-- dump date   	20140619_121232
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1125630000001	RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468
1125630000002	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1125630000003	Walker A motif; other site
1125630000004	ATP binding site [chemical binding]; other site
1125630000005	Walker B motif; other site
1125630000006	PIN domain of bacteriophage T3, T4 RNase H, T5-5'nuclease, and homologs; Region: PIN_T4-like; cd09860
1125630000007	5'-3' exonuclease; Region: 53EXOc; smart00475
1125630000008	active site
1125630000009	metal binding site 1 [ion binding]; metal-binding site
1125630000010	5' ssDNA interaction site; other site
1125630000011	3' ssDNA interaction site; other site
1125630000012	metal binding site 2 [ion binding]; metal-binding site
1125630000013	H3TH domain of bacteriophage T3, T4 RNase H, T5-5' nucleases, and homologs; Region: H3TH_T4-like; cd09899
1125630000014	DNA binding site [nucleotide binding]
1125630000015	metal binding site [ion binding]; metal-binding site
1125630000016	potential frameshift: common BLAST hit: gi|294502044|ref|YP_003565781.1| DNA polymerase III
1125630000017	Uracil DNA glycosylase superfamily; Region: UDG; pfam03167
1125630000018	PHP domain; Region: PHP; pfam02811
1125630000019	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
1125630000020	active site
1125630000021	PHP Thumb interface [polypeptide binding]; other site
1125630000022	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
1125630000023	Helix-hairpin-helix motif; Region: HHH_6; pfam14579
1125630000024	potential frameshift: common BLAST hit: gi|294502045|ref|YP_003565782.1| porphyrin biosynthetic protein
1125630000025	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944
1125630000026	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
1125630000027	Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase) [Coenzyme metabolism]; Region: CobT; COG4547
1125630000028	putative protease; Region: PHA00666
1125630000029	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1125630000030	metal ion-dependent adhesion site (MIDAS); other site
1125630000031	Helix-turn-helix domain; Region: HTH_19; pfam12844
1125630000032	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1125630000033	active site
1125630000034	DNA binding site [nucleotide binding]
1125630000035	Int/Topo IB signature motif; other site
1125630000036	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1125630000037	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1125630000038	putative active site [active]
1125630000039	putative NTP binding site [chemical binding]; other site
1125630000040	putative nucleic acid binding site [nucleotide binding]; other site
1125630000041	Toxin YafO, type II toxin-antitoxin system; Region: YafO_toxin; cl08066
1125630000042	Exocyst complex component Sec6; Region: Sec6; cl19885
1125630000043	Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066
1125630000044	GSH binding site [chemical binding]; other site
1125630000045	catalytic residues [active]
1125630000046	PhoH-like protein; Region: PhoH; cl17668
1125630000047	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
1125630000048	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
1125630000049	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1125630000050	multiple promoter invertase; Provisional; Region: mpi; PRK13413
1125630000051	catalytic residues [active]
1125630000052	catalytic nucleophile [active]
1125630000053	Presynaptic Site I dimer interface [polypeptide binding]; other site
1125630000054	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1125630000055	Synaptic Flat tetramer interface [polypeptide binding]; other site
1125630000056	Synaptic Site I dimer interface [polypeptide binding]; other site
1125630000057	DNA binding site [nucleotide binding]
1125630000058	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569
1125630000059	DNA-binding interface [nucleotide binding]; DNA binding site
1125630000060	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1125630000061	PAS fold; Region: PAS_3; pfam08447
1125630000062	putative active site [active]
1125630000063	heme pocket [chemical binding]; other site
1125630000064	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
1125630000065	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1125630000066	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
1125630000067	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191
1125630000068	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
1125630000069	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1125630000070	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1125630000071	dimerization interface [polypeptide binding]; other site
1125630000072	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1125630000073	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1125630000074	dimer interface [polypeptide binding]; other site
1125630000075	putative CheW interface [polypeptide binding]; other site
1125630000076	DNA ligase; Provisional; Region: 30; PHA02587
1125630000077	Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015
1125630000078	active site
1125630000079	The Oligonucleotide/oligosaccharide binding (OB)-fold domain is a DNA-binding module that is part of the catalytic core unit of ATP dependent DNA ligases; Region: OBF_DNA_ligase_family; cl08424
1125630000080	DNA binding site [nucleotide binding]
1125630000081	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1125630000082	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
1125630000083	active site
1125630000084	metal binding site [ion binding]; metal-binding site
1125630000085	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1125630000086	Walker A motif; other site
1125630000087	ATP binding site [chemical binding]; other site
1125630000088	Walker B motif; other site
1125630000089	ParA-like protein; Provisional; Region: PHA02518
1125630000090	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1125630000091	P-loop; other site
1125630000092	Magnesium ion binding site [ion binding]; other site
1125630000093	DNA ligase, NAD-dependent; Region: dnlj; TIGR00575
1125630000094	virion protein; Provisional; Region: V; PHA02564
1125630000095	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
1125630000096	potential frameshift: common BLAST hit: gi|375260349|ref|YP_005019519.1| gp24
1125630000097	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
1125630000098	Type IV secretion system proteins; Region: T4SS; cl19516
1125630000099	Domain of unknown function (DUF1983); Region: DUF1983; pfam09327
1125630000100	Fibronectin type III protein; Region: DUF3672; pfam12421
1125630000101	Domains similar to the Pancreatic-derived factor; Region: PANDER_like; cl19122
1125630000102	Phage-related protein, tail component [Function unknown]; Region: COG4733
1125630000103	Putative phage tail protein; Region: Phage-tail_3; pfam13550
1125630000104	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1125630000105	Interdomain contacts; other site
1125630000106	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
1125630000107	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
1125630000108	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
1125630000109	Phage-related protein, tail component [Function unknown]; Region: COG4723
1125630000110	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073
1125630000111	MPN+ (JAMM) motif; other site
1125630000112	Zinc-binding site [ion binding]; other site
1125630000113	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1125630000114	NlpC/P60 family; Region: NLPC_P60; pfam00877
1125630000115	Phage minor tail protein L; Region: Phage_tail_L; cl01908
1125630000116	Phage minor tail protein; Region: Phage_min_tail; cl01940
1125630000117	Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; cl19901
1125630000118	Mu-like prophage protein [General function prediction only]; Region: COG3941
1125630000119	tape measure domain; Region: tape_meas_nterm; TIGR02675
1125630000120	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
1125630000121	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
1125630000122	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
1125630000123	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
1125630000124	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
1125630000125	MAEBL; Provisional; Region: PTZ00121
1125630000126	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; cl19531
1125630000127	Terminase-like family; Region: Terminase_6; pfam03237
1125630000128	ABC-type ATPase fused to a predicted acetyltransferase domain [General function prediction only]; Region: COG2401
1125630000129	potential frameshift: common BLAST hit: gi|18466740|ref|NP_569547.1| putative ABC transporter ATP-binding protein
1125630000130	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1125630000131	ABC transporter signature motif; other site
1125630000132	Walker B; other site
1125630000133	D-loop; other site
1125630000134	H-loop/switch region; other site
1125630000135	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1125630000136	Walker A/P-loop; other site
1125630000137	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
1125630000138	ParB-like nuclease domain; Region: ParBc; pfam02195
1125630000139	Homocysteine S-methyltransferase; Region: S-methyl_trans; cl14105
1125630000140	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
1125630000141	ParB-like nuclease domain; Region: ParBc; pfam02195
1125630000142	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1125630000143	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1125630000144	ATP binding site [chemical binding]; other site
1125630000145	putative Mg++ binding site [ion binding]; other site
1125630000146	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1125630000147	nucleotide binding region [chemical binding]; other site
1125630000148	ATP-binding site [chemical binding]; other site
1125630000149	Repressor of phase-1 flagellin; Region: Flag1_repress; pfam03614
1125630000150	Protein of unknown function DUF262; Region: DUF262; pfam03235
1125630000151	Protein of unknown function DUF262; Region: DUF262; pfam03235
1125630000152	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
1125630000153	type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497
1125630000154	HsdM N-terminal domain; Region: HsdM_N; pfam12161
1125630000155	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1125630000156	S-adenosylmethionine binding site [chemical binding]; other site
1125630000157	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1125630000158	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1125630000159	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1125630000160	potential frameshift: common BLAST hit: gi|291289374|ref|YP_003517706.1| type I restriction-modification system restriction subunit R
1125630000161	potential frameshift: common BLAST hit: gi|215489626|ref|YP_002332057.1| type I restriction-modification enzyme R subunit
1125630000162	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
1125630000163	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
1125630000164	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1125630000165	ATP binding site [chemical binding]; other site
1125630000166	putative Mg++ binding site [ion binding]; other site
1125630000167	Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008
1125630000168	Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008
1125630000169	Protein of unknown function (DUF3927); Region: DUF3927; pfam13064
1125630000170	tellurite resistance protein terB; Region: terB; cd07176
1125630000171	putative metal binding site [ion binding]; other site
1125630000172	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
1125630000173	active site
1125630000174	RNA/DNA hybrid binding site [nucleotide binding]; other site
1125630000175	DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869
1125630000176	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
1125630000177	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1125630000178	active site
1125630000179	catalytic site [active]
1125630000180	substrate binding site [chemical binding]; other site
1125630000181	AAA domain; Region: AAA_17; pfam13207
1125630000182	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1125630000183	folate binding site [chemical binding]; other site
1125630000184	NADP+ binding site [chemical binding]; other site
1125630000185	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1125630000186	dimerization interface [polypeptide binding]; other site
1125630000187	active site
1125630000188	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231_like; cd11530
1125630000189	metal binding site [ion binding]; metal-binding site
1125630000190	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
1125630000191	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1125630000192	dimer interface [polypeptide binding]; other site
1125630000193	putative radical transfer pathway; other site
1125630000194	diiron center [ion binding]; other site
1125630000195	tyrosyl radical; other site
1125630000196	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103
1125630000197	ATP cone domain; Region: ATP-cone; pfam03477
1125630000198	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
1125630000199	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280
1125630000200	active site
1125630000201	putative DNA-binding cleft [nucleotide binding]; other site
1125630000202	dimer interface [polypeptide binding]; other site
1125630000203	potential frameshift: common BLAST hit: gi|294502029|ref|YP_003565766.1| putative exonuclease subunit 2
1125630000204	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
1125630000205	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1125630000206	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1125630000207	ABC transporter signature motif; other site
1125630000208	ABC transporter signature motif; other site
1125630000209	Walker B; other site
1125630000210	D-loop; other site
1125630000211	H-loop/switch region; other site
1125630000212	AAA domain; Region: AAA_23; pfam13476
1125630000213	Walker A/P-loop; other site
1125630000214	ATP binding site [chemical binding]; other site
1125630000215	Q-loop/lid; other site
1125630000216	ABC transporter signature motif; other site
1125630000217	DNA-directed DNA polymerase III (polc); Region: polc; TIGR00594
1125630000218	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
1125630000219	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1125630000220	active site
1125630000221	metal binding site [ion binding]; metal-binding site
1125630000222	Domain of unknown function (DUF4041); Region: DUF4041; pfam13250
1125630000223	This entry represents the putative helicase A859L; Region: T5orf172; smart00974
1125630000224	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
1125630000225	Ligand Binding Site [chemical binding]; other site
1125630000226	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
1125630000227	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
1125630000228	tandem repeat interface [polypeptide binding]; other site
1125630000229	oligomer interface [polypeptide binding]; other site
1125630000230	active site residues [active]
1125630000231	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
1125630000232	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
1125630000233	catalytic residues [active]
1125630000234	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1125630000235	Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]; Region: TEF1; COG5256
1125630000236	Staphylococcal nuclease homologues; Region: SNc; smart00318
1125630000237	Staphylococcal nuclease homologue; Region: SNase; pfam00565
1125630000238	histone-like DNA-binding protein HU; Region: HU; cd13831
1125630000239	dimer interface [polypeptide binding]; other site
1125630000240	DNA binding site [nucleotide binding]
1125630000241	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1125630000242	non-specific DNA binding site [nucleotide binding]; other site
1125630000243	salt bridge; other site
1125630000244	sequence-specific DNA binding site [nucleotide binding]; other site
1125630000245	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
1125630000246	Protein of unknown function (DUF1643); Region: DUF1643; pfam07799
1125630000247	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1125630000248	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1125630000249	Walker A motif; other site
1125630000250	ATP binding site [chemical binding]; other site
1125630000251	Walker B motif; other site
1125630000252	arginine finger; other site
1125630000253	VirB8 protein; Region: VirB8; cl01500
1125630000254	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
1125630000255	VirB7 interaction site; other site
1125630000256	Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948
1125630000257	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
1125630000258	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1125630000259	Walker A motif; other site
1125630000260	ATP binding site [chemical binding]; other site
1125630000261	Walker B motif; other site
1125630000262	Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170
1125630000263	PLD-like domain; Region: PLDc_2; pfam13091
1125630000264	putative active site [active]
1125630000265	catalytic site [active]
1125630000266	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1125630000267	dimerization interface [polypeptide binding]; other site
1125630000268	putative DNA binding site [nucleotide binding]; other site
1125630000269	putative Zn2+ binding site [ion binding]; other site
1125630000270	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
1125630000271	Transposase; Region: HTH_Tnp_1; cl17663
1125630000272	Integrase core domain; Region: rve; pfam00665
1125630000273	multiple promoter invertase; Provisional; Region: mpi; PRK13413
1125630000274	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1125630000275	catalytic residues [active]
1125630000276	catalytic nucleophile [active]
1125630000277	Presynaptic Site I dimer interface [polypeptide binding]; other site
1125630000278	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1125630000279	Synaptic Flat tetramer interface [polypeptide binding]; other site
1125630000280	Synaptic Site I dimer interface [polypeptide binding]; other site
1125630000281	DNA binding site [nucleotide binding]
1125630000282	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393
1125630000283	beta-lactamase TEM; Provisional; Region: PRK15442
1125630000284	Ribosomal RNA methyltransferase (FmrO); Region: FmrO; pfam07091
1125630000285	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
1125630000286	chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777
1125630000287	Putative transposase; Region: Y2_Tnp; pfam04986
1125630000288	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630000289	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
1125630000290	dimerization interface [polypeptide binding]; other site
1125630000291	substrate binding pocket [chemical binding]; other site
1125630000292	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630000293	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1125630000294	putative substrate translocation pore; other site
1125630000295	tetracycline repressor protein TetR; Provisional; Region: PRK13756
1125630000296	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1125630000297	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
1125630000298	Protein of unknown function (DUF3363); Region: DUF3363; pfam11843
1125630000299	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
1125630000300	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630000301	putative substrate translocation pore; other site
1125630000302	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
1125630000303	Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294
1125630000304	substrate binding pocket [chemical binding]; other site
1125630000305	Protein of unknown function (DUF3363); Region: DUF3363; pfam11843
1125630000306	Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893
1125630000307	aminoglycoside resistance protein; Provisional; Region: PRK13746
1125630000308	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
1125630000309	active site
1125630000310	NTP binding site [chemical binding]; other site
1125630000311	metal binding triad [ion binding]; metal-binding site
1125630000312	antibiotic binding site [chemical binding]; other site
1125630000313	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
1125630000314	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1125630000315	folate binding site [chemical binding]; other site
1125630000316	NADP+ binding site [chemical binding]; other site
1125630000317	integrase/recombinase; Provisional; Region: PRK15417
1125630000318	IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193
1125630000319	Int/Topo IB signature motif; other site
1125630000320	valyl-tRNA synthetase-like protein; Provisional; Region: PTZ00419
1125630000321	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
1125630000322	Transposase; Region: HTH_Tnp_1; cl17663
1125630000323	Integrase core domain; Region: rve; pfam00665
1125630000324	Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522
1125630000325	AAA domain; Region: AAA_18; pfam13238
1125630000326	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1125630000327	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
1125630000328	Transposase domain (DUF772); Region: DUF772; pfam05598
1125630000329	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1125630000330	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1125630000331	beta-lactamase TEM; Provisional; Region: PRK15442
1125630000332	Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; pfam04655
1125630000333	Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150
1125630000334	Phosphotransferase enzyme family; Region: APH; pfam01636
1125630000335	active site
1125630000336	ATP binding site [chemical binding]; other site
1125630000337	antibiotic binding site [chemical binding]; other site
1125630000338	Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294
1125630000339	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1125630000340	substrate binding pocket [chemical binding]; other site
1125630000341	dimer interface [polypeptide binding]; other site
1125630000342	inhibitor binding site; inhibition site
1125630000343	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1125630000344	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1125630000345	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1125630000346	P-loop; other site
1125630000347	Magnesium ion binding site [ion binding]; other site
1125630000348	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
1125630000349	ParB-like nuclease domain; Region: ParB; smart00470
1125630000350	KorB domain; Region: KorB; pfam08535
1125630000351	Winged helix-turn helix; Region: HTH_43; cl11547
1125630000352	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
1125630000353	putative transposase OrfB; Reviewed; Region: PHA02517
1125630000354	HTH-like domain; Region: HTH_21; pfam13276
1125630000355	Integrase core domain; Region: rve; pfam00665
1125630000356	Integrase core domain; Region: rve_3; pfam13683
1125630000357	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1125630000358	Transposase; Region: HTH_Tnp_1; cl17663
1125630000359	Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; pfam08273
1125630000360	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
1125630000361	active site
1125630000362	metal binding site [ion binding]; metal-binding site
1125630000363	interdomain interaction site; other site
1125630000364	organizer of macrodomain of Terminus of chromosome; Region: MatP; cl11476
1125630000365	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
1125630000366	RHS Repeat; Region: RHS_repeat; pfam05593
1125630000367	RHS Repeat; Region: RHS_repeat; pfam05593
1125630000368	RHS Repeat; Region: RHS_repeat; pfam05593
1125630000369	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
1125630000370	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
1125630000371	RHS Repeat; Region: RHS_repeat; pfam05593
1125630000372	RHS protein; Region: RHS; pfam03527
1125630000373	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
1125630000374	Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436
1125630000375	Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or...; Region: DSPc; cl00053
1125630000376	active site
1125630000377	catalytic residues [active]
1125630000378	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
1125630000379	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1125630000380	active site
1125630000381	DNA binding site [nucleotide binding]
1125630000382	Int/Topo IB signature motif; other site
1125630000383	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
1125630000384	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1125630000385	active site
1125630000386	catalytic site [active]
1125630000387	substrate binding site [chemical binding]; other site
1125630000388	DNA replication terminus site-binding protein; Provisional; Region: PRK02951
1125630000389	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1125630000390	dimerization interface [polypeptide binding]; other site
1125630000391	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1125630000392	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1125630000393	dimer interface [polypeptide binding]; other site
1125630000394	putative CheW interface [polypeptide binding]; other site
1125630000395	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
1125630000396	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1125630000397	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191
1125630000398	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
1125630000399	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
1125630000400	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1125630000401	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1125630000402	PAS fold; Region: PAS_3; pfam08447
1125630000403	putative active site [active]
1125630000404	heme pocket [chemical binding]; other site
1125630000405	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1125630000406	multiple promoter invertase; Provisional; Region: mpi; PRK13413
1125630000407	catalytic residues [active]
1125630000408	catalytic nucleophile [active]
1125630000409	Presynaptic Site I dimer interface [polypeptide binding]; other site
1125630000410	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1125630000411	Synaptic Flat tetramer interface [polypeptide binding]; other site
1125630000412	Synaptic Site I dimer interface [polypeptide binding]; other site
1125630000413	DNA binding site [nucleotide binding]
1125630000414	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569
1125630000415	DNA-binding interface [nucleotide binding]; DNA binding site
1125630000416	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
1125630000417	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
1125630000418	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
1125630000419	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
1125630000420	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1125630000421	Part of AAA domain; Region: AAA_19; pfam13245
1125630000422	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402
1125630000423	F plasmid transfer operon protein; Region: TraF; pfam13728
1125630000424	Conjugative relaxosome accessory transposon protein; Region: TraH; pfam06122
1125630000425	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
1125630000426	Winged helix-turn-helix DNA-binding; Region: HTH_35; cl17423
1125630000427	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1125630000428	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1125630000429	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1125630000430	Flagellar transcriptional activator (FlhC); Region: FlhC; cl05036
1125630000431	Domain in histone-like proteins of HNS family; Region: HNS; cl19571
1125630000432	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
1125630000433	Mg binding site [ion binding]; other site
1125630000434	nucleotide binding site [chemical binding]; other site
1125630000435	putative protofilament interface [polypeptide binding]; other site
1125630000436	MobA/MobL family; Region: MobA_MobL; pfam03389
1125630000437	Replicase family; Region: Replicase; pfam03090
1125630000438	Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708
1125630000439	Homeodomain-like domain; Region: HTH_23; pfam13384
1125630000440	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
1125630000441	DNA binding site [nucleotide binding]
1125630000442	sequence specific DNA binding site [nucleotide binding]; other site
1125630000443	putative cAMP binding site [chemical binding]; other site
1125630000444	FMN-binding protein MioC; Provisional; Region: PRK09004
1125630000445	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
1125630000446	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1125630000447	putative DNA binding site [nucleotide binding]; other site
1125630000448	putative Zn2+ binding site [ion binding]; other site
1125630000449	AsnC family; Region: AsnC_trans_reg; pfam01037
1125630000450	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
1125630000451	dimer interface [polypeptide binding]; other site
1125630000452	active site
1125630000453	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2425
1125630000454	VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462
1125630000455	metal ion-dependent adhesion site (MIDAS); other site
1125630000456	regulatory ATPase RavA; Provisional; Region: PRK13531
1125630000457	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1125630000458	Walker A motif; other site
1125630000459	ATP binding site [chemical binding]; other site
1125630000460	Walker B motif; other site
1125630000461	arginine finger; other site
1125630000462	Protein of unknown function (DUF3763); Region: DUF3763; pfam12592
1125630000463	potassium transport protein Kup; Provisional; Region: trkD; PRK10745
1125630000464	D-ribose pyranase; Provisional; Region: PRK11797
1125630000465	D-ribose transporter ATP binding protein; Provisional; Region: PRK10762
1125630000466	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1125630000467	Walker A/P-loop; other site
1125630000468	ATP binding site [chemical binding]; other site
1125630000469	Q-loop/lid; other site
1125630000470	ABC transporter signature motif; other site
1125630000471	Walker B; other site
1125630000472	D-loop; other site
1125630000473	H-loop/switch region; other site
1125630000474	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1125630000475	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1125630000476	TM-ABC transporter signature motif; other site
1125630000477	D-ribose transporter subunit RbsB; Provisional; Region: PRK10653
1125630000478	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
1125630000479	ligand binding site [chemical binding]; other site
1125630000480	dimerization interface [polypeptide binding]; other site
1125630000481	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1125630000482	substrate binding site [chemical binding]; other site
1125630000483	dimer interface [polypeptide binding]; other site
1125630000484	ATP binding site [chemical binding]; other site
1125630000485	transcriptional repressor RbsR; Provisional; Region: PRK10423
1125630000486	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1125630000487	DNA binding site [nucleotide binding]
1125630000488	domain linker motif; other site
1125630000489	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
1125630000490	dimerization interface [polypeptide binding]; other site
1125630000491	ligand binding site [chemical binding]; other site
1125630000492	putative transporter; Provisional; Region: PRK10504
1125630000493	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630000494	putative substrate translocation pore; other site
1125630000495	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1125630000496	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1125630000497	DNA-binding site [nucleotide binding]; DNA binding site
1125630000498	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1125630000499	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
1125630000500	Walker A motif; other site
1125630000501	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
1125630000502	GTP binding site; other site
1125630000503	Protein of unknown function (DUF1040); Region: DUF1040; pfam06288
1125630000504	serine/threonine protein kinase; Provisional; Region: PRK11768
1125630000505	Phosphotransferase enzyme family; Region: APH; pfam01636
1125630000506	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
1125630000507	catalytic residues [active]
1125630000508	hinge region; other site
1125630000509	alpha helical domain; other site
1125630000510	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
1125630000511	putative acyl-acceptor binding pocket; other site
1125630000512	DNA polymerase I; Provisional; Region: PRK05755
1125630000513	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1125630000514	active site
1125630000515	putative 5' ssDNA interaction site; other site
1125630000516	metal binding site 3; metal-binding site
1125630000517	metal binding site 1 [ion binding]; metal-binding site
1125630000518	metal binding site 2 [ion binding]; metal-binding site
1125630000519	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1125630000520	putative DNA binding site [nucleotide binding]; other site
1125630000521	putative metal binding site [ion binding]; other site
1125630000522	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
1125630000523	active site
1125630000524	catalytic site [active]
1125630000525	substrate binding site [chemical binding]; other site
1125630000526	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1125630000527	active site
1125630000528	DNA binding site [nucleotide binding]
1125630000529	catalytic site [active]
1125630000530	Predicted GTPase [General function prediction only]; Region: COG0218
1125630000531	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
1125630000532	G1 box; other site
1125630000533	GTP/Mg2+ binding site [chemical binding]; other site
1125630000534	Switch I region; other site
1125630000535	G2 box; other site
1125630000536	G3 box; other site
1125630000537	Switch II region; other site
1125630000538	G4 box; other site
1125630000539	G5 box; other site
1125630000540	Der GTPase activator; Provisional; Region: PRK05244
1125630000541	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
1125630000542	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1125630000543	FeS/SAM binding site; other site
1125630000544	HemN C-terminal domain; Region: HemN_C; pfam06969
1125630000545	nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923
1125630000546	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1125630000547	active site
1125630000548	phosphorylation site [posttranslational modification]
1125630000549	intermolecular recognition site; other site
1125630000550	dimerization interface [polypeptide binding]; other site
1125630000551	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1125630000552	Walker A motif; other site
1125630000553	ATP binding site [chemical binding]; other site
1125630000554	Walker B motif; other site
1125630000555	arginine finger; other site
1125630000556	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1125630000557	nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073
1125630000558	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1125630000559	putative active site [active]
1125630000560	heme pocket [chemical binding]; other site
1125630000561	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1125630000562	dimer interface [polypeptide binding]; other site
1125630000563	phosphorylation site [posttranslational modification]
1125630000564	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1125630000565	ATP binding site [chemical binding]; other site
1125630000566	Mg2+ binding site [ion binding]; other site
1125630000567	G-X-G motif; other site
1125630000568	glutamine synthetase; Provisional; Region: glnA; PRK09469
1125630000569	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1125630000570	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1125630000571	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
1125630000572	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1125630000573	G1 box; other site
1125630000574	putative GEF interaction site [polypeptide binding]; other site
1125630000575	GTP/Mg2+ binding site [chemical binding]; other site
1125630000576	Switch I region; other site
1125630000577	G2 box; other site
1125630000578	G3 box; other site
1125630000579	Switch II region; other site
1125630000580	G4 box; other site
1125630000581	G5 box; other site
1125630000582	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1125630000583	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1125630000584	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
1125630000585	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
1125630000586	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1125630000587	motif II; other site
1125630000588	hypothetical protein; Reviewed; Region: PRK01637
1125630000589	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
1125630000590	putative active site [active]
1125630000591	dimerization interface [polypeptide binding]; other site
1125630000592	putative tRNAtyr binding site [nucleotide binding]; other site
1125630000593	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1125630000594	Coenzyme A binding pocket [chemical binding]; other site
1125630000595	Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500
1125630000596	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
1125630000597	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1125630000598	Ribbon-helix-helix domain; Region: RHH_3; pfam12651
1125630000599	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
1125630000600	oligomeric interface; other site
1125630000601	putative active site [active]
1125630000602	homodimer interface [polypeptide binding]; other site
1125630000603	formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564
1125630000604	formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639
1125630000605	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
1125630000606	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
1125630000607	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
1125630000608	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1125630000609	molybdopterin cofactor binding site; other site
1125630000610	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
1125630000611	molybdopterin cofactor binding site; other site
1125630000612	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1125630000613	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
1125630000614	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
1125630000615	active site
1125630000616	ADP/pyrophosphate binding site [chemical binding]; other site
1125630000617	dimerization interface [polypeptide binding]; other site
1125630000618	allosteric effector site; other site
1125630000619	fructose-1,6-bisphosphate binding site; other site
1125630000620	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
1125630000621	active site
1125630000622	P-loop; other site
1125630000623	phosphorylation site [posttranslational modification]
1125630000624	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997
1125630000625	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1125630000626	intersubunit interface [polypeptide binding]; other site
1125630000627	active site
1125630000628	zinc binding site [ion binding]; other site
1125630000629	Na+ binding site [ion binding]; other site
1125630000630	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1125630000631	active site
1125630000632	phosphorylation site [posttranslational modification]
1125630000633	AAA domain; Region: AAA_17; pfam13207
1125630000634	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
1125630000635	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
1125630000636	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1125630000637	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1125630000638	non-specific DNA binding site [nucleotide binding]; other site
1125630000639	salt bridge; other site
1125630000640	sequence-specific DNA binding site [nucleotide binding]; other site
1125630000641	Cupin domain; Region: Cupin_2; cl17218
1125630000642	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1125630000643	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1125630000644	DNA binding site [nucleotide binding]
1125630000645	domain linker motif; other site
1125630000646	Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271
1125630000647	ligand binding site [chemical binding]; other site
1125630000648	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
1125630000649	Melibiase; Region: Melibiase; pfam02065
1125630000650	galactoside permease; Reviewed; Region: lacY; PRK09528
1125630000651	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630000652	putative substrate translocation pore; other site
1125630000653	L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625
1125630000654	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
1125630000655	dimer interface [polypeptide binding]; other site
1125630000656	active site
1125630000657	metal binding site [ion binding]; metal-binding site
1125630000658	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1125630000659	TM-ABC transporter signature motif; other site
1125630000660	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1125630000661	TM-ABC transporter signature motif; other site
1125630000662	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1125630000663	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1125630000664	Walker A/P-loop; other site
1125630000665	ATP binding site [chemical binding]; other site
1125630000666	Q-loop/lid; other site
1125630000667	ABC transporter signature motif; other site
1125630000668	Walker B; other site
1125630000669	D-loop; other site
1125630000670	H-loop/switch region; other site
1125630000671	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1125630000672	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
1125630000673	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1125630000674	ligand binding site [chemical binding]; other site
1125630000675	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
1125630000676	intersubunit interface [polypeptide binding]; other site
1125630000677	active site
1125630000678	Zn2+ binding site [ion binding]; other site
1125630000679	L-rhamnose isomerase; Provisional; Region: PRK01076
1125630000680	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
1125630000681	N- and C-terminal domain interface [polypeptide binding]; other site
1125630000682	active site
1125630000683	putative catalytic site [active]
1125630000684	metal binding site [ion binding]; metal-binding site
1125630000685	ATP binding site [chemical binding]; other site
1125630000686	rhamnulokinase; Provisional; Region: rhaB; PRK10640
1125630000687	carbohydrate binding site [chemical binding]; other site
1125630000688	transcriptional activator RhaS; Provisional; Region: PRK13503
1125630000689	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1125630000690	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630000691	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630000692	transcriptional activator RhaR; Provisional; Region: PRK13502
1125630000693	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1125630000694	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630000695	Sugar transport protein; Region: Sugar_transport; cl19288
1125630000696	superoxide dismutase; Provisional; Region: PRK10925
1125630000697	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1125630000698	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1125630000699	6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536
1125630000700	MOSC domain; Region: MOSC; pfam03473
1125630000701	3-alpha domain; Region: 3-alpha; pfam03475
1125630000702	two-component sensor protein; Provisional; Region: cpxA; PRK09470
1125630000703	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1125630000704	dimerization interface [polypeptide binding]; other site
1125630000705	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1125630000706	dimer interface [polypeptide binding]; other site
1125630000707	phosphorylation site [posttranslational modification]
1125630000708	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1125630000709	ATP binding site [chemical binding]; other site
1125630000710	Mg2+ binding site [ion binding]; other site
1125630000711	G-X-G motif; other site
1125630000712	DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955
1125630000713	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1125630000714	active site
1125630000715	intermolecular recognition site; other site
1125630000716	dimerization interface [polypeptide binding]; other site
1125630000717	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1125630000718	DNA binding site [nucleotide binding]
1125630000719	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
1125630000720	dimer interface [polypeptide binding]; other site
1125630000721	ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509
1125630000722	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
1125630000723	active site
1125630000724	ADP/pyrophosphate binding site [chemical binding]; other site
1125630000725	dimerization interface [polypeptide binding]; other site
1125630000726	allosteric effector site; other site
1125630000727	fructose-1,6-bisphosphate binding site; other site
1125630000728	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
1125630000729	1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962
1125630000730	putative active site [active]
1125630000731	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
1125630000732	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1125630000733	Walker A motif; other site
1125630000734	ATP binding site [chemical binding]; other site
1125630000735	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1125630000736	Walker B motif; other site
1125630000737	arginine finger; other site
1125630000738	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1125630000739	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
1125630000740	active site
1125630000741	HslU subunit interaction site [polypeptide binding]; other site
1125630000742	cell division protein FtsN; Provisional; Region: PRK12757
1125630000743	Sporulation related domain; Region: SPOR; pfam05036
1125630000744	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1125630000745	DNA binding site [nucleotide binding]
1125630000746	DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041
1125630000747	domain linker motif; other site
1125630000748	Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284
1125630000749	dimerization interface [polypeptide binding]; other site
1125630000750	ligand binding site [chemical binding]; other site
1125630000751	primosome assembly protein PriA; Validated; Region: PRK05580
1125630000752	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1125630000753	ATP binding site [chemical binding]; other site
1125630000754	putative Mg++ binding site [ion binding]; other site
1125630000755	helicase superfamily c-terminal domain; Region: HELICc; smart00490
1125630000756	Ribosomal protein L31; Region: Ribosomal_L31; cl00377
1125630000757	Met Repressor, MetJ.  MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490
1125630000758	dimerization interface [polypeptide binding]; other site
1125630000759	DNA binding site [nucleotide binding]
1125630000760	corepressor binding sites; other site
1125630000761	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1125630000762	homodimer interface [polypeptide binding]; other site
1125630000763	substrate-cofactor binding pocket; other site
1125630000764	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630000765	catalytic residue [active]
1125630000766	bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466
1125630000767	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
1125630000768	putative catalytic residues [active]
1125630000769	putative nucleotide binding site [chemical binding]; other site
1125630000770	putative aspartate binding site [chemical binding]; other site
1125630000771	ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892
1125630000772	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1125630000773	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1125630000774	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
1125630000775	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1125630000776	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
1125630000777	active site
1125630000778	metal binding site [ion binding]; metal-binding site
1125630000779	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1125630000780	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
1125630000781	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
1125630000782	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630000783	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
1125630000784	dimerization interface [polypeptide binding]; other site
1125630000785	substrate binding pocket [chemical binding]; other site
1125630000786	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
1125630000787	FAD binding site [chemical binding]; other site
1125630000788	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1125630000789	EamA-like transporter family; Region: EamA; pfam00892
1125630000790	EamA-like transporter family; Region: EamA; pfam00892
1125630000791	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
1125630000792	dimer interface [polypeptide binding]; other site
1125630000793	active site
1125630000794	metal binding site [ion binding]; metal-binding site
1125630000795	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
1125630000796	active site
1125630000797	intersubunit interactions; other site
1125630000798	catalytic residue [active]
1125630000799	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1125630000800	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630000801	zinc/cadmium-binding protein; Provisional; Region: PRK10306
1125630000802	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
1125630000803	acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892
1125630000804	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
1125630000805	metal binding site [ion binding]; metal-binding site
1125630000806	putative dimer interface [polypeptide binding]; other site
1125630000807	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
1125630000808	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118
1125630000809	Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774
1125630000810	AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249
1125630000811	nucleotide binding site [chemical binding]; other site
1125630000812	N-acetyl-L-glutamate binding site [chemical binding]; other site
1125630000813	argininosuccinate lyase; Provisional; Region: PRK04833
1125630000814	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1125630000815	active sites [active]
1125630000816	tetramer interface [polypeptide binding]; other site
1125630000817	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
1125630000818	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630000819	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
1125630000820	dimerization interface [polypeptide binding]; other site
1125630000821	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
1125630000822	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1125630000823	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
1125630000824	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
1125630000825	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1125630000826	hypothetical protein; Provisional; Region: PRK11056
1125630000827	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
1125630000828	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1125630000829	S-adenosylmethionine binding site [chemical binding]; other site
1125630000830	vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641
1125630000831	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1125630000832	N-terminal plug; other site
1125630000833	ligand-binding site [chemical binding]; other site
1125630000834	glutamate racemase; Provisional; Region: PRK00865
1125630000835	transcriptional regulator HdfR; Provisional; Region: PRK03601
1125630000836	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630000837	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1125630000838	hypothetical protein; Provisional; Region: PRK11027
1125630000839	putative ATP-dependent protease; Provisional; Region: PRK09862
1125630000840	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1125630000841	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1125630000842	Walker A motif; other site
1125630000843	ATP binding site [chemical binding]; other site
1125630000844	Walker B motif; other site
1125630000845	arginine finger; other site
1125630000846	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
1125630000847	acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978
1125630000848	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1125630000849	PYR/PP interface [polypeptide binding]; other site
1125630000850	dimer interface [polypeptide binding]; other site
1125630000851	TPP binding site [chemical binding]; other site
1125630000852	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1125630000853	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1125630000854	TPP-binding site [chemical binding]; other site
1125630000855	dimer interface [polypeptide binding]; other site
1125630000856	acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152
1125630000857	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1125630000858	homodimer interface [polypeptide binding]; other site
1125630000859	substrate-cofactor binding pocket; other site
1125630000860	catalytic residue [active]
1125630000861	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
1125630000862	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1125630000863	threonine dehydratase; Reviewed; Region: PRK09224
1125630000864	tetramer interface [polypeptide binding]; other site
1125630000865	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630000866	catalytic residue [active]
1125630000867	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
1125630000868	putative Ile/Val binding site [chemical binding]; other site
1125630000869	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
1125630000870	putative Ile/Val binding site [chemical binding]; other site
1125630000871	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630000872	DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716
1125630000873	The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430
1125630000874	putative dimerization interface [polypeptide binding]; other site
1125630000875	ketol-acid reductoisomerase; Validated; Region: PRK05225
1125630000876	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
1125630000877	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1125630000878	peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441
1125630000879	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
1125630000880	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
1125630000881	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
1125630000882	ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919
1125630000883	Part of AAA domain; Region: AAA_19; pfam13245
1125630000884	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
1125630000885	Protein of unknown function (DUF554); Region: DUF554; pfam04474
1125630000886	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1125630000887	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630000888	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630000889	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
1125630000890	substrate binding pocket [chemical binding]; other site
1125630000891	dimerization interface [polypeptide binding]; other site
1125630000892	guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031
1125630000893	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1125630000894	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
1125630000895	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1125630000896	ATP binding site [chemical binding]; other site
1125630000897	Mg++ binding site [ion binding]; other site
1125630000898	motif III; other site
1125630000899	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1125630000900	nucleotide binding region [chemical binding]; other site
1125630000901	ATP-binding site [chemical binding]; other site
1125630000902	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1125630000903	catalytic residues [active]
1125630000904	transcription termination factor Rho; Provisional; Region: rho; PRK09376
1125630000905	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
1125630000906	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
1125630000907	RNA binding site [nucleotide binding]; other site
1125630000908	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
1125630000909	multimer interface [polypeptide binding]; other site
1125630000910	Walker A motif; other site
1125630000911	ATP binding site [chemical binding]; other site
1125630000912	Walker B motif; other site
1125630000913	undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380
1125630000914	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
1125630000915	Mg++ binding site [ion binding]; other site
1125630000916	putative catalytic motif [active]
1125630000917	substrate binding site [chemical binding]; other site
1125630000918	lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638
1125630000919	Chain length determinant protein; Region: Wzz; pfam02706
1125630000920	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
1125630000921	UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
1125630000922	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
1125630000923	homodimer interface [polypeptide binding]; other site
1125630000924	active site
1125630000925	UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064
1125630000926	UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721
1125630000927	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1125630000928	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1125630000929	dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217
1125630000930	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1125630000931	NAD binding site [chemical binding]; other site
1125630000932	substrate binding site [chemical binding]; other site
1125630000933	homodimer interface [polypeptide binding]; other site
1125630000934	active site
1125630000935	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
1125630000936	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
1125630000937	substrate binding site; other site
1125630000938	tetramer interface; other site
1125630000939	TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975
1125630000940	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1125630000941	inhibitor-cofactor binding pocket; inhibition site
1125630000942	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630000943	catalytic residue [active]
1125630000944	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1125630000945	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125
1125630000946	4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429
1125630000947	putative common antigen polymerase; Provisional; Region: PRK02975
1125630000948	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
1125630000949	putative transport protein YifK; Provisional; Region: PRK10746
1125630000950	putative protoheme IX biogenesis protein; Provisional; Region: PRK10747
1125630000951	HemY protein N-terminus; Region: HemY_N; pfam07219
1125630000952	Tetratricopeptide repeat; Region: TPR_2; pfam07719
1125630000953	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
1125630000954	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1125630000955	active site
1125630000956	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
1125630000957	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
1125630000958	domain interfaces; other site
1125630000959	active site
1125630000960	Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072
1125630000961	Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633
1125630000962	Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295
1125630000963	Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503
1125630000964	putative iron binding site [ion binding]; other site
1125630000965	Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567
1125630000966	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
1125630000967	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1125630000968	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1125630000969	hypothetical protein; Provisional; Region: PRK10963
1125630000970	Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973
1125630000971	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
1125630000972	active site
1125630000973	Int/Topo IB signature motif; other site
1125630000974	flavin mononucleotide phosphatase; Provisional; Region: PRK10748
1125630000975	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
1125630000976	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1125630000977	motif II; other site
1125630000978	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
1125630000979	Part of AAA domain; Region: AAA_19; pfam13245
1125630000980	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
1125630000981	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
1125630000982	Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835
1125630000983	Cl binding site [ion binding]; other site
1125630000984	oligomer interface [polypeptide binding]; other site
1125630000985	putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430
1125630000986	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
1125630000987	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1125630000988	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
1125630000989	CoenzymeA binding site [chemical binding]; other site
1125630000990	subunit interaction site [polypeptide binding]; other site
1125630000991	PHB binding site; other site
1125630000992	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541
1125630000993	dimerization interface [polypeptide binding]; other site
1125630000994	substrate binding site [chemical binding]; other site
1125630000995	active site
1125630000996	calcium binding site [ion binding]; other site
1125630000997	ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057
1125630000998	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1125630000999	ATP binding site [chemical binding]; other site
1125630001000	putative Mg++ binding site [ion binding]; other site
1125630001001	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1125630001002	nucleotide binding region [chemical binding]; other site
1125630001003	ATP-binding site [chemical binding]; other site
1125630001004	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
1125630001005	Helicase and RNase D C-terminal; Region: HRDC; smart00341
1125630001006	threonine efflux system; Provisional; Region: PRK10229
1125630001007	hypothetical protein; Provisional; Region: PRK09956
1125630001008	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
1125630001009	homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520
1125630001010	lysophospholipase L2; Provisional; Region: PRK10749
1125630001011	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1125630001012	putative hydrolase; Provisional; Region: PRK10976
1125630001013	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1125630001014	active site
1125630001015	motif I; other site
1125630001016	motif II; other site
1125630001017	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
1125630001018	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1125630001019	EamA-like transporter family; Region: EamA; pfam00892
1125630001020	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
1125630001021	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
1125630001022	THF binding site; other site
1125630001023	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1125630001024	substrate binding site [chemical binding]; other site
1125630001025	THF binding site; other site
1125630001026	zinc-binding site [ion binding]; other site
1125630001027	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
1125630001028	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
1125630001029	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
1125630001030	uridine phosphorylase; Provisional; Region: PRK11178
1125630001031	DNA recombination protein RmuC; Provisional; Region: PRK10361
1125630001032	RmuC family; Region: RmuC; pfam02646
1125630001033	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
1125630001034	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1125630001035	S-adenosylmethionine binding site [chemical binding]; other site
1125630001036	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
1125630001037	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
1125630001038	putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750
1125630001039	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
1125630001040	twin arginine translocase protein A; Provisional; Region: tatA; PRK03554
1125630001041	sec-independent translocase; Provisional; Region: PRK01770
1125630001042	sec-independent translocase; Provisional; Region: tatB; PRK00404
1125630001043	twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921
1125630001044	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1125630001045	active site
1125630001046	transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014
1125630001047	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892
1125630001048	KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354
1125630001049	3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922
1125630001050	FMN reductase; Validated; Region: fre; PRK08051
1125630001051	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
1125630001052	FAD binding pocket [chemical binding]; other site
1125630001053	FAD binding motif [chemical binding]; other site
1125630001054	phosphate binding motif [ion binding]; other site
1125630001055	beta-alpha-beta structure motif; other site
1125630001056	NAD binding pocket [chemical binding]; other site
1125630001057	3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947
1125630001058	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1125630001059	dimer interface [polypeptide binding]; other site
1125630001060	active site
1125630001061	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
1125630001062	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1125630001063	substrate binding site [chemical binding]; other site
1125630001064	oxyanion hole (OAH) forming residues; other site
1125630001065	trimer interface [polypeptide binding]; other site
1125630001066	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1125630001067	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1125630001068	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1125630001069	proline dipeptidase; Provisional; Region: PRK13607
