1191061008609 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1191061008610 Walker A/P-loop; other site 1191061008611 ATP binding site [chemical binding]; other site 1191061008612 Q-loop/lid; other site 1191061008613 ABC transporter signature motif; other site 1191061008614 Walker B; other site 1191061008615 D-loop; other site 1191061008616 H-loop/switch region; other site 1191061008617 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1191061008618 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1191061008619 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1191061008620 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061008621 dimer interface [polypeptide binding]; other site 1191061008622 conserved gate region; other site 1191061008623 putative PBP binding loops; other site 1191061008624 ABC-ATPase subunit interface; other site 1191061008625 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 1191061008626 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 1191061008627 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 1191061008628 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1191061008629 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1191061008630 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1191061008631 [4Fe-4S] binding site [ion binding]; other site 1191061008632 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1191061008633 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1191061008634 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1191061008635 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1191061008636 molybdopterin cofactor binding site; other site 1191061008637 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 1191061008638 TetR family transcriptional regulator; Provisional; Region: PRK14996 1191061008639 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1191061008640 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1191061008641 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061008642 putative substrate translocation pore; other site 1191061008643 aromatic amino acid exporter; Provisional; Region: PRK11689 1191061008644 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 1191061008645 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1191061008646 [4Fe-4S] binding site [ion binding]; other site 1191061008647 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1191061008648 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1191061008649 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1191061008650 molybdopterin cofactor binding site; other site 1191061008651 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1191061008652 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1191061008653 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 1191061008654 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1191061008655 MFS transport protein AraJ; Provisional; Region: PRK10091 1191061008656 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061008657 putative substrate translocation pore; other site 1191061008658 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 1191061008659 alkylhydroperoxidase domain protein, Avi_7169 family; Region: perox_Avi_7169; TIGR04030 1191061008660 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 1191061008661 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 1191061008662 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1191061008663 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1191061008664 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1191061008665 Walker A/P-loop; other site 1191061008666 ATP binding site [chemical binding]; other site 1191061008667 Q-loop/lid; other site 1191061008668 ABC transporter signature motif; other site 1191061008669 Walker B; other site 1191061008670 D-loop; other site 1191061008671 H-loop/switch region; other site 1191061008672 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1191061008673 Walker A/P-loop; other site 1191061008674 ATP binding site [chemical binding]; other site 1191061008675 Q-loop/lid; other site 1191061008676 ABC transporter signature motif; other site 1191061008677 Walker B; other site 1191061008678 D-loop; other site 1191061008679 H-loop/switch region; other site 1191061008680 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1191061008681 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1191061008682 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061008683 ABC-ATPase subunit interface; other site 1191061008684 putative PBP binding loops; other site 1191061008685 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1191061008686 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061008687 dimer interface [polypeptide binding]; other site 1191061008688 conserved gate region; other site 1191061008689 putative PBP binding loops; other site 1191061008690 ABC-ATPase subunit interface; other site 1191061008691 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1191061008692 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 1191061008693 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1191061008694 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1191061008695 NAD binding site [chemical binding]; other site 1191061008696 substrate binding site [chemical binding]; other site 1191061008697 catalytic Zn binding site [ion binding]; other site 1191061008698 tetramer interface [polypeptide binding]; other site 1191061008699 structural Zn binding site [ion binding]; other site 1191061008700 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1191061008701 dimer interface [polypeptide binding]; other site 1191061008702 substrate binding site [chemical binding]; other site 1191061008703 metal binding sites [ion binding]; metal-binding site 1191061008704 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1191061008705 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1191061008706 catalytic residues [active] 1191061008707 catalytic nucleophile [active] 1191061008708 Presynaptic Site I dimer interface [polypeptide binding]; other site 1191061008709 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1191061008710 Synaptic Flat tetramer interface [polypeptide binding]; other site 1191061008711 Synaptic Site I dimer interface [polypeptide binding]; other site 1191061008712 DNA binding site [nucleotide binding] 1191061008713 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1191061008714 DNA-binding interface [nucleotide binding]; DNA binding site 1191061008715 Protein of unknown function (DUF796); Region: DUF796; cl01226 1191061008716 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1191061008717 Coenzyme A binding pocket [chemical binding]; other site 1191061008718 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1191061008719 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1191061008720 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1191061008721 malate dehydrogenase; Provisional; Region: PRK13529 1191061008722 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1191061008723 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1191061008724 NAD(P) binding site [chemical binding]; other site 1191061008725 30S ribosomal protein subunit S22 family; Region: Ribosomal_S22; cl11579 1191061008726 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1191061008727 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061008728 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061008729 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1191061008730 putative effector binding pocket; other site 1191061008731 dimerization interface [polypeptide binding]; other site 1191061008732 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1191061008733 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1191061008734 Coenzyme A binding pocket [chemical binding]; other site 1191061008735 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 1191061008736 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1191061008737 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1191061008738 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1191061008739 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 1191061008740 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1191061008741 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1191061008742 putative molybdopterin cofactor binding site [chemical binding]; other site 1191061008743 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1191061008744 putative molybdopterin cofactor binding site; other site 1191061008745 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1191061008746 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1191061008747 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061008748 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1191061008749 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061008750 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061008751 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061008752 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1191061008753 dimerization interface [polypeptide binding]; other site 1191061008754 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061008755 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061008756 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1191061008757 putative effector binding pocket; other site 1191061008758 dimerization interface [polypeptide binding]; other site 1191061008759 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061008760 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1191061008761 putative substrate translocation pore; other site 1191061008762 benzoate transport; Region: 2A0115; TIGR00895 1191061008763 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061008764 putative substrate translocation pore; other site 1191061008765 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061008766 putative substrate translocation pore; other site 1191061008767 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 1191061008768 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1191061008769 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 1191061008770 heme binding site [chemical binding]; other site 1191061008771 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1191061008772 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061008773 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061008774 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1191061008775 putative effector binding pocket; other site 1191061008776 dimerization interface [polypeptide binding]; other site 1191061008777 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1191061008778 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1191061008779 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1191061008780 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1191061008781 B3/4 domain; Region: B3_4; pfam03483 1191061008782 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1191061008783 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1191061008784 non-specific DNA binding site [nucleotide binding]; other site 1191061008785 salt bridge; other site 1191061008786 sequence-specific DNA binding site [nucleotide binding]; other site 1191061008787 Cupin domain; Region: Cupin_2; pfam07883 1191061008788 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 1191061008789 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1191061008790 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1191061008791 VPS28 protein; Region: VPS28; pfam03997 1191061008792 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1191061008793 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1191061008794 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 1191061008795 Walker A/P-loop; other site 1191061008796 ATP binding site [chemical binding]; other site 1191061008797 Q-loop/lid; other site 1191061008798 ABC transporter signature motif; other site 1191061008799 Walker B; other site 1191061008800 D-loop; other site 1191061008801 H-loop/switch region; other site 1191061008802 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 1191061008803 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1191061008804 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1191061008805 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 1191061008806 urea carboxylase; Region: urea_carbox; TIGR02712 1191061008807 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1191061008808 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1191061008809 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1191061008810 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 1191061008811 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1191061008812 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1191061008813 carboxyltransferase (CT) interaction site; other site 1191061008814 biotinylation site [posttranslational modification]; other site 1191061008815 allophanate hydrolase; Provisional; Region: PRK08186 1191061008816 Amidase; Region: Amidase; cl11426 1191061008817 penicillin-binding protein 2; Provisional; Region: PRK10795 1191061008818 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1191061008819 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1191061008820 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1191061008821 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1191061008822 catalytic triad [active] 1191061008823 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1191061008824 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1191061008825 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1191061008826 NAD(P) binding site [chemical binding]; other site 1191061008827 active site 1191061008828 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1191061008829 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061008830 catalytic residue [active] 1191061008831 NMT1/THI5 like; Region: NMT1; pfam09084 1191061008832 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 1191061008833 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1191061008834 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061008835 dimer interface [polypeptide binding]; other site 1191061008836 conserved gate region; other site 1191061008837 ABC-ATPase subunit interface; other site 1191061008838 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 1191061008839 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1191061008840 Walker A/P-loop; other site 1191061008841 ATP binding site [chemical binding]; other site 1191061008842 Q-loop/lid; other site 1191061008843 ABC transporter signature motif; other site 1191061008844 Walker B; other site 1191061008845 D-loop; other site 1191061008846 H-loop/switch region; other site 1191061008847 Putative transcription activator [Transcription]; Region: TenA; COG0819 1191061008848 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1191061008849 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1191061008850 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1191061008851 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1191061008852 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1191061008853 DNA binding site [nucleotide binding] 1191061008854 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1191061008855 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1191061008856 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1191061008857 Secretory lipase; Region: LIP; pfam03583 1191061008858 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1191061008859 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1191061008860 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1191061008861 DNA binding residues [nucleotide binding] 1191061008862 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1191061008863 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1191061008864 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 1191061008865 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1191061008866 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1191061008867 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 1191061008868 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1191061008869 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1191061008870 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 1191061008871 C-lysozyme inhibitor; Provisional; Region: PRK09993 1191061008872 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 1191061008873 oxidoreductase; Provisional; Region: PRK06128 1191061008874 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1191061008875 NAD binding site [chemical binding]; other site 1191061008876 metal binding site [ion binding]; metal-binding site 1191061008877 active site 1191061008878 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1191061008879 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1191061008880 Coenzyme A binding pocket [chemical binding]; other site 1191061008881 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1191061008882 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1191061008883 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1191061008884 catalytic site [active] 1191061008885 active site 1191061008886 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1191061008887 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 1191061008888 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1191061008889 active site 1191061008890 catalytic site [active] 1191061008891 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1191061008892 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1191061008893 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1191061008894 active site 1191061008895 catalytic site [active] 1191061008896 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1191061008897 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1191061008898 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1191061008899 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1191061008900 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1191061008901 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 1191061008902 E3 interaction surface; other site 1191061008903 lipoyl attachment site [posttranslational modification]; other site 1191061008904 e3 binding domain; Region: E3_binding; pfam02817 1191061008905 e3 binding domain; Region: E3_binding; pfam02817 1191061008906 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1191061008907 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1191061008908 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1191061008909 alpha subunit interface [polypeptide binding]; other site 1191061008910 TPP binding site [chemical binding]; other site 1191061008911 heterodimer interface [polypeptide binding]; other site 1191061008912 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1191061008913 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 1191061008914 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1191061008915 tetramer interface [polypeptide binding]; other site 1191061008916 TPP-binding site [chemical binding]; other site 1191061008917 heterodimer interface [polypeptide binding]; other site 1191061008918 phosphorylation loop region [posttranslational modification] 1191061008919 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1191061008920 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1191061008921 DNA binding residues [nucleotide binding] 1191061008922 dimerization interface [polypeptide binding]; other site 1191061008923 Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406 1191061008924 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 1191061008925 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 1191061008926 nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889 1191061008927 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 1191061008928 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 1191061008929 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 1191061008930 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 1191061008931 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 1191061008932 amidase; Provisional; Region: PRK07235 1191061008933 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1191061008934 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1191061008935 heme-binding site [chemical binding]; other site 1191061008936 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 1191061008937 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 1191061008938 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1191061008939 Winged helix-turn helix; Region: HTH_29; pfam13551 1191061008940 Homeodomain-like domain; Region: HTH_32; pfam13565 1191061008941 SnoaL-like domain; Region: SnoaL_2; pfam12680 1191061008942 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 1191061008943 active site 1191061008944 antibiotic binding site [chemical binding]; other site 1191061008945 Phosphotransferase enzyme family; Region: APH; pfam01636 1191061008946 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 1191061008947 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1191061008948 non-specific DNA binding site [nucleotide binding]; other site 1191061008949 salt bridge; other site 1191061008950 sequence-specific DNA binding site [nucleotide binding]; other site 1191061008951 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1191061008952 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1191061008953 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1191061008954 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1191061008955 serine transporter; Region: stp; TIGR00814 1191061008956 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 1191061008957 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1191061008958 dimerization interface [polypeptide binding]; other site 1191061008959 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191061008960 dimer interface [polypeptide binding]; other site 1191061008961 phosphorylation site [posttranslational modification] 1191061008962 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191061008963 ATP binding site [chemical binding]; other site 1191061008964 Mg2+ binding site [ion binding]; other site 1191061008965 G-X-G motif; other site 1191061008966 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1191061008967 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1191061008968 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 1191061008969 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061008970 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061008971 salicylate synthase Irp9; Reviewed; Region: PRK06772 1191061008972 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1191061008973 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718 1191061008974 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1191061008975 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1191061008976 Walker A/P-loop; other site 1191061008977 ATP binding site [chemical binding]; other site 1191061008978 Q-loop/lid; other site 1191061008979 ABC transporter signature motif; other site 1191061008980 Walker B; other site 1191061008981 D-loop; other site 1191061008982 H-loop/switch region; other site 1191061008983 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1191061008984 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1191061008985 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1191061008986 Walker A/P-loop; other site 1191061008987 ATP binding site [chemical binding]; other site 1191061008988 Q-loop/lid; other site 1191061008989 ABC transporter signature motif; other site 1191061008990 Walker B; other site 1191061008991 D-loop; other site 1191061008992 H-loop/switch region; other site 1191061008993 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1191061008994 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061008995 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1191061008996 Condensation domain; Region: Condensation; pfam00668 1191061008997 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1191061008998 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1191061008999 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1191061009000 acyl-activating enzyme (AAE) consensus motif; other site 1191061009001 AMP binding site [chemical binding]; other site 1191061009002 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1191061009003 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1191061009004 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1191061009005 Condensation domain; Region: Condensation; pfam00668 1191061009006 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1191061009007 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1191061009008 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1191061009009 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1191061009010 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1191061009011 active site 1191061009012 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1191061009013 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1191061009014 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1191061009015 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1191061009016 KR domain; Region: KR; pfam08659 1191061009017 NADP binding site [chemical binding]; other site 1191061009018 active site 1191061009019 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1191061009020 Condensation domain; Region: Condensation; pfam00668 1191061009021 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1191061009022 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1191061009023 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1191061009024 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1191061009025 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1191061009026 Oxidoreductase (NAD-binding), involved in siderophore biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PchG; COG4693 1191061009027 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1191061009028 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1191061009029 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1191061009030 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1191061009031 acyl-activating enzyme (AAE) consensus motif; other site 1191061009032 active site 1191061009033 AMP binding site [chemical binding]; other site 1191061009034 substrate binding site [chemical binding]; other site 1191061009035 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1191061009036 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1191061009037 N-terminal plug; other site 1191061009038 ligand-binding site [chemical binding]; other site 1191061009039 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 1191061009040 BON domain; Region: BON; pfam04972 1191061009041 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1191061009042 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 1191061009043 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1191061009044 BtpA family; Region: BtpA; cl00440 1191061009045 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1191061009046 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1191061009047 substrate binding site [chemical binding]; other site 1191061009048 ATP binding site [chemical binding]; other site 1191061009049 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1191061009050 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1191061009051 ligand binding site [chemical binding]; other site 1191061009052 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1191061009053 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1191061009054 DNA binding site [nucleotide binding] 1191061009055 domain linker motif; other site 1191061009056 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_11; cd06293 1191061009057 putative dimerization interface [polypeptide binding]; other site 1191061009058 putative ligand binding site [chemical binding]; other site 1191061009059 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1191061009060 Walker A/P-loop; other site 1191061009061 ATP binding site [chemical binding]; other site 1191061009062 ABC transporter; Region: ABC_tran; pfam00005 1191061009063 Q-loop/lid; other site 1191061009064 ABC transporter signature motif; other site 1191061009065 Walker B; other site 1191061009066 D-loop; other site 1191061009067 H-loop/switch region; other site 1191061009068 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1191061009069 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1191061009070 TM-ABC transporter signature motif; other site 1191061009071 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1191061009072 active site 1191061009073 substrate binding pocket [chemical binding]; other site 1191061009074 homodimer interaction site [polypeptide binding]; other site 1191061009075 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1191061009076 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 1191061009077 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 1191061009078 metal binding site [ion binding]; metal-binding site 1191061009079 dimer interface [polypeptide binding]; other site 1191061009080 TolA C-terminal; Region: TolA; pfam06519 1191061009081 putative outer membrane receptor; Provisional; Region: PRK13513 1191061009082 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1191061009083 N-terminal plug; other site 1191061009084 ligand-binding site [chemical binding]; other site 1191061009085 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1191061009086 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1191061009087 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191061009088 active site 1191061009089 phosphorylation site [posttranslational modification] 1191061009090 intermolecular recognition site; other site 1191061009091 dimerization interface [polypeptide binding]; other site 1191061009092 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1191061009093 DNA binding residues [nucleotide binding] 1191061009094 dimerization interface [polypeptide binding]; other site 1191061009095 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1191061009096 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1191061009097 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191061009098 dimer interface [polypeptide binding]; other site 1191061009099 phosphorylation site [posttranslational modification] 1191061009100 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191061009101 ATP binding site [chemical binding]; other site 1191061009102 Mg2+ binding site [ion binding]; other site 1191061009103 G-X-G motif; other site 1191061009104 tetrathionate reductase subunit B; Provisional; Region: PRK14993 1191061009105 4Fe-4S binding domain; Region: Fer4; pfam00037 1191061009106 tetrathionate reductase subunit C; Provisional; Region: PRK14992 1191061009107 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 1191061009108 tetrathionate reductase subunit A; Provisional; Region: PRK14991 1191061009109 The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758 1191061009110 putative [Fe4-S4] binding site [ion binding]; other site 1191061009111 putative molybdopterin cofactor binding site [chemical binding]; other site 1191061009112 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 1191061009113 putative molybdopterin cofactor binding site; other site 1191061009114 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1191061009115 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1191061009116 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1191061009117 active site 1191061009118 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 1191061009119 Predicted transcriptional regulators [Transcription]; Region: COG1733 1191061009120 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1191061009121 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1191061009122 active site 1 [active] 1191061009123 dimer interface [polypeptide binding]; other site 1191061009124 hexamer interface [polypeptide binding]; other site 1191061009125 active site 2 [active] 1191061009126 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1191061009127 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191061009128 S-adenosylmethionine binding site [chemical binding]; other site 1191061009129 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061009130 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061009131 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1191061009132 putative effector binding pocket; other site 1191061009133 dimerization interface [polypeptide binding]; other site 1191061009134 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 1191061009135 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1191061009136 NAD(P) binding site [chemical binding]; other site 1191061009137 active site 1191061009138 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1191061009139 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1191061009140 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1191061009141 DNA-binding site [nucleotide binding]; DNA binding site 1191061009142 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1191061009143 hypothetical protein; Provisional; Region: PRK02947 1191061009144 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1191061009145 putative active site [active] 1191061009146 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 1191061009147 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1191061009148 active site 1191061009149 P-loop; other site 1191061009150 phosphorylation site [posttranslational modification] 1191061009151 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1191061009152 active site 1191061009153 phosphorylation site [posttranslational modification] 1191061009154 Creatinine amidohydrolase; Region: Creatininase; pfam02633 1191061009155 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1191061009156 active site 1191061009157 substrate binding pocket [chemical binding]; other site 1191061009158 homodimer interaction site [polypeptide binding]; other site 1191061009159 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1191061009160 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1191061009161 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1191061009162 hypothetical protein; Provisional; Region: PRK11415 1191061009163 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1191061009164 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1191061009165 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1191061009166 Uncharacterized conserved protein [Function unknown]; Region: COG4925 1191061009167 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1191061009168 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1191061009169 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1191061009170 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061009171 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061009172 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1191061009173 putative effector binding pocket; other site 1191061009174 putative dimerization interface [polypeptide binding]; other site 1191061009175 Dienelactone hydrolase family; Region: DLH; pfam01738 1191061009176 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 1191061009177 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1191061009178 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1191061009179 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1191061009180 conserved cys residue [active] 1191061009181 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 1191061009182 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1191061009183 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1191061009184 DNA binding site [nucleotide binding] 1191061009185 domain linker motif; other site 1191061009186 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1191061009187 ligand binding site [chemical binding]; other site 1191061009188 dimerization interface [polypeptide binding]; other site 1191061009189 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1191061009190 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 1191061009191 putative ligand binding site [chemical binding]; other site 1191061009192 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1191061009193 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1191061009194 Walker A/P-loop; other site 1191061009195 ATP binding site [chemical binding]; other site 1191061009196 Q-loop/lid; other site 1191061009197 ABC transporter signature motif; other site 1191061009198 Walker B; other site 1191061009199 D-loop; other site 1191061009200 H-loop/switch region; other site 1191061009201 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1191061009202 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1191061009203 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1191061009204 TM-ABC transporter signature motif; other site 1191061009205 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1191061009206 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1191061009207 putative substrate binding site [chemical binding]; other site 1191061009208 putative ATP binding site [chemical binding]; other site 1191061009209 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 1191061009210 Class I aldolases; Region: Aldolase_Class_I; cl17187 1191061009211 catalytic residue [active] 1191061009212 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 1191061009213 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1191061009214 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 1191061009215 putative N- and C-terminal domain interface [polypeptide binding]; other site 1191061009216 putative active site [active] 1191061009217 MgATP binding site [chemical binding]; other site 1191061009218 catalytic site [active] 1191061009219 metal binding site [ion binding]; metal-binding site 1191061009220 putative xylulose binding site [chemical binding]; other site 1191061009221 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1191061009222 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1191061009223 NAD(P) binding site [chemical binding]; other site 1191061009224 active site 1191061009225 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 1191061009226 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1191061009227 putative ligand binding site [chemical binding]; other site 1191061009228 putative NAD binding site [chemical binding]; other site 1191061009229 catalytic site [active] 1191061009230 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1191061009231 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1191061009232 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1191061009233 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1191061009234 trimer interface [polypeptide binding]; other site 1191061009235 eyelet of channel; other site 1191061009236 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 1191061009237 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1191061009238 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1191061009239 ABC-ATPase subunit interface; other site 1191061009240 dimer interface [polypeptide binding]; other site 1191061009241 putative PBP binding regions; other site 1191061009242 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 1191061009243 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1191061009244 putative ligand binding residues [chemical binding]; other site 1191061009245 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1191061009246 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1191061009247 Walker A/P-loop; other site 1191061009248 ATP binding site [chemical binding]; other site 1191061009249 Q-loop/lid; other site 1191061009250 ABC transporter signature motif; other site 1191061009251 Walker B; other site 1191061009252 D-loop; other site 1191061009253 H-loop/switch region; other site 1191061009254 NIPSNAP; Region: NIPSNAP; pfam07978 1191061009255 Winged helix-turn helix; Region: HTH_29; pfam13551 1191061009256 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1191061009257 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1191061009258 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 1191061009259 dimer interface [polypeptide binding]; other site 1191061009260 active site 1191061009261 catalytic nucleophile [active] 1191061009262 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 1191061009263 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1191061009264 interface (dimer of trimers) [polypeptide binding]; other site 1191061009265 Substrate-binding/catalytic site; other site 1191061009266 Zn-binding sites [ion binding]; other site 1191061009267 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061009268 putative substrate translocation pore; other site 1191061009269 Cupin; Region: Cupin_6; pfam12852 1191061009270 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1191061009271 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061009272 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1191061009273 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1191061009274 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 1191061009275 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 1191061009276 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1191061009277 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1191061009278 substrate binding pocket [chemical binding]; other site 1191061009279 membrane-bound complex binding site; other site 1191061009280 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061009281 dimer interface [polypeptide binding]; other site 1191061009282 conserved gate region; other site 1191061009283 putative PBP binding loops; other site 1191061009284 ABC-ATPase subunit interface; other site 1191061009285 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061009286 putative PBP binding loops; other site 1191061009287 dimer interface [polypeptide binding]; other site 1191061009288 ABC-ATPase subunit interface; other site 1191061009289 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1191061009290 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1191061009291 Walker A/P-loop; other site 1191061009292 ATP binding site [chemical binding]; other site 1191061009293 Q-loop/lid; other site 1191061009294 ABC transporter signature motif; other site 1191061009295 Walker B; other site 1191061009296 D-loop; other site 1191061009297 H-loop/switch region; other site 1191061009298 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 1191061009299 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 1191061009300 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1191061009301 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1191061009302 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1191061009303 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1191061009304 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1191061009305 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1191061009306 Walker A/P-loop; other site 1191061009307 ATP binding site [chemical binding]; other site 1191061009308 Q-loop/lid; other site 1191061009309 ABC transporter signature motif; other site 1191061009310 Walker B; other site 1191061009311 D-loop; other site 1191061009312 H-loop/switch region; other site 1191061009313 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061009314 dimer interface [polypeptide binding]; other site 1191061009315 conserved gate region; other site 1191061009316 ABC-ATPase subunit interface; other site 1191061009317 Nitronate monooxygenase; Region: NMO; pfam03060 1191061009318 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1191061009319 FMN binding site [chemical binding]; other site 1191061009320 substrate binding site [chemical binding]; other site 1191061009321 putative catalytic residue [active] 1191061009322 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061009323 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061009324 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1191061009325 dimerization interface [polypeptide binding]; other site 1191061009326 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061009327 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1191061009328 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1191061009329 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1191061009330 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1191061009331 active site 1191061009332 major facilitator superfamily transporter; Provisional; Region: PRK05122 1191061009333 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061009334 putative substrate translocation pore; other site 1191061009335 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1191061009336 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 1191061009337 HlyD family secretion protein; Region: HlyD_3; pfam13437 1191061009338 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 1191061009339 Outer membrane efflux protein; Region: OEP; pfam02321 1191061009340 Outer membrane efflux protein; Region: OEP; pfam02321 1191061009341 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 1191061009342 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 1191061009343 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 1191061009344 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191061009345 S-adenosylmethionine binding site [chemical binding]; other site 1191061009346 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1191061009347 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1191061009348 Coenzyme A binding pocket [chemical binding]; other site 1191061009349 altronate oxidoreductase; Provisional; Region: PRK03643 1191061009350 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1191061009351 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1191061009352 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1191061009353 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1191061009354 Coenzyme A binding pocket [chemical binding]; other site 1191061009355 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1191061009356 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1191061009357 metal binding site [ion binding]; metal-binding site 1191061009358 active site 1191061009359 I-site; other site 1191061009360 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 1191061009361 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1191061009362 glutaminase; Provisional; Region: PRK00971 1191061009363 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 1191061009364 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1191061009365 NAD(P) binding site [chemical binding]; other site 1191061009366 catalytic residues [active] 1191061009367 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1191061009368 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061009369 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1191061009370 putative dimerization interface [polypeptide binding]; other site 1191061009371 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1191061009372 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1191061009373 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1191061009374 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1191061009375 NAD binding site [chemical binding]; other site 1191061009376 dimer interface [polypeptide binding]; other site 1191061009377 substrate binding site [chemical binding]; other site 1191061009378 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1191061009379 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1191061009380 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1191061009381 4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371 1191061009382 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1191061009383 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1191061009384 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1191061009385 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1191061009386 active site 1191061009387 NAD binding site [chemical binding]; other site 1191061009388 metal binding site [ion binding]; metal-binding site 1191061009389 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1191061009390 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1191061009391 inhibitor site; inhibition site 1191061009392 active site 1191061009393 dimer interface [polypeptide binding]; other site 1191061009394 catalytic residue [active] 1191061009395 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1191061009396 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 1191061009397 BNR repeat-like domain; Region: BNR_2; pfam13088 1191061009398 Domain of unknown function (DUF386); Region: DUF386; cl01047 1191061009399 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1191061009400 transmembrane helices; other site 1191061009401 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1191061009402 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1191061009403 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1191061009404 putative arabinose transporter; Provisional; Region: PRK03545 1191061009405 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061009406 putative substrate translocation pore; other site 1191061009407 inner membrane protein; Provisional; Region: PRK10995 1191061009408 MarR family; Region: MarR_2; cl17246 1191061009409 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1191061009410 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 1191061009411 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061009412 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061009413 MarB protein; Region: MarB; pfam13999 1191061009414 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 1191061009415 EamA-like transporter family; Region: EamA; cl17759 1191061009416 putative transporter; Provisional; Region: PRK10054 1191061009417 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061009418 putative substrate translocation pore; other site 1191061009419 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1191061009420 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1191061009421 non-specific DNA binding site [nucleotide binding]; other site 1191061009422 salt bridge; other site 1191061009423 sequence-specific DNA binding site [nucleotide binding]; other site 1191061009424 2TM domain; Region: 2TM; pfam13239 1191061009425 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1191061009426 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1191061009427 Walker A/P-loop; other site 1191061009428 ATP binding site [chemical binding]; other site 1191061009429 Q-loop/lid; other site 1191061009430 ABC transporter signature motif; other site 1191061009431 Walker B; other site 1191061009432 D-loop; other site 1191061009433 H-loop/switch region; other site 1191061009434 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1191061009435 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1191061009436 Walker A/P-loop; other site 1191061009437 ATP binding site [chemical binding]; other site 1191061009438 Q-loop/lid; other site 1191061009439 ABC transporter signature motif; other site 1191061009440 Walker B; other site 1191061009441 D-loop; other site 1191061009442 H-loop/switch region; other site 1191061009443 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1191061009444 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1191061009445 TM-ABC transporter signature motif; other site 1191061009446 HEAT repeats; Region: HEAT_2; pfam13646 1191061009447 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1191061009448 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1191061009449 TM-ABC transporter signature motif; other site 1191061009450 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1191061009451 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 1191061009452 putative ligand binding site [chemical binding]; other site 1191061009453 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1191061009454 substrate binding site [chemical binding]; other site 1191061009455 THF binding site; other site 1191061009456 zinc-binding site [ion binding]; other site 1191061009457 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 1191061009458 active site residue [active] 1191061009459 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1191061009460 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1191061009461 conserved cys residue [active] 1191061009462 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061009463 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061009464 methionine synthase; Provisional; Region: PRK01207 1191061009465 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1191061009466 substrate binding site [chemical binding]; other site 1191061009467 THF binding site; other site 1191061009468 zinc-binding site [ion binding]; other site 1191061009469 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 1191061009470 anti-RssB factor; Provisional; Region: PRK10244 1191061009471 Sensors of blue-light using FAD; Region: BLUF; cl04855 1191061009472 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1191061009473 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1191061009474 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1191061009475 Coenzyme A binding pocket [chemical binding]; other site 1191061009476 lac repressor; Reviewed; Region: lacI; PRK09526 1191061009477 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1191061009478 DNA binding site [nucleotide binding] 1191061009479 domain linker motif; other site 1191061009480 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1191061009481 ligand binding site [chemical binding]; other site 1191061009482 dimerization interface (open form) [polypeptide binding]; other site 1191061009483 dimerization interface (closed form) [polypeptide binding]; other site 1191061009484 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 1191061009485 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1191061009486 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1191061009487 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1191061009488 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 1191061009489 Predicted ATPase [General function prediction only]; Region: COG4637 1191061009490 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1191061009491 Walker A/P-loop; other site 1191061009492 ATP binding site [chemical binding]; other site 1191061009493 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1191061009494 ABC transporter signature motif; other site 1191061009495 Walker B; other site 1191061009496 D-loop; other site 1191061009497 H-loop/switch region; other site 1191061009498 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 1191061009499 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 1191061009500 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1191061009501 DNA-binding site [nucleotide binding]; DNA binding site 1191061009502 RNA-binding motif; other site 1191061009503 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1191061009504 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 1191061009505 DNA binding residues [nucleotide binding] 1191061009506 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 1191061009507 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1191061009508 active site 1191061009509 Zn binding site [ion binding]; other site 1191061009510 malonic semialdehyde reductase; Provisional; Region: PRK10538 1191061009511 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 1191061009512 putative NAD(P) binding site [chemical binding]; other site 1191061009513 homodimer interface [polypeptide binding]; other site 1191061009514 homotetramer interface [polypeptide binding]; other site 1191061009515 active site 1191061009516 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1191061009517 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1191061009518 DNA-binding site [nucleotide binding]; DNA binding site 1191061009519 FCD domain; Region: FCD; pfam07729 1191061009520 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1191061009521 Ligand Binding Site [chemical binding]; other site 1191061009522 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1191061009523 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1191061009524 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1191061009525 metabolite-proton symporter; Region: 2A0106; TIGR00883 1191061009526 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061009527 putative substrate translocation pore; other site 1191061009528 putative oxidoreductase; Provisional; Region: PRK10083 1191061009529 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1191061009530 putative NAD(P) binding site [chemical binding]; other site 1191061009531 catalytic Zn binding site [ion binding]; other site 1191061009532 structural Zn binding site [ion binding]; other site 1191061009533 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 1191061009534 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 1191061009535 putative active site pocket [active] 1191061009536 putative metal binding site [ion binding]; other site 1191061009537 hypothetical protein; Provisional; Region: PRK02237 1191061009538 hypothetical protein; Provisional; Region: PRK13659 1191061009539 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 1191061009540 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1191061009541 Coenzyme A binding pocket [chemical binding]; other site 1191061009542 lipoprotein; Reviewed; Region: PRK02939 1191061009543 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 1191061009544 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1191061009545 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 1191061009546 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 1191061009547 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1191061009548 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1191061009549 Cl- selectivity filter; other site 1191061009550 Cl- binding residues [ion binding]; other site 1191061009551 pore gating glutamate residue; other site 1191061009552 dimer interface [polypeptide binding]; other site 1191061009553 putative dithiobiotin synthetase; Provisional; Region: PRK12374 1191061009554 AAA domain; Region: AAA_26; pfam13500 1191061009555 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1191061009556 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1191061009557 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1191061009558 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061009559 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061009560 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1191061009561 dimerization interface [polypeptide binding]; other site 1191061009562 substrate binding pocket [chemical binding]; other site 1191061009563 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1191061009564 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061009565 putative substrate translocation pore; other site 1191061009566 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 1191061009567 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 1191061009568 active site 1191061009569 Zn binding site [ion binding]; other site 1191061009570 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1191061009571 CHASE4 domain; Region: CHASE4; pfam05228 1191061009572 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1191061009573 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1191061009574 metal binding site [ion binding]; metal-binding site 1191061009575 active site 1191061009576 I-site; other site 1191061009577 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1191061009578 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 1191061009579 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 1191061009580 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 1191061009581 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1191061009582 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 1191061009583 Coenzyme A transferase; Region: CoA_trans; cl17247 1191061009584 triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237 1191061009585 malonate decarboxylase acyl carrier protein; Region: malonate_delta; TIGR03130 1191061009586 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 1191061009587 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; pfam06833 1191061009588 he Auxin Efflux Carrier (AEC) Family; Region: 2a69; TIGR00946 1191061009589 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293 1191061009590 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 1191061009591 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1191061009592 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 1191061009593 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061009594 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061009595 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1191061009596 dimerization interface [polypeptide binding]; other site 1191061009597 malate:quinone oxidoreductase; Validated; Region: PRK05257 1191061009598 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1191061009599 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1191061009600 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1191061009601 putative active site [active] 1191061009602 short chain dehydrogenase; Provisional; Region: PRK06500 1191061009603 classical (c) SDRs; Region: SDR_c; cd05233 1191061009604 NAD(P) binding site [chemical binding]; other site 1191061009605 active site 1191061009606 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061009607 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061009608 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1191061009609 putative effector binding pocket; other site 1191061009610 putative dimerization interface [polypeptide binding]; other site 1191061009611 sensory histidine kinase DcuS; Provisional; Region: PRK11086 1191061009612 PAS domain; Region: PAS; smart00091 1191061009613 putative active site [active] 1191061009614 heme pocket [chemical binding]; other site 1191061009615 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191061009616 ATP binding site [chemical binding]; other site 1191061009617 Mg2+ binding site [ion binding]; other site 1191061009618 G-X-G motif; other site 1191061009619 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 1191061009620 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191061009621 active site 1191061009622 phosphorylation site [posttranslational modification] 1191061009623 intermolecular recognition site; other site 1191061009624 dimerization interface [polypeptide binding]; other site 1191061009625 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1191061009626 ApbE family; Region: ApbE; pfam02424 1191061009627 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1191061009628 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1191061009629 putative active site [active] 1191061009630 putative FMN binding site [chemical binding]; other site 1191061009631 putative substrate binding site [chemical binding]; other site 1191061009632 putative catalytic residue [active] 1191061009633 FMN-binding domain; Region: FMN_bind; cl01081 1191061009634 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 1191061009635 L-aspartate oxidase; Provisional; Region: PRK06175 1191061009636 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1191061009637 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1191061009638 transmembrane helices; other site 1191061009639 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 1191061009640 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1191061009641 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 1191061009642 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 1191061009643 tetramer interface [polypeptide binding]; other site 1191061009644 active site 1191061009645 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 1191061009646 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1191061009647 dimer interface [polypeptide binding]; other site 1191061009648 active site 1191061009649 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1191061009650 3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429 1191061009651 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 1191061009652 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1191061009653 Bacterial transcriptional regulator; Region: IclR; pfam01614 1191061009654 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 1191061009655 Smr domain; Region: Smr; pfam01713 1191061009656 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 1191061009657 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061009658 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1191061009659 dimerization interface [polypeptide binding]; other site 1191061009660 M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665 1191061009661 amidohydrolase; Region: amidohydrolases; TIGR01891 1191061009662 putative metal binding site [ion binding]; other site 1191061009663 dimer interface [polypeptide binding]; other site 1191061009664 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 1191061009665 amidohydrolase; Region: amidohydrolases; TIGR01891 1191061009666 putative metal binding site [ion binding]; other site 1191061009667 putative aminobenzoyl-glutamate transporter; Provisional; Region: abgT; PRK11339 1191061009668 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 1191061009669 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 1191061009670 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1191061009671 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1191061009672 DNA binding site [nucleotide binding] 1191061009673 active site 1191061009674 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 1191061009675 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1191061009676 ligand binding site [chemical binding]; other site 1191061009677 flexible hinge region; other site 1191061009678 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1191061009679 putative switch regulator; other site 1191061009680 non-specific DNA interactions [nucleotide binding]; other site 1191061009681 DNA binding site [nucleotide binding] 1191061009682 sequence specific DNA binding site [nucleotide binding]; other site 1191061009683 putative cAMP binding site [chemical binding]; other site 1191061009684 universal stress protein UspE; Provisional; Region: PRK11175 1191061009685 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1191061009686 Ligand Binding Site [chemical binding]; other site 1191061009687 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1191061009688 Ligand Binding Site [chemical binding]; other site 1191061009689 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 1191061009690 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1191061009691 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 1191061009692 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1191061009693 ligand binding site [chemical binding]; other site 1191061009694 homodimer interface [polypeptide binding]; other site 1191061009695 NAD(P) binding site [chemical binding]; other site 1191061009696 trimer interface B [polypeptide binding]; other site 1191061009697 trimer interface A [polypeptide binding]; other site 1191061009698 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1191061009699 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1191061009700 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1191061009701 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1191061009702 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1191061009703 dihydromonapterin reductase; Provisional; Region: PRK06483 1191061009704 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1191061009705 NAD(P) binding site [chemical binding]; other site 1191061009706 active site 1191061009707 GlpM protein; Region: GlpM; pfam06942 1191061009708 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 1191061009709 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 1191061009710 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191061009711 active site 1191061009712 phosphorylation site [posttranslational modification] 1191061009713 intermolecular recognition site; other site 1191061009714 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1191061009715 DNA binding site [nucleotide binding] 1191061009716 GAF domain; Region: GAF; pfam01590 1191061009717 GAF domain; Region: GAF_2; pfam13185 1191061009718 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1191061009719 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1191061009720 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1191061009721 catalytic residues [active] 1191061009722 dimer interface [polypeptide binding]; other site 1191061009723 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1191061009724 sensor protein RstB; Provisional; Region: PRK10604 1191061009725 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1191061009726 dimerization interface [polypeptide binding]; other site 1191061009727 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191061009728 dimer interface [polypeptide binding]; other site 1191061009729 phosphorylation site [posttranslational modification] 1191061009730 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191061009731 ATP binding site [chemical binding]; other site 1191061009732 Mg2+ binding site [ion binding]; other site 1191061009733 G-X-G motif; other site 1191061009734 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 1191061009735 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1191061009736 Class II fumarases; Region: Fumarase_classII; cd01362 1191061009737 active site 1191061009738 tetramer interface [polypeptide binding]; other site 1191061009739 fumarate hydratase; Provisional; Region: PRK15389 1191061009740 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 1191061009741 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1191061009742 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1191061009743 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1191061009744 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1191061009745 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 1191061009746 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 1191061009747 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 1191061009748 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1191061009749 DNA binding site [nucleotide binding] 1191061009750 domain linker motif; other site 1191061009751 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1191061009752 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 1191061009753 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 1191061009754 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1191061009755 active site turn [active] 1191061009756 phosphorylation site [posttranslational modification] 1191061009757 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1191061009758 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1191061009759 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061009760 homodimer interface [polypeptide binding]; other site 1191061009761 catalytic residue [active] 1191061009762 YdfZ protein; Region: YdfZ; pfam14001 1191061009763 putative inner membrane protein; Provisional; Region: PRK11099 1191061009764 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 1191061009765 CPxP motif; other site 1191061009766 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 1191061009767 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 1191061009768 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1191061009769 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1191061009770 active site 1191061009771 purine riboside binding site [chemical binding]; other site 1191061009772 putative oxidoreductase; Provisional; Region: PRK11579 1191061009773 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1191061009774 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1191061009775 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1191061009776 beta-galactosidase; Region: BGL; TIGR03356 1191061009777 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 1191061009778 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 1191061009779 electron transport complex protein RsxA; Provisional; Region: PRK05151 1191061009780 ferredoxin; Provisional; Region: PRK08764 1191061009781 Putative Fe-S cluster; Region: FeS; cl17515 1191061009782 4Fe-4S binding domain; Region: Fer4; pfam00037 1191061009783 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 1191061009784 SLBB domain; Region: SLBB; pfam10531 1191061009785 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1191061009786 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 1191061009787 electron transport complex protein RnfG; Validated; Region: PRK01908 1191061009788 electron transport complex RsxE subunit; Provisional; Region: PRK12405 1191061009789 endonuclease III; Provisional; Region: PRK10702 1191061009790 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1191061009791 minor groove reading motif; other site 1191061009792 helix-hairpin-helix signature motif; other site 1191061009793 substrate binding pocket [chemical binding]; other site 1191061009794 active site 1191061009795 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1191061009796 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1191061009797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061009798 putative substrate translocation pore; other site 1191061009799 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061009800 putative substrate translocation pore; other site 1191061009801 glutathionine S-transferase; Provisional; Region: PRK10542 1191061009802 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1191061009803 C-terminal domain interface [polypeptide binding]; other site 1191061009804 GSH binding site (G-site) [chemical binding]; other site 1191061009805 dimer interface [polypeptide binding]; other site 1191061009806 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1191061009807 N-terminal domain interface [polypeptide binding]; other site 1191061009808 dimer interface [polypeptide binding]; other site 1191061009809 substrate binding pocket (H-site) [chemical binding]; other site 1191061009810 pyridoxamine kinase; Validated; Region: PRK05756 1191061009811 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1191061009812 dimer interface [polypeptide binding]; other site 1191061009813 pyridoxal binding site [chemical binding]; other site 1191061009814 ATP binding site [chemical binding]; other site 1191061009815 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1191061009816 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1191061009817 active site 1191061009818 HIGH motif; other site 1191061009819 dimer interface [polypeptide binding]; other site 1191061009820 KMSKS motif; other site 1191061009821 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1191061009822 RNA binding surface [nucleotide binding]; other site 1191061009823 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1191061009824 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1191061009825 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1191061009826 lysozyme inhibitor; Provisional; Region: PRK11372 1191061009827 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1191061009828 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1191061009829 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 1191061009830 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1191061009831 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1191061009832 metal binding site [ion binding]; metal-binding site 1191061009833 active site 1191061009834 I-site; other site 1191061009835 transcriptional regulator SlyA; Provisional; Region: PRK03573 1191061009836 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1191061009837 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 1191061009838 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1191061009839 