1125630001070	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
1125630001071	active site
1125630001072	hypothetical protein; Provisional; Region: PRK11568
1125630001073	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
1125630001074	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
1125630001075	potassium transporter; Provisional; Region: PRK10750
1125630001076	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1125630001077	protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104
1125630001078	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
1125630001079	FAD binding domain; Region: FAD_binding_4; pfam01565
1125630001080	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1125630001081	Biotin operon repressor [Transcription]; Region: BirA; COG1654
1125630001082	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
1125630001083	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
1125630001084	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
1125630001085	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
1125630001086	ATP-binding site [chemical binding]; other site
1125630001087	CoA-binding site [chemical binding]; other site
1125630001088	Mg2+-binding site [ion binding]; other site
1125630001089	elongation factor Tu; Reviewed; Region: PRK00049
1125630001090	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1125630001091	G1 box; other site
1125630001092	GEF interaction site [polypeptide binding]; other site
1125630001093	GTP/Mg2+ binding site [chemical binding]; other site
1125630001094	Switch I region; other site
1125630001095	G2 box; other site
1125630001096	G3 box; other site
1125630001097	Switch II region; other site
1125630001098	G4 box; other site
1125630001099	G5 box; other site
1125630001100	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1125630001101	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1125630001102	Antibiotic Binding Site [chemical binding]; other site
1125630001103	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
1125630001104	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1125630001105	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1125630001106	putative homodimer interface [polypeptide binding]; other site
1125630001107	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1125630001108	heterodimer interface [polypeptide binding]; other site
1125630001109	homodimer interface [polypeptide binding]; other site
1125630001110	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1125630001111	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1125630001112	23S rRNA interface [nucleotide binding]; other site
1125630001113	L7/L12 interface [polypeptide binding]; other site
1125630001114	putative thiostrepton binding site; other site
1125630001115	L25 interface [polypeptide binding]; other site
1125630001116	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1125630001117	mRNA/rRNA interface [nucleotide binding]; other site
1125630001118	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1125630001119	23S rRNA interface [nucleotide binding]; other site
1125630001120	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1125630001121	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1125630001122	core dimer interface [polypeptide binding]; other site
1125630001123	peripheral dimer interface [polypeptide binding]; other site
1125630001124	L10 interface [polypeptide binding]; other site
1125630001125	L11 interface [polypeptide binding]; other site
1125630001126	putative EF-Tu interaction site [polypeptide binding]; other site
1125630001127	putative EF-G interaction site [polypeptide binding]; other site
1125630001128	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
1125630001129	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1125630001130	RPB12 interaction site [polypeptide binding]; other site
1125630001131	RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl19478
1125630001132	RPB1 interaction site [polypeptide binding]; other site
1125630001133	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
1125630001134	RPB10 interaction site [polypeptide binding]; other site
1125630001135	RPB11 interaction site [polypeptide binding]; other site
1125630001136	RPB3 interaction site [polypeptide binding]; other site
1125630001137	Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609
1125630001138	beta and beta' interface [polypeptide binding]; other site
1125630001139	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
1125630001140	beta' and sigma factor interface [polypeptide binding]; other site
1125630001141	Zn-binding [ion binding]; other site
1125630001142	active site region [active]
1125630001143	catalytic site [active]
1125630001144	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1125630001145	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
1125630001146	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1125630001147	G-loop; other site
1125630001148	DNA binding site [nucleotide binding]
1125630001149	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489
1125630001150	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
1125630001151	methionine cluster; other site
1125630001152	active site
1125630001153	phosphorylation site [posttranslational modification]
1125630001154	metal binding site [ion binding]; metal-binding site
1125630001155	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
1125630001156	Cache domain; Region: Cache_1; pfam02743
1125630001157	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1125630001158	metal binding site [ion binding]; metal-binding site
1125630001159	active site
1125630001160	I-site; other site
1125630001161	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
1125630001162	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1125630001163	FeS/SAM binding site; other site
1125630001164	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
1125630001165	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
1125630001166	ThiS interaction site; other site
1125630001167	putative active site [active]
1125630001168	tetramer interface [polypeptide binding]; other site
1125630001169	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
1125630001170	thiS-thiF/thiG interaction site; other site
1125630001171	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1125630001172	thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356
1125630001173	ATP binding site [chemical binding]; other site
1125630001174	substrate interface [chemical binding]; other site
1125630001175	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1125630001176	thiamine phosphate binding site [chemical binding]; other site
1125630001177	active site
1125630001178	pyrophosphate binding site [ion binding]; other site
1125630001179	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
1125630001180	ThiC-associated domain; Region: ThiC-associated; pfam13667
1125630001181	ThiC family; Region: ThiC; pfam01964
1125630001182	anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718
1125630001183	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
1125630001184	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
1125630001185	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
1125630001186	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
1125630001187	putative NADH binding site [chemical binding]; other site
1125630001188	putative active site [active]
1125630001189	nudix motif; other site
1125630001190	putative metal binding site [ion binding]; other site
1125630001191	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
1125630001192	substrate binding site [chemical binding]; other site
1125630001193	active site
1125630001194	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
1125630001195	Active_site [active]
1125630001196	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068
1125630001197	histone-like DNA-binding protein HU; Region: HU; cd13831
1125630001198	dimer interface [polypeptide binding]; other site
1125630001199	DNA binding site [nucleotide binding]
1125630001200	Protein of unknown function (DUF1481); Region: DUF1481; pfam07356
1125630001201	zinc resistance protein; Provisional; Region: zraP; PRK11546
1125630001202	dimer interface [polypeptide binding]; other site
1125630001203	sensor protein ZraS; Provisional; Region: PRK10364
1125630001204	Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827
1125630001205	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1125630001206	dimer interface [polypeptide binding]; other site
1125630001207	phosphorylation site [posttranslational modification]
1125630001208	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1125630001209	ATP binding site [chemical binding]; other site
1125630001210	Mg2+ binding site [ion binding]; other site
1125630001211	G-X-G motif; other site
1125630001212	transcriptional regulatory protein ZraR; Provisional; Region: PRK10365
1125630001213	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1125630001214	active site
1125630001215	phosphorylation site [posttranslational modification]
1125630001216	intermolecular recognition site; other site
1125630001217	dimerization interface [polypeptide binding]; other site
1125630001218	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1125630001219	Walker A motif; other site
1125630001220	ATP binding site [chemical binding]; other site
1125630001221	Walker B motif; other site
1125630001222	arginine finger; other site
1125630001223	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1125630001224	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
1125630001225	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1125630001226	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
1125630001227	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1125630001228	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
1125630001229	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1125630001230	purine monophosphate binding site [chemical binding]; other site
1125630001231	dimer interface [polypeptide binding]; other site
1125630001232	putative catalytic residues [active]
1125630001233	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
1125630001234	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1125630001235	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1125630001236	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1125630001237	Coenzyme A binding pocket [chemical binding]; other site
1125630001238	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
1125630001239	proposed active site lysine [active]
1125630001240	conserved cys residue [active]
1125630001241	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
1125630001242	active site
1125630001243	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1125630001244	tetramer interface [polypeptide binding]; other site
1125630001245	active site
1125630001246	Mg2+/Mn2+ binding site [ion binding]; other site
1125630001247	Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579
1125630001248	transcriptional repressor IclR; Provisional; Region: PRK11569
1125630001249	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1125630001250	Bacterial transcriptional regulator; Region: IclR; pfam01614
1125630001251	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
1125630001252	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
1125630001253	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
1125630001254	substrate binding pocket [chemical binding]; other site
1125630001255	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
1125630001256	B12 binding site [chemical binding]; other site
1125630001257	cobalt ligand [ion binding]; other site
1125630001258	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
1125630001259	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
1125630001260	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
1125630001261	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
1125630001262	shikimate 5-dehydrogenase; Reviewed; Region: PRK12550
1125630001263	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1125630001264	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1125630001265	shikimate binding site; other site
1125630001266	NAD(P) binding site [chemical binding]; other site
1125630001267	L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238
1125630001268	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1125630001269	putative NAD(P) binding site [chemical binding]; other site
1125630001270	catalytic Zn binding site [ion binding]; other site
1125630001271	PTS system, mannose/fructose/sorbose family, IID component; Region: EIID-AGA; TIGR00828
1125630001272	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
1125630001273	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
1125630001274	active site
1125630001275	phosphorylation site [posttranslational modification]
1125630001276	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1125630001277	active pocket/dimerization site; other site
1125630001278	active site
1125630001279	phosphorylation site [posttranslational modification]
1125630001280	sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171
1125630001281	classical (c) SDRs; Region: SDR_c; cd05233
1125630001282	NAD(P) binding site [chemical binding]; other site
1125630001283	active site
1125630001284	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1125630001285	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1125630001286	putative DNA binding site [nucleotide binding]; other site
1125630001287	putative Zn2+ binding site [ion binding]; other site
1125630001288	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1125630001289	23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475
1125630001290	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1125630001291	RNA binding surface [nucleotide binding]; other site
1125630001292	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
1125630001293	probable active site [active]
1125630001294	hypothetical protein; Provisional; Region: PRK10515
1125630001295	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
1125630001296	aspartate kinase III; Validated; Region: PRK09084
1125630001297	AAK_AKiii-LysC-EC: Amino Acid Kinase Superfamily (AAK), AKiii-LysC-EC: this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKIII. AKIII is a monofunctional class enzyme (LysC) found in some...; Region: AAK_AKiii-LysC-EC; cd04258
1125630001298	nucleotide binding site [chemical binding]; other site
1125630001299	putative catalytic residues [active]
1125630001300	aspartate binding site [chemical binding]; other site
1125630001301	ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932
1125630001302	lysine allosteric regulatory site; other site
1125630001303	dimer interface [polypeptide binding]; other site
1125630001304	ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917
1125630001305	dimer interface [polypeptide binding]; other site
1125630001306	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
1125630001307	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1125630001308	active site
1125630001309	dimer interface [polypeptide binding]; other site
1125630001310	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1125630001311	dimer interface [polypeptide binding]; other site
1125630001312	active site
1125630001313	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
1125630001314	putative trimer interface [polypeptide binding]; other site
1125630001315	putative active site [active]
1125630001316	putative substrate binding site [chemical binding]; other site
1125630001317	putative CoA binding site [chemical binding]; other site
1125630001318	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1125630001319	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1125630001320	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1125630001321	homotrimer interaction site [polypeptide binding]; other site
1125630001322	putative active site [active]
1125630001323	potential frameshift: common BLAST hit: gi|375258435|ref|YP_005017605.1| putative transmembrane protein
1125630001324	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
1125630001325	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
1125630001326	L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681
1125630001327	phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833
1125630001328	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1125630001329	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630001330	dimer interface [polypeptide binding]; other site
1125630001331	conserved gate region; other site
1125630001332	putative PBP binding loops; other site
1125630001333	ABC-ATPase subunit interface; other site
1125630001334	maltose transporter membrane protein; Provisional; Region: malF; PRK10999
1125630001335	Maltose transport system permease protein MalF P2 domain; Region: MalF_P2; pfam14785
1125630001336	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630001337	dimer interface [polypeptide binding]; other site
1125630001338	conserved gate region; other site
1125630001339	putative PBP binding loops; other site
1125630001340	ABC-ATPase subunit interface; other site
1125630001341	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
1125630001342	maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474
1125630001343	maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000
1125630001344	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1125630001345	Walker A/P-loop; other site
1125630001346	ATP binding site [chemical binding]; other site
1125630001347	Q-loop/lid; other site
1125630001348	ABC transporter signature motif; other site
1125630001349	Walker B; other site
1125630001350	D-loop; other site
1125630001351	H-loop/switch region; other site
1125630001352	TOBE domain; Region: TOBE_2; pfam08402
1125630001353	maltoporin; Provisional; Region: lamB; PRK09360
1125630001354	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
1125630001355	trimer interface; other site
1125630001356	sugar binding site [chemical binding]; other site
1125630001357	maltose regulon periplasmic protein; Provisional; Region: PRK10564
1125630001358	chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655
1125630001359	4-Hydroxybenzoate polyprenyltransferase; Region: PT_UbiA_COQ2; cd13959
1125630001360	putative active site [active]
1125630001361	Glycerol-3-phosphate O-acyltransferase [Lipid metabolism]; Region: PlsB; COG2937
1125630001362	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
1125630001363	putative acyl-acceptor binding pocket; other site
1125630001364	Integral membrane diacylglycerol kinase; Region: DAGK_IM; cd14264
1125630001365	putative active site [active]
1125630001366	trimer interface [polypeptide binding]; other site
1125630001367	putative active site [active]
1125630001368	Zn binding site [ion binding]; other site
1125630001369	LexA repressor; Validated; Region: PRK00215
1125630001370	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
1125630001371	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1125630001372	Catalytic site [active]
1125630001373	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
1125630001374	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
1125630001375	hypothetical protein; Provisional; Region: PRK10428
1125630001376	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1125630001377	metal binding site 2 [ion binding]; metal-binding site
1125630001378	putative DNA binding helix; other site
1125630001379	metal binding site 1 [ion binding]; metal-binding site
1125630001380	dimer interface [polypeptide binding]; other site
1125630001381	structural Zn2+ binding site [ion binding]; other site
1125630001382	Cupin domain; Region: Cupin_2; cl17218
1125630001383	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1125630001384	Dihydrouridine synthase (Dus); Region: Dus; pfam01207
1125630001385	FMN binding site [chemical binding]; other site
1125630001386	active site
1125630001387	catalytic residues [active]
1125630001388	substrate binding site [chemical binding]; other site
1125630001389	phage shock protein G; Reviewed; Region: pspG; PRK09459
1125630001390	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
1125630001391	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
1125630001392	NADP binding site [chemical binding]; other site
1125630001393	dimer interface [polypeptide binding]; other site
1125630001394	replicative DNA helicase; Provisional; Region: PRK08006
1125630001395	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1125630001396	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1125630001397	Walker A motif; other site
1125630001398	ATP binding site [chemical binding]; other site
1125630001399	Walker B motif; other site
1125630001400	DNA binding loops [nucleotide binding]
1125630001401	alanine racemase; Reviewed; Region: alr; PRK00053
1125630001402	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
1125630001403	active site
1125630001404	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1125630001405	substrate binding site [chemical binding]; other site
1125630001406	catalytic residues [active]
1125630001407	dimer interface [polypeptide binding]; other site
1125630001408	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
1125630001409	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1125630001410	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630001411	homodimer interface [polypeptide binding]; other site
1125630001412	catalytic residue [active]
1125630001413	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1125630001414	active site
1125630001415	motif I; other site
1125630001416	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
1125630001417	motif II; other site
1125630001418	Uncharacterized conserved protein [Function unknown]; Region: COG0432
1125630001419	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
1125630001420	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1125630001421	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1125630001422	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1125630001423	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1125630001424	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1125630001425	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1125630001426	dimer interface [polypeptide binding]; other site
1125630001427	ssDNA binding site [nucleotide binding]; other site
1125630001428	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1125630001429	putative single-stranded DNA-binding protein; Region: PHA01740
1125630001430	Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein [Cell envelope biogenesis, outer membrane]; Region: COG4623
1125630001431	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1125630001432	substrate binding pocket [chemical binding]; other site
1125630001433	membrane-bound complex binding site; other site
1125630001434	hinge residues; other site
1125630001435	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1125630001436	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1125630001437	catalytic residue [active]
1125630001438	outer membrane receptor FepA; Provisional; Region: PRK13524
1125630001439	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1125630001440	N-terminal plug; other site
1125630001441	ligand-binding site [chemical binding]; other site
1125630001442	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630001443	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1125630001444	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630001445	Tannase and feruloyl esterase; Region: Tannase; pfam07519
1125630001446	outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067
1125630001447	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1125630001448	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1125630001449	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1125630001450	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1125630001451	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1125630001452	Surface antigen; Region: Bac_surface_Ag; pfam01103
1125630001453	anti-adapter protein IraM; Provisional; Region: PRK09919
1125630001454	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1125630001455	active site
1125630001456	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1125630001457	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1125630001458	DNA binding site [nucleotide binding]
1125630001459	domain linker motif; other site
1125630001460	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278
1125630001461	putative dimerization interface [polypeptide binding]; other site
1125630001462	putative ligand binding site [chemical binding]; other site
1125630001463	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
1125630001464	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1125630001465	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1125630001466	Walker A/P-loop; other site
1125630001467	ATP binding site [chemical binding]; other site
1125630001468	Q-loop/lid; other site
1125630001469	ABC transporter signature motif; other site
1125630001470	Walker B; other site
1125630001471	D-loop; other site
1125630001472	H-loop/switch region; other site
1125630001473	TOBE domain; Region: TOBE_2; pfam08402
1125630001474	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1125630001475	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1125630001476	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1125630001477	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630001478	dimer interface [polypeptide binding]; other site
1125630001479	conserved gate region; other site
1125630001480	putative PBP binding loops; other site
1125630001481	ABC-ATPase subunit interface; other site
1125630001482	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630001483	dimer interface [polypeptide binding]; other site
1125630001484	conserved gate region; other site
1125630001485	putative PBP binding loops; other site
1125630001486	ABC-ATPase subunit interface; other site
1125630001487	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
1125630001488	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
1125630001489	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1125630001490	DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219
1125630001491	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630001492	redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002
1125630001493	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
1125630001494	DNA binding residues [nucleotide binding]
1125630001495	dimer interface [polypeptide binding]; other site
1125630001496	[2Fe-2S] cluster binding site [ion binding]; other site
1125630001497	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1125630001498	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
1125630001499	putative C-terminal domain interface [polypeptide binding]; other site
1125630001500	putative GSH binding site (G-site) [chemical binding]; other site
1125630001501	putative dimer interface [polypeptide binding]; other site
1125630001502	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
1125630001503	putative N-terminal domain interface [polypeptide binding]; other site
1125630001504	putative dimer interface [polypeptide binding]; other site
1125630001505	putative substrate binding pocket (H-site) [chemical binding]; other site
1125630001506	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1125630001507	Sulfate transporter family; Region: Sulfate_transp; cl19250
1125630001508	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1125630001509	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
1125630001510	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630001511	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630001512	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
1125630001513	putative dimerization interface [polypeptide binding]; other site
1125630001514	LrgA family; Region: LrgA; cl00608
1125630001515	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
1125630001516	Fimbrial protein; Region: Fimbrial; cl01416
1125630001517	fimbrial assembly chaperone SthB; Provisional; Region: PRK15295
1125630001518	Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345
1125630001519	Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753
1125630001520	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
1125630001521	PapC N-terminal domain; Region: PapC_N; pfam13954
1125630001522	Outer membrane usher protein; Region: Usher; pfam00577
1125630001523	PapC C-terminal domain; Region: PapC_C; pfam13953
1125630001524	Fimbrial protein; Region: Fimbrial; cl01416
1125630001525	putative major fimbrial protein SthE; Provisional; Region: PRK15292
1125630001526	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
1125630001527	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
1125630001528	Na binding site [ion binding]; other site
1125630001529	Predicted membrane protein [Function unknown]; Region: COG3162
1125630001530	acetyl-CoA synthetase; Provisional; Region: PRK00174
1125630001531	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
1125630001532	active site
1125630001533	CoA binding site [chemical binding]; other site
1125630001534	acyl-activating enzyme (AAE) consensus motif; other site
1125630001535	AMP binding site [chemical binding]; other site
1125630001536	acetate binding site [chemical binding]; other site
1125630001537	glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283
1125630001538	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1125630001539	potential frameshift: common BLAST hit: gi|238892571|ref|YP_002917305.1| formate dehydrogenase-H
1125630001540	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1125630001541	molybdopterin cofactor binding site; other site
1125630001542	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790
1125630001543	molybdopterin cofactor binding site; other site
1125630001544	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1125630001545	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1125630001546	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1125630001547	active site
1125630001548	phosphorylation site [posttranslational modification]
1125630001549	intermolecular recognition site; other site
1125630001550	dimerization interface [polypeptide binding]; other site
1125630001551	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1125630001552	DNA binding site [nucleotide binding]
1125630001553	Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459
1125630001554	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
1125630001555	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1125630001556	substrate binding site [chemical binding]; other site
1125630001557	ATP binding site [chemical binding]; other site
1125630001558	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1125630001559	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321
1125630001560	putative ligand binding site [chemical binding]; other site
1125630001561	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1125630001562	TM-ABC transporter signature motif; other site
1125630001563	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1125630001564	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1125630001565	Walker A/P-loop; other site
1125630001566	ATP binding site [chemical binding]; other site
1125630001567	Q-loop/lid; other site
1125630001568	ABC transporter signature motif; other site
1125630001569	Walker B; other site
1125630001570	D-loop; other site
1125630001571	H-loop/switch region; other site
1125630001572	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1125630001573	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1125630001574	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1125630001575	dimerization interface [polypeptide binding]; other site
1125630001576	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1125630001577	dimer interface [polypeptide binding]; other site
1125630001578	phosphorylation site [posttranslational modification]
1125630001579	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1125630001580	ATP binding site [chemical binding]; other site
1125630001581	Mg2+ binding site [ion binding]; other site
1125630001582	G-X-G motif; other site
1125630001583	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1125630001584	active site
1125630001585	phosphorylation site [posttranslational modification]
1125630001586	intermolecular recognition site; other site
1125630001587	carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244
1125630001588	ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078
1125630001589	active site
1125630001590	phosphonate metabolism protein PhnM; Provisional; Region: PRK15446
1125630001591	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1125630001592	PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306
1125630001593	active site
1125630001594	ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778
1125630001595	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1125630001596	Walker A/P-loop; other site
1125630001597	ATP binding site [chemical binding]; other site
1125630001598	Q-loop/lid; other site
1125630001599	ABC transporter signature motif; other site
1125630001600	Walker B; other site
1125630001601	D-loop; other site
1125630001602	H-loop/switch region; other site
1125630001603	phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701
1125630001604	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1125630001605	Walker A/P-loop; other site
1125630001606	ATP binding site [chemical binding]; other site
1125630001607	Q-loop/lid; other site
1125630001608	ABC transporter signature motif; other site
1125630001609	Walker B; other site
1125630001610	D-loop; other site
1125630001611	H-loop/switch region; other site
1125630001612	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1125630001613	Phosphonate metabolizm protein PhnJ; Region: PhnJ; pfam06007
1125630001614	Bacterial phosphonate metabolizm protein (PhnI); Region: PhnI; pfam05861
1125630001615	carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147
1125630001616	Phosphonate metabolizm protein PhnG; Region: PhnG; pfam06754
1125630001617	phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079
1125630001618	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1125630001619	DNA-binding site [nucleotide binding]; DNA binding site
1125630001620	UTRA domain; Region: UTRA; pfam07702
1125630001621	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1125630001622	dimer interface [polypeptide binding]; other site
1125630001623	PhnA protein; Region: PhnA; pfam03831
1125630001624	proline/glycine betaine transporter; Provisional; Region: PRK10642
1125630001625	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630001626	putative substrate translocation pore; other site
1125630001627	Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946
1125630001628	DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371
1125630001629	Cupin domain; Region: Cupin_2; cl17218
1125630001630	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630001631	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630001632	alpha-galactosidase; Provisional; Region: PRK15076
1125630001633	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
1125630001634	NAD binding site [chemical binding]; other site
1125630001635	sugar binding site [chemical binding]; other site
1125630001636	divalent metal binding site [ion binding]; other site
1125630001637	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
1125630001638	dimer interface [polypeptide binding]; other site
1125630001639	melibiose:sodium symporter; Provisional; Region: PRK10429
1125630001640	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
1125630001641	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
1125630001642	Mg binding site [ion binding]; other site
1125630001643	nucleotide binding site [chemical binding]; other site
1125630001644	putative protofilament interface [polypeptide binding]; other site
1125630001645	Plasmid stability protein; Region: Plasmid_stab_B; pfam10784
1125630001646	putative transposase OrfB; Reviewed; Region: PHA02517
1125630001647	HTH-like domain; Region: HTH_21; pfam13276
1125630001648	Integrase core domain; Region: rve; pfam00665
1125630001649	Integrase core domain; Region: rve_2; pfam13333
1125630001650	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1125630001651	Helix-turn-helix domain; Region: HTH_28; pfam13518
1125630001652	Helix-turn-helix domain; Region: HTH_28; pfam13518
1125630001653	chaperone-modulator protein CbpM; Provisional; Region: PRK10265
1125630001654	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
1125630001655	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1125630001656	HSP70 interaction site [polypeptide binding]; other site
1125630001657	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
1125630001658	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1125630001659	substrate binding site [polypeptide binding]; other site
1125630001660	dimer interface [polypeptide binding]; other site
1125630001661	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
1125630001662	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
1125630001663	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
1125630001664	catalytic residues [active]
1125630001665	hemin storage system protein; Provisional; Region: hmsS; PRK14584
1125630001666	N-glycosyltransferase; Provisional; Region: PRK11204
1125630001667	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
1125630001668	DXD motif; other site
1125630001669	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1125630001670	outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582
1125630001671	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
1125630001672	Hypothetical glycosyl hydrolase family 13; Region: GHL13; pfam14883
1125630001673	outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049
1125630001674	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
1125630001675	DNA binding residues [nucleotide binding]
1125630001676	dimerization interface [polypeptide binding]; other site
1125630001677	PerC transcriptional activator; Region: PerC; pfam06069
1125630001678	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
1125630001679	putative transcriptional regulator; Provisional; Region: PRK11640
1125630001680	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
1125630001681	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
1125630001682	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1125630001683	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
1125630001684	DsbD alpha interface [polypeptide binding]; other site
1125630001685	catalytic residues [active]
1125630001686	divalent-cation tolerance protein CutA; Provisional; Region: PRK10645
1125630001687	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
1125630001688	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
1125630001689	Aspartase; Region: Aspartase; cd01357
1125630001690	active sites [active]
1125630001691	tetramer interface [polypeptide binding]; other site
1125630001692	Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030
1125630001693	putative transporter; Provisional; Region: PRK11021
1125630001694	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1125630001695	oligomerisation interface [polypeptide binding]; other site
1125630001696	mobile loop; other site
1125630001697	roof hairpin; other site
1125630001698	chaperonin GroEL; Reviewed; Region: groEL; PRK12850
1125630001699	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1125630001700	ring oligomerisation interface [polypeptide binding]; other site
1125630001701	ATP/Mg binding site [chemical binding]; other site
1125630001702	stacking interactions; other site
1125630001703	hinge regions; other site
1125630001704	Domain of unknown function (DUF4156); Region: DUF4156; pfam13698
1125630001705	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
1125630001706	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419
1125630001707	putative active site [active]
1125630001708	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1125630001709	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1125630001710	Walker A/P-loop; other site
1125630001711	ATP binding site [chemical binding]; other site
1125630001712	Q-loop/lid; other site
1125630001713	ABC transporter signature motif; other site
1125630001714	Walker B; other site
1125630001715	D-loop; other site
1125630001716	H-loop/switch region; other site
1125630001717	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
1125630001718	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1125630001719	HlyD family secretion protein; Region: HlyD_3; pfam13437
1125630001720	Fimbrial protein; Region: Fimbrial; pfam00419
1125630001721	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
1125630001722	PapC N-terminal domain; Region: PapC_N; pfam13954
1125630001723	Outer membrane usher protein; Region: Usher; pfam00577
1125630001724	PapC C-terminal domain; Region: PapC_C; pfam13953
1125630001725	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
1125630001726	Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345
1125630001727	Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753
1125630001728	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
1125630001729	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
1125630001730	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1125630001731	DNA binding site [nucleotide binding]
1125630001732	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1125630001733	Radical SAM superfamily; Region: Radical_SAM; pfam04055
1125630001734	FeS/SAM binding site; other site
1125630001735	elongation factor P; Validated; Region: PRK00529
1125630001736	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1125630001737	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1125630001738	RNA binding site [nucleotide binding]; other site
1125630001739	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1125630001740	RNA binding site [nucleotide binding]; other site
1125630001741	Entericidin EcnA/B family; Region: Entericidin; cl02322
1125630001742	entericidin B membrane lipoprotein; Provisional; Region: PRK10081
1125630001743	multidrug efflux system protein; Provisional; Region: PRK11431
1125630001744	outer membrane lipoprotein Blc; Provisional; Region: PRK10477
1125630001745	Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547
1125630001746	Iron-sulfur protein interface; other site
1125630001747	proximal quinone binding site [chemical binding]; other site
1125630001748	C-subunit interface; other site
1125630001749	distal quinone binding site; other site
1125630001750	Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C;  QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546
1125630001751	D-subunit interface [polypeptide binding]; other site
1125630001752	Iron-sulfur protein interface; other site
1125630001753	proximal quinone binding site [chemical binding]; other site
1125630001754	distal quinone binding site [chemical binding]; other site
1125630001755	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385
1125630001756	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1125630001757	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
1125630001758	fumarate reductase flavoprotein subunit; Validated; Region: PRK09231
1125630001759	L-aspartate oxidase; Provisional; Region: PRK06175
1125630001760	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1125630001761	poxB regulator PoxA; Provisional; Region: PRK09350
1125630001762	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1125630001763	motif 1; other site
1125630001764	dimer interface [polypeptide binding]; other site
1125630001765	active site
1125630001766	motif 2; other site
1125630001767	motif 3; other site
1125630001768	inner membrane transporter YjeM; Provisional; Region: PRK15238
1125630001769	putative mechanosensitive channel protein; Provisional; Region: PRK10929
1125630001770	Protein-interacting V-domain of mammalian Alix and related domains; Region: V_Alix_like; cl14654
1125630001771	putative YPXnL-motif binding site; other site
1125630001772	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
1125630001773	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1125630001774	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
1125630001775	GTPase RsgA; Reviewed; Region: PRK12288
1125630001776	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1125630001777	RNA binding site [nucleotide binding]; other site
1125630001778	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1125630001779	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1125630001780	GTP/Mg2+ binding site [chemical binding]; other site
1125630001781	G4 box; other site
1125630001782	G5 box; other site
1125630001783	G1 box; other site
1125630001784	Switch I region; other site
1125630001785	G2 box; other site
1125630001786	G3 box; other site
1125630001787	Switch II region; other site
1125630001788	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
1125630001789	catalytic site [active]
1125630001790	putative active site [active]
1125630001791	putative substrate binding site [chemical binding]; other site
1125630001792	dimer interface [polypeptide binding]; other site
1125630001793	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1125630001794	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1125630001795	substrate binding pocket [chemical binding]; other site
1125630001796	membrane-bound complex binding site; other site
1125630001797	hinge residues; other site
1125630001798	epoxyqueuosine reductase; Region: TIGR00276
1125630001799	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
1125630001800	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
1125630001801	putative carbohydrate kinase; Provisional; Region: PRK10565
1125630001802	Uncharacterized conserved protein [Function unknown]; Region: COG0062
1125630001803	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1125630001804	putative substrate binding site [chemical binding]; other site
1125630001805	putative ATP binding site [chemical binding]; other site
1125630001806	ADP-binding protein; Provisional; Region: PRK10646
1125630001807	N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431
1125630001808	AMIN domain; Region: AMIN; pfam11741
1125630001809	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1125630001810	active site
1125630001811	metal binding site [ion binding]; metal-binding site
1125630001812	potential frameshift: common BLAST hit: gi|288937531|ref|YP_003441590.1| DNA mismatch repair protein MutL
1125630001813	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1125630001814	Mg2+ binding site [ion binding]; other site
1125630001815	G-X-G motif; other site
1125630001816	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
1125630001817	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
1125630001818	ATP binding site [chemical binding]; other site
1125630001819	MutL C terminal dimerization domain; Region: MutL_C; pfam08676
1125630001820	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
1125630001821	bacterial Hfq-like; Region: Hfq; cd01716
1125630001822	hexamer interface [polypeptide binding]; other site
1125630001823	Sm1 motif; other site
1125630001824	RNA binding site [nucleotide binding]; other site
1125630001825	Sm2 motif; other site
1125630001826	GTPase HflX; Provisional; Region: PRK11058
1125630001827	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1125630001828	HflX GTPase family; Region: HflX; cd01878
1125630001829	G1 box; other site
1125630001830	GTP/Mg2+ binding site [chemical binding]; other site
1125630001831	Switch I region; other site
1125630001832	G2 box; other site
1125630001833	G3 box; other site
1125630001834	Switch II region; other site
1125630001835	G4 box; other site
1125630001836	G5 box; other site
1125630001837	FtsH protease regulator HflK; Provisional; Region: PRK10930
1125630001838	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
1125630001839	High frequency of lysogenization K (HflK) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflK; cd03404
1125630001840	HflC protein; Region: hflC; TIGR01932
1125630001841	High frequency of lysogenization C (HflC) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflC; cd03405
1125630001842	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242
1125630001843	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1125630001844	GDP-binding site [chemical binding]; other site
1125630001845	ACT binding site; other site
1125630001846	IMP binding site; other site
1125630001847	transcriptional repressor NsrR; Provisional; Region: PRK11014
1125630001848	Rrf2 family protein; Region: rrf2_super; TIGR00738
1125630001849	exoribonuclease R; Provisional; Region: PRK11642
1125630001850	Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461
1125630001851	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
1125630001852	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
1125630001853	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
1125630001854	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
1125630001855	RNA binding site [nucleotide binding]; other site
1125630001856	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
1125630001857	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
1125630001858	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1125630001859	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
1125630001860	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1125630001861	active site
1125630001862	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
1125630001863	putative biofilm stress and motility protein A; Provisional; Region: PRK14864
1125630001864	esterase; Provisional; Region: PRK10566
1125630001865	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1125630001866	transcriptional repressor UlaR; Provisional; Region: PRK13509
1125630001867	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1125630001868	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1125630001869	putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709
1125630001870	Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037
1125630001871	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
1125630001872	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1125630001873	active site
1125630001874	phosphorylation site [posttranslational modification]
1125630001875	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
1125630001876	active site
1125630001877	dimer interface [polypeptide binding]; other site
1125630001878	magnesium binding site [ion binding]; other site
1125630001879	L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209
1125630001880	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
1125630001881	AP (apurinic/apyrimidinic) site pocket; other site
1125630001882	DNA interaction; other site
1125630001883	Metal-binding active site; metal-binding site
1125630001884	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
1125630001885	intersubunit interface [polypeptide binding]; other site
1125630001886	active site
1125630001887	Zn2+ binding site [ion binding]; other site
1125630001888	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630001889	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1125630001890	putative substrate translocation pore; other site
1125630001891	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
1125630001892	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1125630001893	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
1125630001894	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1125630001895	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1125630001896	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1125630001897	Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525
1125630001898	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
1125630001899	peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570
1125630001900	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
1125630001901	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1125630001902	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
1125630001903	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
1125630001904	iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992
1125630001905	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
1125630001906	Hemerythrin-like domain; Region: Hr-like; cd12108
1125630001907	Fe binding site [ion binding]; other site
1125630001908	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1125630001909	EamA-like transporter family; Region: EamA; pfam00892
1125630001910	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1125630001911	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1125630001912	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630001913	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630001914	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1125630001915	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
1125630001916	NADP binding site [chemical binding]; other site
1125630001917	Predicted transcriptional regulators [Transcription]; Region: COG1733
1125630001918	dimerization interface [polypeptide binding]; other site
1125630001919	putative DNA binding site [nucleotide binding]; other site
1125630001920	putative Zn2+ binding site [ion binding]; other site
1125630001921	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
1125630001922	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
1125630001923	active site
1125630001924	metal binding site [ion binding]; metal-binding site
1125630001925	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1125630001926	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
1125630001927	active site
1125630001928	Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; cl17398
1125630001929	Protein of unknown function (DUF1107); Region: DUF1107; pfam06526
1125630001930	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1125630001931	Domain of unknown function DUF21; Region: DUF21; pfam01595
1125630001932	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1125630001933	Transporter associated domain; Region: CorC_HlyC; smart01091
1125630001934	methionine sulfoxide reductase A; Provisional; Region: PRK00058
1125630001935	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
1125630001936	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1125630001937	Surface antigen; Region: Bac_surface_Ag; pfam01103
1125630001938	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
1125630001939	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1125630001940	Family of unknown function (DUF490); Region: DUF490; pfam04357
1125630001941	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
1125630001942	dimerization interface [polypeptide binding]; other site
1125630001943	putative active site pocket [active]
1125630001944	putative catalytic residue [active]
1125630001945	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
1125630001946	dimer interface [polypeptide binding]; other site
1125630001947	substrate binding site [chemical binding]; other site
1125630001948	metal binding sites [ion binding]; metal-binding site
1125630001949	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1125630001950	Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309
1125630001951	putative ligand binding site [chemical binding]; other site
1125630001952	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1125630001953	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1125630001954	Walker A/P-loop; other site
1125630001955	ATP binding site [chemical binding]; other site
1125630001956	Q-loop/lid; other site
1125630001957	ABC transporter signature motif; other site
1125630001958	Walker B; other site
1125630001959	D-loop; other site
1125630001960	H-loop/switch region; other site
1125630001961	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1125630001962	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1125630001963	TM-ABC transporter signature motif; other site
1125630001964	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1125630001965	TM-ABC transporter signature motif; other site
1125630001966	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
1125630001967	AMP binding site [chemical binding]; other site
1125630001968	metal binding site [ion binding]; metal-binding site
1125630001969	active site
1125630001970	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
1125630001971	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1125630001972	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1125630001973	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1125630001974	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1125630001975	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1125630001976	Coenzyme A binding pocket [chemical binding]; other site
1125630001977	Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023
1125630001978	active site
1125630001979	catalytic residues [active]
1125630001980	hypothetical protein; Provisional; Region: PRK05255
1125630001981	peptidase PmbA; Provisional; Region: PRK11040
1125630001982	Cytochrome b562; Region: Cytochrom_B562; cl01546
1125630001983	PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582
1125630001984	Glycine-rich SFCGS; Region: Gly_rich_SFCGS; pfam14272
1125630001985	Domain of unknown function (DUF4312); Region: DUF4312; cl11917
1125630001986	conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580
1125630001987	Domain of unknown function (DUF4310); Region: DUF4310; pfam14187
1125630001988	dihydroorotase; Provisional; Region: PRK09237
1125630001989	Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307
1125630001990	active site
1125630001991	uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437
1125630001992	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1125630001993	catalytic residue [active]
1125630001994	conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581
1125630001995	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
1125630001996	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1125630001997	HTH domain; Region: HTH_11; pfam08279
1125630001998	Mga helix-turn-helix domain; Region: Mga; pfam05043
1125630001999	PRD domain; Region: PRD; pfam00874
1125630002000	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1125630002001	active site
1125630002002	P-loop; other site
1125630002003	phosphorylation site [posttranslational modification]
1125630002004	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1125630002005	active site
1125630002006	phosphorylation site [posttranslational modification]
1125630002007	bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235
1125630002008	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
1125630002009	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491
1125630002010	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1125630002011	FeS/SAM binding site; other site
1125630002012	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
1125630002013	ATP cone domain; Region: ATP-cone; pfam03477
1125630002014	Class III ribonucleotide reductase; Region: RNR_III; cd01675
1125630002015	effector binding site; other site
1125630002016	active site
1125630002017	Zn binding site [ion binding]; other site
1125630002018	glycine loop; other site
1125630002019	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1125630002020	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1125630002021	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
1125630002022	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
1125630002023	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
1125630002024	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
1125630002025	NAD binding site [chemical binding]; other site
1125630002026	sugar binding site [chemical binding]; other site
1125630002027	divalent metal binding site [ion binding]; other site
1125630002028	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1125630002029	dimer interface [polypeptide binding]; other site
1125630002030	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295
1125630002031	trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933
1125630002032	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1125630002033	Ca binding site [ion binding]; other site
1125630002034	active site
1125630002035	catalytic site [active]
1125630002036	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
1125630002037	PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007
1125630002038	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1125630002039	active site turn [active]
1125630002040	phosphorylation site [posttranslational modification]
1125630002041	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1125630002042	trehalose repressor; Provisional; Region: treR; PRK09492
1125630002043	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1125630002044	DNA binding site [nucleotide binding]
1125630002045	domain linker motif; other site
1125630002046	Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542
1125630002047	dimerization interface [polypeptide binding]; other site
1125630002048	ligand binding site [chemical binding]; other site
1125630002049	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
1125630002050	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
1125630002051	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1125630002052	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1125630002053	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1125630002054	motif II; other site
1125630002055	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1125630002056	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1125630002057	homotrimer interaction site [polypeptide binding]; other site
1125630002058	putative active site [active]
1125630002059	aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893
1125630002060	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
1125630002061	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
1125630002062	aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670
1125630002063	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1125630002064	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1125630002065	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
1125630002066	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
1125630002067	A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710
1125630002068	putative active site [active]
1125630002069	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1125630002070	dimer interface [polypeptide binding]; other site
1125630002071	active site
1125630002072	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1125630002073	substrate binding site [chemical binding]; other site
1125630002074	ATP binding site [chemical binding]; other site
1125630002075	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
1125630002076	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1125630002077	active site
1125630002078	Predicted membrane protein [Function unknown]; Region: COG1288
1125630002079	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1125630002080	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1125630002081	DNA-binding site [nucleotide binding]; DNA binding site
1125630002082	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1125630002083	ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515
1125630002084	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1125630002085	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1125630002086	RNase E inhibitor protein; Provisional; Region: PRK11191
1125630002087	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
1125630002088	dinuclear metal binding motif [ion binding]; other site
1125630002089	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1125630002090	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1125630002091	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1125630002092	active site
1125630002093	HIGH motif; other site
1125630002094	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1125630002095	KMSKS motif; other site
1125630002096	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1125630002097	tRNA binding surface [nucleotide binding]; other site
1125630002098	anticodon binding site; other site
1125630002099	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1125630002100	DNA polymerase III subunit chi; Validated; Region: PRK05728
1125630002101	multifunctional aminopeptidase A; Provisional; Region: PRK00913
1125630002102	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1125630002103	interface (dimer of trimers) [polypeptide binding]; other site
1125630002104	Substrate-binding/catalytic site; other site
1125630002105	Zn-binding sites [ion binding]; other site
1125630002106	lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120
1125630002107	lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071
1125630002108	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
1125630002109	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1125630002110	Walker A motif; other site
1125630002111	ATP binding site [chemical binding]; other site
1125630002112	Walker B motif; other site
1125630002113	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
1125630002114	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1125630002115	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
1125630002116	tetrameric interface [polypeptide binding]; other site
1125630002117	NAD binding site [chemical binding]; other site
1125630002118	catalytic residues [active]
1125630002119	Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718
1125630002120	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1125630002121	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1125630002122	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1125630002123	putative active site [active]
1125630002124	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1125630002125	substrate binding site [chemical binding]; other site
1125630002126	ATP binding site [chemical binding]; other site
1125630002127	Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863
1125630002128	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
1125630002129	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1125630002130	PYR/PP interface [polypeptide binding]; other site
1125630002131	dimer interface [polypeptide binding]; other site
1125630002132	TPP binding site [chemical binding]; other site
1125630002133	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1125630002134	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
1125630002135	TPP-binding site; other site
1125630002136	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1125630002137	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1125630002138	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1125630002139	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1125630002140	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1125630002141	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1125630002142	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1125630002143	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1125630002144	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1125630002145	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1125630002146	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1125630002147	Walker A/P-loop; other site
1125630002148	ATP binding site [chemical binding]; other site
1125630002149	Q-loop/lid; other site
1125630002150	ABC transporter signature motif; other site
1125630002151	Walker B; other site
1125630002152	D-loop; other site
1125630002153	H-loop/switch region; other site
1125630002154	TOBE domain; Region: TOBE_2; pfam08402
1125630002155	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
1125630002156	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
1125630002157	active site
1125630002158	metal binding site [ion binding]; metal-binding site
1125630002159	hexamer interface [polypeptide binding]; other site
1125630002160	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1125630002161	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630002162	dimer interface [polypeptide binding]; other site
1125630002163	conserved gate region; other site
1125630002164	putative PBP binding loops; other site
1125630002165	ABC-ATPase subunit interface; other site
1125630002166	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630002167	dimer interface [polypeptide binding]; other site
1125630002168	conserved gate region; other site
1125630002169	putative PBP binding loops; other site
1125630002170	ABC-ATPase subunit interface; other site
1125630002171	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1125630002172	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
1125630002173	putative NAD(P) binding site [chemical binding]; other site
1125630002174	putative substrate binding site [chemical binding]; other site
1125630002175	catalytic Zn binding site [ion binding]; other site
1125630002176	structural Zn binding site [ion binding]; other site
1125630002177	dimer interface [polypeptide binding]; other site
1125630002178	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1125630002179	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1125630002180	Sulfate transporter family; Region: Sulfate_transp; cl19250
1125630002181	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
1125630002182	active site clefts [active]
1125630002183	zinc binding site [ion binding]; other site
1125630002184	dimer interface [polypeptide binding]; other site
1125630002185	integrase; Provisional; Region: PRK09692
1125630002186	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
1125630002187	active site
1125630002188	Int/Topo IB signature motif; other site
1125630002189	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
1125630002190	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1125630002191	Phage polarity suppression protein (Psu); Region: Psu; pfam07455
1125630002192	Ogr/Delta-like zinc finger; Region: Ogr_Delta; cl19592
1125630002193	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
1125630002194	Oxygenase, catalyzing oxidative methylation of damaged DNA; Region: Oxygenase-NA; cl17606
1125630002195	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643
1125630002196	Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778
1125630002197	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
1125630002198	active site
1125630002199	metal binding site [ion binding]; metal-binding site
1125630002200	interdomain interaction site; other site
1125630002201	D5 N terminal like; Region: D5_N; smart00885
1125630002202	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
1125630002203	Transposase; Region: HTH_Tnp_1; pfam01527
1125630002204	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1125630002205	Integrase core domain; Region: rve; pfam00665
1125630002206	Integrase core domain; Region: rve_3; pfam13683
1125630002207	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1125630002208	putative active site [active]
1125630002209	catalytic site [active]
1125630002210	Protein of unknown function (DUF796); Region: DUF796; cl01226
1125630002211	conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744
1125630002212	Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440
1125630002213	HNH endonuclease; Region: HNH_2; pfam13391
1125630002214	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1125630002215	active site
1125630002216	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
1125630002217	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
1125630002218	inhibitor binding site; inhibition site
1125630002219	active site
1125630002220	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
1125630002221	putative symporter YagG; Provisional; Region: PRK09669; cl15392
1125630002222	xylose isomerase; Provisional; Region: PRK05474
1125630002223	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1125630002224	maltoporin; Provisional; Region: lamB; PRK09360
1125630002225	Uncharacterized conserved protein [Function unknown]; Region: COG1683
1125630002226	Uncharacterized conserved protein [Function unknown]; Region: COG3272
1125630002227	Protein of unknown function (DUF3833); Region: DUF3833; pfam12915
1125630002228	Protein of unknown function (DUF2878); Region: DUF2878; pfam11086
1125630002229	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
1125630002230	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1125630002231	S-adenosylmethionine binding site [chemical binding]; other site
1125630002232	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
1125630002233	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
1125630002234	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1125630002235	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1125630002236	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1125630002237	short chain dehydrogenase; Region: adh_short; pfam00106
1125630002238	NAD(P) binding site [chemical binding]; other site
1125630002239	active site
1125630002240	SnoaL-like domain; Region: SnoaL_2; pfam12680
1125630002241	transcriptional regulator MirA; Provisional; Region: PRK15043
1125630002242	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
1125630002243	DNA binding residues [nucleotide binding]
1125630002244	outer membrane lipoprotein Blc; Provisional; Region: PRK10477
1125630002245	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
1125630002246	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
1125630002247	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
1125630002248	HlyD family secretion protein; Region: HlyD_3; pfam13437
1125630002249	periplasmic copper-binding protein; Provisional; Region: PRK09838
1125630002250	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
1125630002251	Outer membrane efflux protein; Region: OEP; pfam02321
1125630002252	Outer membrane efflux protein; Region: OEP; pfam02321
1125630002253	DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836
1125630002254	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1125630002255	active site
1125630002256	phosphorylation site [posttranslational modification]
1125630002257	intermolecular recognition site; other site
1125630002258	dimerization interface [polypeptide binding]; other site
1125630002259	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1125630002260	DNA binding site [nucleotide binding]
1125630002261	sensor kinase CusS; Provisional; Region: PRK09835
1125630002262	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1125630002263	dimerization interface [polypeptide binding]; other site
1125630002264	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1125630002265	dimer interface [polypeptide binding]; other site
1125630002266	phosphorylation site [posttranslational modification]
1125630002267	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1125630002268	ATP binding site [chemical binding]; other site
1125630002269	Mg2+ binding site [ion binding]; other site
1125630002270	G-X-G motif; other site
1125630002271	Protein of unknown function (DUF1778); Region: DUF1778; pfam08681
1125630002272	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1125630002273	Uncharacterized conserved protein [Function unknown]; Region: COG2850
1125630002274	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580
1125630002275	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1125630002276	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1125630002277	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1125630002278	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1125630002279	Walker A/P-loop; other site
1125630002280	ATP binding site [chemical binding]; other site
1125630002281	Q-loop/lid; other site
1125630002282	ABC transporter signature motif; other site
1125630002283	Walker B; other site
1125630002284	D-loop; other site
1125630002285	H-loop/switch region; other site
1125630002286	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1125630002287	Walker A/P-loop; other site
1125630002288	ATP binding site [chemical binding]; other site
1125630002289	Q-loop/lid; other site
1125630002290	ABC transporter signature motif; other site
1125630002291	Walker B; other site
1125630002292	D-loop; other site
1125630002293	H-loop/switch region; other site
1125630002294	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1125630002295	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
1125630002296	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
1125630002297	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1125630002298	HlyD family secretion protein; Region: HlyD_3; pfam13437
1125630002299	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1125630002300	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1125630002301	active site
1125630002302	HIGH motif; other site
1125630002303	dimer interface [polypeptide binding]; other site
1125630002304	KMSKS motif; other site
1125630002305	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
1125630002306	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1125630002307	ligand binding site [chemical binding]; other site
1125630002308	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1125630002309	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1125630002310	Walker A/P-loop; other site
1125630002311	ATP binding site [chemical binding]; other site
1125630002312	Q-loop/lid; other site
1125630002313	ABC transporter signature motif; other site
1125630002314	Walker B; other site
1125630002315	D-loop; other site
1125630002316	H-loop/switch region; other site
1125630002317	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1125630002318	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1125630002319	TM-ABC transporter signature motif; other site
1125630002320	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1125630002321	TM-ABC transporter signature motif; other site
1125630002322	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
1125630002323	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630002324	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630002325	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1125630002326	dimerization interface [polypeptide binding]; other site
1125630002327	FosA, a Fosfomycin resistance protein, catalyzes the addition of glutathione to the antibiotic fosfomycin, making it inactive; Region: FosA; cd07244
1125630002328	dimer interface [polypeptide binding]; other site
1125630002329	Mn binding site [ion binding]; other site
1125630002330	K binding site [ion binding]; other site
1125630002331	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1125630002332	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1125630002333	DNA-binding site [nucleotide binding]; DNA binding site
1125630002334	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1125630002335	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630002336	homodimer interface [polypeptide binding]; other site
1125630002337	catalytic residue [active]
1125630002338	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
1125630002339	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
1125630002340	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1125630002341	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
1125630002342	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1125630002343	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
1125630002344	Protein of unknown function (DUF2955); Region: DUF2955; pfam11168
1125630002345	Protein of unknown function (DUF3343); Region: DUF3343; pfam11823
1125630002346	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
1125630002347	Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775
1125630002348	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
1125630002349	Uncharacterized conserved protein (DUF2164); Region: DUF2164; cl02278
1125630002350	multidrug efflux system protein MdtM; Provisional; Region: PRK15403
1125630002351	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630002352	putative substrate translocation pore; other site
1125630002353	Predicted membrane protein [Function unknown]; Region: COG2733
1125630002354	Protein of unknown function (DUF445); Region: DUF445; pfam04286
1125630002355	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1125630002356	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1125630002357	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1125630002358	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630002359	hypothetical protein; Provisional; Region: PRK09956
1125630002360	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
1125630002361	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
1125630002362	NAD(P) binding site [chemical binding]; other site
1125630002363	catalytic residues [active]
1125630002364	YfaZ precursor; Region: YfaZ; pfam07437
1125630002365	putative GTP-binding protein YjiA; Provisional; Region: PRK11537
1125630002366	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
1125630002367	P-loop, Walker A motif; other site
1125630002368	Base recognition motif; other site
1125630002369	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1125630002370	Uncharacterized small protein [Function unknown]; Region: COG2879
1125630002371	carbon starvation protein A; Provisional; Region: PRK15015
1125630002372	Carbon starvation protein CstA; Region: CstA; pfam02554
1125630002373	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
1125630002374	4-hydroxyphenylacetate 3-monooxygenase reductase subunit; Provisional; Region: hpaC; PRK15486
1125630002375	4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310
1125630002376	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
1125630002377	4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297
1125630002378	Cupin domain; Region: Cupin_2; pfam07883
1125630002379	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1125630002380	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630002381	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
1125630002382	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630002383	putative substrate translocation pore; other site
1125630002384	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; Region: HpaI; TIGR02311
1125630002385	2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312
1125630002386	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
1125630002387	putative substrate binding pocket [chemical binding]; other site
1125630002388	trimer interface [polypeptide binding]; other site
1125630002389	The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370
1125630002390	putative active site [active]
1125630002391	putative metal binding site [ion binding]; other site
1125630002392	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
1125630002393	NAD binding site [chemical binding]; other site
1125630002394	catalytic residues [active]
1125630002395	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303
1125630002396	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1125630002397	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
1125630002398	homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337
1125630002399	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1125630002400	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
1125630002401	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
1125630002402	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818
1125630002403	dimer interface [polypeptide binding]; other site
1125630002404	active site
1125630002405	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1125630002406	substrate binding site [chemical binding]; other site
1125630002407	catalytic residue [active]
1125630002408	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
1125630002409	D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
1125630002410	active site
1125630002411	putative substrate binding pocket [chemical binding]; other site
1125630002412	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1125630002413	homotrimer interaction site [polypeptide binding]; other site
1125630002414	putative active site [active]
1125630002415	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
1125630002416	Na binding site [ion binding]; other site
1125630002417	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
1125630002418	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
1125630002419	active site
1125630002420	intersubunit interface [polypeptide binding]; other site
1125630002421	catalytic residue [active]
1125630002422	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1125630002423	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1125630002424	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1125630002425	putative active site [active]
1125630002426	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1125630002427	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1125630002428	Coenzyme A binding pocket [chemical binding]; other site
1125630002429	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1125630002430	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1125630002431	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1125630002432	Coenzyme A binding pocket [chemical binding]; other site
1125630002433	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630002434	D-galactonate transporter; Region: 2A0114; TIGR00893
1125630002435	putative substrate translocation pore; other site
1125630002436	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
1125630002437	DNA-binding site [nucleotide binding]; DNA binding site
1125630002438	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1125630002439	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
1125630002440	DNA-binding site [nucleotide binding]; DNA binding site
1125630002441	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1125630002442	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
1125630002443	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1125630002444	putative NAD(P) binding site [chemical binding]; other site
1125630002445	catalytic Zn binding site [ion binding]; other site
1125630002446	structural Zn binding site [ion binding]; other site
1125630002447	altronate oxidoreductase; Provisional; Region: PRK03643
1125630002448	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1125630002449	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1125630002450	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
1125630002451	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1125630002452	Walker A motif; other site
1125630002453	ATP binding site [chemical binding]; other site
1125630002454	Walker B motif; other site
1125630002455	arginine finger; other site
1125630002456	Transcriptional antiterminator [Transcription]; Region: COG3933
1125630002457	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1125630002458	active pocket/dimerization site; other site
1125630002459	active site
1125630002460	phosphorylation site [posttranslational modification]
1125630002461	PRD domain; Region: PRD; pfam00874
1125630002462	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1125630002463	active pocket/dimerization site; other site
1125630002464	active site
1125630002465	phosphorylation site [posttranslational modification]
1125630002466	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
1125630002467	active site
1125630002468	phosphorylation site [posttranslational modification]
1125630002469	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
1125630002470	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
1125630002471	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
1125630002472	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1125630002473	dimer interface [polypeptide binding]; other site
1125630002474	active site
1125630002475	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1125630002476	dimer interface [polypeptide binding]; other site
1125630002477	active site
1125630002478	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
1125630002479	A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710
1125630002480	putative active site [active]
1125630002481	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
1125630002482	hypothetical protein; Provisional; Region: PRK09956
1125630002483	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
1125630002484	Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811
1125630002485	DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is...; Region: DEP; cl02442
1125630002486	phosphoglycerol transferase I; Provisional; Region: PRK03776
1125630002487	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1125630002488	hypothetical protein; Provisional; Region: PRK11667
1125630002489	DNA replication protein DnaC; Validated; Region: PRK07952
1125630002490	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1125630002491	Walker A motif; other site
1125630002492	ATP binding site [chemical binding]; other site
1125630002493	Walker B motif; other site
1125630002494	primosomal protein DnaI; Provisional; Region: PRK02854
1125630002495	hypothetical protein; Provisional; Region: PRK09917
1125630002496	Uncharacterized conserved protein [Function unknown]; Region: COG2966
1125630002497	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
1125630002498	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
1125630002499	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
1125630002500	4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297
1125630002501	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630002502	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1125630002503	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1125630002504	DNA binding residues [nucleotide binding]
1125630002505	dimerization interface [polypeptide binding]; other site
1125630002506	DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475
1125630002507	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1125630002508	DNA binding residues [nucleotide binding]
1125630002509	dimerization interface [polypeptide binding]; other site
1125630002510	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
1125630002511	putative deacylase active site [active]
1125630002512	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1125630002513	ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647
1125630002514	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1125630002515	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
1125630002516	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1125630002517	metal binding site [ion binding]; metal-binding site
1125630002518	active site
1125630002519	I-site; other site
1125630002520	Protein of unknown function (DUF1435); Region: DUF1435; pfam07256
1125630002521	16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489
1125630002522	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
1125630002523	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1125630002524	S-adenosylmethionine binding site [chemical binding]; other site
1125630002525	DNA polymerase III subunit psi; Validated; Region: PRK06856
1125630002526	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1125630002527	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1125630002528	Coenzyme A binding pocket [chemical binding]; other site
1125630002529	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
1125630002530	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1125630002531	motif II; other site
1125630002532	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
1125630002533	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
1125630002534	G1 box; other site
1125630002535	putative GEF interaction site [polypeptide binding]; other site
1125630002536	GTP/Mg2+ binding site [chemical binding]; other site
1125630002537	Switch I region; other site
1125630002538	G2 box; other site
1125630002539	G3 box; other site
1125630002540	Switch II region; other site
1125630002541	G4 box; other site
1125630002542	G5 box; other site
1125630002543	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
1125630002544	Elongation Factor G, domain II; Region: EFG_II; pfam14492
1125630002545	periplasmic protein; Provisional; Region: PRK10568
1125630002546	BON domain; Region: BON; pfam04972
1125630002547	BON domain; Region: BON; pfam04972
1125630002548	Small integral membrane protein [Function unknown]; Region: COG5487; cl17674
1125630002549	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
1125630002550	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
1125630002551	active site
1125630002552	nucleophile elbow; other site
1125630002553	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1125630002554	active site
1125630002555	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1125630002556	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1125630002557	Nucleoside recognition; Region: Gate; pfam07670
1125630002558	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1125630002559	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1125630002560	intersubunit interface [polypeptide binding]; other site
1125630002561	active site
1125630002562	catalytic residue [active]
1125630002563	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
1125630002564	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1125630002565	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1125630002566	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
1125630002567	phosphopentomutase; Provisional; Region: PRK05362
1125630002568	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
1125630002569	lipoate-protein ligase A; Provisional; Region: lplA; PRK03822
1125630002570	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1125630002571	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
1125630002572	hypothetical protein; Provisional; Region: PRK11246
1125630002573	phosphoserine phosphatase; Provisional; Region: serB; PRK11133
1125630002574	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1125630002575	motif II; other site
1125630002576	DNA repair protein RadA; Region: sms; TIGR00416
1125630002577	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
1125630002578	Walker A motif/ATP binding site; other site
1125630002579	ATP binding site [chemical binding]; other site
1125630002580	Walker B motif; other site
1125630002581	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1125630002582	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1125630002583	non-specific DNA binding site [nucleotide binding]; other site
1125630002584	salt bridge; other site
1125630002585	bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099
1125630002586	sequence-specific DNA binding site [nucleotide binding]; other site
1125630002587	Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167
1125630002588	active site
1125630002589	(T/H)XGH motif; other site
1125630002590	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
1125630002591	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
1125630002592	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1125630002593	ABC transporter; Region: ABC_tran_2; pfam12848
1125630002594	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1125630002595	lytic murein transglycosylase; Provisional; Region: PRK11619
1125630002596	Soluble lytic murein transglycosylase L domain; Region: SLT_L; pfam14718
1125630002597	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1125630002598	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1125630002599	catalytic residue [active]
1125630002600	Trp operon repressor; Provisional; Region: PRK01381
1125630002601	inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074
1125630002602	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1125630002603	catalytic core [active]
1125630002604	right oriC-binding transcriptional activator; Provisional; Region: PRK15121
1125630002605	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630002606	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630002607	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
1125630002608	hypothetical protein; Provisional; Region: PRK10756
1125630002609	DNA-binding response regulator CreB; Provisional; Region: PRK11083
1125630002610	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1125630002611	active site
1125630002612	phosphorylation site [posttranslational modification]
1125630002613	intermolecular recognition site; other site
1125630002614	dimerization interface [polypeptide binding]; other site
1125630002615	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1125630002616	DNA binding site [nucleotide binding]
1125630002617	sensory histidine kinase CreC; Provisional; Region: PRK11100
1125630002618	HAMP domain; Region: HAMP; pfam00672
1125630002619	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1125630002620	dimer interface [polypeptide binding]; other site
1125630002621	phosphorylation site [posttranslational modification]
1125630002622	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1125630002623	ATP binding site [chemical binding]; other site
1125630002624	Mg2+ binding site [ion binding]; other site
1125630002625	G-X-G motif; other site
1125630002626	Inner membrane protein CreD; Region: CreD; pfam06123
1125630002627	two-component response regulator; Provisional; Region: PRK11173
1125630002628	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1125630002629	active site
1125630002630	phosphorylation site [posttranslational modification]
1125630002631	intermolecular recognition site; other site
1125630002632	dimerization interface [polypeptide binding]; other site
1125630002633	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1125630002634	DNA binding site [nucleotide binding]
1125630002635	putative RNA methyltransferase; Provisional; Region: PRK10433
1125630002636	RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050
1125630002637	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
1125630002638	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
1125630002639	putative catalytic residues [active]
1125630002640	putative nucleotide binding site [chemical binding]; other site
1125630002641	putative aspartate binding site [chemical binding]; other site
1125630002642	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
1125630002643	dimer interface [polypeptide binding]; other site
1125630002644	putative threonine allosteric regulatory site; other site
1125630002645	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
1125630002646	putative threonine allosteric regulatory site; other site
1125630002647	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1125630002648	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1125630002649	homoserine kinase; Provisional; Region: PRK01212
1125630002650	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1125630002651	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1125630002652	threonine synthase; Validated; Region: PRK09225
1125630002653	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
1125630002654	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1125630002655	catalytic residue [active]
1125630002656	hypothetical protein; Validated; Region: PRK02101
1125630002657	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1125630002658	transaldolase-like protein; Provisional; Region: PTZ00411
1125630002659	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
1125630002660	active site
1125630002661	dimer interface [polypeptide binding]; other site
1125630002662	catalytic residue [active]
1125630002663	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1125630002664	MPT binding site; other site
1125630002665	trimer interface [polypeptide binding]; other site
1125630002666	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630002667	metabolite-proton symporter; Region: 2A0106; TIGR00883
1125630002668	putative substrate translocation pore; other site
1125630002669	hypothetical protein; Provisional; Region: PRK10659
1125630002670	hypothetical protein; Provisional; Region: PRK10236
1125630002671	Domain of unknown function (DUF3944); Region: DUF3944; pfam13099
1125630002672	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735
1125630002673	Protein of unknown function (DUF2541); Region: DUF2541; pfam10807
1125630002674	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1125630002675	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1125630002676	nucleotide binding site [chemical binding]; other site
1125630002677	chaperone protein DnaJ; Provisional; Region: PRK10767
1125630002678	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1125630002679	HSP70 interaction site [polypeptide binding]; other site
1125630002680	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1125630002681	substrate binding site [polypeptide binding]; other site
1125630002682	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1125630002683	Zn binding sites [ion binding]; other site
1125630002684	dimer interface [polypeptide binding]; other site
1125630002685	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561
1125630002686	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
1125630002687	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630002688	The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429
1125630002689	putative dimerization interface [polypeptide binding]; other site
1125630002690	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
1125630002691	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
1125630002692	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1125630002693	active site
1125630002694	Riboflavin kinase; Region: Flavokinase; smart00904
1125630002695	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
1125630002696	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1125630002697	active site
1125630002698	HIGH motif; other site
1125630002699	KMSKS motif; other site
1125630002700	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
1125630002701	tRNA binding surface [nucleotide binding]; other site
1125630002702	anticodon binding site; other site
1125630002703	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1125630002704	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
1125630002705	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
1125630002706	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
1125630002707	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944
1125630002708	Fe-S cluster binding site [ion binding]; other site
1125630002709	substrate binding site [chemical binding]; other site
1125630002710	catalytic site [active]
1125630002711	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
1125630002712	active site
1125630002713	tetramer interface [polypeptide binding]; other site
1125630002714	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630002715	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630002716	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1125630002717	putative effector binding pocket; other site
1125630002718	dimerization interface [polypeptide binding]; other site
1125630002719	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
1125630002720	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
1125630002721	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
1125630002722	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1125630002723	active site
1125630002724	phosphorylation site [posttranslational modification]
1125630002725	intermolecular recognition site; other site
1125630002726	dimerization interface [polypeptide binding]; other site
1125630002727	Transcriptional regulator; Region: CitT; pfam12431
1125630002728	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
1125630002729	Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827
1125630002730	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1125630002731	putative active site [active]
1125630002732	Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689
1125630002733	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1125630002734	ATP binding site [chemical binding]; other site
1125630002735	Mg2+ binding site [ion binding]; other site
1125630002736	G-X-G motif; other site
1125630002737	oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15477
1125630002738	oxaloacetate decarboxylase; Provisional; Region: PRK14040
1125630002739	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
1125630002740	active site
1125630002741	catalytic residues [active]
1125630002742	metal binding site [ion binding]; metal-binding site
1125630002743	homodimer binding site [polypeptide binding]; other site
1125630002744	Conserved carboxylase domain; Region: PYC_OADA; pfam02436
1125630002745	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1125630002746	carboxyltransferase (CT) interaction site; other site
1125630002747	biotinylation site [posttranslational modification]; other site
1125630002748	oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919
1125630002749	Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493
1125630002750	[citrate (pro-3S)-lyase] ligase; Region: cit_ly_ligase; TIGR00124
1125630002751	Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169
1125630002752	putative active site [active]
1125630002753	(T/H)XGH motif; other site
1125630002754	citrate lyase acyl carrier protein; Region: citD; TIGR01608
1125630002755	citrate lyase, beta subunit; Region: citE; TIGR01588
1125630002756	Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051
1125630002757	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
1125630002758	ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768
1125630002759	Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289
1125630002760	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1125630002761	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1125630002762	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1125630002763	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
1125630002764	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1125630002765	catalytic site [active]
1125630002766	subunit interface [polypeptide binding]; other site
1125630002767	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1125630002768	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1125630002769	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1125630002770	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096
1125630002771	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1125630002772	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1125630002773	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1125630002774	IMP binding site; other site
1125630002775	dimer interface [polypeptide binding]; other site
1125630002776	interdomain contacts; other site
1125630002777	partial ornithine binding site; other site
1125630002778	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
1125630002779	glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871
1125630002780	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
1125630002781	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
1125630002782	TrkA-N domain; Region: TrkA_N; pfam02254
1125630002783	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1125630002784	folate binding site [chemical binding]; other site
1125630002785	NADP+ binding site [chemical binding]; other site
1125630002786	bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668
1125630002787	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
1125630002788	active site
1125630002789	metal binding site [ion binding]; metal-binding site
1125630002790	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
1125630002791	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1125630002792	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
1125630002793	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
1125630002794	SurA N-terminal domain; Region: SurA_N; pfam09312
1125630002795	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1125630002796	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1125630002797	LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761
1125630002798	OstA-like protein; Region: OstA; pfam03968
1125630002799	Organic solvent tolerance protein; Region: OstA_C; pfam04453
1125630002800	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
1125630002801	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
1125630002802	putative metal binding site [ion binding]; other site
1125630002803	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1125630002804	HSP70 interaction site [polypeptide binding]; other site
1125630002805	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
1125630002806	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1125630002807	active site
1125630002808	phosphorylation site [posttranslational modification]
1125630002809	intermolecular recognition site; other site
1125630002810	dimerization interface [polypeptide binding]; other site
1125630002811	Transcriptional regulator; Region: CitT; pfam12431
1125630002812	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1125630002813	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
1125630002814	Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827
1125630002815	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1125630002816	putative active site [active]
1125630002817	heme pocket [chemical binding]; other site
1125630002818	Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689
1125630002819	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1125630002820	ATP binding site [chemical binding]; other site
1125630002821	Mg2+ binding site [ion binding]; other site
1125630002822	G-X-G motif; other site
1125630002823	2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390
1125630002824	holo-ACP synthase CitX; Region: citrate_citX; TIGR03124
1125630002825	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1125630002826	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1125630002827	active site
1125630002828	ATP-dependent helicase HepA; Validated; Region: PRK04914
1125630002829	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1125630002830	ATP binding site [chemical binding]; other site
1125630002831	putative Mg++ binding site [ion binding]; other site
1125630002832	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1125630002833	nucleotide binding region [chemical binding]; other site
1125630002834	ATP-binding site [chemical binding]; other site
1125630002835	RNA polymerase recycling family C-terminal; Region: RapA_C; pfam12137
1125630002836	DNA polymerase II; Reviewed; Region: PRK05762
1125630002837	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784
1125630002838	active site
1125630002839	catalytic site [active]
1125630002840	substrate binding site [chemical binding]; other site
1125630002841	DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537
1125630002842	active site
1125630002843	metal-binding site
1125630002844	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
1125630002845	intersubunit interface [polypeptide binding]; other site
1125630002846	active site
1125630002847	Zn2+ binding site [ion binding]; other site
1125630002848	L-arabinose isomerase; Provisional; Region: PRK02929
1125630002849	L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557
1125630002850	putative hexamer (dimer of trimers) interface [polypeptide binding]; other site
1125630002851	trimer interface [polypeptide binding]; other site
1125630002852	putative substrate binding site [chemical binding]; other site
1125630002853	putative metal binding site [ion binding]; other site
1125630002854	ribulokinase; Provisional; Region: PRK04123
1125630002855	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
1125630002856	N- and C-terminal domain interface [polypeptide binding]; other site
1125630002857	active site
1125630002858	MgATP binding site [chemical binding]; other site
1125630002859	catalytic site [active]
1125630002860	metal binding site [ion binding]; metal-binding site
1125630002861	carbohydrate binding site [chemical binding]; other site
1125630002862	homodimer interface [polypeptide binding]; other site
1125630002863	DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572
1125630002864	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1125630002865	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630002866	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630002867	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1125630002868	thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771
1125630002869	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1125630002870	Walker A/P-loop; other site
1125630002871	ATP binding site [chemical binding]; other site
1125630002872	Q-loop/lid; other site
1125630002873	ABC transporter signature motif; other site
1125630002874	Walker B; other site
1125630002875	D-loop; other site
1125630002876	H-loop/switch region; other site
1125630002877	thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433
1125630002878	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630002879	dimer interface [polypeptide binding]; other site
1125630002880	conserved gate region; other site
1125630002881	putative PBP binding loops; other site
1125630002882	ABC-ATPase subunit interface; other site
1125630002883	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630002884	dimer interface [polypeptide binding]; other site
1125630002885	conserved gate region; other site
1125630002886	putative PBP binding loops; other site
1125630002887	ABC-ATPase subunit interface; other site
1125630002888	thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205
1125630002889	transcriptional regulator SgrR; Provisional; Region: PRK13626
1125630002890	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
1125630002891	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
1125630002892	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630002893	sugar efflux transporter; Region: 2A0120; TIGR00899
1125630002894	putative substrate translocation pore; other site
1125630002895	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630002896	D-galactonate transporter; Region: 2A0114; TIGR00893
1125630002897	putative substrate translocation pore; other site
1125630002898	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630002899	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630002900	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
1125630002901	putative dimerization interface [polypeptide binding]; other site
1125630002902	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
1125630002903	active site
1125630002904	catalytic residue [active]
1125630002905	dimer interface [polypeptide binding]; other site
1125630002906	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630002907	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1125630002908	putative substrate translocation pore; other site
1125630002909	shikimate 5-dehydrogenase; Provisional; Region: PRK12548
1125630002910	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1125630002911	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1125630002912	shikimate binding site; other site
1125630002913	NAD(P) binding site [chemical binding]; other site
1125630002914	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
1125630002915	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
1125630002916	active site
1125630002917	FMN binding site [chemical binding]; other site
1125630002918	substrate binding site [chemical binding]; other site
1125630002919	putative catalytic residue [active]
1125630002920	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
1125630002921	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1125630002922	NAD binding site [chemical binding]; other site
1125630002923	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1125630002924	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1125630002925	substrate binding site [chemical binding]; other site
1125630002926	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1125630002927	substrate binding site [chemical binding]; other site
1125630002928	ligand binding site [chemical binding]; other site
1125630002929	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
1125630002930	2-isopropylmalate synthase; Validated; Region: PRK00915
1125630002931	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
1125630002932	active site
1125630002933	catalytic residues [active]
1125630002934	metal binding site [ion binding]; metal-binding site
1125630002935	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
1125630002936	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
1125630002937	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630002938	The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466
1125630002939	putative substrate binding pocket [chemical binding]; other site
1125630002940	putative dimerization interface [polypeptide binding]; other site
1125630002941	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979
1125630002942	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1125630002943	PYR/PP interface [polypeptide binding]; other site
1125630002944	dimer interface [polypeptide binding]; other site
1125630002945	TPP binding site [chemical binding]; other site
1125630002946	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1125630002947	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1125630002948	TPP-binding site [chemical binding]; other site
1125630002949	dimer interface [polypeptide binding]; other site
1125630002950	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
1125630002951	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
1125630002952	putative valine binding site [chemical binding]; other site
1125630002953	dimer interface [polypeptide binding]; other site
1125630002954	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
1125630002955	DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303
1125630002956	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1125630002957	DNA binding site [nucleotide binding]
1125630002958	domain linker motif; other site
1125630002959	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
1125630002960	dimerization interface [polypeptide binding]; other site
1125630002961	ligand binding site [chemical binding]; other site
1125630002962	mraZ protein; Region: TIGR00242
1125630002963	MraZ protein; Region: MraZ; pfam02381
1125630002964	MraZ protein; Region: MraZ; pfam02381
1125630002965	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
1125630002966	Cell division protein FtsL; Region: FtsL; cl11433
1125630002967	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
1125630002968	Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717
1125630002969	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1125630002970	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
1125630002971	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1125630002972	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1125630002973	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1125630002974	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773
1125630002975	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1125630002976	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1125630002977	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1125630002978	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1125630002979	Mg++ binding site [ion binding]; other site
1125630002980	putative catalytic motif [active]
1125630002981	putative substrate binding site [chemical binding]; other site
1125630002982	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806
1125630002983	Protein of unknown function (DUF2453); Region: DUF2453; pfam10507
1125630002984	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1125630002985	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1125630002986	cell division protein FtsW; Provisional; Region: PRK10774
1125630002987	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
1125630002988	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1125630002989	active site
1125630002990	homodimer interface [polypeptide binding]; other site
1125630002991	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1125630002992	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1125630002993	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1125630002994	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1125630002995	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
1125630002996	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1125630002997	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
1125630002998	cell division protein FtsQ; Provisional; Region: PRK10775
1125630002999	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1125630003000	Cell division protein FtsQ; Region: FtsQ; pfam03799
1125630003001	cell division protein FtsA; Reviewed; Region: ftsA; PRK09472
1125630003002	Cell division protein FtsA; Region: FtsA; smart00842
1125630003003	Cell division protein FtsA; Region: FtsA; pfam14450
1125630003004	cell division protein FtsZ; Validated; Region: PRK09330
1125630003005	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1125630003006	nucleotide binding site [chemical binding]; other site
1125630003007	SulA interaction site; other site
1125630003008	cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483
1125630003009	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
1125630003010	SecA regulator SecM; Provisional; Region: PRK02943
1125630003011	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
1125630003012	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1125630003013	SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516
1125630003014	SEC-C motif; Region: SEC-C; pfam02810
1125630003015	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
1125630003016	active site
1125630003017	8-oxo-dGMP binding site [chemical binding]; other site
1125630003018	nudix motif; other site
1125630003019	metal binding site [ion binding]; metal-binding site
1125630003020	DNA gyrase inhibitor; Reviewed; Region: PRK00418
1125630003021	hypothetical protein; Provisional; Region: PRK05287
1125630003022	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
1125630003023	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1125630003024	CoA-binding site [chemical binding]; other site
1125630003025	ATP-binding [chemical binding]; other site
1125630003026	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096
1125630003027	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1125630003028	active site
1125630003029	type IV pilin biogenesis protein; Provisional; Region: PRK10573
1125630003030	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1125630003031	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1125630003032	hypothetical protein; Provisional; Region: PRK10436
1125630003033	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
1125630003034	Walker A motif; other site
1125630003035	ATP binding site [chemical binding]; other site
1125630003036	Walker B motif; other site
1125630003037	putative major pilin subunit; Provisional; Region: PRK10574
1125630003038	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
1125630003039	Pilin (bacterial filament); Region: Pilin; pfam00114
1125630003040	quinolinate phosphoribosyltransferase; Validated; Region: PRK09016
1125630003041	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
1125630003042	dimerization interface [polypeptide binding]; other site
1125630003043	active site
1125630003044	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
1125630003045	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1125630003046	amidase catalytic site [active]
1125630003047	Zn binding residues [ion binding]; other site
1125630003048	substrate binding site [chemical binding]; other site
1125630003049	regulatory protein AmpE; Provisional; Region: PRK10987
1125630003050	Glycosyl hydrolase family 43; Region: GH43_1; cd08980
1125630003051	active site
1125630003052	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
1125630003053	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630003054	putative substrate translocation pore; other site
1125630003055	aromatic amino acid transporter; Provisional; Region: PRK10238
1125630003056	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
1125630003057	transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464
1125630003058	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1125630003059	DNA-binding site [nucleotide binding]; DNA binding site
1125630003060	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1125630003061	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
1125630003062	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
1125630003063	dimer interface [polypeptide binding]; other site
1125630003064	TPP-binding site [chemical binding]; other site
1125630003065	pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854
1125630003066	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1125630003067	E3 interaction surface; other site
1125630003068	lipoyl attachment site [posttranslational modification]; other site
1125630003069	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1125630003070	E3 interaction surface; other site
1125630003071	lipoyl attachment site [posttranslational modification]; other site
1125630003072	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1125630003073	E3 interaction surface; other site
1125630003074	lipoyl attachment site [posttranslational modification]; other site
1125630003075	e3 binding domain; Region: E3_binding; pfam02817
1125630003076	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1125630003077	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
1125630003078	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1125630003079	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1125630003080	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
1125630003081	Protein of unknown function (DUF2950); Region: DUF2950; pfam11453
1125630003082	Protein of unknown function (DUF3300); Region: DUF3300; pfam11737
1125630003083	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
1125630003084	Aconitate B N-terminal domain; Region: Aconitase_B_N; pfam11791
1125630003085	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
1125630003086	substrate binding site [chemical binding]; other site
1125630003087	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
1125630003088	substrate binding site [chemical binding]; other site
1125630003089	ligand binding site [chemical binding]; other site
1125630003090	hypothetical protein; Provisional; Region: PRK05248
1125630003091	S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462
1125630003092	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1125630003093	S-adenosylmethionine binding site [chemical binding]; other site
1125630003094	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
1125630003095	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
1125630003096	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1125630003097	putative transposase OrfB; Reviewed; Region: PHA02517
1125630003098	HTH-like domain; Region: HTH_21; pfam13276
1125630003099	Integrase core domain; Region: rve; pfam00665
1125630003100	Integrase core domain; Region: rve_3; pfam13683
1125630003101	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1125630003102	Transposase; Region: HTH_Tnp_1; cl17663
1125630003103	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
1125630003104	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1125630003105	Outer membrane lipoprotein LolB; Region: LolB; cl19307
1125630003106	Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898
1125630003107	multicopper oxidase; Provisional; Region: PRK10965
1125630003108	The first Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_1_CueO_FtsP; cd04232
1125630003109	Domain 2 interface [polypeptide binding]; other site
1125630003110	Domain 3 interface [polypeptide binding]; other site
1125630003111	trinuclear Cu binding site [ion binding]; other site
1125630003112	The second Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_2_CueO_FtsP; cd13867
1125630003113	Domain 1 interface [polypeptide binding]; other site
1125630003114	Domain 3 interface [polypeptide binding]; other site
1125630003115	The third Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_3_CueO_FtsP; cd13890
1125630003116	Domain 1 interface [polypeptide binding]; other site
1125630003117	Domain 2 interface [polypeptide binding]; other site
1125630003118	Type 1 (T1) Cu binding site [ion binding]; other site
1125630003119	trinuclear Cu binding site [ion binding]; other site
1125630003120	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
1125630003121	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
1125630003122	Trp docking motif [polypeptide binding]; other site
1125630003123	putative active site [active]
1125630003124	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1125630003125	active site
1125630003126	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
1125630003127	active site clefts [active]
1125630003128	zinc binding site [ion binding]; other site
1125630003129	dimer interface [polypeptide binding]; other site
1125630003130	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1125630003131	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1125630003132	Walker A/P-loop; other site
1125630003133	ATP binding site [chemical binding]; other site
1125630003134	Q-loop/lid; other site
1125630003135	ABC transporter signature motif; other site
1125630003136	Walker B; other site
1125630003137	D-loop; other site
1125630003138	H-loop/switch region; other site
1125630003139	inner membrane transport permease; Provisional; Region: PRK15066
1125630003140	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1125630003141	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1125630003142	active pocket/dimerization site; other site
1125630003143	active site
1125630003144	phosphorylation site [posttranslational modification]
1125630003145	Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966
1125630003146	putative active site [active]
1125630003147	putative metal binding site [ion binding]; other site
1125630003148	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
1125630003149	tetramerization interface [polypeptide binding]; other site
1125630003150	active site
1125630003151	Pantoate-beta-alanine ligase; Region: PanC; cd00560
1125630003152	active site
1125630003153	ATP-binding site [chemical binding]; other site
1125630003154	pantoate-binding site; other site
1125630003155	HXXH motif; other site
1125630003156	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
1125630003157	oligomerization interface [polypeptide binding]; other site
1125630003158	active site
1125630003159	metal binding site [ion binding]; metal-binding site
1125630003160	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1125630003161	catalytic center binding site [active]
1125630003162	ATP binding site [chemical binding]; other site
1125630003163	poly(A) polymerase; Region: pcnB; TIGR01942
1125630003164	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1125630003165	active site
1125630003166	NTP binding site [chemical binding]; other site
1125630003167	metal binding triad [ion binding]; metal-binding site
1125630003168	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1125630003169	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
1125630003170	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
1125630003171	Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008
1125630003172	active site
1125630003173	nucleotide binding site [chemical binding]; other site
1125630003174	HIGH motif; other site
1125630003175	KMSKS motif; other site
1125630003176	RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778
1125630003177	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
1125630003178	2'-5' RNA ligase; Provisional; Region: PRK15124
1125630003179	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
1125630003180	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
1125630003181	ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664
1125630003182	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1125630003183	ATP binding site [chemical binding]; other site
1125630003184	putative Mg++ binding site [ion binding]; other site
1125630003185	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1125630003186	nucleotide binding region [chemical binding]; other site
1125630003187	ATP-binding site [chemical binding]; other site
1125630003188	Helicase associated domain (HA2); Region: HA2; pfam04408
1125630003189	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
1125630003190	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
1125630003191	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
1125630003192	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
1125630003193	Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203
1125630003194	Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612
1125630003195	type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709
1125630003196	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
1125630003197	GspL periplasmic domain; Region: GspL_C; pfam12693
1125630003198	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066
1125630003199	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
1125630003200	type II secretion system protein J; Region: gspJ; TIGR01711
1125630003201	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
1125630003202	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
1125630003203	type II secretion system protein I; Region: gspI; TIGR01707
1125630003204	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
1125630003205	type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708
1125630003206	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
1125630003207	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
1125630003208	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
1125630003209	type II secretion system protein F; Region: GspF; TIGR02120
1125630003210	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1125630003211	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1125630003212	type II secretion system protein E; Region: type_II_gspE; TIGR02533
1125630003213	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
1125630003214	Walker A motif; other site
1125630003215	ATP binding site [chemical binding]; other site
1125630003216	Walker B motif; other site
1125630003217	type II secretion system protein D; Region: type_II_gspD; TIGR02517
1125630003218	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1125630003219	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1125630003220	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1125630003221	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1125630003222	type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713
1125630003223	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
1125630003224	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
1125630003225	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
1125630003226	carbohydrate binding site [chemical binding]; other site
1125630003227	alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103
1125630003228	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
1125630003229	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
1125630003230	Ca binding site [ion binding]; other site
1125630003231	active site
1125630003232	catalytic site [active]
1125630003233	Domain of unknown function (DUF3372); Region: DUF3372; pfam11852