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1191061009840 HlyD family secretion protein; Region: HlyD_3; pfam13437 1191061009841 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1191061009842 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1191061009843 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1191061009844 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1191061009845 E-class dimer interface [polypeptide binding]; other site 1191061009846 P-class dimer interface [polypeptide binding]; other site 1191061009847 active site 1191061009848 Cu2+ binding site [ion binding]; other site 1191061009849 Zn2+ binding site [ion binding]; other site 1191061009850 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1191061009851 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1191061009852 active site 1191061009853 catalytic tetrad [active] 1191061009854 Predicted Fe-S protein [General function prediction only]; Region: COG3313 1191061009855 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1191061009856 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1191061009857 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1191061009858 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1191061009859 FMN binding site [chemical binding]; other site 1191061009860 active site 1191061009861 substrate binding site [chemical binding]; other site 1191061009862 catalytic residue [active] 1191061009863 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1191061009864 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1191061009865 dimer interface [polypeptide binding]; other site 1191061009866 active site 1191061009867 metal binding site [ion binding]; metal-binding site 1191061009868 glutathione binding site [chemical binding]; other site 1191061009869 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1191061009870 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 1191061009871 dimer interface [polypeptide binding]; other site 1191061009872 catalytic site [active] 1191061009873 putative active site [active] 1191061009874 putative substrate binding site [chemical binding]; other site 1191061009875 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1191061009876 putative GSH binding site [chemical binding]; other site 1191061009877 catalytic residues [active] 1191061009878 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1191061009879 NlpC/P60 family; Region: NLPC_P60; pfam00877 1191061009880 superoxide dismutase; Provisional; Region: PRK10543 1191061009881 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1191061009882 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1191061009883 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061009884 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1191061009885 putative substrate translocation pore; other site 1191061009886 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 1191061009887 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1191061009888 DNA binding site [nucleotide binding] 1191061009889 domain linker motif; other site 1191061009890 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 1191061009891 dimerization interface [polypeptide binding]; other site 1191061009892 ligand binding site [chemical binding]; other site 1191061009893 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1191061009894 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061009895 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1191061009896 dimerization interface [polypeptide binding]; other site 1191061009897 putative transporter; Provisional; Region: PRK11043 1191061009898 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061009899 putative substrate translocation pore; other site 1191061009900 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 1191061009901 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191061009902 S-adenosylmethionine binding site [chemical binding]; other site 1191061009903 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 1191061009904 Lumazine binding domain; Region: Lum_binding; pfam00677 1191061009905 Lumazine binding domain; Region: Lum_binding; pfam00677 1191061009906 multidrug efflux protein; Reviewed; Region: PRK01766 1191061009907 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1191061009908 cation binding site [ion binding]; other site 1191061009909 General stress protein [General function prediction only]; Region: GsiB; COG3729 1191061009910 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 1191061009911 dimerization interface [polypeptide binding]; other site 1191061009912 metal binding site [ion binding]; metal-binding site 1191061009913 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1191061009914 dinuclear metal binding motif [ion binding]; other site 1191061009915 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1191061009916 dimanganese center [ion binding]; other site 1191061009917 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1191061009918 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1191061009919 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1191061009920 trehalose synthase; Region: treS_nterm; TIGR02456 1191061009921 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1191061009922 active site 1191061009923 catalytic site [active] 1191061009924 short chain dehydrogenase; Provisional; Region: PRK06181 1191061009925 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 1191061009926 putative NAD(P) binding site [chemical binding]; other site 1191061009927 active site 1191061009928 Competence-damaged protein; Region: CinA; cl00666 1191061009929 Predicted membrane protein [Function unknown]; Region: COG2323 1191061009930 hypothetical protein; Provisional; Region: PRK09897 1191061009931 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1191061009932 hypothetical protein; Provisional; Region: PRK10053 1191061009933 oxidoreductase; Provisional; Region: PRK06128 1191061009934 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1191061009935 NAD binding site [chemical binding]; other site 1191061009936 metal binding site [ion binding]; metal-binding site 1191061009937 active site 1191061009938 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1191061009939 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 1191061009940 active site clefts [active] 1191061009941 zinc binding site [ion binding]; other site 1191061009942 dimer interface [polypeptide binding]; other site 1191061009943 LysE type translocator; Region: LysE; cl00565 1191061009944 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1191061009945 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1191061009946 active site 1191061009947 metal binding site [ion binding]; metal-binding site 1191061009948 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 1191061009949 Chloramphenicol acetyltransferase; Region: CAT; cl02008 1191061009950 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1191061009951 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1191061009952 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1191061009953 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061009954 dimer interface [polypeptide binding]; other site 1191061009955 conserved gate region; other site 1191061009956 putative PBP binding loops; other site 1191061009957 ABC-ATPase subunit interface; other site 1191061009958 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1191061009959 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061009960 dimer interface [polypeptide binding]; other site 1191061009961 conserved gate region; other site 1191061009962 putative PBP binding loops; other site 1191061009963 ABC-ATPase subunit interface; other site 1191061009964 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1191061009965 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1191061009966 Walker A/P-loop; other site 1191061009967 ATP binding site [chemical binding]; other site 1191061009968 Q-loop/lid; other site 1191061009969 ABC transporter signature motif; other site 1191061009970 Walker B; other site 1191061009971 D-loop; other site 1191061009972 H-loop/switch region; other site 1191061009973 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1191061009974 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1191061009975 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1191061009976 Walker A/P-loop; other site 1191061009977 ATP binding site [chemical binding]; other site 1191061009978 Q-loop/lid; other site 1191061009979 ABC transporter signature motif; other site 1191061009980 Walker B; other site 1191061009981 D-loop; other site 1191061009982 H-loop/switch region; other site 1191061009983 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1191061009984 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1191061009985 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1191061009986 Trp docking motif [polypeptide binding]; other site 1191061009987 putative active site [active] 1191061009988 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1191061009989 active site 1191061009990 DNA binding site [nucleotide binding] 1191061009991 Int/Topo IB signature motif; other site 1191061009992 Fimbrial protein; Region: Fimbrial; cl01416 1191061009993 fimbrial assembly chaperone SthB; Provisional; Region: PRK15295 1191061009994 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1191061009995 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1191061009996 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1191061009997 PapC N-terminal domain; Region: PapC_N; pfam13954 1191061009998 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1191061009999 PapC C-terminal domain; Region: PapC_C; pfam13953 1191061010000 Fimbrial protein; Region: Fimbrial; pfam00419 1191061010001 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1191061010002 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1191061010003 active site 1191061010004 DNA binding site [nucleotide binding] 1191061010005 Int/Topo IB signature motif; other site 1191061010006 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 1191061010007 Protein of unknown function (DUF535); Region: DUF535; cl01128 1191061010008 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1191061010009 DNA-binding site [nucleotide binding]; DNA binding site 1191061010010 RNA-binding motif; other site 1191061010011 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061010012 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061010013 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 1191061010014 putative dimerization interface [polypeptide binding]; other site 1191061010015 putative substrate binding pocket [chemical binding]; other site 1191061010016 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 1191061010017 acetolactate synthase; Reviewed; Region: PRK08617 1191061010018 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1191061010019 PYR/PP interface [polypeptide binding]; other site 1191061010020 dimer interface [polypeptide binding]; other site 1191061010021 TPP binding site [chemical binding]; other site 1191061010022 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1191061010023 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1191061010024 TPP-binding site [chemical binding]; other site 1191061010025 dimer interface [polypeptide binding]; other site 1191061010026 acetoin reductase; Validated; Region: PRK08643 1191061010027 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 1191061010028 NAD binding site [chemical binding]; other site 1191061010029 homotetramer interface [polypeptide binding]; other site 1191061010030 homodimer interface [polypeptide binding]; other site 1191061010031 active site 1191061010032 substrate binding site [chemical binding]; other site 1191061010033 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1191061010034 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1191061010035 Walker A/P-loop; other site 1191061010036 ATP binding site [chemical binding]; other site 1191061010037 Q-loop/lid; other site 1191061010038 ABC transporter signature motif; other site 1191061010039 Walker B; other site 1191061010040 D-loop; other site 1191061010041 H-loop/switch region; other site 1191061010042 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1191061010043 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061010044 dimer interface [polypeptide binding]; other site 1191061010045 conserved gate region; other site 1191061010046 ABC-ATPase subunit interface; other site 1191061010047 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061010048 dimer interface [polypeptide binding]; other site 1191061010049 conserved gate region; other site 1191061010050 putative PBP binding loops; other site 1191061010051 ABC-ATPase subunit interface; other site 1191061010052 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1191061010053 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1191061010054 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 1191061010055 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 1191061010056 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1191061010057 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 1191061010058 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 1191061010059 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 1191061010060 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 1191061010061 Predicted ATPase involved in replication control, Cdc46/Mcm family [DNA replication, recombination, and repair]; Region: MCM2; COG1241 1191061010062 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 1191061010063 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1191061010064 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1191061010065 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 1191061010066 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 1191061010067 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1191061010068 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1191061010069 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 1191061010070 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1191061010071 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1191061010072 ligand binding site [chemical binding]; other site 1191061010073 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 1191061010074 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 1191061010075 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1191061010076 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 1191061010077 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1191061010078 Protein of unknown function (DUF770); Region: DUF770; pfam05591 1191061010079 putative dehydrogenase; Provisional; Region: PRK10098 1191061010080 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1191061010081 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1191061010082 [4Fe-4S] binding site [ion binding]; other site 1191061010083 molybdopterin cofactor binding site; other site 1191061010084 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 1191061010085 molybdopterin cofactor binding site; other site 1191061010086 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1191061010087 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1191061010088 metal binding site [ion binding]; metal-binding site 1191061010089 putative dimer interface [polypeptide binding]; other site 1191061010090 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061010091 putative substrate translocation pore; other site 1191061010092 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1191061010093 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1191061010094 Walker A/P-loop; other site 1191061010095 ATP binding site [chemical binding]; other site 1191061010096 Q-loop/lid; other site 1191061010097 ABC transporter signature motif; other site 1191061010098 Walker B; other site 1191061010099 D-loop; other site 1191061010100 H-loop/switch region; other site 1191061010101 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1191061010102 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061010103 dimer interface [polypeptide binding]; other site 1191061010104 conserved gate region; other site 1191061010105 putative PBP binding loops; other site 1191061010106 ABC-ATPase subunit interface; other site 1191061010107 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1191061010108 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1191061010109 substrate binding pocket [chemical binding]; other site 1191061010110 membrane-bound complex binding site; other site 1191061010111 hinge residues; other site 1191061010112 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1191061010113 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1191061010114 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1191061010115 putative active site [active] 1191061010116 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1191061010117 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1191061010118 siderophore binding site; other site 1191061010119 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1191061010120 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1191061010121 ABC-ATPase subunit interface; other site 1191061010122 dimer interface [polypeptide binding]; other site 1191061010123 putative PBP binding regions; other site 1191061010124 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1191061010125 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1191061010126 ABC-ATPase subunit interface; other site 1191061010127 dimer interface [polypeptide binding]; other site 1191061010128 putative PBP binding regions; other site 1191061010129 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1191061010130 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1191061010131 Walker A/P-loop; other site 1191061010132 ATP binding site [chemical binding]; other site 1191061010133 Q-loop/lid; other site 1191061010134 ABC transporter signature motif; other site 1191061010135 Walker B; other site 1191061010136 D-loop; other site 1191061010137 H-loop/switch region; other site 1191061010138 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1191061010139 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1191061010140 N-terminal plug; other site 1191061010141 ligand-binding site [chemical binding]; other site 1191061010142 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1191061010143 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1191061010144 Walker A/P-loop; other site 1191061010145 ATP binding site [chemical binding]; other site 1191061010146 Q-loop/lid; other site 1191061010147 ABC transporter signature motif; other site 1191061010148 Walker B; other site 1191061010149 D-loop; other site 1191061010150 H-loop/switch region; other site 1191061010151 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1191061010152 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061010153 dimer interface [polypeptide binding]; other site 1191061010154 conserved gate region; other site 1191061010155 putative PBP binding loops; other site 1191061010156 ABC-ATPase subunit interface; other site 1191061010157 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1191061010158 NMT1/THI5 like; Region: NMT1; pfam09084 1191061010159 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1191061010160 membrane-bound complex binding site; other site 1191061010161 hinge residues; other site 1191061010162 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1191061010163 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1191061010164 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1191061010165 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 1191061010166 dimer interface [polypeptide binding]; other site 1191061010167 active site 1191061010168 non-prolyl cis peptide bond; other site 1191061010169 insertion regions; other site 1191061010170 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061010171 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1191061010172 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 1191061010173 Member of the Rhodanese Homology Domain superfamily, repeat 1. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 1st repeat which does not contain the putative...; Region: 4RHOD_Repeat_1; cd01532 1191061010174 active site residue [active] 1191061010175 Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533 1191061010176 active site residue [active] 1191061010177 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 1191061010178 active site residue [active] 1191061010179 Member of the Rhodanese Homology Domain superfamily, repeat 4. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 4th repeat which, in general, contains the putative...; Region: 4RHOD_Repeat_4; cd01535 1191061010180 active site residue [active] 1191061010181 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 1191061010182 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1191061010183 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 1191061010184 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1191061010185 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1191061010186 active site 1191061010187 catalytic residues [active] 1191061010188 metal binding site [ion binding]; metal-binding site 1191061010189 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1191061010190 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1191061010191 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1191061010192 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1191061010193 2-keto-4-pentenoate hydratase; Provisional; Region: mhpD; PRK11342 1191061010194 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 1191061010195 S-formylglutathione hydrolase; Region: PLN02442 1191061010196 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 1191061010197 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1191061010198 putative active site [active] 1191061010199 Fe(II) binding site [ion binding]; other site 1191061010200 putative dimer interface [polypeptide binding]; other site 1191061010201 putative tetramer interface [polypeptide binding]; other site 1191061010202 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 1191061010203 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1191061010204 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 1191061010205 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1191061010206 Bacterial transcriptional regulator; Region: IclR; pfam01614 1191061010207 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 1191061010208 putative ligand binding residues [chemical binding]; other site 1191061010209 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1191061010210 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1191061010211 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1191061010212 ABC-ATPase subunit interface; other site 1191061010213 dimer interface [polypeptide binding]; other site 1191061010214 putative PBP binding regions; other site 1191061010215 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1191061010216 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1191061010217 Walker A/P-loop; other site 1191061010218 ATP binding site [chemical binding]; other site 1191061010219 Q-loop/lid; other site 1191061010220 ABC transporter signature motif; other site 1191061010221 Walker B; other site 1191061010222 D-loop; other site 1191061010223 H-loop/switch region; other site 1191061010224 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1191061010225 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1191061010226 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1191061010227 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1191061010228 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1191061010229 NAD(P) binding site [chemical binding]; other site 1191061010230 shikimate binding site; other site 1191061010231 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061010232 D-galactonate transporter; Region: 2A0114; TIGR00893 1191061010233 putative substrate translocation pore; other site 1191061010234 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1191061010235 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 1191061010236 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1191061010237 dimer interface [polypeptide binding]; other site 1191061010238 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1191061010239 active site 1191061010240 Fe binding site [ion binding]; other site 1191061010241 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 1191061010242 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1191061010243 hypothetical protein; Provisional; Region: PRK10292 1191061010244 pyruvate kinase; Provisional; Region: PRK09206 1191061010245 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 1191061010246 domain interfaces; other site 1191061010247 active site 1191061010248 murein lipoprotein; Provisional; Region: PRK15396 1191061010249 L,D-transpeptidase; Provisional; Region: PRK10260 1191061010250 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1191061010251 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1191061010252 cysteine desufuration protein SufE; Provisional; Region: PRK09296 1191061010253 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1191061010254 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1191061010255 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1191061010256 catalytic residue [active] 1191061010257 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 1191061010258 FeS assembly protein SufD; Region: sufD; TIGR01981 1191061010259 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 1191061010260 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1191061010261 Walker A/P-loop; other site 1191061010262 ATP binding site [chemical binding]; other site 1191061010263 Q-loop/lid; other site 1191061010264 ABC transporter signature motif; other site 1191061010265 Walker B; other site 1191061010266 D-loop; other site 1191061010267 H-loop/switch region; other site 1191061010268 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1191061010269 putative ABC transporter; Region: ycf24; CHL00085 1191061010270 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 1191061010271 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1191061010272 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 1191061010273 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1191061010274 PapC N-terminal domain; Region: PapC_N; pfam13954 1191061010275 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1191061010276 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1191061010277 PapC C-terminal domain; Region: PapC_C; pfam13953 1191061010278 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1191061010279 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1191061010280 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1191061010281 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1191061010282 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 1191061010283 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 1191061010284 ligand binding site [chemical binding]; other site 1191061010285 flexible hinge region; other site 1191061010286 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 1191061010287 hypothetical protein; Provisional; Region: PRK10457 1191061010288 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1191061010289 CoenzymeA binding site [chemical binding]; other site 1191061010290 subunit interaction site [polypeptide binding]; other site 1191061010291 PHB binding site; other site 1191061010292 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1191061010293 FAD binding domain; Region: FAD_binding_4; pfam01565 1191061010294 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1191061010295 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1191061010296 putative inner membrane protein; Provisional; Region: PRK10983 1191061010297 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1191061010298 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1191061010299 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1191061010300 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1191061010301 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1191061010302 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1191061010303 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 1191061010304 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1191061010305 Hemin uptake protein hemP; Region: hemP; cl10043 1191061010306 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1191061010307 hypothetical protein; Validated; Region: PRK00029 1191061010308 NlpC/P60 family; Region: NLPC_P60; pfam00877 1191061010309 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 1191061010310 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1191061010311 Walker A/P-loop; other site 1191061010312 ATP binding site [chemical binding]; other site 1191061010313 Q-loop/lid; other site 1191061010314 ABC transporter signature motif; other site 1191061010315 Walker B; other site 1191061010316 D-loop; other site 1191061010317 H-loop/switch region; other site 1191061010318 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1191061010319 catalytic residues [active] 1191061010320 dimer interface [polypeptide binding]; other site 1191061010321 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 1191061010322 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 1191061010323 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1191061010324 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1191061010325 ABC-ATPase subunit interface; other site 1191061010326 dimer interface [polypeptide binding]; other site 1191061010327 putative PBP binding regions; other site 1191061010328 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1191061010329 IHF dimer interface [polypeptide binding]; other site 1191061010330 IHF - DNA interface [nucleotide binding]; other site 1191061010331 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1191061010332 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1191061010333 putative tRNA-binding site [nucleotide binding]; other site 1191061010334 B3/4 domain; Region: B3_4; pfam03483 1191061010335 tRNA synthetase B5 domain; Region: B5; smart00874 1191061010336 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1191061010337 dimer interface [polypeptide binding]; other site 1191061010338 motif 1; other site 1191061010339 motif 3; other site 1191061010340 motif 2; other site 1191061010341 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1191061010342 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1191061010343 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1191061010344 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1191061010345 dimer interface [polypeptide binding]; other site 1191061010346 motif 1; other site 1191061010347 active site 1191061010348 motif 2; other site 1191061010349 motif 3; other site 1191061010350 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1191061010351 23S rRNA binding site [nucleotide binding]; other site 1191061010352 L21 binding site [polypeptide binding]; other site 1191061010353 L13 binding site [polypeptide binding]; other site 1191061010354 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1191061010355 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1191061010356 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1191061010357 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1191061010358 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1191061010359 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1191061010360 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1191061010361 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1191061010362 active site 1191061010363 dimer interface [polypeptide binding]; other site 1191061010364 motif 1; other site 1191061010365 motif 2; other site 1191061010366 motif 3; other site 1191061010367 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1191061010368 anticodon binding site; other site 1191061010369 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 1191061010370 6-phosphofructokinase 2; Provisional; Region: PRK10294 1191061010371 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1191061010372 putative substrate binding site [chemical binding]; other site 1191061010373 putative ATP binding site [chemical binding]; other site 1191061010374 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 1191061010375 Phosphotransferase enzyme family; Region: APH; pfam01636 1191061010376 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1191061010377 active site 1191061010378 ATP binding site [chemical binding]; other site 1191061010379 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1191061010380 transport protein TonB; Provisional; Region: PRK10819 1191061010381 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1191061010382 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1191061010383 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1191061010384 catalytic residues [active] 1191061010385 catalytic nucleophile [active] 1191061010386 Recombinase; Region: Recombinase; pfam07508 1191061010387 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1191061010388 Bacterial PH domain; Region: DUF304; pfam03703 1191061010389 YciI-like protein; Reviewed; Region: PRK11370 1191061010390 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1191061010391 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1191061010392 active site 1191061010393 FMN binding site [chemical binding]; other site 1191061010394 substrate binding site [chemical binding]; other site 1191061010395 homotetramer interface [polypeptide binding]; other site 1191061010396 catalytic residue [active] 1191061010397 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1191061010398 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1191061010399 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 1191061010400 putative active site [active] 1191061010401 catalytic site [active] 1191061010402 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 1191061010403 putative active site [active] 1191061010404 catalytic site [active] 1191061010405 dsDNA-mimic protein; Reviewed; Region: PRK05094 1191061010406 Ion transport protein; Region: Ion_trans; pfam00520 1191061010407 Ion channel; Region: Ion_trans_2; pfam07885 1191061010408 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1191061010409 Double zinc ribbon; Region: DZR; pfam12773 1191061010410 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 1191061010411 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1191061010412 Walker A/P-loop; other site 1191061010413 ATP binding site [chemical binding]; other site 1191061010414 Q-loop/lid; other site 1191061010415 ABC transporter signature motif; other site 1191061010416 Walker B; other site 1191061010417 D-loop; other site 1191061010418 H-loop/switch region; other site 1191061010419 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1191061010420 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 1191061010421 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1191061010422 Walker A/P-loop; other site 1191061010423 ATP binding site [chemical binding]; other site 1191061010424 Q-loop/lid; other site 1191061010425 ABC transporter signature motif; other site 1191061010426 Walker B; other site 1191061010427 D-loop; other site 1191061010428 H-loop/switch region; other site 1191061010429 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1191061010430 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 1191061010431 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1191061010432 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061010433 dimer interface [polypeptide binding]; other site 1191061010434 conserved gate region; other site 1191061010435 ABC-ATPase subunit interface; other site 1191061010436 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1191061010437 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061010438 dimer interface [polypeptide binding]; other site 1191061010439 conserved gate region; other site 1191061010440 putative PBP binding loops; other site 1191061010441 ABC-ATPase subunit interface; other site 1191061010442 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1191061010443 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1191061010444 peptide binding site [polypeptide binding]; other site 1191061010445 hypothetical protein; Provisional; Region: PRK11111 1191061010446 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1191061010447 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1191061010448 putative catalytic cysteine [active] 1191061010449 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1191061010450 putative active site [active] 1191061010451 metal binding site [ion binding]; metal-binding site 1191061010452 thymidine kinase; Provisional; Region: PRK04296 1191061010453 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 1191061010454 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1191061010455 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1191061010456 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1191061010457 active site 1191061010458 tetramer interface; other site 1191061010459 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191061010460 active site 1191061010461 response regulator of RpoS; Provisional; Region: PRK10693 1191061010462 phosphorylation site [posttranslational modification] 1191061010463 intermolecular recognition site; other site 1191061010464 dimerization interface [polypeptide binding]; other site 1191061010465 hypothetical protein; Provisional; Region: PRK10279 1191061010466 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1191061010467 nucleophile elbow; other site 1191061010468 hypothetical protein; Provisional; Region: PRK01617 1191061010469 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1191061010470 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1191061010471 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1191061010472 putative active site [active] 1191061010473 putative substrate binding site [chemical binding]; other site 1191061010474 putative cosubstrate binding site; other site 1191061010475 catalytic site [active] 1191061010476 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 1191061010477 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1191061010478 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1191061010479 4Fe-4S binding domain; Region: Fer4; cl02805 1191061010480 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 1191061010481 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1191061010482 [4Fe-4S] binding site [ion binding]; other site 1191061010483 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1191061010484 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1191061010485 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1191061010486 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1191061010487 molybdopterin cofactor binding site; other site 1191061010488 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 1191061010489 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 1191061010490 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1191061010491 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1191061010492 dimerization interface [polypeptide binding]; other site 1191061010493 Histidine kinase; Region: HisKA_3; pfam07730 1191061010494 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191061010495 ATP binding site [chemical binding]; other site 1191061010496 Mg2+ binding site [ion binding]; other site 1191061010497 G-X-G motif; other site 1191061010498 transcriptional regulator NarL; Provisional; Region: PRK10651 1191061010499 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191061010500 active site 1191061010501 phosphorylation site [posttranslational modification] 1191061010502 intermolecular recognition site; other site 1191061010503 dimerization interface [polypeptide binding]; other site 1191061010504 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1191061010505 DNA binding residues [nucleotide binding] 1191061010506 dimerization interface [polypeptide binding]; other site 1191061010507 putative invasin; Provisional; Region: PRK10177 1191061010508 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1191061010509 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1191061010510 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1191061010511 [4Fe-4S] binding site [ion binding]; other site 1191061010512 molybdopterin cofactor binding site; other site 1191061010513 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1191061010514 molybdopterin cofactor binding site; other site 1191061010515 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1191061010516 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1191061010517 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1191061010518 nitrite reductase subunit NirD; Provisional; Region: PRK14989 1191061010519 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1191061010520 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1191061010521 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1191061010522 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1191061010523 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1191061010524 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1191061010525 Walker A/P-loop; other site 1191061010526 ATP binding site [chemical binding]; other site 1191061010527 Q-loop/lid; other site 1191061010528 ABC transporter signature motif; other site 1191061010529 Walker B; other site 1191061010530 D-loop; other site 1191061010531 H-loop/switch region; other site 1191061010532 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1191061010533 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061010534 dimer interface [polypeptide binding]; other site 1191061010535 conserved gate region; other site 1191061010536 putative PBP binding loops; other site 1191061010537 ABC-ATPase subunit interface; other site 1191061010538 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1191061010539 NMT1-like family; Region: NMT1_2; pfam13379 1191061010540 Nitrate and nitrite sensing; Region: NIT; pfam08376 1191061010541 ANTAR domain; Region: ANTAR; pfam03861 1191061010542 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 1191061010543 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 1191061010544 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 1191061010545 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1191061010546 putative active site pocket [active] 1191061010547 dimerization interface [polypeptide binding]; other site 1191061010548 putative catalytic residue [active] 1191061010549 cation transport regulator; Reviewed; Region: chaB; PRK09582 1191061010550 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 1191061010551 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1191061010552 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1191061010553 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1191061010554 hypothetical protein; Provisional; Region: PRK10941 1191061010555 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 1191061010556 Zona pellucida-like domain; Region: Zona_pellucida; cl02523 1191061010557 Invasion gene expression up-regulator, SirB; Region: SirB; cl01184 1191061010558 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1191061010559 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191061010560 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1191061010561 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1191061010562 RF-1 domain; Region: RF-1; pfam00472 1191061010563 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1191061010564 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1191061010565 tRNA; other site 1191061010566 putative tRNA binding site [nucleotide binding]; other site 1191061010567 putative NADP binding site [chemical binding]; other site 1191061010568 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1191061010569 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 1191061010570 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 1191061010571 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 1191061010572 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1191061010573 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1191061010574 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1191061010575 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1191061010576 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1191061010577 active site 1191061010578 putative transporter; Provisional; Region: PRK11660 1191061010579 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1191061010580 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1191061010581 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1191061010582 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 1191061010583 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1191061010584 DNA binding residues [nucleotide binding] 1191061010585 putative dimer interface [polypeptide binding]; other site 1191061010586 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1191061010587 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1191061010588 hypothetical protein; Provisional; Region: PRK10692 1191061010589 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1191061010590 putative active site [active] 1191061010591 catalytic residue [active] 1191061010592 GTP-binding protein YchF; Reviewed; Region: PRK09601 1191061010593 YchF GTPase; Region: YchF; cd01900 1191061010594 G1 box; other site 1191061010595 GTP/Mg2+ binding site [chemical binding]; other site 1191061010596 Switch I region; other site 1191061010597 G2 box; other site 1191061010598 Switch II region; other site 1191061010599 G3 box; other site 1191061010600 G4 box; other site 1191061010601 G5 box; other site 1191061010602 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1191061010603 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1191061010604 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1191061010605 active site 1191061010606 Int/Topo IB signature motif; other site 1191061010607 mobile mystery protein B; Region: mob_myst_B; TIGR02613 1191061010608 Fic/DOC family; Region: Fic; pfam02661 1191061010609 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 1191061010610 PAS domain; Region: PAS; smart00091 1191061010611 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191061010612 Walker A motif; other site 1191061010613 ATP binding site [chemical binding]; other site 1191061010614 Walker B motif; other site 1191061010615 arginine finger; other site 1191061010616 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1191061010617 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 1191061010618 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1191061010619 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1191061010620 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1191061010621 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 1191061010622 catalytic residue [active] 1191061010623 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1191061010624 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1191061010625 peptidase; Reviewed; Region: PRK13004 1191061010626 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 1191061010627 putative metal binding site [ion binding]; other site 1191061010628 putative dimer interface [polypeptide binding]; other site 1191061010629 phenylhydantoinase; Validated; Region: PRK08323 1191061010630 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 1191061010631 tetramer interface [polypeptide binding]; other site 1191061010632 active site 1191061010633 carbamate kinase; Reviewed; Region: PRK12686 1191061010634 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1191061010635 putative substrate binding site [chemical binding]; other site 1191061010636 homodimer interface [polypeptide binding]; other site 1191061010637 nucleotide binding site [chemical binding]; other site 1191061010638 nucleotide binding site [chemical binding]; other site 1191061010639 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1191061010640 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1191061010641 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 1191061010642 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1191061010643 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1191061010644 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1191061010645 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 1191061010646 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1191061010647 active site 1191061010648 putative substrate binding pocket [chemical binding]; other site 1191061010649 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 1191061010650 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12809 1191061010651 4Fe-4S binding domain; Region: Fer4; pfam00037 1191061010652 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1191061010653 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1191061010654 xanthine permease; Region: pbuX; TIGR03173 1191061010655 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1191061010656 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1191061010657 [4Fe-4S] binding site [ion binding]; other site 1191061010658 molybdopterin cofactor binding site; other site 1191061010659 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 1191061010660 molybdopterin cofactor binding site; other site 1191061010661 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1191061010662 Ligand binding site; other site 1191061010663 metal-binding site 1191061010664 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1191061010665 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1191061010666 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1191061010667 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1191061010668 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1191061010669 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1191061010670 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 1191061010671 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1191061010672 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061010673 putative substrate translocation pore; other site 1191061010674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061010675 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1191061010676 active site 1191061010677 phosphorylation site [posttranslational modification] 1191061010678 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1191061010679 active site 1191061010680 homotetramer interface [polypeptide binding]; other site 1191061010681 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 1191061010682 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1191061010683 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1191061010684 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1191061010685 active site 1191061010686 substrate-binding site [chemical binding]; other site 1191061010687 metal-binding site [ion binding] 1191061010688 ATP binding site [chemical binding]; other site 1191061010689 cell density-dependent motility repressor; Provisional; Region: PRK10082 1191061010690 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061010691 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1191061010692 dimerization interface [polypeptide binding]; other site 1191061010693 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1191061010694 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1191061010695 active site 1191061010696 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1191061010697 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1191061010698 Walker A/P-loop; other site 1191061010699 ATP binding site [chemical binding]; other site 1191061010700 Q-loop/lid; other site 1191061010701 ABC transporter signature motif; other site 1191061010702 Walker B; other site 1191061010703 D-loop; other site 1191061010704 H-loop/switch region; other site 1191061010705 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1191061010706 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061010707 dimer interface [polypeptide binding]; other site 1191061010708 conserved gate region; other site 1191061010709 ABC-ATPase subunit interface; other site 1191061010710 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1191061010711 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1191061010712 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1191061010713 active site 1191061010714 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1191061010715 non-prolyl cis peptide bond; other site 1191061010716 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 1191061010717 Fatty acid desaturase protein family subgroup, a delta-12 acyl-lipid desaturase-like, DesA-like, yet uncharacterized subgroup of membrane fatty acid desaturase proteins found in alpha-, beta-, and gamma-proteobacteria. Sequences of this domain family...; Region: DesA_FADS-like; cd03509 1191061010718 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1191061010719 putative di-iron ligands [ion binding]; other site 1191061010720 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1191061010721 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061010722 putative substrate translocation pore; other site 1191061010723 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061010724 Helix-turn-helix domain; Region: HTH_18; pfam12833 1191061010725 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1191061010726 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1191061010727 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1191061010728 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1191061010729 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1191061010730 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1191061010731 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1191061010732 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1191061010733 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1191061010734 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1191061010735 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1191061010736 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1191061010737 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1191061010738 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 1191061010739 putative symporter YagG; Provisional; Region: PRK09669 1191061010740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061010741 putative substrate translocation pore; other site 1191061010742 Trehalase; Region: Trehalase; cl17346 1191061010743 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 1191061010744 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 1191061010745 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1191061010746 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1191061010747 catalytic residue [active] 1191061010748 DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is...; Region: DEP; cl02442 1191061010749 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1191061010750 dimer interface [polypeptide binding]; other site 1191061010751 catalytic triad [active] 1191061010752 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 1191061010753 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1191061010754 TrkA-C domain; Region: TrkA_C; pfam02080 1191061010755 Transporter associated domain; Region: CorC_HlyC; smart01091 1191061010756 alanine racemase; Reviewed; Region: dadX; PRK03646 1191061010757 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1191061010758 active site 1191061010759 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1191061010760 substrate binding site [chemical binding]; other site 1191061010761 catalytic residues [active] 1191061010762 dimer interface [polypeptide binding]; other site 1191061010763 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1191061010764 SpoVR family protein; Provisional; Region: PRK11767 1191061010765 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1191061010766 fatty acid metabolism regulator; Provisional; Region: PRK04984 1191061010767 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1191061010768 DNA-binding site [nucleotide binding]; DNA binding site 1191061010769 FadR C-terminal domain; Region: FadR_C; pfam07840 1191061010770 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 1191061010771 disulfide bond formation protein B; Provisional; Region: PRK01749 1191061010772 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 1191061010773 hypothetical protein; Provisional; Region: PRK05170 1191061010774 hypothetical protein; Provisional; Region: PRK10691 1191061010775 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1191061010776 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 1191061010777 septum formation inhibitor; Reviewed; Region: minC; PRK03511 1191061010778 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 1191061010779 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1191061010780 cell division inhibitor MinD; Provisional; Region: PRK10818 1191061010781 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1191061010782 Switch I; other site 1191061010783 Switch II; other site 1191061010784 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 1191061010785 ribonuclease D; Provisional; Region: PRK10829 1191061010786 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1191061010787 catalytic site [active] 1191061010788 putative active site [active] 1191061010789 putative substrate binding site [chemical binding]; other site 1191061010790 Helicase and RNase D C-terminal; Region: HRDC; smart00341 1191061010791 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 1191061010792 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1191061010793 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1191061010794 acyl-activating enzyme (AAE) consensus motif; other site 1191061010795 putative AMP binding site [chemical binding]; other site 1191061010796 putative active site [active] 1191061010797 putative CoA binding site [chemical binding]; other site 1191061010798 Outer membrane lipoprotein Slp family; Region: Slp; cl01164 1191061010799 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 1191061010800 Glycoprotease family; Region: Peptidase_M22; pfam00814 1191061010801 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1191061010802 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1191061010803 DEAD_2; Region: DEAD_2; pfam06733 1191061010804 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1191061010805 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1191061010806 homotrimer interaction site [polypeptide binding]; other site 1191061010807 putative active site [active] 1191061010808 Alginate lyase; Region: Alginate_lyase; pfam05426 1191061010809 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1191061010810 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1191061010811 Walker A/P-loop; other site 1191061010812 ATP binding site [chemical binding]; other site 1191061010813 Q-loop/lid; other site 1191061010814 ABC transporter signature motif; other site 1191061010815 Walker B; other site 1191061010816 D-loop; other site 1191061010817 H-loop/switch region; other site 1191061010818 TOBE domain; Region: TOBE_2; pfam08402 1191061010819 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1191061010820 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061010821 dimer interface [polypeptide binding]; other site 1191061010822 conserved gate region; other site 1191061010823 putative PBP binding loops; other site 1191061010824 ABC-ATPase subunit interface; other site 1191061010825 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1191061010826 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061010827 dimer interface [polypeptide binding]; other site 1191061010828 conserved gate region; other site 1191061010829 putative PBP binding loops; other site 1191061010830 ABC-ATPase subunit interface; other site 1191061010831 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1191061010832 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1191061010833 Alginate lyase; Region: Alginate_lyase; pfam05426 1191061010834 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 1191061010835 hypothetical protein; Provisional; Region: PRK05114 1191061010836 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 1191061010837 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1191061010838 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1191061010839 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1191061010840 putative active site [active] 1191061010841 putative CoA binding site [chemical binding]; other site 1191061010842 nudix motif; other site 1191061010843 metal binding site [ion binding]; metal-binding site 1191061010844 L-serine deaminase; Provisional; Region: PRK15023 1191061010845 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1191061010846 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1191061010847 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1191061010848 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1191061010849 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1191061010850 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1191061010851 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1191061010852 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1191061010853 Transporter associated domain; Region: CorC_HlyC; smart01091 1191061010854 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 1191061010855 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1191061010856 active pocket/dimerization site; other site 1191061010857 active site 1191061010858 phosphorylation site [posttranslational modification] 1191061010859 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1191061010860 active site 1191061010861 phosphorylation site [posttranslational modification] 1191061010862 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1191061010863 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 1191061010864 hypothetical protein; Provisional; Region: PRK02913 1191061010865 hypothetical protein; Provisional; Region: PRK11469 1191061010866 Domain of unknown function DUF; Region: DUF204; pfam02659 1191061010867 Domain of unknown function DUF; Region: DUF204; pfam02659 1191061010868 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1191061010869 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191061010870 S-adenosylmethionine binding site [chemical binding]; other site 1191061010871 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 1191061010872 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1191061010873 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1191061010874 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1191061010875 DNA-binding site [nucleotide binding]; DNA binding site 1191061010876 RNA-binding motif; other site 1191061010877 YebO-like protein; Region: YebO; pfam13974 1191061010878 PhoPQ regulatory protein; Provisional; Region: PRK10299 1191061010879 YobH-like protein; Region: YobH; pfam13996 1191061010880 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 1191061010881 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1191061010882 dimerization interface [polypeptide binding]; other site 1191061010883 putative Zn2+ binding site [ion binding]; other site 1191061010884 putative DNA binding site [nucleotide binding]; other site 1191061010885 Bacterial transcriptional regulator; Region: IclR; pfam01614 1191061010886 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061010887 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1191061010888 putative substrate translocation pore; other site 1191061010889 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061010890 heat shock protein HtpX; Provisional; Region: PRK05457 1191061010891 carboxy-terminal protease; Provisional; Region: PRK11186 1191061010892 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1191061010893 protein binding site [polypeptide binding]; other site 1191061010894 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1191061010895 Catalytic dyad [active] 1191061010896 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 1191061010897 ProP expression regulator; Provisional; Region: PRK04950 1191061010898 ProQ/FINO family; Region: ProQ; pfam04352 1191061010899 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1191061010900 GAF domain; Region: GAF_2; pfam13185 1191061010901 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 1191061010902 Paraquat-inducible protein A; Region: PqiA; pfam04403 1191061010903 Paraquat-inducible protein A; Region: PqiA; pfam04403 1191061010904 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 1191061010905 mce related protein; Region: MCE; pfam02470 1191061010906 mce related protein; Region: MCE; pfam02470 1191061010907 mce related protein; Region: MCE; pfam02470 1191061010908 mce related protein; Region: MCE; pfam02470 1191061010909 mce related protein; Region: MCE; pfam02470 1191061010910 mce related protein; Region: MCE; pfam02470 1191061010911 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 1191061010912 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191061010913 S-adenosylmethionine binding site [chemical binding]; other site 1191061010914 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 1191061010915 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 1191061010916 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 1191061010917 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 1191061010918 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1191061010919 Protein of unknown function (DUF535); Region: DUF535; pfam04393 1191061010920 Spore Coat Protein U domain; Region: SCPU; pfam05229 1191061010921 Spore Coat Protein U domain; Region: SCPU; pfam05229 1191061010922 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1191061010923 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1191061010924 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1191061010925 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1191061010926 PapC C-terminal domain; Region: PapC_C; pfam13953 1191061010927 Spore Coat Protein U domain; Region: SCPU; pfam05229 1191061010928 Spore Coat Protein U domain; Region: SCPU; pfam05229 1191061010929 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 1191061010930 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1191061010931 CopC domain; Region: CopC; cl01012 1191061010932 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 1191061010933 exodeoxyribonuclease X; Provisional; Region: PRK07983 1191061010934 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1191061010935 active site 1191061010936 catalytic site [active] 1191061010937 substrate binding site [chemical binding]; other site 1191061010938 protease 2; Provisional; Region: PRK10115 1191061010939 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1191061010940 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 1191061010941 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 1191061010942 putative metal binding site [ion binding]; other site 1191061010943 YebG protein; Region: YebG; pfam07130 1191061010944 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1191061010945 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1191061010946 ATP-grasp domain; Region: ATP-grasp; pfam02222 1191061010947 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1191061010948 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1191061010949 active site 1191061010950 intersubunit interface [polypeptide binding]; other site 1191061010951 catalytic residue [active] 1191061010952 phosphogluconate dehydratase; Validated; Region: PRK09054 1191061010953 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1191061010954 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1191061010955 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1191061010956 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1191061010957 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 1191061010958 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1191061010959 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1191061010960 putative active site [active] 1191061010961 pyruvate kinase; Provisional; Region: PRK05826 1191061010962 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1191061010963 domain interfaces; other site 1191061010964 active site 1191061010965 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 1191061010966 Predicted permeases [General function prediction only]; Region: COG0679 1191061010967 malate dehydrogenase; Provisional; Region: PRK13529 1191061010968 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1191061010969 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1191061010970 NAD(P) binding site [chemical binding]; other site 1191061010971 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 1191061010972 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191061010973 active site 1191061010974 phosphorylation site [posttranslational modification] 1191061010975 intermolecular recognition site; other site 1191061010976 dimerization interface [polypeptide binding]; other site 1191061010977 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1191061010978 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1191061010979 putative acyl-acceptor binding pocket; other site 1191061010980 putative peptidase; Provisional; Region: PRK11649 1191061010981 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 1191061010982 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1191061010983 Peptidase family M23; Region: Peptidase_M23; pfam01551 1191061010984 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 1191061010985 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 1191061010986 metal binding site [ion binding]; metal-binding site 1191061010987 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 1191061010988 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1191061010989 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1191061010990 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1191061010991 ABC-ATPase subunit interface; other site 1191061010992 dimer interface [polypeptide binding]; other site 1191061010993 putative PBP binding regions; other site 1191061010994 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1191061010995 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191061010996 Walker A motif; other site 1191061010997 ATP binding site [chemical binding]; other site 1191061010998 Walker B motif; other site 1191061010999 arginine finger; other site 1191061011000 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1191061011001 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1191061011002 RuvA N terminal domain; Region: RuvA_N; pfam01330 1191061011003 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1191061011004 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1191061011005 active site 1191061011006 putative DNA-binding cleft [nucleotide binding]; other site 1191061011007 dimer interface [polypeptide binding]; other site 1191061011008 hypothetical protein; Validated; Region: PRK00110 1191061011009 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 1191061011010 nudix motif; other site 1191061011011 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1191061011012 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1191061011013 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1191061011014 homodimer interface [polypeptide binding]; other site 1191061011015 motif 1; other site 1191061011016 active site 1191061011017 motif 2; other site 1191061011018 GAD domain; Region: GAD; pfam02938 1191061011019 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1191061011020 active site 1191061011021 motif 3; other site 1191061011022 Isochorismatase family; Region: Isochorismatase; pfam00857 1191061011023 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1191061011024 catalytic triad [active] 1191061011025 conserved cis-peptide bond; other site 1191061011026 hypothetical protein; Provisional; Region: PRK10302 1191061011027 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 1191061011028 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191061011029 S-adenosylmethionine binding site [chemical binding]; other site 1191061011030 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1191061011031 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191061011032 S-adenosylmethionine binding site [chemical binding]; other site 1191061011033 copper homeostasis protein CutC; Provisional; Region: PRK11572 1191061011034 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 1191061011035 putative metal binding site [ion binding]; other site 1191061011036 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1191061011037 arginyl-tRNA synthetase; Region: argS; TIGR00456 1191061011038 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1191061011039 active site 1191061011040 HIGH motif; other site 1191061011041 KMSK motif region; other site 1191061011042 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1191061011043 tRNA binding surface [nucleotide binding]; other site 1191061011044 anticodon binding site; other site 1191061011045 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1191061011046 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1191061011047 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061011048 putative substrate translocation pore; other site 1191061011049 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1191061011050 Ligand Binding Site [chemical binding]; other site 1191061011051 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 1191061011052 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1191061011053 active site 1191061011054 homotetramer interface [polypeptide binding]; other site 1191061011055 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1191061011056 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1191061011057 active site 1191061011058 motif I; other site 1191061011059 motif II; other site 1191061011060 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1191061011061 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1191061011062 TM-ABC transporter signature motif; other site 1191061011063 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 1191061011064 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1191061011065 Walker A/P-loop; other site 1191061011066 ATP binding site [chemical binding]; other site 1191061011067 Q-loop/lid; other site 1191061011068 ABC transporter signature motif; other site 1191061011069 Walker B; other site 1191061011070 D-loop; other site 1191061011071 H-loop/switch region; other site 1191061011072 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1191061011073 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 1191061011074 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 1191061011075 ligand binding site [chemical binding]; other site 1191061011076 DJ-1 family protein; Region: not_thiJ; TIGR01383 1191061011077 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1191061011078 conserved cys residue [active] 1191061011079 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1191061011080 Ferritin-like domain; Region: Ferritin; pfam00210 1191061011081 ferroxidase diiron center [ion binding]; other site 1191061011082 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1191061011083 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061011084 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 1191061011085 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061011086 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1191061011087 putative substrate translocation pore; other site 1191061011088 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061011089 hypothetical protein; Provisional; Region: PRK09273 1191061011090 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 1191061011091 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 1191061011092 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1191061011093 Ferritin-like domain; Region: Ferritin; pfam00210 1191061011094 ferroxidase diiron center [ion binding]; other site 1191061011095 probable metal-binding protein; Region: matur_matur; TIGR03853 1191061011096 tyrosine transporter TyrP; Provisional; Region: PRK15132 1191061011097 aromatic amino acid transport protein; Region: araaP; TIGR00837 1191061011098 hypothetical protein; Provisional; Region: PRK10396 1191061011099 yecA family protein; Region: ygfB_yecA; TIGR02292 1191061011100 SEC-C motif; Region: SEC-C; pfam02810 1191061011101 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1191061011102 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1191061011103 inhibitor site; inhibition site 1191061011104 active site 1191061011105 dimer interface [polypeptide binding]; other site 1191061011106 catalytic residue [active] 1191061011107 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 1191061011108 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1191061011109 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1191061011110 GIY-YIG motif/motif A; other site 1191061011111 active site 1191061011112 catalytic site [active] 1191061011113 putative DNA binding site [nucleotide binding]; other site 1191061011114 metal binding site [ion binding]; metal-binding site 1191061011115 UvrB/uvrC motif; Region: UVR; pfam02151 1191061011116 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1191061011117 response regulator; Provisional; Region: PRK09483 1191061011118 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191061011119 active site 1191061011120 phosphorylation site [posttranslational modification] 1191061011121 intermolecular recognition site; other site 1191061011122 dimerization interface [polypeptide binding]; other site 1191061011123 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1191061011124 DNA binding residues [nucleotide binding] 1191061011125 dimerization interface [polypeptide binding]; other site 1191061011126 hypothetical protein; Provisional; Region: PRK10613 1191061011127 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 1191061011128 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1191061011129 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1191061011130 DNA binding residues [nucleotide binding] 1191061011131 dimerization interface [polypeptide binding]; other site 1191061011132 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 1191061011133 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1191061011134 Walker A/P-loop; other site 1191061011135 ATP binding site [chemical binding]; other site 1191061011136 Q-loop/lid; other site 1191061011137 ABC transporter signature motif; other site 1191061011138 Walker B; other site 1191061011139 D-loop; other site 1191061011140 H-loop/switch region; other site 1191061011141 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1191061011142 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061011143 dimer interface [polypeptide binding]; other site 1191061011144 conserved gate region; other site 1191061011145 putative PBP binding loops; other site 1191061011146 ABC-ATPase subunit interface; other site 1191061011147 D-cysteine desulfhydrase; Validated; Region: PRK03910 1191061011148 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 1191061011149 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061011150 catalytic residue [active] 1191061011151 cystine transporter subunit; Provisional; Region: PRK11260 1191061011152 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1191061011153 substrate binding pocket [chemical binding]; other site 1191061011154 membrane-bound complex binding site; other site 1191061011155 hinge residues; other site 1191061011156 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 1191061011157 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 1191061011158 active site 1191061011159 Na/Ca binding site [ion binding]; other site 1191061011160 catalytic site [active] 1191061011161 lipoprotein; Provisional; Region: PRK10397 1191061011162 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 1191061011163 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1191061011164 DNA binding residues [nucleotide binding] 1191061011165 dimerization interface [polypeptide binding]; other site 1191061011166 hypothetical protein; Provisional; Region: PRK10708 1191061011167 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 1191061011168 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 1191061011169 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 1191061011170 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1191061011171 metal binding site [ion binding]; metal-binding site 1191061011172 active site 1191061011173 I-site; other site 1191061011174 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 1191061011175 hypothetical protein; Provisional; Region: PRK10062 1191061011176 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1191061011177 EamA-like transporter family; Region: EamA; pfam00892 1191061011178 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 1191061011179 additional DNA contacts [nucleotide binding]; other site 1191061011180 mismatch recognition site; other site 1191061011181 active site 1191061011182 zinc binding site [ion binding]; other site 1191061011183 DNA intercalation site [nucleotide binding]; other site 1191061011184 DNA cytosine methylase; Provisional; Region: PRK10458 1191061011185 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1191061011186 cofactor binding site; other site 1191061011187 DNA binding site [nucleotide binding] 1191061011188 substrate interaction site [chemical binding]; other site 1191061011189 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1191061011190 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1191061011191 Zn2+ binding site [ion binding]; other site 1191061011192 Mg2+ binding site [ion binding]; other site 1191061011193 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 1191061011194 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1191061011195 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1191061011196 trimer interface [polypeptide binding]; other site 1191061011197 eyelet of channel; other site 1191061011198 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1191061011199 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1191061011200 Ligand binding site; other site 1191061011201 Putative Catalytic site; other site 1191061011202 DXD motif; other site 1191061011203 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 1191061011204 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1191061011205 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1191061011206 NAD(P) binding site [chemical binding]; other site 1191061011207 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 1191061011208 homotrimer interaction site [polypeptide binding]; other site 1191061011209 putative active site [active] 1191061011210 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061011211 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061011212 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1191061011213 putative effector binding pocket; other site 1191061011214 putative dimerization interface [polypeptide binding]; other site 1191061011215 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061011216 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061011217 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1191061011218 putative effector binding pocket; other site 1191061011219 putative dimerization interface [polypeptide binding]; other site 1191061011220 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1191061011221 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1191061011222 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1191061011223 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1191061011224 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1191061011225 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1191061011226 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1191061011227 motif I; other site 1191061011228 motif II; other site 1191061011229 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1191061011230 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1191061011231 Ligand Binding Site [chemical binding]; other site 1191061011232 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1191061011233 HlyD family secretion protein; Region: HlyD_3; pfam13437 1191061011234 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1191061011235 Protein export membrane protein; Region: SecD_SecF; cl14618 1191061011236 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1191061011237 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 1191061011238 Uncharacterized membrane protein [Function unknown]; Region: SpmB; cl17667 1191061011239 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1191061011240 Polymyxin resistance protein PmrD; Region: PmrD; cl12732 1191061011241 AMP nucleosidase; Provisional; Region: PRK08292 1191061011242 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 1191061011243 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1191061011244 MATE family multidrug exporter; Provisional; Region: PRK10189 1191061011245 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 1191061011246 potential frameshift: common BLAST hit: gi|375261655|ref|YP_005020825.1| integrase family protein 1191061011247 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1191061011248 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1191061011249 active site 1191061011250 DNA binding site [nucleotide binding] 1191061011251 Int/Topo IB signature motif; other site 1191061011252 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1191061011253 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 1191061011254 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1191061011255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061011256 putative substrate translocation pore; other site 1191061011257 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061011258 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1191061011259 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1191061011260 active site 1191061011261 catalytic tetrad [active] 1191061011262 GH3 auxin-responsive promoter; Region: GH3; pfam03321 1191061011263 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1191061011264 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1191061011265 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1191061011266 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1191061011267 metal binding site [ion binding]; metal-binding site 1191061011268 substrate binding pocket [chemical binding]; other site 1191061011269 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1191061011270 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1191061011271 PYR/PP interface [polypeptide binding]; other site 1191061011272 dimer interface [polypeptide binding]; other site 1191061011273 TPP binding site [chemical binding]; other site 1191061011274 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1191061011275 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1191061011276 TPP-binding site [chemical binding]; other site 1191061011277 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 1191061011278 short chain dehydrogenase; Provisional; Region: PRK07041 1191061011279 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1191061011280 NAD(P) binding site [chemical binding]; other site 1191061011281 active site 1191061011282 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 1191061011283 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 1191061011284 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 1191061011285 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 1191061011286 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 1191061011287 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1191061011288 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061011289 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061011290 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1191061011291 putative effector binding pocket; other site 1191061011292 putative dimerization interface [polypeptide binding]; other site 1191061011293 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1191061011294 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1191061011295 active site 1191061011296 catalytic tetrad [active] 1191061011297 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1191061011298 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061011299 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1191061011300 dimerization interface [polypeptide binding]; other site 1191061011301 substrate binding pocket [chemical binding]; other site 1191061011302 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1191061011303 C-terminal domain interface [polypeptide binding]; other site 1191061011304 GSH binding site (G-site) [chemical binding]; other site 1191061011305 maleylacetoacetate isomerase; Region: maiA; TIGR01262 1191061011306 dimer interface [polypeptide binding]; other site 1191061011307 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1191061011308 N-terminal domain interface [polypeptide binding]; other site 1191061011309 dimer interface [polypeptide binding]; other site 1191061011310 substrate binding pocket (H-site) [chemical binding]; other site 1191061011311 L,D-transpeptidase; Provisional; Region: PRK10190 1191061011312 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1191061011313 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 1191061011314 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1191061011315 dimerization interface [polypeptide binding]; other site 1191061011316 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 1191061011317 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061011318 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 1191061011319 putative dimerization interface [polypeptide binding]; other site 1191061011320 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1191061011321 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1191061011322 DNA binding residues [nucleotide binding] 1191061011323 dimerization interface [polypeptide binding]; other site 1191061011324 Fimbrial protein; Region: Fimbrial; cl01416 1191061011325 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1191061011326 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1191061011327 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1191061011328 outer membrane usher protein; Provisional; Region: PRK15193 1191061011329 PapC N-terminal domain; Region: PapC_N; pfam13954 1191061011330 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1191061011331 PapC C-terminal domain; Region: PapC_C; pfam13953 1191061011332 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1191061011333 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1191061011334 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 1191061011335 mannosyl binding site [chemical binding]; other site 1191061011336 Fimbrial protein; Region: Fimbrial; cl01416 1191061011337 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1191061011338 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1191061011339 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 1191061011340 NAD binding site [chemical binding]; other site 1191061011341 sugar binding site [chemical binding]; other site 1191061011342 divalent metal binding site [ion binding]; other site 1191061011343 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1191061011344 dimer interface [polypeptide binding]; other site 1191061011345 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 1191061011346 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1191061011347 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1191061011348 active site turn [active] 1191061011349 phosphorylation site [posttranslational modification] 1191061011350 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1191061011351 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1191061011352 DNA-binding site [nucleotide binding]; DNA binding site 1191061011353 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1191061011354 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 1191061011355 Domain of unknown function (DUF1971); Region: DUF1971; cl17717 1191061011356 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1191061011357 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1191061011358 metal binding site [ion binding]; metal-binding site 1191061011359 active site 1191061011360 I-site; other site 1191061011361 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1191061011362 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1191061011363 shikimate transporter; Provisional; Region: PRK09952 1191061011364 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061011365 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061011366 putative substrate translocation pore; other site 1191061011367 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1191061011368 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061011369 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061011370 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1191061011371 putative effector binding pocket; other site 1191061011372 dimerization interface [polypeptide binding]; other site 1191061011373 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1191061011374 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1191061011375 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1191061011376 DNA binding site [nucleotide binding] 1191061011377 domain linker motif; other site 1191061011378 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 1191061011379 putative dimerization interface [polypeptide binding]; other site 1191061011380 putative ligand binding site [chemical binding]; other site 1191061011381 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1191061011382 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1191061011383 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1191061011384 active site 1191061011385 phosphorylation site [posttranslational modification] 1191061011386 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1191061011387 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1191061011388 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1191061011389 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1191061011390 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061011391 putative substrate translocation pore; other site 1191061011392 HPP family; Region: HPP; pfam04982 1191061011393 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1191061011394 NAD binding site [chemical binding]; other site 1191061011395 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1191061011396 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363 1191061011397 hypothetical protein; Provisional; Region: PRK05423 1191061011398 Predicted membrane protein [Function unknown]; Region: COG1289 1191061011399 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1191061011400 DNA gyrase inhibitor; Provisional; Region: PRK10016 1191061011401 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 1191061011402 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 1191061011403 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1191061011404 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1191061011405 exonuclease I; Provisional; Region: sbcB; PRK11779 1191061011406 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 1191061011407 active site 1191061011408 catalytic site [active] 1191061011409 substrate binding site [chemical binding]; other site 1191061011410 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 1191061011411 elongation factor G; Reviewed; Region: PRK00007 1191061011412 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1191061011413 G1 box; other site 1191061011414 putative GEF interaction site [polypeptide binding]; other site 1191061011415 GTP/Mg2+ binding site [chemical binding]; other site 1191061011416 Switch I region; other site 1191061011417 G2 box; other site 1191061011418 G3 box; other site 1191061011419 Switch II region; other site 1191061011420 G4 box; other site 1191061011421 G5 box; other site 1191061011422 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1191061011423 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1191061011424 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1191061011425 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1191061011426 dimerization interface [polypeptide binding]; other site 1191061011427 putative DNA binding site [nucleotide binding]; other site 1191061011428 putative Zn2+ binding site [ion binding]; other site 1191061011429 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1191061011430 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1191061011431 dimer interface [polypeptide binding]; other site 1191061011432 PYR/PP interface [polypeptide binding]; other site 1191061011433 TPP binding site [chemical binding]; other site 1191061011434 substrate binding site [chemical binding]; other site 1191061011435 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1191061011436 Domain of unknown function; Region: EKR; pfam10371 1191061011437 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1191061011438 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 1191061011439 TPP-binding site [chemical binding]; other site 1191061011440 dimer interface [polypeptide binding]; other site 1191061011441 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 1191061011442 nitrogenase iron protein; Region: nifH; TIGR01287 1191061011443 Nucleotide-binding sites [chemical binding]; other site 1191061011444 Walker A motif; other site 1191061011445 Switch I region of nucleotide binding site; other site 1191061011446 Fe4S4 binding sites [ion binding]; other site 1191061011447 Switch II region of nucleotide binding site; other site 1191061011448 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 1191061011449 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 1191061011450 MoFe protein alpha/beta subunit interactions; other site 1191061011451 Alpha subunit P cluster binding residues; other site 1191061011452 FeMoco binding residues [chemical binding]; other site 1191061011453 MoFe protein alpha subunit/Fe protein contacts; other site 1191061011454 MoFe protein dimer/ dimer interactions; other site 1191061011455 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 1191061011456 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 1191061011457 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 1191061011458 MoFe protein beta/alpha subunit interactions; other site 1191061011459 Beta subunit P cluster binding residues; other site 1191061011460 MoFe protein beta subunit/Fe protein contacts; other site 1191061011461 MoFe protein dimer/ dimer interactions; other site 1191061011462 NifT/FixU protein; Region: NifT; pfam06988 1191061011463 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 1191061011464 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 1191061011465 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 1191061011466 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 1191061011467 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 1191061011468 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 1191061011469 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 1191061011470 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1191061011471 trimerization site [polypeptide binding]; other site 1191061011472 active site 1191061011473 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1191061011474 NifU-like domain; Region: NifU; pfam01106 1191061011475 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1191061011476 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1191061011477 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1191061011478 catalytic residue [active] 1191061011479 potential frameshift: common BLAST hit: gi|375261778|ref|YP_005020948.1| homocitrate synthase 1191061011480 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1191061011481 catalytic residues [active] 1191061011482 homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660 1191061011483 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1191061011484 active site 1191061011485 metal binding site [ion binding]; metal-binding site 1191061011486 Nitrogen fixation protein NifW; Region: NifW; cl03935 1191061011487 NifZ domain; Region: NifZ; pfam04319 1191061011488 nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933 1191061011489 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1191061011490 flavodoxin FldA; Validated; Region: PRK09267 1191061011491 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 1191061011492 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191061011493 putative active site [active] 1191061011494 heme pocket [chemical binding]; other site 1191061011495 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191061011496 ATP binding site [chemical binding]; other site 1191061011497 G-X-G motif; other site 1191061011498 Nif-specific regulatory protein; Region: nifA; TIGR01817 1191061011499 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1191061011500 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191061011501 Walker A motif; other site 1191061011502 ATP binding site [chemical binding]; other site 1191061011503 Walker B motif; other site 1191061011504 arginine finger; other site 1191061011505 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1191061011506 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 1191061011507 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1191061011508 FeS/SAM binding site; other site 1191061011509 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 1191061011510 NifQ; Region: NifQ; pfam04891 1191061011511 amino acid transporter; Region: 2A0306; TIGR00909 1191061011512 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061011513 transcriptional regulator, ArgP family; Region: argP; TIGR03298 1191061011514 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1191061011515 dimerization interface [polypeptide binding]; other site 1191061011516 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1191061011517 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 1191061011518 putative NAD(P) binding site [chemical binding]; other site 1191061011519 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1191061011520 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1191061011521 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1191061011522 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1191061011523 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1191061011524 NAD binding site [chemical binding]; other site 1191061011525 dimerization interface [polypeptide binding]; other site 1191061011526 product binding site; other site 1191061011527 substrate binding site [chemical binding]; other site 1191061011528 zinc binding site [ion binding]; other site 1191061011529 catalytic residues [active] 1191061011530 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 1191061011531 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1191061011532 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061011533 homodimer interface [polypeptide binding]; other site 1191061011534 catalytic residue [active] 1191061011535 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 1191061011536 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1191061011537 active site 1191061011538 motif I; other site 1191061011539 motif II; other site 1191061011540 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1191061011541 putative active site pocket [active] 1191061011542 4-fold oligomerization interface [polypeptide binding]; other site 1191061011543 metal binding residues [ion binding]; metal-binding site 1191061011544 3-fold/trimer interface [polypeptide binding]; other site 1191061011545 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 1191061011546 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1191061011547 putative active site [active] 1191061011548 oxyanion strand; other site 1191061011549 catalytic triad [active] 1191061011550 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1191061011551 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1191061011552 catalytic residues [active] 1191061011553 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1191061011554 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1191061011555 substrate binding site [chemical binding]; other site 1191061011556 glutamase interaction surface [polypeptide binding]; other site 1191061011557 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1191061011558 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1191061011559 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1191061011560 metal binding site [ion binding]; metal-binding site 1191061011561 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1191061011562 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1191061011563 active site 1191061011564 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1191061011565 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1191061011566 putative ADP-binding pocket [chemical binding]; other site 1191061011567 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1191061011568 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1191061011569 active site 1191061011570 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1191061011571 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1191061011572 UDP-galactopyranose mutase; Region: GLF; pfam03275 1191061011573 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 1191061011574 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1191061011575 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1191061011576 Ligand binding site; other site 1191061011577 metal-binding site 1191061011578 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1191061011579 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1191061011580 Walker A/P-loop; other site 1191061011581 ATP binding site [chemical binding]; other site 1191061011582 Q-loop/lid; other site 1191061011583 ABC transporter signature motif; other site 1191061011584 Walker B; other site 1191061011585 D-loop; other site 1191061011586 H-loop/switch region; other site 1191061011587 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1191061011588 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1191061011589 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 1191061011590 putative NAD(P) binding site [chemical binding]; other site 1191061011591 active site 1191061011592 putative substrate binding site [chemical binding]; other site 1191061011593 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 1191061011594 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1191061011595 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1191061011596 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1191061011597 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1191061011598 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987 1191061011599 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1191061011600 NADP binding site [chemical binding]; other site 1191061011601 active site 1191061011602 putative substrate binding site [chemical binding]; other site 1191061011603 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1191061011604 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1191061011605 substrate binding site; other site 1191061011606 tetramer interface; other site 1191061011607 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1191061011608 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1191061011609 NAD binding site [chemical binding]; other site 1191061011610 substrate binding site [chemical binding]; other site 1191061011611 homodimer interface [polypeptide binding]; other site 1191061011612 active site 1191061011613 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1191061011614 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1191061011615 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1191061011616 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1191061011617 colanic acid exporter; Provisional; Region: PRK10459 1191061011618 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1191061011619 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1191061011620 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1191061011621 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1191061011622 active site 1191061011623 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 1191061011624 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1191061011625 tyrosine kinase; Provisional; Region: PRK11519 1191061011626 Chain length determinant protein; Region: Wzz; pfam02706 1191061011627 Chain length determinant protein; Region: Wzz; cl15801 1191061011628 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1191061011629 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1191061011630 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1191061011631 polysaccharide export protein Wza; Provisional; Region: PRK15078 1191061011632 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1191061011633 SLBB domain; Region: SLBB; pfam10531 1191061011634 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 1191061011635 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1191061011636 active site 1191061011637 GalU regulator GalF; Provisional; Region: PRK10122 1191061011638 active site 1191061011639 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1191061011640 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1191061011641 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 1191061011642 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1191061011643 Transporter associated domain; Region: CorC_HlyC; smart01091 1191061011644 putative assembly protein; Provisional; Region: PRK10833 1191061011645 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1191061011646 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1191061011647 trimer interface [polypeptide binding]; other site 1191061011648 active site 1191061011649 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1191061011650 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1191061011651 ATP-binding site [chemical binding]; other site 1191061011652 Sugar specificity; other site 1191061011653 Pyrimidine base specificity; other site 1191061011654 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 1191061011655 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1191061011656 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1191061011657 minor groove reading motif; other site 1191061011658 helix-hairpin-helix signature motif; other site 1191061011659 substrate binding pocket [chemical binding]; other site 1191061011660 active site 1191061011661 putative chaperone; Provisional; Region: PRK11678 1191061011662 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 1191061011663 nucleotide binding site [chemical binding]; other site 1191061011664 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1191061011665 SBD interface [polypeptide binding]; other site 1191061011666 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1191061011667 dimer interface [polypeptide binding]; other site 1191061011668 Citrate synthase; Region: Citrate_synt; pfam00285 1191061011669 active site 1191061011670 citrylCoA binding site [chemical binding]; other site 1191061011671 NADH binding [chemical binding]; other site 1191061011672 cationic pore residues; other site 1191061011673 oxalacetate/citrate binding site [chemical binding]; other site 1191061011674 coenzyme A binding site [chemical binding]; other site 1191061011675 catalytic triad [active] 1191061011676 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 1191061011677 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1191061011678 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1191061011679 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191061011680 dimer interface [polypeptide binding]; other site 1191061011681 phosphorylation site [posttranslational modification] 1191061011682 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191061011683 ATP binding site [chemical binding]; other site 1191061011684 Mg2+ binding site [ion binding]; other site 1191061011685 G-X-G motif; other site 1191061011686 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1191061011687 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191061011688 active site 1191061011689 phosphorylation site [posttranslational modification] 1191061011690 intermolecular recognition site; other site 1191061011691 dimerization interface [polypeptide binding]; other site 1191061011692 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1191061011693 DNA binding site [nucleotide binding] 1191061011694 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1191061011695 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1191061011696 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1191061011697 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1191061011698 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1191061011699 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1191061011700 Walker A/P-loop; other site 1191061011701 ATP binding site [chemical binding]; other site 1191061011702 Q-loop/lid; other site 1191061011703 ABC transporter signature motif; other site 1191061011704 Walker B; other site 1191061011705 D-loop; other site 1191061011706 H-loop/switch region; other site 1191061011707 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1191061011708 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1191061011709 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1191061011710 Walker A/P-loop; other site 1191061011711 ATP binding site [chemical binding]; other site 1191061011712 Q-loop/lid; other site 1191061011713 ABC transporter signature motif; other site 1191061011714 Walker B; other site 1191061011715 D-loop; other site 1191061011716 H-loop/switch region; other site 1191061011717 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1191061011718 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1191061011719 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1191061011720 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061011721 dimer interface [polypeptide binding]; other site 1191061011722 conserved gate region; other site 1191061011723 putative PBP binding loops; other site 1191061011724 ABC-ATPase subunit interface; other site 1191061011725 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1191061011726 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061011727 dimer interface [polypeptide binding]; other site 1191061011728 conserved gate region; other site 1191061011729 putative PBP binding loops; other site 1191061011730 ABC-ATPase subunit interface; other site 1191061011731 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1191061011732 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1191061011733 catalytic site [active] 1191061011734 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 1191061011735 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1191061011736 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1191061011737 DNA binding residues [nucleotide binding] 1191061011738 dimerization interface [polypeptide binding]; other site 1191061011739 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1191061011740 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 1191061011741 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1191061011742 active site 1191061011743 Zn binding site [ion binding]; other site 1191061011744 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1191061011745 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1191061011746 AsnC family; Region: AsnC_trans_reg; pfam01037 1191061011747 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1191061011748 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061011749 dimer interface [polypeptide binding]; other site 1191061011750 conserved gate region; other site 1191061011751 putative PBP binding loops; other site 1191061011752 ABC-ATPase subunit interface; other site 1191061011753 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1191061011754 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061011755 dimer interface [polypeptide binding]; other site 1191061011756 conserved gate region; other site 1191061011757 putative PBP binding loops; other site 1191061011758 ABC-ATPase subunit interface; other site 1191061011759 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1191061011760 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1191061011761 substrate binding pocket [chemical binding]; other site 1191061011762 membrane-bound complex binding site; other site 1191061011763 hinge residues; other site 1191061011764 Amidinotransferase; Region: Amidinotransf; cl12043 1191061011765 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 1191061011766 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1191061011767 HlyD family secretion protein; Region: HlyD_3; pfam13437 1191061011768 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1191061011769 Protein export membrane protein; Region: SecD_SecF; cl14618 1191061011770 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 1191061011771 putative transporter; Provisional; Region: PRK10504 1191061011772 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061011773 putative substrate translocation pore; other site 1191061011774 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061011775 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 1191061011776 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1191061011777 dimerization interface [polypeptide binding]; other site 1191061011778 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191061011779 dimer interface [polypeptide binding]; other site 1191061011780 phosphorylation site [posttranslational modification] 1191061011781 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191061011782 ATP binding site [chemical binding]; other site 1191061011783 Mg2+ binding site [ion binding]; other site 1191061011784 G-X-G motif; other site 1191061011785 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 1191061011786 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191061011787 active site 1191061011788 phosphorylation site [posttranslational modification] 1191061011789 intermolecular recognition site; other site 1191061011790 dimerization interface [polypeptide binding]; other site 1191061011791 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1191061011792 DNA binding site [nucleotide binding] 1191061011793 putative protease; Provisional; Region: PRK15452 1191061011794 Peptidase family U32; Region: Peptidase_U32; pfam01136 1191061011795 tail protein; Provisional; Region: D; PHA02561 1191061011796 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 1191061011797 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1191061011798 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 1191061011799 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1191061011800 Phage tail tube protein FII; Region: Phage_tube; cl01390 1191061011801 major tail sheath protein; Provisional; Region: FI; PHA02560 1191061011802 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 1191061011803 CotH protein; Region: CotH; pfam08757 1191061011804 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 1191061011805 baseplate assembly protein; Provisional; Region: J; PHA02568 1191061011806 baseplate wedge subunit; Provisional; Region: W; PHA02516 1191061011807 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 1191061011808 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 1191061011809 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 1191061011810 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 1191061011811 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 1191061011812 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 1191061011813 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1191061011814 catalytic residue [active] 1191061011815 Phage holin family 2; Region: Phage_holin_2; pfam04550 1191061011816 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 1191061011817 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 1191061011818 terminase endonuclease subunit; Provisional; Region: M; PHA02537 1191061011819 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 1191061011820 Phage major capsid protein, P2 family; Region: Phage_cap_P2; pfam05125 1191061011821 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; pfam05929 1191061011822 terminase ATPase subunit; Provisional; Region: P; PHA02535 1191061011823 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 1191061011824 portal vertex protein; Provisional; Region: Q; PHA02536 1191061011825 Phage portal protein; Region: Phage_portal; pfam04860 1191061011826 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1191061011827 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 1191061011828 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 1191061011829 integrase; Provisional; Region: int; PHA02601 1191061011830 Phage HP1 integrase, C-terminal catalytic domain. Bacteriophage HP1 and related integrases are found in eubacteria, plasmids and temperate bacteriophages of the P2 family. They belong to the DNA breaking-rejoining enzyme superfamily, which includes...; Region: HP1_INT_C; cd00797 1191061011831 dimer interface [polypeptide binding]; other site 1191061011832 active site 1191061011833 catalytic residues [active] 1191061011834 Int/Topo IB signature motif; other site 1191061011835 lipid kinase; Reviewed; Region: PRK13054 1191061011836 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1191061011837 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1191061011838 DNA binding site [nucleotide binding] 1191061011839 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1191061011840 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1191061011841 Walker A/P-loop; other site 1191061011842 ATP binding site [chemical binding]; other site 1191061011843 Q-loop/lid; other site 1191061011844 ABC transporter signature motif; other site 1191061011845 Walker B; other site 1191061011846 D-loop; other site 1191061011847 H-loop/switch region; other site 1191061011848 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1191061011849 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1191061011850 Walker A/P-loop; other site 1191061011851 ATP binding site [chemical binding]; other site 1191061011852 Q-loop/lid; other site 1191061011853 ABC transporter signature motif; other site 1191061011854 Walker B; other site 1191061011855 D-loop; other site 1191061011856 H-loop/switch region; other site 1191061011857 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1191061011858 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1191061011859 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1191061011860 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061011861 dimer interface [polypeptide binding]; other site 1191061011862 conserved gate region; other site 1191061011863 ABC-ATPase subunit interface; other site 1191061011864 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1191061011865 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061011866 dimer interface [polypeptide binding]; other site 1191061011867 conserved gate region; other site 1191061011868 putative PBP binding loops; other site 1191061011869 ABC-ATPase subunit interface; other site 1191061011870 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1191061011871 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 1191061011872 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 4. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_4; cd03329 1191061011873 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1191061011874 putative active site pocket [active] 1191061011875 metal binding site [ion binding]; metal-binding site 1191061011876 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1191061011877 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1191061011878 motif II; other site 1191061011879 polyol permease family; Region: 2A0118; TIGR00897 1191061011880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061011881 putative substrate translocation pore; other site 1191061011882 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1191061011883 N- and C-terminal domain interface [polypeptide binding]; other site 1191061011884 D-xylulose kinase; Region: XylB; TIGR01312 1191061011885 active site 1191061011886 MgATP binding site [chemical binding]; other site 1191061011887 catalytic site [active] 1191061011888 metal binding site [ion binding]; metal-binding site 1191061011889 xylulose binding site [chemical binding]; other site 1191061011890 homodimer interface [polypeptide binding]; other site 1191061011891 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1191061011892 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1191061011893 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1191061011894 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1191061011895 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1191061011896 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1191061011897 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1191061011898 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1191061011899 DNA binding site [nucleotide binding] 1191061011900 domain linker motif; other site 1191061011901 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1191061011902 dimerization interface [polypeptide binding]; other site 1191061011903 ligand binding site [chemical binding]; other site 1191061011904 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1191061011905 classical (c) SDRs; Region: SDR_c; cd05233 1191061011906 NAD(P) binding site [chemical binding]; other site 1191061011907 active site 1191061011908 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 1191061011909 FGGY-family pentulose kinase; Region: 5C_CHO_kinase; TIGR01315 1191061011910 N- and C-terminal domain interface [polypeptide binding]; other site 1191061011911 active site 1191061011912 MgATP binding site [chemical binding]; other site 1191061011913 catalytic site [active] 1191061011914 metal binding site [ion binding]; metal-binding site 1191061011915 carbohydrate binding site [chemical binding]; other site 1191061011916 putative homodimer interface [polypeptide binding]; other site 1191061011917 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 1191061011918 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1191061011919 putative active site; other site 1191061011920 catalytic residue [active] 1191061011921 nucleoside transporter; Region: 2A0110; TIGR00889 1191061011922 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061011923 putative substrate translocation pore; other site 1191061011924 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 1191061011925 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1191061011926 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1191061011927 substrate binding site [chemical binding]; other site 1191061011928 ATP binding site [chemical binding]; other site 1191061011929 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1191061011930 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1191061011931 DNA-binding site [nucleotide binding]; DNA binding site 1191061011932 UTRA domain; Region: UTRA; pfam07702 1191061011933 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1191061011934 dimer interface [polypeptide binding]; other site 1191061011935 substrate binding site [chemical binding]; other site 1191061011936 ATP binding site [chemical binding]; other site 1191061011937 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1191061011938 substrate binding site [chemical binding]; other site 1191061011939 multimerization interface [polypeptide binding]; other site 1191061011940 ATP binding site [chemical binding]; other site 1191061011941 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1191061011942 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1191061011943 Presynaptic Site I dimer interface [polypeptide binding]; other site 1191061011944 catalytic residues [active] 1191061011945 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1191061011946 Synaptic Flat tetramer interface [polypeptide binding]; other site 1191061011947 Synaptic Site I dimer interface [polypeptide binding]; other site 1191061011948 DNA binding site [nucleotide binding] 1191061011949 Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; Region: FReD; cl00085 1191061011950 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1191061011951 active site 1191061011952 DNA binding site [nucleotide binding] 1191061011953 Int/Topo IB signature motif; other site 1191061011954 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 1191061011955 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1191061011956 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1191061011957 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061011958 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061011959 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1191061011960 dimerization interface [polypeptide binding]; other site 1191061011961 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1191061011962 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1191061011963 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1191061011964 active site 1191061011965 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1191061011966 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1191061011967 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061011968 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061011969 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1191061011970 putative effector binding pocket; other site 1191061011971 dimerization interface [polypeptide binding]; other site 1191061011972 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 1191061011973 antiporter inner membrane protein; Provisional; Region: PRK11670 1191061011974 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1191061011975 Walker A motif; other site 1191061011976 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 1191061011977 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1191061011978 active site 1191061011979 KMSKS motif; other site 1191061011980 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1191061011981 tRNA binding surface [nucleotide binding]; other site 1191061011982 anticodon binding site; other site 1191061011983 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1191061011984 dimer interface [polypeptide binding]; other site 1191061011985 putative tRNA-binding site [nucleotide binding]; other site 1191061011986 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 1191061011987 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 1191061011988 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1191061011989 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1191061011990 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 1191061011991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191061011992 active site 1191061011993 phosphorylation site [posttranslational modification] 1191061011994 intermolecular recognition site; other site 1191061011995 dimerization interface [polypeptide binding]; other site 1191061011996 LytTr DNA-binding domain; Region: LytTR; pfam04397 1191061011997 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1191061011998 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1191061011999 GAF domain; Region: GAF; pfam01590 1191061012000 Histidine kinase; Region: His_kinase; pfam06580 1191061012001 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191061012002 ATP binding site [chemical binding]; other site 1191061012003 Mg2+ binding site [ion binding]; other site 1191061012004 G-X-G motif; other site 1191061012005 transcriptional regulator MirA; Provisional; Region: PRK15043 1191061012006 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 1191061012007 DNA binding residues [nucleotide binding] 1191061012008 hypothetical protein; Provisional; Region: PRK13681 1191061012009 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061012010 putative PBP binding loops; other site 1191061012011 ABC-ATPase subunit interface; other site 1191061012012 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1191061012013 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1191061012014 Walker A/P-loop; other site 1191061012015 ATP binding site [chemical binding]; other site 1191061012016 Q-loop/lid; other site 1191061012017 ABC transporter signature motif; other site 1191061012018 Walker B; other site 1191061012019 D-loop; other site 1191061012020 H-loop/switch region; other site 1191061012021 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1191061012022 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1191061012023 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1191061012024 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1191061012025 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1191061012026 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1191061012027 D-lactate dehydrogenase; Provisional; Region: PRK11183 1191061012028 FAD binding domain; Region: FAD_binding_4; pfam01565 1191061012029 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 1191061012030 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1191061012031 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1191061012032 Coenzyme A binding pocket [chemical binding]; other site 1191061012033 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 1191061012034 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1191061012035 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 1191061012036 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1191061012037 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1191061012038 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 1191061012039 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191061012040 S-adenosylmethionine binding site [chemical binding]; other site 1191061012041 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1191061012042 beta-galactosidase; Region: BGL; TIGR03356 1191061012043 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 1191061012044 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1191061012045 active site turn [active] 1191061012046 phosphorylation site [posttranslational modification] 1191061012047 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1191061012048 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1191061012049 HPr interaction site; other site 1191061012050 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1191061012051 active site 1191061012052 phosphorylation site [posttranslational modification] 1191061012053 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1191061012054 CAT RNA binding domain; Region: CAT_RBD; smart01061 1191061012055 PRD domain; Region: PRD; pfam00874 1191061012056 PRD domain; Region: PRD; pfam00874 1191061012057 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 1191061012058 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1191061012059 FMN binding site [chemical binding]; other site 1191061012060 active site 1191061012061 catalytic residues [active] 1191061012062 substrate binding site [chemical binding]; other site 1191061012063 salicylate hydroxylase; Provisional; Region: PRK08163 1191061012064 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1191061012065 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 1191061012066 maleylacetoacetate isomerase; Region: maiA; TIGR01262 1191061012067 C-terminal domain interface [polypeptide binding]; other site 1191061012068 GSH binding site (G-site) [chemical binding]; other site 1191061012069 putative dimer interface [polypeptide binding]; other site 1191061012070 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 1191061012071 dimer interface [polypeptide binding]; other site 1191061012072 N-terminal domain interface [polypeptide binding]; other site 1191061012073 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 1191061012074 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1191061012075 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1191061012076 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 1191061012077 Cupin domain; Region: Cupin_2; pfam07883 1191061012078 Cupin domain; Region: Cupin_2; pfam07883 1191061012079 benzoate transport; Region: 2A0115; TIGR00895 1191061012080 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061012081 putative substrate translocation pore; other site 1191061012082 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061012083 putative substrate translocation pore; other site 1191061012084 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061012085 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061012086 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1191061012087 dimerization interface [polypeptide binding]; other site 1191061012088 hypothetical protein; Provisional; Region: PRK01821 1191061012089 hypothetical protein; Provisional; Region: PRK10711 1191061012090 cytidine deaminase; Provisional; Region: PRK09027 1191061012091 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1191061012092 active site 1191061012093 catalytic motif [active] 1191061012094 Zn binding site [ion binding]; other site 1191061012095 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1191061012096 active site 1191061012097 catalytic motif [active] 1191061012098 Zn binding site [ion binding]; other site 1191061012099 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1191061012100 putative active site [active] 1191061012101 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1191061012102 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1191061012103 TM-ABC transporter signature motif; other site 1191061012104 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1191061012105 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 1191061012106 Walker A/P-loop; other site 1191061012107 ATP binding site [chemical binding]; other site 1191061012108 Q-loop/lid; other site 1191061012109 ABC transporter signature motif; other site 1191061012110 Walker B; other site 1191061012111 D-loop; other site 1191061012112 H-loop/switch region; other site 1191061012113 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1191061012114 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 1191061012115 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 1191061012116 ligand binding site [chemical binding]; other site 1191061012117 calcium binding site [ion binding]; other site 1191061012118 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 1191061012119 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1191061012120 DNA binding site [nucleotide binding] 1191061012121 domain linker motif; other site 1191061012122 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1191061012123 dimerization interface (closed form) [polypeptide binding]; other site 1191061012124 ligand binding site [chemical binding]; other site 1191061012125 Predicted membrane protein [Function unknown]; Region: COG2311 1191061012126 hypothetical protein; Provisional; Region: PRK10835 1191061012127 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1191061012128 GTP cyclohydrolase I; Provisional; Region: PLN03044 1191061012129 active site 1191061012130 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1191061012131 S-formylglutathione hydrolase; Region: PLN02442 1191061012132 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 1191061012133 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1191061012134 N-terminal plug; other site 1191061012135 ligand-binding site [chemical binding]; other site 1191061012136 lysine transporter; Provisional; Region: PRK10836 1191061012137 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 1191061012138 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061012139 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1191061012140 putative dimerization interface [polypeptide binding]; other site 1191061012141 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 1191061012142 endonuclease IV; Provisional; Region: PRK01060 1191061012143 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1191061012144 AP (apurinic/apyrimidinic) site pocket; other site 1191061012145 DNA interaction; other site 1191061012146 Metal-binding active site; metal-binding site 1191061012147 putative kinase; Provisional; Region: PRK09954 1191061012148 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1191061012149 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 1191061012150 substrate binding site [chemical binding]; other site 1191061012151 ATP binding site [chemical binding]; other site 1191061012152 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1191061012153 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1191061012154 Nucleoside recognition; Region: Gate; pfam07670 1191061012155 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1191061012156 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 1191061012157 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 1191061012158 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1191061012159 substrate binding site [chemical binding]; other site 1191061012160 ATP binding site [chemical binding]; other site 1191061012161 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 1191061012162 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 1191061012163 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 1191061012164 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1191061012165 active site 1191061012166 P-loop; other site 1191061012167 phosphorylation site [posttranslational modification] 1191061012168 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1191061012169 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1191061012170 putative substrate binding site [chemical binding]; other site 1191061012171 putative ATP binding site [chemical binding]; other site 1191061012172 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 1191061012173 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1191061012174 active site 1191061012175 phosphorylation site [posttranslational modification] 1191061012176 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1191061012177 dimerization domain swap beta strand [polypeptide binding]; other site 1191061012178 regulatory protein interface [polypeptide binding]; other site 1191061012179 active site 1191061012180 regulatory phosphorylation site [posttranslational modification]; other site 1191061012181 sugar efflux transporter B; Provisional; Region: PRK15011 1191061012182 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061012183 putative substrate translocation pore; other site 1191061012184 elongation factor P; Provisional; Region: PRK04542 1191061012185 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1191061012186 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1191061012187 RNA binding site [nucleotide binding]; other site 1191061012188 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1191061012189 RNA binding site [nucleotide binding]; other site 1191061012190 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1191061012191 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1191061012192 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1191061012193 potential frameshift: common BLAST hit: gi|375261949|ref|YP_005021119.1| cobalamin synthesis protein P47K 1191061012194 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1191061012195 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1191061012196 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1191061012197 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1191061012198 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1191061012199 active site 1191061012200 NlpC/P60 family; Region: NLPC_P60; pfam00877 1191061012201 phage resistance protein; Provisional; Region: PRK10551 1191061012202 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1191061012203 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1191061012204 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1191061012205 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1191061012206 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 1191061012207 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061012208 dimer interface [polypeptide binding]; other site 1191061012209 conserved gate region; other site 1191061012210 putative PBP binding loops; other site 1191061012211 ABC-ATPase subunit interface; other site 1191061012212 microcin C ABC transporter permease; Provisional; Region: PRK15021 1191061012213 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061012214 dimer interface [polypeptide binding]; other site 1191061012215 conserved gate region; other site 1191061012216 ABC-ATPase subunit interface; other site 1191061012217 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 1191061012218 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1191061012219 Walker A/P-loop; other site 1191061012220 ATP binding site [chemical binding]; other site 1191061012221 Q-loop/lid; other site 1191061012222 ABC transporter signature motif; other site 1191061012223 Walker B; other site 1191061012224 D-loop; other site 1191061012225 H-loop/switch region; other site 1191061012226 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1191061012227 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1191061012228 Walker A/P-loop; other site 1191061012229 ATP binding site [chemical binding]; other site 1191061012230 Q-loop/lid; other site 1191061012231 ABC transporter signature motif; other site 1191061012232 Walker B; other site 1191061012233 D-loop; other site 1191061012234 H-loop/switch region; other site 1191061012235 hypothetical protein; Provisional; Region: PRK11835 1191061012236 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061012237 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1191061012238 putative substrate translocation pore; other site 1191061012239 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 1191061012240 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1191061012241 RNA binding surface [nucleotide binding]; other site 1191061012242 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1191061012243 active site 1191061012244 uracil binding [chemical binding]; other site 1191061012245 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1191061012246 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1191061012247 ATP binding site [chemical binding]; other site 1191061012248 putative Mg++ binding site [ion binding]; other site 1191061012249 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1191061012250 nucleotide binding region [chemical binding]; other site 1191061012251 ATP-binding site [chemical binding]; other site 1191061012252 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1191061012253 5S rRNA interface [nucleotide binding]; other site 1191061012254 CTC domain interface [polypeptide binding]; other site 1191061012255 L16 interface [polypeptide binding]; other site 1191061012256 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 1191061012257 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1191061012258 dimer interface [polypeptide binding]; other site 1191061012259 ADP-ribose binding site [chemical binding]; other site 1191061012260 active site 1191061012261 nudix motif; other site 1191061012262 metal binding site [ion binding]; metal-binding site 1191061012263 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1191061012264 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1191061012265 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1191061012266 Nucleoid-associated protein [General function prediction only]; Region: COG3081 1191061012267 nucleoid-associated protein NdpA; Validated; Region: PRK00378 1191061012268 hypothetical protein; Provisional; Region: PRK13689 1191061012269 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 1191061012270 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 1191061012271 Sulfatase; Region: Sulfatase; cl17466 1191061012272 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 1191061012273 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 1191061012274 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 1191061012275 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1191061012276 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 1191061012277 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1191061012278 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 1191061012279 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 1191061012280 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 1191061012281 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1191061012282 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 1191061012283 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1191061012284 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1191061012285 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 1191061012286 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 1191061012287 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 1191061012288 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1191061012289 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191061012290 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1191061012291 Walker A motif; other site 1191061012292 ATP binding site [chemical binding]; other site 1191061012293 Walker B motif; other site 1191061012294 arginine finger; other site 1191061012295 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 1191061012296 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1191061012297 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1191061012298 ligand binding site [chemical binding]; other site 1191061012299 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 1191061012300 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 1191061012301 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1191061012302 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 1191061012303 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1191061012304 Protein of unknown function (DUF770); Region: DUF770; pfam05591 1191061012305 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1191061012306 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1191061012307 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 1191061012308 secondary substrate binding site; other site 1191061012309 primary substrate binding site; other site 1191061012310 inhibition loop; other site 1191061012311 dimerization interface [polypeptide binding]; other site 1191061012312 malate:quinone oxidoreductase; Validated; Region: PRK05257 1191061012313 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1191061012314 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1191061012315 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1191061012316 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1191061012317 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1191061012318 MgtE intracellular N domain; Region: MgtE_N; smart00924 1191061012319 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1191061012320 Divalent cation transporter; Region: MgtE; cl00786 1191061012321 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 1191061012322 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1191061012323 Walker A/P-loop; other site 1191061012324 ATP binding site [chemical binding]; other site 1191061012325 Q-loop/lid; other site 1191061012326 ABC transporter signature motif; other site 1191061012327 Walker B; other site 1191061012328 D-loop; other