1125630003234	putative transposase OrfB; Reviewed; Region: PHA02517
1125630003235	HTH-like domain; Region: HTH_21; pfam13276
1125630003236	Integrase core domain; Region: rve; pfam00665
1125630003237	Integrase core domain; Region: rve_2; pfam13333
1125630003238	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1125630003239	Helix-turn-helix domain; Region: HTH_28; pfam13518
1125630003240	Helix-turn-helix domain; Region: HTH_28; pfam13518
1125630003241	Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898
1125630003242	bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506
1125630003243	Transmembrane domain of transglycosylase PBP1 at N-terminal; Region: PBP1_TM; pfam14812
1125630003244	Bifunctional transglycosylase second domain; Region: UB2H; pfam14814
1125630003245	Transglycosylase; Region: Transgly; pfam00912
1125630003246	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1125630003247	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
1125630003248	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1125630003249	N-terminal plug; other site
1125630003250	ligand-binding site [chemical binding]; other site
1125630003251	iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575
1125630003252	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1125630003253	Walker A/P-loop; other site
1125630003254	ATP binding site [chemical binding]; other site
1125630003255	Q-loop/lid; other site
1125630003256	ABC transporter signature motif; other site
1125630003257	Walker B; other site
1125630003258	D-loop; other site
1125630003259	H-loop/switch region; other site
1125630003260	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1125630003261	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1125630003262	siderophore binding site; other site
1125630003263	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1125630003264	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1125630003265	ABC-ATPase subunit  interface; other site
1125630003266	dimer interface [polypeptide binding]; other site
1125630003267	putative PBP binding regions; other site
1125630003268	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1125630003269	ABC-ATPase subunit  interface; other site
1125630003270	dimer interface [polypeptide binding]; other site
1125630003271	putative PBP binding regions; other site
1125630003272	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
1125630003273	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1125630003274	inhibitor-cofactor binding pocket; inhibition site
1125630003275	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630003276	catalytic residue [active]
1125630003277	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
1125630003278	Cl- selectivity filter; other site
1125630003279	Cl- binding residues [ion binding]; other site
1125630003280	pore gating glutamate residue; other site
1125630003281	dimer interface [polypeptide binding]; other site
1125630003282	H+/Cl- coupling transport residue; other site
1125630003283	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
1125630003284	hypothetical protein; Provisional; Region: PRK10578
1125630003285	UPF0126 domain; Region: UPF0126; pfam03458
1125630003286	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1125630003287	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
1125630003288	cobalamin binding residues [chemical binding]; other site
1125630003289	putative BtuC binding residues; other site
1125630003290	dimer interface [polypeptide binding]; other site
1125630003291	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
1125630003292	deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926
1125630003293	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1125630003294	Zn2+ binding site [ion binding]; other site
1125630003295	Mg2+ binding site [ion binding]; other site
1125630003296	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
1125630003297	serine endoprotease; Provisional; Region: PRK10942
1125630003298	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1125630003299	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1125630003300	protein binding site [polypeptide binding]; other site
1125630003301	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1125630003302	carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477
1125630003303	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
1125630003304	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1125630003305	hypothetical protein; Provisional; Region: PRK13677
1125630003306	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
1125630003307	Tetrahydrodipicolinate N-succinyltransferase N-terminal; Region: THDPS_N_2; pfam14805
1125630003308	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
1125630003309	trimer interface [polypeptide binding]; other site
1125630003310	active site
1125630003311	substrate binding site [chemical binding]; other site
1125630003312	CoA binding site [chemical binding]; other site
1125630003313	PII uridylyl-transferase; Provisional; Region: PRK05007
1125630003314	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1125630003315	metal binding triad; other site
1125630003316	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1125630003317	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1125630003318	Zn2+ binding site [ion binding]; other site
1125630003319	Mg2+ binding site [ion binding]; other site
1125630003320	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
1125630003321	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
1125630003322	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1125630003323	active site
1125630003324	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1125630003325	rRNA interaction site [nucleotide binding]; other site
1125630003326	S8 interaction site; other site
1125630003327	putative laminin-1 binding site; other site
1125630003328	elongation factor Ts; Provisional; Region: tsf; PRK09377
1125630003329	UBA/TS-N domain; Region: UBA; pfam00627
1125630003330	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1125630003331	putative nucleotide binding site [chemical binding]; other site
1125630003332	uridine monophosphate binding site [chemical binding]; other site
1125630003333	homohexameric interface [polypeptide binding]; other site
1125630003334	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1125630003335	hinge region; other site
1125630003336	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
1125630003337	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
1125630003338	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
1125630003339	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
1125630003340	Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475
1125630003341	active site
1125630003342	dimer interface [polypeptide binding]; other site
1125630003343	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
1125630003344	zinc metallopeptidase RseP; Provisional; Region: PRK10779
1125630003345	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1125630003346	active site
1125630003347	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1125630003348	protein binding site [polypeptide binding]; other site
1125630003349	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1125630003350	protein binding site [polypeptide binding]; other site
1125630003351	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
1125630003352	putative substrate binding region [chemical binding]; other site
1125630003353	outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067
1125630003354	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1125630003355	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1125630003356	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1125630003357	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1125630003358	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1125630003359	Surface antigen; Region: Bac_surface_Ag; pfam01103
1125630003360	periplasmic chaperone; Provisional; Region: PRK10780
1125630003361	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
1125630003362	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
1125630003363	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
1125630003364	trimer interface [polypeptide binding]; other site
1125630003365	active site
1125630003366	UDP-GlcNAc binding site [chemical binding]; other site
1125630003367	lipid binding site [chemical binding]; lipid-binding site
1125630003368	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1125630003369	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
1125630003370	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
1125630003371	active site
1125630003372	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
1125630003373	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635
1125630003374	Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1125630003375	RNA/DNA hybrid binding site [nucleotide binding]; other site
1125630003376	active site
1125630003377	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
1125630003378	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
1125630003379	putative active site [active]
1125630003380	putative PHP Thumb interface [polypeptide binding]; other site
1125630003381	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
1125630003382	Helix-hairpin-helix motif; Region: HHH_6; pfam14579
1125630003383	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1125630003384	generic binding surface II; other site
1125630003385	generic binding surface I; other site
1125630003386	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
1125630003387	lysine decarboxylase LdcC; Provisional; Region: PRK15399
1125630003388	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
1125630003389	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
1125630003390	homodimer interface [polypeptide binding]; other site
1125630003391	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630003392	catalytic residue [active]
1125630003393	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
1125630003394	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
1125630003395	putative metal binding site [ion binding]; other site
1125630003396	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
1125630003397	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1125630003398	Ligand Binding Site [chemical binding]; other site
1125630003399	TilS substrate binding domain; Region: TilS; pfam09179
1125630003400	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
1125630003401	Rho-binding antiterminator; Provisional; Region: PRK11625
1125630003402	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681
1125630003403	hypothetical protein; Provisional; Region: PRK09256
1125630003404	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
1125630003405	lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523
1125630003406	NlpE N-terminal domain; Region: NlpE; cl19736
1125630003407	hypothetical protein; Provisional; Region: PRK11479
1125630003408	prolyl-tRNA synthetase; Provisional; Region: PRK09194
1125630003409	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1125630003410	dimer interface [polypeptide binding]; other site
1125630003411	motif 1; other site
1125630003412	active site
1125630003413	motif 2; other site
1125630003414	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
1125630003415	putative deacylase active site [active]
1125630003416	motif 3; other site
1125630003417	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1125630003418	anticodon binding site; other site
1125630003419	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
1125630003420	homodimer interaction site [polypeptide binding]; other site
1125630003421	cofactor binding site; other site
1125630003422	outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781
1125630003423	DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063
1125630003424	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630003425	dimer interface [polypeptide binding]; other site
1125630003426	conserved gate region; other site
1125630003427	putative PBP binding loops; other site
1125630003428	ABC-ATPase subunit interface; other site
1125630003429	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
1125630003430	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1125630003431	Walker A/P-loop; other site
1125630003432	ATP binding site [chemical binding]; other site
1125630003433	Q-loop/lid; other site
1125630003434	ABC transporter signature motif; other site
1125630003435	Walker B; other site
1125630003436	D-loop; other site
1125630003437	H-loop/switch region; other site
1125630003438	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
1125630003439	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
1125630003440	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1125630003441	active site
1125630003442	motif I; other site
1125630003443	motif II; other site
1125630003444	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1125630003445	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
1125630003446	active site
1125630003447	catalytic tetrad [active]
1125630003448	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630003449	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630003450	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478
1125630003451	putative effector binding pocket; other site
1125630003452	dimerization interface [polypeptide binding]; other site
1125630003453	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1125630003454	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630003455	putative substrate translocation pore; other site
1125630003456	hypothetical protein; Provisional; Region: PRK05421
1125630003457	putative catalytic site [active]
1125630003458	putative metal binding site [ion binding]; other site
1125630003459	putative phosphate binding site [ion binding]; other site
1125630003460	putative catalytic site [active]
1125630003461	putative phosphate binding site [ion binding]; other site
1125630003462	putative metal binding site [ion binding]; other site
1125630003463	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1125630003464	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1125630003465	S-adenosylmethionine binding site [chemical binding]; other site
1125630003466	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1125630003467	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1125630003468	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1125630003469	catalytic residue [active]
1125630003470	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1125630003471	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1125630003472	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1125630003473	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1125630003474	hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241
1125630003475	Methyltransferase domain; Region: Methyltransf_11; pfam08241
1125630003476	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
1125630003477	RNA/DNA hybrid binding site [nucleotide binding]; other site
1125630003478	active site
1125630003479	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
1125630003480	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
1125630003481	active site
1125630003482	catalytic site [active]
1125630003483	substrate binding site [chemical binding]; other site
1125630003484	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630003485	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630003486	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1125630003487	dimerization interface [polypeptide binding]; other site
1125630003488	LysE type translocator; Region: LysE; cl00565
1125630003489	Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575
1125630003490	putative active site [active]
1125630003491	catalytic triad [active]
1125630003492	dimer interface [polypeptide binding]; other site
1125630003493	multimer interface [polypeptide binding]; other site
1125630003494	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
1125630003495	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1125630003496	active site
1125630003497	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
1125630003498	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
1125630003499	dimer interface [polypeptide binding]; other site
1125630003500	active site
1125630003501	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
1125630003502	putative active site [active]
1125630003503	Glutamine amidotransferases class-II; Region: GATase_2; pfam00310
1125630003504	putative dimer interface [polypeptide binding]; other site
1125630003505	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
1125630003506	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1125630003507	Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352
1125630003508	RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375
1125630003509	NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973
1125630003510	Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349
1125630003511	Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869
1125630003512	Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346
1125630003513	Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292
1125630003514	Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830
1125630003515	Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464
1125630003516	Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188
1125630003517	FAD binding pocket [chemical binding]; other site
1125630003518	FAD binding motif [chemical binding]; other site
1125630003519	phosphate binding motif [ion binding]; other site
1125630003520	beta-alpha-beta structure motif; other site
1125630003521	NAD binding pocket [chemical binding]; other site
1125630003522	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2991
1125630003523	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1125630003524	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
1125630003525	active site
1125630003526	catalytic site [active]
1125630003527	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1125630003528	active site
1125630003529	DNA polymerase IV; Validated; Region: PRK02406
1125630003530	DNA binding site [nucleotide binding]
1125630003531	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1125630003532	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1125630003533	Coenzyme A binding pocket [chemical binding]; other site
1125630003534	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
1125630003535	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
1125630003536	metal binding site [ion binding]; metal-binding site
1125630003537	dimer interface [polypeptide binding]; other site
1125630003538	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1125630003539	active site
1125630003540	fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077
1125630003541	Putative lysophospholipase; Region: Hydrolase_4; cl19140
1125630003542	DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984
1125630003543	DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534
1125630003544	helix_turn_helix gluconate operon transcriptional repressor; Region: HTH_GNTR; smart00345
1125630003545	DNA-binding site [nucleotide binding]; DNA binding site
1125630003546	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1125630003547	gamma-aminobutyrate transporter; Provisional; Region: PRK10197
1125630003548	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
1125630003549	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
1125630003550	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1125630003551	inhibitor-cofactor binding pocket; inhibition site
1125630003552	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630003553	catalytic residue [active]
1125630003554	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1125630003555	tetramerization interface [polypeptide binding]; other site
1125630003556	NAD(P) binding site [chemical binding]; other site
1125630003557	catalytic residues [active]
1125630003558	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1125630003559	Predicted dehydrogenase [General function prediction only]; Region: COG0579
1125630003560	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250
1125630003561	substrate binding pocket [chemical binding]; other site
1125630003562	active site
1125630003563	iron coordination sites [ion binding]; other site
1125630003564	hypothetical protein; Provisional; Region: PRK13687
1125630003565	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1125630003566	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1125630003567	S-adenosylmethionine binding site [chemical binding]; other site
1125630003568	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1125630003569	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
1125630003570	putative C-terminal domain interface [polypeptide binding]; other site
1125630003571	putative GSH binding site (G-site) [chemical binding]; other site
1125630003572	putative dimer interface [polypeptide binding]; other site
1125630003573	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
1125630003574	N-terminal domain interface [polypeptide binding]; other site
1125630003575	dimer interface [polypeptide binding]; other site
1125630003576	substrate binding pocket (H-site) [chemical binding]; other site
1125630003577	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
1125630003578	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1125630003579	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171
1125630003580	putative ligand binding site [chemical binding]; other site
1125630003581	putative NAD binding site [chemical binding]; other site
1125630003582	catalytic site [active]
1125630003583	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1125630003584	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1125630003585	NAD(P) binding site [chemical binding]; other site
1125630003586	active site
1125630003587	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
1125630003588	L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802
1125630003589	putative N- and C-terminal domain interface [polypeptide binding]; other site
1125630003590	putative active site [active]
1125630003591	MgATP binding site [chemical binding]; other site
1125630003592	catalytic site [active]
1125630003593	metal binding site [ion binding]; metal-binding site
1125630003594	putative xylulose binding site [chemical binding]; other site
1125630003595	Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852
1125630003596	Class I aldolases; Region: Aldolase_Class_I; cl17187
1125630003597	catalytic residue [active]
1125630003598	Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674
1125630003599	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
1125630003600	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1125630003601	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1125630003602	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
1125630003603	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1125630003604	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1125630003605	E3 interaction surface; other site
1125630003606	lipoyl attachment site [posttranslational modification]; other site
1125630003607	e3 binding domain; Region: E3_binding; pfam02817
1125630003608	e3 binding domain; Region: E3_binding; pfam02817
1125630003609	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1125630003610	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1125630003611	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1125630003612	alpha subunit interface [polypeptide binding]; other site
1125630003613	TPP binding site [chemical binding]; other site
1125630003614	heterodimer interface [polypeptide binding]; other site
1125630003615	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1125630003616	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1125630003617	tetramer interface [polypeptide binding]; other site
1125630003618	TPP-binding site [chemical binding]; other site
1125630003619	heterodimer interface [polypeptide binding]; other site
1125630003620	phosphorylation loop region [posttranslational modification]
1125630003621	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
1125630003622	AAA ATPase domain; Region: AAA_16; pfam13191
1125630003623	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1125630003624	DNA binding residues [nucleotide binding]
1125630003625	dimerization interface [polypeptide binding]; other site
1125630003626	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643
1125630003627	Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778
1125630003628	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
1125630003629	active site
1125630003630	metal binding site [ion binding]; metal-binding site
1125630003631	interdomain interaction site; other site
1125630003632	D5 N terminal like; Region: D5_N; smart00885
1125630003633	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
1125630003634	Oxygenase, catalyzing oxidative methylation of damaged DNA; Region: Oxygenase-NA; cl17606
1125630003635	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
1125630003636	Ogr/Delta-like zinc finger; Region: Ogr_Delta; cl19592
1125630003637	Phage polarity suppression protein (Psu); Region: Psu; pfam07455
1125630003638	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1125630003639	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1125630003640	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1125630003641	P-loop; other site
1125630003642	Magnesium ion binding site [ion binding]; other site
1125630003643	integrase; Provisional; Region: PRK09692
1125630003644	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
1125630003645	active site
1125630003646	Int/Topo IB signature motif; other site
1125630003647	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
1125630003648	putative catalytic cysteine [active]
1125630003649	gamma-glutamyl kinase; Provisional; Region: PRK05429
1125630003650	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
1125630003651	nucleotide binding site [chemical binding]; other site
1125630003652	homotetrameric interface [polypeptide binding]; other site
1125630003653	putative phosphate binding site [ion binding]; other site
1125630003654	putative allosteric binding site; other site
1125630003655	PUA domain; Region: PUA; pfam01472
1125630003656	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1125630003657	trimer interface [polypeptide binding]; other site
1125630003658	eyelet of channel; other site
1125630003659	outer membrane lipoprotein; Provisional; Region: spr; PRK10838
1125630003660	NlpC/P60 family; Region: NLPC_P60; pfam00877
1125630003661	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1125630003662	EamA-like transporter family; Region: EamA; pfam00892
1125630003663	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
1125630003664	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
1125630003665	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1125630003666	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1125630003667	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1125630003668	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630003669	dimer interface [polypeptide binding]; other site
1125630003670	conserved gate region; other site
1125630003671	putative PBP binding loops; other site
1125630003672	ABC-ATPase subunit interface; other site
1125630003673	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
1125630003674	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
1125630003675	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
1125630003676	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
1125630003677	Walker A/P-loop; other site
1125630003678	ATP binding site [chemical binding]; other site
1125630003679	Q-loop/lid; other site
1125630003680	ABC transporter signature motif; other site
1125630003681	Walker B; other site
1125630003682	D-loop; other site
1125630003683	H-loop/switch region; other site
1125630003684	DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360
1125630003685	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1125630003686	DNA binding residues [nucleotide binding]
1125630003687	putative fimbrial protein TcfA; Provisional; Region: PRK15308
1125630003688	fimbrial outer membrane usher protein TcfC; Provisional; Region: PRK15310
1125630003689	Outer membrane usher protein; Region: Usher; pfam00577
1125630003690	Domain of unknown function (DUF4480); Region: DUF4480; pfam13715
1125630003691	amino acid ABC transporter permease; Provisional; Region: PRK15100
1125630003692	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630003693	dimer interface [polypeptide binding]; other site
1125630003694	conserved gate region; other site
1125630003695	putative PBP binding loops; other site
1125630003696	ABC-ATPase subunit interface; other site
1125630003697	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
1125630003698	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630003699	dimer interface [polypeptide binding]; other site
1125630003700	conserved gate region; other site
1125630003701	putative PBP binding loops; other site
1125630003702	ABC-ATPase subunit interface; other site
1125630003703	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1125630003704	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1125630003705	Walker A/P-loop; other site
1125630003706	ATP binding site [chemical binding]; other site
1125630003707	Q-loop/lid; other site
1125630003708	ABC transporter signature motif; other site
1125630003709	Walker B; other site
1125630003710	D-loop; other site
1125630003711	H-loop/switch region; other site
1125630003712	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1125630003713	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1125630003714	substrate binding pocket [chemical binding]; other site
1125630003715	membrane-bound complex binding site; other site
1125630003716	hinge residues; other site
1125630003717	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1125630003718	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1125630003719	Walker A/P-loop; other site
1125630003720	ATP binding site [chemical binding]; other site
1125630003721	Q-loop/lid; other site
1125630003722	ABC transporter signature motif; other site
1125630003723	Walker B; other site
1125630003724	D-loop; other site
1125630003725	H-loop/switch region; other site
1125630003726	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1125630003727	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1125630003728	Walker A/P-loop; other site
1125630003729	ATP binding site [chemical binding]; other site
1125630003730	Q-loop/lid; other site
1125630003731	ABC transporter signature motif; other site
1125630003732	Walker B; other site
1125630003733	D-loop; other site
1125630003734	H-loop/switch region; other site
1125630003735	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1125630003736	TM-ABC transporter signature motif; other site
1125630003737	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1125630003738	TM-ABC transporter signature motif; other site
1125630003739	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
1125630003740	Receptor family ligand binding region; Region: ANF_receptor; pfam01094
1125630003741	putative ligand binding site [chemical binding]; other site
1125630003742	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
1125630003743	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
1125630003744	ethanolamine permease; Region: 2A0305; TIGR00908
1125630003745	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
1125630003746	S-methylmethionine transporter; Provisional; Region: PRK11387
1125630003747	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
1125630003748	homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485
1125630003749	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1125630003750	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1125630003751	substrate binding pocket [chemical binding]; other site
1125630003752	membrane-bound complex binding site; other site
1125630003753	hinge residues; other site
1125630003754	taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248
1125630003755	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1125630003756	Walker A/P-loop; other site
1125630003757	ATP binding site [chemical binding]; other site
1125630003758	Q-loop/lid; other site
1125630003759	ABC transporter signature motif; other site
1125630003760	Walker B; other site
1125630003761	D-loop; other site
1125630003762	H-loop/switch region; other site
1125630003763	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1125630003764	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630003765	dimer interface [polypeptide binding]; other site
1125630003766	conserved gate region; other site
1125630003767	putative PBP binding loops; other site
1125630003768	ABC-ATPase subunit interface; other site
1125630003769	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
1125630003770	taurine dioxygenase; Reviewed; Region: tauD; PRK09553
1125630003771	active site
1125630003772	iron coordination sites [ion binding]; other site
1125630003773	substrate binding pocket [chemical binding]; other site
1125630003774	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986
1125630003775	putative acyl-acceptor binding pocket; other site
1125630003776	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
1125630003777	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
1125630003778	dimer interface [polypeptide binding]; other site
1125630003779	active site
1125630003780	Schiff base residues; other site
1125630003781	beta-lactam binding protein AmpH; Provisional; Region: PRK10662
1125630003782	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
1125630003783	catalytic triad [active]
1125630003784	conserved cis-peptide bond; other site
1125630003785	microcin B17 transporter; Reviewed; Region: PRK11098
1125630003786	Protein of unknown function (DUF1615); Region: DUF1615; pfam07759
1125630003787	Protein of unknown function (DUF2755); Region: DUF2755; pfam10954
1125630003788	Protein of unknown function (DUF2754); Region: DUF2754; pfam10953
1125630003789	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
1125630003790	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1125630003791	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
1125630003792	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
1125630003793	drug efflux system protein MdtG; Provisional; Region: PRK09874
1125630003794	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630003795	putative substrate translocation pore; other site
1125630003796	anti-RssB factor; Provisional; Region: PRK10244
1125630003797	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
1125630003798	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
1125630003799	active site
1125630003800	dimer interface [polypeptide binding]; other site
1125630003801	hypothetical protein; Provisional; Region: PRK11505
1125630003802	psiF repeat; Region: PsiF_repeat; pfam07769
1125630003803	psiF repeat; Region: PsiF_repeat; pfam07769
1125630003804	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
1125630003805	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
1125630003806	Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748
1125630003807	hypothetical protein; Validated; Region: PRK00124
1125630003808	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849
1125630003809	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3416
1125630003810	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
1125630003811	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1125630003812	ADP binding site [chemical binding]; other site
1125630003813	magnesium binding site [ion binding]; other site
1125630003814	putative shikimate binding site; other site
1125630003815	hypothetical protein; Provisional; Region: PRK10380
1125630003816	hypothetical protein; Provisional; Region: PRK10481
1125630003817	hypothetical protein; Provisional; Region: PRK10579
1125630003818	DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974
1125630003819	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1125630003820	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1125630003821	nucleotide binding site [chemical binding]; other site
1125630003822	Acetokinase family; Region: Acetate_kinase; cl17229
1125630003823	exonuclease subunit SbcC; Provisional; Region: PRK10246
1125630003824	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1125630003825	Walker A/P-loop; other site
1125630003826	ATP binding site [chemical binding]; other site
1125630003827	Q-loop/lid; other site
1125630003828	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1125630003829	ABC transporter signature motif; other site
1125630003830	Walker B; other site
1125630003831	D-loop; other site
1125630003832	H-loop/switch region; other site
1125630003833	exonuclease subunit SbcD; Provisional; Region: PRK10966
1125630003834	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1125630003835	active site
1125630003836	metal binding site [ion binding]; metal-binding site
1125630003837	DNA binding site [nucleotide binding]
1125630003838	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
1125630003839	transcriptional regulator PhoB; Provisional; Region: PRK10161
1125630003840	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1125630003841	active site
1125630003842	phosphorylation site [posttranslational modification]
1125630003843	intermolecular recognition site; other site
1125630003844	dimerization interface [polypeptide binding]; other site
1125630003845	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1125630003846	DNA binding site [nucleotide binding]
1125630003847	phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006
1125630003848	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
1125630003849	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1125630003850	putative active site [active]
1125630003851	heme pocket [chemical binding]; other site
1125630003852	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1125630003853	dimer interface [polypeptide binding]; other site
1125630003854	phosphorylation site [posttranslational modification]
1125630003855	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1125630003856	ATP binding site [chemical binding]; other site
1125630003857	Mg2+ binding site [ion binding]; other site
1125630003858	G-X-G motif; other site
1125630003859	branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433
1125630003860	putative proline-specific permease; Provisional; Region: proY; PRK10580
1125630003861	Spore germination protein; Region: Spore_permease; cl17796
1125630003862	maltodextrin glucosidase; Provisional; Region: PRK10785
1125630003863	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
1125630003864	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
1125630003865	active site
1125630003866	homodimer interface [polypeptide binding]; other site
1125630003867	catalytic site [active]
1125630003868	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630003869	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
1125630003870	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1125630003871	dimerization interface [polypeptide binding]; other site
1125630003872	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
1125630003873	catalytic triad [active]
1125630003874	dimer interface [polypeptide binding]; other site
1125630003875	conserved cis-peptide bond; other site
1125630003876	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
1125630003877	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
1125630003878	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
1125630003879	active site
1125630003880	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1125630003881	intersubunit interface [polypeptide binding]; other site
1125630003882	active site
1125630003883	zinc binding site [ion binding]; other site
1125630003884	Na+ binding site [ion binding]; other site
1125630003885	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1125630003886	substrate binding site [chemical binding]; other site
1125630003887	ATP binding site [chemical binding]; other site
1125630003888	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
1125630003889	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
1125630003890	active site
1125630003891	P-loop; other site
1125630003892	phosphorylation site [posttranslational modification]
1125630003893	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1125630003894	active site
1125630003895	phosphorylation site [posttranslational modification]
1125630003896	peroxidase; Provisional; Region: PRK15000
1125630003897	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1125630003898	dimer interface [polypeptide binding]; other site
1125630003899	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1125630003900	catalytic triad [active]
1125630003901	peroxidatic and resolving cysteines [active]
1125630003902	acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045
1125630003903	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
1125630003904	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
1125630003905	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
1125630003906	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
1125630003907	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
1125630003908	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
1125630003909	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
1125630003910	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
1125630003911	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
1125630003912	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
1125630003913	Protein export membrane protein; Region: SecD_SecF; pfam02355
1125630003914	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1125630003915	Predicted transcriptional regulator [Transcription]; Region: COG2378
1125630003916	HTH domain; Region: HTH_11; pfam08279
1125630003917	WYL domain; Region: WYL; pfam13280
1125630003918	nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106
1125630003919	hypothetical protein; Provisional; Region: PRK11530
1125630003920	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
1125630003921	ATP cone domain; Region: ATP-cone; pfam03477
1125630003922	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
1125630003923	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
1125630003924	catalytic motif [active]
1125630003925	Zn binding site [ion binding]; other site
1125630003926	RibD C-terminal domain; Region: RibD_C; cl17279
1125630003927	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
1125630003928	homopentamer interface [polypeptide binding]; other site
1125630003929	active site
1125630003930	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
1125630003931	thiamine monophosphate kinase; Provisional; Region: PRK05731
1125630003932	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
1125630003933	ATP binding site [chemical binding]; other site
1125630003934	dimerization interface [polypeptide binding]; other site
1125630003935	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
1125630003936	tetramer interfaces [polypeptide binding]; other site
1125630003937	binuclear metal-binding site [ion binding]; other site
1125630003938	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1125630003939	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
1125630003940	active site
1125630003941	catalytic tetrad [active]
1125630003942	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
1125630003943	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
1125630003944	TPP-binding site; other site
1125630003945	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1125630003946	PYR/PP interface [polypeptide binding]; other site
1125630003947	dimer interface [polypeptide binding]; other site
1125630003948	TPP binding site [chemical binding]; other site
1125630003949	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1125630003950	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1125630003951	substrate binding pocket [chemical binding]; other site
1125630003952	chain length determination region; other site
1125630003953	active site lid residues [active]
1125630003954	substrate-Mg2+ binding site; other site
1125630003955	catalytic residues [active]
1125630003956	aspartate-rich region 1; other site
1125630003957	aspartate-rich region 2; other site
1125630003958	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
1125630003959	tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269
1125630003960	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
1125630003961	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
1125630003962	Ligand Binding Site [chemical binding]; other site
1125630003963	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1125630003964	active site residue [active]
1125630003965	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1125630003966	hydrophobic ligand binding site; other site
1125630003967	oxidative-stress-resistance chaperone; Provisional; Region: PRK11574
1125630003968	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
1125630003969	conserved cys residue [active]
1125630003970	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
1125630003971	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1125630003972	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1125630003973	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
1125630003974	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630003975	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1125630003976	putative substrate translocation pore; other site
1125630003977	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1125630003978	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1125630003979	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1125630003980	benzoate transport; Region: 2A0115; TIGR00895
1125630003981	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630003982	putative substrate translocation pore; other site
1125630003983	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1125630003984	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1125630003985	putative FAD-binding dehydrogenase; Reviewed; Region: PRK06134
1125630003986	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1125630003987	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1125630003988	NIPSNAP; Region: NIPSNAP; pfam07978
1125630003989	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12843
1125630003990	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1125630003991	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1125630003992	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1125630003993	shikimate binding site; other site
1125630003994	NAD(P) binding site [chemical binding]; other site
1125630003995	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
1125630003996	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1125630003997	Bacterial transcriptional regulator; Region: IclR; pfam01614
1125630003998	Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957
1125630003999	putative active site [active]
1125630004000	cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582
1125630004001	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
1125630004002	Subunit I/III interface [polypeptide binding]; other site
1125630004003	Subunit III/IV interface [polypeptide binding]; other site
1125630004004	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1125630004005	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
1125630004006	D-pathway; other site
1125630004007	Putative ubiquinol binding site [chemical binding]; other site
1125630004008	Low-spin heme (heme b) binding site [chemical binding]; other site
1125630004009	Putative water exit pathway; other site
1125630004010	Binuclear center (heme o3/CuB) [ion binding]; other site
1125630004011	K-pathway; other site
1125630004012	Putative proton exit pathway; other site
1125630004013	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
1125630004014	The cupredoxin domain of Ubiquinol oxidase subunit II; Region: CuRO_UO_II; cd04212
1125630004015	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
1125630004016	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630004017	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1125630004018	putative substrate translocation pore; other site
1125630004019	hypothetical protein; Provisional; Region: PRK11627
1125630004020	transcriptional regulator BolA; Provisional; Region: PRK11628
1125630004021	trigger factor; Provisional; Region: tig; PRK01490
1125630004022	Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697
1125630004023	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1125630004024	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1125630004025	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1125630004026	oligomer interface [polypeptide binding]; other site
1125630004027	active site residues [active]
1125630004028	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1125630004029	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
1125630004030	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1125630004031	Walker A motif; other site
1125630004032	ATP binding site [chemical binding]; other site
1125630004033	Walker B motif; other site
1125630004034	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1125630004035	DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787
1125630004036	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
1125630004037	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1125630004038	Walker A motif; other site
1125630004039	ATP binding site [chemical binding]; other site
1125630004040	Walker B motif; other site
1125630004041	arginine finger; other site
1125630004042	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1125630004043	histone-like DNA-binding protein HU; Region: HU; cd13831
1125630004044	dimer interface [polypeptide binding]; other site
1125630004045	DNA binding site [nucleotide binding]
1125630004046	periplasmic folding chaperone; Provisional; Region: PRK10788
1125630004047	SurA N-terminal domain; Region: SurA_N_3; cl07813
1125630004048	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
1125630004049	comEA protein; Region: comE; TIGR01259
1125630004050	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066
1125630004051	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1125630004052	active site
1125630004053	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
1125630004054	Ligand Binding Site [chemical binding]; other site
1125630004055	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
1125630004056	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
1125630004057	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1125630004058	thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126
1125630004059	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1125630004060	active site
1125630004061	motif I; other site
1125630004062	motif II; other site
1125630004063	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
1125630004064	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1125630004065	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1125630004066	catalytic residue [active]
1125630004067	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1125630004068	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1125630004069	putative DNA binding site [nucleotide binding]; other site
1125630004070	putative Zn2+ binding site [ion binding]; other site
1125630004071	AsnC family; Region: AsnC_trans_reg; pfam01037
1125630004072	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1125630004073	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
1125630004074	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1125630004075	Walker A/P-loop; other site
1125630004076	ATP binding site [chemical binding]; other site
1125630004077	Q-loop/lid; other site
1125630004078	ABC transporter signature motif; other site
1125630004079	Walker B; other site
1125630004080	D-loop; other site
1125630004081	H-loop/switch region; other site
1125630004082	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790
1125630004083	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1125630004084	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1125630004085	Walker A/P-loop; other site
1125630004086	ATP binding site [chemical binding]; other site
1125630004087	Q-loop/lid; other site
1125630004088	ABC transporter signature motif; other site
1125630004089	Walker B; other site
1125630004090	D-loop; other site
1125630004091	H-loop/switch region; other site
1125630004092	nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665
1125630004093	ammonium transporter; Provisional; Region: PRK10666
1125630004094	acyl-CoA thioesterase II; Provisional; Region: PRK10526
1125630004095	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
1125630004096	active site
1125630004097	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
1125630004098	catalytic triad [active]
1125630004099	dimer interface [polypeptide binding]; other site
1125630004100	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126
1125630004101	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1125630004102	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1125630004103	DNA binding site [nucleotide binding]
1125630004104	active site
1125630004105	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1125630004106	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1125630004107	DNA-binding site [nucleotide binding]; DNA binding site
1125630004108	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1125630004109	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630004110	homodimer interface [polypeptide binding]; other site
1125630004111	catalytic residue [active]
1125630004112	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1125630004113	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1125630004114	nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019
1125630004115	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
1125630004116	putative homodimer interface [polypeptide binding]; other site
1125630004117	putative homotetramer interface [polypeptide binding]; other site
1125630004118	putative metal binding site [ion binding]; other site
1125630004119	putative homodimer-homodimer interface [polypeptide binding]; other site
1125630004120	putative allosteric switch controlling residues; other site
1125630004121	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
1125630004122	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
1125630004123	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1125630004124	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1125630004125	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1125630004126	Walker A/P-loop; other site
1125630004127	ATP binding site [chemical binding]; other site
1125630004128	Q-loop/lid; other site
1125630004129	ABC transporter signature motif; other site
1125630004130	Walker B; other site
1125630004131	D-loop; other site
1125630004132	H-loop/switch region; other site
1125630004133	TOBE domain; Region: TOBE_2; pfam08402
1125630004134	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
1125630004135	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1125630004136	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1125630004137	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630004138	dimer interface [polypeptide binding]; other site
1125630004139	conserved gate region; other site
1125630004140	putative PBP binding loops; other site
1125630004141	ABC-ATPase subunit interface; other site
1125630004142	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1125630004143	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630004144	dimer interface [polypeptide binding]; other site
1125630004145	conserved gate region; other site
1125630004146	putative PBP binding loops; other site
1125630004147	ABC-ATPase subunit interface; other site
1125630004148	Arabinogalactan endo-1,4-beta-galactosidase [Carbohydrate transport and metabolism]; Region: COG3867
1125630004149	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
1125630004150	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
1125630004151	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
1125630004152	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
1125630004153	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164
1125630004154	active site turn [active]
1125630004155	phosphorylation site [posttranslational modification]
1125630004156	potential frameshift: common BLAST hit: gi|238893421|ref|YP_002918155.1| maltoporin
1125630004157	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1125630004158	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1125630004159	lac repressor; Reviewed; Region: lacI; PRK09526
1125630004160	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1125630004161	DNA binding site [nucleotide binding]
1125630004162	domain linker motif; other site
1125630004163	Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574
1125630004164	ligand binding site [chemical binding]; other site
1125630004165	dimerization interface (open form) [polypeptide binding]; other site
1125630004166	dimerization interface (closed form) [polypeptide binding]; other site
1125630004167	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
1125630004168	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
1125630004169	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1125630004170	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1125630004171	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1125630004172	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1125630004173	DNA-binding site [nucleotide binding]; DNA binding site
1125630004174	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1125630004175	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630004176	homodimer interface [polypeptide binding]; other site
1125630004177	catalytic residue [active]
1125630004178	Inner membrane protein YlaC; Region: YlaC; pfam10777
1125630004179	maltose O-acetyltransferase; Provisional; Region: PRK10092
1125630004180	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
1125630004181	active site
1125630004182	substrate binding site [chemical binding]; other site
1125630004183	trimer interface [polypeptide binding]; other site
1125630004184	CoA binding site [chemical binding]; other site
1125630004185	gene expression modulator; Provisional; Region: PRK10945
1125630004186	Hha toxicity attenuator; Provisional; Region: PRK10667
1125630004187	multidrug efflux system protein AcrB; Provisional; Region: PRK15127
1125630004188	MMPL family; Region: MMPL; cl14618
1125630004189	MMPL family; Region: MMPL; cl14618
1125630004190	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
1125630004191	Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169
1125630004192	HlyD family secretion protein; Region: HlyD_3; pfam13437
1125630004193	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
1125630004194	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1125630004195	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
1125630004196	hypothetical protein; Provisional; Region: PRK11281
1125630004197	M domain of GW182; Region: M_domain; pfam12938
1125630004198	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
1125630004199	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
1125630004200	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1125630004201	putative transposase; Provisional; Region: PRK09857
1125630004202	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
1125630004203	hypothetical protein; Provisional; Region: PRK11038
1125630004204	primosomal replication protein N''; Provisional; Region: PRK10093
1125630004205	hypothetical protein; Provisional; Region: PRK10527
1125630004206	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1125630004207	active site
1125630004208	potential frameshift: common BLAST hit: gi|238893440|ref|YP_002918174.1| DNA polymerase III subunits gamma and tau
1125630004209	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14961
1125630004210	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1125630004211	Walker A motif; other site
1125630004212	ATP binding site [chemical binding]; other site
1125630004213	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944
1125630004214	Walker B motif; other site
1125630004215	arginine finger; other site
1125630004216	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
1125630004217	DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168
1125630004218	DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170
1125630004219	hypothetical protein; Validated; Region: PRK00153
1125630004220	recombination protein RecR; Reviewed; Region: recR; PRK00076
1125630004221	RecR protein; Region: RecR; pfam02132
1125630004222	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1125630004223	putative active site [active]
1125630004224	putative metal-binding site [ion binding]; other site
1125630004225	tetramer interface [polypeptide binding]; other site
1125630004226	heat shock protein 90; Provisional; Region: PRK05218
1125630004227	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1125630004228	ATP binding site [chemical binding]; other site
1125630004229	Mg2+ binding site [ion binding]; other site
1125630004230	G-X-G motif; other site
1125630004231	Hsp90 protein; Region: HSP90; pfam00183
1125630004232	adenylate kinase; Reviewed; Region: adk; PRK00279
1125630004233	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1125630004234	AMP-binding site [chemical binding]; other site
1125630004235	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1125630004236	ferrochelatase; Reviewed; Region: hemH; PRK00035
1125630004237	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
1125630004238	C-terminal domain interface [polypeptide binding]; other site
1125630004239	active site
1125630004240	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
1125630004241	active site
1125630004242	N-terminal domain interface [polypeptide binding]; other site
1125630004243	inosine/guanosine kinase; Provisional; Region: PRK15074
1125630004244	substrate binding site [chemical binding]; other site
1125630004245	ATP binding site [chemical binding]; other site
1125630004246	putative cation:proton antiport protein; Provisional; Region: PRK10669
1125630004247	Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651
1125630004248	TrkA-N domain; Region: TrkA_N; pfam02254
1125630004249	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630004250	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1125630004251	putative substrate translocation pore; other site
1125630004252	bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558
1125630004253	Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405
1125630004254	active site
1125630004255	metal binding site [ion binding]; metal-binding site
1125630004256	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1125630004257	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
1125630004258	putative deacylase active site [active]
1125630004259	TraB family; Region: TraB; cl12050
1125630004260	copper exporting ATPase; Provisional; Region: copA; PRK10671
1125630004261	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1125630004262	metal-binding site [ion binding]
1125630004263	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1125630004264	metal-binding site [ion binding]
1125630004265	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1125630004266	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1125630004267	motif II; other site
1125630004268	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1125630004269	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
1125630004270	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1125630004271	Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_paraslipin; cd08829
1125630004272	core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107
1125630004273	putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247
1125630004274	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1125630004275	Walker A/P-loop; other site
1125630004276	ATP binding site [chemical binding]; other site
1125630004277	Q-loop/lid; other site
1125630004278	ABC transporter signature motif; other site
1125630004279	Walker B; other site
1125630004280	D-loop; other site
1125630004281	H-loop/switch region; other site
1125630004282	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
1125630004283	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
1125630004284	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
1125630004285	Tetratricopeptide repeat; Region: TPR_20; pfam14561
1125630004286	short chain dehydrogenase; Validated; Region: PRK06182
1125630004287	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
1125630004288	NADP binding site [chemical binding]; other site
1125630004289	active site
1125630004290	steroid binding site; other site
1125630004291	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
1125630004292	active site
1125630004293	catalytic triad [active]
1125630004294	oxyanion hole [active]
1125630004295	switch loop; other site
1125630004296	putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584
1125630004297	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1125630004298	Walker A/P-loop; other site
1125630004299	ATP binding site [chemical binding]; other site
1125630004300	Q-loop/lid; other site
1125630004301	ABC transporter signature motif; other site
1125630004302	Walker B; other site
1125630004303	D-loop; other site
1125630004304	H-loop/switch region; other site
1125630004305	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
1125630004306	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1125630004307	FtsX-like permease family; Region: FtsX; pfam02687
1125630004308	FtsX-like permease family; Region: FtsX; pfam02687
1125630004309	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1125630004310	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
1125630004311	Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520
1125630004312	active site residue [active]
1125630004313	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
1125630004314	ATP-grasp domain; Region: ATP-grasp; pfam02222
1125630004315	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
1125630004316	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
1125630004317	putative active site [active]
1125630004318	putative metal binding site [ion binding]; other site
1125630004319	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
1125630004320	substrate binding site [chemical binding]; other site
1125630004321	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1125630004322	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1125630004323	active site
1125630004324	HIGH motif; other site
1125630004325	KMSKS motif; other site
1125630004326	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
1125630004327	tRNA binding surface [nucleotide binding]; other site
1125630004328	anticodon binding site; other site
1125630004329	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1125630004330	RNA binding surface [nucleotide binding]; other site
1125630004331	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
1125630004332	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1125630004333	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1125630004334	homodimer interface [polypeptide binding]; other site
1125630004335	NADP binding site [chemical binding]; other site
1125630004336	substrate binding site [chemical binding]; other site