site 1191061012329 H-loop/switch region; other site 1191061012330 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 1191061012331 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 1191061012332 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1191061012333 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061012334 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1191061012335 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1191061012336 DNA binding site [nucleotide binding] 1191061012337 active site 1191061012338 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 1191061012339 ApbE family; Region: ApbE; pfam02424 1191061012340 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1191061012341 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1191061012342 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 1191061012343 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191061012344 ATP binding site [chemical binding]; other site 1191061012345 G-X-G motif; other site 1191061012346 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1191061012347 putative binding surface; other site 1191061012348 active site 1191061012349 transcriptional regulator RcsB; Provisional; Region: PRK10840 1191061012350 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191061012351 active site 1191061012352 phosphorylation site [posttranslational modification] 1191061012353 intermolecular recognition site; other site 1191061012354 dimerization interface [polypeptide binding]; other site 1191061012355 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1191061012356 DNA binding residues [nucleotide binding] 1191061012357 dimerization interface [polypeptide binding]; other site 1191061012358 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 1191061012359 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191061012360 dimer interface [polypeptide binding]; other site 1191061012361 phosphorylation site [posttranslational modification] 1191061012362 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191061012363 ATP binding site [chemical binding]; other site 1191061012364 Mg2+ binding site [ion binding]; other site 1191061012365 G-X-G motif; other site 1191061012366 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 1191061012367 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191061012368 active site 1191061012369 phosphorylation site [posttranslational modification] 1191061012370 intermolecular recognition site; other site 1191061012371 dimerization interface [polypeptide binding]; other site 1191061012372 DNA gyrase subunit A; Validated; Region: PRK05560 1191061012373 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1191061012374 CAP-like domain; other site 1191061012375 active site 1191061012376 primary dimer interface [polypeptide binding]; other site 1191061012377 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1191061012378 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1191061012379 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1191061012380 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1191061012381 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1191061012382 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1191061012383 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1191061012384 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191061012385 S-adenosylmethionine binding site [chemical binding]; other site 1191061012386 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 1191061012387 ATP cone domain; Region: ATP-cone; pfam03477 1191061012388 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1191061012389 active site 1191061012390 dimer interface [polypeptide binding]; other site 1191061012391 catalytic residues [active] 1191061012392 effector binding site; other site 1191061012393 R2 peptide binding site; other site 1191061012394 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1191061012395 dimer interface [polypeptide binding]; other site 1191061012396 putative radical transfer pathway; other site 1191061012397 diiron center [ion binding]; other site 1191061012398 tyrosyl radical; other site 1191061012399 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1191061012400 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1191061012401 catalytic loop [active] 1191061012402 iron binding site [ion binding]; other site 1191061012403 choline dehydrogenase; Validated; Region: PRK02106 1191061012404 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1191061012405 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1191061012406 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061012407 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061012408 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1191061012409 putative effector binding pocket; other site 1191061012410 dimerization interface [polypeptide binding]; other site 1191061012411 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 1191061012412 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 1191061012413 active site 1191061012414 catalytic site [active] 1191061012415 metal binding site [ion binding]; metal-binding site 1191061012416 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 1191061012417 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061012418 putative substrate translocation pore; other site 1191061012419 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 1191061012420 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1191061012421 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1191061012422 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 1191061012423 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 1191061012424 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 1191061012425 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1191061012426 Cysteine-rich domain; Region: CCG; pfam02754 1191061012427 Cysteine-rich domain; Region: CCG; pfam02754 1191061012428 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 1191061012429 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1191061012430 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061012431 putative substrate translocation pore; other site 1191061012432 L-rhamnonate dehydratase; Provisional; Region: PRK15440 1191061012433 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 1191061012434 putative active site pocket [active] 1191061012435 putative metal binding site [ion binding]; other site 1191061012436 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1191061012437 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1191061012438 Bacterial transcriptional regulator; Region: IclR; pfam01614 1191061012439 hypothetical protein; Provisional; Region: PRK03673 1191061012440 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1191061012441 putative MPT binding site; other site 1191061012442 Competence-damaged protein; Region: CinA; cl00666 1191061012443 YfaZ precursor; Region: YfaZ; pfam07437 1191061012444 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 1191061012445 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1191061012446 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1191061012447 tetramer interface [polypeptide binding]; other site 1191061012448 heme binding pocket [chemical binding]; other site 1191061012449 NADPH binding site [chemical binding]; other site 1191061012450 hypothetical protein; Provisional; Region: PRK09956 1191061012451 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1191061012452 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 1191061012453 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 1191061012454 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 1191061012455 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1191061012456 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191061012457 dimer interface [polypeptide binding]; other site 1191061012458 phosphorylation site [posttranslational modification] 1191061012459 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191061012460 ATP binding site [chemical binding]; other site 1191061012461 Mg2+ binding site [ion binding]; other site 1191061012462 G-X-G motif; other site 1191061012463 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 1191061012464 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191061012465 active site 1191061012466 phosphorylation site [posttranslational modification] 1191061012467 intermolecular recognition site; other site 1191061012468 dimerization interface [polypeptide binding]; other site 1191061012469 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1191061012470 DNA binding site [nucleotide binding] 1191061012471 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1191061012472 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1191061012473 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1191061012474 hypothetical protein; Provisional; Region: PRK09867 1191061012475 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 1191061012476 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1191061012477 acyl-activating enzyme (AAE) consensus motif; other site 1191061012478 putative AMP binding site [chemical binding]; other site 1191061012479 putative active site [active] 1191061012480 putative CoA binding site [chemical binding]; other site 1191061012481 O-succinylbenzoate synthase; Provisional; Region: PRK05105 1191061012482 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1191061012483 active site 1191061012484 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1191061012485 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1191061012486 substrate binding site [chemical binding]; other site 1191061012487 oxyanion hole (OAH) forming residues; other site 1191061012488 trimer interface [polypeptide binding]; other site 1191061012489 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 1191061012490 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cl00341 1191061012491 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1191061012492 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1191061012493 dimer interface [polypeptide binding]; other site 1191061012494 tetramer interface [polypeptide binding]; other site 1191061012495 PYR/PP interface [polypeptide binding]; other site 1191061012496 TPP binding site [chemical binding]; other site 1191061012497 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1191061012498 TPP-binding site; other site 1191061012499 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 1191061012500 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1191061012501 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1191061012502 Coenzyme A binding pocket [chemical binding]; other site 1191061012503 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1191061012504 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1191061012505 active site 1191061012506 DNA binding site [nucleotide binding] 1191061012507 Int/Topo IB signature motif; other site 1191061012508 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1191061012509 Fimbrial protein; Region: Fimbrial; cl01416 1191061012510 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1191061012511 PapC N-terminal domain; Region: PapC_N; pfam13954 1191061012512 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1191061012513 PapC C-terminal domain; Region: PapC_C; pfam13953 1191061012514 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1191061012515 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1191061012516 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1191061012517 Fimbrial protein; Region: Fimbrial; cl01416 1191061012518 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1191061012519 active site 1191061012520 DNA binding site [nucleotide binding] 1191061012521 Int/Topo IB signature motif; other site 1191061012522 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1191061012523 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1191061012524 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1191061012525 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1191061012526 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1191061012527 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1191061012528 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1191061012529 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1191061012530 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1191061012531 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1191061012532 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 1191061012533 4Fe-4S binding domain; Region: Fer4; pfam00037 1191061012534 4Fe-4S binding domain; Region: Fer4; pfam00037 1191061012535 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1191061012536 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 1191061012537 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1191061012538 catalytic loop [active] 1191061012539 iron binding site [ion binding]; other site 1191061012540 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1191061012541 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 1191061012542 [4Fe-4S] binding site [ion binding]; other site 1191061012543 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1191061012544 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 1191061012545 SLBB domain; Region: SLBB; pfam10531 1191061012546 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1191061012547 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1191061012548 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1191061012549 putative dimer interface [polypeptide binding]; other site 1191061012550 [2Fe-2S] cluster binding site [ion binding]; other site 1191061012551 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 1191061012552 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1191061012553 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1191061012554 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 1191061012555 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1191061012556 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 1191061012557 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061012558 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 1191061012559 putative dimerization interface [polypeptide binding]; other site 1191061012560 aminotransferase AlaT; Validated; Region: PRK09265 1191061012561 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1191061012562 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061012563 homodimer interface [polypeptide binding]; other site 1191061012564 catalytic residue [active] 1191061012565 5'-nucleotidase; Provisional; Region: PRK03826 1191061012566 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1191061012567 transmembrane helices; other site 1191061012568 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1191061012569 TrkA-C domain; Region: TrkA_C; pfam02080 1191061012570 TrkA-C domain; Region: TrkA_C; pfam02080 1191061012571 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1191061012572 putative phosphatase; Provisional; Region: PRK11587 1191061012573 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1191061012574 motif II; other site 1191061012575 hypothetical protein; Validated; Region: PRK05445 1191061012576 hypothetical protein; Provisional; Region: PRK01816 1191061012577 propionate/acetate kinase; Provisional; Region: PRK12379 1191061012578 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1191061012579 phosphate acetyltransferase; Reviewed; Region: PRK05632 1191061012580 DRTGG domain; Region: DRTGG; pfam07085 1191061012581 phosphate acetyltransferase; Region: pta; TIGR00651 1191061012582 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1191061012583 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1191061012584 PYR/PP interface [polypeptide binding]; other site 1191061012585 dimer interface [polypeptide binding]; other site 1191061012586 TPP binding site [chemical binding]; other site 1191061012587 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1191061012588 transketolase; Reviewed; Region: PRK05899 1191061012589 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1191061012590 TPP-binding site [chemical binding]; other site 1191061012591 dimer interface [polypeptide binding]; other site 1191061012592 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK12996 1191061012593 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1191061012594 active site 1191061012595 P-loop; other site 1191061012596 phosphorylation site [posttranslational modification] 1191061012597 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1191061012598 active site 1191061012599 phosphorylation site [posttranslational modification] 1191061012600 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1191061012601 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1191061012602 DNA binding site [nucleotide binding] 1191061012603 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1191061012604 putative dimerization interface [polypeptide binding]; other site 1191061012605 putative ligand binding site [chemical binding]; other site 1191061012606 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 1191061012607 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 1191061012608 nudix motif; other site 1191061012609 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1191061012610 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1191061012611 active site 1191061012612 metal binding site [ion binding]; metal-binding site 1191061012613 homotetramer interface [polypeptide binding]; other site 1191061012614 glutathione S-transferase; Provisional; Region: PRK15113 1191061012615 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1191061012616 C-terminal domain interface [polypeptide binding]; other site 1191061012617 GSH binding site (G-site) [chemical binding]; other site 1191061012618 dimer interface [polypeptide binding]; other site 1191061012619 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 1191061012620 N-terminal domain interface [polypeptide binding]; other site 1191061012621 putative dimer interface [polypeptide binding]; other site 1191061012622 putative substrate binding pocket (H-site) [chemical binding]; other site 1191061012623 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1191061012624 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1191061012625 C-terminal domain interface [polypeptide binding]; other site 1191061012626 GSH binding site (G-site) [chemical binding]; other site 1191061012627 dimer interface [polypeptide binding]; other site 1191061012628 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 1191061012629 N-terminal domain interface [polypeptide binding]; other site 1191061012630 putative dimer interface [polypeptide binding]; other site 1191061012631 active site 1191061012632 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1191061012633 homooctamer interface [polypeptide binding]; other site 1191061012634 active site 1191061012635 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1191061012636 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1191061012637 putative NAD(P) binding site [chemical binding]; other site 1191061012638 putative active site [active] 1191061012639 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1191061012640 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1191061012641 Coenzyme A binding pocket [chemical binding]; other site 1191061012642 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 1191061012643 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1191061012644 Walker A/P-loop; other site 1191061012645 ATP binding site [chemical binding]; other site 1191061012646 Q-loop/lid; other site 1191061012647 ABC transporter signature motif; other site 1191061012648 Walker B; other site 1191061012649 D-loop; other site 1191061012650 H-loop/switch region; other site 1191061012651 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1191061012652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061012653 dimer interface [polypeptide binding]; other site 1191061012654 conserved gate region; other site 1191061012655 putative PBP binding loops; other site 1191061012656 ABC-ATPase subunit interface; other site 1191061012657 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1191061012658 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061012659 dimer interface [polypeptide binding]; other site 1191061012660 conserved gate region; other site 1191061012661 putative PBP binding loops; other site 1191061012662 ABC-ATPase subunit interface; other site 1191061012663 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 1191061012664 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1191061012665 substrate binding pocket [chemical binding]; other site 1191061012666 membrane-bound complex binding site; other site 1191061012667 hinge residues; other site 1191061012668 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 1191061012669 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1191061012670 substrate binding pocket [chemical binding]; other site 1191061012671 membrane-bound complex binding site; other site 1191061012672 hinge residues; other site 1191061012673 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 1191061012674 Flavoprotein; Region: Flavoprotein; pfam02441 1191061012675 amidophosphoribosyltransferase; Provisional; Region: PRK09246 1191061012676 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1191061012677 active site 1191061012678 tetramer interface [polypeptide binding]; other site 1191061012679 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1191061012680 active site 1191061012681 colicin V production protein; Provisional; Region: PRK10845 1191061012682 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1191061012683 cell division protein DedD; Provisional; Region: PRK11633 1191061012684 Sporulation related domain; Region: SPOR; pfam05036 1191061012685 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 1191061012686 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1191061012687 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1191061012688 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1191061012689 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1191061012690 hypothetical protein; Provisional; Region: PRK10847 1191061012691 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1191061012692 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1191061012693 dimerization interface 3.5A [polypeptide binding]; other site 1191061012694 active site 1191061012695 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 1191061012696 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1191061012697 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 1191061012698 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 1191061012699 ligand binding site [chemical binding]; other site 1191061012700 NAD binding site [chemical binding]; other site 1191061012701 catalytic site [active] 1191061012702 homodimer interface [polypeptide binding]; other site 1191061012703 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 1191061012704 putative transporter; Provisional; Region: PRK12382 1191061012705 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061012706 putative substrate translocation pore; other site 1191061012707 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 1191061012708 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1191061012709 dimer interface [polypeptide binding]; other site 1191061012710 active site 1191061012711 Uncharacterized conserved protein [Function unknown]; Region: COG4121 1191061012712 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 1191061012713 YfcL protein; Region: YfcL; pfam08891 1191061012714 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 1191061012715 hypothetical protein; Provisional; Region: PRK10621 1191061012716 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1191061012717 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 1191061012718 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 1191061012719 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1191061012720 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1191061012721 Tetramer interface [polypeptide binding]; other site 1191061012722 active site 1191061012723 FMN-binding site [chemical binding]; other site 1191061012724 HemK family putative methylases; Region: hemK_fam; TIGR00536 1191061012725 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191061012726 S-adenosylmethionine binding site [chemical binding]; other site 1191061012727 hypothetical protein; Provisional; Region: PRK04946 1191061012728 Smr domain; Region: Smr; pfam01713 1191061012729 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1191061012730 catalytic core [active] 1191061012731 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1191061012732 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1191061012733 substrate binding site [chemical binding]; other site 1191061012734 oxyanion hole (OAH) forming residues; other site 1191061012735 trimer interface [polypeptide binding]; other site 1191061012736 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1191061012737 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1191061012738 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 1191061012739 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1191061012740 dimer interface [polypeptide binding]; other site 1191061012741 active site 1191061012742 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 1191061012743 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 1191061012744 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 1191061012745 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1191061012746 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1191061012747 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 1191061012748 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061012749 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 1191061012750 dimerization interface [polypeptide binding]; other site 1191061012751 putative cyanate transporter; Provisional; Region: cynX; PRK09705 1191061012752 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061012753 aminotransferase; Validated; Region: PRK08175 1191061012754 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1191061012755 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061012756 homodimer interface [polypeptide binding]; other site 1191061012757 catalytic residue [active] 1191061012758 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1191061012759 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1191061012760 GAF domain; Region: GAF; pfam01590 1191061012761 Histidine kinase; Region: His_kinase; pfam06580 1191061012762 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191061012763 ATP binding site [chemical binding]; other site 1191061012764 Mg2+ binding site [ion binding]; other site 1191061012765 G-X-G motif; other site 1191061012766 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1191061012767 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191061012768 active site 1191061012769 phosphorylation site [posttranslational modification] 1191061012770 intermolecular recognition site; other site 1191061012771 dimerization interface [polypeptide binding]; other site 1191061012772 LytTr DNA-binding domain; Region: LytTR; pfam04397 1191061012773 glucokinase; Provisional; Region: glk; PRK00292 1191061012774 glucokinase, proteobacterial type; Region: glk; TIGR00749 1191061012775 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1191061012776 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1191061012777 Cl- selectivity filter; other site 1191061012778 Cl- binding residues [ion binding]; other site 1191061012779 pore gating glutamate residue; other site 1191061012780 dimer interface [polypeptide binding]; other site 1191061012781 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 1191061012782 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1191061012783 dimer interface [polypeptide binding]; other site 1191061012784 PYR/PP interface [polypeptide binding]; other site 1191061012785 TPP binding site [chemical binding]; other site 1191061012786 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1191061012787 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1191061012788 TPP-binding site [chemical binding]; other site 1191061012789 dimer interface [polypeptide binding]; other site 1191061012790 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1191061012791 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1191061012792 active site 1191061012793 catalytic tetrad [active] 1191061012794 manganese transport protein MntH; Reviewed; Region: PRK00701 1191061012795 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1191061012796 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1191061012797 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1191061012798 Nucleoside recognition; Region: Gate; pfam07670 1191061012799 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1191061012800 MASE1; Region: MASE1; pfam05231 1191061012801 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1191061012802 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1191061012803 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1191061012804 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 1191061012805 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 1191061012806 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1191061012807 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1191061012808 active site 1191061012809 HIGH motif; other site 1191061012810 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1191061012811 active site 1191061012812 KMSKS motif; other site 1191061012813 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1191061012814 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061012815 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 1191061012816 putative dimerization interface [polypeptide binding]; other site 1191061012817 putative substrate binding pocket [chemical binding]; other site 1191061012818 nucleoside transporter; Region: 2A0110; TIGR00889 1191061012819 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1191061012820 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061012821 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061012822 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1191061012823 putative dimerization interface [polypeptide binding]; other site 1191061012824 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1191061012825 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1191061012826 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 1191061012827 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1191061012828 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1191061012829 nucleotide binding pocket [chemical binding]; other site 1191061012830 K-X-D-G motif; other site 1191061012831 catalytic site [active] 1191061012832 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1191061012833 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1191061012834 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1191061012835 Dimer interface [polypeptide binding]; other site 1191061012836 BRCT sequence motif; other site 1191061012837 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 1191061012838 cell division protein ZipA; Provisional; Region: PRK03427 1191061012839 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 1191061012840 FtsZ protein binding site [polypeptide binding]; other site 1191061012841 putative sulfate transport protein CysZ; Validated; Region: PRK04949 1191061012842 potential frameshift: common BLAST hit: gi|375262145|ref|YP_005021315.1| cysteine synthase A 1191061012843 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1191061012844 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1191061012845 dimer interface [polypeptide binding]; other site 1191061012846 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061012847 catalytic residue [active] 1191061012848 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1191061012849 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1191061012850 dimerization domain swap beta strand [polypeptide binding]; other site 1191061012851 regulatory protein interface [polypeptide binding]; other site 1191061012852 active site 1191061012853 regulatory phosphorylation site [posttranslational modification]; other site 1191061012854 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 1191061012855 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1191061012856 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1191061012857 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1191061012858 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1191061012859 HPr interaction site; other site 1191061012860 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1191061012861 active site 1191061012862 phosphorylation site [posttranslational modification] 1191061012863 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1191061012864 dimer interface [polypeptide binding]; other site 1191061012865 pyridoxamine kinase; Validated; Region: PRK05756 1191061012866 pyridoxal binding site [chemical binding]; other site 1191061012867 ATP binding site [chemical binding]; other site 1191061012868 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 1191061012869 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1191061012870 DNA-binding site [nucleotide binding]; DNA binding site 1191061012871 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1191061012872 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061012873 homodimer interface [polypeptide binding]; other site 1191061012874 catalytic residue [active] 1191061012875 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1191061012876 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1191061012877 catalytic triad [active] 1191061012878 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1191061012879 cysteine synthase B; Region: cysM; TIGR01138 1191061012880 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1191061012881 dimer interface [polypeptide binding]; other site 1191061012882 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061012883 catalytic residue [active] 1191061012884 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 1191061012885 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1191061012886 Walker A/P-loop; other site 1191061012887 ATP binding site [chemical binding]; other site 1191061012888 Q-loop/lid; other site 1191061012889 ABC transporter signature motif; other site 1191061012890 Walker B; other site 1191061012891 D-loop; other site 1191061012892 H-loop/switch region; other site 1191061012893 TOBE-like domain; Region: TOBE_3; pfam12857 1191061012894 sulfate transport protein; Provisional; Region: cysT; CHL00187 1191061012895 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061012896 dimer interface [polypeptide binding]; other site 1191061012897 conserved gate region; other site 1191061012898 putative PBP binding loops; other site 1191061012899 ABC-ATPase subunit interface; other site 1191061012900 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1191061012901 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061012902 dimer interface [polypeptide binding]; other site 1191061012903 conserved gate region; other site 1191061012904 putative PBP binding loops; other site 1191061012905 ABC-ATPase subunit interface; other site 1191061012906 thiosulfate transporter subunit; Provisional; Region: PRK10852 1191061012907 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1191061012908 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1191061012909 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 1191061012910 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 1191061012911 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 1191061012912 putative acetyltransferase; Provisional; Region: PRK03624 1191061012913 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1191061012914 Coenzyme A binding pocket [chemical binding]; other site 1191061012915 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 1191061012916 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1191061012917 active site 1191061012918 metal binding site [ion binding]; metal-binding site 1191061012919 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1191061012920 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1191061012921 transcriptional regulator EutR; Provisional; Region: PRK10130 1191061012922 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061012923 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061012924 carboxysome structural protein EutK; Provisional; Region: PRK15466 1191061012925 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1191061012926 Hexamer interface [polypeptide binding]; other site 1191061012927 Hexagonal pore residue; other site 1191061012928 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 1191061012929 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 1191061012930 putative hexamer interface [polypeptide binding]; other site 1191061012931 putative hexagonal pore; other site 1191061012932 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 1191061012933 putative hexamer interface [polypeptide binding]; other site 1191061012934 putative hexagonal pore; other site 1191061012935 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 1191061012936 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 1191061012937 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 1191061012938 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 1191061012939 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 1191061012940 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 1191061012941 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 1191061012942 active site 1191061012943 metal binding site [ion binding]; metal-binding site 1191061012944 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 1191061012945 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1191061012946 nucleotide binding site [chemical binding]; other site 1191061012947 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 1191061012948 putative catalytic cysteine [active] 1191061012949 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 1191061012950 Hexamer/Pentamer interface [polypeptide binding]; other site 1191061012951 central pore; other site 1191061012952 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1191061012953 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1191061012954 Hexamer interface [polypeptide binding]; other site 1191061012955 Hexagonal pore residue; other site 1191061012956 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1191061012957 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 1191061012958 potential frameshift: common BLAST hit: gi|375262179|ref|YP_005021349.1| ethanolamine utilization protein EutQ 1191061012959 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 1191061012960 Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249 1191061012961 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 1191061012962 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1191061012963 G1 box; other site 1191061012964 GTP/Mg2+ binding site [chemical binding]; other site 1191061012965 G2 box; other site 1191061012966 Switch I region; other site 1191061012967 G3 box; other site 1191061012968 Switch II region; other site 1191061012969 G4 box; other site 1191061012970 G5 box; other site 1191061012971 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 1191061012972 putative hexamer interface [polypeptide binding]; other site 1191061012973 putative hexagonal pore; other site 1191061012974 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 1191061012975 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1191061012976 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1191061012977 putative NAD(P) binding site [chemical binding]; other site 1191061012978 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1191061012979 transketolase; Reviewed; Region: PRK12753 1191061012980 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1191061012981 TPP-binding site [chemical binding]; other site 1191061012982 dimer interface [polypeptide binding]; other site 1191061012983 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1191061012984 PYR/PP interface [polypeptide binding]; other site 1191061012985 dimer interface [polypeptide binding]; other site 1191061012986 TPP binding site [chemical binding]; other site 1191061012987 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1191061012988 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 1191061012989 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 1191061012990 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1191061012991 dimer interface [polypeptide binding]; other site 1191061012992 ADP-ribose binding site [chemical binding]; other site 1191061012993 active site 1191061012994 nudix motif; other site 1191061012995 metal binding site [ion binding]; metal-binding site 1191061012996 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 1191061012997 4Fe-4S binding domain; Region: Fer4; pfam00037 1191061012998 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1191061012999 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1191061013000 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 1191061013001 Protein export membrane protein; Region: SecD_SecF; cl14618 1191061013002 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 1191061013003 ArsC family; Region: ArsC; pfam03960 1191061013004 putative catalytic residues [active] 1191061013005 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1191061013006 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1191061013007 metal binding site [ion binding]; metal-binding site 1191061013008 dimer interface [polypeptide binding]; other site 1191061013009 hypothetical protein; Provisional; Region: PRK13664 1191061013010 putative hydrolase; Provisional; Region: PRK11460 1191061013011 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 1191061013012 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 1191061013013 Helicase; Region: Helicase_RecD; pfam05127 1191061013014 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 1191061013015 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 1191061013016 Predicted metalloprotease [General function prediction only]; Region: COG2321 1191061013017 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1191061013018 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1191061013019 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1191061013020 ATP binding site [chemical binding]; other site 1191061013021 active site 1191061013022 substrate binding site [chemical binding]; other site 1191061013023 lipoprotein; Provisional; Region: PRK11679 1191061013024 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 1191061013025 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1191061013026 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1191061013027 dimer interface [polypeptide binding]; other site 1191061013028 active site 1191061013029 catalytic residue [active] 1191061013030 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 1191061013031 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 1191061013032 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1191061013033 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1191061013034 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1191061013035 catalytic triad [active] 1191061013036 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1191061013037 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1191061013038 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 1191061013039 Peptidase family M48; Region: Peptidase_M48; cl12018 1191061013040 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1191061013041 ArsC family; Region: ArsC; pfam03960 1191061013042 catalytic residues [active] 1191061013043 DNA replication initiation factor; Provisional; Region: PRK08084 1191061013044 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1191061013045 uracil transporter; Provisional; Region: PRK10720 1191061013046 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1191061013047 active site 1191061013048 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 1191061013049 beta-galactosidase; Region: BGL; TIGR03356 1191061013050 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1191061013051 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1191061013052 nucleotide binding site [chemical binding]; other site 1191061013053 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1191061013054 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1191061013055 dimerization interface [polypeptide binding]; other site 1191061013056 putative ATP binding site [chemical binding]; other site 1191061013057 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1191061013058 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1191061013059 active site 1191061013060 substrate binding site [chemical binding]; other site 1191061013061 cosubstrate binding site; other site 1191061013062 catalytic site [active] 1191061013063 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 1191061013064 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1191061013065 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1191061013066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061013067 putative substrate translocation pore; other site 1191061013068 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1191061013069 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 1191061013070 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1191061013071 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1191061013072 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1191061013073 putative active site [active] 1191061013074 catalytic site [active] 1191061013075 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 1191061013076 domain interface [polypeptide binding]; other site 1191061013077 active site 1191061013078 catalytic site [active] 1191061013079 exopolyphosphatase; Provisional; Region: PRK10854 1191061013080 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1191061013081 MASE1; Region: MASE1; pfam05231 1191061013082 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1191061013083 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1191061013084 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1191061013085 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 1191061013086 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061013087 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061013088 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1191061013089 dimerization interface [polypeptide binding]; other site 1191061013090 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1191061013091 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061013092 putative substrate translocation pore; other site 1191061013093 GMP synthase; Reviewed; Region: guaA; PRK00074 1191061013094 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1191061013095 AMP/PPi binding site [chemical binding]; other site 1191061013096 candidate oxyanion hole; other site 1191061013097 catalytic triad [active] 1191061013098 potential glutamine specificity residues [chemical binding]; other site 1191061013099 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1191061013100 ATP Binding subdomain [chemical binding]; other site 1191061013101 Ligand Binding sites [chemical binding]; other site 1191061013102 Dimerization subdomain; other site 1191061013103 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1191061013104 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1191061013105 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1191061013106 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1191061013107 active site 1191061013108 potential frameshift: common BLAST hit: gi|375262221|ref|YP_005021391.1| exodeoxyribonuclease VII large subunit 1191061013109 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1191061013110 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1191061013111 generic binding surface II; other site 1191061013112 generic binding surface I; other site 1191061013113 Exonuclease VII, large subunit; Region: Exonuc_VII_L; pfam02601 1191061013114 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1191061013115 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1191061013116 active site 1191061013117 Zn binding site [ion binding]; other site 1191061013118 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 1191061013119 TolA C-terminal; Region: TolA; pfam06519 1191061013120 transport protein TonB; Provisional; Region: PRK10819 1191061013121 GTP-binding protein Der; Reviewed; Region: PRK00093 1191061013122 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1191061013123 G1 box; other site 1191061013124 GTP/Mg2+ binding site [chemical binding]; other site 1191061013125 Switch I region; other site 1191061013126 G2 box; other site 1191061013127 Switch II region; other site 1191061013128 G3 box; other site 1191061013129 G4 box; other site 1191061013130 G5 box; other site 1191061013131 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1191061013132 G1 box; other site 1191061013133 GTP/Mg2+ binding site [chemical binding]; other site 1191061013134 Switch I region; other site 1191061013135 G2 box; other site 1191061013136 G3 box; other site 1191061013137 Switch II region; other site 1191061013138 G4 box; other site 1191061013139 G5 box; other site 1191061013140 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 1191061013141 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 1191061013142 Trp docking motif [polypeptide binding]; other site 1191061013143 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 1191061013144 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 1191061013145 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1191061013146 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1191061013147 dimer interface [polypeptide binding]; other site 1191061013148 motif 1; other site 1191061013149 active site 1191061013150 motif 2; other site 1191061013151 motif 3; other site 1191061013152 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1191061013153 anticodon binding site; other site 1191061013154 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1191061013155 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1191061013156 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1191061013157 cytoskeletal protein RodZ; Provisional; Region: PRK10856 1191061013158 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1191061013159 non-specific DNA binding site [nucleotide binding]; other site 1191061013160 salt bridge; other site 1191061013161 sequence-specific DNA binding site [nucleotide binding]; other site 1191061013162 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1191061013163 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 1191061013164 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1191061013165 FeS/SAM binding site; other site 1191061013166 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1191061013167 active site 1191061013168 multimer interface [polypeptide binding]; other site 1191061013169 penicillin-binding protein 1C; Provisional; Region: PRK11240 1191061013170 Transglycosylase; Region: Transgly; pfam00912 1191061013171 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1191061013172 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 1191061013173 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1191061013174 MG2 domain; Region: A2M_N; pfam01835 1191061013175 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1191061013176 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 1191061013177 surface patch; other site 1191061013178 thioester region; other site 1191061013179 specificity defining residues; other site 1191061013180 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1191061013181 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 1191061013182 metal binding site [ion binding]; metal-binding site 1191061013183 putative dimer interface [polypeptide binding]; other site 1191061013184 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 1191061013185 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1191061013186 active site residue [active] 1191061013187 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1191061013188 active site residue [active] 1191061013189 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 1191061013190 aminopeptidase B; Provisional; Region: PRK05015 1191061013191 Peptidase; Region: DUF3663; pfam12404 1191061013192 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1191061013193 interface (dimer of trimers) [polypeptide binding]; other site 1191061013194 Substrate-binding/catalytic site; other site 1191061013195 Zn-binding sites [ion binding]; other site 1191061013196 hypothetical protein; Provisional; Region: PRK10721 1191061013197 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1191061013198 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1191061013199 catalytic loop [active] 1191061013200 iron binding site [ion binding]; other site 1191061013201 chaperone protein HscA; Provisional; Region: hscA; PRK05183 1191061013202 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 1191061013203 nucleotide binding site [chemical binding]; other site 1191061013204 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1191061013205 SBD interface [polypeptide binding]; other site 1191061013206 co-chaperone HscB; Provisional; Region: hscB; PRK05014 1191061013207 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1191061013208 HSP70 interaction site [polypeptide binding]; other site 1191061013209 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 1191061013210 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 1191061013211 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1191061013212 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1191061013213 trimerization site [polypeptide binding]; other site 1191061013214 active site 1191061013215 cysteine desulfurase; Provisional; Region: PRK14012 1191061013216 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1191061013217 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1191061013218 catalytic residue [active] 1191061013219 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 1191061013220 Rrf2 family protein; Region: rrf2_super; TIGR00738 1191061013221 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 1191061013222 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1191061013223 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1191061013224 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1191061013225 active site 1191061013226 dimerization interface [polypeptide binding]; other site 1191061013227 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 1191061013228 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 1191061013229 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 1191061013230 PRD domain; Region: PRD; pfam00874 1191061013231 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 1191061013232 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061013233 putative substrate translocation pore; other site 1191061013234 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 1191061013235 active site 1191061013236 catalytic residues [active] 1191061013237 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 1191061013238 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061013239 putative substrate translocation pore; other site 1191061013240 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061013241 TPR repeat; Region: TPR_11; pfam13414 1191061013242 TPR repeat; Region: TPR_11; pfam13414 1191061013243 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1191061013244 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1191061013245 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1191061013246 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1191061013247 Predicted membrane protein [Function unknown]; Region: COG2259 1191061013248 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1191061013249 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1191061013250 dimer interface [polypeptide binding]; other site 1191061013251 active site 1191061013252 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1191061013253 folate binding site [chemical binding]; other site 1191061013254 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1191061013255 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1191061013256 heme-binding site [chemical binding]; other site 1191061013257 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1191061013258 FAD binding pocket [chemical binding]; other site 1191061013259 FAD binding motif [chemical binding]; other site 1191061013260 phosphate binding motif [ion binding]; other site 1191061013261 beta-alpha-beta structure motif; other site 1191061013262 NAD binding pocket [chemical binding]; other site 1191061013263 Heme binding pocket [chemical binding]; other site 1191061013264 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 1191061013265 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1191061013266 response regulator GlrR; Provisional; Region: PRK15115 1191061013267 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191061013268 active site 1191061013269 phosphorylation site [posttranslational modification] 1191061013270 intermolecular recognition site; other site 1191061013271 dimerization interface [polypeptide binding]; other site 1191061013272 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191061013273 Walker A motif; other site 1191061013274 ATP binding site [chemical binding]; other site 1191061013275 Walker B motif; other site 1191061013276 arginine finger; other site 1191061013277 hypothetical protein; Provisional; Region: PRK10722 1191061013278 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1191061013279 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191061013280 dimer interface [polypeptide binding]; other site 1191061013281 phosphorylation site [posttranslational modification] 1191061013282 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191061013283 ATP binding site [chemical binding]; other site 1191061013284 Mg2+ binding site [ion binding]; other site 1191061013285 G-X-G motif; other site 1191061013286 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 1191061013287 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1191061013288 dimerization interface [polypeptide binding]; other site 1191061013289 ATP binding site [chemical binding]; other site 1191061013290 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 1191061013291 dimerization interface [polypeptide binding]; other site 1191061013292 ATP binding site [chemical binding]; other site 1191061013293 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1191061013294 putative active site [active] 1191061013295 catalytic triad [active] 1191061013296 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 1191061013297 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1191061013298 substrate binding pocket [chemical binding]; other site 1191061013299 membrane-bound complex binding site; other site 1191061013300 hinge residues; other site 1191061013301 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1191061013302 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1191061013303 catalytic residue [active] 1191061013304 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1191061013305 nucleoside/Zn binding site; other site 1191061013306 dimer interface [polypeptide binding]; other site 1191061013307 catalytic motif [active] 1191061013308 hypothetical protein; Provisional; Region: PRK11590 1191061013309 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1191061013310 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1191061013311 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 1191061013312 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1191061013313 putative active site [active] 1191061013314 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1191061013315 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1191061013316 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1191061013317 active site 1191061013318 hydrophilic channel; other site 1191061013319 dimerization interface [polypeptide binding]; other site 1191061013320 catalytic residues [active] 1191061013321 active site lid [active] 1191061013322 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1191061013323 Recombination protein O N terminal; Region: RecO_N; pfam11967 1191061013324 Recombination protein O C terminal; Region: RecO_C; pfam02565 1191061013325 GTPase Era; Reviewed; Region: era; PRK00089 1191061013326 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1191061013327 G1 box; other site 1191061013328 GTP/Mg2+ binding site [chemical binding]; other site 1191061013329 Switch I region; other site 1191061013330 G2 box; other site 1191061013331 Switch II region; other site 1191061013332 G3 box; other site 1191061013333 G4 box; other site 1191061013334 G5 box; other site 1191061013335 KH domain; Region: KH_2; pfam07650 1191061013336 ribonuclease III; Reviewed; Region: rnc; PRK00102 1191061013337 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1191061013338 dimerization interface [polypeptide binding]; other site 1191061013339 active site 1191061013340 metal binding site [ion binding]; metal-binding site 1191061013341 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1191061013342 dsRNA binding site [nucleotide binding]; other site 1191061013343 signal peptidase I; Provisional; Region: PRK10861 1191061013344 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1191061013345 Catalytic site [active] 1191061013346 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1191061013347 GTP-binding protein LepA; Provisional; Region: PRK05433 1191061013348 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1191061013349 G1 box; other site 1191061013350 putative GEF interaction site [polypeptide binding]; other site 1191061013351 GTP/Mg2+ binding site [chemical binding]; other site 1191061013352 Switch I region; other site 1191061013353 G2 box; other site 1191061013354 G3 box; other site 1191061013355 Switch II region; other site 1191061013356 G4 box; other site 1191061013357 G5 box; other site 1191061013358 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1191061013359 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1191061013360 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1191061013361 SoxR reducing system protein RseC; Provisional; Region: PRK10862 1191061013362 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 1191061013363 anti-sigma E factor; Provisional; Region: rseB; PRK09455 1191061013364 potential frameshift: common BLAST hit: gi|375262290|ref|YP_005021460.1| anti-RNA polymerase sigma factor SigE 1191061013365 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 1191061013366 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 1191061013367 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 1191061013368 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 1191061013369 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 1191061013370 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1191061013371 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1191061013372 DNA binding residues [nucleotide binding] 1191061013373 L-aspartate oxidase; Provisional; Region: PRK09077 1191061013374 L-aspartate oxidase; Provisional; Region: PRK06175 1191061013375 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1191061013376 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1191061013377 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1191061013378 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1191061013379 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1191061013380 ATP binding site [chemical binding]; other site 1191061013381 Mg++ binding site [ion binding]; other site 1191061013382 motif III; other site 1191061013383 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1191061013384 nucleotide binding region [chemical binding]; other site 1191061013385 ATP-binding site [chemical binding]; other site 1191061013386 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 1191061013387 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1191061013388 ligand binding site [chemical binding]; other site 1191061013389 active site 1191061013390 UGI interface [polypeptide binding]; other site 1191061013391 catalytic site [active] 1191061013392 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1191061013393 putative methyltransferase; Provisional; Region: PRK10864 1191061013394 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1191061013395 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1191061013396 thioredoxin 2; Provisional; Region: PRK10996 1191061013397 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 1191061013398 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1191061013399 catalytic residues [active] 1191061013400 Uncharacterized conserved protein [Function unknown]; Region: COG3148 1191061013401 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1191061013402 CoA binding domain; Region: CoA_binding_2; pfam13380 1191061013403 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1191061013404 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1191061013405 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1191061013406 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1191061013407 Coenzyme A binding pocket [chemical binding]; other site 1191061013408 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 1191061013409 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 1191061013410 domain interface [polypeptide binding]; other site 1191061013411 putative active site [active] 1191061013412 catalytic site [active] 1191061013413 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 1191061013414 domain interface [polypeptide binding]; other site 1191061013415 putative active site [active] 1191061013416 catalytic site [active] 1191061013417 lipoprotein; Provisional; Region: PRK10759 1191061013418 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1191061013419 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061013420 putative substrate translocation pore; other site 1191061013421 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 1191061013422 protein disaggregation chaperone; Provisional; Region: PRK10865 1191061013423 Clp amino terminal domain; Region: Clp_N; pfam02861 1191061013424 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191061013425 Walker A motif; other site 1191061013426 ATP binding site [chemical binding]; other site 1191061013427 Walker B motif; other site 1191061013428 arginine finger; other site 1191061013429 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191061013430 Walker A motif; other site 1191061013431 ATP binding site [chemical binding]; other site 1191061013432 Walker B motif; other site 1191061013433 arginine finger; other site 1191061013434 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1191061013435 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 1191061013436 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1191061013437 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 1191061013438 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1191061013439 RNA binding surface [nucleotide binding]; other site 1191061013440 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1191061013441 active site 1191061013442 Outer membrane lipoprotein; Region: YfiO; pfam13525 1191061013443 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1191061013444 30S subunit binding site; other site 1191061013445 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 1191061013446 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 1191061013447 Prephenate dehydratase; Region: PDT; pfam00800 1191061013448 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1191061013449 putative L-Phe binding site [chemical binding]; other site 1191061013450 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1191061013451 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 1191061013452 Chorismate mutase type II; Region: CM_2; cl00693 1191061013453 prephenate dehydrogenase; Validated; Region: PRK08507 1191061013454 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1191061013455 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1191061013456 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 1191061013457 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 1191061013458 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1191061013459 metal binding site [ion binding]; metal-binding site 1191061013460 active site 1191061013461 I-site; other site 1191061013462 putative outer membrane lipoprotein; Provisional; Region: PRK09967 1191061013463 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1191061013464 ligand binding site [chemical binding]; other site 1191061013465 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1191061013466 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1191061013467 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1191061013468 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 1191061013469 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1191061013470 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1191061013471 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1191061013472 RimM N-terminal domain; Region: RimM; pfam01782 1191061013473 PRC-barrel domain; Region: PRC; pfam05239 1191061013474 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1191061013475 signal recognition particle protein; Provisional; Region: PRK10867 1191061013476 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1191061013477 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1191061013478 P loop; other site 1191061013479 GTP binding site [chemical binding]; other site 1191061013480 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1191061013481 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 1191061013482 hypothetical protein; Provisional; Region: PRK11573 1191061013483 Domain of unknown function DUF21; Region: DUF21; pfam01595 1191061013484 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1191061013485 Transporter associated domain; Region: CorC_HlyC; smart01091 1191061013486 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1191061013487 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1191061013488 dimer interface [polypeptide binding]; other site 1191061013489 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1191061013490 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 1191061013491 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 1191061013492 recombination and repair protein; Provisional; Region: PRK10869 1191061013493 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1191061013494 Walker A/P-loop; other site 1191061013495 ATP binding site [chemical binding]; other site 1191061013496 Q-loop/lid; other site 1191061013497 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1191061013498 ABC transporter signature motif; other site 1191061013499 Walker B; other site 1191061013500 D-loop; other site 1191061013501 H-loop/switch region; other site 1191061013502 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 1191061013503 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1191061013504 hypothetical protein; Validated; Region: PRK01777 1191061013505 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1191061013506 putative coenzyme Q binding site [chemical binding]; other site 1191061013507 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1191061013508 SmpB-tmRNA interface; other site 1191061013509 integrase; Provisional; Region: PRK09692 1191061013510 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1191061013511 active site 1191061013512 Int/Topo IB signature motif; other site 1191061013513 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 1191061013514 Phage polarity suppression protein (Psu); Region: Psu; pfam07455 1191061013515 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 1191061013516 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 1191061013517 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 1191061013518 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 1191061013519 D5 N terminal like; Region: D5_N; smart00885 1191061013520 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 1191061013521 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 1191061013522 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1191061013523 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 1191061013524 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061013525 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061013526 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1191061013527 dimerization interface [polypeptide binding]; other site 1191061013528 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1191061013529 agmatinase; Region: agmatinase; TIGR01230 1191061013530 oligomer interface [polypeptide binding]; other site 1191061013531 putative active site [active] 1191061013532 Mn binding site [ion binding]; other site 1191061013533 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1191061013534 oxidase reductase; Provisional; Region: PTZ00273 1191061013535 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1191061013536 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1191061013537 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1191061013538 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1191061013539 substrate binding pocket [chemical binding]; other site 1191061013540 membrane-bound complex binding site; other site 1191061013541 hinge residues; other site 1191061013542 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061013543 dimer interface [polypeptide binding]; other site 1191061013544 conserved gate region; other site 1191061013545 putative PBP binding loops; other site 1191061013546 ABC-ATPase subunit interface; other site 1191061013547 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1191061013548 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1191061013549 Walker A/P-loop; other site 1191061013550 ATP binding site [chemical binding]; other site 1191061013551 Q-loop/lid; other site 1191061013552 ABC transporter signature motif; other site 1191061013553 Walker B; other site 1191061013554 D-loop; other site 1191061013555 H-loop/switch region; other site 1191061013556 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1191061013557 intersubunit interface [polypeptide binding]; other site 1191061013558 active site 1191061013559 Zn2+ binding site [ion binding]; other site 1191061013560 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 1191061013561 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 1191061013562 putative ligand binding site [chemical binding]; other site 1191061013563 NAD binding site [chemical binding]; other site 1191061013564 dimerization interface [polypeptide binding]; other site 1191061013565 catalytic site [active] 1191061013566 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 1191061013567 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 1191061013568 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 1191061013569 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1191061013570 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 1191061013571 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 1191061013572 Heme exporter protein D (CcmD); Region: CcmD; cl11475 1191061013573 heme exporter protein CcmC; Region: ccmC; TIGR01191 1191061013574 CcmB protein; Region: CcmB; cl17444 1191061013575 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 1191061013576 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1191061013577 Walker A/P-loop; other site 1191061013578 ATP binding site [chemical binding]; other site 1191061013579 Q-loop/lid; other site 1191061013580 ABC transporter signature motif; other site 1191061013581 Walker B; other site 1191061013582 D-loop; other site 1191061013583 H-loop/switch region; other site 1191061013584 Haem-binding domain; Region: Haem_bd; pfam14376 1191061013585 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 1191061013586 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061013587 putative substrate translocation pore; other site 1191061013588 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1191061013589 classical (c) SDRs; Region: SDR_c; cd05233 1191061013590 NAD(P) binding site [chemical binding]; other site 1191061013591 active site 1191061013592 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1191061013593 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061013594 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1191061013595 dimerization interface [polypeptide binding]; other site 1191061013596 substrate binding pocket [chemical binding]; other site 1191061013597 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1191061013598 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1191061013599 substrate binding pocket [chemical binding]; other site 1191061013600 membrane-bound complex binding site; other site 1191061013601 hinge residues; other site 1191061013602 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1191061013603 trimer interface [polypeptide binding]; other site 1191061013604 active site 1191061013605 substrate binding site [chemical binding]; other site 1191061013606 CoA binding site [chemical binding]; other site 1191061013607 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1191061013608 PapC C-terminal domain; Region: PapC_C; pfam13953 1191061013609 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1191061013610 PapC N-terminal domain; Region: PapC_N; pfam13954 1191061013611 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1191061013612 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1191061013613 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1191061013614 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1191061013615 Fimbrial protein; Region: Fimbrial; cl01416 1191061013616 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1191061013617 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1191061013618 NAD(P) binding site [chemical binding]; other site 1191061013619 catalytic residues [active] 1191061013620 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1191061013621 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191061013622 Walker A motif; other site 1191061013623 ATP binding site [chemical binding]; other site 1191061013624 Walker B motif; other site 1191061013625 arginine finger; other site 1191061013626 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1191061013627 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1191061013628 dimerization interface [polypeptide binding]; other site 1191061013629 putative DNA binding site [nucleotide binding]; other site 1191061013630 putative Zn2+ binding site [ion binding]; other site 1191061013631 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1191061013632 active site residue [active] 1191061013633 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 1191061013634 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1191061013635 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 1191061013636 hypothetical protein; Provisional; Region: PRK10556 1191061013637 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 1191061013638 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1191061013639 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1191061013640 DNA-binding site [nucleotide binding]; DNA binding site 1191061013641 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1191061013642 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061013643 homodimer interface [polypeptide binding]; other site 1191061013644 catalytic residue [active] 1191061013645 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1191061013646 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1191061013647 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1191061013648 catalytic residues [active] 1191061013649 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1191061013650 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1191061013651 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1191061013652 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1191061013653 active site 1191061013654 dimer interface [polypeptide binding]; other site 1191061013655 catalytic residues [active] 1191061013656 effector binding site; other site 1191061013657 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1191061013658 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1191061013659 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1191061013660 dimer interface [polypeptide binding]; other site 1191061013661 putative radical transfer pathway; other site 1191061013662 diiron center [ion binding]; other site 1191061013663 tyrosyl radical; other site 1191061013664 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 1191061013665 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1191061013666 Walker A/P-loop; other site 1191061013667 ATP binding site [chemical binding]; other site 1191061013668 Q-loop/lid; other site 1191061013669 ABC transporter signature motif; other site 1191061013670 Walker B; other site 1191061013671 D-loop; other site 1191061013672 H-loop/switch region; other site 1191061013673 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1191061013674 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1191061013675 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061013676 dimer interface [polypeptide binding]; other site 1191061013677 conserved gate region; other site 1191061013678 putative PBP binding loops; other site 1191061013679 ABC-ATPase subunit interface; other site 1191061013680 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 1191061013681 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1191061013682 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1191061013683 putative L-valine exporter; Provisional; Region: PRK10408 1191061013684 transcriptional repressor MprA; Provisional; Region: PRK10870 1191061013685 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1191061013686 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 1191061013687 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1191061013688 HlyD family secretion protein; Region: HlyD_3; pfam13437 1191061013689 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1191061013690 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061013691 putative substrate translocation pore; other site 1191061013692 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061013693 2-isopropylmalate synthase; Validated; Region: PRK03739 1191061013694 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1191061013695 active site 1191061013696 catalytic residues [active] 1191061013697 metal binding site [ion binding]; metal-binding site 1191061013698 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1191061013699 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1191061013700 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1191061013701 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061013702 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1191061013703 glutamate--cysteine ligase; Provisional; Region: PRK02107 1191061013704 Predicted membrane protein [Function unknown]; Region: COG1238 1191061013705 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 1191061013706 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1191061013707 motif II; other site 1191061013708 BON domain; Region: BON; pfam04972 1191061013709 carbon storage regulator; Provisional; Region: PRK01712 1191061013710 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1191061013711 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1191061013712 motif 1; other site 1191061013713 active site 1191061013714 motif 2; other site 1191061013715 motif 3; other site 1191061013716 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1191061013717 DHHA1 domain; Region: DHHA1; pfam02272 1191061013718 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1191061013719 recombinase A; Provisional; Region: recA; PRK09354 1191061013720 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1191061013721 hexamer interface [polypeptide binding]; other site 1191061013722 Walker A motif; other site 1191061013723 ATP binding site [chemical binding]; other site 1191061013724 Walker B motif; other site 1191061013725 hypothetical protein; Validated; Region: PRK03661 1191061013726 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1191061013727 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1191061013728 metal binding site [ion binding]; metal-binding site 1191061013729 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1191061013730 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1191061013731 ABC-ATPase subunit interface; other site 1191061013732 dimer interface [polypeptide binding]; other site 1191061013733 putative PBP binding regions; other site 1191061013734 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1191061013735 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1191061013736 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1191061013737 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1191061013738 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1191061013739 catalytic residue [active] 1191061013740 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 1191061013741 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 1191061013742 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 1191061013743 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 1191061013744 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 1191061013745 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 1191061013746 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 1191061013747 putative NAD(P) binding site [chemical binding]; other site 1191061013748 active site 1191061013749 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 1191061013750 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 1191061013751 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1191061013752 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1191061013753 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 1191061013754 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1191061013755 putative active site [active] 1191061013756 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1191061013757 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 1191061013758 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1191061013759 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191061013760 Walker A motif; other site 1191061013761 ATP binding site [chemical binding]; other site 1191061013762 Walker B motif; other site 1191061013763 arginine finger; other site 1191061013764 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 1191061013765 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1191061013766 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1191061013767 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1191061013768 iron binding site [ion binding]; other site 1191061013769 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 1191061013770 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1191061013771 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1191061013772 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 1191061013773 potential frameshift: common BLAST hit: gi|375256942|ref|YP_005016112.1| hydrogenase maturation protein 1191061013774 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 1191061013775 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 1191061013776 Acylphosphatase; Region: Acylphosphatase; pfam00708 1191061013777 HypF finger; Region: zf-HYPF; pfam07503 1191061013778 HypF finger; Region: zf-HYPF; pfam07503 1191061013779 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 1191061013780 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 1191061013781 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1191061013782 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1191061013783 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1191061013784 DNA binding site [nucleotide binding] 1191061013785 domain linker motif; other site 1191061013786 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1191061013787 dimerization interface (closed form) [polypeptide binding]; other site 1191061013788 ligand binding site [chemical binding]; other site 1191061013789 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 1191061013790 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1191061013791 active site turn [active] 1191061013792 phosphorylation site [posttranslational modification] 1191061013793 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 1191061013794 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 1191061013795 beta-galactosidase; Region: BGL; TIGR03356 1191061013796 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 1191061013797 nickel binding site [ion binding]; other site 1191061013798 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 1191061013799 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 1191061013800 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 1191061013801 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1191061013802 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 1191061013803 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 1191061013804 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1191061013805 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1191061013806 NADH dehydrogenase; Region: NADHdh; cl00469 1191061013807 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 1191061013808 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1191061013809 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 1191061013810 Transcriptional repressor of hyc and hyp operons; Region: HycA_repressor; pfam11046 1191061013811 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 1191061013812 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 1191061013813 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 1191061013814 hydrogenase assembly chaperone; Provisional; Region: PRK10409 1191061013815 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 1191061013816 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 1191061013817 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 1191061013818 dimerization interface [polypeptide binding]; other site 1191061013819 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 1191061013820 ATP binding site [chemical binding]; other site 1191061013821 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 1191061013822 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1191061013823 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1191061013824 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191061013825 Walker A motif; other site 1191061013826 ATP binding site [chemical binding]; other site 1191061013827 Walker B motif; other site 1191061013828 arginine finger; other site 1191061013829 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1191061013830 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1191061013831 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1191061013832 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1191061013833 beta-galactosidase; Region: BGL; TIGR03356 1191061013834 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1191061013835 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 1191061013836 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1191061013837 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1191061013838 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1191061013839 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1191061013840 active site 1191061013841 P-loop; other site 1191061013842 phosphorylation site [posttranslational modification] 1191061013843 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1191061013844 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1191061013845 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1191061013846 methionine cluster; other site 1191061013847 active site 1191061013848 phosphorylation site [posttranslational modification] 1191061013849 metal binding site [ion binding]; metal-binding site 1191061013850 fructokinase; Reviewed; Region: PRK09557 1191061013851 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1191061013852 nucleotide binding site [chemical binding]; other site 1191061013853 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1191061013854 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1191061013855 DNA binding site [nucleotide binding] 1191061013856 domain linker motif; other site 1191061013857 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1191061013858 ligand binding site [chemical binding]; other site 1191061013859 dimerization interface [polypeptide binding]; other site 1191061013860 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1191061013861 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1191061013862 metal binding site [ion binding]; metal-binding site 1191061013863 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 1191061013864 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1191061013865 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1191061013866 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1191061013867 ABC-ATPase subunit interface; other site 1191061013868 dimer interface [polypeptide binding]; other site 1191061013869 putative PBP binding regions; other site 1191061013870 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1191061013871 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1191061013872 ABC-ATPase subunit interface; other site 1191061013873 dimer interface [polypeptide binding]; other site 1191061013874 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 1191061013875 Rdx family; Region: Rdx; cl01407 1191061013876 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 1191061013877 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1191061013878 N-terminal plug; other site 1191061013879 ligand-binding site [chemical binding]; other site 1191061013880 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 1191061013881 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 1191061013882 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 1191061013883 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 1191061013884 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1191061013885 putative hemin binding site; other site 1191061013886 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1191061013887 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1191061013888 ABC-ATPase subunit interface; other site 1191061013889 dimer interface [polypeptide binding]; other site 1191061013890 putative PBP binding regions; other site 1191061013891 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1191061013892 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1191061013893 Walker A/P-loop; other site 1191061013894 ATP binding site [chemical binding]; other site 1191061013895 Q-loop/lid; other site 1191061013896 ABC transporter signature motif; other site 1191061013897 Walker B; other site 1191061013898 D-loop; other site 1191061013899 H-loop/switch region; other site 1191061013900 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 1191061013901 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1191061013902 metal binding site [ion binding]; metal-binding site 1191061013903 substrate binding pocket [chemical binding]; other site 1191061013904 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 1191061013905 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1191061013906 NADP binding site [chemical binding]; other site 1191061013907 homodimer interface [polypeptide binding]; other site 1191061013908 active site 1191061013909 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061013910 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 1191061013911 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 1191061013912 putative NAD(P) binding site [chemical binding]; other site 1191061013913 catalytic Zn binding site [ion binding]; other site 1191061013914 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1191061013915 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1191061013916 DNA-binding site [nucleotide binding]; DNA binding site 1191061013917 FCD domain; Region: FCD; pfam07729 1191061013918 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 1191061013919 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1191061013920 dimer interface [polypeptide binding]; other site 1191061013921 active site 1191061013922 metal binding site [ion binding]; metal-binding site 1191061013923 FaeA-like protein; Region: FaeA; pfam04703 1191061013924 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1191061013925 DNA binding site [nucleotide binding] 1191061013926 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1191061013927 Zn2+ binding site [ion binding]; other site 1191061013928 Mg2+ binding site [ion binding]; other site 1191061013929 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1191061013930 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1191061013931 NAD(P) binding site [chemical binding]; other site 1191061013932 active site 1191061013933 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1191061013934 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1191061013935 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1191061013936 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1191061013937 dimer interface [polypeptide binding]; other site 1191061013938 active site 1191061013939 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1191061013940 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 1191061013941 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1191061013942 Walker A/P-loop; other site 1191061013943 ATP binding site [chemical binding]; other site 1191061013944 Q-loop/lid; other site 1191061013945 ABC transporter signature motif; other site 1191061013946 Walker B; other site 1191061013947 D-loop; other site 1191061013948 H-loop/switch region; other site 1191061013949 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1191061013950 FtsX-like permease family; Region: FtsX; pfam02687 1191061013951 macrolide transporter subunit MacA; Provisional; Region: PRK11578 1191061013952 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1191061013953 HlyD family secretion protein; Region: HlyD_3; pfam13437 1191061013954 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 1191061013955 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1191061013956 putative active site [active] 1191061013957 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1191061013958 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1191061013959 Walker A/P-loop; other site 1191061013960 ATP binding site [chemical binding]; other site 1191061013961 Q-loop/lid; other site 1191061013962 ABC transporter signature motif; other site 1191061013963 Walker B; other site 1191061013964 D-loop; other site 1191061013965 H-loop/switch region; other site 1191061013966 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1191061013967 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1191061013968 catalytic residues [active] 1191061013969 hinge region; other site 1191061013970 alpha helical domain; other site 1191061013971 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1191061013972 dimerization interface [polypeptide binding]; other site 1191061013973 DNA binding residues [nucleotide binding] 1191061013974 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1191061013975 Fimbrial protein; Region: Fimbrial; cl01416 1191061013976 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1191061013977 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1191061013978 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1191061013979 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1191061013980 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 1191061013981 PapC N-terminal domain; Region: PapC_N; pfam13954 1191061013982 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1191061013983 PapC C-terminal domain; Region: PapC_C; pfam13953 1191061013984 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1191061013985 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1191061013986 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1191061013987 MutS domain I; Region: MutS_I; pfam01624 1191061013988 MutS domain II; Region: MutS_II; pfam05188 1191061013989 MutS domain III; Region: MutS_III; pfam05192 1191061013990 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1191061013991 Walker A/P-loop; other site 1191061013992 ATP binding site [chemical binding]; other site 1191061013993 Q-loop/lid; other site 1191061013994 ABC transporter signature motif; other site 1191061013995 Walker B; other site 1191061013996 D-loop; other site 1191061013997 H-loop/switch region; other site 1191061013998 Hok/gef family; Region: HOK_GEF; pfam01848 1191061013999 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 1191061014000 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 1191061014001 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 1191061014002 Flavoprotein; Region: Flavoprotein; pfam02441 1191061014003 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1191061014004 MarR family; Region: MarR_2; cl17246 1191061014005 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061014006 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061014007 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1191061014008 putative effector binding pocket; other site 1191061014009 dimerization interface [polypeptide binding]; other site 1191061014010 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1191061014011 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061014012 putative substrate translocation pore; other site 1191061014013 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 1191061014014 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 1191061014015 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1191061014016 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1191061014017 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1191061014018 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1191061014019 DNA binding residues [nucleotide binding] 1191061014020 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 1191061014021 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1191061014022 Peptidase family M23; Region: Peptidase_M23; pfam01551 1191061014023 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 1191061014024 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191061014025 S-adenosylmethionine binding site [chemical binding]; other site 1191061014026 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1191061014027 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 1191061014028 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 1191061014029 Permutation of conserved domain; other site 1191061014030 active site 1191061014031 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1191061014032 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1191061014033 homotrimer interaction site [polypeptide binding]; other site 1191061014034 zinc binding site [ion binding]; other site 1191061014035 CDP-binding sites; other site 1191061014036 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1191061014037 substrate binding site; other site 1191061014038 dimer interface; other site 1191061014039 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 1191061014040 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1191061014041 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 1191061014042 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1191061014043 ligand-binding site [chemical binding]; other site 1191061014044 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 1191061014045 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1191061014046 CysD dimerization site [polypeptide binding]; other site 1191061014047 G1 box; other site 1191061014048 putative GEF interaction site [polypeptide binding]; other site 1191061014049 GTP/Mg2+ binding site [chemical binding]; other site 1191061014050 Switch I region; other site 1191061014051 G2 box; other site 1191061014052 G3 box; other site 1191061014053 Switch II region; other site 1191061014054 G4 box; other site 1191061014055 G5 box; other site 1191061014056 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1191061014057 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1191061014058 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1191061014059 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1191061014060 Active Sites [active] 1191061014061 siroheme synthase; Provisional; Region: cysG; PRK10637 1191061014062 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1191061014063 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1191061014064 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1191061014065 active site 1191061014066 SAM binding site [chemical binding]; other site 1191061014067 homodimer interface [polypeptide binding]; other site 1191061014068 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 1191061014069 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1191061014070 metal binding site [ion binding]; metal-binding site 1191061014071 TilS substrate C-terminal domain; Region: TilS_C; cl17443 1191061014072 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 1191061014073 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 1191061014074 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09664 1191061014075 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1191061014076 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 1191061014077 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cd09646 1191061014078 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 1191061014079 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669 1191061014080 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1191061014081 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 1191061014082 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1191061014083 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1191061014084 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1191061014085 Active Sites [active] 1191061014086 sulfite reductase subunit beta; Provisional; Region: PRK13504 1191061014087 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1191061014088 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1191061014089 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 1191061014090 Flavodoxin; Region: Flavodoxin_1; pfam00258 1191061014091 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1191061014092 FAD binding pocket [chemical binding]; other site 1191061014093 FAD binding motif [chemical binding]; other site 1191061014094 catalytic residues [active] 1191061014095 NAD binding pocket [chemical binding]; other site 1191061014096 phosphate binding motif [ion binding]; other site 1191061014097 beta-alpha-beta structure motif; other site 1191061014098 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1191061014099 active site 1191061014100 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 1191061014101 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1191061014102 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1191061014103 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1191061014104 NAD(P) binding site [chemical binding]; other site 1191061014105 active site 1191061014106 enolase; Provisional; Region: eno; PRK00077 1191061014107 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1191061014108 dimer interface [polypeptide binding]; other site 1191061014109 metal binding site [ion binding]; metal-binding site 1191061014110 substrate binding pocket [chemical binding]; other site 1191061014111 CTP synthetase; Validated; Region: pyrG; PRK05380 1191061014112 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1191061014113 Catalytic site [active] 1191061014114 active site 1191061014115 UTP binding site [chemical binding]; other site 1191061014116 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1191061014117 active site 1191061014118 putative oxyanion hole; other site 1191061014119 catalytic triad [active] 1191061014120 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1191061014121 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1191061014122 homodimer interface [polypeptide binding]; other site 1191061014123 metal binding site [ion binding]; metal-binding site 1191061014124 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1191061014125 homodimer interface [polypeptide binding]; other site 1191061014126 active site 1191061014127 putative chemical substrate binding site [chemical binding]; other site 1191061014128 metal binding site [ion binding]; metal-binding site 1191061014129 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 1191061014130 HD domain; Region: HD_4; pfam13328 1191061014131 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1191061014132 synthetase active site [active] 1191061014133 NTP binding site [chemical binding]; other site 1191061014134 metal binding site [ion binding]; metal-binding site 1191061014135 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1191061014136 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1191061014137 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 1191061014138 TRAM domain; Region: TRAM; pfam01938 1191061014139 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191061014140 S-adenosylmethionine binding site [chemical binding]; other site 1191061014141 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 1191061014142 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 1191061014143 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1191061014144 dimerization interface [polypeptide binding]; other site 1191061014145 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191061014146 dimer interface [polypeptide binding]; other site 1191061014147 phosphorylation site [posttranslational modification] 1191061014148 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191061014149 ATP binding site [chemical binding]; other site 1191061014150 Mg2+ binding site [ion binding]; other site 1191061014151 G-X-G motif; other site 1191061014152 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 1191061014153 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191061014154 active site 1191061014155 phosphorylation site [posttranslational modification] 1191061014156 intermolecular recognition site; other site 1191061014157 dimerization interface [polypeptide binding]; other site 1191061014158 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1191061014159 putative binding surface; other site 1191061014160 active site 1191061014161 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1191061014162 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1191061014163 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1191061014164 active site 1191061014165 tetramer interface [polypeptide binding]; other site 1191061014166 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1191061014167 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1191061014168 active site 1191061014169 tetramer interface [polypeptide binding]; other site 1191061014170 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061014171 D-galactonate transporter; Region: 2A0114; TIGR00893 1191061014172 putative substrate translocation pore; other site 1191061014173 flavodoxin; Provisional; Region: PRK08105 1191061014174 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1191061014175 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 1191061014176 probable active site [active] 1191061014177 tRNA pseudouridine synthase C; Region: DUF446; pfam04287 1191061014178 SecY interacting protein Syd; Provisional; Region: PRK04968 1191061014179 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 1191061014180 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 1191061014181 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1191061014182 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1191061014183 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 1191061014184 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1191061014185 serine transporter; Region: stp; TIGR00814 1191061014186 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1191061014187 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1191061014188 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1191061014189 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1191061014190 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1191061014191 substrate binding pocket [chemical binding]; other site 1191061014192 membrane-bound complex binding site; other site 1191061014193 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1191061014194 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1191061014195 active site 1191061014196 non-prolyl cis peptide bond; other site 1191061014197 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1191061014198 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1191061014199 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1191061014200 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1191061014201 active site 1191061014202 dimer interface [polypeptide binding]; other site 1191061014203 non-prolyl cis peptide bond; other site 1191061014204 insertion regions; other site 1191061014205 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 1191061014206 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1191061014207 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191061014208 Walker A motif; other site 1191061014209 ATP binding site [chemical binding]; other site 1191061014210 Walker B motif; other site 1191061014211 arginine finger; other site 1191061014212 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1191061014213 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1191061014214 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1191061014215 substrate binding pocket [chemical binding]; other site 1191061014216 membrane-bound complex binding site; other site 1191061014217 hinge residues; other site 1191061014218 flap endonuclease-like protein; Provisional; Region: PRK09482 1191061014219 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1191061014220 active site 1191061014221 metal binding site 1 [ion binding]; metal-binding site 1191061014222 putative 5' ssDNA interaction site; other site 1191061014223 metal binding site 3; metal-binding site 1191061014224 metal binding site 2 [ion binding]; metal-binding site 1191061014225 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1191061014226 putative DNA binding site [nucleotide binding]; other site 1191061014227 putative metal binding site [ion binding]; other site 1191061014228 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1191061014229 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1191061014230 intersubunit interface [polypeptide binding]; other site 1191061014231 active site 1191061014232 Zn2+ binding site [ion binding]; other site 1191061014233 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1191061014234 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061014235 putative substrate translocation pore; other site 1191061014236 L-fucose isomerase; Provisional; Region: fucI; PRK10991 1191061014237 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 1191061014238 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1191061014239 trimer interface [polypeptide binding]; other site 1191061014240 substrate binding site [chemical binding]; other site 1191061014241 Mn binding site [ion binding]; other site 1191061014242 L-fuculokinase; Provisional; Region: PRK10331 1191061014243 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1191061014244 nucleotide binding site [chemical binding]; other site 1191061014245 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 1191061014246 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 1191061014247 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1191061014248 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1191061014249 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 1191061014250 FtsJ-like methyltransferase; Region: FtsJ; cl17430 1191061014251 hypothetical protein; Provisional; Region: PRK10873 1191061014252 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1191061014253 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061014254 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1191061014255 dimerization interface [polypeptide binding]; other site 1191061014256 substrate binding pocket [chemical binding]; other site 1191061014257 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1191061014258 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1191061014259 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1191061014260 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1191061014261 catalytic residue [active] 1191061014262 Fe-S metabolism associated domain; Region: SufE; cl00951 1191061014263 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 1191061014264 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1191061014265 putative ATP binding site [chemical binding]; other site 1191061014266 putative substrate interface [chemical binding]; other site 1191061014267 murein transglycosylase A; Provisional; Region: mltA; PRK11162 1191061014268 MltA specific insert domain; Region: MltA; pfam03562 1191061014269 3D domain; Region: 3D; pfam06725 1191061014270 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1191061014271 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1191061014272 putative dimer interface [polypeptide binding]; other site 1191061014273 active site pocket [active] 1191061014274 putative cataytic base [active] 1191061014275 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1191061014276 homotrimer interface [polypeptide binding]; other site 1191061014277 Walker A motif; other site 1191061014278 GTP binding site [chemical binding]; other site 1191061014279 Walker B motif; other site 1191061014280 cobyric acid synthase; Provisional; Region: PRK00784 1191061014281 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1191061014282 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1191061014283 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1191061014284 catalytic triad [active] 1191061014285 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638 1191061014286 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1191061014287 Walker A/P-loop; other site 1191061014288 ATP binding site [chemical binding]; other site 1191061014289 Q-loop/lid; other site 1191061014290 ABC transporter signature motif; other site 1191061014291 Walker B; other site 1191061014292 D-loop; other site 1191061014293 H-loop/switch region; other site 1191061014294 cobalt transport protein CbiQ; Provisional; Region: PRK15485 1191061014295 cobalt transport protein CbiN; Provisional; Region: PRK02898 1191061014296 cobalt transport protein CbiM; Validated; Region: PRK08319 1191061014297 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 1191061014298 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1191061014299 active site 1191061014300 SAM binding site [chemical binding]; other site 1191061014301 homodimer interface [polypeptide binding]; other site 1191061014302 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 1191061014303 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 1191061014304 active site 1191061014305 C-terminal domain interface [polypeptide binding]; other site 1191061014306 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 1191061014307 active site 1191061014308 N-terminal domain interface [polypeptide binding]; other site 1191061014309 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 1191061014310 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1191061014311 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1191061014312 homodimer interface [polypeptide binding]; other site 1191061014313 active site 1191061014314 SAM binding site [chemical binding]; other site 1191061014315 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 1191061014316 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 1191061014317 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 1191061014318 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 1191061014319 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1191061014320 active site 1191061014321 SAM binding site [chemical binding]; other site 1191061014322 homodimer interface [polypeptide binding]; other site 1191061014323 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 1191061014324 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191061014325 S-adenosylmethionine binding site [chemical binding]; other site 1191061014326 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1191061014327 active site 1191061014328 putative homodimer interface [polypeptide binding]; other site 1191061014329 SAM binding site [chemical binding]; other site 1191061014330 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 1191061014331 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286 1191061014332 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1191061014333 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1191061014334 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1191061014335 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1191061014336 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1191061014337 catalytic triad [active] 1191061014338 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 1191061014339 Sensory domain found in PocR; Region: PocR; pfam10114 1191061014340 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1191061014341 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061014342 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061014343 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1191061014344 amphipathic channel; other site 1191061014345 Asn-Pro-Ala signature motifs; other site 1191061014346 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1191061014347 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 1191061014348 Hexamer interface [polypeptide binding]; other site 1191061014349 Putative hexagonal pore residue; other site 1191061014350 propanediol utilization protein PduB; Provisional; Region: PRK15415 1191061014351 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 1191061014352 putative hexamer interface [polypeptide binding]; other site 1191061014353 putative hexagonal pore; other site 1191061014354 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 1191061014355 putative hexamer interface [polypeptide binding]; other site 1191061014356 putative hexagonal pore; other site 1191061014357 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 1191061014358 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 1191061014359 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 1191061014360 alpha-beta subunit interface [polypeptide binding]; other site 1191061014361 alpha-gamma subunit interface [polypeptide binding]; other site 1191061014362 active site 1191061014363 substrate and K+ binding site; other site 1191061014364 K+ binding site [ion binding]; other site 1191061014365 cobalamin binding site [chemical binding]; other site 1191061014366 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 1191061014367 Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910 1191061014368 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 1191061014369 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 1191061014370 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1191061014371 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 1191061014372 Hexamer interface [polypeptide binding]; other site 1191061014373 Putative hexagonal pore residue; other site 1191061014374 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1191061014375 1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056 1191061014376 putative hexamer interface [polypeptide binding]; other site 1191061014377 putative hexagonal pore; other site 1191061014378 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 1191061014379 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1191061014380 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1191061014381 putative propanediol utilization protein PduM; Provisional; Region: PRK15428 1191061014382 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cl01889 1191061014383 Hexamer/Pentamer interface [polypeptide binding]; other site 1191061014384 central pore; other site 1191061014385 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1191061014386 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 1191061014387 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 1191061014388 putative catalytic cysteine [active] 1191061014389 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1191061014390 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 1191061014391 putative active site [active] 1191061014392 metal binding site [ion binding]; metal-binding site 1191061014393 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 1191061014394 SLBB domain; Region: SLBB; pfam10531 1191061014395 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 1191061014396 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 1191061014397 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 1191061014398 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 1191061014399 putative hexamer interface [polypeptide binding]; other site 1191061014400 putative hexagonal pore; other site 1191061014401 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 1191061014402 putative hexamer interface [polypeptide binding]; other site 1191061014403 putative hexagonal pore; other site 1191061014404 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 1191061014405 putative hexamer interface [polypeptide binding]; other site 1191061014406 putative hexagonal pore; other site 1191061014407 Ethanolamine utilisation - propanediol utilisation; Region: PduV-EutP; pfam10662 1191061014408 G1 box; other site 1191061014409 GTP/Mg2+ binding site [chemical binding]; other site 1191061014410 G2 box; other site 1191061014411 Switch I region; other site 1191061014412 G3 box; other site 1191061014413 Switch II region; other site 1191061014414 G4 box; other site 1191061014415 propionate kinase; Reviewed; Region: PRK12397 1191061014416 propionate/acetate kinase; Provisional; Region: PRK12379 1191061014417 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 1191061014418 threonine-phosphate decarboxylase; Provisional; Region: PRK08056 1191061014419 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1191061014420 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061014421 homodimer interface [polypeptide binding]; other site 1191061014422 catalytic residue [active] 1191061014423 AMIN domain; Region: AMIN; pfam11741 1191061014424 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1191061014425 active site 1191061014426 metal binding site [ion binding]; metal-binding site 1191061014427 N-acetylglutamate synthase; Validated; Region: PRK05279 1191061014428 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 1191061014429 putative feedback inhibition sensing region; other site 1191061014430 putative nucleotide binding site [chemical binding]; other site 1191061014431 putative substrate binding site [chemical binding]; other site 1191061014432 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1191061014433 Coenzyme A binding pocket [chemical binding]; other site 1191061014434 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 1191061014435 AAA domain; Region: AAA_30; pfam13604 1191061014436 Family description; Region: UvrD_C_2; pfam13538 1191061014437 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 1191061014438 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1191061014439 protease3; Provisional; Region: PRK15101 1191061014440 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1191061014441 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1191061014442 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1191061014443 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1191061014444 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 1191061014445 hypothetical protein; Provisional; Region: PRK10332 1191061014446 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 1191061014447 Protein of unknown function (DUF2509); Region: DUF2509; cl11672 1191061014448 hypothetical protein; Provisional; Region: PRK10557 1191061014449 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1191061014450 hypothetical protein; Provisional; Region: PRK10506 1191061014451 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1191061014452 active site 1191061014453 dimerization interface [polypeptide binding]; other site 1191061014454 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1191061014455 prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544 1191061014456 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 1191061014457 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1191061014458 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1191061014459 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1191061014460 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1191061014461 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1191061014462 putative active site [active] 1191061014463 Ap4A binding site [chemical binding]; other site 1191061014464 nudix motif; other site 1191061014465 putative metal binding site [ion binding]; other site 1191061014466 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 1191061014467 putative DNA-binding cleft [nucleotide binding]; other site 1191061014468 putative DNA clevage site; other site 1191061014469 molecular lever; other site 1191061014470 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1191061014471 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1191061014472 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1191061014473 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1191061014474 active site 1191061014475 catalytic tetrad [active] 1191061014476 lysophospholipid transporter LplT; Provisional; Region: PRK11195 1191061014477 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061014478 putative substrate translocation pore; other site 1191061014479 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 1191061014480 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1191061014481 putative acyl-acceptor binding pocket; other site 1191061014482 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 1191061014483 acyl-activating enzyme (AAE) consensus motif; other site 1191061014484 putative AMP binding site [chemical binding]; other site 1191061014485 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 1191061014486 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1191061014487 DNA binding site [nucleotide binding] 1191061014488 domain linker motif; other site 1191061014489 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1191061014490 dimerization interface (closed form) [polypeptide binding]; other site 1191061014491 ligand binding site [chemical binding]; other site 1191061014492 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1191061014493 Coenzyme A binding pocket [chemical binding]; other site 1191061014494 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 1191061014495 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1191061014496 DNA-binding site [nucleotide binding]; DNA binding site 1191061014497 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1191061014498 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1191061014499 beta-galactosidase; Region: BGL; TIGR03356 1191061014500 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1191061014501 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1191061014502 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1191061014503 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1191061014504 DNA binding site [nucleotide binding] 1191061014505 domain linker motif; other site 1191061014506 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1191061014507 dimerization interface (closed form) [polypeptide binding]; other site 1191061014508 ligand binding site [chemical binding]; other site 1191061014509 diaminopimelate decarboxylase; Provisional; Region: PRK11165 1191061014510 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1191061014511 active site 1191061014512 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1191061014513 substrate binding site [chemical binding]; other site 1191061014514 catalytic residues [active] 1191061014515 dimer interface [polypeptide binding]; other site 1191061014516 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1191061014517 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061014518 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1191061014519 dimerization interface [polypeptide binding]; other site 1191061014520 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1191061014521 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1191061014522 putative fimbrial outer membrane usher protein; Provisional; Region: PRK15304 1191061014523 PapC N-terminal domain; Region: PapC_N; pfam13954 1191061014524 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1191061014525 PapC C-terminal domain; Region: PapC_C; pfam13953 1191061014526 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 1191061014527 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1191061014528 aspartate racemase; Region: asp_race; TIGR00035 1191061014529 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1191061014530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061014531 dimer interface [polypeptide binding]; other site 1191061014532 conserved gate region; other site 1191061014533 putative PBP binding loops; other site 1191061014534 ABC-ATPase subunit interface; other site 1191061014535 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1191061014536 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061014537 dimer interface [polypeptide binding]; other site 1191061014538 conserved gate region; other site 1191061014539 putative PBP binding loops; other site 1191061014540 ABC-ATPase subunit interface; other site 1191061014541 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1191061014542 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1191061014543 Walker A/P-loop; other site 1191061014544 ATP binding site [chemical binding]; other site 1191061014545 Q-loop/lid; other site 1191061014546 ABC transporter signature motif; other site 1191061014547 Walker B; other site 1191061014548 D-loop; other site 1191061014549 H-loop/switch region; other site 1191061014550 TOBE domain; Region: TOBE_2; pfam08402 1191061014551 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1191061014552 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1191061014553 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1191061014554 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1191061014555 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 1191061014556 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1191061014557 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1191061014558 substrate binding [chemical binding]; other site 1191061014559 active site 1191061014560 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1191061014561 galactoside permease; Reviewed; Region: lacY; PRK09528 1191061014562 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1191061014563 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1191061014564 DNA binding site [nucleotide binding] 1191061014565 domain linker motif; other site 1191061014566 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 1191061014567 putative dimerization interface [polypeptide binding]; other site 1191061014568 putative ligand binding site [chemical binding]; other site 1191061014569 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1191061014570 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061014571 putative substrate translocation pore; other site 1191061014572 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061014573 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 1191061014574 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1191061014575 NADP binding site [chemical binding]; other site 1191061014576 homodimer interface [polypeptide binding]; other site 1191061014577 active site 1191061014578 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1191061014579 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1191061014580 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 1191061014581 putative acyltransferase; Provisional; Region: PRK05790 1191061014582 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1191061014583 dimer interface [polypeptide binding]; other site 1191061014584 active site 1191061014585 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061014586 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061014587 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1191061014588 dimerization interface [polypeptide binding]; other site 1191061014589 Predicted membrane protein [Function unknown]; Region: COG4125 1191061014590 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1191061014591 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1191061014592 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1191061014593 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1191061014594 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1191061014595 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1191061014596 active site 1191061014597 catalytic tetrad [active] 1191061014598 PilZ domain; Region: PilZ; pfam07238 1191061014599 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1191061014600 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1191061014601 DNA binding residues [nucleotide binding] 1191061014602 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1191061014603 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1191061014604 putative major fimbrial protein SthE; Provisional; Region: PRK15292 1191061014605 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1191061014606 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1191061014607 PapC N-terminal domain; Region: PapC_N; pfam13954 1191061014608 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1191061014609 PapC C-terminal domain; Region: PapC_C; pfam13953 1191061014610 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1191061014611 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1191061014612 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1191061014613 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1191061014614 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1191061014615 putative DNA binding site [nucleotide binding]; other site 1191061014616 dimerization interface [polypeptide binding]; other site 1191061014617 putative Zn2+ binding site [ion binding]; other site 1191061014618 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1191061014619 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 1191061014620 EamA-like transporter family; Region: EamA; pfam00892 1191061014621 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1191061014622 EamA-like transporter family; Region: EamA; pfam00892 1191061014623 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1191061014624 MarR family; Region: MarR; pfam01047 1191061014625 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1191061014626 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1191061014627 putative DNA binding site [nucleotide binding]; other site 1191061014628 putative Zn2+ binding site [ion binding]; other site 1191061014629 AsnC family; Region: AsnC_trans_reg; pfam01037 1191061014630 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1191061014631 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1191061014632 Coenzyme A binding pocket [chemical binding]; other site 1191061014633 Uncharacterized conserved protein [Function unknown]; Region: COG3592 1191061014634 multidrug resistance protein MdtN; Provisional; Region: PRK10476 1191061014635 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1191061014636 HlyD family secretion protein; Region: HlyD_3; pfam13437 1191061014637 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 1191061014638 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1191061014639 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 1191061014640 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1191061014641 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1191061014642 DNA binding residues [nucleotide binding] 1191061014643 dimerization interface [polypeptide binding]; other site 1191061014644 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1191061014645 acetoin reductases; Region: 23BDH; TIGR02415 1191061014646 NAD(P) binding site [chemical binding]; other site 1191061014647 active site 1191061014648 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061014649 putative substrate translocation pore; other site 1191061014650 POT family; Region: PTR2; cl17359 1191061014651 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 1191061014652 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1191061014653 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1191061014654 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1191061014655 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1191061014656 D-xylulose kinases, subgroup 3; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_3; cd07811 1191061014657 putative N- and C-terminal domain interface [polypeptide binding]; other site 1191061014658 putative active site [active] 1191061014659 putative MgATP binding site [chemical binding]; other site 1191061014660 catalytic site [active] 1191061014661 metal binding site [ion binding]; metal-binding site 1191061014662 putative xylulose binding site [chemical binding]; other site 1191061014663 putative homodimer interface [polypeptide binding]; other site 1191061014664 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1191061014665 intersubunit interface [polypeptide binding]; other site 1191061014666 active site 1191061014667 catalytic residue [active] 1191061014668 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1191061014669 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1191061014670 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1191061014671 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1191061014672 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1191061014673 substrate binding site [chemical binding]; other site 1191061014674 hexamer interface [polypeptide binding]; other site 1191061014675 metal binding site [ion binding]; metal-binding site 1191061014676 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1191061014677 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1191061014678 substrate binding site [chemical binding]; other site 1191061014679 dimer interface [polypeptide binding]; other site 1191061014680 ATP binding site [chemical binding]; other site 1191061014681 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1191061014682 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061014683 putative substrate translocation pore; other site 1191061014684 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1191061014685 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1191061014686 active site 1191061014687 metal binding site [ion binding]; metal-binding site 1191061014688 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1191061014689 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1191061014690 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1191061014691 acyl-activating enzyme (AAE) consensus motif; other site 1191061014692 acyl-activating enzyme (AAE) consensus motif; other site 1191061014693 putative AMP binding site [chemical binding]; other site 1191061014694 putative active site [active] 1191061014695 putative CoA binding site [chemical binding]; other site 1191061014696 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 1191061014697 Coenzyme A transferase; Region: CoA_trans; smart00882 1191061014698 Coenzyme A transferase; Region: CoA_trans; cl17247 1191061014699 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1191061014700 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1191061014701 NAD(P) binding site [chemical binding]; other site 1191061014702 homotetramer interface [polypeptide binding]; other site 1191061014703 homodimer interface [polypeptide binding]; other site 1191061014704 active site 1191061014705 putative acyltransferase; Provisional; Region: PRK05790 1191061014706 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1191061014707 dimer interface [polypeptide binding]; other site 1191061014708 active site 1191061014709 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1191061014710 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061014711 putative substrate translocation pore; other site 1191061014712 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1191061014713 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061014714 putative substrate translocation pore; other site 1191061014715 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1191061014716 glycerate kinase; Region: TIGR00045 1191061014717 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1191061014718 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1191061014719 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1191061014720 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061014721 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1191061014722 putative substrate translocation pore; other site 1191061014723 Predicted kinase [General function prediction only]; Region: COG0645 1191061014724 AAA domain; Region: AAA_17; pfam13207 1191061014725 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 1191061014726 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061014727 putative substrate translocation pore; other site 1191061014728 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1191061014729 ArsC family; Region: ArsC; pfam03960 1191061014730 catalytic residues [active] 1191061014731 arsenical pump membrane protein; Provisional; Region: PRK15445 1191061014732 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1191061014733 transmembrane helices; other site 1191061014734 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1191061014735 dimerization interface [polypeptide binding]; other site 1191061014736 putative DNA binding site [nucleotide binding]; other site 1191061014737 putative Zn2+ binding site [ion binding]; other site 1191061014738 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061014739 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1191061014740 putative substrate translocation pore; other site 1191061014741 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1191061014742 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1191061014743 active site 1191061014744 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1191061014745 catalytic tetrad [active] 1191061014746 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1191061014747 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191061014748 active site 1191061014749 phosphorylation site [posttranslational modification] 1191061014750 intermolecular recognition site; other site 1191061014751 dimerization interface [polypeptide binding]; other site 1191061014752 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1191061014753 DNA binding site [nucleotide binding] 1191061014754 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1191061014755 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1191061014756 dimerization interface [polypeptide binding]; other site 1191061014757 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191061014758 dimer interface [polypeptide binding]; other site 1191061014759 phosphorylation site [posttranslational modification] 1191061014760 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191061014761 ATP binding site [chemical binding]; other site 1191061014762 Mg2+ binding site [ion binding]; other site 1191061014763 G-X-G motif; other site 1191061014764 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1191061014765 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1191061014766 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1191061014767 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810 1191061014768 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1191061014769 catalytic site [active] 1191061014770 Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; pfam10137 1191061014771 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1191061014772 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1191061014773 active site 1191061014774 catalytic tetrad [active] 1191061014775 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1191061014776 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1191061014777 active site 1191061014778 catalytic tetrad [active] 1191061014779 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061014780 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061014781 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1191061014782 putative effector binding pocket; other site 1191061014783 putative dimerization interface [polypeptide binding]; other site 1191061014784 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1191061014785 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1191061014786 NAD(P) binding site [chemical binding]; other site 1191061014787 putative active site [active] 1191061014788 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1191061014789 integrase; Provisional; Region: PRK09692 1191061014790 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1191061014791 active site 1191061014792 Int/Topo IB signature motif; other site 1191061014793 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1191061014794 Peptidase family M23; Region: Peptidase_M23; pfam01551 1191061014795 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061014796 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061014797 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1191061014798 dimerization interface [polypeptide binding]; other site 1191061014799 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 1191061014800 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 1191061014801 Flavoprotein; Region: Flavoprotein; pfam02441 1191061014802 Protein of unknown function (DUF554); Region: DUF554; pfam04474 1191061014803 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 1191061014804 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1191061014805 active site 1191061014806 metal binding site [ion binding]; metal-binding site 1191061014807 nudix motif; other site 1191061014808 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 1191061014809 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1191061014810 dimer interface [polypeptide binding]; other site 1191061014811 putative anticodon binding site; other site 1191061014812 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1191061014813 motif 1; other site 1191061014814 active site 1191061014815 motif 2; other site 1191061014816 motif 3; other site 1191061014817 peptide chain release factor 2; Provisional; Region: PRK08787 1191061014818 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1191061014819 RF-1 domain; Region: RF-1; pfam00472 1191061014820 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 1191061014821 DHH family; Region: DHH; pfam01368 1191061014822 DHHA1 domain; Region: DHHA1; pfam02272 