1125630004337	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
1125630004338	P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192
1125630004339	Int/Topo IB signature motif; other site
1125630004340	DksA-like zinc finger domain containing protein; Region: PHA00080
1125630004341	DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869
1125630004342	YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588
1125630004343	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1125630004344	Predicted transcriptional regulator [Transcription]; Region: COG2932
1125630004345	Catalytic site [active]
1125630004346	Helix-turn-helix domain; Region: HTH_17; pfam12728
1125630004347	Bacteriophage CII protein; Region: Phage_CII; pfam05269
1125630004348	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1125630004349	phage replicative helicase, DnaB family, HK022 subfamily; Region: phage_DnaB; TIGR03600
1125630004350	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1125630004351	Walker A motif; other site
1125630004352	ATP binding site [chemical binding]; other site
1125630004353	Walker B motif; other site
1125630004354	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
1125630004355	putative Zn2+ binding site [ion binding]; other site
1125630004356	putative DNA binding site [nucleotide binding]; other site
1125630004357	Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935
1125630004358	Protein of unknown function (DUF550); Region: DUF550; pfam04447
1125630004359	Protein of unknown function (DUF551); Region: DUF551; pfam04448
1125630004360	hypothetical protein; Provisional; Region: PRK09741
1125630004361	Bacteriophage Lambda NinG protein; Region: NinG; pfam05766
1125630004362	Lysis protein S; Region: Lysis_S; pfam04971
1125630004363	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
1125630004364	catalytic residues [active]
1125630004365	Uncharacterized conserved protein (DUF2280); Region: DUF2280; cl02353
1125630004366	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410
1125630004367	Phage-related terminase [General function prediction only]; Region: COG5362; cl02216
1125630004368	Protein of unknown function (DUF1073); Region: DUF1073; pfam06381
1125630004369	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1125630004370	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
1125630004371	VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173
1125630004372	active site
1125630004373	ADP-ribosylating toxin turn-turn motif; other site
1125630004374	Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; cl19842
1125630004375	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
1125630004376	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1125630004377	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
1125630004378	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1125630004379	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1125630004380	Protein of unknown function (DUF3383); Region: DUF3383; pfam11863
1125630004381	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
1125630004382	ORF11CD3 domain; Region: ORF11CD3; pfam10549
1125630004383	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1125630004384	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1125630004385	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1125630004386	catalytic residue [active]
1125630004387	Arc-like DNA binding domain; Region: Arc; pfam03869
1125630004388	P22_AR N-terminal domain; Region: P22_AR_N; pfam10547
1125630004389	Prophage antirepressor [Transcription]; Region: COG3617
1125630004390	Protein of unknown function (DUF2612); Region: DUF2612; pfam11041
1125630004391	Phage Tail Collar Domain; Region: Collar; pfam07484
1125630004392	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
1125630004393	active site
1125630004394	homotetramer interface [polypeptide binding]; other site
1125630004395	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
1125630004396	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
1125630004397	dimer interface [polypeptide binding]; other site
1125630004398	active site
1125630004399	citrylCoA binding site [chemical binding]; other site
1125630004400	NADH binding [chemical binding]; other site
1125630004401	cationic pore residues; other site
1125630004402	oxalacetate/citrate binding site [chemical binding]; other site
1125630004403	coenzyme A binding site [chemical binding]; other site
1125630004404	catalytic triad [active]
1125630004405	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
1125630004406	DNA binding residues [nucleotide binding]
1125630004407	dimerization interface [polypeptide binding]; other site
1125630004408	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
1125630004409	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
1125630004410	Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345
1125630004411	Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753
1125630004412	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
1125630004413	PapC N-terminal domain; Region: PapC_N; pfam13954
1125630004414	Outer membrane usher protein; Region: Usher; pfam00577
1125630004415	PapC C-terminal domain; Region: PapC_C; pfam13953
1125630004416	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
1125630004417	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1125630004418	Coenzyme A binding pocket [chemical binding]; other site
1125630004419	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1125630004420	putative acyl-acceptor binding pocket; other site
1125630004421	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
1125630004422	DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153
1125630004423	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1125630004424	DNA binding site [nucleotide binding]
1125630004425	lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435
1125630004426	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
1125630004427	lysine decarboxylase CadA; Provisional; Region: PRK15400
1125630004428	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
1125630004429	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
1125630004430	homodimer interface [polypeptide binding]; other site
1125630004431	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630004432	catalytic residue [active]
1125630004433	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
1125630004434	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
1125630004435	POT family; Region: PTR2; cl17359
1125630004436	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630004437	putative substrate translocation pore; other site
1125630004438	lysyl-tRNA synthetase; Reviewed; Region: PRK12445
1125630004439	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1125630004440	dimer interface [polypeptide binding]; other site
1125630004441	putative anticodon binding site; other site
1125630004442	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
1125630004443	motif 1; other site
1125630004444	active site
1125630004445	motif 2; other site
1125630004446	motif 3; other site
1125630004447	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1125630004448	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1125630004449	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1125630004450	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1125630004451	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1125630004452	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1125630004453	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1125630004454	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1125630004455	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1125630004456	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1125630004457	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1125630004458	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1125630004459	DNA binding site [nucleotide binding]
1125630004460	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1125630004461	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1125630004462	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
1125630004463	putative ligand binding site [chemical binding]; other site
1125630004464	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1125630004465	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1125630004466	Walker A/P-loop; other site
1125630004467	ATP binding site [chemical binding]; other site
1125630004468	Q-loop/lid; other site
1125630004469	ABC transporter signature motif; other site
1125630004470	Walker B; other site
1125630004471	D-loop; other site
1125630004472	H-loop/switch region; other site
1125630004473	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1125630004474	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1125630004475	TM-ABC transporter signature motif; other site
1125630004476	D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417
1125630004477	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1125630004478	DNA binding site [nucleotide binding]
1125630004479	domain linker motif; other site
1125630004480	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
1125630004481	dimerization interface [polypeptide binding]; other site
1125630004482	ligand binding site [chemical binding]; other site
1125630004483	sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322
1125630004484	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1125630004485	substrate binding [chemical binding]; other site
1125630004486	active site
1125630004487	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1125630004488	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
1125630004489	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1125630004490	active site turn [active]
1125630004491	phosphorylation site [posttranslational modification]
1125630004492	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1125630004493	Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471
1125630004494	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
1125630004495	maltoporin; Provisional; Region: lamB; PRK09360
1125630004496	trimer interface; other site
1125630004497	sugar binding site [chemical binding]; other site
1125630004498	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
1125630004499	putative substrate binding site [chemical binding]; other site
1125630004500	putative ATP binding site [chemical binding]; other site
1125630004501	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1125630004502	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832
1125630004503	Protein of unknown function (DUF3302); Region: DUF3302; pfam11742
1125630004504	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
1125630004505	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1125630004506	HlyD family secretion protein; Region: HlyD_3; pfam13437
1125630004507	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1125630004508	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1125630004509	Walker A/P-loop; other site
1125630004510	ATP binding site [chemical binding]; other site
1125630004511	Q-loop/lid; other site
1125630004512	ABC transporter signature motif; other site
1125630004513	Walker B; other site
1125630004514	D-loop; other site
1125630004515	H-loop/switch region; other site
1125630004516	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1125630004517	ABC-ATPase subunit  interface; other site
1125630004518	dimer interface [polypeptide binding]; other site
1125630004519	putative PBP binding regions; other site
1125630004520	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1125630004521	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1125630004522	intersubunit interface [polypeptide binding]; other site
1125630004523	Domain of unknown function (DUF3315); Region: DUF3315; pfam11776
1125630004524	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1125630004525	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
1125630004526	metal binding site [ion binding]; metal-binding site
1125630004527	putative dimer interface [polypeptide binding]; other site
1125630004528	histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437
1125630004529	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1125630004530	substrate binding pocket [chemical binding]; other site
1125630004531	membrane-bound complex binding site; other site
1125630004532	hinge residues; other site
1125630004533	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1125630004534	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
1125630004535	active site
1125630004536	catalytic tetrad [active]
1125630004537	Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703
1125630004538	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1125630004539	classical (c) SDRs; Region: SDR_c; cd05233
1125630004540	NAD(P) binding site [chemical binding]; other site
1125630004541	active site
1125630004542	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
1125630004543	Sulfatase; Region: Sulfatase; pfam00884
1125630004544	C-terminal region of aryl-sulfatase; Region: Sulfatase_C; pfam14707
1125630004545	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
1125630004546	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1125630004547	FeS/SAM binding site; other site
1125630004548	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
1125630004549	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1125630004550	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1125630004551	DNA binding residues [nucleotide binding]
1125630004552	dimerization interface [polypeptide binding]; other site
1125630004553	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630004554	putative substrate translocation pore; other site
1125630004555	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1125630004556	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996
1125630004557	active site
1125630004558	Zn binding site [ion binding]; other site
1125630004559	Protein of unknown function (DUF3156); Region: DUF3156; pfam11354
1125630004560	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1125630004561	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
1125630004562	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
1125630004563	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1125630004564	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1125630004565	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1125630004566	NAD(P) binding site [chemical binding]; other site
1125630004567	catalytic residues [active]
1125630004568	PQQ-like domain; Region: PQQ_2; pfam13360
1125630004569	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1125630004570	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1125630004571	N-terminal plug; other site
1125630004572	ligand-binding site [chemical binding]; other site
1125630004573	phenylalanine transporter; Provisional; Region: PRK10249
1125630004574	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
1125630004575	Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825
1125630004576	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630004577	putative substrate translocation pore; other site
1125630004578	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1125630004579	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1125630004580	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
1125630004581	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1125630004582	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1125630004583	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1125630004584	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
1125630004585	DNA binding residues [nucleotide binding]
1125630004586	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
1125630004587	Outer membrane usher protein; Region: Usher; pfam00577
1125630004588	putative fimbrial protein TcfA; Provisional; Region: PRK15308
1125630004589	Vi polysaccharide biosynthesis protein TviA; Provisional; Region: PRK15183
1125630004590	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1125630004591	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
1125630004592	DNA binding residues [nucleotide binding]
1125630004593	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
1125630004594	nudix motif; other site
1125630004595	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1125630004596	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1125630004597	DNA binding site [nucleotide binding]
1125630004598	domain linker motif; other site
1125630004599	Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284
1125630004600	dimerization interface [polypeptide binding]; other site
1125630004601	ligand binding site [chemical binding]; other site
1125630004602	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1125630004603	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1125630004604	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630004605	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1125630004606	putative substrate translocation pore; other site
1125630004607	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1125630004608	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1125630004609	salt bridge; other site
1125630004610	non-specific DNA binding site [nucleotide binding]; other site
1125630004611	sequence-specific DNA binding site [nucleotide binding]; other site
1125630004612	potential frameshift: common BLAST hit: gi|152969117|ref|YP_001334226.1| putative inner membrane protein
1125630004613	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944
1125630004614	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
1125630004615	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1125630004616	Walker B motif; other site
1125630004617	arginine finger; other site
1125630004618	Transcriptional antiterminator [Transcription]; Region: COG3933
1125630004619	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1125630004620	active pocket/dimerization site; other site
1125630004621	active site
1125630004622	phosphorylation site [posttranslational modification]
1125630004623	PRD domain; Region: PRD; pfam00874
1125630004624	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
1125630004625	A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710
1125630004626	putative active site [active]
1125630004627	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1125630004628	dimer interface [polypeptide binding]; other site
1125630004629	active site
1125630004630	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
1125630004631	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1125630004632	dimer interface [polypeptide binding]; other site
1125630004633	active site
1125630004634	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1125630004635	dimer interface [polypeptide binding]; other site
1125630004636	active site
1125630004637	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
1125630004638	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
1125630004639	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
1125630004640	active site
1125630004641	phosphorylation site [posttranslational modification]
1125630004642	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1125630004643	active site
1125630004644	active pocket/dimerization site; other site
1125630004645	phosphorylation site [posttranslational modification]
1125630004646	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
1125630004647	dimer interface [polypeptide binding]; other site
1125630004648	FMN binding site [chemical binding]; other site
1125630004649	hypothetical protein; Provisional; Region: PRK10250
1125630004650	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1125630004651	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1125630004652	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1125630004653	DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219
1125630004654	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630004655	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630004656	Protein of unknown function (DUF1158); Region: DUF1158; pfam06643
1125630004657	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
1125630004658	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1125630004659	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1125630004660	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1125630004661	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
1125630004662	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1125630004663	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1125630004664	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1125630004665	HlyD family secretion protein; Region: HlyD_3; pfam13437
1125630004666	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1125630004667	MMPL family; Region: MMPL; cl14618
1125630004668	MMPL family; Region: MMPL; cl14618
1125630004669	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1125630004670	Helix-turn-helix domain; Region: HTH_28; pfam13518
1125630004671	Helix-turn-helix domain; Region: HTH_28; pfam13518
1125630004672	putative transposase OrfB; Reviewed; Region: PHA02517
1125630004673	HTH-like domain; Region: HTH_21; pfam13276
1125630004674	Integrase core domain; Region: rve; pfam00665
1125630004675	Integrase core domain; Region: rve_2; pfam13333
1125630004676	Predicted periplasmic protein (DUF2233); Region: DUF2233; cl19845
1125630004677	gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516
1125630004678	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1125630004679	EamA-like transporter family; Region: EamA; pfam00892
1125630004680	EamA-like transporter family; Region: EamA; pfam00892
1125630004681	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1125630004682	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1125630004683	DNA-binding site [nucleotide binding]; DNA binding site
1125630004684	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1125630004685	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630004686	homodimer interface [polypeptide binding]; other site
1125630004687	catalytic residue [active]
1125630004688	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1125630004689	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1125630004690	DNA-binding site [nucleotide binding]; DNA binding site
1125630004691	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1125630004692	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630004693	homodimer interface [polypeptide binding]; other site
1125630004694	catalytic residue [active]
1125630004695	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1125630004696	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1125630004697	substrate binding pocket [chemical binding]; other site
1125630004698	membrane-bound complex binding site; other site
1125630004699	hinge residues; other site
1125630004700	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
1125630004701	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630004702	dimer interface [polypeptide binding]; other site
1125630004703	conserved gate region; other site
1125630004704	putative PBP binding loops; other site
1125630004705	ABC-ATPase subunit interface; other site
1125630004706	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
1125630004707	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630004708	dimer interface [polypeptide binding]; other site
1125630004709	conserved gate region; other site
1125630004710	putative PBP binding loops; other site
1125630004711	ABC-ATPase subunit interface; other site
1125630004712	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1125630004713	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1125630004714	Walker A/P-loop; other site
1125630004715	ATP binding site [chemical binding]; other site
1125630004716	Q-loop/lid; other site
1125630004717	ABC transporter signature motif; other site
1125630004718	Walker B; other site
1125630004719	D-loop; other site
1125630004720	H-loop/switch region; other site
1125630004721	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1125630004722	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1125630004723	NAD(P) binding site [chemical binding]; other site
1125630004724	active site
1125630004725	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
1125630004726	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1125630004727	inhibitor-cofactor binding pocket; inhibition site
1125630004728	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630004729	catalytic residue [active]
1125630004730	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1125630004731	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1125630004732	Walker A/P-loop; other site
1125630004733	ATP binding site [chemical binding]; other site
1125630004734	Q-loop/lid; other site
1125630004735	ABC transporter signature motif; other site
1125630004736	Walker B; other site
1125630004737	D-loop; other site
1125630004738	H-loop/switch region; other site
1125630004739	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1125630004740	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1125630004741	Walker A/P-loop; other site
1125630004742	ATP binding site [chemical binding]; other site
1125630004743	Q-loop/lid; other site
1125630004744	ABC transporter signature motif; other site
1125630004745	Walker B; other site
1125630004746	D-loop; other site
1125630004747	H-loop/switch region; other site
1125630004748	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1125630004749	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1125630004750	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630004751	dimer interface [polypeptide binding]; other site
1125630004752	conserved gate region; other site
1125630004753	putative PBP binding loops; other site
1125630004754	ABC-ATPase subunit interface; other site
1125630004755	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1125630004756	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630004757	dimer interface [polypeptide binding]; other site
1125630004758	conserved gate region; other site
1125630004759	putative PBP binding loops; other site
1125630004760	ABC-ATPase subunit interface; other site
1125630004761	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1125630004762	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
1125630004763	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1125630004764	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1125630004765	choline dehydrogenase; Validated; Region: PRK02106
1125630004766	GMC oxidoreductase; Region: GMC_oxred_N; pfam00732
1125630004767	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1125630004768	NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090
1125630004769	tetrameric interface [polypeptide binding]; other site
1125630004770	NAD binding site [chemical binding]; other site
1125630004771	catalytic residues [active]
1125630004772	transcriptional regulator BetI; Validated; Region: PRK00767
1125630004773	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1125630004774	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1125630004775	choline transport protein BetT; Provisional; Region: PRK09928
1125630004776	C-lysozyme inhibitor; Provisional; Region: PRK09993
1125630004777	potential frameshift: common BLAST hit: gi|152969159|ref|YP_001334268.1| putative transport
1125630004778	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1125630004779	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1125630004780	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1125630004781	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630004782	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1125630004783	dimerization interface [polypeptide binding]; other site
1125630004784	substrate binding pocket [chemical binding]; other site
1125630004785	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1125630004786	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
1125630004787	C-terminal domain interface [polypeptide binding]; other site
1125630004788	GSH binding site (G-site) [chemical binding]; other site
1125630004789	dimer interface [polypeptide binding]; other site
1125630004790	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
1125630004791	N-terminal domain interface [polypeptide binding]; other site
1125630004792	dimer interface [polypeptide binding]; other site
1125630004793	substrate binding pocket (H-site) [chemical binding]; other site
1125630004794	short chain dehydrogenase; Provisional; Region: PRK06114
1125630004795	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1125630004796	NAD(P) binding site [chemical binding]; other site
1125630004797	active site
1125630004798	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1125630004799	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1125630004800	NAD(P) binding site [chemical binding]; other site
1125630004801	active site
1125630004802	potential frameshift: common BLAST hit: gi|288936628|ref|YP_003440687.1| inner-membrane translocator
1125630004803	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
1125630004804	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1125630004805	TM-ABC transporter signature motif; other site
1125630004806	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1125630004807	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1125630004808	Walker A/P-loop; other site
1125630004809	ATP binding site [chemical binding]; other site
1125630004810	Q-loop/lid; other site
1125630004811	ABC transporter signature motif; other site
1125630004812	Walker B; other site
1125630004813	D-loop; other site
1125630004814	H-loop/switch region; other site
1125630004815	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1125630004816	Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; cl02395
1125630004817	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1125630004818	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1125630004819	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
1125630004820	bacterial glycerol kinase 2-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK2_bacteria; cd07791
1125630004821	N- and C-terminal domain interface [polypeptide binding]; other site
1125630004822	active site
1125630004823	MgATP binding site [chemical binding]; other site
1125630004824	catalytic site [active]
1125630004825	metal binding site [ion binding]; metal-binding site
1125630004826	putative homotetramer interface [polypeptide binding]; other site
1125630004827	putative homodimer interface [polypeptide binding]; other site
1125630004828	glycerol binding site [chemical binding]; other site
1125630004829	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1125630004830	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1125630004831	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1125630004832	TPP-binding site [chemical binding]; other site
1125630004833	dimer interface [polypeptide binding]; other site
1125630004834	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
1125630004835	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1125630004836	PYR/PP interface [polypeptide binding]; other site
1125630004837	dimer interface [polypeptide binding]; other site
1125630004838	TPP binding site [chemical binding]; other site
1125630004839	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1125630004840	phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251
1125630004841	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
1125630004842	outer membrane receptor FepA; Provisional; Region: PRK13524
1125630004843	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1125630004844	N-terminal plug; other site
1125630004845	ligand-binding site [chemical binding]; other site
1125630004846	enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439
1125630004847	Domain of unknown function (DUF3327); Region: DUF3327; pfam11806
1125630004848	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187
1125630004849	MbtH-like protein; Region: MbtH; cl01279
1125630004850	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
1125630004851	Condensation domain; Region: Condensation; cl19241
1125630004852	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1125630004853	acyl-activating enzyme (AAE) consensus motif; other site
1125630004854	AMP binding site [chemical binding]; other site
1125630004855	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1125630004856	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
1125630004857	iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253
1125630004858	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1125630004859	Walker A/P-loop; other site
1125630004860	ATP binding site [chemical binding]; other site
1125630004861	Q-loop/lid; other site
1125630004862	ABC transporter signature motif; other site
1125630004863	Walker B; other site
1125630004864	D-loop; other site
1125630004865	H-loop/switch region; other site
1125630004866	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1125630004867	ABC-ATPase subunit  interface; other site
1125630004868	dimer interface [polypeptide binding]; other site
1125630004869	putative PBP binding regions; other site
1125630004870	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1125630004871	ABC-ATPase subunit  interface; other site
1125630004872	dimer interface [polypeptide binding]; other site
1125630004873	putative PBP binding regions; other site
1125630004874	enterobactin exporter EntS; Provisional; Region: PRK10489
1125630004875	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630004876	putative substrate translocation pore; other site
1125630004877	iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957
1125630004878	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1125630004879	siderophore binding site; other site
1125630004880	isochorismate synthase EntC; Provisional; Region: PRK15016
1125630004881	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1125630004882	enterobactin synthase subunit E; Provisional; Region: entE; PRK10946
1125630004883	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
1125630004884	acyl-activating enzyme (AAE) consensus motif; other site
1125630004885	active site
1125630004886	AMP binding site [chemical binding]; other site
1125630004887	substrate binding site [chemical binding]; other site
1125630004888	Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013
1125630004889	hydrophobic substrate binding pocket; other site
1125630004890	active site
1125630004891	conserved cis-peptide bond; other site
1125630004892	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
1125630004893	2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220
1125630004894	2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331
1125630004895	putative NAD(P) binding site [chemical binding]; other site
1125630004896	active site
1125630004897	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1125630004898	CoenzymeA binding site [chemical binding]; other site
1125630004899	subunit interaction site [polypeptide binding]; other site
1125630004900	PHB binding site; other site
1125630004901	carbon starvation protein A; Provisional; Region: PRK15015
1125630004902	Carbon starvation protein CstA; Region: CstA; pfam02554
1125630004903	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
1125630004904	Uncharacterized small protein [Function unknown]; Region: COG2879
1125630004905	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1125630004906	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1125630004907	salt bridge; other site
1125630004908	non-specific DNA binding site [nucleotide binding]; other site
1125630004909	sequence-specific DNA binding site [nucleotide binding]; other site
1125630004910	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
1125630004911	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1125630004912	classical (c) SDRs; Region: SDR_c; cd05233
1125630004913	NAD(P) binding site [chemical binding]; other site
1125630004914	active site
1125630004915	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
1125630004916	putative active site [active]
1125630004917	metal binding site [ion binding]; metal-binding site
1125630004918	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1125630004919	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1125630004920	Walker A/P-loop; other site
1125630004921	ATP binding site [chemical binding]; other site
1125630004922	Q-loop/lid; other site
1125630004923	ABC transporter signature motif; other site
1125630004924	Walker B; other site
1125630004925	D-loop; other site
1125630004926	H-loop/switch region; other site
1125630004927	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1125630004928	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1125630004929	TM-ABC transporter signature motif; other site
1125630004930	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1125630004931	Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305
1125630004932	putative ligand binding site [chemical binding]; other site
1125630004933	Uncharacterized conserved protein [Function unknown]; Region: COG5276
1125630004934	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1125630004935	Helix-turn-helix domain; Region: HTH_28; pfam13518
1125630004936	Helix-turn-helix domain; Region: HTH_28; pfam13518
1125630004937	putative transposase OrfB; Reviewed; Region: PHA02517
1125630004938	HTH-like domain; Region: HTH_21; pfam13276
1125630004939	Integrase core domain; Region: rve; pfam00665
1125630004940	Integrase core domain; Region: rve_2; pfam13333
1125630004941	methylthioribose kinase; Reviewed; Region: mtnK; PRK09550
1125630004942	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
1125630004943	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
1125630004944	catalytic core [active]
1125630004945	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
1125630004946	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630004947	putative substrate translocation pore; other site
1125630004948	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
1125630004949	active site
1125630004950	dimerization interface [polypeptide binding]; other site
1125630004951	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1125630004952	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1125630004953	DNA binding site [nucleotide binding]
1125630004954	domain linker motif; other site
1125630004955	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278
1125630004956	putative dimerization interface [polypeptide binding]; other site
1125630004957	putative ligand binding site [chemical binding]; other site
1125630004958	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
1125630004959	cytosine deaminase; Provisional; Region: PRK05985
1125630004960	active site
1125630004961	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
1125630004962	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1125630004963	cytosine permease; Provisional; Region: codB; PRK11017
1125630004964	Na binding site [ion binding]; other site
1125630004965	methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220
1125630004966	intersubunit interface [polypeptide binding]; other site
1125630004967	active site
1125630004968	Zn2+ binding site [ion binding]; other site
1125630004969	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
1125630004970	L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802
1125630004971	putative N- and C-terminal domain interface [polypeptide binding]; other site
1125630004972	putative active site [active]
1125630004973	MgATP binding site [chemical binding]; other site
1125630004974	catalytic site [active]
1125630004975	metal binding site [ion binding]; metal-binding site
1125630004976	putative xylulose binding site [chemical binding]; other site
1125630004977	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1125630004978	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171
1125630004979	putative ligand binding site [chemical binding]; other site
1125630004980	putative NAD binding site [chemical binding]; other site
1125630004981	catalytic site [active]
1125630004982	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1125630004983	substrate binding site [chemical binding]; other site
1125630004984	ATP binding site [chemical binding]; other site
1125630004985	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1125630004986	TM-ABC transporter signature motif; other site
1125630004987	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1125630004988	TM-ABC transporter signature motif; other site
1125630004989	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1125630004990	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1125630004991	Walker A/P-loop; other site
1125630004992	ATP binding site [chemical binding]; other site
1125630004993	Q-loop/lid; other site
1125630004994	ABC transporter signature motif; other site
1125630004995	Walker B; other site
1125630004996	D-loop; other site
1125630004997	H-loop/switch region; other site
1125630004998	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1125630004999	Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305
1125630005000	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1125630005001	putative ligand binding site [chemical binding]; other site
1125630005002	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1125630005003	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
1125630005004	molybdopterin cofactor binding site; other site
1125630005005	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
1125630005006	molybdopterin cofactor binding site; other site
1125630005007	Cupin domain; Region: Cupin_2; cl17218
1125630005008	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
1125630005009	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
1125630005010	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1125630005011	motif II; other site
1125630005012	methionine aminotransferase; Validated; Region: PRK09082
1125630005013	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1125630005014	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630005015	homodimer interface [polypeptide binding]; other site
1125630005016	catalytic residue [active]
1125630005017	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
1125630005018	ParB-like nuclease domain; Region: ParBc; pfam02195
1125630005019	Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969
1125630005020	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1125630005021	Active Sites [active]
1125630005022	Domain of unknown function (DUF3440); Region: DUF3440; pfam11922
1125630005023	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482
1125630005024	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630005025	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1125630005026	dimerization interface [polypeptide binding]; other site
1125630005027	disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657
1125630005028	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
1125630005029	dimerization domain [polypeptide binding]; other site
1125630005030	dimer interface [polypeptide binding]; other site
1125630005031	catalytic residues [active]
1125630005032	alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382
1125630005033	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1125630005034	dimer interface [polypeptide binding]; other site
1125630005035	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1125630005036	catalytic triad [active]
1125630005037	peroxidatic and resolving cysteines [active]
1125630005038	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
1125630005039	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
1125630005040	catalytic residue [active]
1125630005041	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
1125630005042	catalytic residues [active]
1125630005043	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1125630005044	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1125630005045	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1125630005046	Ligand Binding Site [chemical binding]; other site
1125630005047	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
1125630005048	Rnk N-terminus; Region: Rnk_N; pfam14760
1125630005049	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1125630005050	ribonuclease I; Provisional; Region: PRK10095
1125630005051	CAS motifs; other site
1125630005052	active site
1125630005053	C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654
1125630005054	C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069
1125630005055	phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045
1125630005056	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1125630005057	DNA-binding site [nucleotide binding]; DNA binding site
1125630005058	RNA-binding motif; other site
1125630005059	chromosome condensation membrane protein; Provisional; Region: PRK14196
1125630005060	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
1125630005061	putative active site [active]
1125630005062	catalytic triad [active]
1125630005063	putative dimer interface [polypeptide binding]; other site
1125630005064	twin arginine translocase protein E; Validated; Region: tatE; PRK03625
1125630005065	lipoyl synthase; Provisional; Region: PRK05481
1125630005066	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1125630005067	FeS/SAM binding site; other site
1125630005068	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482
1125630005069	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630005070	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1125630005071	dimerization interface [polypeptide binding]; other site
1125630005072	lipoate-protein ligase B; Provisional; Region: PRK14342
1125630005073	hypothetical protein; Provisional; Region: PRK04998
1125630005074	D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793
1125630005075	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1125630005076	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
1125630005077	rare lipoprotein A; Provisional; Region: PRK10672
1125630005078	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
1125630005079	Sporulation related domain; Region: SPOR; pfam05036
1125630005080	cell wall shape-determining protein; Provisional; Region: PRK10794
1125630005081	penicillin-binding protein 2; Provisional; Region: PRK10795
1125630005082	Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717
1125630005083	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1125630005084	rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246
1125630005085	ribosome-associated protein; Provisional; Region: PRK11538
1125630005086	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1125630005087	catalytic core [active]
1125630005088	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1125630005089	active site
1125630005090	(T/H)XGH motif; other site
1125630005091	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
1125630005092	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1125630005093	Processivity clamp loader gamma complex DNA pol III C-term; Region: DNA_pol3_delt_C; pfam14840
1125630005094	LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796
1125630005095	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1125630005096	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1125630005097	active site
1125630005098	HIGH motif; other site
1125630005099	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1125630005100	KMSKS motif; other site
1125630005101	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1125630005102	tRNA binding surface [nucleotide binding]; other site
1125630005103	hypothetical protein; Provisional; Region: PRK11032
1125630005104	haemagglutination activity domain; Region: Haemagg_act; pfam05860
1125630005105	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
1125630005106	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
1125630005107	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1125630005108	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1125630005109	Walker A/P-loop; other site
1125630005110	ATP binding site [chemical binding]; other site
1125630005111	Q-loop/lid; other site
1125630005112	ABC transporter signature motif; other site
1125630005113	Walker B; other site
1125630005114	D-loop; other site
1125630005115	H-loop/switch region; other site
1125630005116	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
1125630005117	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630005118	dimer interface [polypeptide binding]; other site
1125630005119	conserved gate region; other site
1125630005120	putative PBP binding loops; other site
1125630005121	ABC-ATPase subunit interface; other site
1125630005122	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
1125630005123	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630005124	dimer interface [polypeptide binding]; other site
1125630005125	conserved gate region; other site
1125630005126	putative PBP binding loops; other site
1125630005127	ABC-ATPase subunit interface; other site
1125630005128	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
1125630005129	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1125630005130	substrate binding pocket [chemical binding]; other site
1125630005131	membrane-bound complex binding site; other site
1125630005132	hinge residues; other site
1125630005133	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
1125630005134	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
1125630005135	putative active site [active]
1125630005136	catalytic triad [active]
1125630005137	putative dimer interface [polypeptide binding]; other site
1125630005138	magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094
1125630005139	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1125630005140	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1125630005141	Transporter associated domain; Region: CorC_HlyC; smart01091
1125630005142	metal-binding heat shock protein; Provisional; Region: PRK00016
1125630005143	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1125630005144	PhoH-like protein; Region: PhoH; pfam02562
1125630005145	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
1125630005146	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1125630005147	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1125630005148	FeS/SAM binding site; other site
1125630005149	TRAM domain; Region: TRAM; pfam01938
1125630005150	2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020
1125630005151	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
1125630005152	asparagine synthetase B; Provisional; Region: asnB; PRK09431
1125630005153	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
1125630005154	active site
1125630005155	dimer interface [polypeptide binding]; other site
1125630005156	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1125630005157	Ligand Binding Site [chemical binding]; other site
1125630005158	Molecular Tunnel; other site
1125630005159	UMP phosphatase; Provisional; Region: PRK10444
1125630005160	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1125630005161	active site
1125630005162	motif I; other site
1125630005163	motif II; other site
1125630005164	MarR family; Region: MarR_2; cl17246
1125630005165	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1125630005166	ROK family; Region: ROK; pfam00480
1125630005167	N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221
1125630005168	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
1125630005169	active site
1125630005170	dimer interface [polypeptide binding]; other site
1125630005171	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
1125630005172	active site
1125630005173	trimer interface [polypeptide binding]; other site
1125630005174	allosteric site; other site
1125630005175	active site lid [active]
1125630005176	hexamer (dimer of trimers) interface [polypeptide binding]; other site
1125630005177	PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255
1125630005178	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1125630005179	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1125630005180	active site turn [active]
1125630005181	phosphorylation site [posttranslational modification]
1125630005182	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
1125630005183	HPr interaction site; other site
1125630005184	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1125630005185	active site
1125630005186	phosphorylation site [posttranslational modification]
1125630005187	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
1125630005188	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
1125630005189	active site
1125630005190	HIGH motif; other site
1125630005191	KMSKS motif; other site
1125630005192	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
1125630005193	outer membrane porin, OprD family; Region: OprD; pfam03573
1125630005194	YbfN-like lipoprotein; Region: YbfN; pfam13982
1125630005195	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1125630005196	metal binding site 2 [ion binding]; metal-binding site
1125630005197	putative DNA binding helix; other site
1125630005198	metal binding site 1 [ion binding]; metal-binding site
1125630005199	dimer interface [polypeptide binding]; other site
1125630005200	structural Zn2+ binding site [ion binding]; other site
1125630005201	flavodoxin FldA; Validated; Region: PRK09267
1125630005202	LexA regulated protein; Provisional; Region: PRK11675
1125630005203	Putative lysophospholipase; Region: Hydrolase_4; cl19140
1125630005204	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1125630005205	replication initiation regulator SeqA; Provisional; Region: PRK11187
1125630005206	phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132
1125630005207	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
1125630005208	active site
1125630005209	substrate binding site [chemical binding]; other site
1125630005210	metal binding site [ion binding]; metal-binding site
1125630005211	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
1125630005212	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1125630005213	active site
1125630005214	phosphorylation site [posttranslational modification]
1125630005215	intermolecular recognition site; other site
1125630005216	dimerization interface [polypeptide binding]; other site
1125630005217	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1125630005218	DNA binding site [nucleotide binding]
1125630005219	sensor protein KdpD; Provisional; Region: PRK10490
1125630005220	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
1125630005221	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
1125630005222	Ligand Binding Site [chemical binding]; other site
1125630005223	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
1125630005224	GAF domain; Region: GAF_3; pfam13492
1125630005225	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1125630005226	dimer interface [polypeptide binding]; other site
1125630005227	phosphorylation site [posttranslational modification]
1125630005228	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1125630005229	ATP binding site [chemical binding]; other site
1125630005230	Mg2+ binding site [ion binding]; other site
1125630005231	G-X-G motif; other site
1125630005232	potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315
1125630005233	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
1125630005234	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1125630005235	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1125630005236	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
1125630005237	Protein of unknown function (DUF2517); Region: DUF2517; pfam10725
1125630005238	deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674
1125630005239	DNA photolyase; Region: DNA_photolyase; pfam00875
1125630005240	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
1125630005241	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
1125630005242	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630005243	putative substrate translocation pore; other site
1125630005244	metal-binding protein; Provisional; Region: PRK10799
1125630005245	Allophanate hydrolase subunit 1; Region: AHS1; cl19310
1125630005246	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
1125630005247	Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800
1125630005248	putative active site [active]
1125630005249	Protein of unknown function (DUF969); Region: DUF969; pfam06149
1125630005250	Protein of unknown function (DUF979); Region: DUF979; pfam06166
1125630005251	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
1125630005252	putative substrate binding pocket [chemical binding]; other site
1125630005253	AC domain interface; other site
1125630005254	catalytic triad [active]
1125630005255	AB domain interface; other site
1125630005256	interchain disulfide; other site
1125630005257	endonuclease VIII; Provisional; Region: PRK10445
1125630005258	N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965
1125630005259	DNA binding site [nucleotide binding]
1125630005260	catalytic residue [active]
1125630005261	putative catalytic residues [active]
1125630005262	H2TH interface [polypeptide binding]; other site
1125630005263	intercalation triad [nucleotide binding]; other site
1125630005264	substrate specificity determining residue; other site
1125630005265	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1125630005266	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1125630005267	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
1125630005268	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
1125630005269	dimer interface [polypeptide binding]; other site
1125630005270	active site
1125630005271	citrylCoA binding site [chemical binding]; other site
1125630005272	NADH binding [chemical binding]; other site
1125630005273	cationic pore residues; other site
1125630005274	oxalacetate/citrate binding site [chemical binding]; other site
1125630005275	coenzyme A binding site [chemical binding]; other site
1125630005276	catalytic triad [active]
1125630005277	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
1125630005278	SdhD (CybS) interface [polypeptide binding]; other site
1125630005279	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
1125630005280	SdhC subunit interface [polypeptide binding]; other site
1125630005281	proximal heme binding site [chemical binding]; other site
1125630005282	cardiolipin binding site; other site
1125630005283	Iron-sulfur protein interface; other site
1125630005284	proximal quinone binding site [chemical binding]; other site
1125630005285	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958
1125630005286	L-aspartate oxidase; Provisional; Region: PRK06175
1125630005287	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1125630005288	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
1125630005289	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1125630005290	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
1125630005291	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
1125630005292	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
1125630005293	TPP-binding site [chemical binding]; other site
1125630005294	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
1125630005295	dimer interface [polypeptide binding]; other site
1125630005296	PYR/PP interface [polypeptide binding]; other site
1125630005297	TPP binding site [chemical binding]; other site
1125630005298	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
1125630005299	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1125630005300	E3 interaction surface; other site
1125630005301	lipoyl attachment site [posttranslational modification]; other site
1125630005302	e3 binding domain; Region: E3_binding; pfam02817
1125630005303	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1125630005304	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
1125630005305	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
1125630005306	CoA-ligase; Region: Ligase_CoA; pfam00549
1125630005307	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
1125630005308	CoA binding domain; Region: CoA_binding; pfam02629
1125630005309	CoA-ligase; Region: Ligase_CoA; pfam00549
1125630005310	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
1125630005311	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003
1125630005312	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
1125630005313	Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039
1125630005314	hypothetical protein; Provisional; Region: PRK10588
1125630005315	colicin uptake protein TolQ; Provisional; Region: PRK10801
1125630005316	colicin uptake protein TolR; Provisional; Region: PRK11024
1125630005317	cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510
1125630005318	TolA C-terminal; Region: TolA; pfam06519
1125630005319	translocation protein TolB; Provisional; Region: tolB; PRK03629
1125630005320	TolB amino-terminal domain; Region: TolB_N; pfam04052
1125630005321	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1125630005322	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1125630005323	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1125630005324	peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802
1125630005325	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1125630005326	ligand binding site [chemical binding]; other site
1125630005327	tol-pal system protein YbgF; Provisional; Region: PRK10803
1125630005328	Tetratricopeptide repeat; Region: TPR_6; pfam13174
1125630005329	Tetratricopeptide repeat; Region: TPR_6; pfam13174
1125630005330	quinolinate synthetase; Provisional; Region: PRK09375
1125630005331	nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397
1125630005332	zinc transporter ZitB; Provisional; Region: PRK03557
1125630005333	YbgS-like protein; Region: YbgS; pfam13985
1125630005334	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
1125630005335	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1125630005336	catalytic core [active]
1125630005337	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
1125630005338	active site
1125630005339	catalytic residues [active]
1125630005340	galactokinase; Provisional; Region: PRK05101
1125630005341	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
1125630005342	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1125630005343	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1125630005344	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720
1125630005345	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
1125630005346	dimer interface [polypeptide binding]; other site
1125630005347	active site
1125630005348	UDP-galactose-4-epimerase; Provisional; Region: PRK10675
1125630005349	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1125630005350	NAD binding site [chemical binding]; other site
1125630005351	homodimer interface [polypeptide binding]; other site
1125630005352	active site
1125630005353	substrate binding site [chemical binding]; other site
1125630005354	potential frameshift: common BLAST hit: gi|152969331|ref|YP_001334440.1| putative molybdenum transport ATP-binding protein ModF
1125630005355	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1125630005356	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
1125630005357	Walker A/P-loop; other site
1125630005358	ATP binding site [chemical binding]; other site
1125630005359	Q-loop/lid; other site
1125630005360	ABC transporter signature motif; other site
1125630005361	Walker B; other site
1125630005362	D-loop; other site
1125630005363	H-loop/switch region; other site
1125630005364	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1125630005365	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1125630005366	Walker A/P-loop; other site
1125630005367	ATP binding site [chemical binding]; other site
1125630005368	Q-loop/lid; other site
1125630005369	ABC transporter signature motif; other site
1125630005370	Walker B; other site
1125630005371	D-loop; other site
1125630005372	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
1125630005373	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
1125630005374	molybdenum-pterin binding domain; Region: Mop; TIGR00638
1125630005375	TOBE domain; Region: TOBE; pfam03459
1125630005376	Protein of unknown function (DUF2592); Region: DUF2592; pfam10766
1125630005377	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1125630005378	substrate binding pocket [chemical binding]; other site
1125630005379	membrane-bound complex binding site; other site
1125630005380	hinge residues; other site
1125630005381	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1125630005382	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630005383	dimer interface [polypeptide binding]; other site
1125630005384	conserved gate region; other site
1125630005385	putative PBP binding loops; other site
1125630005386	ABC-ATPase subunit interface; other site
1125630005387	molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144
1125630005388	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1125630005389	Walker A/P-loop; other site
1125630005390	ATP binding site [chemical binding]; other site
1125630005391	Q-loop/lid; other site
1125630005392	ABC transporter signature motif; other site
1125630005393	Walker B; other site
1125630005394	D-loop; other site
1125630005395	H-loop/switch region; other site
1125630005396	TOBE domain; Region: TOBE; cl01440
1125630005397	pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530
1125630005398	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1125630005399	active site
1125630005400	motif I; other site
1125630005401	motif II; other site
1125630005402	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
1125630005403	6-phosphogluconolactonase; Provisional; Region: PRK11028
1125630005404	Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798
1125630005405	Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798
1125630005406	Sensors of blue-light using FAD; Region: BLUF; smart01034
1125630005407	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1125630005408	transcriptional regulator MirA; Provisional; Region: PRK15043
1125630005409	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
1125630005410	DNA binding residues [nucleotide binding]
1125630005411	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1125630005412	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
1125630005413	DNA binding residues [nucleotide binding]
1125630005414	dimerization interface [polypeptide binding]; other site
1125630005415	Putative biofilm-dependent modulation protein; Region: BDM; cl11581
1125630005416	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
1125630005417	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1125630005418	acyl-CoA thioesterase; Provisional; Region: PRK10531
1125630005419	Pectinesterase; Region: Pectinesterase; cl01911
1125630005420	imidazolonepropionase; Validated; Region: PRK09356
1125630005421	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
1125630005422	active site
1125630005423	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
1125630005424	putative active site [active]
1125630005425	putative metal binding site [ion binding]; other site
1125630005426	histidine utilization repressor; Provisional; Region: PRK14999
1125630005427	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1125630005428	DNA-binding site [nucleotide binding]; DNA binding site
1125630005429	UTRA domain; Region: UTRA; pfam07702
1125630005430	potential frameshift: common BLAST hit: gi|336249366|ref|YP_004593076.1| urocanate hydratase
1125630005431	Urocanase; Region: Urocanase; cl19311
1125630005432	Urocanase; Region: Urocanase; cl19311
1125630005433	Aromatic amino acid lyase; Region: Lyase_aromatic; pfam00221
1125630005434	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
1125630005435	active sites [active]