1191061014823 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 1191061014824 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1191061014825 dimerization domain [polypeptide binding]; other site 1191061014826 dimer interface [polypeptide binding]; other site 1191061014827 catalytic residues [active] 1191061014828 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1191061014829 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1191061014830 active site 1191061014831 Int/Topo IB signature motif; other site 1191061014832 flavodoxin FldB; Provisional; Region: PRK12359 1191061014833 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 1191061014834 hypothetical protein; Provisional; Region: PRK10878 1191061014835 putative global regulator; Reviewed; Region: PRK09559 1191061014836 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1191061014837 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1191061014838 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191061014839 Walker A motif; other site 1191061014840 ATP binding site [chemical binding]; other site 1191061014841 Walker B motif; other site 1191061014842 arginine finger; other site 1191061014843 Transcriptional antiterminator [Transcription]; Region: COG3933 1191061014844 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1191061014845 active site 1191061014846 active pocket/dimerization site; other site 1191061014847 phosphorylation site [posttranslational modification] 1191061014848 PRD domain; Region: PRD; pfam00874 1191061014849 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1191061014850 active pocket/dimerization site; other site 1191061014851 active site 1191061014852 phosphorylation site [posttranslational modification] 1191061014853 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1191061014854 active site 1191061014855 phosphorylation site [posttranslational modification] 1191061014856 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 1191061014857 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 1191061014858 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1191061014859 Protein of unknown function (DUF1341); Region: DUF1341; cl06211 1191061014860 hemolysin; Provisional; Region: PRK15087 1191061014861 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1191061014862 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 1191061014863 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1191061014864 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1191061014865 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1191061014866 putative active site [active] 1191061014867 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1191061014868 beta-galactosidase; Region: BGL; TIGR03356 1191061014869 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 1191061014870 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1191061014871 catalytic residues [active] 1191061014872 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 1191061014873 classical (c) SDRs; Region: SDR_c; cd05233 1191061014874 NAD(P) binding site [chemical binding]; other site 1191061014875 active site 1191061014876 glycine dehydrogenase; Provisional; Region: PRK05367 1191061014877 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1191061014878 tetramer interface [polypeptide binding]; other site 1191061014879 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061014880 catalytic residue [active] 1191061014881 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1191061014882 tetramer interface [polypeptide binding]; other site 1191061014883 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061014884 catalytic residue [active] 1191061014885 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1191061014886 lipoyl attachment site [posttranslational modification]; other site 1191061014887 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1191061014888 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1191061014889 oxidoreductase; Provisional; Region: PRK08013 1191061014890 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1191061014891 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 1191061014892 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 1191061014893 proline aminopeptidase P II; Provisional; Region: PRK10879 1191061014894 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 1191061014895 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1191061014896 active site 1191061014897 hypothetical protein; Reviewed; Region: PRK01736 1191061014898 Cell division protein ZapA; Region: ZapA; cl01146 1191061014899 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 1191061014900 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1191061014901 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1191061014902 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1191061014903 ligand binding site [chemical binding]; other site 1191061014904 NAD binding site [chemical binding]; other site 1191061014905 tetramer interface [polypeptide binding]; other site 1191061014906 catalytic site [active] 1191061014907 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1191061014908 L-serine binding site [chemical binding]; other site 1191061014909 ACT domain interface; other site 1191061014910 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1191061014911 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1191061014912 active site 1191061014913 dimer interface [polypeptide binding]; other site 1191061014914 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1191061014915 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061014916 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 1191061014917 putative dimerization interface [polypeptide binding]; other site 1191061014918 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1191061014919 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1191061014920 active site 1191061014921 substrate binding site [chemical binding]; other site 1191061014922 coenzyme B12 binding site [chemical binding]; other site 1191061014923 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1191061014924 B12 binding site [chemical binding]; other site 1191061014925 cobalt ligand [ion binding]; other site 1191061014926 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1191061014927 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1191061014928 Walker A; other site 1191061014929 methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423 1191061014930 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1191061014931 substrate binding site [chemical binding]; other site 1191061014932 oxyanion hole (OAH) forming residues; other site 1191061014933 trimer interface [polypeptide binding]; other site 1191061014934 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1191061014935 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1191061014936 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1191061014937 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061014938 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061014939 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1191061014940 dimerization interface [polypeptide binding]; other site 1191061014941 oxidative stress defense protein; Provisional; Region: PRK11087 1191061014942 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1191061014943 arginine exporter protein; Provisional; Region: PRK09304 1191061014944 mechanosensitive channel MscS; Provisional; Region: PRK10334 1191061014945 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1191061014946 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1191061014947 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 1191061014948 active site 1191061014949 intersubunit interface [polypeptide binding]; other site 1191061014950 zinc binding site [ion binding]; other site 1191061014951 Na+ binding site [ion binding]; other site 1191061014952 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1191061014953 Phosphoglycerate kinase; Region: PGK; pfam00162 1191061014954 substrate binding site [chemical binding]; other site 1191061014955 hinge regions; other site 1191061014956 ADP binding site [chemical binding]; other site 1191061014957 catalytic site [active] 1191061014958 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 1191061014959 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1191061014960 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1191061014961 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 1191061014962 trimer interface [polypeptide binding]; other site 1191061014963 putative Zn binding site [ion binding]; other site 1191061014964 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1191061014965 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1191061014966 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1191061014967 Walker A/P-loop; other site 1191061014968 ATP binding site [chemical binding]; other site 1191061014969 Q-loop/lid; other site 1191061014970 ABC transporter signature motif; other site 1191061014971 Walker B; other site 1191061014972 D-loop; other site 1191061014973 H-loop/switch region; other site 1191061014974 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1191061014975 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1191061014976 Walker A/P-loop; other site 1191061014977 ATP binding site [chemical binding]; other site 1191061014978 Q-loop/lid; other site 1191061014979 ABC transporter signature motif; other site 1191061014980 Walker B; other site 1191061014981 D-loop; other site 1191061014982 H-loop/switch region; other site 1191061014983 transketolase; Reviewed; Region: PRK12753 1191061014984 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1191061014985 TPP-binding site [chemical binding]; other site 1191061014986 dimer interface [polypeptide binding]; other site 1191061014987 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1191061014988 PYR/PP interface [polypeptide binding]; other site 1191061014989 dimer interface [polypeptide binding]; other site 1191061014990 TPP binding site [chemical binding]; other site 1191061014991 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1191061014992 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1191061014993 agmatinase; Region: agmatinase; TIGR01230 1191061014994 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1191061014995 oligomer interface [polypeptide binding]; other site 1191061014996 putative active site [active] 1191061014997 Mn binding site [ion binding]; other site 1191061014998 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 1191061014999 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1191061015000 dimer interface [polypeptide binding]; other site 1191061015001 active site 1191061015002 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1191061015003 catalytic residues [active] 1191061015004 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1191061015005 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1191061015006 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1191061015007 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1191061015008 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1191061015009 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1191061015010 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061015011 putative substrate translocation pore; other site 1191061015012 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061015013 hypothetical protein; Provisional; Region: PRK04860 1191061015014 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1191061015015 DNA-specific endonuclease I; Provisional; Region: PRK15137 1191061015016 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 1191061015017 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1191061015018 RNA methyltransferase, RsmE family; Region: TIGR00046 1191061015019 glutathione synthetase; Provisional; Region: PRK05246 1191061015020 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1191061015021 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1191061015022 hypothetical protein; Validated; Region: PRK00228 1191061015023 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1191061015024 potential frameshift: common BLAST hit: gi|375257348|ref|YP_005016518.1| DNA-binding transcriptional regulator CsgD 1191061015025 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 1191061015026 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1191061015027 DNA binding residues [nucleotide binding] 1191061015028 dimerization interface [polypeptide binding]; other site 1191061015029 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 1191061015030 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1191061015031 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 1191061015032 Walker A motif; other site 1191061015033 ATP binding site [chemical binding]; other site 1191061015034 Walker B motif; other site 1191061015035 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 1191061015036 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1191061015037 catalytic residue [active] 1191061015038 YGGT family; Region: YGGT; pfam02325 1191061015039 Predicted integral membrane protein [Function unknown]; Region: COG0762 1191061015040 hypothetical protein; Validated; Region: PRK05090 1191061015041 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1191061015042 active site 1191061015043 dimerization interface [polypeptide binding]; other site 1191061015044 HemN family oxidoreductase; Provisional; Region: PRK05660 1191061015045 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1191061015046 FeS/SAM binding site; other site 1191061015047 HemN C-terminal domain; Region: HemN_C; pfam06969 1191061015048 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1191061015049 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 1191061015050 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1191061015051 DctM-like transporters; Region: DctM; pfam06808 1191061015052 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 1191061015053 hypothetical protein; Provisional; Region: PRK10626 1191061015054 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 1191061015055 hypothetical protein; Provisional; Region: PRK11702 1191061015056 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1191061015057 adenine DNA glycosylase; Provisional; Region: PRK10880 1191061015058 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1191061015059 minor groove reading motif; other site 1191061015060 helix-hairpin-helix signature motif; other site 1191061015061 substrate binding pocket [chemical binding]; other site 1191061015062 active site 1191061015063 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1191061015064 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1191061015065 DNA binding and oxoG recognition site [nucleotide binding] 1191061015066 oxidative damage protection protein; Provisional; Region: PRK05408 1191061015067 murein transglycosylase C; Provisional; Region: mltC; PRK11671 1191061015068 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 1191061015069 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1191061015070 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1191061015071 catalytic residue [active] 1191061015072 nucleoside transporter; Region: 2A0110; TIGR00889 1191061015073 ornithine decarboxylase; Provisional; Region: PRK13578 1191061015074 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1191061015075 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1191061015076 homodimer interface [polypeptide binding]; other site 1191061015077 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061015078 catalytic residue [active] 1191061015079 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1191061015080 Protein of unknown function (DUF554); Region: DUF554; pfam04474 1191061015081 Resolvase, N terminal domain; Region: Resolvase; pfam00239 1191061015082 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1191061015083 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1191061015084 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1191061015085 P-loop; other site 1191061015086 Magnesium ion binding site [ion binding]; other site 1191061015087 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1191061015088 Magnesium ion binding site [ion binding]; other site 1191061015089 Winged helix-turn-helix DNA-binding; Region: HTH_35; cl17423 1191061015090 Domain of unknown function (DUF1837); Region: DUF1837; pfam08878 1191061015091 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1191061015092 ATP binding site [chemical binding]; other site 1191061015093 putative Mg++ binding site [ion binding]; other site 1191061015094 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1191061015095 nucleotide binding region [chemical binding]; other site 1191061015096 ATP-binding site [chemical binding]; other site 1191061015097 Fic family protein [Function unknown]; Region: COG3177 1191061015098 Fic/DOC family; Region: Fic; pfam02661 1191061015099 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1191061015100 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1191061015101 transmembrane helices; other site 1191061015102 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1191061015103 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1191061015104 dimer interface [polypeptide binding]; other site 1191061015105 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061015106 catalytic residue [active] 1191061015107 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 1191061015108 FOG: CBS domain [General function prediction only]; Region: COG0517 1191061015109 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 1191061015110 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1191061015111 homodimer interface [polypeptide binding]; other site 1191061015112 substrate-cofactor binding pocket; other site 1191061015113 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061015114 catalytic residue [active] 1191061015115 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061015116 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061015117 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 1191061015118 putative effector binding pocket; other site 1191061015119 putative dimerization interface [polypeptide binding]; other site 1191061015120 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 1191061015121 putative NAD(P) binding site [chemical binding]; other site 1191061015122 homodimer interface [polypeptide binding]; other site 1191061015123 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1191061015124 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1191061015125 Autotransporter beta-domain; Region: Autotransporter; smart00869 1191061015126 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1191061015127 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1191061015128 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061015129 homodimer interface [polypeptide binding]; other site 1191061015130 catalytic residue [active] 1191061015131 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 1191061015132 CHAP domain; Region: CHAP; pfam05257 1191061015133 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1191061015134 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1191061015135 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1191061015136 Thioredoxin; Region: Thioredoxin_4; cl17273 1191061015137 putative S-transferase; Provisional; Region: PRK11752 1191061015138 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1191061015139 C-terminal domain interface [polypeptide binding]; other site 1191061015140 GSH binding site (G-site) [chemical binding]; other site 1191061015141 dimer interface [polypeptide binding]; other site 1191061015142 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 1191061015143 dimer interface [polypeptide binding]; other site 1191061015144 N-terminal domain interface [polypeptide binding]; other site 1191061015145 active site 1191061015146 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 1191061015147 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1191061015148 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1191061015149 hypothetical protein; Provisional; Region: PRK05208 1191061015150 biopolymer transport protein ExbD; Provisional; Region: PRK11267 1191061015151 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1191061015152 biopolymer transport protein ExbB; Provisional; Region: PRK10414 1191061015153 cystathionine beta-lyase; Provisional; Region: PRK08114 1191061015154 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1191061015155 homodimer interface [polypeptide binding]; other site 1191061015156 substrate-cofactor binding pocket; other site 1191061015157 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061015158 catalytic residue [active] 1191061015159 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1191061015160 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1191061015161 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1191061015162 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1191061015163 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061015164 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061015165 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1191061015166 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1191061015167 dimer interface [polypeptide binding]; other site 1191061015168 active site 1191061015169 metal binding site [ion binding]; metal-binding site 1191061015170 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1191061015171 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1191061015172 active site 1191061015173 catalytic tetrad [active] 1191061015174 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1191061015175 nucleotide binding site/active site [active] 1191061015176 hypothetical protein; Provisional; Region: PRK01254 1191061015177 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 1191061015178 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 1191061015179 FtsI repressor; Provisional; Region: PRK10883 1191061015180 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1191061015181 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1191061015182 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 1191061015183 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1191061015184 putative acyl-acceptor binding pocket; other site 1191061015185 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 1191061015186 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1191061015187 CAP-like domain; other site 1191061015188 active site 1191061015189 primary dimer interface [polypeptide binding]; other site 1191061015190 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1191061015191 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061015192 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 1191061015193 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 1191061015194 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 1191061015195 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191061015196 active site 1191061015197 phosphorylation site [posttranslational modification] 1191061015198 intermolecular recognition site; other site 1191061015199 dimerization interface [polypeptide binding]; other site 1191061015200 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1191061015201 DNA binding site [nucleotide binding] 1191061015202 sensor protein QseC; Provisional; Region: PRK10337 1191061015203 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191061015204 dimer interface [polypeptide binding]; other site 1191061015205 phosphorylation site [posttranslational modification] 1191061015206 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191061015207 ATP binding site [chemical binding]; other site 1191061015208 Mg2+ binding site [ion binding]; other site 1191061015209 G-X-G motif; other site 1191061015210 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1191061015211 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1191061015212 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 1191061015213 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191061015214 ATP binding site [chemical binding]; other site 1191061015215 Mg2+ binding site [ion binding]; other site 1191061015216 G-X-G motif; other site 1191061015217 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1191061015218 anchoring element; other site 1191061015219 dimer interface [polypeptide binding]; other site 1191061015220 ATP binding site [chemical binding]; other site 1191061015221 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1191061015222 active site 1191061015223 metal binding site [ion binding]; metal-binding site 1191061015224 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1191061015225 esterase YqiA; Provisional; Region: PRK11071 1191061015226 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1191061015227 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1191061015228 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1191061015229 active site 1191061015230 metal binding site [ion binding]; metal-binding site 1191061015231 hexamer interface [polypeptide binding]; other site 1191061015232 putative dehydrogenase; Provisional; Region: PRK11039 1191061015233 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 1191061015234 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1191061015235 dimer interface [polypeptide binding]; other site 1191061015236 ADP-ribose binding site [chemical binding]; other site 1191061015237 active site 1191061015238 nudix motif; other site 1191061015239 metal binding site [ion binding]; metal-binding site 1191061015240 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 1191061015241 hypothetical protein; Provisional; Region: PRK11653 1191061015242 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1191061015243 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1191061015244 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1191061015245 putative active site [active] 1191061015246 metal binding site [ion binding]; metal-binding site 1191061015247 zinc transporter ZupT; Provisional; Region: PRK04201 1191061015248 ZIP Zinc transporter; Region: Zip; pfam02535 1191061015249 Fimbrial protein; Region: Fimbrial; cl01416 1191061015250 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1191061015251 PapC N-terminal domain; Region: PapC_N; pfam13954 1191061015252 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1191061015253 PapC C-terminal domain; Region: PapC_C; pfam13953 1191061015254 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1191061015255 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1191061015256 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1191061015257 Fimbrial protein; Region: Fimbrial; pfam00419 1191061015258 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 1191061015259 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1191061015260 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 1191061015261 Glycogen synthesis protein; Region: GlgS; cl11663 1191061015262 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 1191061015263 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1191061015264 putative ribose interaction site [chemical binding]; other site 1191061015265 putative ADP binding site [chemical binding]; other site 1191061015266 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1191061015267 active site 1191061015268 nucleotide binding site [chemical binding]; other site 1191061015269 HIGH motif; other site 1191061015270 KMSKS motif; other site 1191061015271 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 1191061015272 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1191061015273 metal binding triad; other site 1191061015274 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1191061015275 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1191061015276 metal binding triad; other site 1191061015277 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1191061015278 Uncharacterized conserved protein [Function unknown]; Region: COG3025 1191061015279 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 1191061015280 putative active site [active] 1191061015281 putative metal binding residues [ion binding]; other site 1191061015282 signature motif; other site 1191061015283 putative triphosphate binding site [ion binding]; other site 1191061015284 SH3 domain-containing protein; Provisional; Region: PRK10884 1191061015285 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1191061015286 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 1191061015287 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1191061015288 active site 1191061015289 NTP binding site [chemical binding]; other site 1191061015290 metal binding triad [ion binding]; metal-binding site 1191061015291 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1191061015292 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1191061015293 Zn2+ binding site [ion binding]; other site 1191061015294 Mg2+ binding site [ion binding]; other site 1191061015295 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1191061015296 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1191061015297 homooctamer interface [polypeptide binding]; other site 1191061015298 active site 1191061015299 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1191061015300 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 1191061015301 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1191061015302 alpha-gamma subunit interface [polypeptide binding]; other site 1191061015303 beta-gamma subunit interface [polypeptide binding]; other site 1191061015304 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1191061015305 gamma-beta subunit interface [polypeptide binding]; other site 1191061015306 alpha-beta subunit interface [polypeptide binding]; other site 1191061015307 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1191061015308 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1191061015309 subunit interactions [polypeptide binding]; other site 1191061015310 active site 1191061015311 flap region; other site 1191061015312 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 1191061015313 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1191061015314 dimer interface [polypeptide binding]; other site 1191061015315 catalytic residues [active] 1191061015316 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1191061015317 UreF; Region: UreF; pfam01730 1191061015318 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1191061015319 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1191061015320 UGMP family protein; Validated; Region: PRK09604 1191061015321 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1191061015322 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1191061015323 DNA primase; Validated; Region: dnaG; PRK05667 1191061015324 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1191061015325 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1191061015326 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1191061015327 active site 1191061015328 metal binding site [ion binding]; metal-binding site 1191061015329 interdomain interaction site; other site 1191061015330 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1191061015331 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 1191061015332 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1191061015333 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1191061015334 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1191061015335 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1191061015336 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1191061015337 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1191061015338 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1191061015339 DNA binding residues [nucleotide binding] 1191061015340 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1191061015341 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1191061015342 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 1191061015343 active site 1191061015344 SUMO-1 interface [polypeptide binding]; other site 1191061015345 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 1191061015346 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 1191061015347 PAS domain; Region: PAS; smart00091 1191061015348 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191061015349 Walker A motif; other site 1191061015350 ATP binding site [chemical binding]; other site 1191061015351 Walker B motif; other site 1191061015352 arginine finger; other site 1191061015353 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1191061015354 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1191061015355 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1191061015356 dimer interface [polypeptide binding]; other site 1191061015357 active site 1191061015358 metal binding site [ion binding]; metal-binding site 1191061015359 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 1191061015360 Dak1 domain; Region: Dak1; pfam02733 1191061015361 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 1191061015362 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 1191061015363 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 1191061015364 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1191061015365 regulatory protein interface [polypeptide binding]; other site 1191061015366 active site 1191061015367 regulatory phosphorylation site [posttranslational modification]; other site 1191061015368 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1191061015369 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1191061015370 dihydroxyacetone kinase, ATP-dependent; Region: dak_ATP; TIGR02361 1191061015371 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 1191061015372 DAK2 domain; Region: Dak2; pfam02734 1191061015373 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1191061015374 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1191061015375 FAD binding pocket [chemical binding]; other site 1191061015376 FAD binding motif [chemical binding]; other site 1191061015377 phosphate binding motif [ion binding]; other site 1191061015378 NAD binding pocket [chemical binding]; other site 1191061015379 Predicted transcriptional regulators [Transcription]; Region: COG1695 1191061015380 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1191061015381 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 1191061015382 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1191061015383 inhibitor-cofactor binding pocket; inhibition site 1191061015384 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061015385 catalytic residue [active] 1191061015386 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 1191061015387 dimer interface [polypeptide binding]; other site 1191061015388 putative tRNA-binding site [nucleotide binding]; other site 1191061015389 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 1191061015390 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1191061015391 DNA binding site [nucleotide binding] 1191061015392 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1191061015393 putative dimerization interface [polypeptide binding]; other site 1191061015394 putative ligand binding site [chemical binding]; other site 1191061015395 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 1191061015396 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1191061015397 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1191061015398 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1191061015399 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 1191061015400 Domain of unknown function (DUF386); Region: DUF386; cl01047 1191061015401 inner membrane transporter YjeM; Provisional; Region: PRK15238 1191061015402 inner membrane transporter YjeM; Provisional; Region: PRK15238 1191061015403 alpha-glucosidase; Provisional; Region: PRK10137 1191061015404 Protein of unknown function, DUF608; Region: DUF608; pfam04685 1191061015405 Trehalase; Region: Trehalase; cl17346 1191061015406 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 1191061015407 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 1191061015408 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1191061015409 putative active site; other site 1191061015410 catalytic residue [active] 1191061015411 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 1191061015412 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 1191061015413 ligand binding site [chemical binding]; other site 1191061015414 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1191061015415 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1191061015416 TM-ABC transporter signature motif; other site 1191061015417 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1191061015418 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1191061015419 TM-ABC transporter signature motif; other site 1191061015420 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 1191061015421 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1191061015422 Walker A/P-loop; other site 1191061015423 ATP binding site [chemical binding]; other site 1191061015424 Q-loop/lid; other site 1191061015425 ABC transporter signature motif; other site 1191061015426 Walker B; other site 1191061015427 D-loop; other site 1191061015428 H-loop/switch region; other site 1191061015429 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1191061015430 transcriptional regulator LsrR; Provisional; Region: PRK15418 1191061015431 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1191061015432 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 1191061015433 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 1191061015434 putative N- and C-terminal domain interface [polypeptide binding]; other site 1191061015435 putative active site [active] 1191061015436 putative MgATP binding site [chemical binding]; other site 1191061015437 catalytic site [active] 1191061015438 metal binding site [ion binding]; metal-binding site 1191061015439 putative carbohydrate binding site [chemical binding]; other site 1191061015440 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1191061015441 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1191061015442 active site 1191061015443 FMN binding site [chemical binding]; other site 1191061015444 2,4-decadienoyl-CoA binding site; other site 1191061015445 catalytic residue [active] 1191061015446 4Fe-4S cluster binding site [ion binding]; other site 1191061015447 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1191061015448 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1191061015449 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 1191061015450 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191061015451 S-adenosylmethionine binding site [chemical binding]; other site 1191061015452 putative symporter YagG; Provisional; Region: PRK09669 1191061015453 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1191061015454 potential frameshift: common BLAST hit: gi|375257476|ref|YP_005016646.1| AraC family transcriptional regulator 1191061015455 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061015456 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1191061015457 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061015458 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1191061015459 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1191061015460 inhibitor binding site; inhibition site 1191061015461 active site 1191061015462 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 1191061015463 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1191061015464 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1191061015465 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1191061015466 serine/threonine transporter SstT; Provisional; Region: PRK13628 1191061015467 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1191061015468 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 1191061015469 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1191061015470 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1191061015471 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1191061015472 Glucuronate isomerase; Region: UxaC; pfam02614 1191061015473 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1191061015474 D-galactonate transporter; Region: 2A0114; TIGR00893 1191061015475 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061015476 putative substrate translocation pore; other site 1191061015477 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 1191061015478 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1191061015479 DNA-binding site [nucleotide binding]; DNA binding site 1191061015480 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1191061015481 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1191061015482 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1191061015483 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 1191061015484 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 1191061015485 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 1191061015486 Predicted membrane protein [Function unknown]; Region: COG5393 1191061015487 YqjK-like protein; Region: YqjK; pfam13997 1191061015488 Predicted membrane protein [Function unknown]; Region: COG2259 1191061015489 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1191061015490 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1191061015491 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1191061015492 putative dimer interface [polypeptide binding]; other site 1191061015493 N-terminal domain interface [polypeptide binding]; other site 1191061015494 putative substrate binding pocket (H-site) [chemical binding]; other site 1191061015495 Predicted membrane protein [Function unknown]; Region: COG3152 1191061015496 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061015497 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1191061015498 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1191061015499 dimerization interface [polypeptide binding]; other site 1191061015500 Pirin-related protein [General function prediction only]; Region: COG1741 1191061015501 Pirin; Region: Pirin; pfam02678 1191061015502 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1191061015503 dimer interface [polypeptide binding]; other site 1191061015504 Glycerate kinase family; Region: Gly_kinase; cl00841 1191061015505 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 1191061015506 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1191061015507 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 1191061015508 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061015509 D-galactonate transporter; Region: 2A0114; TIGR00893 1191061015510 putative substrate translocation pore; other site 1191061015511 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1191061015512 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1191061015513 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1191061015514 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1191061015515 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1191061015516 substrate binding site [chemical binding]; other site 1191061015517 ATP binding site [chemical binding]; other site 1191061015518 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1191061015519 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1191061015520 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1191061015521 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1191061015522 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1191061015523 intersubunit interface [polypeptide binding]; other site 1191061015524 active site 1191061015525 zinc binding site [ion binding]; other site 1191061015526 Na+ binding site [ion binding]; other site 1191061015527 potential frameshift: common BLAST hit: gi|375257508|ref|YP_005016678.1| 6-phosphofructokinase 1191061015528 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1191061015529 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1191061015530 putative ATP binding site [chemical binding]; other site 1191061015531 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1191061015532 active site 1191061015533 P-loop; other site 1191061015534 phosphorylation site [posttranslational modification] 1191061015535 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1191061015536 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1191061015537 active site 1191061015538 phosphorylation site [posttranslational modification] 1191061015539 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1191061015540 dimerization domain swap beta strand [polypeptide binding]; other site 1191061015541 regulatory protein interface [polypeptide binding]; other site 1191061015542 active site 1191061015543 regulatory phosphorylation site [posttranslational modification]; other site 1191061015544 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 1191061015545 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1191061015546 active site 1191061015547 phosphorylation site [posttranslational modification] 1191061015548 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1191061015549 active site 1191061015550 P-loop; other site 1191061015551 phosphorylation site [posttranslational modification] 1191061015552 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1191061015553 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1191061015554 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 1191061015555 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 1191061015556 putative NAD(P) binding site [chemical binding]; other site 1191061015557 catalytic Zn binding site [ion binding]; other site 1191061015558 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1191061015559 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1191061015560 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1191061015561 Fic family protein [Function unknown]; Region: COG3177 1191061015562 Fic/DOC family; Region: Fic; pfam02661 1191061015563 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1191061015564 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 1191061015565 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1191061015566 putative SAM binding site [chemical binding]; other site 1191061015567 putative homodimer interface [polypeptide binding]; other site 1191061015568 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1191061015569 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 1191061015570 putative ligand binding site [chemical binding]; other site 1191061015571 hypothetical protein; Reviewed; Region: PRK12497 1191061015572 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1191061015573 dimer interface [polypeptide binding]; other site 1191061015574 active site 1191061015575 outer membrane lipoprotein; Provisional; Region: PRK11023 1191061015576 BON domain; Region: BON; pfam04972 1191061015577 BON domain; Region: BON; pfam04972 1191061015578 Predicted permease; Region: DUF318; pfam03773 1191061015579 potential frameshift: common BLAST hit: gi|375257524|ref|YP_005016694.1| NAD dependent epimerase/dehydratase family protein 1191061015580 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1191061015581 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1191061015582 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1191061015583 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1191061015584 proposed catalytic triad [active] 1191061015585 conserved cys residue [active] 1191061015586 hypothetical protein; Provisional; Region: PRK03467 1191061015587 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1191061015588 GIY-YIG motif/motif A; other site 1191061015589 putative active site [active] 1191061015590 putative metal binding site [ion binding]; other site 1191061015591 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1191061015592 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1191061015593 Coenzyme A binding pocket [chemical binding]; other site 1191061015594 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 1191061015595 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1191061015596 Peptidase family U32; Region: Peptidase_U32; pfam01136 1191061015597 putative protease; Provisional; Region: PRK15447 1191061015598 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1191061015599 hypothetical protein; Provisional; Region: PRK10508 1191061015600 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1191061015601 tryptophan permease; Provisional; Region: PRK10483 1191061015602 aromatic amino acid transport protein; Region: araaP; TIGR00837 1191061015603 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1191061015604 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1191061015605 ATP binding site [chemical binding]; other site 1191061015606 Mg++ binding site [ion binding]; other site 1191061015607 motif III; other site 1191061015608 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1191061015609 nucleotide binding region [chemical binding]; other site 1191061015610 ATP-binding site [chemical binding]; other site 1191061015611 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1191061015612 putative RNA binding site [nucleotide binding]; other site 1191061015613 lipoprotein NlpI; Provisional; Region: PRK11189 1191061015614 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191061015615 binding surface 1191061015616 TPR motif; other site 1191061015617 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1191061015618 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1191061015619 RNase E interface [polypeptide binding]; other site 1191061015620 trimer interface [polypeptide binding]; other site 1191061015621 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1191061015622 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1191061015623 RNase E interface [polypeptide binding]; other site 1191061015624 trimer interface [polypeptide binding]; other site 1191061015625 active site 1191061015626 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1191061015627 putative nucleic acid binding region [nucleotide binding]; other site 1191061015628 G-X-X-G motif; other site 1191061015629 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1191061015630 RNA binding site [nucleotide binding]; other site 1191061015631 domain interface; other site 1191061015632 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1191061015633 16S/18S rRNA binding site [nucleotide binding]; other site 1191061015634 S13e-L30e interaction site [polypeptide binding]; other site 1191061015635 25S rRNA binding site [nucleotide binding]; other site 1191061015636 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 1191061015637 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1191061015638 RNA binding site [nucleotide binding]; other site 1191061015639 active site 1191061015640 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1191061015641 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1191061015642 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1191061015643 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 1191061015644 translation initiation factor IF-2; Region: IF-2; TIGR00487 1191061015645 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1191061015646 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1191061015647 G1 box; other site 1191061015648 putative GEF interaction site [polypeptide binding]; other site 1191061015649 GTP/Mg2+ binding site [chemical binding]; other site 1191061015650 Switch I region; other site 1191061015651 G2 box; other site 1191061015652 G3 box; other site 1191061015653 Switch II region; other site 1191061015654 G4 box; other site 1191061015655 G5 box; other site 1191061015656 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1191061015657 Translation-initiation factor 2; Region: IF-2; pfam11987 1191061015658 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1191061015659 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1191061015660 NusA N-terminal domain; Region: NusA_N; pfam08529 1191061015661 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1191061015662 RNA binding site [nucleotide binding]; other site 1191061015663 homodimer interface [polypeptide binding]; other site 1191061015664 NusA-like KH domain; Region: KH_5; pfam13184 1191061015665 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1191061015666 G-X-X-G motif; other site 1191061015667 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1191061015668 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1191061015669 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1191061015670 hypothetical protein; Provisional; Region: PRK14641 1191061015671 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1191061015672 putative oligomer interface [polypeptide binding]; other site 1191061015673 putative RNA binding site [nucleotide binding]; other site 1191061015674 argininosuccinate synthase; Validated; Region: PRK05370 1191061015675 argininosuccinate synthase; Provisional; Region: PRK13820 1191061015676 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1191061015677 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 1191061015678 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1191061015679 active site 1191061015680 substrate binding site [chemical binding]; other site 1191061015681 metal binding site [ion binding]; metal-binding site 1191061015682 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1191061015683 dihydropteroate synthase; Region: DHPS; TIGR01496 1191061015684 substrate binding pocket [chemical binding]; other site 1191061015685 dimer interface [polypeptide binding]; other site 1191061015686 inhibitor binding site; inhibition site 1191061015687 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 1191061015688 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191061015689 Walker A motif; other site 1191061015690 ATP binding site [chemical binding]; other site 1191061015691 Walker B motif; other site 1191061015692 arginine finger; other site 1191061015693 Peptidase family M41; Region: Peptidase_M41; pfam01434 1191061015694 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1191061015695 FtsJ-like methyltransferase; Region: FtsJ; cl17430 1191061015696 RNA-binding protein YhbY; Provisional; Region: PRK10343 1191061015697 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1191061015698 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1191061015699 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1191061015700 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 1191061015701 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1191061015702 GTPase CgtA; Reviewed; Region: obgE; PRK12298 1191061015703 GTP1/OBG; Region: GTP1_OBG; pfam01018 1191061015704 Obg GTPase; Region: Obg; cd01898 1191061015705 G1 box; other site 1191061015706 GTP/Mg2+ binding site [chemical binding]; other site 1191061015707 Switch I region; other site 1191061015708 G2 box; other site 1191061015709 G3 box; other site 1191061015710 Switch II region; other site 1191061015711 G4 box; other site 1191061015712 G5 box; other site 1191061015713 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1191061015714 EamA-like transporter family; Region: EamA; pfam00892 1191061015715 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1191061015716 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1191061015717 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1191061015718 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1191061015719 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1191061015720 substrate binding pocket [chemical binding]; other site 1191061015721 chain length determination region; other site 1191061015722 substrate-Mg2+ binding site; other site 1191061015723 catalytic residues [active] 1191061015724 aspartate-rich region 1; other site 1191061015725 active site lid residues [active] 1191061015726 aspartate-rich region 2; other site 1191061015727 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 1191061015728 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1191061015729 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1191061015730 hinge; other site 1191061015731 active site 1191061015732 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 1191061015733 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1191061015734 anti sigma factor interaction site; other site 1191061015735 regulatory phosphorylation site [posttranslational modification]; other site 1191061015736 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 1191061015737 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1191061015738 mce related protein; Region: MCE; pfam02470 1191061015739 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1191061015740 conserved hypothetical integral membrane protein; Region: TIGR00056 1191061015741 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 1191061015742 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1191061015743 Walker A/P-loop; other site 1191061015744 ATP binding site [chemical binding]; other site 1191061015745 Q-loop/lid; other site 1191061015746 ABC transporter signature motif; other site 1191061015747 Walker B; other site 1191061015748 D-loop; other site 1191061015749 H-loop/switch region; other site 1191061015750 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 1191061015751 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1191061015752 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1191061015753 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1191061015754 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1191061015755 putative active site [active] 1191061015756 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1191061015757 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 1191061015758 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1191061015759 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 1191061015760 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1191061015761 OstA-like protein; Region: OstA; cl00844 1191061015762 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 1191061015763 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 1191061015764 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1191061015765 Walker A/P-loop; other site 1191061015766 ATP binding site [chemical binding]; other site 1191061015767 Q-loop/lid; other site 1191061015768 ABC transporter signature motif; other site 1191061015769 Walker B; other site 1191061015770 D-loop; other site 1191061015771 H-loop/switch region; other site 1191061015772 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1191061015773 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1191061015774 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1191061015775 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1191061015776 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1191061015777 30S subunit binding site; other site 1191061015778 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1191061015779 active site 1191061015780 phosphorylation site [posttranslational modification] 1191061015781 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 1191061015782 AAA domain; Region: AAA_18; pfam13238 1191061015783 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1191061015784 dimerization domain swap beta strand [polypeptide binding]; other site 1191061015785 regulatory protein interface [polypeptide binding]; other site 1191061015786 active site 1191061015787 regulatory phosphorylation site [posttranslational modification]; other site 1191061015788 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 1191061015789 Transglycosylase; Region: Transgly; cl17702 1191061015790 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 1191061015791 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 1191061015792 conserved cys residue [active] 1191061015793 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 1191061015794 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191061015795 putative active site [active] 1191061015796 heme pocket [chemical binding]; other site 1191061015797 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191061015798 dimer interface [polypeptide binding]; other site 1191061015799 phosphorylation site [posttranslational modification] 1191061015800 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191061015801 ATP binding site [chemical binding]; other site 1191061015802 Mg2+ binding site [ion binding]; other site 1191061015803 G-X-G motif; other site 1191061015804 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191061015805 active site 1191061015806 phosphorylation site [posttranslational modification] 1191061015807 intermolecular recognition site; other site 1191061015808 dimerization interface [polypeptide binding]; other site 1191061015809 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1191061015810 putative binding surface; other site 1191061015811 active site 1191061015812 radical SAM protein, TIGR01212 family; Region: TIGR01212 1191061015813 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1191061015814 FeS/SAM binding site; other site 1191061015815 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1191061015816 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1191061015817 active site 1191061015818 dimer interface [polypeptide binding]; other site 1191061015819 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1191061015820 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1191061015821 active site 1191061015822 FMN binding site [chemical binding]; other site 1191061015823 substrate binding site [chemical binding]; other site 1191061015824 3Fe-4S cluster binding site [ion binding]; other site 1191061015825 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1191061015826 domain interface; other site 1191061015827 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 1191061015828 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1191061015829 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1191061015830 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1191061015831 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 1191061015832 N-acetylmannosamine kinase; Provisional; Region: PRK05082 1191061015833 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1191061015834 nucleotide binding site [chemical binding]; other site 1191061015835 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 1191061015836 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1191061015837 putative active site cavity [active] 1191061015838 potential frameshift: common BLAST hit: gi|375257585|ref|YP_005016755.1| putative sialic acid transporter 1191061015839 putative sialic acid transporter; Provisional; Region: PRK03893 1191061015840 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061015841 putative substrate translocation pore; other site 1191061015842 N-acetylneuraminate lyase; Provisional; Region: PRK04147 1191061015843 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 1191061015844 inhibitor site; inhibition site 1191061015845 active site 1191061015846 dimer interface [polypeptide binding]; other site 1191061015847 catalytic residue [active] 1191061015848 transcriptional regulator NanR; Provisional; Region: PRK03837 1191061015849 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1191061015850 DNA-binding site [nucleotide binding]; DNA binding site 1191061015851 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1191061015852 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 1191061015853 stringent starvation protein A; Provisional; Region: sspA; PRK09481 1191061015854 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 1191061015855 C-terminal domain interface [polypeptide binding]; other site 1191061015856 putative GSH binding site (G-site) [chemical binding]; other site 1191061015857 dimer interface [polypeptide binding]; other site 1191061015858 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 1191061015859 dimer interface [polypeptide binding]; other site 1191061015860 N-terminal domain interface [polypeptide binding]; other site 1191061015861 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1191061015862 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1191061015863 23S rRNA interface [nucleotide binding]; other site 1191061015864 L3 interface [polypeptide binding]; other site 1191061015865 Predicted ATPase [General function prediction only]; Region: COG1485 1191061015866 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 1191061015867 hypothetical protein; Provisional; Region: PRK11677 1191061015868 serine endoprotease; Provisional; Region: PRK10139 1191061015869 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1191061015870 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1191061015871 protein binding site [polypeptide binding]; other site 1191061015872 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1191061015873 serine endoprotease; Provisional; Region: PRK10898 1191061015874 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1191061015875 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1191061015876 protein binding site [polypeptide binding]; other site 1191061015877 Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767 1191061015878 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 1191061015879 oxaloacetate decarboxylase; Provisional; Region: PRK14040 1191061015880 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1191061015881 active site 1191061015882 catalytic residues [active] 1191061015883 metal binding site [ion binding]; metal-binding site 1191061015884 homodimer binding site [polypeptide binding]; other site 1191061015885 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1191061015886 carboxyltransferase (CT) interaction site; other site 1191061015887 biotinylation site [posttranslational modification]; other site 1191061015888 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 1191061015889 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 1191061015890 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 1191061015891 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1191061015892 transmembrane helices; other site 1191061015893 Citrate transporter; Region: CitMHS; pfam03600 1191061015894 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1191061015895 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1191061015896 DNA-binding site [nucleotide binding]; DNA binding site 1191061015897 FCD domain; Region: FCD; pfam07729 1191061015898 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1191061015899 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1191061015900 DNA-binding site [nucleotide binding]; DNA binding site 1191061015901 malate dehydrogenase; Provisional; Region: PRK05086 1191061015902 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 1191061015903 NAD binding site [chemical binding]; other site 1191061015904 dimerization interface [polypeptide binding]; other site 1191061015905 Substrate binding site [chemical binding]; other site 1191061015906 arginine repressor; Provisional; Region: PRK05066 1191061015907 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1191061015908 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1191061015909 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1191061015910 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1191061015911 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 1191061015912 RNAase interaction site [polypeptide binding]; other site 1191061015913 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 1191061015914 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1191061015915 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 1191061015916 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1191061015917 HlyD family secretion protein; Region: HlyD_3; pfam13437 1191061015918 efflux system membrane protein; Provisional; Region: PRK11594 1191061015919 transcriptional regulator; Provisional; Region: PRK10632 1191061015920 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061015921 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1191061015922 putative effector binding pocket; other site 1191061015923 dimerization interface [polypeptide binding]; other site 1191061015924 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 1191061015925 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1191061015926 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1191061015927 protease TldD; Provisional; Region: tldD; PRK10735 1191061015928 hypothetical protein; Provisional; Region: PRK10899 1191061015929 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1191061015930 ribonuclease G; Provisional; Region: PRK11712 1191061015931 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1191061015932 homodimer interface [polypeptide binding]; other site 1191061015933 oligonucleotide binding site [chemical binding]; other site 1191061015934 Maf-like protein; Region: Maf; pfam02545 1191061015935 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1191061015936 active site 1191061015937 dimer interface [polypeptide binding]; other site 1191061015938 rod shape-determining protein MreD; Provisional; Region: PRK11060 1191061015939 rod shape-determining protein MreC; Region: mreC; TIGR00219 1191061015940 rod shape-determining protein MreC; Region: MreC; pfam04085 1191061015941 rod shape-determining protein MreB; Provisional; Region: PRK13927 1191061015942 MreB and similar proteins; Region: MreB_like; cd10225 1191061015943 nucleotide binding site [chemical binding]; other site 1191061015944 Mg binding site [ion binding]; other site 1191061015945 putative protofilament interaction site [polypeptide binding]; other site 1191061015946 RodZ interaction site [polypeptide binding]; other site 1191061015947 regulatory protein CsrD; Provisional; Region: PRK11059 1191061015948 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1191061015949 metal binding site [ion binding]; metal-binding site 1191061015950 active site 1191061015951 I-site; other site 1191061015952 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1191061015953 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1191061015954 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1191061015955 NADP binding site [chemical binding]; other site 1191061015956 dimer interface [polypeptide binding]; other site 1191061015957 TMAO/DMSO reductase; Reviewed; Region: PRK05363 1191061015958 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 1191061015959 Moco binding site; other site 1191061015960 metal coordination site [ion binding]; other site 1191061015961 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 1191061015962 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1191061015963 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1191061015964 carboxyltransferase (CT) interaction site; other site 1191061015965 biotinylation site [posttranslational modification]; other site 1191061015966 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1191061015967 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1191061015968 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1191061015969 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1191061015970 hypothetical protein; Provisional; Region: PRK10633 1191061015971 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 1191061015972 Na binding site [ion binding]; other site 1191061015973 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1191061015974 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1191061015975 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 1191061015976 active site 1191061015977 zinc binding site [ion binding]; other site 1191061015978 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 1191061015979 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1191061015980 FMN binding site [chemical binding]; other site 1191061015981 active site 1191061015982 catalytic residues [active] 1191061015983 substrate binding site [chemical binding]; other site 1191061015984 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 1191061015985 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 1191061015986 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 1191061015987 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1191061015988 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1191061015989 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1191061015990 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1191061015991 HlyD family secretion protein; Region: HlyD_3; pfam13437 1191061015992 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 1191061015993 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1191061015994 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1191061015995 trimer interface [polypeptide binding]; other site 1191061015996 putative metal binding site [ion binding]; other site 1191061015997 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 1191061015998 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1191061015999 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1191061016000 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1191061016001 shikimate binding site; other site 1191061016002 NAD(P) binding site [chemical binding]; other site 1191061016003 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 1191061016004 hypothetical protein; Validated; Region: PRK03430 1191061016005 hypothetical protein; Provisional; Region: PRK10736 1191061016006 DNA protecting protein DprA; Region: dprA; TIGR00732 1191061016007 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1191061016008 active site 1191061016009 catalytic residues [active] 1191061016010 metal binding site [ion binding]; metal-binding site 1191061016011 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1191061016012 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1191061016013 putative active site [active] 1191061016014 substrate binding site [chemical binding]; other site 1191061016015 putative cosubstrate binding site; other site 1191061016016 catalytic site [active] 1191061016017 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1191061016018 substrate binding site [chemical binding]; other site 1191061016019 16S rRNA methyltransferase B; Provisional; Region: PRK10901 1191061016020 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1191061016021 putative RNA binding site [nucleotide binding]; other site 1191061016022 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191061016023 S-adenosylmethionine binding site [chemical binding]; other site 1191061016024 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1191061016025 TrkA-N domain; Region: TrkA_N; pfam02254 1191061016026 TrkA-C domain; Region: TrkA_C; pfam02080 1191061016027 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1191061016028 TrkA-N domain; Region: TrkA_N; pfam02254 1191061016029 TrkA-C domain; Region: TrkA_C; pfam02080 1191061016030 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1191061016031 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1191061016032 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 1191061016033 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1191061016034 DNA binding residues [nucleotide binding] 1191061016035 dimer interface [polypeptide binding]; other site 1191061016036 metal binding site [ion binding]; metal-binding site 1191061016037 hypothetical protein; Provisional; Region: PRK10203 1191061016038 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1191061016039 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1191061016040 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1191061016041 alphaNTD homodimer interface [polypeptide binding]; other site 1191061016042 alphaNTD - beta interaction site [polypeptide binding]; other site 1191061016043 alphaNTD - beta' interaction site [polypeptide binding]; other site 1191061016044 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1191061016045 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1191061016046 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1191061016047 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1191061016048 RNA binding surface [nucleotide binding]; other site 1191061016049 30S ribosomal protein S11; Validated; Region: PRK05309 1191061016050 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1191061016051 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1191061016052 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 1191061016053 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1191061016054 SecY translocase; Region: SecY; pfam00344 1191061016055 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1191061016056 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1191061016057 23S rRNA binding site [nucleotide binding]; other site 1191061016058 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1191061016059 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1191061016060 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1191061016061 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1191061016062 23S rRNA interface [nucleotide binding]; other site 1191061016063 5S rRNA interface [nucleotide binding]; other site 1191061016064 L27 interface [polypeptide binding]; other site 1191061016065 L5 interface [polypeptide binding]; other site 1191061016066 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1191061016067 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1191061016068 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1191061016069 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1191061016070 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1191061016071 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1191061016072 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1191061016073 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1191061016074 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1191061016075 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1191061016076 RNA binding site [nucleotide binding]; other site 1191061016077 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1191061016078 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1191061016079 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1191061016080 23S rRNA interface [nucleotide binding]; other site 1191061016081 putative translocon interaction site; other site 1191061016082 signal recognition particle (SRP54) interaction site; other site 1191061016083 L23 interface [polypeptide binding]; other site 1191061016084 trigger factor interaction site; other site 1191061016085 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1191061016086 23S rRNA interface [nucleotide binding]; other site 1191061016087 5S rRNA interface [nucleotide binding]; other site 1191061016088 putative antibiotic binding site [chemical binding]; other site 1191061016089 L25 interface [polypeptide binding]; other site 1191061016090 L27 interface [polypeptide binding]; other site 1191061016091 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1191061016092 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1191061016093 G-X-X-G motif; other site 1191061016094 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1191061016095 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1191061016096 protein-rRNA interface [nucleotide binding]; other site 1191061016097 putative translocon binding site; other site 1191061016098 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 1191061016099 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1191061016100 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1191061016101 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1191061016102 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1191061016103 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1191061016104 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 1191061016105 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1191061016106 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1191061016107 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1191061016108 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1191061016109 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1191061016110 heme binding site [chemical binding]; other site 1191061016111 ferroxidase pore; other site 1191061016112 ferroxidase diiron center [ion binding]; other site 1191061016113 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 1191061016114 elongation factor Tu; Reviewed; Region: PRK00049 1191061016115 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1191061016116 G1 box; other site 1191061016117 GEF interaction site [polypeptide binding]; other site 1191061016118 GTP/Mg2+ binding site [chemical binding]; other site 1191061016119 Switch I region; other site 1191061016120 G2 box; other site 1191061016121 G3 box; other site 1191061016122 Switch II region; other site 1191061016123 G4 box; other site 1191061016124 G5 box; other site 1191061016125 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1191061016126 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1191061016127 Antibiotic Binding Site [chemical binding]; other site 1191061016128 elongation factor G; Reviewed; Region: PRK00007 1191061016129 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1191061016130 G1 box; other site 1191061016131 putative GEF interaction site [polypeptide binding]; other site 1191061016132 GTP/Mg2+ binding site [chemical binding]; other site 1191061016133 Switch I region; other site 1191061016134 G2 box; other site 1191061016135 G3 box; other site 1191061016136 Switch II region; other site 1191061016137 G4 box; other site 1191061016138 G5 box; other site 1191061016139 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1191061016140 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1191061016141 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1191061016142 30S ribosomal protein S7; Validated; Region: PRK05302 1191061016143 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1191061016144 S17 interaction site [polypeptide binding]; other site 1191061016145 S8 interaction site; other site 1191061016146 16S rRNA interaction site [nucleotide binding]; other site 1191061016147 streptomycin interaction site [chemical binding]; other site 1191061016148 23S rRNA interaction site [nucleotide binding]; other site 1191061016149 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1191061016150 DsrH like protein; Region: DsrH; cl17347 1191061016151 sulfur relay protein TusC; Validated; Region: PRK00211 1191061016152 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 1191061016153 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1191061016154 YheO-like PAS domain; Region: PAS_6; pfam08348 1191061016155 HTH domain; Region: HTH_22; pfam13309 1191061016156 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 1191061016157 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1191061016158 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1191061016159 phi X174 lysis protein; Provisional; Region: PRK02793 1191061016160 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10737 1191061016161 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1191061016162 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 1191061016163 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 1191061016164 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 1191061016165 TrkA-N domain; Region: TrkA_N; pfam02254 1191061016166 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 1191061016167 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 1191061016168 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1191061016169 Walker A/P-loop; other site 1191061016170 ATP binding site [chemical binding]; other site 1191061016171 Q-loop/lid; other site 1191061016172 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1191061016173 ABC transporter signature motif; other site 1191061016174 Walker B; other site 1191061016175 D-loop; other site 1191061016176 ABC transporter; Region: ABC_tran_2; pfam12848 1191061016177 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1191061016178 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 1191061016179 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 1191061016180 active site 1191061016181 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 1191061016182 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1191061016183 active site 1191061016184 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1191061016185 nudix motif; other site 1191061016186 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1191061016187 putative hydrolase; Provisional; Region: PRK10985 1191061016188 hypothetical protein; Provisional; Region: PRK04966 1191061016189 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 1191061016190 active site 1191061016191 hypothetical protein; Provisional; Region: PRK10738 1191061016192 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 1191061016193 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1191061016194 ligand binding site [chemical binding]; other site 1191061016195 flexible hinge region; other site 1191061016196 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1191061016197 putative switch regulator; other site 1191061016198 non-specific DNA interactions [nucleotide binding]; other site 1191061016199 DNA binding site [nucleotide binding] 1191061016200 sequence specific DNA binding site [nucleotide binding]; other site 1191061016201 putative cAMP binding site [chemical binding]; other site 1191061016202 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 1191061016203 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1191061016204 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1191061016205 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 1191061016206 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1191061016207 inhibitor-cofactor binding pocket; inhibition site 1191061016208 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061016209 catalytic residue [active] 1191061016210 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1191061016211 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1191061016212 glutamine binding [chemical binding]; other site 1191061016213 catalytic triad [active] 1191061016214 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 1191061016215 cell filamentation protein Fic; Provisional; Region: PRK10347 1191061016216 hypothetical protein; Provisional; Region: PRK10204 1191061016217 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 1191061016218 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1191061016219 substrate binding site [chemical binding]; other site 1191061016220 putative transporter; Provisional; Region: PRK03699 1191061016221 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061016222 putative substrate translocation pore; other site 1191061016223 nitrite reductase subunit NirD; Provisional; Region: PRK14989 1191061016224 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1191061016225 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1191061016226 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1191061016227 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1191061016228 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1191061016229 nitrite transporter NirC; Provisional; Region: PRK11562 1191061016230 siroheme synthase; Provisional; Region: cysG; PRK10637 1191061016231 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1191061016232 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1191061016233 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1191061016234 active site 1191061016235 SAM binding site [chemical binding]; other site 1191061016236 homodimer interface [polypeptide binding]; other site 1191061016237 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1191061016238 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1191061016239 active site 1191061016240 HIGH motif; other site 1191061016241 dimer interface [polypeptide binding]; other site 1191061016242 KMSKS motif; other site 1191061016243 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1191061016244 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1191061016245 motif II; other site 1191061016246 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1191061016247 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1191061016248 substrate binding site [chemical binding]; other site 1191061016249 hexamer interface [polypeptide binding]; other site 1191061016250 metal binding site [ion binding]; metal-binding site 1191061016251 DNA adenine methylase; Provisional; Region: PRK10904 1191061016252 cell division protein DamX; Validated; Region: PRK10905 1191061016253 cell division protein DamX; Validated; Region: PRK10905 1191061016254 potential frameshift: common BLAST hit: gi|375257727|ref|YP_005016897.1| 3-dehydroquinate synthase 1191061016255 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1191061016256 metal binding site [ion binding]; metal-binding site 1191061016257 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1191061016258 active site 1191061016259 NAD binding site [chemical binding]; other site 1191061016260 shikimate kinase; Reviewed; Region: aroK; PRK00131 1191061016261 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1191061016262 ADP binding site [chemical binding]; other site 1191061016263 magnesium binding site [ion binding]; other site 1191061016264 putative shikimate binding site; other site 1191061016265 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 1191061016266 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1191061016267 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1191061016268 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 1191061016269 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1191061016270 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 1191061016271 potential frameshift: common BLAST hit: gi|375257734|ref|YP_005016904.1| penicillin-binding protein 1a 1191061016272 Transglycosylase; Region: Transgly; pfam00912 1191061016273 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 1191061016274 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1191061016275 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 1191061016276 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1191061016277 ADP-ribose binding site [chemical binding]; other site 1191061016278 dimer interface [polypeptide binding]; other site 1191061016279 active site 1191061016280 nudix motif; other site 1191061016281 metal binding site [ion binding]; metal-binding site 1191061016282 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 1191061016283 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1191061016284 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1191061016285 motif II; other site 1191061016286 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1191061016287 RNA binding surface [nucleotide binding]; other site 1191061016288 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1191061016289 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1191061016290 dimerization interface [polypeptide binding]; other site 1191061016291 domain crossover interface; other site 1191061016292 redox-dependent activation switch; other site 1191061016293 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1191061016294 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1191061016295 active site 1191061016296 substrate-binding site [chemical binding]; other site 1191061016297 metal-binding site [ion binding] 1191061016298 ATP binding site [chemical binding]; other site 1191061016299 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1191061016300 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 1191061016301 maltodextrin phosphorylase; Provisional; Region: PRK14985 1191061016302 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1191061016303 homodimer interface [polypeptide binding]; other site 1191061016304 active site pocket [active] 1191061016305 transcriptional regulator MalT; Provisional; Region: PRK04841 1191061016306 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1191061016307 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1191061016308 DNA binding residues [nucleotide binding] 1191061016309 dimerization interface [polypeptide binding]; other site 1191061016310 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 1191061016311 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1191061016312 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1191061016313 intramembrane serine protease GlpG; Provisional; Region: PRK10907 1191061016314 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 1191061016315 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1191061016316 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 1191061016317 active site residue [active] 1191061016318 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 1191061016319 glycogen phosphorylase; Provisional; Region: PRK14986 1191061016320 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1191061016321 homodimer interface [polypeptide binding]; other site 1191061016322 active site pocket [active] 1191061016323 glycogen synthase; Provisional; Region: glgA; PRK00654 1191061016324 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1191061016325 ADP-binding pocket [chemical binding]; other site 1191061016326 homodimer interface [polypeptide binding]; other site 1191061016327 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 1191061016328 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1191061016329 ligand binding site; other site 1191061016330 oligomer interface; other site 1191061016331 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1191061016332 dimer interface [polypeptide binding]; other site 1191061016333 N-terminal domain interface [polypeptide binding]; other site 1191061016334 sulfate 1 binding site; other site 1191061016335 glycogen debranching enzyme; Provisional; Region: PRK03705 1191061016336 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1191061016337 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1191061016338 active site 1191061016339 catalytic site [active] 1191061016340 glycogen branching enzyme; Provisional; Region: PRK05402 1191061016341 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1191061016342 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1191061016343 active site 1191061016344 catalytic site [active] 1191061016345 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1191061016346 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 1191061016347 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1191061016348 low affinity gluconate transporter; Provisional; Region: PRK10472 1191061016349 gluconate transporter; Region: gntP; TIGR00791 1191061016350 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1191061016351 ATP-binding site [chemical binding]; other site 1191061016352 Gluconate-6-phosphate binding site [chemical binding]; other site 1191061016353 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 1191061016354 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1191061016355 DNA binding site [nucleotide binding] 1191061016356 domain linker motif; other site 1191061016357 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1191061016358 putative ligand binding site [chemical binding]; other site 1191061016359 putative dimerization interface [polypeptide binding]; other site 1191061016360 Pirin-related protein [General function prediction only]; Region: COG1741 1191061016361 Pirin; Region: Pirin; pfam02678 1191061016362 putative oxidoreductase; Provisional; Region: PRK10206 1191061016363 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1191061016364 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1191061016365 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1191061016366 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1191061016367 putative acetyltransferase YhhY; Provisional; Region: PRK10140 1191061016368 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1191061016369 Coenzyme A binding pocket [chemical binding]; other site 1191061016370 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 1191061016371 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1191061016372 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 1191061016373 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 1191061016374 putative active site [active] 1191061016375 catalytic site [active] 1191061016376 putative metal binding site [ion binding]; other site 1191061016377 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1191061016378 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1191061016379 Walker A/P-loop; other site 1191061016380 ATP binding site [chemical binding]; other site 1191061016381 Q-loop/lid; other site 1191061016382 ABC transporter signature motif; other site 1191061016383 Walker B; other site 1191061016384 D-loop; other site 1191061016385 H-loop/switch region; other site 1191061016386 TOBE domain; Region: TOBE_2; pfam08402 1191061016387 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1191061016388 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061016389 dimer interface [polypeptide binding]; other site 1191061016390 conserved gate region; other site 1191061016391 ABC-ATPase subunit interface; other site 1191061016392 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1191061016393 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061016394 dimer interface [polypeptide binding]; other site 1191061016395 conserved gate region; other site 1191061016396 putative PBP binding loops; other site 1191061016397 ABC-ATPase subunit interface; other site 1191061016398 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 1191061016399 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1191061016400 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1191061016401 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1191061016402 Bacterial transcriptional regulator; Region: IclR; pfam01614 1191061016403 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1191061016404 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1191061016405 inhibitor site; inhibition site 1191061016406 active site 1191061016407 dimer interface [polypeptide binding]; other site 1191061016408 catalytic residue [active] 1191061016409 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1191061016410 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061016411 putative substrate translocation pore; other site 1191061016412 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1191061016413 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1191061016414 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1191061016415 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 1191061016416 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1191061016417 Walker A/P-loop; other site 1191061016418 ATP binding site [chemical binding]; other site 1191061016419 Q-loop/lid; other site 1191061016420 ABC transporter signature motif; other site 1191061016421 Walker B; other site 1191061016422 D-loop; other site 1191061016423 H-loop/switch region; other site 1191061016424 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1191061016425 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1191061016426 Walker A/P-loop; other site 1191061016427 ATP binding site [chemical binding]; other site 1191061016428 Q-loop/lid; other site 1191061016429 ABC transporter signature motif; other site 1191061016430 Walker B; other site 1191061016431 D-loop; other site 1191061016432 H-loop/switch region; other site 1191061016433 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1191061016434 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1191061016435 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1191061016436 TM-ABC transporter signature motif; other site 1191061016437 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1191061016438 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1191061016439 TM-ABC transporter signature motif; other site 1191061016440 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1191061016441 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1191061016442 dimerization interface [polypeptide binding]; other site 1191061016443 ligand binding site [chemical binding]; other site 1191061016444 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 1191061016445 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1191061016446 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1191061016447 dimerization interface [polypeptide binding]; other site 1191061016448 ligand binding site [chemical binding]; other site 1191061016449 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1191061016450 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1191061016451 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1191061016452 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1191061016453 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1191061016454 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 1191061016455 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1191061016456 inhibitor-cofactor binding pocket; inhibition site 1191061016457 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061016458 catalytic residue [active] 1191061016459 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1191061016460 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1191061016461 DNA-binding site [nucleotide binding]; DNA binding site 1191061016462 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1191061016463 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061016464 homodimer interface [polypeptide binding]; other site 1191061016465 catalytic residue [active] 1191061016466 alternative sigma factor RpoH; Region: rpoH_proteo; TIGR02392 1191061016467 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1191061016468 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1191061016469 DNA binding residues [nucleotide binding] 1191061016470 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1191061016471 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 1191061016472 cell division protein FtsE; Provisional; Region: PRK10908 1191061016473 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1191061016474 Walker A/P-loop; other site 1191061016475 ATP binding site [chemical binding]; other site 1191061016476 Q-loop/lid; other site 1191061016477 ABC transporter signature motif; other site 1191061016478 Walker B; other site 1191061016479 D-loop; other site 1191061016480 H-loop/switch region; other site 1191061016481 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1191061016482 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1191061016483 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1191061016484 P loop; other site 1191061016485 GTP binding site [chemical binding]; other site 1191061016486 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1191061016487 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191061016488 S-adenosylmethionine binding site [chemical binding]; other site 1191061016489 hypothetical protein; Provisional; Region: PRK10910 1191061016490 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 1191061016491 Predicted membrane protein [Function unknown]; Region: COG3714 1191061016492 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 1191061016493 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1191061016494 metal-binding site [ion binding] 1191061016495 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1191061016496 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 1191061016497 CPxP motif; other site 1191061016498 hypothetical protein; Provisional; Region: PRK11212 1191061016499 hypothetical protein; Provisional; Region: PRK11615 1191061016500 major facilitator superfamily transporter; Provisional; Region: PRK05122 1191061016501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061016502 putative substrate translocation pore; other site 1191061016503 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1191061016504 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1191061016505 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1191061016506 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191061016507 S-adenosylmethionine binding site [chemical binding]; other site 1191061016508 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 1191061016509 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 1191061016510 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1191061016511 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1191061016512 putative acyl-acceptor binding pocket; other site 1191061016513 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1191061016514 acyl carrier protein; Provisional; Region: PRK05350 1191061016515 Predicted membrane protein [Function unknown]; Region: COG4648 1191061016516 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1191061016517 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1191061016518 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1191061016519 acyl-activating enzyme (AAE) consensus motif; other site 1191061016520 acyl-activating enzyme (AAE) consensus motif; other site 1191061016521 AMP binding site [chemical binding]; other site 1191061016522 active site 1191061016523 CoA binding site [chemical binding]; other site 1191061016524 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1191061016525 active site 2 [active] 1191061016526 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1191061016527 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1191061016528 Ligand binding site; other site 1191061016529 Putative Catalytic site; other site 1191061016530 DXD motif; other site 1191061016531 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1191061016532 putative acyl-acceptor binding pocket; other site 1191061016533 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1191061016534 active site 1191061016535 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 1191061016536 Predicted exporter [General function prediction only]; Region: COG4258 1191061016537 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 1191061016538 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 1191061016539 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1191061016540 dimer interface [polypeptide binding]; other site 1191061016541 active site 1191061016542 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 1191061016543 putative active site 1 [active] 1191061016544 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1191061016545 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 1191061016546 NAD(P) binding site [chemical binding]; other site 1191061016547 active site 1191061016548 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 1191061016549 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1191061016550 dimer interface [polypeptide binding]; other site 1191061016551 active site 1191061016552 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 1191061016553 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1191061016554 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 1191061016555 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 1191061016556 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 1191061016557 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1191061016558 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 1191061016559 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1191061016560 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 1191061016561 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1191061016562 active site 1191061016563 substrate binding site [chemical binding]; other site 1191061016564 cosubstrate binding site; other site 1191061016565 catalytic site [active] 1191061016566 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 1191061016567 active site 1191061016568 hexamer interface [polypeptide binding]; other site 1191061016569 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 1191061016570 NAD binding site [chemical binding]; other site 1191061016571 substrate binding site [chemical binding]; other site 1191061016572 active site 1191061016573 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1191061016574 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1191061016575 Putative Catalytic site; other site 1191061016576 DXD motif; other site 1191061016577 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1191061016578 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1191061016579 inhibitor-cofactor binding pocket; inhibition site 1191061016580 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061016581 catalytic residue [active] 1191061016582 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; pfam05870 1191061016583 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061016584 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061016585 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1191061016586 dimerization interface [polypeptide binding]; other site 1191061016587 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 1191061016588 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1191061016589 substrate binding site [chemical binding]; other site 1191061016590 nickel transporter permease NikB; Provisional; Region: PRK10352 1191061016591 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061016592 dimer interface [polypeptide binding]; other site 1191061016593 conserved gate region; other site 1191061016594 putative PBP binding loops; other site 1191061016595 ABC-ATPase subunit interface; other site 1191061016596 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 1191061016597 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061016598 dimer interface [polypeptide binding]; other site 1191061016599 conserved gate region; other site 1191061016600 putative PBP binding loops; other site 1191061016601 ABC-ATPase subunit interface; other site 1191061016602 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 1191061016603 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1191061016604 Walker A/P-loop; other site 1191061016605 ATP binding site [chemical binding]; other site 1191061016606 Q-loop/lid; other site 1191061016607 ABC transporter signature motif; other site 1191061016608 Walker B; other site 1191061016609 D-loop; other site 1191061016610 H-loop/switch region; other site 1191061016611 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 1191061016612 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1191061016613 Walker A/P-loop; other site 1191061016614 ATP binding site [chemical binding]; other site 1191061016615 Q-loop/lid; other site 1191061016616 ABC transporter signature motif; other site 1191061016617 Walker B; other site 1191061016618 D-loop; other site 1191061016619 H-loop/switch region; other site 1191061016620 nickel responsive regulator; Provisional; Region: PRK02967 1191061016621 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 1191061016622 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 1191061016623 FOG: CBS domain [General function prediction only]; Region: COG0517 1191061016624 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1191061016625 Divalent cation transporter; Region: MgtE; pfam01769 1191061016626 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1191061016627 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1191061016628 ligand binding site [chemical binding]; other site 1191061016629 NAD binding site [chemical binding]; other site 1191061016630 dimerization interface [polypeptide binding]; other site 1191061016631 catalytic site [active] 1191061016632 hypothetical protein; Validated; Region: PRK06201 1191061016633 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 1191061016634 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1191061016635 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1191061016636 putative metallo-dependent hydrolase; Provisional; Region: PRK12394 1191061016637 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1191061016638 active site 1191061016639 Propionate catabolism activator; Region: PrpR_N; pfam06506 1191061016640 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 1191061016641 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191061016642 Walker A motif; other site 1191061016643 ATP binding site [chemical binding]; other site 1191061016644 Walker B motif; other site 1191061016645 arginine finger; other site 1191061016646 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1191061016647 Predicted flavoproteins [General function prediction only]; Region: COG2081 1191061016648 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1191061016649 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1191061016650 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1191061016651 universal stress protein UspB; Provisional; Region: PRK04960 1191061016652 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1191061016653 Ligand Binding Site [chemical binding]; other site 1191061016654 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 1191061016655 POT family; Region: PTR2; cl17359 1191061016656 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191061016657 S-adenosylmethionine binding site [chemical binding]; other site 1191061016658 oligopeptidase A; Provisional; Region: PRK10911 1191061016659 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1191061016660 active site 1191061016661 Zn binding site [ion binding]; other site 1191061016662 high-affinity gluconate transporter; Provisional; Region: PRK14984 1191061016663 gluconate transporter; Region: gntP; TIGR00791 1191061016664 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 1191061016665 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1191061016666 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1191061016667 DNA utilization protein GntX; Provisional; Region: PRK11595 1191061016668 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1191061016669 active site 1191061016670 carboxylesterase BioH; Provisional; Region: PRK10349 1191061016671 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1191061016672 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1191061016673 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 1191061016674 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 1191061016675 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1191061016676 G1 box; other site 1191061016677 GTP/Mg2+ binding site [chemical binding]; other site 1191061016678 Switch I region; other site 1191061016679 G2 box; other site 1191061016680 G3 box; other site 1191061016681 Switch II region; other site 1191061016682 G4 box; other site 1191061016683 G5 box; other site 1191061016684 Nucleoside recognition; Region: Gate; pfam07670 1191061016685 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1191061016686 Nucleoside recognition; Region: Gate; pfam07670 1191061016687 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 1191061016688 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1191061016689 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1191061016690 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1191061016691 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1191061016692 RNA binding site [nucleotide binding]; other site 1191061016693 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 1191061016694 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1191061016695 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1191061016696 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1191061016697 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191061016698 active site 1191061016699 phosphorylation site [posttranslational modification] 1191061016700 intermolecular recognition site; other site 1191061016701 dimerization interface [polypeptide binding]; other site 1191061016702 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1191061016703 DNA binding site [nucleotide binding] 1191061016704 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 1191061016705 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1191061016706 dimerization interface [polypeptide binding]; other site 1191061016707 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1191061016708 dimer interface [polypeptide binding]; other site 1191061016709 phosphorylation site [posttranslational modification] 1191061016710 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191061016711 ATP binding site [chemical binding]; other site 1191061016712 Mg2+ binding site [ion binding]; other site 1191061016713 G-X-G motif; other site 1191061016714 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 1191061016715 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1191061016716 active site 1191061016717 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 1191061016718 glutathione reductase; Validated; Region: PRK06116 1191061016719 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1191061016720 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1191061016721 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1191061016722 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1191061016723 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 1191061016724 putative C-terminal domain interface [polypeptide binding]; other site 1191061016725 putative GSH binding site (G-site) [chemical binding]; other site 1191061016726 putative dimer interface [polypeptide binding]; other site 1191061016727 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 1191061016728 putative N-terminal domain interface [polypeptide binding]; other site 1191061016729 putative dimer interface [polypeptide binding]; other site 1191061016730 putative substrate binding pocket (H-site) [chemical binding]; other site 1191061016731 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183 1191061016732 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 1191061016733 putative active site [active] 1191061016734 metal binding site [ion binding]; metal-binding site 1191061016735 trehalase; Provisional; Region: treF; PRK13270 1191061016736 Trehalase; Region: Trehalase; pfam01204 1191061016737 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1191061016738 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1191061016739 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1191061016740 catalytic residue [active] 1191061016741 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1191061016742 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1191061016743 DNA binding residues [nucleotide binding] 1191061016744 dimerization interface [polypeptide binding]; other site 1191061016745 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1191061016746 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1191061016747 NAD(P) binding site [chemical binding]; other site 1191061016748 active site 1191061016749 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061016750 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061016751 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1191061016752 putative effector binding pocket; other site 1191061016753 putative dimerization interface [polypeptide binding]; other site 1191061016754 inner membrane protein YhjD; Region: TIGR00766 1191061016755 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061016756 metabolite-proton symporter; Region: 2A0106; TIGR00883 1191061016757 putative substrate translocation pore; other site 1191061016758 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 1191061016759 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1191061016760 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1191061016761 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1191061016762 substrate binding site [chemical binding]; other site 1191061016763 ATP binding site [chemical binding]; other site 1191061016764 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1191061016765 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1191061016766 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1191061016767 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1191061016768 putative diguanylate cyclase; Provisional; Region: PRK13561 1191061016769 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1191061016770 metal binding site [ion binding]; metal-binding site 1191061016771 active site 1191061016772 I-site; other site 1191061016773 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1191061016774 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 1191061016775 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191061016776 TPR motif; other site 1191061016777 binding surface 1191061016778 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191061016779 TPR motif; other site 1191061016780 binding surface 1191061016781 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 1191061016782 endo-1,4-D-glucanase; Provisional; Region: PRK11097 1191061016783 cellulose synthase regulator protein; Provisional; Region: PRK11114 1191061016784 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1191061016785 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 1191061016786 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1191061016787 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1191061016788 DXD motif; other site 1191061016789 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1191061016790 PilZ domain; Region: PilZ; pfam07238 1191061016791 cell division protein; Provisional; Region: PRK10037 1191061016792 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1191061016793 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 1191061016794 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 1191061016795 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 1191061016796 Protein of unknown function (DUF2636); Region: DUF2636; pfam11120 1191061016797 potential frameshift: common BLAST hit: gi|336247686|ref|YP_004591396.1| cellulose biosynthesis protein BcsG 1191061016798 Protein of unknown function (DUF3260); Region: DUF3260; cl11881 1191061016799 Protein of unknown function (DUF3260); Region: DUF3260; cl11881 1191061016800 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 1191061016801 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 1191061016802 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; pfam01270 1191061016803 Cellulose synthase subunit D; Region: Cellsynth_D; pfam03500 1191061016804 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 1191061016805 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1191061016806 binding surface 1191061016807 TPR motif; other site 1191061016808 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 1191061016809 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 1191061016810 cellulose synthase regulator protein; Provisional; Region: PRK11114 1191061016811 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 1191061016812 Cellulose synthase-like protein; Region: PLN02893 1191061016813 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1191061016814 DXD motif; other site 1191061016815 PilZ domain; Region: PilZ; pfam07238 1191061016816 cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371 1191061016817 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1191061016818 P-loop; other site 1191061016819 Magnesium ion binding site [ion binding]; other site 1191061016820 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1191061016821 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1191061016822 Walker A/P-loop; other site 1191061016823 ATP binding site [chemical binding]; other site 1191061016824 Q-loop/lid; other site 1191061016825 ABC transporter signature motif; other site 1191061016826 Walker B; other site 1191061016827 D-loop; other site 1191061016828 H-loop/switch region; other site 1191061016829 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1191061016830 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 1191061016831 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1191061016832 Walker A/P-loop; other site 1191061016833 ATP binding site [chemical binding]; other site 1191061016834 Q-loop/lid; other site 1191061016835 ABC transporter signature motif; other site 1191061016836 Walker B; other site 1191061016837 D-loop; other site 1191061016838 H-loop/switch region; other site 1191061016839 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1191061016840 dipeptide transporter; Provisional; Region: PRK10913 1191061016841 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1191061016842 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061016843 putative PBP binding loops; other site 1191061016844 dimer interface [polypeptide binding]; other site 1191061016845 ABC-ATPase subunit interface; other site 1191061016846 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1191061016847 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061016848 dimer interface [polypeptide binding]; other site 1191061016849 conserved gate region; other site 1191061016850 putative PBP binding loops; other site 1191061016851 ABC-ATPase subunit interface; other site 1191061016852 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1191061016853 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1191061016854 peptide binding site [polypeptide binding]; other site 1191061016855 phosphoethanolamine transferase; Provisional; Region: PRK11560 1191061016856 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1191061016857 Sulfatase; Region: Sulfatase; pfam00884 1191061016858 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1191061016859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061016860 putative substrate translocation pore; other site 1191061016861 Autotransporter beta-domain; Region: Autotransporter; cl17461 1191061016862 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 1191061016863 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1191061016864 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1191061016865 Coenzyme A binding pocket [chemical binding]; other site 1191061016866 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1191061016867 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1191061016868 molybdopterin cofactor binding site [chemical binding]; other site 1191061016869 substrate binding site [chemical binding]; other site 1191061016870 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1191061016871 molybdopterin cofactor binding site; other site 1191061016872 putative outer membrane lipoprotein; Provisional; Region: PRK10510 1191061016873 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1191061016874 ligand binding site [chemical binding]; other site 1191061016875 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1191061016876 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1191061016877 DNA binding site [nucleotide binding] 1191061016878 domain linker motif; other site 1191061016879 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 1191061016880 putative dimerization interface [polypeptide binding]; other site 1191061016881 putative ligand binding site [chemical binding]; other site 1191061016882 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1191061016883 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1191061016884 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1191061016885 substrate binding site [chemical binding]; other site 1191061016886 ATP binding site [chemical binding]; other site 1191061016887 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061016888 D-galactonate transporter; Region: 2A0114; TIGR00893 1191061016889 putative substrate translocation pore; other site 1191061016890 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1191061016891 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1191061016892 dimerization interface [polypeptide binding]; other site 1191061016893 ligand binding site [chemical binding]; other site 1191061016894 NADP binding site [chemical binding]; other site 1191061016895 catalytic site [active] 1191061016896 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 1191061016897 benzoate transport; Region: 2A0115; TIGR00895 1191061016898 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061016899 putative substrate translocation pore; other site 1191061016900 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061016901 Predicted transcriptional regulator [Transcription]; Region: COG2944 1191061016902 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1191061016903 salt bridge; other site 1191061016904 non-specific DNA binding site [nucleotide binding]; other site 1191061016905 sequence-specific DNA binding site [nucleotide binding]; other site 1191061016906 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1191061016907 DNA-binding site [nucleotide binding]; DNA binding site 1191061016908 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1191061016909 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1191061016910 Walker A/P-loop; other site 1191061016911 ATP binding site [chemical binding]; other site 1191061016912 Q-loop/lid; other site 1191061016913 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1191061016914 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1191061016915 Hok/gef family; Region: HOK_GEF; cl11494 1191061016916 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1191061016917 DALR anticodon binding domain; Region: DALR_1; pfam05746 1191061016918 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1191061016919 dimer interface [polypeptide binding]; other site 1191061016920 motif 1; other site 1191061016921 active site 1191061016922 motif 2; other site 1191061016923 motif 3; other site 1191061016924 YsaB-like lipoprotein; Region: YsaB; pfam13983 1191061016925 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1191061016926 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1191061016927 hypothetical protein; Provisional; Region: PRK11403 1191061016928 yiaA/B two helix domain; Region: YiaAB; pfam05360 1191061016929 xylulokinase; Provisional; Region: PRK15027 1191061016930 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1191061016931 N- and C-terminal domain interface [polypeptide binding]; other site 1191061016932 active site 1191061016933 MgATP binding site [chemical binding]; other site 1191061016934 catalytic site [active] 1191061016935 metal binding site [ion binding]; metal-binding site 1191061016936 xylulose binding site [chemical binding]; other site 1191061016937 homodimer interface [polypeptide binding]; other site 1191061016938 xylose isomerase; Provisional; Region: PRK05474 1191061016939 xylose isomerase; Region: xylose_isom_A; TIGR02630 1191061016940 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 1191061016941 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1191061016942 putative ligand binding site [chemical binding]; other site 1191061016943 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 1191061016944 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1191061016945 Walker A/P-loop; other site 1191061016946 ATP binding site [chemical binding]; other site 1191061016947 Q-loop/lid; other site 1191061016948 ABC transporter signature motif; other site 1191061016949 Walker B; other site 1191061016950 D-loop; other site 1191061016951 H-loop/switch region; other site 1191061016952 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1191061016953 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1191061016954 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1191061016955 TM-ABC transporter signature motif; other site 1191061016956 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 1191061016957 putative dimerization interface [polypeptide binding]; other site 1191061016958 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1191061016959 putative ligand binding site [chemical binding]; other site 1191061016960 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061016961 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1191061016962 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061016963 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 1191061016964 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 1191061016965 alpha-amylase; Reviewed; Region: malS; PRK09505 1191061016966 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1191061016967 active site 1191061016968 catalytic site [active] 1191061016969 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 1191061016970 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1191061016971 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061016972 homodimer interface [polypeptide binding]; other site 1191061016973 catalytic residue [active] 1191061016974 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 1191061016975 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1191061016976 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1191061016977 Bacterial transcriptional regulator; Region: IclR; pfam01614 1191061016978 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 1191061016979 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 1191061016980 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061016981 D-galactonate transporter; Region: 2A0114; TIGR00893 1191061016982 putative substrate translocation pore; other site 1191061016983 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1191061016984 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 1191061016985 putative N- and C-terminal domain interface [polypeptide binding]; other site 1191061016986 putative active site [active] 1191061016987 MgATP binding site [chemical binding]; other site 1191061016988 catalytic site [active] 1191061016989 metal binding site [ion binding]; metal-binding site 1191061016990 putative xylulose binding site [chemical binding]; other site 1191061016991 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1191061016992 active site 1191061016993 dimer interface [polypeptide binding]; other site 1191061016994 magnesium binding site [ion binding]; other site 1191061016995 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 1191061016996 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1191061016997 AP (apurinic/apyrimidinic) site pocket; other site 1191061016998 DNA interaction; other site 1191061016999 Metal-binding active site; metal-binding site 1191061017000 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1191061017001 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1191061017002 intersubunit interface [polypeptide binding]; other site 1191061017003 active site 1191061017004 Zn2+ binding site [ion binding]; other site 1191061017005 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1191061017006 Helix-turn-helix domain; Region: HTH_18; pfam12833 1191061017007 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061017008 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1191061017009 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1191061017010 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 1191061017011 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 1191061017012 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 1191061017013 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 1191061017014 G1 box; other site 1191061017015 putative GEF interaction site [polypeptide binding]; other site 1191061017016 GTP/Mg2+ binding site [chemical binding]; other site 1191061017017 Switch I region; other site 1191061017018 G2 box; other site 1191061017019 G3 box; other site 1191061017020 Switch II region; other site 1191061017021 G4 box; other site 1191061017022 G5 box; other site 1191061017023 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 1191061017024 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 1191061017025 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 1191061017026 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 1191061017027 selenocysteine synthase; Provisional; Region: PRK04311 1191061017028 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 1191061017029 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 1191061017030 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1191061017031 catalytic residue [active] 1191061017032 putative glutathione S-transferase; Provisional; Region: PRK10357 1191061017033 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 1191061017034 putative C-terminal domain interface [polypeptide binding]; other site 1191061017035 putative GSH binding site (G-site) [chemical binding]; other site 1191061017036 putative dimer interface [polypeptide binding]; other site 1191061017037 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1191061017038 dimer interface [polypeptide binding]; other site 1191061017039 N-terminal domain interface [polypeptide binding]; other site 1191061017040 putative substrate binding pocket (H-site) [chemical binding]; other site 1191061017041 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1191061017042 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1191061017043 HlyD family secretion protein; Region: HlyD_3; pfam13437 1191061017044 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 1191061017045 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 1191061017046 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1191061017047 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1191061017048 active site 1191061017049 P-loop; other site 1191061017050 phosphorylation site [posttranslational modification] 1191061017051 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1191061017052 active site 1191061017053 phosphorylation site [posttranslational modification] 1191061017054 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1191061017055 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1191061017056 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1191061017057 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 1191061017058 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 1191061017059 hypothetical protein; Provisional; Region: PRK11020 1191061017060 glycolate transporter; Provisional; Region: PRK09695 1191061017061 L-lactate permease; Provisional; Region: PRK10420 1191061017062 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 1191061017063 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1191061017064 DNA-binding site [nucleotide binding]; DNA binding site 1191061017065 FCD domain; Region: FCD; pfam07729 1191061017066 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 1191061017067 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1191061017068 active site 1191061017069 substrate binding site [chemical binding]; other site 1191061017070 FMN binding site [chemical binding]; other site 1191061017071 putative catalytic residues [active] 1191061017072 putative rRNA methylase; Provisional; Region: PRK10358 1191061017073 serine acetyltransferase; Provisional; Region: cysE; PRK11132 1191061017074 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 1191061017075 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1191061017076 trimer interface [polypeptide binding]; other site 1191061017077 active site 1191061017078 substrate binding site [chemical binding]; other site 1191061017079 CoA binding site [chemical binding]; other site 1191061017080 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1191061017081 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1191061017082 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1191061017083 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 1191061017084 SecA binding site; other site 1191061017085 Preprotein binding site; other site 1191061017086 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1191061017087 GSH binding site [chemical binding]; other site 1191061017088 catalytic residues [active] 1191061017089 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1191061017090 active site residue [active] 1191061017091 phosphoglyceromutase; Provisional; Region: PRK05434 1191061017092 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 1191061017093 AmiB activator; Provisional; Region: PRK11637 1191061017094 Peptidase family M23; Region: Peptidase_M23; pfam01551 1191061017095 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1191061017096 NodB motif; other site 1191061017097 putative active site [active] 1191061017098 putative catalytic site [active] 1191061017099 Zn binding site [ion binding]; other site 1191061017100 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1191061017101 putative metal binding site; other site 1191061017102 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1191061017103 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1191061017104 NAD(P) binding site [chemical binding]; other site 1191061017105 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1191061017106 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1191061017107 substrate-cofactor binding pocket; other site 1191061017108 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1191061017109 catalytic residue [active] 1191061017110 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 1191061017111 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 1191061017112 NADP binding site [chemical binding]; other site 1191061017113 homopentamer interface [polypeptide binding]; other site 1191061017114 substrate binding site [chemical binding]; other site 1191061017115 active site 1191061017116 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1191061017117 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1191061017118 putative active site [active] 1191061017119 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1191061017120 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1191061017121 putative active site [active] 1191061017122 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 1191061017123 O-Antigen ligase; Region: Wzy_C; pfam04932 1191061017124 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1191061017125 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1191061017126 Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935 1191061017127 putative active site [active] 1191061017128 putative catalytic site [active] 1191061017129 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 1191061017130 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1191061017131 putative active site [active] 1191061017132 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1191061017133 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 1191061017134 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1191061017135 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1191061017136 putative ADP-binding pocket [chemical binding]; other site 1191061017137 putative glycosyl transferase; Provisional; Region: PRK10073 1191061017138 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1191061017139 active site 1191061017140 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1191061017141 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1191061017142 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1191061017143 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1191061017144 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1191061017145 putative metal binding site; other site 1191061017146 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1191061017147 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1191061017148 active site 1191061017149 (T/H)XGH motif; other site 1191061017150 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1191061017151 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1191061017152 DNA binding site [nucleotide binding] 1191061017153 catalytic residue [active] 1191061017154 H2TH interface [polypeptide binding]; other site 1191061017155 putative catalytic residues [active] 1191061017156 turnover-facilitating residue; other site 1191061017157 intercalation triad [nucleotide binding]; other site 1191061017158 8OG recognition residue [nucleotide binding]; other site 1191061017159 putative reading head residues; other site 1191061017160 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1191061017161 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1191061017162 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1191061017163 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1191061017164 hypothetical protein; Reviewed; Region: PRK00024 1191061017165 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1191061017166 MPN+ (JAMM) motif; other site 1191061017167 Zinc-binding site [ion binding]; other site 1191061017168 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1191061017169 Flavoprotein; Region: Flavoprotein; pfam02441 1191061017170 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1191061017171 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1191061017172 trimer interface [polypeptide binding]; other site 1191061017173 active site 1191061017174 division inhibitor protein; Provisional; Region: slmA; PRK09480 1191061017175 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1191061017176 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1191061017177 active site 1191061017178 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1191061017179 ribonuclease PH; Reviewed; Region: rph; PRK00173 1191061017180 hexamer interface [polypeptide binding]; other site 1191061017181 active site 1191061017182 hypothetical protein; Provisional; Region: PRK11820 1191061017183 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1191061017184 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1191061017185 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 1191061017186 putative ion selectivity filter; other site 1191061017187 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1191061017188 putative pore gating glutamate residue; other site 1191061017189 Predicted membrane protein [Function unknown]; Region: COG2860 1191061017190 UPF0126 domain; Region: UPF0126; pfam03458 1191061017191 UPF0126 domain; Region: UPF0126; pfam03458 1191061017192 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 1191061017193 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 1191061017194 nucleotide binding pocket [chemical binding]; other site 1191061017195 K-X-D-G motif; other site 1191061017196 catalytic site [active] 1191061017197 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1191061017198 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1191061017199 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1191061017200 catalytic site [active] 1191061017201 G-X2-G-X-G-K; other site 1191061017202 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1191061017203 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 1191061017204 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1191061017205 Zn2+ binding site [ion binding]; other site 1191061017206 Mg2+ binding site [ion binding]; other site 1191061017207 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1191061017208 synthetase active site [active] 1191061017209 NTP binding site [chemical binding]; other site 1191061017210 metal binding site [ion binding]; metal-binding site 1191061017211 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1191061017212 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1191061017213 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 1191061017214 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1191061017215 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 1191061017216 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1191061017217 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1191061017218 generic binding surface II; other site 1191061017219 ssDNA binding site; other site 1191061017220 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1191061017221 ATP binding site [chemical binding]; other site 1191061017222 putative Mg++ binding site [ion binding]; other site 1191061017223 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1191061017224 nucleotide binding region [chemical binding]; other site 1191061017225 ATP-binding site [chemical binding]; other site 1191061017226 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1191061017227 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1191061017228 putative active site [active] 1191061017229 ferredoxin-NADP reductase; Provisional; Region: PRK10926 1191061017230 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1191061017231 FAD binding pocket [chemical binding]; other site 1191061017232 FAD binding motif [chemical binding]; other site 1191061017233 phosphate binding motif [ion binding]; other site 1191061017234 beta-alpha-beta structure motif; other site 1191061017235 NAD binding pocket [chemical binding]; other site 1191061017236 Predicted membrane protein [Function unknown]; Region: COG3152 1191061017237 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 1191061017238 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1191061017239 triosephosphate isomerase; Provisional; Region: PRK14567 1191061017240 substrate binding site [chemical binding]; other site 1191061017241 dimer interface [polypeptide binding]; other site 1191061017242 catalytic triad [active] 1191061017243 transmembrane helices; other site 1191061017244 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1191061017245 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1191061017246 CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471 1191061017247 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1191061017248 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1191061017249 substrate binding pocket [chemical binding]; other site 1191061017250 membrane-bound complex binding site; other site 1191061017251 septal ring assembly protein ZapB; Provisional; Region: PRK15422 1191061017252 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1191061017253 amphipathic channel; other site 1191061017254 Asn-Pro-Ala signature motifs; other site 1191061017255 glycerol kinase; Provisional; Region: glpK; PRK00047 1191061017256 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1191061017257 N- and C-terminal domain interface [polypeptide binding]; other site 1191061017258 active site 1191061017259 MgATP binding site [chemical binding]; other site 1191061017260 catalytic site [active] 1191061017261 metal binding site [ion binding]; metal-binding site 1191061017262 glycerol binding site [chemical binding]; other site 1191061017263 homotetramer interface [polypeptide binding]; other site 1191061017264 homodimer interface [polypeptide binding]; other site 1191061017265 FBP binding site [chemical binding]; other site 1191061017266 protein IIAGlc interface [polypeptide binding]; other site 1191061017267 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 1191061017268 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 1191061017269 AsmA family; Region: AsmA; pfam05170 1191061017270 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1191061017271 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 1191061017272 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1191061017273 active site turn [active] 1191061017274 phosphorylation site [posttranslational modification] 1191061017275 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1191061017276 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1191061017277 NAD(P) binding site [chemical binding]; other site 1191061017278 LDH/MDH dimer interface [polypeptide binding]; other site 1191061017279 substrate binding site [chemical binding]; other site 1191061017280 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1191061017281 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1191061017282 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1191061017283 putative active site [active] 1191061017284 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 1191061017285 fructokinase; Reviewed; Region: PRK09557 1191061017286 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1191061017287 nucleotide binding site [chemical binding]; other site 1191061017288 Glucokinase; Region: Glucokinase; cl17310 1191061017289 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1191061017290 intersubunit interface [polypeptide binding]; other site 1191061017291 active site 1191061017292 zinc binding site [ion binding]; other site 1191061017293 Na+ binding site [ion binding]; other site 1191061017294 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1191061017295 