1125630005436	tetramer interface [polypeptide binding]; other site
1125630005437	putative proline-specific permease; Provisional; Region: proY; PRK10580
1125630005438	Spore germination protein; Region: Spore_permease; cl17796
1125630005439	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1125630005440	substrate binding site [chemical binding]; other site
1125630005441	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
1125630005442	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1125630005443	inhibitor-cofactor binding pocket; inhibition site
1125630005444	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630005445	catalytic residue [active]
1125630005446	biotin synthase; Provisional; Region: PRK15108
1125630005447	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1125630005448	FeS/SAM binding site; other site
1125630005449	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
1125630005450	8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858
1125630005451	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
1125630005452	substrate-cofactor binding pocket; other site
1125630005453	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630005454	catalytic residue [active]
1125630005455	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
1125630005456	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1125630005457	S-adenosylmethionine binding site [chemical binding]; other site
1125630005458	AAA domain; Region: AAA_26; pfam13500
1125630005459	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
1125630005460	excinuclease ABC subunit B; Provisional; Region: PRK05298
1125630005461	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1125630005462	ATP binding site [chemical binding]; other site
1125630005463	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1125630005464	nucleotide binding region [chemical binding]; other site
1125630005465	ATP-binding site [chemical binding]; other site
1125630005466	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1125630005467	UvrB/uvrC motif; Region: UVR; pfam02151
1125630005468	sensor protein BasS/PmrB; Provisional; Region: PRK10755
1125630005469	HAMP domain; Region: HAMP; pfam00672
1125630005470	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1125630005471	dimer interface [polypeptide binding]; other site
1125630005472	phosphorylation site [posttranslational modification]
1125630005473	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1125630005474	ATP binding site [chemical binding]; other site
1125630005475	Mg2+ binding site [ion binding]; other site
1125630005476	G-X-G motif; other site
1125630005477	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
1125630005478	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1125630005479	active site
1125630005480	phosphorylation site [posttranslational modification]
1125630005481	intermolecular recognition site; other site
1125630005482	dimerization interface [polypeptide binding]; other site
1125630005483	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1125630005484	DNA binding site [nucleotide binding]
1125630005485	putative metal dependent hydrolase; Provisional; Region: PRK11598
1125630005486	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
1125630005487	Sulfatase; Region: Sulfatase; pfam00884
1125630005488	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
1125630005489	phosphate binding site [ion binding]; other site
1125630005490	putative substrate binding pocket [chemical binding]; other site
1125630005491	dimer interface [polypeptide binding]; other site
1125630005492	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
1125630005493	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1125630005494	FeS/SAM binding site; other site
1125630005495	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1125630005496	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1125630005497	MPT binding site; other site
1125630005498	trimer interface [polypeptide binding]; other site
1125630005499	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
1125630005500	trimer interface [polypeptide binding]; other site
1125630005501	dimer interface [polypeptide binding]; other site
1125630005502	putative active site [active]
1125630005503	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
1125630005504	MoaE interaction surface [polypeptide binding]; other site
1125630005505	MoeB interaction surface [polypeptide binding]; other site
1125630005506	thiocarboxylated glycine; other site
1125630005507	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
1125630005508	MoaE homodimer interface [polypeptide binding]; other site
1125630005509	MoaD interaction [polypeptide binding]; other site
1125630005510	active site residues [active]
1125630005511	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
1125630005512	Predicted integral membrane protein [Function unknown]; Region: COG0392
1125630005513	cardiolipin synthase 2; Provisional; Region: PRK11263
1125630005514	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1125630005515	putative active site [active]
1125630005516	catalytic site [active]
1125630005517	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
1125630005518	putative active site [active]
1125630005519	catalytic site [active]
1125630005520	Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568
1125630005521	putative catalytic site [active]
1125630005522	putative metal binding site [ion binding]; other site
1125630005523	putative phosphate binding site [ion binding]; other site
1125630005524	Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076
1125630005525	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1125630005526	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1125630005527	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1125630005528	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
1125630005529	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1125630005530	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1125630005531	Walker A/P-loop; other site
1125630005532	ATP binding site [chemical binding]; other site
1125630005533	Q-loop/lid; other site
1125630005534	ABC transporter signature motif; other site
1125630005535	Walker B; other site
1125630005536	D-loop; other site
1125630005537	H-loop/switch region; other site
1125630005538	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1125630005539	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1125630005540	Walker A/P-loop; other site
1125630005541	ATP binding site [chemical binding]; other site
1125630005542	Q-loop/lid; other site
1125630005543	ABC transporter signature motif; other site
1125630005544	Walker B; other site
1125630005545	D-loop; other site
1125630005546	H-loop/switch region; other site
1125630005547	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
1125630005548	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1125630005549	HlyD family secretion protein; Region: HlyD_3; pfam13437
1125630005550	potential frameshift: common BLAST hit: gi|238893846|ref|YP_002918580.1| putative DNA-binding transcriptional regulator
1125630005551	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
1125630005552	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1125630005553	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1125630005554	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630005555	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1125630005556	dimerization interface [polypeptide binding]; other site
1125630005557	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630005558	D-galactonate transporter; Region: 2A0114; TIGR00893
1125630005559	putative substrate translocation pore; other site
1125630005560	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1125630005561	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1125630005562	NAD(P) binding site [chemical binding]; other site
1125630005563	active site
1125630005564	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1125630005565	TPP-binding site [chemical binding]; other site
1125630005566	dimer interface [polypeptide binding]; other site
1125630005567	potential frameshift: common BLAST hit: gi|238893852|ref|YP_002918586.1| putative transketolase
1125630005568	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
1125630005569	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1125630005570	PYR/PP interface [polypeptide binding]; other site
1125630005571	dimer interface [polypeptide binding]; other site
1125630005572	TPP binding site [chemical binding]; other site
1125630005573	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1125630005574	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
1125630005575	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1125630005576	ATP binding site [chemical binding]; other site
1125630005577	Mg++ binding site [ion binding]; other site
1125630005578	motif III; other site
1125630005579	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1125630005580	nucleotide binding region [chemical binding]; other site
1125630005581	ATP-binding site [chemical binding]; other site
1125630005582	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
1125630005583	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1125630005584	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1125630005585	glycosyl transferase family protein; Provisional; Region: PRK08136
1125630005586	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1125630005587	Protein of unknown function (DUF1471); Region: DUF1471; cl11507
1125630005588	hypothetical protein; Provisional; Region: PRK11019
1125630005589	Protein of unknown function (DUF1471); Region: DUF1471; cl11507
1125630005590	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1125630005591	potential frameshift: common BLAST hit: gi|152969393|ref|YP_001334502.1| putative SAM-dependent methyltransferase
1125630005592	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1125630005593	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1125630005594	putative mechanosensitive channel protein; Provisional; Region: PRK11465
1125630005595	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1125630005596	glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493
1125630005597	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1125630005598	Walker A/P-loop; other site
1125630005599	ATP binding site [chemical binding]; other site
1125630005600	Q-loop/lid; other site
1125630005601	ABC transporter signature motif; other site
1125630005602	Walker B; other site
1125630005603	D-loop; other site
1125630005604	H-loop/switch region; other site
1125630005605	glutamine ABC transporter permease protein; Reviewed; Region: glnP; PRK09494
1125630005606	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630005607	dimer interface [polypeptide binding]; other site
1125630005608	conserved gate region; other site
1125630005609	putative PBP binding loops; other site
1125630005610	ABC-ATPase subunit interface; other site
1125630005611	glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495
1125630005612	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1125630005613	substrate binding pocket [chemical binding]; other site
1125630005614	membrane-bound complex binding site; other site
1125630005615	hinge residues; other site
1125630005616	Ferritin-like domain; Region: Ferritin; pfam00210
1125630005617	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1125630005618	dimerization interface [polypeptide binding]; other site
1125630005619	DPS ferroxidase diiron center [ion binding]; other site
1125630005620	ion pore; other site
1125630005621	threonine and homoserine efflux system; Provisional; Region: PRK10532
1125630005622	EamA-like transporter family; Region: EamA; pfam00892
1125630005623	outer membrane protein X; Provisional; Region: ompX; PRK09408
1125630005624	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
1125630005625	Sulfatase; Region: Sulfatase; pfam00884
1125630005626	manganese transport regulator MntR; Provisional; Region: PRK11050
1125630005627	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
1125630005628	Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742
1125630005629	Putative anion permease YbiR.  Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117
1125630005630	transmembrane helices; other site
1125630005631	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1125630005632	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232
1125630005633	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
1125630005634	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1125630005635	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1125630005636	DNA-binding site [nucleotide binding]; DNA binding site
1125630005637	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1125630005638	L,D-transpeptidase; Provisional; Region: PRK10260
1125630005639	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1125630005640	Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365
1125630005641	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
1125630005642	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
1125630005643	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
1125630005644	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1125630005645	ABC transporter; Region: ABC_tran_2; pfam12848
1125630005646	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1125630005647	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
1125630005648	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
1125630005649	Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599
1125630005650	putative active site [active]
1125630005651	putative catalytic site [active]
1125630005652	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630005653	D-galactonate transporter; Region: 2A0114; TIGR00893
1125630005654	putative substrate translocation pore; other site
1125630005655	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1125630005656	DNA binding site [nucleotide binding]
1125630005657	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1125630005658	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1125630005659	ligand binding site [chemical binding]; other site
1125630005660	dimerization interface [polypeptide binding]; other site
1125630005661	Protein of unknown function (DUF1479); Region: DUF1479; pfam07350
1125630005662	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
1125630005663	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1125630005664	active site
1125630005665	motif I; other site
1125630005666	motif II; other site
1125630005667	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
1125630005668	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
1125630005669	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
1125630005670	dimer interface [polypeptide binding]; other site
1125630005671	active site
1125630005672	glycine loop; other site
1125630005673	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
1125630005674	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
1125630005675	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1125630005676	FeS/SAM binding site; other site
1125630005677	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
1125630005678	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1125630005679	ATP binding site [chemical binding]; other site
1125630005680	substrate interface [chemical binding]; other site
1125630005681	molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680
1125630005682	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1125630005683	dimer interface [polypeptide binding]; other site
1125630005684	putative functional site; other site
1125630005685	putative MPT binding site; other site
1125630005686	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
1125630005687	catalytic nucleophile [active]
1125630005688	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
1125630005689	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1125630005690	Walker A/P-loop; other site
1125630005691	ATP binding site [chemical binding]; other site
1125630005692	Q-loop/lid; other site
1125630005693	ABC transporter signature motif; other site
1125630005694	Walker B; other site
1125630005695	D-loop; other site
1125630005696	H-loop/switch region; other site
1125630005697	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1125630005698	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1125630005699	Walker A/P-loop; other site
1125630005700	ATP binding site [chemical binding]; other site
1125630005701	Q-loop/lid; other site
1125630005702	ABC transporter signature motif; other site
1125630005703	Walker B; other site
1125630005704	D-loop; other site
1125630005705	H-loop/switch region; other site
1125630005706	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1125630005707	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1125630005708	The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499
1125630005709	glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081
1125630005710	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630005711	dimer interface [polypeptide binding]; other site
1125630005712	conserved gate region; other site
1125630005713	putative PBP binding loops; other site
1125630005714	ABC-ATPase subunit interface; other site
1125630005715	glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082
1125630005716	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1125630005717	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630005718	dimer interface [polypeptide binding]; other site
1125630005719	conserved gate region; other site
1125630005720	putative PBP binding loops; other site
1125630005721	ABC-ATPase subunit interface; other site
1125630005722	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
1125630005723	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1125630005724	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1125630005725	FeS/SAM binding site; other site
1125630005726	galactoside permease; Reviewed; Region: lacY; PRK09528
1125630005727	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630005728	putative substrate translocation pore; other site
1125630005729	biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302
1125630005730	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645
1125630005731	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
1125630005732	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1125630005733	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
1125630005734	putative C-terminal domain interface [polypeptide binding]; other site
1125630005735	putative GSH binding site (G-site) [chemical binding]; other site
1125630005736	putative dimer interface [polypeptide binding]; other site
1125630005737	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
1125630005738	N-terminal domain interface [polypeptide binding]; other site
1125630005739	dimer interface [polypeptide binding]; other site
1125630005740	substrate binding pocket (H-site) [chemical binding]; other site
1125630005741	D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001
1125630005742	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1125630005743	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
1125630005744	DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681
1125630005745	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
1125630005746	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1125630005747	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1125630005748	PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385
1125630005749	active site
1125630005750	multidrug efflux system translocase MdfA; Provisional; Region: PRK15402
1125630005751	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630005752	putative substrate translocation pore; other site
1125630005753	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1125630005754	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1125630005755	active site
1125630005756	motif I; other site
1125630005757	motif II; other site
1125630005758	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1125630005759	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
1125630005760	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
1125630005761	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630005762	putative substrate translocation pore; other site
1125630005763	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
1125630005764	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1125630005765	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1125630005766	integrase; Provisional; Region: int; PHA02601
1125630005767	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1125630005768	active site
1125630005769	DNA binding site [nucleotide binding]
1125630005770	Int/Topo IB signature motif; other site
1125630005771	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1125630005772	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1125630005773	putative active site [active]
1125630005774	putative NTP binding site [chemical binding]; other site
1125630005775	putative nucleic acid binding site [nucleotide binding]; other site
1125630005776	DinI-like family; Region: DinI; pfam06183
1125630005777	AIPR protein; Region: AIPR; pfam10592
1125630005778	portal vertex protein; Provisional; Region: Q; PHA02536
1125630005779	terminase ATPase subunit; Provisional; Region: P; PHA02535
1125630005780	Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056
1125630005781	Phage Terminase; Region: Terminase_1; cl19862
1125630005782	Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; pfam05929
1125630005783	capsid protein; Provisional; Region: N; PHA02538
1125630005784	terminase endonuclease subunit; Provisional; Region: M; PHA02537
1125630005785	Phage head completion protein (GPL); Region: Phage_GPL; pfam05926
1125630005786	P2-like prophage tail protein X [General function prediction only]; Region: COG5004
1125630005787	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
1125630005788	catalytic residues [active]
1125630005789	phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495
1125630005790	P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891
1125630005791	Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069
1125630005792	Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540
1125630005793	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
1125630005794	baseplate assembly protein; Provisional; Region: J; PHA02568
1125630005795	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817
1125630005796	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
1125630005797	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
1125630005798	major tail sheath protein; Provisional; Region: FI; PHA02560
1125630005799	major tail tube protein; Provisional; Region: FII; PHA02600
1125630005800	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
1125630005801	Phage P2 GpE; Region: Phage_P2_GpE; pfam06528
1125630005802	Phage-related tail protein [Function unknown]; Region: COG5283
1125630005803	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050
1125630005804	Phage protein U [General function prediction only]; Region: COG3499
1125630005805	tail protein; Provisional; Region: D; PHA02561
1125630005806	Ogr/Delta-like zinc finger; Region: Ogr_Delta; cl19592
1125630005807	potential frameshift: common BLAST hit: gi|288936352|ref|YP_003440411.1| YidE/YbjL protein
1125630005808	Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061
1125630005809	TrkA-C domain; Region: TrkA_C; pfam02080
1125630005810	TrkA-C domain; Region: TrkA_C; pfam02080
1125630005811	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
1125630005812	Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061
1125630005813	Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045
1125630005814	Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066
1125630005815	GSH binding site [chemical binding]; other site
1125630005816	catalytic residues [active]
1125630005817	Protein of unknown function (DUF1418); Region: DUF1418; pfam07214
1125630005818	potential frameshift: common BLAST hit: gi|288936348|ref|YP_003440407.1| nitroreductase
1125630005819	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
1125630005820	FMN binding site [chemical binding]; other site
1125630005821	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
1125630005822	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
1125630005823	RimK-like ATP-grasp domain; Region: RimK; pfam08443
1125630005824	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
1125630005825	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
1125630005826	putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607
1125630005827	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1125630005828	Walker A/P-loop; other site
1125630005829	ATP binding site [chemical binding]; other site
1125630005830	Q-loop/lid; other site
1125630005831	ABC transporter signature motif; other site
1125630005832	Walker B; other site
1125630005833	D-loop; other site
1125630005834	H-loop/switch region; other site
1125630005835	TOBE domain; Region: TOBE_2; pfam08402
1125630005836	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1125630005837	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630005838	dimer interface [polypeptide binding]; other site
1125630005839	conserved gate region; other site
1125630005840	putative PBP binding loops; other site
1125630005841	ABC-ATPase subunit interface; other site
1125630005842	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1125630005843	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630005844	dimer interface [polypeptide binding]; other site
1125630005845	conserved gate region; other site
1125630005846	putative PBP binding loops; other site
1125630005847	ABC-ATPase subunit interface; other site
1125630005848	Protein of unknown function (DUF2593); Region: DUF2593; pfam10767
1125630005849	23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085
1125630005850	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1125630005851	S-adenosylmethionine binding site [chemical binding]; other site
1125630005852	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1125630005853	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1125630005854	active site
1125630005855	phosphorylation site [posttranslational modification]
1125630005856	intermolecular recognition site; other site
1125630005857	dimerization interface [polypeptide binding]; other site
1125630005858	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1125630005859	DNA binding site [nucleotide binding]
1125630005860	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
1125630005861	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1125630005862	dimer interface [polypeptide binding]; other site
1125630005863	phosphorylation site [posttranslational modification]
1125630005864	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1125630005865	ATP binding site [chemical binding]; other site
1125630005866	Mg2+ binding site [ion binding]; other site
1125630005867	G-X-G motif; other site
1125630005868	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
1125630005869	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1125630005870	substrate binding pocket [chemical binding]; other site
1125630005871	membrane-bound complex binding site; other site
1125630005872	hinge residues; other site
1125630005873	arginine transporter permease subunit ArtM; Provisional; Region: artM; PRK11122
1125630005874	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630005875	dimer interface [polypeptide binding]; other site
1125630005876	conserved gate region; other site
1125630005877	putative PBP binding loops; other site
1125630005878	ABC-ATPase subunit interface; other site
1125630005879	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1125630005880	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630005881	dimer interface [polypeptide binding]; other site
1125630005882	conserved gate region; other site
1125630005883	putative PBP binding loops; other site
1125630005884	ABC-ATPase subunit interface; other site
1125630005885	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
1125630005886	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1125630005887	substrate binding pocket [chemical binding]; other site
1125630005888	membrane-bound complex binding site; other site
1125630005889	hinge residues; other site
1125630005890	arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124
1125630005891	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1125630005892	Walker A/P-loop; other site
1125630005893	ATP binding site [chemical binding]; other site
1125630005894	Q-loop/lid; other site
1125630005895	ABC transporter signature motif; other site
1125630005896	Walker B; other site
1125630005897	D-loop; other site
1125630005898	H-loop/switch region; other site
1125630005899	putative lipoprotein; Provisional; Region: PRK10533
1125630005900	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1125630005901	metal binding site [ion binding]; metal-binding site
1125630005902	active site
1125630005903	I-site; other site
1125630005904	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
1125630005905	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1125630005906	amidase catalytic site [active]
1125630005907	Zn binding residues [ion binding]; other site
1125630005908	substrate binding site [chemical binding]; other site
1125630005909	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1125630005910	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1125630005911	NAD(P) binding site [chemical binding]; other site
1125630005912	active site
1125630005913	atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245
1125630005914	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1125630005915	putative NAD(P) binding site [chemical binding]; other site
1125630005916	putative active site [active]
1125630005917	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
1125630005918	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
1125630005919	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
1125630005920	tetramer interface [polypeptide binding]; other site
1125630005921	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630005922	catalytic residue [active]
1125630005923	pyruvate dehydrogenase; Provisional; Region: PRK09124
1125630005924	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
1125630005925	PYR/PP interface [polypeptide binding]; other site
1125630005926	dimer interface [polypeptide binding]; other site
1125630005927	tetramer interface [polypeptide binding]; other site
1125630005928	TPP binding site [chemical binding]; other site
1125630005929	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1125630005930	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
1125630005931	TPP-binding site [chemical binding]; other site
1125630005932	Predicted membrane protein [Function unknown]; Region: COG2259
1125630005933	HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684
1125630005934	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
1125630005935	FAD binding pocket [chemical binding]; other site
1125630005936	FAD binding motif [chemical binding]; other site
1125630005937	phosphate binding motif [ion binding]; other site
1125630005938	beta-alpha-beta structure motif; other site
1125630005939	NAD binding pocket [chemical binding]; other site
1125630005940	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1125630005941	catalytic loop [active]
1125630005942	iron binding site [ion binding]; other site
1125630005943	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
1125630005944	cubane metal cluster [ion binding]; other site
1125630005945	hybrid metal cluster; other site
1125630005946	Predicted membrane protein [Function unknown]; Region: COG2431
1125630005947	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
1125630005948	amphipathic channel; other site
1125630005949	Asn-Pro-Ala signature motifs; other site
1125630005950	potential frameshift: common BLAST hit: gi|238893939|ref|YP_002918673.1| putative ATP-dependent endonuclease
1125630005951	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
1125630005952	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
1125630005953	AAA domain; Region: AAA_21; pfam13304
1125630005954	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
1125630005955	putative active site [active]
1125630005956	putative metal-binding site [ion binding]; other site
1125630005957	macrolide transporter subunit MacA; Provisional; Region: PRK11578
1125630005958	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1125630005959	HlyD family secretion protein; Region: HlyD_3; pfam13437
1125630005960	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
1125630005961	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1125630005962	Walker A/P-loop; other site
1125630005963	ATP binding site [chemical binding]; other site
1125630005964	Q-loop/lid; other site
1125630005965	ABC transporter signature motif; other site
1125630005966	Walker B; other site
1125630005967	D-loop; other site
1125630005968	H-loop/switch region; other site
1125630005969	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1125630005970	FtsX-like permease family; Region: FtsX; pfam02687
1125630005971	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1125630005972	DNA-binding site [nucleotide binding]; DNA binding site
1125630005973	RNA-binding motif; other site
1125630005974	Uncharacterized conserved protein [Function unknown]; Region: COG2127
1125630005975	ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034
1125630005976	Clp amino terminal domain; Region: Clp_N; pfam02861
1125630005977	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1125630005978	Walker A motif; other site
1125630005979	ATP binding site [chemical binding]; other site
1125630005980	Walker B motif; other site
1125630005981	arginine finger; other site
1125630005982	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1125630005983	Walker A motif; other site
1125630005984	ATP binding site [chemical binding]; other site
1125630005985	Walker B motif; other site
1125630005986	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1125630005987	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1125630005988	rRNA binding site [nucleotide binding]; other site
1125630005989	predicted 30S ribosome binding site; other site
1125630005990	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
1125630005991	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160
1125630005992	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1125630005993	ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247
1125630005994	Walker A/P-loop; other site
1125630005995	ATP binding site [chemical binding]; other site
1125630005996	Q-loop/lid; other site
1125630005997	ABC transporter signature motif; other site
1125630005998	Walker B; other site
1125630005999	D-loop; other site
1125630006000	H-loop/switch region; other site
1125630006001	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174
1125630006002	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1125630006003	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1125630006004	Walker A/P-loop; other site
1125630006005	ATP binding site [chemical binding]; other site
1125630006006	Q-loop/lid; other site
1125630006007	ABC transporter signature motif; other site
1125630006008	Walker B; other site
1125630006009	D-loop; other site
1125630006010	H-loop/switch region; other site
1125630006011	thioredoxin reductase; Provisional; Region: PRK10262
1125630006012	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1125630006013	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1125630006014	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
1125630006015	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1125630006016	putative DNA binding site [nucleotide binding]; other site
1125630006017	putative Zn2+ binding site [ion binding]; other site
1125630006018	AsnC family; Region: AsnC_trans_reg; pfam01037
1125630006019	DNA translocase FtsK; Provisional; Region: PRK10263
1125630006020	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630006021	hypothetical protein; Provisional; Region: PHA03160
1125630006022	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
1125630006023	YppG-like protein; Region: YppG; pfam14179
1125630006024	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1125630006025	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1125630006026	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1125630006027	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl19192
1125630006028	recombination factor protein RarA; Reviewed; Region: PRK13342
1125630006029	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1125630006030	Walker A motif; other site
1125630006031	ATP binding site [chemical binding]; other site
1125630006032	Walker B motif; other site
1125630006033	arginine finger; other site
1125630006034	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1125630006035	seryl-tRNA synthetase; Provisional; Region: PRK05431
1125630006036	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1125630006037	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1125630006038	dimer interface [polypeptide binding]; other site
1125630006039	active site
1125630006040	motif 1; other site
1125630006041	motif 2; other site
1125630006042	motif 3; other site
1125630006043	anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990
1125630006044	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
1125630006045	putative [Fe4-S4] binding site [ion binding]; other site
1125630006046	putative molybdopterin cofactor binding site [chemical binding]; other site
1125630006047	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
1125630006048	putative molybdopterin cofactor binding site; other site
1125630006049	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
1125630006050	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
1125630006051	DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976
1125630006052	putative MFS family transporter protein; Provisional; Region: PRK03633
1125630006053	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630006054	putative substrate translocation pore; other site
1125630006055	pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145
1125630006056	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1125630006057	FeS/SAM binding site; other site
1125630006058	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
1125630006059	Pyruvate formate lyase 1; Region: PFL1; cd01678
1125630006060	coenzyme A binding site [chemical binding]; other site
1125630006061	active site
1125630006062	catalytic residues [active]
1125630006063	glycine loop; other site
1125630006064	formate transporter; Provisional; Region: PRK10805
1125630006065	uncharacterized domain; Region: TIGR00702
1125630006066	Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561
1125630006067	Predicted membrane protein [Function unknown]; Region: COG2323
1125630006068	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
1125630006069	homodimer interface [polypeptide binding]; other site
1125630006070	substrate-cofactor binding pocket; other site
1125630006071	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630006072	catalytic residue [active]
1125630006073	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
1125630006074	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1125630006075	hinge; other site
1125630006076	active site
1125630006077	cytidylate kinase; Provisional; Region: cmk; PRK00023
1125630006078	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1125630006079	CMP-binding site; other site
1125630006080	The sites determining sugar specificity; other site
1125630006081	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
1125630006082	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1125630006083	RNA binding site [nucleotide binding]; other site
1125630006084	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1125630006085	RNA binding site [nucleotide binding]; other site
1125630006086	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
1125630006087	RNA binding site [nucleotide binding]; other site
1125630006088	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1125630006089	RNA binding site [nucleotide binding]; other site
1125630006090	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
1125630006091	RNA binding site [nucleotide binding]; other site
1125630006092	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
1125630006093	RNA binding site [nucleotide binding]; other site
1125630006094	Beta subunit of integration host factor (IHFB); Region: IHF_B; cd13836
1125630006095	dimer interface [polypeptide binding]; other site
1125630006096	DNA binding site [nucleotide binding]
1125630006097	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
1125630006098	ComEC family competence protein; Provisional; Region: PRK11539
1125630006099	Competence protein; Region: Competence; pfam03772
1125630006100	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1125630006101	lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176
1125630006102	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1125630006103	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1125630006104	Walker A/P-loop; other site
1125630006105	ATP binding site [chemical binding]; other site
1125630006106	Q-loop/lid; other site
1125630006107	ABC transporter signature motif; other site
1125630006108	Walker B; other site
1125630006109	D-loop; other site
1125630006110	H-loop/switch region; other site
1125630006111	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
1125630006112	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
1125630006113	Trm112p-like protein; Region: Trm112p; cl01066
1125630006114	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
1125630006115	Ligand binding site; other site
1125630006116	oligomer interface; other site
1125630006117	hypothetical protein; Provisional; Region: PRK10593
1125630006118	Phosphotransferase enzyme family; Region: APH; pfam01636
1125630006119	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1125630006120	putative active site [active]
1125630006121	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1125630006122	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1125630006123	S-adenosylmethionine binding site [chemical binding]; other site
1125630006124	potential frameshift: common BLAST hit: gi|238893978|ref|YP_002918712.1| condesin subunit F
1125630006125	KicB killing factor; Region: KicB; cl11468
1125630006126	condesin subunit F; Provisional; Region: PRK05260
1125630006127	condesin subunit E; Provisional; Region: PRK05256
1125630006128	Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096
1125630006129	P-loop containing region of AAA domain; Region: AAA_29; cl17516
1125630006130	HemX; Region: HemX; cl19375
1125630006131	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
1125630006132	murein L,D-transpeptidase; Provisional; Region: PRK10594
1125630006133	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1125630006134	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1125630006135	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1125630006136	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
1125630006137	Peptidase M15; Region: Peptidase_M15_3; cl01194
1125630006138	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1125630006139	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
1125630006140	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1125630006141	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630006142	homodimer interface [polypeptide binding]; other site
1125630006143	catalytic residue [active]
1125630006144	potential frameshift: common BLAST hit: gi|238893985|ref|YP_002918719.1| outer membrane protein 1A/OmpK35 porin
1125630006145	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1125630006146	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1125630006147	potential frameshift: common BLAST hit: gi|238893987|ref|YP_002918721.1| asparaginyl-tRNA synthetase
1125630006148	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
1125630006149	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1125630006150	active site
1125630006151	dimer interface [polypeptide binding]; other site
1125630006152	motif 2; other site
1125630006153	motif 3; other site
1125630006154	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
1125630006155	putative anticodon binding site; other site
1125630006156	putative dimer interface [polypeptide binding]; other site
1125630006157	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1125630006158	motif 1; other site
1125630006159	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1125630006160	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1125630006161	dimerization interface [polypeptide binding]; other site
1125630006162	putative DNA binding site [nucleotide binding]; other site
1125630006163	putative Zn2+ binding site [ion binding]; other site
1125630006164	AsnC family; Region: AsnC_trans_reg; pfam01037
1125630006165	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640
1125630006166	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1125630006167	catalytic residue [active]
1125630006168	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
1125630006169	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
1125630006170	allantoate amidohydrolase; Reviewed; Region: PRK12893
1125630006171	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
1125630006172	active site
1125630006173	metal binding site [ion binding]; metal-binding site
1125630006174	dimer interface [polypeptide binding]; other site
1125630006175	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1125630006176	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
1125630006177	metal binding site [ion binding]; metal-binding site
1125630006178	putative dimer interface [polypeptide binding]; other site
1125630006179	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
1125630006180	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
1125630006181	active site
1125630006182	aminopeptidase N; Provisional; Region: pepN; PRK14015
1125630006183	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
1125630006184	active site
1125630006185	Zn binding site [ion binding]; other site
1125630006186	aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247
1125630006187	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1125630006188	Walker A/P-loop; other site
1125630006189	ATP binding site [chemical binding]; other site
1125630006190	Q-loop/lid; other site
1125630006191	ABC transporter signature motif; other site
1125630006192	Walker B; other site
1125630006193	D-loop; other site
1125630006194	H-loop/switch region; other site
1125630006195	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1125630006196	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630006197	dimer interface [polypeptide binding]; other site
1125630006198	conserved gate region; other site
1125630006199	putative PBP binding loops; other site
1125630006200	ABC-ATPase subunit interface; other site
1125630006201	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
1125630006202	active site
1125630006203	dimer interface [polypeptide binding]; other site
1125630006204	non-prolyl cis peptide bond; other site
1125630006205	insertion regions; other site
1125630006206	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1125630006207	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1125630006208	substrate binding pocket [chemical binding]; other site
1125630006209	membrane-bound complex binding site; other site
1125630006210	hinge residues; other site
1125630006211	NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569
1125630006212	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
1125630006213	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
1125630006214	quinone interaction residues [chemical binding]; other site
1125630006215	active site
1125630006216	catalytic residues [active]
1125630006217	FMN binding site [chemical binding]; other site
1125630006218	substrate binding site [chemical binding]; other site
1125630006219	Protein of unknown function (DUF1379); Region: DUF1379; pfam07126
1125630006220	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
1125630006221	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
1125630006222	MOSC domain; Region: MOSC; pfam03473
1125630006223	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1125630006224	catalytic loop [active]
1125630006225	iron binding site [ion binding]; other site
1125630006226	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
1125630006227	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
1125630006228	Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170
1125630006229	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
1125630006230	putative RNA binding site [nucleotide binding]; other site
1125630006231	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1125630006232	S-adenosylmethionine binding site [chemical binding]; other site
1125630006233	ABC transporter ATPase component; Reviewed; Region: PRK11147
1125630006234	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1125630006235	ABC transporter; Region: ABC_tran_2; pfam12848
1125630006236	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1125630006237	HemX; Region: HemX; cl19375
1125630006238	paraquat-inducible membrane protein A; Provisional; Region: PRK15103
1125630006239	Paraquat-inducible protein A; Region: PqiA; pfam04403
1125630006240	Paraquat-inducible protein A; Region: PqiA; pfam04403
1125630006241	paraquat-inducible protein B; Provisional; Region: PRK10807
1125630006242	mce related protein; Region: MCE; pfam02470
1125630006243	mce related protein; Region: MCE; pfam02470
1125630006244	mce related protein; Region: MCE; pfam02470
1125630006245	Biogenesis of lysosome-related organelles complex-1 subunit 2; Region: BLOC1_2; pfam10046
1125630006246	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
1125630006247	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
1125630006248	active site 1 [active]
1125630006249	dimer interface [polypeptide binding]; other site
1125630006250	active site 2 [active]
1125630006251	Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067
1125630006252	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1125630006253	Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097
1125630006254	outer membrane protein A; Reviewed; Region: PRK10808
1125630006255	OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389
1125630006256	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1125630006257	ligand binding site [chemical binding]; other site
1125630006258	Cell division inhibitor SulA; Region: SulA; cl01880
1125630006259	TfoX N-terminal domain; Region: TfoX_N; pfam04993
1125630006260	TfoX C-terminal domain; Region: TfoX_C; pfam04994
1125630006261	TIGR01666 family membrane protein; Region: YCCS
1125630006262	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
1125630006263	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1125630006264	Domain of unknown function (DUF307); Region: DUF307; pfam03733
1125630006265	DNA helicase IV; Provisional; Region: helD; PRK11054
1125630006266	DNA helicase IV / RNA helicase N terminal; Region: Helicase_IV_N; pfam12462
1125630006267	Part of AAA domain; Region: AAA_19; pfam13245
1125630006268	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
1125630006269	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
1125630006270	active site
1125630006271	dimer interfaces [polypeptide binding]; other site
1125630006272	catalytic residues [active]
1125630006273	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
1125630006274	heat shock protein HspQ; Provisional; Region: PRK14129
1125630006275	23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128
1125630006276	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
1125630006277	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
1125630006278	putative RNA binding site [nucleotide binding]; other site
1125630006279	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1125630006280	S-adenosylmethionine binding site [chemical binding]; other site
1125630006281	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1125630006282	substrate binding site [chemical binding]; other site
1125630006283	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1125630006284	acylphosphatase; Provisional; Region: PRK14426
1125630006285	sulfur transfer protein TusE; Provisional; Region: PRK11508
1125630006286	YccA-like proteins; Region: YccA_like; cd10433
1125630006287	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1125630006288	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1125630006289	peptide binding site [polypeptide binding]; other site
1125630006290	potential frameshift: common BLAST hit: gi|288936234|ref|YP_003440293.1| diguanylate phosphodiesterase
1125630006291	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1125630006292	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1125630006293	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
1125630006294	FMN-binding pocket [chemical binding]; other site
1125630006295	flavin binding motif; other site
1125630006296	phosphate binding motif [ion binding]; other site
1125630006297	beta-alpha-beta structure motif; other site
1125630006298	NAD binding pocket [chemical binding]; other site
1125630006299	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1125630006300	catalytic loop [active]
1125630006301	iron binding site [ion binding]; other site
1125630006302	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1125630006303	tetramerization interface [polypeptide binding]; other site
1125630006304	NAD(P) binding site [chemical binding]; other site
1125630006305	catalytic residues [active]
1125630006306	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1125630006307	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
1125630006308	[2Fe-2S] cluster binding site [ion binding]; other site
1125630006309	C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886
1125630006310	putative alpha subunit interface [polypeptide binding]; other site
1125630006311	putative active site [active]
1125630006312	putative substrate binding site [chemical binding]; other site
1125630006313	Fe binding site [ion binding]; other site
1125630006314	putative transporter; Provisional; Region: PRK09950
1125630006315	potential frameshift: common BLAST hit: gi|152969571|ref|YP_001334680.1| putative tartrate dehydrogenase
1125630006316	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
1125630006317	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
1125630006318	transcriptional activator TtdR; Provisional; Region: PRK09801
1125630006319	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630006320	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
1125630006321	putative effector binding pocket; other site
1125630006322	putative dimerization interface [polypeptide binding]; other site
1125630006323	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1125630006324	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1125630006325	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
1125630006326	NAD(P) binding site [chemical binding]; other site
1125630006327	catalytic residues [active]
1125630006328	potential frameshift: common BLAST hit: gi|336249665|ref|YP_004593375.1| DNA-binding transcriptional repressor PuuR
1125630006329	Cupin domain; Region: Cupin_2; cl17218
1125630006330	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1125630006331	non-specific DNA binding site [nucleotide binding]; other site
1125630006332	salt bridge; other site
1125630006333	sequence-specific DNA binding site [nucleotide binding]; other site
1125630006334	gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366
1125630006335	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
1125630006336	catalytic triad [active]
1125630006337	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1125630006338	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1125630006339	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
1125630006340	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1125630006341	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1125630006342	classical (c) SDRs; Region: SDR_c; cd05233
1125630006343	NAD(P) binding site [chemical binding]; other site
1125630006344	active site
1125630006345	Predicted transcriptional regulators [Transcription]; Region: COG1733
1125630006346	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
1125630006347	catalytic core [active]
1125630006348	hypothetical protein; Provisional; Region: PRK10174
1125630006349	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
1125630006350	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1125630006351	EamA-like transporter family; Region: EamA; pfam00892
1125630006352	EamA-like transporter family; Region: EamA; pfam00892
1125630006353	Sulfate transporter family; Region: Sulfate_transp; cl19250
1125630006354	uracil-xanthine permease; Region: ncs2; TIGR00801
1125630006355	pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615
1125630006356	Nitroreductase-like family 5.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148
1125630006357	putative FMN binding site [chemical binding]; other site
1125630006358	potential frameshift: common BLAST hit: gi|238894074|ref|YP_002918808.1| putative hydrolase
1125630006359	pyrimidine utilization protein D; Region: RutD; TIGR03611
1125630006360	pyrimidine utilization protein D; Region: RutD; TIGR03611
1125630006361	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1125630006362	homotrimer interaction site [polypeptide binding]; other site
1125630006363	putative active site [active]
1125630006364	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1125630006365	catalytic triad [active]
1125630006366	conserved cis-peptide bond; other site
1125630006367	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
1125630006368	active site
1125630006369	dimer interface [polypeptide binding]; other site
1125630006370	non-prolyl cis peptide bond; other site
1125630006371	insertion regions; other site
1125630006372	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1125630006373	HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008
1125630006374	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1125630006375	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
1125630006376	Protein of unknown function (DUF1311); Region: DUF1311; cl01530
1125630006377	potential frameshift: common BLAST hit: gi|152969597|ref|YP_001334706.1| trifunctional transcriptional regulator/proline
1125630006378	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1125630006379	Predicted transcriptional regulator [Transcription]; Region: COG3905
1125630006380	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
1125630006381	DNA-binding domain of Proline dehydrogenase; Region: Pro_dh-DNA_bdg; pfam14850
1125630006382	Proline dehydrogenase; Region: Pro_dh; pfam01619
1125630006383	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1125630006384	NAD(P) binding site [chemical binding]; other site
1125630006385	catalytic residues [active]
1125630006386	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
1125630006387	Na binding site [ion binding]; other site
1125630006388	Protein of unknown function (DUF3574); Region: DUF3574; pfam12098
1125630006389	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1125630006390	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1125630006391	Nucleoside recognition; Region: Gate; pfam07670
1125630006392	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1125630006393	Iron permease FTR1 family; Region: FTR1; cl00475
1125630006394	inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378
1125630006395	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
1125630006396	Imelysin; Region: Peptidase_M75; pfam09375
1125630006397	Tat-translocated enzyme; Region: tat_substr_1; TIGR01412
1125630006398	potential frameshift: common BLAST hit: gi|288936184|ref|YP_003440243.1| PhoH family protein
1125630006399	PhoH-like protein; Region: PhoH; cl17668
1125630006400	PhoH-like protein; Region: PhoH; cl17668
1125630006401	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
1125630006402	catalytic residues [active]
1125630006403	hinge region; other site
1125630006404	alpha helical domain; other site
1125630006405	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
1125630006406	catalytic triad [active]
1125630006407	conserved cis-peptide bond; other site
1125630006408	Pirin-related protein [General function prediction only]; Region: COG1741
1125630006409	Pirin; Region: Pirin; pfam02678
1125630006410	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
1125630006411	LysR family transcriptional regulator; Provisional; Region: PRK14997
1125630006412	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630006413	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
1125630006414	putative effector binding pocket; other site
1125630006415	putative dimerization interface [polypeptide binding]; other site
1125630006416	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
1125630006417	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1125630006418	putative ligand binding site [chemical binding]; other site
1125630006419	NAD binding site [chemical binding]; other site
1125630006420	dimerization interface [polypeptide binding]; other site
1125630006421	catalytic site [active]
1125630006422	putative hydrolase; Validated; Region: PRK09248
1125630006423	Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437
1125630006424	active site
1125630006425	Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381
1125630006426	Protein of unknown function (DUF1097); Region: DUF1097; pfam06496
1125630006427	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
1125630006428	putative ADP-ribose binding site [chemical binding]; other site
1125630006429	putative active site [active]
1125630006430	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
1125630006431	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1125630006432	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
1125630006433	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
1125630006434	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1125630006435	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
1125630006436	Ligand binding site; other site
1125630006437	DXD motif; other site
1125630006438	lipoprotein; Provisional; Region: PRK10175
1125630006439	secY/secA suppressor protein; Provisional; Region: PRK11467
1125630006440	drug efflux system protein MdtG; Provisional; Region: PRK09874
1125630006441	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630006442	putative substrate translocation pore; other site
1125630006443	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1125630006444	putative acyl-acceptor binding pocket; other site
1125630006445	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
1125630006446	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
1125630006447	active site residue [active]
1125630006448	Protein of unknown function (DUF2770); Region: DUF2770; pfam10968
1125630006449	N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259
1125630006450	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1125630006451	biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301
1125630006452	DinI-like family; Region: DinI; cl11630
1125630006453	potential frameshift: common BLAST hit: gi|152969628|ref|YP_001334737.1| dihydroorotase
1125630006454	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1125630006455	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1125630006456	active site
1125630006457	lipoprotein; Provisional; Region: PRK10598
1125630006458	multidrug resistance protein MdtH; Provisional; Region: PRK11646
1125630006459	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630006460	putative substrate translocation pore; other site
1125630006461	ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809
1125630006462	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1125630006463	hypothetical protein; Provisional; Region: PRK11239
1125630006464	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1125630006465	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1125630006466	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
1125630006467	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
1125630006468	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1125630006469	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630006470	putative substrate translocation pore; other site
1125630006471	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630006472	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630006473	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1125630006474	putative effector binding pocket; other site
1125630006475	dimerization interface [polypeptide binding]; other site
1125630006476	Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111
1125630006477	ribonuclease E; Reviewed; Region: rne; PRK10811
1125630006478	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
1125630006479	homodimer interface [polypeptide binding]; other site
1125630006480	oligonucleotide binding site [chemical binding]; other site
1125630006481	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
1125630006482	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
1125630006483	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1125630006484	RNA binding surface [nucleotide binding]; other site
1125630006485	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1125630006486	active site
1125630006487	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1125630006488	active site
1125630006489	dimer interface [polypeptide binding]; other site
1125630006490	hypothetical protein; Provisional; Region: PRK11193
1125630006491	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
1125630006492	putative phosphate acyltransferase; Provisional; Region: PRK05331
1125630006493	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
1125630006494	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1125630006495	dimer interface [polypeptide binding]; other site
1125630006496	active site
1125630006497	CoA binding pocket [chemical binding]; other site
1125630006498	Acyl transferase domain; Region: Acyl_transf_1; cl08282
1125630006499	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1125630006500	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1125630006501	NAD(P) binding site [chemical binding]; other site
1125630006502	homotetramer interface [polypeptide binding]; other site
1125630006503	homodimer interface [polypeptide binding]; other site
1125630006504	active site
1125630006505	acyl carrier protein; Provisional; Region: acpP; PRK00982
1125630006506	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
1125630006507	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1125630006508	dimer interface [polypeptide binding]; other site
1125630006509	active site
1125630006510	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
1125630006511	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630006512	catalytic residue [active]
1125630006513	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
1125630006514	dimerization interface [polypeptide binding]; other site
1125630006515	thymidylate kinase; Validated; Region: tmk; PRK00698
1125630006516	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1125630006517	TMP-binding site; other site
1125630006518	ATP-binding site [chemical binding]; other site
1125630006519	DNA polymerase III subunit delta'; Validated; Region: PRK07993
1125630006520	DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115
1125630006521	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1125630006522	active site
1125630006523	PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089
1125630006524	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1125630006525	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1125630006526	active site turn [active]
1125630006527	phosphorylation site [posttranslational modification]
1125630006528	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
1125630006529	nucleotide binding site/active site [active]
1125630006530	HIT family signature motif; other site
1125630006531	catalytic residue [active]
1125630006532	Putative periplasmic lipoprotein; Region: DUF1425; cd09030
1125630006533	putative dimer interface [polypeptide binding]; other site
1125630006534	Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417
1125630006535	Phosphotransferase enzyme family; Region: APH; pfam01636
1125630006536	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1125630006537	active site
1125630006538	substrate binding site [chemical binding]; other site
1125630006539	ATP binding site [chemical binding]; other site
1125630006540	beta-hexosaminidase; Provisional; Region: PRK05337
1125630006541	hypothetical protein; Provisional; Region: PRK04940
1125630006542	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1125630006543	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1125630006544	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1125630006545	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1125630006546	hypothetical protein; Provisional; Region: PRK11280
1125630006547	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1125630006548	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1125630006549	N-terminal plug; other site
1125630006550	ligand-binding site [chemical binding]; other site
1125630006551	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
1125630006552	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1125630006553	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1125630006554	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1125630006555	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
1125630006556	L,D-transpeptidase; Provisional; Region: PRK10260
1125630006557	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1125630006558	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1125630006559	Domain of unknown function (DUF4330); Region: DUF4330; pfam14221
1125630006560	transcription-repair coupling factor; Provisional; Region: PRK10689
1125630006561	Bifunctional transglycosylase second domain; Region: UB2H; pfam14814
1125630006562	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
1125630006563	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1125630006564	ATP binding site [chemical binding]; other site
1125630006565	putative Mg++ binding site [ion binding]; other site
1125630006566	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1125630006567	nucleotide binding region [chemical binding]; other site
1125630006568	ATP-binding site [chemical binding]; other site
1125630006569	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
1125630006570	outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814
1125630006571	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1125630006572	FtsX-like permease family; Region: FtsX; pfam02687
1125630006573	lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629
1125630006574	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1125630006575	Walker A/P-loop; other site
1125630006576	ATP binding site [chemical binding]; other site
1125630006577	Q-loop/lid; other site
1125630006578	ABC transporter signature motif; other site
1125630006579	Walker B; other site
1125630006580	D-loop; other site
1125630006581	H-loop/switch region; other site
1125630006582	outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146
1125630006583	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1125630006584	FtsX-like permease family; Region: FtsX; pfam02687
1125630006585	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1125630006586	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1125630006587	nucleotide binding site [chemical binding]; other site
1125630006588	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
1125630006589	NAD+ binding site [chemical binding]; other site
1125630006590	substrate binding site [chemical binding]; other site
1125630006591	Zn binding site [ion binding]; other site
1125630006592	potential frameshift: common BLAST hit: gi|238894165|ref|YP_002918899.1| crotonobetaine/carnitine-CoA ligase
1125630006593	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1125630006594	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1125630006595	acyl-activating enzyme (AAE) consensus motif; other site
1125630006596	AMP binding site [chemical binding]; other site
1125630006597	active site
1125630006598	CoA binding site [chemical binding]; other site
1125630006599	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
1125630006600	NAD(P) binding site [chemical binding]; other site
1125630006601	catalytic residues [active]
1125630006602	NAD(P) binding site [chemical binding]; other site
1125630006603	catalytic residues [active]
1125630006604	spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501
1125630006605	2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate binding protein; Region: PhnS; TIGR03227
1125630006606	spermidine/putrescine ABC transporter membrane protein; Reviewed; Region: potC; PRK09500
1125630006607	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630006608	dimer interface [polypeptide binding]; other site
1125630006609	conserved gate region; other site
1125630006610	putative PBP binding loops; other site
1125630006611	ABC-ATPase subunit interface; other site
1125630006612	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1125630006613	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630006614	dimer interface [polypeptide binding]; other site
1125630006615	conserved gate region; other site
1125630006616	putative PBP binding loops; other site
1125630006617	ABC-ATPase subunit interface; other site
1125630006618	putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452
1125630006619	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
1125630006620	Walker A/P-loop; other site
1125630006621	ATP binding site [chemical binding]; other site
1125630006622	Q-loop/lid; other site
1125630006623	ABC transporter signature motif; other site
1125630006624	Walker B; other site
1125630006625	D-loop; other site
1125630006626	H-loop/switch region; other site
1125630006627	TOBE domain; Region: TOBE_2; pfam08402
1125630006628	peptidase T-like protein; Region: PepT-like; TIGR01883
1125630006629	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
1125630006630	metal binding site [ion binding]; metal-binding site
1125630006631	dimer interface [polypeptide binding]; other site
1125630006632	Uncharacterized conserved protein [Function unknown]; Region: COG2850
1125630006633	sensor protein PhoQ; Provisional; Region: PRK10815
1125630006634	PhoQ Sensor; Region: PhoQ_Sensor; pfam08918
1125630006635	HAMP domain; Region: HAMP; pfam00672
1125630006636	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
1125630006637	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1125630006638	ATP binding site [chemical binding]; other site
1125630006639	Mg2+ binding site [ion binding]; other site
1125630006640	G-X-G motif; other site
1125630006641	DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816
1125630006642	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1125630006643	active site
1125630006644	phosphorylation site [posttranslational modification]
1125630006645	intermolecular recognition site; other site
1125630006646	dimerization interface [polypeptide binding]; other site
1125630006647	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1125630006648	DNA binding site [nucleotide binding]
1125630006649	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1125630006650	Helix-turn-helix domain; Region: HTH_18; pfam12833
1125630006651	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630006652	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
1125630006653	adenylosuccinate lyase; Provisional; Region: PRK09285
1125630006654	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
1125630006655	tetramer interface [polypeptide binding]; other site
1125630006656	active site
1125630006657	putative lysogenization regulator; Reviewed; Region: PRK00218
1125630006658	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420
1125630006659	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1125630006660	Ligand Binding Site [chemical binding]; other site
1125630006661	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
1125630006662	nudix motif; other site
1125630006663	23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394
1125630006664	Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566
1125630006665	probable active site [active]
1125630006666	isocitrate dehydrogenase; Reviewed; Region: PRK07006
1125630006667	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1125630006668	dimerization interface [polypeptide binding]; other site
1125630006669	putative DNA binding site [nucleotide binding]; other site
1125630006670	putative Zn2+ binding site [ion binding]; other site
1125630006671	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1125630006672	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116
1125630006673	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
1125630006674	Protein of unknown function (DUF1272); Region: DUF1272; cl19740
1125630006675	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
1125630006676	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1125630006677	NAD binding site [chemical binding]; other site
1125630006678	catalytic Zn binding site [ion binding]; other site
1125630006679	structural Zn binding site [ion binding]; other site
1125630006680	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
1125630006681	dimerization interface [polypeptide binding]; other site
1125630006682	metal binding site [ion binding]; metal-binding site
1125630006683	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
1125630006684	dinuclear metal binding motif [ion binding]; other site
1125630006685	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
1125630006686	dimanganese center [ion binding]; other site
1125630006687	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1125630006688	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
1125630006689	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1125630006690	Helix-turn-helix domain; Region: HTH_39; pfam14090
1125630006691	EAL domain; Region: EAL; pfam00563
1125630006692	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977
1125630006693	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
1125630006694	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630006695	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
1125630006696	dimerization interface [polypeptide binding]; other site
1125630006697	substrate binding pocket [chemical binding]; other site
1125630006698	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1125630006699	dimerization interface [polypeptide binding]; other site
1125630006700	GAF domain; Region: GAF_3; pfam13492
1125630006701	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1125630006702	metal binding site [ion binding]; metal-binding site
1125630006703	active site
1125630006704	I-site; other site
1125630006705	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1125630006706	Zn2+ binding site [ion binding]; other site
1125630006707	Mg2+ binding site [ion binding]; other site
1125630006708	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1125630006709	Zn2+ binding site [ion binding]; other site
1125630006710	Mg2+ binding site [ion binding]; other site
1125630006711	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
1125630006712	active site
1125630006713	homotetramer interface [polypeptide binding]; other site
1125630006714	homodimer interface [polypeptide binding]; other site
1125630006715	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1125630006716	putative acyl-acceptor binding pocket; other site
1125630006717	leucine export protein LeuE; Provisional; Region: PRK10958
1125630006718	Protein of unknown function (DUF2534); Region: DUF2534; pfam10749
1125630006719	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1125630006720	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1125630006721	metal binding site [ion binding]; metal-binding site
1125630006722	active site
1125630006723	I-site; other site
1125630006724	Domain of unknown function (DUF333); Region: DUF333; pfam03891
1125630006725	Protein of unknown function, DUF488; Region: DUF488; cl01246
1125630006726	Uncharacterized conserved protein [Function unknown]; Region: COG1683
1125630006727	hypothetical protein; Validated; Region: PRK06186
1125630006728	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1125630006729	conserved cys residue [active]
1125630006730	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
1125630006731	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630006732	putative substrate translocation pore; other site
1125630006733	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1125630006734	Predicted membrane protein [Function unknown]; Region: COG2707
1125630006735	YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function.  The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336
1125630006736	putative deacylase active site [active]
1125630006737	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1125630006738	DinI-like family; Region: DinI; cl11630
1125630006739	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1125630006740	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1125630006741	putative active site [active]
1125630006742	putative NTP binding site [chemical binding]; other site
1125630006743	putative nucleic acid binding site [nucleotide binding]; other site
1125630006744	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
1125630006745	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1125630006746	Catalytic site [active]
1125630006747	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
1125630006748	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
1125630006749	active site
1125630006750	DNA binding site [nucleotide binding]
1125630006751	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
1125630006752	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630006753	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630006754	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
1125630006755	putative effector binding pocket; other site
1125630006756	putative dimerization interface [polypeptide binding]; other site
1125630006757	short chain dehydrogenase; Provisional; Region: PRK06500
1125630006758	classical (c) SDRs; Region: SDR_c; cd05233
1125630006759	NAD(P) binding site [chemical binding]; other site
1125630006760	active site
1125630006761	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1125630006762	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630006763	putative substrate translocation pore; other site
1125630006764	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630006765	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630006766	LysR substrate binding domain; Region: LysR_substrate; pfam03466
1125630006767	dimerization interface [polypeptide binding]; other site
1125630006768	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1125630006769	catalytic residues [active]
1125630006770	dimer interface [polypeptide binding]; other site
1125630006771	Uncharacterized conserved protein [Function unknown]; Region: COG2718
1125630006772	PrkA family serine protein kinase; Provisional; Region: PRK15455
1125630006773	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1125630006774	Walker A motif; other site
1125630006775	ATP binding site [chemical binding]; other site
1125630006776	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
1125630006777	Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713
1125630006778	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1125630006779	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
1125630006780	active site
1125630006781	catalytic tetrad [active]
1125630006782	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
1125630006783	active site
1125630006784	phosphate binding residues; other site
1125630006785	catalytic residues [active]
1125630006786	glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425
1125630006787	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1125630006788	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1125630006789	methionine sulfoxide reductase B; Provisional; Region: PRK00222
1125630006790	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139
1125630006791	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1125630006792	active site
1125630006793	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
1125630006794	Glyco_18 domain; Region: Glyco_18; smart00636
1125630006795	active site
1125630006796	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1125630006797	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1125630006798	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1125630006799	NAD(P) binding site [chemical binding]; other site
1125630006800	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630006801	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1125630006802	putative substrate translocation pore; other site
1125630006803	Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285
1125630006804	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1125630006805	inhibitor binding site; inhibition site
1125630006806	catalytic Zn binding site [ion binding]; other site
1125630006807	structural Zn binding site [ion binding]; other site
1125630006808	NADP binding site [chemical binding]; other site
1125630006809	tetramer interface [polypeptide binding]; other site
1125630006810	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1125630006811	intersubunit interface [polypeptide binding]; other site
1125630006812	active site
1125630006813	zinc binding site [ion binding]; other site
1125630006814	Na+ binding site [ion binding]; other site
1125630006815	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1125630006816	substrate binding site [chemical binding]; other site
1125630006817	ATP binding site [chemical binding]; other site
1125630006818	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1125630006819	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
1125630006820	active site
1125630006821	catalytic tetrad [active]
1125630006822	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1125630006823	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1125630006824	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1125630006825	benzoate transport; Region: 2A0115; TIGR00895
1125630006826	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630006827	putative substrate translocation pore; other site
1125630006828	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
1125630006829	catalytic triad [active]
1125630006830	metal binding site [ion binding]; metal-binding site
1125630006831	conserved cis-peptide bond; other site
1125630006832	cytoplasmic asparaginase I; Provisional; Region: ansA; PRK09461
1125630006833	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
1125630006834	active site
1125630006835	homodimer interface [polypeptide binding]; other site
1125630006836	protease 4; Provisional; Region: PRK10949
1125630006837	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
1125630006838	tandem repeat interface [polypeptide binding]; other site
1125630006839	oligomer interface [polypeptide binding]; other site
1125630006840	active site residues [active]
1125630006841	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019
1125630006842	tandem repeat interface [polypeptide binding]; other site
1125630006843	oligomer interface [polypeptide binding]; other site
1125630006844	active site residues [active]
1125630006845	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
1125630006846	putative FMN binding site [chemical binding]; other site
1125630006847	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1125630006848	Helix-turn-helix domain; Region: HTH_28; pfam13518
1125630006849	Helix-turn-helix domain; Region: HTH_28; pfam13518
1125630006850	putative transposase OrfB; Reviewed; Region: PHA02517
1125630006851	HTH-like domain; Region: HTH_21; pfam13276
1125630006852	Integrase core domain; Region: rve; pfam00665
1125630006853	Integrase core domain; Region: rve_2; pfam13333
1125630006854	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
1125630006855	active site
1125630006856	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1125630006857	selenophosphate synthetase; Provisional; Region: PRK00943
1125630006858	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
1125630006859	dimerization interface [polypeptide binding]; other site
1125630006860	putative ATP binding site [chemical binding]; other site
1125630006861	potential frameshift: common BLAST hit: gi|238894263|ref|YP_002918997.1| DNA topoisomerase III
1125630006862	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
1125630006863	active site
1125630006864	putative interdomain interaction site [polypeptide binding]; other site
1125630006865	putative metal-binding site [ion binding]; other site
1125630006866	putative nucleotide binding site [chemical binding]; other site
1125630006867	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1125630006868	domain I; other site
1125630006869	phosphate binding site [ion binding]; other site
1125630006870	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1125630006871	nucleotide binding site [chemical binding]; other site
1125630006872	domain II; other site
1125630006873	domain IV; other site
1125630006874	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
1125630006875	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
1125630006876	NAD(P) binding site [chemical binding]; other site
1125630006877	glutamate dehydrogenase; Provisional; Region: PRK09414
1125630006878	Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812
1125630006879	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
1125630006880	NAD(P) binding site [chemical binding]; other site
1125630006881	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
1125630006882	active site
1125630006883	8-oxo-dGMP binding site [chemical binding]; other site
1125630006884	nudix motif; other site
1125630006885	metal binding site [ion binding]; metal-binding site
1125630006886	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
1125630006887	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
1125630006888	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
1125630006889	active site residue [active]
1125630006890	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1125630006891	active site residue [active]
1125630006892	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136
1125630006893	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1125630006894	Walker A/P-loop; other site
1125630006895	ATP binding site [chemical binding]; other site
1125630006896	Q-loop/lid; other site
1125630006897	ABC transporter signature motif; other site
1125630006898	Walker B; other site
1125630006899	D-loop; other site
1125630006900	H-loop/switch region; other site
1125630006901	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135
1125630006902	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630006903	putative PBP binding loops; other site
1125630006904	dimer interface [polypeptide binding]; other site
1125630006905	ABC-ATPase subunit interface; other site
1125630006906	hypothetical protein; Provisional; Region: PRK11622
1125630006907	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1125630006908	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1125630006909	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1125630006910	potential frameshift: common BLAST hit: gi|238900964|ref|YP_002926760.1| putative inner membrane protein
1125630006911	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1125630006912	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1125630006913	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
1125630006914	putative catalytic site [active]
1125630006915	putative phosphate binding site [ion binding]; other site
1125630006916	active site
1125630006917	metal binding site A [ion binding]; metal-binding site
1125630006918	DNA binding site [nucleotide binding]
1125630006919	putative AP binding site [nucleotide binding]; other site
1125630006920	putative metal binding site B [ion binding]; other site
1125630006921	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
1125630006922	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1125630006923	inhibitor-cofactor binding pocket; inhibition site
1125630006924	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630006925	catalytic residue [active]
1125630006926	arginine succinyltransferase; Provisional; Region: PRK10456
1125630006927	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
1125630006928	NAD(P) binding site [chemical binding]; other site
1125630006929	catalytic residues [active]
1125630006930	succinylarginine dihydrolase; Provisional; Region: PRK13281
1125630006931	Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855
1125630006932	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
1125630006933	putative active site [active]
1125630006934	Zn binding site [ion binding]; other site
1125630006935	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
1125630006936	dimer interface [polypeptide binding]; other site
1125630006937	nucleotide excision repair endonuclease; Provisional; Region: PRK10545
1125630006938	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1125630006939	GIY-YIG motif/motif A; other site
1125630006940	active site
1125630006941	catalytic site [active]
1125630006942	putative DNA binding site [nucleotide binding]; other site
1125630006943	metal binding site [ion binding]; metal-binding site
1125630006944	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1125630006945	homodimer interface [polypeptide binding]; other site
1125630006946	NAD binding pocket [chemical binding]; other site
1125630006947	ATP binding pocket [chemical binding]; other site
1125630006948	Mg binding site [ion binding]; other site
1125630006949	active-site loop [active]
1125630006950	DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251
1125630006951	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
1125630006952	active site
1125630006953	P-loop; other site
1125630006954	phosphorylation site [posttranslational modification]
1125630006955	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295
1125630006956	PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297
1125630006957	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
1125630006958	methionine cluster; other site
1125630006959	active site
1125630006960	phosphorylation site [posttranslational modification]
1125630006961	metal binding site [ion binding]; metal-binding site
1125630006962	DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296
1125630006963	Cupin domain; Region: Cupin_2; cl17218
1125630006964	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630006965	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
1125630006966	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
1125630006967	NAD binding site [chemical binding]; other site
1125630006968	sugar binding site [chemical binding]; other site
1125630006969	divalent metal binding site [ion binding]; other site
1125630006970	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1125630006971	dimer interface [polypeptide binding]; other site
1125630006972	Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803
1125630006973	putative active site [active]
1125630006974	YdjC motif; other site
1125630006975	Mg binding site [ion binding]; other site
1125630006976	putative homodimer interface [polypeptide binding]; other site
1125630006977	hydroperoxidase II; Provisional; Region: katE; PRK11249
1125630006978	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
1125630006979	tetramer interface [polypeptide binding]; other site
1125630006980	heme binding pocket [chemical binding]; other site
1125630006981	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
1125630006982	domain interactions; other site
1125630006983	Cell division activator CedA; Region: CedA; cl11674
1125630006984	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
1125630006985	inner membrane protein; Provisional; Region: PRK11648
1125630006986	2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993
1125630006987	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
1125630006988	NADP binding site [chemical binding]; other site
1125630006989	homodimer interface [polypeptide binding]; other site
1125630006990	active site
1125630006991	2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826
1125630006992	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
1125630006993	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1125630006994	motif II; other site
1125630006995	YniB-like protein; Region: YniB; pfam14002
1125630006996	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1125630006997	outer membrane receptor FepA; Provisional; Region: PRK13528
1125630006998	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1125630006999	N-terminal plug; other site
1125630007000	ligand-binding site [chemical binding]; other site
1125630007001	intracellular septation protein A; Reviewed; Region: PRK00259
1125630007002	hypothetical protein; Provisional; Region: PRK02868
1125630007003	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
1125630007004	outer membrane protein W; Provisional; Region: PRK10959
1125630007005	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
1125630007006	catecholate siderophore receptor Fiu; Provisional; Region: PRK09840
1125630007007	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1125630007008	N-terminal plug; other site
1125630007009	ligand-binding site [chemical binding]; other site
1125630007010	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1125630007011	short chain dehydrogenase; Region: adh_short; pfam00106
1125630007012	NAD(P) binding site [chemical binding]; other site
1125630007013	active site
1125630007014	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1125630007015	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1125630007016	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1125630007017	NAD(P) binding site [chemical binding]; other site
1125630007018	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1125630007019	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1125630007020	putative DNA binding site [nucleotide binding]; other site
1125630007021	putative Zn2+ binding site [ion binding]; other site
1125630007022	MarR family; Region: MarR_2; cl17246
1125630007023	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630007024	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630007025	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
1125630007026	dimerization interface [polypeptide binding]; other site
1125630007027	substrate binding pocket [chemical binding]; other site
1125630007028	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
1125630007029	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630007030	putative substrate translocation pore; other site
1125630007031	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
1125630007032	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
1125630007033	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
1125630007034	MOFRL family; Region: MOFRL; pfam05161
1125630007035	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
1125630007036	substrate binding site [chemical binding]; other site
1125630007037	active site
1125630007038	catalytic residues [active]
1125630007039	heterodimer interface [polypeptide binding]; other site
1125630007040	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1125630007041	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630007042	catalytic residue [active]
1125630007043	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
1125630007044	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1125630007045	active site
1125630007046	ribulose/triose binding site [chemical binding]; other site
1125630007047	phosphate binding site [ion binding]; other site
1125630007048	substrate (anthranilate) binding pocket [chemical binding]; other site
1125630007049	product (indole) binding pocket [chemical binding]; other site
1125630007050	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
1125630007051	active site
1125630007052	bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522
1125630007053	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1125630007054	glutamine binding [chemical binding]; other site
1125630007055	catalytic triad [active]
1125630007056	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1125630007057	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1125630007058	anthranilate synthase component I; Provisional; Region: PRK13564
1125630007059	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1125630007060	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1125630007061	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
1125630007062	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
1125630007063	active site
1125630007064	hypothetical protein; Provisional; Region: PRK11630
1125630007065	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1125630007066	EamA-like transporter family; Region: EamA; pfam00892
1125630007067	EamA-like transporter family; Region: EamA; pfam00892
1125630007068	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1125630007069	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630007070	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1125630007071	dimerization interface [polypeptide binding]; other site
1125630007072	substrate binding pocket [chemical binding]; other site
1125630007073	23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700
1125630007074	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1125630007075	RNA binding surface [nucleotide binding]; other site
1125630007076	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
1125630007077	probable active site [active]
1125630007078	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
1125630007079	cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986
1125630007080	Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340
1125630007081	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1125630007082	NADP binding site [chemical binding]; other site
1125630007083	homodimer interface [polypeptide binding]; other site
1125630007084	active site
1125630007085	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
1125630007086	putative inner membrane peptidase; Provisional; Region: PRK11778
1125630007087	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
1125630007088	tandem repeat interface [polypeptide binding]; other site
1125630007089	oligomer interface [polypeptide binding]; other site
1125630007090	active site residues [active]
1125630007091	hypothetical protein; Provisional; Region: PRK11037
1125630007092	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
1125630007093	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1125630007094	active site
1125630007095	interdomain interaction site; other site
1125630007096	putative metal-binding site [ion binding]; other site
1125630007097	nucleotide binding site [chemical binding]; other site
1125630007098	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1125630007099	domain I; other site
1125630007100	DNA binding groove [nucleotide binding]
1125630007101	phosphate binding site [ion binding]; other site
1125630007102	domain II; other site
1125630007103	domain III; other site
1125630007104	nucleotide binding site [chemical binding]; other site
1125630007105	catalytic site [active]
1125630007106	domain IV; other site
1125630007107	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1125630007108	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1125630007109	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
1125630007110	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
1125630007111	transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681
1125630007112	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630007113	The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443
1125630007114	substrate binding site [chemical binding]; other site
1125630007115	putative dimerization interface [polypeptide binding]; other site
1125630007116	aconitate hydratase; Validated; Region: PRK09277
1125630007117	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
1125630007118	substrate binding site [chemical binding]; other site
1125630007119	ligand binding site [chemical binding]; other site
1125630007120	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
1125630007121	substrate binding site [chemical binding]; other site
1125630007122	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
1125630007123	dimerization interface [polypeptide binding]; other site
1125630007124	active site
1125630007125	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1125630007126	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
1125630007127	active site
1125630007128	Predicted membrane protein [Function unknown]; Region: COG3771
1125630007129	potential frameshift: common BLAST hit: gi|152969830|ref|YP_001334939.1| tetratricopeptide repeat protein
1125630007130	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1125630007131	TPR motif; other site
1125630007132	binding surface
1125630007133	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1125630007134	binding surface
1125630007135	TPR motif; other site
1125630007136	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1125630007137	Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956
1125630007138	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1125630007139	active site
1125630007140	dimer interface [polypeptide binding]; other site
1125630007141	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
1125630007142	putative rRNA binding site [nucleotide binding]; other site
1125630007143	lipoprotein; Provisional; Region: PRK10540
1125630007144	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1125630007145	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1125630007146	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1125630007147	hypothetical protein; Provisional; Region: PRK13658
1125630007148	exoribonuclease II; Provisional; Region: PRK05054
1125630007149	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
1125630007150	RNB domain; Region: RNB; pfam00773
1125630007151	S1 RNA binding domain; Region: S1; pfam00575
1125630007152	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731
1125630007153	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1125630007154	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
1125630007155	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
1125630007156	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
1125630007157	NAD binding site [chemical binding]; other site
1125630007158	homotetramer interface [polypeptide binding]; other site
1125630007159	homodimer interface [polypeptide binding]; other site
1125630007160	substrate binding site [chemical binding]; other site
1125630007161	active site
1125630007162	HutD; Region: HutD; pfam05962
1125630007163	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1125630007164	Na binding site [ion binding]; other site
1125630007165	antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112
1125630007166	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1125630007167	Walker A/P-loop; other site
1125630007168	ATP binding site [chemical binding]; other site
1125630007169	Q-loop/lid; other site
1125630007170	ABC transporter signature motif; other site
1125630007171	Walker B; other site
1125630007172	D-loop; other site
1125630007173	H-loop/switch region; other site
1125630007174	antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093
1125630007175	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1125630007176	Walker A/P-loop; other site
1125630007177	ATP binding site [chemical binding]; other site
1125630007178	Q-loop/lid; other site
1125630007179	ABC transporter signature motif; other site
1125630007180	Walker B; other site
1125630007181	D-loop; other site
1125630007182	H-loop/switch region; other site
1125630007183	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1125630007184	antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111
1125630007185	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1125630007186	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630007187	dimer interface [polypeptide binding]; other site
1125630007188	conserved gate region; other site
1125630007189	putative PBP binding loops; other site
1125630007190	ABC-ATPase subunit interface; other site
1125630007191	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630007192	dimer interface [polypeptide binding]; other site
1125630007193	conserved gate region; other site
1125630007194	putative PBP binding loops; other site
1125630007195	ABC-ATPase subunit interface; other site
1125630007196	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
1125630007197	peptide binding site [polypeptide binding]; other site
1125630007198	atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262
1125630007199	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1125630007200	putative NAD(P) binding site [chemical binding]; other site
1125630007201	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1125630007202	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1125630007203	salt bridge; other site
1125630007204	non-specific DNA binding site [nucleotide binding]; other site
1125630007205	sequence-specific DNA binding site [nucleotide binding]; other site
1125630007206	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630007207	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1125630007208	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630007209	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664
1125630007210	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1125630007211	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
1125630007212	metal binding site [ion binding]; metal-binding site
1125630007213	putative dimer interface [polypeptide binding]; other site
1125630007214	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1125630007215	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630007216	putative substrate translocation pore; other site
1125630007217	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630007218	putative substrate translocation pore; other site
1125630007219	phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608
1125630007220	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1125630007221	Walker A motif; other site
1125630007222	ATP binding site [chemical binding]; other site
1125630007223	Walker B motif; other site
1125630007224	arginine finger; other site
1125630007225	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1125630007226	phage shock protein PspA; Provisional; Region: PRK10698
1125630007227	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
1125630007228	phage shock protein B; Provisional; Region: pspB; PRK09458
1125630007229	DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697
1125630007230	phage shock protein C; Region: phageshock_pspC; TIGR02978
1125630007231	peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497
1125630007232	Predicted ATPase [General function prediction only]; Region: COG3106
1125630007233	hypothetical protein; Provisional; Region: PRK05415
1125630007234	Predicted membrane protein [Function unknown]; Region: COG3768
1125630007235	DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086
1125630007236	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630007237	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1125630007238	dimerization interface [polypeptide binding]; other site
1125630007239	substrate binding pocket [chemical binding]; other site
1125630007240	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
1125630007241	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
1125630007242	NAD binding site [chemical binding]; other site
1125630007243	sugar binding site [chemical binding]; other site
1125630007244	divalent metal binding site [ion binding]; other site
1125630007245	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1125630007246	dimer interface [polypeptide binding]; other site
1125630007247	DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820
1125630007248	N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877
1125630007249	putative aromatic amino acid binding site; other site
1125630007250	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1125630007251	putative active site [active]
1125630007252	heme pocket [chemical binding]; other site
1125630007253	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1125630007254	Walker A motif; other site
1125630007255	ATP binding site [chemical binding]; other site
1125630007256	Walker B motif; other site
1125630007257	arginine finger; other site
1125630007258	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
1125630007259	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
1125630007260	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
1125630007261	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
1125630007262	dimer interface [polypeptide binding]; other site
1125630007263	catalytic triad [active]
1125630007264	peroxidatic and resolving cysteines [active]
1125630007265	L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129
1125630007266	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
1125630007267	active site
1125630007268	Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904
1125630007269	putative active site [active]
1125630007270	Zn binding site [ion binding]; other site
1125630007271	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1125630007272	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1125630007273	peptide binding site [polypeptide binding]; other site
1125630007274	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1125630007275	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630007276	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630007277	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
1125630007278	putative effector binding pocket; other site
1125630007279	putative dimerization interface [polypeptide binding]; other site
1125630007280	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
1125630007281	Putative lysophospholipase; Region: Hydrolase_4; cl19140
1125630007282	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1125630007283	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630007284	putative substrate translocation pore; other site
1125630007285	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1125630007286	active site
1125630007287	catalytic tetrad [active]
1125630007288	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
1125630007289	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630007290	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630007291	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
1125630007292	putative effector binding pocket; other site
1125630007293	putative dimerization interface [polypeptide binding]; other site
1125630007294	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1125630007295	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1125630007296	NAD(P) binding site [chemical binding]; other site
1125630007297	active site
1125630007298	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
1125630007299	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1125630007300	Zn2+ binding site [ion binding]; other site
1125630007301	Mg2+ binding site [ion binding]; other site
1125630007302	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
1125630007303	conserved cys residue [active]
1125630007304	integrase; Provisional; Region: PRK09692
1125630007305	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
1125630007306	active site
1125630007307	Int/Topo IB signature motif; other site
1125630007308	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
1125630007309	core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107
1125630007310	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1125630007311	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1125630007312	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1125630007313	ATP binding site [chemical binding]; other site
1125630007314	putative Mg++ binding site [ion binding]; other site
1125630007315	helicase superfamily c-terminal domain; Region: HELICc; smart00490
1125630007316	Ribosomal L37ae protein family; Region: Ribosomal_L37ae; cl19284
1125630007317	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643
1125630007318	Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778
1125630007319	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
1125630007320	active site
1125630007321	metal binding site [ion binding]; metal-binding site
1125630007322	interdomain interaction site; other site
1125630007323	Antitermination protein; Region: Antiterm; pfam03589
1125630007324	Antitermination protein; Region: Antiterm; pfam03589
1125630007325	Lysis protein S; Region: Lysis_S; pfam04971
1125630007326	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
1125630007327	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1125630007328	zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005
1125630007329	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1125630007330	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
1125630007331	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1125630007332	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
1125630007333	Transposase; Region: HTH_Tnp_1; pfam01527
1125630007334	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1125630007335	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
1125630007336	catalytic residues [active]
1125630007337	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cl10030
1125630007338	Phage terminase large subunit; Region: Terminase_3; cl12054
1125630007339	Protein of unknown function (DUF1073); Region: DUF1073; pfam06381
1125630007340	Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; cl19842
1125630007341	Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950
1125630007342	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
1125630007343	Protein of unknown function (DUF4054); Region: DUF4054; pfam13262
1125630007344	Predicted amidohydrolase [General function prediction only]; Region: COG3964
1125630007345	Protein of unknown function (DUF3383); Region: DUF3383; pfam11863
1125630007346	Protein of unknown function (DUF3277); Region: DUF3277; pfam11681
1125630007347	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1125630007348	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1125630007349	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1125630007350	catalytic residue [active]
1125630007351	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1125630007352	Baseplate J-like protein; Region: Baseplate_J; cl01294
1125630007353	Protein of unknown function (DUF2612); Region: DUF2612; pfam11041
1125630007354	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1125630007355	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1125630007356	putative active site [active]
1125630007357	putative NTP binding site [chemical binding]; other site
1125630007358	putative nucleic acid binding site [nucleotide binding]; other site
1125630007359	DinI-like family; Region: DinI; pfam06183
1125630007360	Protein of unknown function (DUF770); Region: DUF770; pfam05591
1125630007361	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517
1125630007362	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
1125630007363	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850
1125630007364	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1125630007365	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1125630007366	ligand binding site [chemical binding]; other site
1125630007367	type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344
1125630007368	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
1125630007369	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1125630007370	Walker A motif; other site
1125630007371	ATP binding site [chemical binding]; other site
1125630007372	Walker B motif; other site
1125630007373	arginine finger; other site
1125630007374	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1125630007375	Walker A motif; other site
1125630007376	ATP binding site [chemical binding]; other site
1125630007377	Walker B motif; other site
1125630007378	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1125630007379	Rhs element Vgr protein; Region: vgr_GE; TIGR01646
1125630007380	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
1125630007381	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
1125630007382	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
1125630007383	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
1125630007384	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
1125630007385	Protein of unknown function (DUF3304); Region: DUF3304; pfam11745
1125630007386	Protein of unknown function (DUF3304); Region: DUF3304; pfam11745
1125630007387	Protein of unknown function (DUF3304); Region: DUF3304; pfam11745
1125630007388	Protein of unknown function (DUF3304); Region: DUF3304; pfam11745
1125630007389	potential frameshift: common BLAST hit: gi|206580265|ref|YP_002238883.1| lipoprotein
1125630007390	Uncharacterized alpha/beta hydrolase domain (DUF2235); Region: DUF2235; cl01480
1125630007391	Uncharacterized alpha/beta hydrolase domain (DUF2235); Region: DUF2235; cl01480
1125630007392	PAAR motif; Region: PAAR_motif; pfam05488
1125630007393	Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and    vesicular transport]; Region: IcmF; COG3523
1125630007394	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
1125630007395	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
1125630007396	potential frameshift: common BLAST hit: gi|288935816|ref|YP_003439875.1| type VI secretion-associated protein
1125630007397	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
1125630007398	type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362
1125630007399	Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947
1125630007400	Protein of unknown function (DUF1305); Region: DUF1305; pfam06996
1125630007401	Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790
1125630007402	oxidoreductase; Provisional; Region: PRK12742
1125630007403	classical (c) SDRs; Region: SDR_c; cd05233
1125630007404	NAD(P) binding site [chemical binding]; other site
1125630007405	active site
1125630007406	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1125630007407	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1125630007408	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1125630007409	short chain dehydrogenase; Provisional; Region: PRK12939
1125630007410	NAD(P) binding site [chemical binding]; other site
1125630007411	active site
1125630007412	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
1125630007413	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630007414	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1125630007415	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
1125630007416	phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259
1125630007417	NAD(P) binding site [chemical binding]; other site
1125630007418	active site lysine
1125630007419	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630007420	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630007421	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
1125630007422	putative effector binding pocket; other site
1125630007423	putative dimerization interface [polypeptide binding]; other site
1125630007424	potential frameshift: common BLAST hit: gi|152969909|ref|YP_001335018.1| transcriptional regulator LysR
1125630007425	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1125630007426	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630007427	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630007428	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630007429	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1125630007430	dimerization interface [polypeptide binding]; other site
1125630007431	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1125630007432	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1125630007433	NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251
1125630007434	NADP binding site [chemical binding]; other site
1125630007435	active site
1125630007436	regulatory binding site [polypeptide binding]; other site
1125630007437	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1125630007438	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1125630007439	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
1125630007440	putative NAD(P) binding site [chemical binding]; other site
1125630007441	LL-diaminopimelate aminotransferase; Region: DapC_direct; TIGR03540
1125630007442	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1125630007443	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630007444	homodimer interface [polypeptide binding]; other site
1125630007445	catalytic residue [active]
1125630007446	NLPA lipoprotein; Region: Lipoprotein_9; cl19159
1125630007447	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
1125630007448	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1125630007449	Walker A/P-loop; other site
1125630007450	ATP binding site [chemical binding]; other site
1125630007451	Q-loop/lid; other site
1125630007452	ABC transporter signature motif; other site
1125630007453	Walker B; other site
1125630007454	D-loop; other site
1125630007455	H-loop/switch region; other site
1125630007456	NIL domain; Region: NIL; pfam09383
1125630007457	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
1125630007458	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630007459	dimer interface [polypeptide binding]; other site
1125630007460	conserved gate region; other site
1125630007461	putative PBP binding loops; other site
1125630007462	ABC-ATPase subunit interface; other site
1125630007463	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
1125630007464	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1125630007465	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630007466	homodimer interface [polypeptide binding]; other site
1125630007467	catalytic residue [active]
1125630007468	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1125630007469	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1125630007470	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1125630007471	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1125630007472	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
1125630007473	putative DNA binding site [nucleotide binding]; other site
1125630007474	putative Zn2+ binding site [ion binding]; other site
1125630007475	aromatic amino acid transporter; Provisional; Region: PRK10238
1125630007476	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
1125630007477	putative oxidoreductase; Provisional; Region: PRK11579
1125630007478	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1125630007479	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1125630007480	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1125630007481	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1125630007482	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1125630007483	Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833
1125630007484	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
1125630007485	Cl binding site [ion binding]; other site
1125630007486	oligomer interface [polypeptide binding]; other site
1125630007487	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
1125630007488	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1125630007489	ATP binding site [chemical binding]; other site
1125630007490	Mg++ binding site [ion binding]; other site
1125630007491	motif III; other site
1125630007492	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1125630007493	nucleotide binding region [chemical binding]; other site
1125630007494	ATP-binding site [chemical binding]; other site
1125630007495	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
1125630007496	putative RNA binding site [nucleotide binding]; other site
1125630007497	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
1125630007498	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
1125630007499	Ligand Binding Site [chemical binding]; other site
1125630007500	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1125630007501	Ligand Binding Site [chemical binding]; other site
1125630007502	KTSC domain; Region: KTSC; pfam13619
1125630007503	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1125630007504	trimer interface [polypeptide binding]; other site
1125630007505	eyelet of channel; other site
1125630007506	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
1125630007507	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1125630007508	dimer interface [polypeptide binding]; other site
1125630007509	PYR/PP interface [polypeptide binding]; other site
1125630007510	TPP binding site [chemical binding]; other site
1125630007511	substrate binding site [chemical binding]; other site
1125630007512	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
1125630007513	Domain of unknown function; Region: EKR; pfam10371
1125630007514	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
1125630007515	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
1125630007516	TPP-binding site [chemical binding]; other site
1125630007517	dimer interface [polypeptide binding]; other site
1125630007518	Domain of unknown function (DUF333); Region: DUF333; cl19829
1125630007519	META domain; Region: META; cl01245
1125630007520	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
1125630007521	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1125630007522	putative ligand binding site [chemical binding]; other site
1125630007523	putative NAD binding site [chemical binding]; other site
1125630007524	catalytic site [active]
1125630007525	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1125630007526	Dicarboxylate transport; Region: DctA-YdbH; cl14674
1125630007527	Dicarboxylate transport; Region: DctA-YdbH; cl14674
1125630007528	Dicarboxylate transport; Region: DctA-YdbH; cl14674
1125630007529	YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617
1125630007530	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784
1125630007531	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
1125630007532	AraC-binding-like domain; Region: AraC_binding_2; pfam14525
1125630007533	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630007534	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1125630007535	NAD(P) binding site [chemical binding]; other site
1125630007536	catalytic residues [active]
1125630007537	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
1125630007538	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1125630007539	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1125630007540	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1125630007541	2-enoyl thioester reductase-like; Region: ETR_like; cd05282
1125630007542	NADP binding site [chemical binding]; other site
1125630007543	dimer interface [polypeptide binding]; other site
1125630007544	tyramine oxidase; Provisional; Region: tynA; PRK14696
1125630007545	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1125630007546	Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727
1125630007547	Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728
1125630007548	Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179
1125630007549	bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563
1125630007550	N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128
1125630007551	substrate binding site [chemical binding]; other site
1125630007552	dimer interface [polypeptide binding]; other site
1125630007553	NADP binding site [chemical binding]; other site
1125630007554	catalytic residues [active]
1125630007555	MaoC_C  The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452
1125630007556	substrate binding site [chemical binding]; other site
1125630007557	phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778
1125630007558	phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781
1125630007559	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138
1125630007560	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
1125630007561	phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159
1125630007562	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
1125630007563	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
1125630007564	FAD binding pocket [chemical binding]; other site
1125630007565	FAD binding motif [chemical binding]; other site
1125630007566	phosphate binding motif [ion binding]; other site
1125630007567	beta-alpha-beta structure motif; other site
1125630007568	NAD(p) ribose binding residues [chemical binding]; other site
1125630007569	NAD binding pocket [chemical binding]; other site
1125630007570	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
1125630007571	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1125630007572	catalytic loop [active]
1125630007573	iron binding site [ion binding]; other site
1125630007574	enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674
1125630007575	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1125630007576	substrate binding site [chemical binding]; other site
1125630007577	oxyanion hole (OAH) forming residues; other site
1125630007578	trimer interface [polypeptide binding]; other site
1125630007579	enoyl-CoA hydratase; Provisional; Region: PRK08140
1125630007580	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1125630007581	substrate binding site [chemical binding]; other site
1125630007582	oxyanion hole (OAH) forming residues; other site
1125630007583	trimer interface [polypeptide binding]; other site
1125630007584	3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268
1125630007585	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1125630007586	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1125630007587	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1125630007588	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1125630007589	CoenzymeA binding site [chemical binding]; other site
1125630007590	subunit interaction site [polypeptide binding]; other site
1125630007591	PHB binding site; other site
1125630007592	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
1125630007593	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1125630007594	dimer interface [polypeptide binding]; other site
1125630007595	active site
1125630007596	Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913
1125630007597	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
1125630007598	active site
1125630007599	AMP binding site [chemical binding]; other site
1125630007600	homodimer interface [polypeptide binding]; other site
1125630007601	acyl-activating enzyme (AAE) consensus motif; other site
1125630007602	CoA binding site [chemical binding]; other site