intersubunit interface [polypeptide binding]; other site 1191061017296 active site 1191061017297 zinc binding site [ion binding]; other site 1191061017298 Na+ binding site [ion binding]; other site 1191061017299 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1191061017300 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1191061017301 active site 1191061017302 P-loop; other site 1191061017303 phosphorylation site [posttranslational modification] 1191061017304 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1191061017305 active site 1191061017306 phosphorylation site [posttranslational modification] 1191061017307 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1191061017308 HTH domain; Region: HTH_11; pfam08279 1191061017309 Mga helix-turn-helix domain; Region: Mga; pfam05043 1191061017310 PRD domain; Region: PRD; pfam00874 1191061017311 PRD domain; Region: PRD; pfam00874 1191061017312 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1191061017313 active site 1191061017314 P-loop; other site 1191061017315 phosphorylation site [posttranslational modification] 1191061017316 putative alpha-glucosidase; Provisional; Region: PRK10658 1191061017317 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1191061017318 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 1191061017319 active site 1191061017320 homotrimer interface [polypeptide binding]; other site 1191061017321 catalytic site [active] 1191061017322 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 1191061017323 putative transporter; Provisional; Region: PRK11462 1191061017324 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1191061017325 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 1191061017326 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 1191061017327 Divergent AAA domain; Region: AAA_4; pfam04326 1191061017328 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 1191061017329 Virulence protein [General function prediction only]; Region: COG3943 1191061017330 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 1191061017331 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1191061017332 active site 1191061017333 Shikimate kinase; Region: SKI; pfam01202 1191061017334 Protein of unknown function (DUF3237); Region: DUF3237; pfam11578 1191061017335 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1191061017336 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1191061017337 putative NAD(P) binding site [chemical binding]; other site 1191061017338 dimer interface [polypeptide binding]; other site 1191061017339 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1191061017340 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1191061017341 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1191061017342 putative NAD(P) binding site [chemical binding]; other site 1191061017343 putative substrate binding site [chemical binding]; other site 1191061017344 catalytic Zn binding site [ion binding]; other site 1191061017345 structural Zn binding site [ion binding]; other site 1191061017346 dimer interface [polypeptide binding]; other site 1191061017347 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1191061017348 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1191061017349 conserved cys residue [active] 1191061017350 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1191061017351 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1191061017352 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1191061017353 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 1191061017354 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1191061017355 dimer interface [polypeptide binding]; other site 1191061017356 ADP-ribose binding site [chemical binding]; other site 1191061017357 active site 1191061017358 nudix motif; other site 1191061017359 metal binding site [ion binding]; metal-binding site 1191061017360 EamA-like transporter family; Region: EamA; pfam00892 1191061017361 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 1191061017362 lipoprotein, YaeC family; Region: TIGR00363 1191061017363 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 1191061017364 SnoaL-like domain; Region: SnoaL_2; pfam12680 1191061017365 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1191061017366 transcriptional regulator; Provisional; Region: PRK10632 1191061017367 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061017368 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 1191061017369 putative effector binding pocket; other site 1191061017370 putative dimerization interface [polypeptide binding]; other site 1191061017371 potential frameshift: common BLAST hit: gi|375258051|ref|YP_005017221.1| drug resistance transporter EmrB/QacA subfamily protein 1191061017372 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061017373 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061017374 putative substrate translocation pore; other site 1191061017375 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1191061017376 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1191061017377 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1191061017378 Coenzyme A binding pocket [chemical binding]; other site 1191061017379 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1191061017380 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1191061017381 HlyD family secretion protein; Region: HlyD_3; pfam13437 1191061017382 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1191061017383 Protein export membrane protein; Region: SecD_SecF; cl14618 1191061017384 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 1191061017385 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1191061017386 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061017387 putative substrate translocation pore; other site 1191061017388 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1191061017389 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1191061017390 putative active site [active] 1191061017391 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1191061017392 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1191061017393 active site turn [active] 1191061017394 phosphorylation site [posttranslational modification] 1191061017395 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1191061017396 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 1191061017397 CcdB protein; Region: CcdB; pfam01845 1191061017398 EamA-like transporter family; Region: EamA; pfam00892 1191061017399 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1191061017400 GT1, myb-like, SANT family; Region: GT1; cl17727 1191061017401 hypothetical protein; Provisional; Region: PRK09956 1191061017402 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1191061017403 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1191061017404 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1191061017405 DNA binding site [nucleotide binding] 1191061017406 domain linker motif; other site 1191061017407 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1191061017408 ligand binding site [chemical binding]; other site 1191061017409 dimerization interface [polypeptide binding]; other site 1191061017410 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1191061017411 active site 1191061017412 P-loop; other site 1191061017413 phosphorylation site [posttranslational modification] 1191061017414 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1191061017415 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1191061017416 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1191061017417 methionine cluster; other site 1191061017418 active site 1191061017419 phosphorylation site [posttranslational modification] 1191061017420 metal binding site [ion binding]; metal-binding site 1191061017421 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1191061017422 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1191061017423 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061017424 dimer interface [polypeptide binding]; other site 1191061017425 conserved gate region; other site 1191061017426 putative PBP binding loops; other site 1191061017427 ABC-ATPase subunit interface; other site 1191061017428 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 1191061017429 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061017430 dimer interface [polypeptide binding]; other site 1191061017431 conserved gate region; other site 1191061017432 putative PBP binding loops; other site 1191061017433 ABC-ATPase subunit interface; other site 1191061017434 2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; Region: PhnT; TIGR03258 1191061017435 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1191061017436 Walker A/P-loop; other site 1191061017437 ATP binding site [chemical binding]; other site 1191061017438 Q-loop/lid; other site 1191061017439 ABC transporter signature motif; other site 1191061017440 Walker B; other site 1191061017441 D-loop; other site 1191061017442 H-loop/switch region; other site 1191061017443 TOBE domain; Region: TOBE_2; pfam08402 1191061017444 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 1191061017445 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1191061017446 transcriptional regulator protein; Region: phnR; TIGR03337 1191061017447 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1191061017448 DNA-binding site [nucleotide binding]; DNA binding site 1191061017449 UTRA domain; Region: UTRA; pfam07702 1191061017450 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 1191061017451 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1191061017452 catalytic residue [active] 1191061017453 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 1191061017454 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1191061017455 motif II; other site 1191061017456 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1191061017457 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 1191061017458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061017459 putative substrate translocation pore; other site 1191061017460 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1191061017461 non-specific DNA binding site [nucleotide binding]; other site 1191061017462 salt bridge; other site 1191061017463 sequence-specific DNA binding site [nucleotide binding]; other site 1191061017464 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 1191061017465 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 1191061017466 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061017467 putative substrate translocation pore; other site 1191061017468 regulatory protein UhpC; Provisional; Region: PRK11663 1191061017469 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061017470 putative substrate translocation pore; other site 1191061017471 sensory histidine kinase UhpB; Provisional; Region: PRK11644 1191061017472 MASE1; Region: MASE1; pfam05231 1191061017473 Histidine kinase; Region: HisKA_3; pfam07730 1191061017474 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191061017475 ATP binding site [chemical binding]; other site 1191061017476 Mg2+ binding site [ion binding]; other site 1191061017477 G-X-G motif; other site 1191061017478 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 1191061017479 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1191061017480 active site 1191061017481 phosphorylation site [posttranslational modification] 1191061017482 intermolecular recognition site; other site 1191061017483 dimerization interface [polypeptide binding]; other site 1191061017484 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1191061017485 DNA binding residues [nucleotide binding] 1191061017486 dimerization interface [polypeptide binding]; other site 1191061017487 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 1191061017488 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1191061017489 putative valine binding site [chemical binding]; other site 1191061017490 dimer interface [polypeptide binding]; other site 1191061017491 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 1191061017492 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1191061017493 PYR/PP interface [polypeptide binding]; other site 1191061017494 dimer interface [polypeptide binding]; other site 1191061017495 TPP binding site [chemical binding]; other site 1191061017496 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1191061017497 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1191061017498 TPP-binding site [chemical binding]; other site 1191061017499 dimer interface [polypeptide binding]; other site 1191061017500 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1191061017501 Coenzyme A binding pocket [chemical binding]; other site 1191061017502 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 1191061017503 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 1191061017504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061017505 putative substrate translocation pore; other site 1191061017506 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 1191061017507 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061017508 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1191061017509 dimerization interface [polypeptide binding]; other site 1191061017510 substrate binding pocket [chemical binding]; other site 1191061017511 permease DsdX; Provisional; Region: PRK09921 1191061017512 gluconate transporter; Region: gntP; TIGR00791 1191061017513 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 1191061017514 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1191061017515 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1191061017516 catalytic residue [active] 1191061017517 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 1191061017518 Domain of unknown function (DUF202); Region: DUF202; pfam02656 1191061017519 Predicted membrane protein [Function unknown]; Region: COG2149 1191061017520 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1191061017521 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 1191061017522 NAD binding site [chemical binding]; other site 1191061017523 sugar binding site [chemical binding]; other site 1191061017524 divalent metal binding site [ion binding]; other site 1191061017525 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1191061017526 dimer interface [polypeptide binding]; other site 1191061017527 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 1191061017528 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 1191061017529 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1191061017530 active site turn [active] 1191061017531 phosphorylation site [posttranslational modification] 1191061017532 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1191061017533 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1191061017534 DNA-binding site [nucleotide binding]; DNA binding site 1191061017535 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1191061017536 putative transporter; Validated; Region: PRK03818 1191061017537 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1191061017538 TrkA-C domain; Region: TrkA_C; pfam02080 1191061017539 TrkA-C domain; Region: TrkA_C; pfam02080 1191061017540 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1191061017541 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1191061017542 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1191061017543 putative dimer interface [polypeptide binding]; other site 1191061017544 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1191061017545 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1191061017546 putative dimer interface [polypeptide binding]; other site 1191061017547 hypothetical protein; Provisional; Region: PRK11616 1191061017548 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 1191061017549 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061017550 D-galactonate transporter; Region: 2A0114; TIGR00893 1191061017551 putative substrate translocation pore; other site 1191061017552 galactonate dehydratase; Provisional; Region: PRK14017 1191061017553 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 1191061017554 putative active site pocket [active] 1191061017555 putative metal binding site [ion binding]; other site 1191061017556 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 1191061017557 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1191061017558 active site 1191061017559 intersubunit interface [polypeptide binding]; other site 1191061017560 catalytic residue [active] 1191061017561 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 1191061017562 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 1191061017563 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1191061017564 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1191061017565 DNA-binding site [nucleotide binding]; DNA binding site 1191061017566 FCD domain; Region: FCD; pfam07729 1191061017567 sugar phosphate phosphatase; Provisional; Region: PRK10513 1191061017568 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1191061017569 active site 1191061017570 motif I; other site 1191061017571 motif II; other site 1191061017572 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1191061017573 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 1191061017574 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1191061017575 putative NAD(P) binding site [chemical binding]; other site 1191061017576 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1191061017577 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061017578 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 1191061017579 putative effector binding pocket; other site 1191061017580 putative dimerization interface [polypeptide binding]; other site 1191061017581 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1191061017582 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1191061017583 Mg2+ binding site [ion binding]; other site 1191061017584 G-X-G motif; other site 1191061017585 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1191061017586 anchoring element; other site 1191061017587 dimer interface [polypeptide binding]; other site 1191061017588 ATP binding site [chemical binding]; other site 1191061017589 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1191061017590 active site 1191061017591 putative metal-binding site [ion binding]; other site 1191061017592 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1191061017593 recF protein; Region: recf; TIGR00611 1191061017594 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1191061017595 Walker A/P-loop; other site 1191061017596 ATP binding site [chemical binding]; other site 1191061017597 Q-loop/lid; other site 1191061017598 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1191061017599 ABC transporter signature motif; other site 1191061017600 Walker B; other site 1191061017601 D-loop; other site 1191061017602 H-loop/switch region; other site 1191061017603 DNA polymerase III subunit beta; Validated; Region: PRK05643 1191061017604 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1191061017605 putative DNA binding surface [nucleotide binding]; other site 1191061017606 dimer interface [polypeptide binding]; other site 1191061017607 beta-clamp/clamp loader binding surface; other site 1191061017608 beta-clamp/translesion DNA polymerase binding surface; other site 1191061017609 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1191061017610 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1191061017611 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191061017612 Walker A motif; other site 1191061017613 ATP binding site [chemical binding]; other site 1191061017614 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1191061017615 Walker B motif; other site 1191061017616 arginine finger; other site 1191061017617 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1191061017618 DnaA box-binding interface [nucleotide binding]; other site 1191061017619 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1191061017620 ribonuclease P; Reviewed; Region: rnpA; PRK01732 1191061017621 membrane protein insertase; Provisional; Region: PRK01318 1191061017622 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1191061017623 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1191061017624 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1191061017625 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1191061017626 G1 box; other site 1191061017627 GTP/Mg2+ binding site [chemical binding]; other site 1191061017628 Switch I region; other site 1191061017629 G2 box; other site 1191061017630 Switch II region; other site 1191061017631 G3 box; other site 1191061017632 G4 box; other site 1191061017633 G5 box; other site 1191061017634 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1191061017635 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1191061017636 Coenzyme A binding pocket [chemical binding]; other site 1191061017637 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 1191061017638 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061017639 putative substrate translocation pore; other site 1191061017640 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 1191061017641 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1191061017642 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1191061017643 substrate binding pocket [chemical binding]; other site 1191061017644 dimerization interface [polypeptide binding]; other site 1191061017645 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1191061017646 Predicted flavoprotein [General function prediction only]; Region: COG0431 1191061017647 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1191061017648 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1191061017649 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 1191061017650 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1191061017651 active site 1191061017652 motif I; other site 1191061017653 motif II; other site 1191061017654 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1191061017655 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1191061017656 active site 1191061017657 trimer interface [polypeptide binding]; other site 1191061017658 allosteric site; other site 1191061017659 active site lid [active] 1191061017660 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1191061017661 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 1191061017662 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 1191061017663 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1191061017664 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 1191061017665 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1191061017666 trimer interface; other site 1191061017667 sugar binding site [chemical binding]; other site 1191061017668 transcriptional regulator PhoU; Provisional; Region: PRK11115 1191061017669 PhoU domain; Region: PhoU; pfam01895 1191061017670 PhoU domain; Region: PhoU; pfam01895 1191061017671 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 1191061017672 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1191061017673 Walker A/P-loop; other site 1191061017674 ATP binding site [chemical binding]; other site 1191061017675 Q-loop/lid; other site 1191061017676 ABC transporter signature motif; other site 1191061017677 Walker B; other site 1191061017678 D-loop; other site 1191061017679 H-loop/switch region; other site 1191061017680 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 1191061017681 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061017682 dimer interface [polypeptide binding]; other site 1191061017683 conserved gate region; other site 1191061017684 putative PBP binding loops; other site 1191061017685 ABC-ATPase subunit interface; other site 1191061017686 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 1191061017687 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1191061017688 dimer interface [polypeptide binding]; other site 1191061017689 conserved gate region; other site 1191061017690 putative PBP binding loops; other site 1191061017691 ABC-ATPase subunit interface; other site 1191061017692 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1191061017693 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1191061017694 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1191061017695 glutaminase active site [active] 1191061017696 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1191061017697 dimer interface [polypeptide binding]; other site 1191061017698 active site 1191061017699 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1191061017700 dimer interface [polypeptide binding]; other site 1191061017701 active site 1191061017702 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 1191061017703 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1191061017704 Substrate binding site; other site 1191061017705 Mg++ binding site; other site 1191061017706 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1191061017707 active site 1191061017708 substrate binding site [chemical binding]; other site 1191061017709 CoA binding site [chemical binding]; other site 1191061017710 Right handed beta helix region; Region: Beta_helix; pfam13229 1191061017711 aspartate aminotransferase; Provisional; Region: PRK07568 1191061017712 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1191061017713 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1191061017714 gamma subunit interface [polypeptide binding]; other site 1191061017715 epsilon subunit interface [polypeptide binding]; other site 1191061017716 LBP interface [polypeptide binding]; other site 1191061017717 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1191061017718 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1191061017719 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1191061017720 alpha subunit interaction interface [polypeptide binding]; other site 1191061017721 Walker A motif; other site 1191061017722 ATP binding site [chemical binding]; other site 1191061017723 Walker B motif; other site 1191061017724 inhibitor binding site; inhibition site 1191061017725 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1191061017726 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1191061017727 core domain interface [polypeptide binding]; other site 1191061017728 delta subunit interface [polypeptide binding]; other site 1191061017729 epsilon subunit interface [polypeptide binding]; other site 1191061017730 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1191061017731 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1191061017732 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1191061017733 beta subunit interaction interface [polypeptide binding]; other site 1191061017734 Walker A motif; other site 1191061017735 ATP binding site [chemical binding]; other site 1191061017736 Walker B motif; other site 1191061017737 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1191061017738 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1191061017739 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1191061017740 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1191061017741 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1191061017742 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1191061017743 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1191061017744 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1191061017745 ATP synthase I chain; Region: ATP_synt_I; cl09170 1191061017746 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1191061017747 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1191061017748 S-adenosylmethionine binding site [chemical binding]; other site 1191061017749 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1191061017750 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1191061017751 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1191061017752 FMN-binding protein MioC; Provisional; Region: PRK09004 1191061017753 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 1191061017754 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1191061017755 putative DNA binding site [nucleotide binding]; other site 1191061017756 putative Zn2+ binding site [ion binding]; other site 1191061017757 AsnC family; Region: AsnC_trans_reg; pfam01037 1191061017758 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 1191061017759 dimer interface [polypeptide binding]; other site 1191061017760 active site 1191061017761 hypothetical protein; Provisional; Region: yieM; PRK10997 1191061017762 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 1191061017763 metal ion-dependent adhesion site (MIDAS); other site 1191061017764 regulatory ATPase RavA; Provisional; Region: PRK13531 1191061017765 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191061017766 Walker A motif; other site 1191061017767 ATP binding site [chemical binding]; other site 1191061017768 Walker B motif; other site 1191061017769 arginine finger; other site 1191061017770 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 1191061017771 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 1191061017772 potassium uptake protein; Region: kup; TIGR00794 1191061017773 D-ribose pyranase; Provisional; Region: PRK11797 1191061017774 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 1191061017775 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1191061017776 Walker A/P-loop; other site 1191061017777 ATP binding site [chemical binding]; other site 1191061017778 Q-loop/lid; other site 1191061017779 ABC transporter signature motif; other site 1191061017780 Walker B; other site 1191061017781 D-loop; other site 1191061017782 H-loop/switch region; other site 1191061017783 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1191061017784 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1191061017785 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1191061017786 TM-ABC transporter signature motif; other site 1191061017787 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1191061017788 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1191061017789 ligand binding site [chemical binding]; other site 1191061017790 dimerization interface [polypeptide binding]; other site 1191061017791 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1191061017792 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1191061017793 substrate binding site [chemical binding]; other site 1191061017794 dimer interface [polypeptide binding]; other site 1191061017795 ATP binding site [chemical binding]; other site 1191061017796 transcriptional repressor RbsR; Provisional; Region: PRK10423 1191061017797 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1191061017798 DNA binding site [nucleotide binding] 1191061017799 domain linker motif; other site 1191061017800 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 1191061017801 dimerization interface [polypeptide binding]; other site 1191061017802 ligand binding site [chemical binding]; other site 1191061017803 putative transporter; Provisional; Region: PRK10504 1191061017804 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061017805 putative substrate translocation pore; other site 1191061017806 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061017807 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1191061017808 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1191061017809 DNA-binding site [nucleotide binding]; DNA binding site 1191061017810 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1191061017811 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1191061017812 Walker A motif; other site 1191061017813 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1191061017814 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1191061017815 GTP binding site; other site 1191061017816 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 1191061017817 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1191061017818 serine/threonine protein kinase; Provisional; Region: PRK11768 1191061017819 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1191061017820 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1191061017821 catalytic residues [active] 1191061017822 hinge region; other site 1191061017823 alpha helical domain; other site 1191061017824 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1191061017825 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 1191061017826 putative acyl-acceptor binding pocket; other site 1191061017827 Initiator Replication protein; Region: Rep_3; pfam01051 1191061017828 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1191061017829 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1191061017830 Integrase core domain; Region: rve; pfam00665 1191061017831 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1191061017832 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 1191061017833 chromosome condensation membrane protein; Provisional; Region: PRK14196 1191061017834 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1191061017835 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1191061017836 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1191061017837 Universal stress protein family; Region: Usp; pfam00582 1191061017838 Ligand Binding Site [chemical binding]; other site 1191061017839 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1191061017840 Ligand Binding Site [chemical binding]; other site 1191061017841 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1191061017842 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1191061017843 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1191061017844 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1191061017845 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1191061017846 dimerization interface [polypeptide binding]; other site 1191061017847 putative DNA binding site [nucleotide binding]; other site 1191061017848 putative Zn2+ binding site [ion binding]; other site 1191061017849 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1191061017850 ArsC family; Region: ArsC; pfam03960 1191061017851 catalytic residues [active] 1191061017852 arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690 1191061017853 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1191061017854 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1191061017855 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1191061017856 Integrase core domain; Region: rve; pfam00665 1191061017857 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1191061017858 Integrase core domain; Region: rve; pfam00665 1191061017859 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 1191061017860 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 1191061017861 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1191061017862 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1191061017863 catalytic residues [active] 1191061017864 catalytic nucleophile [active] 1191061017865 Presynaptic Site I dimer interface [polypeptide binding]; other site 1191061017866 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1191061017867 Synaptic Flat tetramer interface [polypeptide binding]; other site 1191061017868 Synaptic Site I dimer interface [polypeptide binding]; other site 1191061017869 DNA binding site [nucleotide binding] 1191061017870 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1191061017871 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1191061017872 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1191061017873 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1191061017874 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1191061017875 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1191061017876 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1191061017877 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1191061017878 AAA domain; Region: AAA_18; pfam13238 1191061017879 active site 1191061017880 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 1191061017881 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1191061017882 Domain of unknown function (DUF3330); Region: DUF3330; pfam11809 1191061017883 putative mercury resistance protein; Provisional; Region: PRK13747 1191061017884 transcriptional regulator MerD; Provisional; Region: PRK13749 1191061017885 Helix-Turn-Helix DNA binding domain of the MerD transcription regulator; Region: HTH_MerD; cd01111 1191061017886 DNA binding residues [nucleotide binding] 1191061017887 putative dimer interface [polypeptide binding]; other site 1191061017888 putative mercuric reductase; Provisional; Region: PRK13748 1191061017889 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1191061017890 metal-binding site [ion binding] 1191061017891 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1191061017892 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1191061017893 putative mercury transport protein MerC; Provisional; Region: PRK13755 1191061017894 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1191061017895 metal-binding site [ion binding] 1191061017896 putative mercuric transport protein; Provisional; Region: PRK13751 1191061017897 putative transcriptional regulator MerR; Provisional; Region: PRK13752 1191061017898 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 1191061017899 DNA binding residues [nucleotide binding] 1191061017900 dimer interface [polypeptide binding]; other site 1191061017901 mercury binding site [ion binding]; other site 1191061017902 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 1191061017903 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1191061017904 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 1191061017905 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 1191061017906 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1191061017907 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1191061017908 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1191061017909 putative metal binding site [ion binding]; other site 1191061017910 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1191061017911 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1191061017912 putative metal binding site [ion binding]; other site 1191061017913 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 1191061017914 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1191061017915 putative metal binding site [ion binding]; other site 1191061017916 tellurite resistance protein terB; Region: terB; cd07176 1191061017917 putative metal binding site [ion binding]; other site 1191061017918 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1191061017919 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1191061017920 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1191061017921 putative metal binding site [ion binding]; other site 1191061017922 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1191061017923 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1191061017924 putative metal binding site [ion binding]; other site 1191061017925 Bacterial stress protein; Region: TerD; pfam02342 1191061017926 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1191061017927 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1191061017928 Transposase domain (DUF772); Region: DUF772; pfam05598 1191061017929 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1191061017930 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1191061017931 Homeodomain-like domain; Region: HTH_23; pfam13384 1191061017932 Winged helix-turn helix; Region: HTH_29; pfam13551 1191061017933 Homeodomain-like domain; Region: HTH_32; pfam13565 1191061017934 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1191061017935 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1191061017936 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1191061017937 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1191061017938 Transposase domain (DUF772); Region: DUF772; pfam05598 1191061017939 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1191061017940 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1191061017941 Protein of unknown function (DUF1173); Region: DUF1173; pfam06666 1191061017942 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 1191061017943 PLD-like domain; Region: PLDc_2; pfam13091 1191061017944 putative homodimer interface [polypeptide binding]; other site 1191061017945 putative active site [active] 1191061017946 catalytic site [active] 1191061017947 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 1191061017948 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1191061017949 Winged helix-turn helix; Region: HTH_29; pfam13551 1191061017950 Helix-turn-helix domain; Region: HTH_28; pfam13518 1191061017951 Homeodomain-like domain; Region: HTH_32; pfam13565 1191061017952 Integrase core domain; Region: rve; pfam00665 1191061017953 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1191061017954 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1191061017955 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1191061017956 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1191061017957 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 1191061017958 Conjugative relaxosome accessory transposon protein; Region: TraH; cl05580 1191061017959 F plasmid transfer operon protein; Region: TraF; pfam13728 1191061017960 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1191061017961 catalytic residues [active] 1191061017962 Putative helicase; Region: TraI_2; pfam07514 1191061017963 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 1191061017964 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 1191061017965 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 1191061017966 Domain of unknown function (DUF4400); Region: DUF4400; cl14023 1191061017967 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1191061017968 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1191061017969 tandem repeat interface [polypeptide binding]; other site 1191061017970 oligomer interface [polypeptide binding]; other site 1191061017971 active site residues [active] 1191061017972 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1191061017973 Integrase core domain; Region: rve; pfam00665 1191061017974 Integrase core domain; Region: rve_3; pfam13683 1191061017975 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 1191061017976 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1191061017977 active site 1191061017978 DNA binding site [nucleotide binding] 1191061017979 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1191061017980 AAA ATPase domain; Region: AAA_15; pfam13175 1191061017981 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1191061017982 putative active site [active] 1191061017983 putative metal-binding site [ion binding]; other site 1191061017984 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 1191061017985 active site 1191061017986 NTP binding site [chemical binding]; other site 1191061017987 metal binding triad [ion binding]; metal-binding site 1191061017988 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1191061017989 DNA binding site [nucleotide binding] 1191061017990 active site 1191061017991 Int/Topo IB signature motif; other site 1191061017992 catalytic residues [active] 1191061017993 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1191061017994 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1191061017995 Integrase core domain; Region: rve; pfam00665 1191061017996 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 1191061017997 PLD-like domain; Region: PLDc_2; pfam13091 1191061017998 putative active site [active] 1191061017999 catalytic site [active] 1191061018000 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1191061018001 Uncharacterized conserved protein [Function unknown]; Region: COG2361 1191061018002 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1191061018003 active site 1191061018004 NTP binding site [chemical binding]; other site 1191061018005 metal binding triad [ion binding]; metal-binding site 1191061018006 antibiotic binding site [chemical binding]; other site 1191061018007 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1191061018008 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1191061018009 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1191061018010 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1191061018011 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1191061018012 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1191061018013 catalytic residues [active] 1191061018014 catalytic nucleophile [active] 1191061018015 Presynaptic Site I dimer interface [polypeptide binding]; other site 1191061018016 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1191061018017 Synaptic Flat tetramer interface [polypeptide binding]; other site 1191061018018 Synaptic Site I dimer interface [polypeptide binding]; other site 1191061018019 DNA binding site [nucleotide binding] 1191061018020 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1191061018021 DNA-binding interface [nucleotide binding]; DNA binding site 1191061018022 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1191061018023 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1191061018024 Integrase core domain; Region: rve; pfam00665 1191061018025 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1191061018026 Ferritin-like domain; Region: Ferritin; pfam00210 1191061018027 dinuclear metal binding motif [ion binding]; other site 1191061018028 Transposase domain (DUF772); Region: DUF772; pfam05598 1191061018029 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1191061018030 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1191061018031 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1191061018032 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1191061018033 sequence-specific DNA binding site [nucleotide binding]; other site 1191061018034 salt bridge; other site 1191061018035 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1191061018036 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1191061018037 Integrase core domain; Region: rve; pfam00665 1191061018038 Initiator Replication protein; Region: Rep_3; pfam01051 1191061018039 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 1191061018040 putative active site [active] 1191061018041 putative substrate binding site [chemical binding]; other site 1191061018042 Phosphotransferase enzyme family; Region: APH; pfam01636 1191061018043 ATP binding site [chemical binding]; other site 1191061018044 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1191061018045 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1191061018046 ABC transporter; Region: ABC_tran_2; pfam12848 1191061018047 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1191061018048 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1191061018049 Ribosomal RNA methyltransferase (FmrO); Region: FmrO; pfam07091 1191061018050 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1191061018051 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 1191061018052 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1191061018053 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 1191061018054 Ribosomal protein S27; Region: Ribosomal_S27e; cl00897 1191061018055 Putative transposase; Region: Y2_Tnp; pfam04986 1191061018056 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1191061018057 dihydropteroate synthase; Region: DHPS; TIGR01496 1191061018058 substrate binding pocket [chemical binding]; other site 1191061018059 dimer interface [polypeptide binding]; other site 1191061018060 inhibitor binding site; inhibition site 1191061018061 aminoglycoside resistance protein; Provisional; Region: PRK13746 1191061018062 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1191061018063 active site 1191061018064 NTP binding site [chemical binding]; other site 1191061018065 metal binding triad [ion binding]; metal-binding site 1191061018066 antibiotic binding site [chemical binding]; other site 1191061018067 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 1191061018068 Protein of unknown function (DUF1010); Region: DUF1010; pfam06231 1191061018069 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1191061018070 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1191061018071 folate binding site [chemical binding]; other site 1191061018072 NADP+ binding site [chemical binding]; other site 1191061018073 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1191061018074 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 1191061018075 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1191061018076 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1191061018077 catalytic residues [active] 1191061018078 catalytic nucleophile [active] 1191061018079 Presynaptic Site I dimer interface [polypeptide binding]; other site 1191061018080 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1191061018081 Synaptic Flat tetramer interface [polypeptide binding]; other site 1191061018082 Synaptic Site I dimer interface [polypeptide binding]; other site 1191061018083 DNA binding site [nucleotide binding] 1191061018084 Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796 1191061018085 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 1191061018086 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 1191061018087 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1191061018088 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1191061018089 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1191061018090 Coenzyme A binding pocket [chemical binding]; other site 1191061018091 integrase/recombinase; Provisional; Region: PRK15417 1191061018092 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 1191061018093 Int/Topo IB signature motif; other site 1191061018094 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1191061018095 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1191061018096 catalytic residues [active] 1191061018097 catalytic nucleophile [active] 1191061018098 Presynaptic Site I dimer interface [polypeptide binding]; other site 1191061018099 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1191061018100 Synaptic Flat tetramer interface [polypeptide binding]; other site 1191061018101 Synaptic Site I dimer interface [polypeptide binding]; other site 1191061018102 DNA binding site [nucleotide binding] 1191061018103 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1191061018104 DNA-binding interface [nucleotide binding]; DNA binding site 1191061018105 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 1191061018106 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 1191061018107 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1191061018108 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1191061018109 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1191061018110 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 1191061018111 DNA binding site [nucleotide binding] 1191061018112 dimer interface [polypeptide binding]; other site 1191061018113 active site 1191061018114 Int/Topo IB signature motif; other site 1191061018115 DNA replication terminus site-binding protein (Ter protein); Region: Ter; cl11502 1191061018116 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 1191061018117 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1191061018118 Toprim domain; Region: Toprim_3; pfam13362 1191061018119 Mitochondrial ribosomal protein L37; Region: Ribosomal_L37; pfam08561 1191061018120 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1191061018121 metal ion-dependent adhesion site (MIDAS); other site 1191061018122 Protein of unknown function (DUF3150); Region: DUF3150; pfam11348 1191061018123 TraU protein; Region: TraU; pfam06834 1191061018124 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; cl09883 1191061018125 Sex factor F TraW protein N terminal; Region: TraW_N; cl10149 1191061018126 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 1191061018127 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 1191061018128 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 1191061018129 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 1191061018130 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1191061018131 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1191061018132 active site 1191061018133 metal binding site [ion binding]; metal-binding site 1191061018134 type IV conjugative transfer system lipoprotein TraV; Region: TraV; TIGR02747 1191061018135 Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676 1191061018136 TraK protein; Region: TraK; pfam06586 1191061018137 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1191061018138 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1191061018139 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1191061018140 Magnesium ion binding site [ion binding]; other site 1191061018141 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1191061018142 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 1191061018143 CRISPR-associated protein, TIGR02710 family; Region: TIGR02710 1191061018144 Homeodomain-like domain; Region: HTH_23; pfam13384 1191061018145 Winged helix-turn helix; Region: HTH_29; pfam13551 1191061018146 Homeodomain-like domain; Region: HTH_32; pfam13565 1191061018147 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1191061018148 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1191061018149 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 1191061018150 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1191061018151 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1191061018152 Methyltransferase domain; Region: Methyltransf_27; pfam13708 1191061018153 mobile mystery protein A; Region: mob_myst_A; TIGR02612 1191061018154 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1191061018155 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1191061018156 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1191061018157 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1191061018158 Catalytic site [active] 1191061018159 Prokaryotic E2 family A; Region: Prok-E2_A; pfam14457 1191061018160 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 1191061018161 ATP binding site [chemical binding]; other site 1191061018162 Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464 1191061018163 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1191061018164 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1191061018165 Integrase core domain; Region: rve; pfam00665 1191061018166 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1191061018167 Resolvase, N terminal domain; Region: Resolvase; pfam00239 1191061018168 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1191061018169 DNA-binding interface [nucleotide binding]; DNA binding site 1191061018170 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1191061018171 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1191061018172 Integrase core domain; Region: rve; pfam00665 1191061018173 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1191061018174 DNA binding site [nucleotide binding] 1191061018175 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 1191061018176 FosA, a Fosfomycin resistance protein, catalyzes the addition of glutathione to the antibiotic fosfomycin, making it inactive; Region: FosA; cd07244 1191061018177 dimer interface [polypeptide binding]; other site 1191061018178 Mn binding site [ion binding]; other site 1191061018179 K binding site [ion binding]; other site 1191061018180 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1191061018181 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1191061018182 Integrase core domain; Region: rve; pfam00665 1191061018183 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1191061018184 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1191061018185 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1191061018186 beta-lactamase TEM; Provisional; Region: PRK15442 1191061018187 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1191061018188 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1191061018189 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1191061018190 Integrase core domain; Region: rve; pfam00665 1191061018191 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 1191061018192 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1191061018193 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1191061018194 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1191061018195 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 1191061018196 dihydropteroate synthase; Region: DHPS; TIGR01496 1191061018197 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1191061018198 substrate binding pocket [chemical binding]; other site 1191061018199 dimer interface [polypeptide binding]; other site 1191061018200 inhibitor binding site; inhibition site 1191061018201 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; pfam04655 1191061018202 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1191061018203 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1191061018204 catalytic residues [active] 1191061018205 catalytic nucleophile [active] 1191061018206 Presynaptic Site I dimer interface [polypeptide binding]; other site 1191061018207 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1191061018208 Synaptic Flat tetramer interface [polypeptide binding]; other site 1191061018209 Synaptic Site I dimer interface [polypeptide binding]; other site 1191061018210 DNA binding site [nucleotide binding] 1191061018211 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 1191061018212 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1191061018213 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1191061018214 catalytic residues [active] 1191061018215 catalytic nucleophile [active] 1191061018216 Presynaptic Site I dimer interface [polypeptide binding]; other site 1191061018217 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1191061018218 Synaptic Flat tetramer interface [polypeptide binding]; other site 1191061018219 Synaptic Site I dimer interface [polypeptide binding]; other site 1191061018220 DNA binding site [nucleotide binding] 1191061018221 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1191061018222 DNA-binding interface [nucleotide binding]; DNA binding site 1191061018223 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1191061018224 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1191061018225 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1191061018226 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1191061018227 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1191061018228 Integrase core domain; Region: rve; pfam00665 1191061018229 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1191061018230 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1191061018231 sequence-specific DNA binding site [nucleotide binding]; other site 1191061018232 salt bridge; other site 1191061018233 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 1191061018234 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1191061018235 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1191061018236 catalytic residues [active] 1191061018237 catalytic nucleophile [active] 1191061018238 Presynaptic Site I dimer interface [polypeptide binding]; other site 1191061018239 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1191061018240 Synaptic Flat tetramer interface [polypeptide binding]; other site 1191061018241 Synaptic Site I dimer interface [polypeptide binding]; other site 1191061018242 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1191061018243 DNA-binding interface [nucleotide binding]; DNA binding site 1191061018244 integrase/recombinase; Provisional; Region: PRK15417 1191061018245 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 1191061018246 Int/Topo IB signature motif; other site 1191061018247 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1191061018248 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1191061018249 folate binding site [chemical binding]; other site 1191061018250 NADP+ binding site [chemical binding]; other site 1191061018251 aminoglycoside resistance protein; Provisional; Region: PRK13746 1191061018252 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1191061018253 active site 1191061018254 NTP binding site [chemical binding]; other site 1191061018255 metal binding triad [ion binding]; metal-binding site 1191061018256 antibiotic binding site [chemical binding]; other site 1191061018257 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 1191061018258 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 1191061018259 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1191061018260 dihydropteroate synthase; Region: DHPS; TIGR01496 1191061018261 substrate binding pocket [chemical binding]; other site 1191061018262 dimer interface [polypeptide binding]; other site 1191061018263 inhibitor binding site; inhibition site 1191061018264 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 1191061018265 Ribosomal protein S27; Region: Ribosomal_S27e; cl00897 1191061018266 Putative transposase; Region: Y2_Tnp; pfam04986 1191061018267 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 1191061018268 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1191061018269 Ribosomal RNA methyltransferase (FmrO); Region: FmrO; pfam07091 1191061018270 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1191061018271 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1191061018272 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1191061018273 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1191061018274 ABC transporter; Region: ABC_tran_2; pfam12848 1191061018275 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1191061018276 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 1191061018277 putative active site [active] 1191061018278 putative substrate binding site [chemical binding]; other site 1191061018279 Phosphotransferase enzyme family; Region: APH; pfam01636 1191061018280 ATP binding site [chemical binding]; other site 1191061018281 Winged helix-turn helix; Region: HTH_29; pfam13551 1191061018282 Helix-turn-helix domain; Region: HTH_28; pfam13518 1191061018283 Homeodomain-like domain; Region: HTH_32; pfam13565 1191061018284 Integrase core domain; Region: rve; pfam00665 1191061018285 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1191061018286 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1191061018287 Catalytic site [active] 1191061018288 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 1191061018289 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1191061018290 active site 1191061018291 DNA binding site [nucleotide binding] 1191061018292 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1191061018293 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1191061018294 ParB-like nuclease domain; Region: ParB; smart00470 1191061018295 ParB family; Region: ParB; pfam08775 1191061018296 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1191061018297 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1191061018298 P-loop; other site 1191061018299 Magnesium ion binding site [ion binding]; other site 1191061018300 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1191061018301 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1191061018302 Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767 1191061018303 catalytic residues [active] 1191061018304 catalytic nucleophile [active] 1191061018305 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1191061018306 non-specific DNA binding site [nucleotide binding]; other site 1191061018307 salt bridge; other site 1191061018308 sequence-specific DNA binding site [nucleotide binding]; other site 1191061018309 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 1191061018310 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1191061018311 Homeodomain-like domain; Region: HTH_23; pfam13384 1191061018312 Winged helix-turn helix; Region: HTH_29; pfam13551 1191061018313 Homeodomain-like domain; Region: HTH_32; pfam13565 1191061018314 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1191061018315 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1191061018316 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 1191061018317 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 1191061018318 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 1191061018319 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 1191061018320 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1191061018321 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 1191061018322 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1191061018323 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 1191061018324 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 1191061018325 Truncated IS5 1191061018326 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1191061018327 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1191061018328 Integrase core domain; Region: rve; pfam00665 1191061018329 CHASE4 domain; Region: CHASE4; pfam05228 1191061018330 PAS domain S-box; Region: sensory_box; TIGR00229 1191061018331 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1191061018332 putative active site [active] 1191061018333 heme pocket [chemical binding]; other site 1191061018334 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1191061018335 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1191061018336 metal binding site [ion binding]; metal-binding site 1191061018337 active site 1191061018338 I-site; other site 1191061018339 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1191061018340 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1191061018341 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 1191061018342 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 1191061018343 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 1191061018344 plasmid maintenance protein CcdA; Provisional; Region: PRK13710 1191061018345 plasmid maintenance protein CcdB; Provisional; Region: PRK13708 1191061018346 major capsid L1 protein; Provisional; Region: PHA02778 1191061018347 Phage integrase family; Region: Phage_integrase; pfam00589 1191061018348 active site 1191061018349 DNA binding site [nucleotide binding] 1191061018350 Int/Topo IB signature motif; other site 1191061018351 putative transporter; Provisional; Region: PRK09821 1191061018352 GntP family permease; Region: GntP_permease; pfam02447 1191061018353 Transposase domain (DUF772); Region: DUF772; pfam05598 1191061018354 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1191061018355 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1191061018356 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1191061018357 HTH-like domain; Region: HTH_21; pfam13276 1191061018358 Integrase core domain; Region: rve; pfam00665 1191061018359 Integrase core domain; Region: rve_3; pfam13683 1191061018360 Transposase; Region: HTH_Tnp_1; pfam01527 1191061018361 putative resolvase 1191061018362 putative hypothetical protein 1191061018363 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1191061018364 Transposase domain (DUF772); Region: DUF772; pfam05598 1191061018365 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1191061018366 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1191061018367 truncated ISEhe like 1191061018368 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1191061018369 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1191061018370 ring oligomerisation interface [polypeptide binding]; other site 1191061018371 ATP/Mg binding site [chemical binding]; other site 1191061018372 stacking interactions; other site 1191061018373 hinge regions; other site 1191061018374 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1191061018375 oligomerisation interface [polypeptide binding]; other site 1191061018376 mobile loop; other site 1191061018377 roof hairpin; other site 1191061018378 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 1191061018379 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 1191061018380 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1191061018381 active site 1191061018382 BLMT, a bleomycin resistance protein encoded on the transposon Tn5, and similar proteins; Region: BLMT_like; cd08350 1191061018383 dimer interface [polypeptide binding]; other site 1191061018384 ligand binding site [chemical binding]; other site 1191061018385 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1191061018386 Truncated ISABa125_tpnA; Missin the N-terminal region of tpnA 1191061018387 Ribosomal RNA methyltransferase (FmrO); Region: FmrO; pfam07091 1191061018388 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 1191061018389 Putative transposase; Region: Y2_Tnp; pfam04986 1191061018390 Integrase core domain; Region: rve; pfam00665 1191061018391 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1191061018392 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1191061018393 AAA domain; Region: AAA_22; pfam13401 1191061018394 Walker A motif; other site 1191061018395 ATP binding site [chemical binding]; other site 1191061018396 Walker B motif; other site 1191061018397 arginine finger; other site 1191061018398 TniQ; Region: TniQ; pfam06527 1191061018399 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1191061018400 dihydropteroate synthase; Region: DHPS; TIGR01496 1191061018401 substrate binding pocket [chemical binding]; other site 1191061018402 dimer interface [polypeptide binding]; other site 1191061018403 inhibitor binding site; inhibition site 1191061018404 Predicted transcriptional regulator [Transcription]; Region: COG3905 1191061018405 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1191061018406 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1191061018407 putative hypothetical protein 1191061018408 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1191061018409 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1191061018410 minor groove reading motif; other site 1191061018411 helix-hairpin-helix signature motif; other site 1191061018412 substrate binding pocket [chemical binding]; other site 1191061018413 active site 1191061018414 Transposase domain (DUF772); Region: DUF772; pfam05598 1191061018415 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1191061018416 DDE superfamily endonuclease; Region: DDE_4; cl17710 1191061018417 Transposase domain (DUF772); Region: DUF772; pfam05598 1191061018418 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1191061018419 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1191061018420 Restriction endonuclease; Region: Mrr_cat; pfam04471 1191061018421 Protein of unknown function (DUF2913); Region: DUF2913; pfam11140 1191061018422 putative hypothetical protein 1191061018423 putative hypothetical protein 1191061018424 putative hypothetical protein 1191061018425 putative hypothetical protein 1191061018426 replication protein; Provisional; Region: PRK13750 1191061018427 replication protein; Provisional; Region: PRK13702 1191061018428 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 1191061018429 PLD-like domain; Region: PLDc_2; pfam13091 1191061018430 putative active site [active] 1191061018431 catalytic site [active] 1191061018432 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1191061018433 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 1191061018434 catalytic residues [active] 1191061018435 conjugal transfer fertility inhibition protein FinO; Provisional; Region: PRK13754 1191061018436 Fertility inhibition protein N terminal; Region: FinO_N; pfam12602 1191061018437 ProQ/FINO family; Region: ProQ; pfam04352 1191061018438 TraX protein; Region: TraX; cl05434 1191061018439 conjugal transfer nickase/helicase TraI; Provisional; Region: PRK13709 1191061018440 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 1191061018441 AAA domain; Region: AAA_30; pfam13604 1191061018442 DNA helicase TraI; Region: TraI; pfam07057 1191061018443 conjugal transfer protein TraD; Provisional; Region: PRK13700 1191061018444 F sex factor protein N terminal; Region: TraD_N; pfam12615 1191061018445 Bacterial conjugation protein TrwB, ATP binding domain. TrwB is a homohexamer encoded by conjugative plasmids in Gram-negative bacteria. TrwB also has an all alpha domain which has been hypothesized to be responsible for DNA binding. TrwB is a component...; Region: TrwB; cd01127 1191061018446 multimer interface [polypeptide binding]; other site 1191061018447 Walker A motif; other site 1191061018448 ATP binding site [chemical binding]; other site 1191061018449 Walker B motif; other site 1191061018450 conjugal transfer mating pair stabilization protein TraG; Provisional; Region: PRK13735 1191061018451 conjugal transfer pilus assembly protein TraH; Provisional; Region: PRK13723 1191061018452 conjugal transfer protein TrbF; Provisional; Region: PRK13743 1191061018453 conjugal transfer protein TrbB; Provisional; Region: PRK13728 1191061018454 Type-F conjugative transfer system pilin chaperone (TraQ); Region: TraQ; pfam09679 1191061018455 conjugal pilus assembly protein TraF; Provisional; Region: PRK13703 1191061018456 F plasmid transfer operon protein; Region: TraF; pfam13728 1191061018457 Conjugal transfer protein TrbE; Region: TrbE; cl10142 1191061018458 conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355 1191061018459 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; cl09883 1191061018460 conjugal transfer pilus assembly protein TraU; Provisional; Region: PRK13737 1191061018461 conjugal transfer pilus assembly protein TraW; Provisional; Region: PRK13738 1191061018462 type-F conjugative transfer system protein TrbI; Region: TrbI_Ftype; TIGR02744 1191061018463 conjugal transfer ATP-binding protein TraC; Provisional; Region: PRK13721 1191061018464 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 1191061018465 TraP protein; Region: TraP; cl11652 1191061018466 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1191061018467 conjugal transfer protein TraV; Provisional; Region: PRK13733 1191061018468 Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676 1191061018469 conjugal transfer pilus assembly protein TraB; Provisional; Region: PRK13729 1191061018470 Cytochrome b562; Region: Cytochrom_B562; cl01546 1191061018471 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 1191061018472 conjugal transfer protein TraK; Provisional; Region: PRK13736 1191061018473 TraK protein; Region: TraK; pfam06586 1191061018474 conjugal transfer pilus assembly protein TraE; Provisional; Region: PRK13726 1191061018475 conjugal transfer pilus assembly protein TraL; Provisional; Region: PRK13707 1191061018476 conjugal transfer pilin subunit TraA; Provisional; Region: PRK13734 1191061018477 TraY domain; Region: TraY; cl17675 1191061018478 putative hypothetical protein 1191061018479 TraM protein; Region: Tra_M; cl11621 1191061018480 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1191061018481 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1191061018482 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1191061018483 catalytic residue [active] 1191061018484 Antirestriction protein; Region: Antirestrict; pfam03230 1191061018485 putative hypothetical protein 1191061018486 putative hypothetical protein 1191061018487 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1191061018488 putative hypothetical protein 1191061018489 PsiA protein; Region: PsiA; cl11646 1191061018490 Plasmid SOS inhibition protein (PsiB); Region: PsiB; pfam06290 1191061018491 ParB-like nuclease domain; Region: ParBc; pfam02195 1191061018492 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1191061018493 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 1191061018494 putative hypothetical protein 1191061018495 putative hypothetical protein 1191061018496 DNA polymerase III, theta subunit; Region: DNA_pol3_theta; cl11635 1191061018497 Antirestriction protein (ArdA); Region: ArdA; cl01953 1191061018498 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 1191061018499 DNA methylase; Region: N6_N4_Mtase; cl17433 1191061018500 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1191061018501 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 1191061018502 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1191061018503 Transposase; Region: DDE_Tnp_ISL3; pfam01610