1125630007603	PaaX-like protein; Region: PaaX; pfam07848
1125630007604	phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277
1125630007605	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
1125630007606	phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287
1125630007607	paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745
1125630007608	putative trimer interface [polypeptide binding]; other site
1125630007609	putative metal binding site [ion binding]; other site
1125630007610	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
1125630007611	azoreductase; Reviewed; Region: PRK00170
1125630007612	ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
1125630007613	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1125630007614	ATP binding site [chemical binding]; other site
1125630007615	putative Mg++ binding site [ion binding]; other site
1125630007616	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1125630007617	nucleotide binding region [chemical binding]; other site
1125630007618	ATP-binding site [chemical binding]; other site
1125630007619	Helicase associated domain (HA2); Region: HA2; pfam04408
1125630007620	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
1125630007621	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
1125630007622	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1125630007623	S-adenosylmethionine binding site [chemical binding]; other site
1125630007624	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
1125630007625	Outer membrane efflux protein; Region: OEP; pfam02321
1125630007626	Outer membrane efflux protein; Region: OEP; pfam02321
1125630007627	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
1125630007628	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1125630007629	HlyD family secretion protein; Region: HlyD_3; pfam13437
1125630007630	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630007631	putative substrate translocation pore; other site
1125630007632	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1125630007633	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1125630007634	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1125630007635	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630007636	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630007637	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1125630007638	dimerization interface [polypeptide binding]; other site
1125630007639	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1125630007640	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
1125630007641	active site
1125630007642	catalytic tetrad [active]
1125630007643	potential frameshift: common BLAST hit: gi|238894504|ref|YP_002919238.1| putative glutamic dehyrogenase-like protein
1125630007644	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
1125630007645	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
1125630007646	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
1125630007647	Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812
1125630007648	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
1125630007649	NAD(P) binding pocket [chemical binding]; other site
1125630007650	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
1125630007651	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1125630007652	inhibitor-cofactor binding pocket; inhibition site
1125630007653	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630007654	catalytic residue [active]
1125630007655	Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440
1125630007656	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
1125630007657	NAD(P) binding site [chemical binding]; other site
1125630007658	catalytic residues [active]
1125630007659	succinylarginine dihydrolase; Provisional; Region: PRK13281
1125630007660	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
1125630007661	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
1125630007662	active site
1125630007663	Zn binding site [ion binding]; other site
1125630007664	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
1125630007665	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
1125630007666	Domain of unknown function (DUF1980); Region: DUF1980; cl01492
1125630007667	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630007668	metabolite-proton symporter; Region: 2A0106; TIGR00883
1125630007669	putative substrate translocation pore; other site
1125630007670	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1125630007671	putative active site [active]
1125630007672	potential frameshift: common BLAST hit: gi|238894516|ref|YP_002919250.1| aldehyde dehydrogenase A
1125630007673	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1125630007674	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1125630007675	NAD(P) binding site [chemical binding]; other site
1125630007676	catalytic residues [active]
1125630007677	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
1125630007678	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1125630007679	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1125630007680	Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401
1125630007681	Protein of unknown function (DUF1398); Region: DUF1398; pfam07166
1125630007682	YedF is a bacterial SirA-like protein of unknown function.  SirA  (also known as UvrY,  and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422
1125630007683	CPxP  motif; other site
1125630007684	putative inner membrane protein; Provisional; Region: PRK11099
1125630007685	Predicted transporter component [General function prediction only]; Region: COG2391
1125630007686	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
1125630007687	putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318
1125630007688	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
1125630007689	metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459
1125630007690	oligomer interface [polypeptide binding]; other site
1125630007691	putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350
1125630007692	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1125630007693	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630007694	homodimer interface [polypeptide binding]; other site
1125630007695	catalytic residue [active]
1125630007696	bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110
1125630007697	PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852
1125630007698	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1125630007699	active site turn [active]
1125630007700	phosphorylation site [posttranslational modification]
1125630007701	DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014
1125630007702	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1125630007703	DNA binding site [nucleotide binding]
1125630007704	domain linker motif; other site
1125630007705	Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289
1125630007706	putative dimerization interface [polypeptide binding]; other site
1125630007707	putative ligand binding site [chemical binding]; other site
1125630007708	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
1125630007709	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
1125630007710	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
1125630007711	fumarate hydratase; Provisional; Region: PRK15389
1125630007712	Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951
1125630007713	Fumarase C-terminus; Region: Fumerase_C; pfam05683
1125630007714	fumarate hydratase; Reviewed; Region: fumC; PRK00485
1125630007715	Class II fumarases; Region: Fumarase_classII; cd01362
1125630007716	active site
1125630007717	tetramer interface [polypeptide binding]; other site
1125630007718	DNA replication terminus site-binding protein; Provisional; Region: PRK02951
1125630007719	sensor protein RstB; Provisional; Region: PRK10604
1125630007720	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1125630007721	dimerization interface [polypeptide binding]; other site
1125630007722	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1125630007723	dimer interface [polypeptide binding]; other site
1125630007724	phosphorylation site [posttranslational modification]
1125630007725	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1125630007726	ATP binding site [chemical binding]; other site
1125630007727	Mg2+ binding site [ion binding]; other site
1125630007728	G-X-G motif; other site
1125630007729	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
1125630007730	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1125630007731	active site
1125630007732	phosphorylation site [posttranslational modification]
1125630007733	intermolecular recognition site; other site
1125630007734	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1125630007735	DNA binding site [nucleotide binding]
1125630007736	GlpM protein; Region: GlpM; pfam06942
1125630007737	dihydromonapterin reductase; Provisional; Region: PRK06483
1125630007738	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1125630007739	NAD(P) binding site [chemical binding]; other site
1125630007740	active site
1125630007741	transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905
1125630007742	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
1125630007743	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
1125630007744	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
1125630007745	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
1125630007746	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
1125630007747	ligand binding site [chemical binding]; other site
1125630007748	homodimer interface [polypeptide binding]; other site
1125630007749	NAD(P) binding site [chemical binding]; other site
1125630007750	trimer interface B [polypeptide binding]; other site
1125630007751	trimer interface A [polypeptide binding]; other site
1125630007752	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
1125630007753	pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444
1125630007754	universal stress protein UspE; Provisional; Region: PRK11175
1125630007755	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1125630007756	Ligand Binding Site [chemical binding]; other site
1125630007757	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1125630007758	Ligand Binding Site [chemical binding]; other site
1125630007759	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
1125630007760	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1125630007761	ligand binding site [chemical binding]; other site
1125630007762	flexible hinge region; other site
1125630007763	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1125630007764	putative switch regulator; other site
1125630007765	non-specific DNA interactions [nucleotide binding]; other site
1125630007766	DNA binding site [nucleotide binding]
1125630007767	sequence specific DNA binding site [nucleotide binding]; other site
1125630007768	putative cAMP binding site [chemical binding]; other site
1125630007769	O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286
1125630007770	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
1125630007771	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1125630007772	DNA binding site [nucleotide binding]
1125630007773	active site
1125630007774	putative aminobenzoyl-glutamate transporter; Provisional; Region: abgT; PRK11339
1125630007775	M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673
1125630007776	amidohydrolase; Region: amidohydrolases; TIGR01891
1125630007777	putative metal binding site [ion binding]; other site
1125630007778	M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665
1125630007779	amidohydrolase; Region: amidohydrolases; TIGR01891
1125630007780	putative metal binding site [ion binding]; other site
1125630007781	dimer interface [polypeptide binding]; other site
1125630007782	putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791
1125630007783	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630007784	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1125630007785	dimerization interface [polypeptide binding]; other site
1125630007786	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
1125630007787	Smr domain; Region: Smr; pfam01713
1125630007788	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
1125630007789	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1125630007790	Bacterial transcriptional regulator; Region: IclR; pfam01614
1125630007791	3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429
1125630007792	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
1125630007793	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
1125630007794	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1125630007795	dimer interface [polypeptide binding]; other site
1125630007796	active site
1125630007797	3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053
1125630007798	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
1125630007799	tetramer interface [polypeptide binding]; other site
1125630007800	active site
1125630007801	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
1125630007802	Putative lysophospholipase; Region: Hydrolase_4; cl19140
1125630007803	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
1125630007804	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1125630007805	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1125630007806	fumarate hydratase FumB; Provisional; Region: PRK15391
1125630007807	Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951
1125630007808	Fumarase C-terminus; Region: Fumerase_C; pfam05683
1125630007809	Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939
1125630007810	anion transporter; Region: dass; TIGR00785
1125630007811	transmembrane helices; other site
1125630007812	potential frameshift: common BLAST hit: gi|238894567|ref|YP_002919301.1| putative NADH:flavin oxidoreductase
1125630007813	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
1125630007814	putative active site [active]
1125630007815	putative FMN binding site [chemical binding]; other site
1125630007816	putative substrate binding site [chemical binding]; other site
1125630007817	putative catalytic residue [active]
1125630007818	FMN-binding domain; Region: FMN_bind; cl01081
1125630007819	L-aspartate oxidase; Provisional; Region: PRK06175
1125630007820	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
1125630007821	DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430
1125630007822	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1125630007823	active site
1125630007824	phosphorylation site [posttranslational modification]
1125630007825	intermolecular recognition site; other site
1125630007826	dimerization interface [polypeptide binding]; other site
1125630007827	sensory histidine kinase DcuS; Provisional; Region: PRK11086
1125630007828	Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827
1125630007829	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1125630007830	putative active site [active]
1125630007831	heme pocket [chemical binding]; other site
1125630007832	Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689
1125630007833	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1125630007834	ATP binding site [chemical binding]; other site
1125630007835	Mg2+ binding site [ion binding]; other site
1125630007836	G-X-G motif; other site
1125630007837	N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274
1125630007838	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
1125630007839	putative active site [active]
1125630007840	malate:quinone oxidoreductase; Validated; Region: PRK05257
1125630007841	Predicted dehydrogenase [General function prediction only]; Region: COG0579
1125630007842	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630007843	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630007844	The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416
1125630007845	putative dimerization interface [polypeptide binding]; other site
1125630007846	malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131
1125630007847	phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293
1125630007848	he Auxin Efflux Carrier (AEC) Family; Region: 2a69; TIGR00946
1125630007849	Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; pfam06833
1125630007850	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189
1125630007851	Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082
1125630007852	ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768
1125630007853	malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110
1125630007854	Coenzyme A transferase; Region: CoA_trans; cl17247
1125630007855	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287
1125630007856	multidrug efflux system protein MdtJ; Provisional; Region: PRK10452
1125630007857	multidrug efflux system protein MdtI; Provisional; Region: PRK10650
1125630007858	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
1125630007859	acid shock protein precursor; Provisional; Region: PRK03577
1125630007860	potential frameshift: common BLAST hit: gi|238894592|ref|YP_002919326.1| putative Zn-dependent carboxypeptidase
1125630007861	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
1125630007862	active site
1125630007863	Zn binding site [ion binding]; other site
1125630007864	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
1125630007865	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1125630007866	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630007867	putative substrate translocation pore; other site
1125630007868	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
1125630007869	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630007870	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
1125630007871	dimerization interface [polypeptide binding]; other site
1125630007872	substrate binding pocket [chemical binding]; other site
1125630007873	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
1125630007874	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1125630007875	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1125630007876	nucleotide binding site [chemical binding]; other site
1125630007877	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1125630007878	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1125630007879	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
1125630007880	Cl- selectivity filter; other site
1125630007881	Cl- binding residues [ion binding]; other site
1125630007882	pore gating glutamate residue; other site
1125630007883	dimer interface [polypeptide binding]; other site
1125630007884	twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621
1125630007885	potential frameshift: common BLAST hit: gi|152970130|ref|YP_001335239.1| putative dimethyl sulfoxide reductase, anchor subunit
1125630007886	DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302
1125630007887	DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519
1125630007888	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
1125630007889	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
1125630007890	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
1125630007891	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
1125630007892	putative [Fe4-S4] binding site [ion binding]; other site
1125630007893	putative molybdopterin cofactor binding site [chemical binding]; other site
1125630007894	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
1125630007895	putative molybdopterin cofactor binding site; other site
1125630007896	Protein of unknown function (DUF1161); Region: DUF1161; pfam06649
1125630007897	lipoprotein; Reviewed; Region: PRK02939
1125630007898	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1125630007899	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1125630007900	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1125630007901	Coenzyme A binding pocket [chemical binding]; other site
1125630007902	hypothetical protein; Provisional; Region: PRK13659
1125630007903	hypothetical protein; Provisional; Region: PRK02237
1125630007904	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630007905	D-galactonate transporter; Region: 2A0114; TIGR00893
1125630007906	putative substrate translocation pore; other site
1125630007907	D-mannonate oxidoreductase; Provisional; Region: PRK15037
1125630007908	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1125630007909	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1125630007910	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1125630007911	Ligand Binding Site [chemical binding]; other site
1125630007912	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1125630007913	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1125630007914	DNA-binding site [nucleotide binding]; DNA binding site
1125630007915	FCD domain; Region: FCD; pfam07729
1125630007916	malonic semialdehyde reductase; Provisional; Region: PRK10538
1125630007917	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
1125630007918	putative NAD(P) binding site [chemical binding]; other site
1125630007919	homodimer interface [polypeptide binding]; other site
1125630007920	homotetramer interface [polypeptide binding]; other site
1125630007921	active site
1125630007922	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
1125630007923	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
1125630007924	active site
1125630007925	Zn binding site [ion binding]; other site
1125630007926	hypothetical protein; Provisional; Region: PRK09951
1125630007927	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1125630007928	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1125630007929	DNA binding residues [nucleotide binding]
1125630007930	dimerization interface [polypeptide binding]; other site
1125630007931	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1125630007932	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
1125630007933	putative dimer interface [polypeptide binding]; other site
1125630007934	hypothetical protein; Validated; Region: PRK03657
1125630007935	Sensors of blue-light using FAD; Region: BLUF; smart01034
1125630007936	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1125630007937	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1125630007938	DNA binding residues [nucleotide binding]
1125630007939	dimerization interface [polypeptide binding]; other site
1125630007940	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1125630007941	right oriC-binding transcriptional activator; Provisional; Region: PRK15121
1125630007942	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630007943	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
1125630007944	putative transporter; Provisional; Region: PRK09821
1125630007945	GntP family permease; Region: GntP_permease; pfam02447
1125630007946	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
1125630007947	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
1125630007948	putative aldolase; Validated; Region: PRK08130
1125630007949	intersubunit interface [polypeptide binding]; other site
1125630007950	active site
1125630007951	Zn2+ binding site [ion binding]; other site
1125630007952	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
1125630007953	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1125630007954	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
1125630007955	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833
1125630007956	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1125630007957	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1125630007958	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1125630007959	beta-lactamase TEM; Provisional; Region: PRK15442
1125630007960	Predicted ATPase [General function prediction only]; Region: COG4637
1125630007961	AAA domain; Region: AAA_23; pfam13476
1125630007962	Walker A/P-loop; other site
1125630007963	ATP binding site [chemical binding]; other site
1125630007964	ABC transporter signature motif; other site
1125630007965	AAA domain; Region: AAA_21; pfam13304
1125630007966	Walker B; other site
1125630007967	D-loop; other site
1125630007968	H-loop/switch region; other site
1125630007969	LacY proton/sugar symporter; Region: LacY_symp; pfam01306
1125630007970	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630007971	putative substrate translocation pore; other site
1125630007972	potential frameshift: common BLAST hit: gi|238894637|ref|YP_002919371.1| beta-D-galactosidase
1125630007973	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1125630007974	Beta galactosidase small chain; Region: Bgal_small_N; pfam02929
1125630007975	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1125630007976	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1125630007977	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1125630007978	lac repressor; Reviewed; Region: lacI; PRK09526
1125630007979	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1125630007980	DNA binding site [nucleotide binding]
1125630007981	domain linker motif; other site
1125630007982	Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574
1125630007983	ligand binding site [chemical binding]; other site
1125630007984	dimerization interface (open form) [polypeptide binding]; other site
1125630007985	dimerization interface (closed form) [polypeptide binding]; other site
1125630007986	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1125630007987	Coenzyme A binding pocket [chemical binding]; other site
1125630007988	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
1125630007989	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
1125630007990	conserved cys residue [active]
1125630007991	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630007992	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630007993	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1125630007994	active site residue [active]
1125630007995	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
1125630007996	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1125630007997	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1125630007998	substrate binding site [chemical binding]; other site
1125630007999	THF binding site; other site
1125630008000	zinc-binding site [ion binding]; other site
1125630008001	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
1125630008002	Receptor family ligand binding region; Region: ANF_receptor; pfam01094
1125630008003	putative ligand binding site [chemical binding]; other site
1125630008004	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1125630008005	TM-ABC transporter signature motif; other site
1125630008006	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1125630008007	TM-ABC transporter signature motif; other site
1125630008008	Uncharacterized ABC-type transport system, ATPase component [General function prediction only]; Region: COG4674
1125630008009	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1125630008010	Walker A/P-loop; other site
1125630008011	ATP binding site [chemical binding]; other site
1125630008012	Q-loop/lid; other site
1125630008013	ABC transporter signature motif; other site
1125630008014	Walker B; other site
1125630008015	D-loop; other site
1125630008016	H-loop/switch region; other site
1125630008017	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
1125630008018	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1125630008019	Walker A/P-loop; other site
1125630008020	ATP binding site [chemical binding]; other site
1125630008021	Q-loop/lid; other site
1125630008022	ABC transporter signature motif; other site
1125630008023	Walker B; other site
1125630008024	D-loop; other site
1125630008025	H-loop/switch region; other site
1125630008026	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1125630008027	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1125630008028	non-specific DNA binding site [nucleotide binding]; other site
1125630008029	salt bridge; other site
1125630008030	sequence-specific DNA binding site [nucleotide binding]; other site
1125630008031	2TM domain; Region: 2TM; pfam13239
1125630008032	putative transporter; Provisional; Region: PRK10054
1125630008033	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630008034	putative substrate translocation pore; other site
1125630008035	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
1125630008036	EamA-like transporter family; Region: EamA; pfam00892
1125630008037	MarB protein; Region: MarB; pfam13999
1125630008038	DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511
1125630008039	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630008040	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630008041	DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512
1125630008042	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1125630008043	inner membrane protein; Provisional; Region: PRK10995
1125630008044	putative arabinose transporter; Provisional; Region: PRK03545
1125630008045	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630008046	putative substrate translocation pore; other site
1125630008047	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
1125630008048	Diaminopimelate epimerase; Region: DAP_epimerase; cl19724
1125630008049	short chain dehydrogenase; Provisional; Region: PRK07577
1125630008050	classical (c) SDRs; Region: SDR_c; cd05233
1125630008051	NAD(P) binding site [chemical binding]; other site
1125630008052	active site
1125630008053	Domain of unknown function (DUF386); Region: DUF386; cl01047
1125630008054	Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692
1125630008055	BNR repeat-like domain; Region: BNR_2; pfam13088
1125630008056	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
1125630008057	Na binding site [ion binding]; other site
1125630008058	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1125630008059	inhibitor site; inhibition site
1125630008060	active site
1125630008061	dimer interface [polypeptide binding]; other site
1125630008062	catalytic residue [active]
1125630008063	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
1125630008064	active site
1125630008065	NAD binding site [chemical binding]; other site
1125630008066	metal binding site [ion binding]; metal-binding site
1125630008067	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
1125630008068	4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371
1125630008069	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1125630008070	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1125630008071	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1125630008072	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
1125630008073	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1125630008074	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
1125630008075	NAD binding site [chemical binding]; other site
1125630008076	dimer interface [polypeptide binding]; other site
1125630008077	substrate binding site [chemical binding]; other site
1125630008078	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1125630008079	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1125630008080	Coenzyme A binding pocket [chemical binding]; other site
1125630008081	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630008082	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630008083	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
1125630008084	putative dimerization interface [polypeptide binding]; other site
1125630008085	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
1125630008086	NAD(P) binding site [chemical binding]; other site
1125630008087	catalytic residues [active]
1125630008088	glutaminase; Provisional; Region: PRK00971
1125630008089	Domain of unknown function (DUF4186); Region: DUF4186; pfam13811
1125630008090	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1125630008091	metal binding site [ion binding]; metal-binding site
1125630008092	active site
1125630008093	I-site; other site
1125630008094	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1125630008095	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1125630008096	Coenzyme A binding pocket [chemical binding]; other site
1125630008097	altronate oxidoreductase; Provisional; Region: PRK03643
1125630008098	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1125630008099	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1125630008100	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1125630008101	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1125630008102	Coenzyme A binding pocket [chemical binding]; other site
1125630008103	Tautomerase enzyme; Region: Tautomerase_2; pfam14552
1125630008104	Tautomerase enzyme; Region: Tautomerase_2; pfam14552
1125630008105	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
1125630008106	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
1125630008107	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1125630008108	S-adenosylmethionine binding site [chemical binding]; other site
1125630008109	major facilitator superfamily transporter; Provisional; Region: PRK05122
1125630008110	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630008111	putative substrate translocation pore; other site
1125630008112	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1125630008113	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1125630008114	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630008115	putative substrate translocation pore; other site
1125630008116	potential frameshift: common BLAST hit: gi|238894689|ref|YP_002919423.1| LysR family transcriptional regulator
1125630008117	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1125630008118	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630008119	dimerization interface [polypeptide binding]; other site
1125630008120	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630008121	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630008122	Nitronate monooxygenase; Region: NMO; pfam03060
1125630008123	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1125630008124	FMN binding site [chemical binding]; other site
1125630008125	substrate binding site [chemical binding]; other site
1125630008126	putative catalytic residue [active]
1125630008127	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630008128	dimer interface [polypeptide binding]; other site
1125630008129	conserved gate region; other site
1125630008130	putative PBP binding loops; other site
1125630008131	ABC-ATPase subunit interface; other site
1125630008132	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1125630008133	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1125630008134	Walker A/P-loop; other site
1125630008135	ATP binding site [chemical binding]; other site
1125630008136	Q-loop/lid; other site
1125630008137	ABC transporter signature motif; other site
1125630008138	Walker B; other site
1125630008139	D-loop; other site
1125630008140	H-loop/switch region; other site
1125630008141	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1125630008142	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
1125630008143	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
1125630008144	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
1125630008145	Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905
1125630008146	Cupin domain; Region: Cupin_2; cl17218
1125630008147	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
1125630008148	Cupin; Region: Cupin_6; pfam12852
1125630008149	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1125630008150	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630008151	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630008152	ribonucleoside transporter; Reviewed; Region: nepI; PRK10213
1125630008153	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630008154	putative substrate translocation pore; other site
1125630008155	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
1125630008156	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1125630008157	FMN-binding pocket [chemical binding]; other site
1125630008158	flavin binding motif; other site
1125630008159	phosphate binding motif [ion binding]; other site
1125630008160	beta-alpha-beta structure motif; other site
1125630008161	NAD binding pocket [chemical binding]; other site
1125630008162	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1125630008163	catalytic loop [active]
1125630008164	iron binding site [ion binding]; other site
1125630008165	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1125630008166	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
1125630008167	[2Fe-2S] cluster binding site [ion binding]; other site
1125630008168	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1125630008169	hydrophobic ligand binding site; other site
1125630008170	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630008171	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630008172	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1125630008173	dimerization interface [polypeptide binding]; other site
1125630008174	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1125630008175	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
1125630008176	Sulfate transporter family; Region: Sulfate_transp; cl19250
1125630008177	xanthine permease; Region: pbuX; TIGR03173
1125630008178	OHCU decarboxylase; Region: UraD_2; TIGR03180
1125630008179	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
1125630008180	active site
1125630008181	homotetramer interface [polypeptide binding]; other site
1125630008182	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1125630008183	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1125630008184	non-specific DNA binding site [nucleotide binding]; other site
1125630008185	salt bridge; other site
1125630008186	sequence-specific DNA binding site [nucleotide binding]; other site
1125630008187	HipA N-terminal domain; Region: Couple_hipA; pfam13657
1125630008188	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
1125630008189	HipA-like N-terminal domain; Region: HipA_N; pfam07805
1125630008190	HipA-like C-terminal domain; Region: HipA_C; pfam07804
1125630008191	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
1125630008192	active site
1125630008193	potential frameshift: common BLAST hit: gi|288935520|ref|YP_003439579.1| fimbrial protein
1125630008194	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
1125630008195	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
1125630008196	PapC N-terminal domain; Region: PapC_N; pfam13954
1125630008197	Outer membrane usher protein; Region: Usher; pfam00577
1125630008198	PapC C-terminal domain; Region: PapC_C; pfam13953
1125630008199	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
1125630008200	Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345
1125630008201	Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753
1125630008202	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
1125630008203	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1125630008204	active site
1125630008205	Protein of unknown function (DUF3423); Region: DUF3423; pfam11903
1125630008206	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1125630008207	PAS domain; Region: PAS_9; pfam13426
1125630008208	putative active site [active]
1125630008209	heme pocket [chemical binding]; other site
1125630008210	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1125630008211	metal binding site [ion binding]; metal-binding site
1125630008212	active site
1125630008213	I-site; other site
1125630008214	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1125630008215	potential frameshift: common BLAST hit: gi|152970230|ref|YP_001335339.1| putative oxidoreductase, Fe-S subunit
1125630008216	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1125630008217	Mannitol/fructose-specific phosphotransferase system, IIA domain [Carbohydrate transport and metabolism]; Region: MtlA; COG4668
1125630008218	active site
1125630008219	phosphorylation site [posttranslational modification]
1125630008220	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
1125630008221	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630008222	putative substrate translocation pore; other site
1125630008223	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
1125630008224	Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298
1125630008225	NAD binding site [chemical binding]; other site
1125630008226	sugar binding site [chemical binding]; other site
1125630008227	divalent metal binding site [ion binding]; other site
1125630008228	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
1125630008229	dimer interface [polypeptide binding]; other site
1125630008230	PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005
1125630008231	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1125630008232	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1125630008233	active site turn [active]
1125630008234	phosphorylation site [posttranslational modification]
1125630008235	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1125630008236	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1125630008237	DNA-binding site [nucleotide binding]; DNA binding site
1125630008238	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1125630008239	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1125630008240	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630008241	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630008242	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1125630008243	dimerization interface [polypeptide binding]; other site
1125630008244	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1125630008245	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
1125630008246	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833
1125630008247	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
1125630008248	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
1125630008249	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1125630008250	Glycerate kinase family; Region: Gly_kinase; cl00841
1125630008251	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630008252	putative substrate translocation pore; other site
1125630008253	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1125630008254	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
1125630008255	potential frameshift: common BLAST hit: gi|238894737|ref|YP_002919471.1| major facilitator family transporter
1125630008256	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630008257	putative substrate translocation pore; other site
1125630008258	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630008259	putative acyltransferase; Provisional; Region: PRK05790
1125630008260	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1125630008261	dimer interface [polypeptide binding]; other site
1125630008262	active site
1125630008263	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1125630008264	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1125630008265	NAD(P) binding site [chemical binding]; other site
1125630008266	active site
1125630008267	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
1125630008268	Coenzyme A transferase; Region: CoA_trans; smart00882
1125630008269	Coenzyme A transferase; Region: CoA_trans; cl17247
1125630008270	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1125630008271	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1125630008272	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
1125630008273	acyl-activating enzyme (AAE) consensus motif; other site
1125630008274	acyl-activating enzyme (AAE) consensus motif; other site
1125630008275	putative AMP binding site [chemical binding]; other site
1125630008276	putative active site [active]
1125630008277	putative CoA binding site [chemical binding]; other site
1125630008278	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1125630008279	active site
1125630008280	metal binding site [ion binding]; metal-binding site
1125630008281	potential frameshift: common BLAST hit: gi|152970250|ref|YP_001335359.1| fucose permease
1125630008282	L-fucose transporter; Provisional; Region: PRK10133; cl17665
1125630008283	L-fucose transporter; Provisional; Region: PRK10133; cl17665
1125630008284	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1125630008285	substrate binding site [chemical binding]; other site
1125630008286	dimer interface [polypeptide binding]; other site
1125630008287	ATP binding site [chemical binding]; other site
1125630008288	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1125630008289	substrate binding site [chemical binding]; other site
1125630008290	hexamer interface [polypeptide binding]; other site
1125630008291	metal binding site [ion binding]; metal-binding site
1125630008292	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1125630008293	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1125630008294	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1125630008295	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1125630008296	intersubunit interface [polypeptide binding]; other site
1125630008297	active site
1125630008298	catalytic residue [active]
1125630008299	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
1125630008300	D-xylulose kinases, subgroup 3; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_3; cd07811
1125630008301	putative N- and C-terminal domain interface [polypeptide binding]; other site
1125630008302	putative active site [active]
1125630008303	putative MgATP binding site [chemical binding]; other site
1125630008304	catalytic site [active]
1125630008305	metal binding site [ion binding]; metal-binding site
1125630008306	putative xylulose binding site [chemical binding]; other site
1125630008307	putative homodimer interface [polypeptide binding]; other site
1125630008308	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1125630008309	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1125630008310	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1125630008311	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
1125630008312	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1125630008313	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630008314	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
1125630008315	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
1125630008316	Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; pfam10012
1125630008317	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1125630008318	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
1125630008319	conserved cys residue [active]
1125630008320	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630008321	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630008322	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
1125630008323	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1125630008324	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1125630008325	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1125630008326	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
1125630008327	active site
1125630008328	catalytic tetrad [active]
1125630008329	potential frameshift: common BLAST hit: gi|254559960|ref|YP_003067055.1| lactonase
1125630008330	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
1125630008331	Strictosidine synthase; Region: Str_synth; cl19733
1125630008332	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1125630008333	active site
1125630008334	catalytic tetrad [active]
1125630008335	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1125630008336	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
1125630008337	active site
1125630008338	catalytic tetrad [active]
1125630008339	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630008340	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630008341	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
1125630008342	putative effector binding pocket; other site
1125630008343	putative dimerization interface [polypeptide binding]; other site
1125630008344	GrpB protein; Region: GrpB; pfam04229
1125630008345	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1125630008346	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1125630008347	active site
1125630008348	phosphorylation site [posttranslational modification]
1125630008349	intermolecular recognition site; other site
1125630008350	dimerization interface [polypeptide binding]; other site
1125630008351	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944
1125630008352	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1125630008353	Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192
1125630008354	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
1125630008355	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1125630008356	dimer interface [polypeptide binding]; other site
1125630008357	phosphorylation site [posttranslational modification]
1125630008358	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1125630008359	ATP binding site [chemical binding]; other site
1125630008360	Mg2+ binding site [ion binding]; other site
1125630008361	G-X-G motif; other site
1125630008362	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1125630008363	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630008364	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
1125630008365	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1125630008366	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630008367	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
1125630008368	BON domain; Region: BON; pfam04972
1125630008369	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1125630008370	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
1125630008371	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
1125630008372	Predicted TIM-barrel enzyme [General function prediction only]; Region: SgcQ; COG0434
1125630008373	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1125630008374	substrate binding site [chemical binding]; other site
1125630008375	ATP binding site [chemical binding]; other site
1125630008376	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1125630008377	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
1125630008378	ligand binding site [chemical binding]; other site
1125630008379	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1125630008380	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1125630008381	DNA binding site [nucleotide binding]
1125630008382	domain linker motif; other site
1125630008383	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_11; cd06293
1125630008384	putative dimerization interface [polypeptide binding]; other site
1125630008385	putative ligand binding site [chemical binding]; other site
1125630008386	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1125630008387	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
1125630008388	Walker A/P-loop; other site
1125630008389	ATP binding site [chemical binding]; other site
1125630008390	Q-loop/lid; other site
1125630008391	ABC transporter signature motif; other site
1125630008392	Walker B; other site
1125630008393	D-loop; other site
1125630008394	H-loop/switch region; other site
1125630008395	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1125630008396	TM-ABC transporter signature motif; other site
1125630008397	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
1125630008398	active site
1125630008399	substrate binding pocket [chemical binding]; other site
1125630008400	homodimer interaction site [polypeptide binding]; other site
1125630008401	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
1125630008402	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588
1125630008403	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
1125630008404	metal binding site [ion binding]; metal-binding site
1125630008405	dimer interface [polypeptide binding]; other site
1125630008406	TolA C-terminal; Region: TolA; pfam06519
1125630008407	TolA protein; Region: tolA_full; TIGR02794
1125630008408	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1125630008409	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630008410	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630008411	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1125630008412	putative effector binding pocket; other site
1125630008413	dimerization interface [polypeptide binding]; other site
1125630008414	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630008415	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630008416	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1125630008417	putative effector binding pocket; other site
1125630008418	dimerization interface [polypeptide binding]; other site
1125630008419	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630008420	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1125630008421	putative substrate translocation pore; other site
1125630008422	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1125630008423	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1125630008424	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
1125630008425	active site
1125630008426	P-loop; other site
1125630008427	phosphorylation site [posttranslational modification]
1125630008428	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1125630008429	active site
1125630008430	phosphorylation site [posttranslational modification]
1125630008431	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1125630008432	substrate binding site [chemical binding]; other site
1125630008433	hexamer interface [polypeptide binding]; other site
1125630008434	metal binding site [ion binding]; metal-binding site
1125630008435	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
1125630008436	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
1125630008437	active site
1125630008438	P-loop; other site
1125630008439	phosphorylation site [posttranslational modification]
1125630008440	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1125630008441	active site
1125630008442	phosphorylation site [posttranslational modification]
1125630008443	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1125630008444	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1125630008445	DNA binding site [nucleotide binding]
1125630008446	domain linker motif; other site
1125630008447	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
1125630008448	putative dimerization interface [polypeptide binding]; other site
1125630008449	putative ligand binding site [chemical binding]; other site
1125630008450	oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259
1125630008451	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630008452	putative substrate translocation pore; other site
1125630008453	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1125630008454	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1125630008455	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1125630008456	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1125630008457	Iron-containing redox enzyme; Region: Haem_oxygenas_2; pfam14518
1125630008458	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1125630008459	EamA-like transporter family; Region: EamA; pfam00892
1125630008460	EamA-like transporter family; Region: EamA; pfam00892
1125630008461	putative sialic acid transporter; Region: 2A0112; TIGR00891
1125630008462	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630008463	putative substrate translocation pore; other site
1125630008464	hypothetical protein; Provisional; Region: PRK09897
1125630008465	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
1125630008466	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1125630008467	phosphate binding site [ion binding]; other site
1125630008468	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630008469	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630008470	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
1125630008471	putative effector binding pocket; other site
1125630008472	putative dimerization interface [polypeptide binding]; other site
1125630008473	Nitronate monooxygenase; Region: NMO; pfam03060
1125630008474	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1125630008475	FMN binding site [chemical binding]; other site
1125630008476	substrate binding site [chemical binding]; other site
1125630008477	putative catalytic residue [active]
1125630008478	allantoate amidohydrolase; Reviewed; Region: PRK09290
1125630008479	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
1125630008480	active site
1125630008481	metal binding site [ion binding]; metal-binding site
1125630008482	dimer interface [polypeptide binding]; other site
1125630008483	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
1125630008484	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1125630008485	catalytic residue [active]
1125630008486	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1125630008487	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1125630008488	Walker A/P-loop; other site
1125630008489	ATP binding site [chemical binding]; other site
1125630008490	Q-loop/lid; other site
1125630008491	ABC transporter signature motif; other site
1125630008492	Walker B; other site
1125630008493	D-loop; other site
1125630008494	H-loop/switch region; other site
1125630008495	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
1125630008496	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630008497	dimer interface [polypeptide binding]; other site
1125630008498	conserved gate region; other site
1125630008499	putative PBP binding loops; other site
1125630008500	ABC-ATPase subunit interface; other site
1125630008501	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
1125630008502	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630008503	dimer interface [polypeptide binding]; other site
1125630008504	conserved gate region; other site
1125630008505	putative PBP binding loops; other site
1125630008506	ABC-ATPase subunit interface; other site
1125630008507	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1125630008508	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1125630008509	substrate binding pocket [chemical binding]; other site
1125630008510	membrane-bound complex binding site; other site
1125630008511	hinge residues; other site
1125630008512	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1125630008513	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1125630008514	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1125630008515	putative active site [active]
1125630008516	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
1125630008517	Protein of unknown function (DUF4089); Region: DUF4089; pfam13318
1125630008518	potential frameshift: common BLAST hit: gi|238894806|ref|YP_002919540.1| amidase
1125630008519	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl18951
1125630008520	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl18951
1125630008521	Protein of unknown function (DUF3225); Region: DUF3225; pfam11533
1125630008522	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1125630008523	Coenzyme A binding pocket [chemical binding]; other site
1125630008524	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
1125630008525	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1125630008526	Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774
1125630008527	Predicted transcriptional regulators [Transcription]; Region: COG1733
1125630008528	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
1125630008529	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1125630008530	HlyD family secretion protein; Region: HlyD_3; pfam13437
1125630008531	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1125630008532	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630008533	putative substrate translocation pore; other site
1125630008534	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333
1125630008535	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1125630008536	dimer interface [polypeptide binding]; other site
1125630008537	active site
1125630008538	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
1125630008539	Helix-turn-helix domain; Region: HTH_18; pfam12833
1125630008540	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630008541	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
1125630008542	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
1125630008543	catalytic triad [active]
1125630008544	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1125630008545	catalytic triad [active]
1125630008546	conserved cis-peptide bond; other site
1125630008547	Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300
1125630008548	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1125630008549	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1125630008550	Helix-turn-helix domain; Region: HTH_18; pfam12833
1125630008551	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630008552	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1125630008553	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
1125630008554	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
1125630008555	active site
1125630008556	catalytic site [active]
1125630008557	tetramer interface [polypeptide binding]; other site
1125630008558	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
1125630008559	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1125630008560	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1125630008561	DNA-binding site [nucleotide binding]; DNA binding site
1125630008562	FCD domain; Region: FCD; pfam07729
1125630008563	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555
1125630008564	Na binding site [ion binding]; other site
1125630008565	putative substrate binding site [chemical binding]; other site
1125630008566	guanine deaminase; Provisional; Region: PRK09228
1125630008567	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
1125630008568	active site
1125630008569	PAS domain; Region: PAS_9; pfam13426
1125630008570	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1125630008571	putative active site [active]
1125630008572	heme pocket [chemical binding]; other site
1125630008573	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1125630008574	metal binding site [ion binding]; metal-binding site
1125630008575	active site
1125630008576	I-site; other site
1125630008577	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1125630008578	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1125630008579	DNA binding site [nucleotide binding]
1125630008580	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1125630008581	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1125630008582	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1125630008583	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
1125630008584	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1125630008585	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1125630008586	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1125630008587	Protein of unknown function (DUF4056); Region: DUF4056; pfam13265
1125630008588	Putative transcription activator [Transcription]; Region: TenA; COG0819
1125630008589	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1125630008590	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1125630008591	Walker A/P-loop; other site
1125630008592	ATP binding site [chemical binding]; other site
1125630008593	Q-loop/lid; other site
1125630008594	ABC transporter signature motif; other site
1125630008595	Walker B; other site
1125630008596	D-loop; other site
1125630008597	H-loop/switch region; other site
1125630008598	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1125630008599	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630008600	dimer interface [polypeptide binding]; other site
1125630008601	conserved gate region; other site
1125630008602	putative PBP binding loops; other site
1125630008603	ABC-ATPase subunit interface; other site
1125630008604	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1125630008605	NMT1/THI5 like; Region: NMT1; pfam09084
1125630008606	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1125630008607	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
1125630008608	inhibitor-cofactor binding pocket; inhibition site
1125630008609	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630008610	catalytic residue [active]
1125630008611	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
1125630008612	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630008613	catalytic residue [active]
1125630008614	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630008615	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630008616	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1125630008617	dimerization interface [polypeptide binding]; other site
1125630008618	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1125630008619	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1125630008620	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1125630008621	dimerization interface [polypeptide binding]; other site
1125630008622	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1125630008623	dimer interface [polypeptide binding]; other site
1125630008624	phosphorylation site [posttranslational modification]
1125630008625	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1125630008626	ATP binding site [chemical binding]; other site
1125630008627	Mg2+ binding site [ion binding]; other site
1125630008628	G-X-G motif; other site
1125630008629	osmolarity response regulator; Provisional; Region: ompR; PRK09468
1125630008630	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1125630008631	active site
1125630008632	phosphorylation site [posttranslational modification]
1125630008633	intermolecular recognition site; other site
1125630008634	dimerization interface [polypeptide binding]; other site
1125630008635	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1125630008636	DNA binding site [nucleotide binding]
1125630008637	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1125630008638	Putative lysophospholipase; Region: Hydrolase_4; cl19140
1125630008639	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
1125630008640	active site
1125630008641	dimer interface [polypeptide binding]; other site
1125630008642	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
1125630008643	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
1125630008644	pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079
1125630008645	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
1125630008646	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1125630008647	FeS/SAM binding site; other site
1125630008648	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
1125630008649	potential frameshift: common BLAST hit: gi|238894849|ref|YP_002919583.1| pyrroloquinoline quinone synthesis protein F
1125630008650	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1125630008651	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1125630008652	coenzyme PQQ biosynthesis probable peptidase PqqF; Region: PQQ_syn_pqqF; TIGR02110
1125630008653	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
1125630008654	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
1125630008655	catalytic triad [active]
1125630008656	penicillin-binding protein 2; Provisional; Region: PRK10795
1125630008657	Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717
1125630008658	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1125630008659	Protein of unknown function, DUF606; Region: DUF606; pfam04657
1125630008660	Protein of unknown function, DUF606; Region: DUF606; pfam04657
1125630008661	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630008662	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630008663	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1125630008664	putative effector binding pocket; other site
1125630008665	dimerization interface [polypeptide binding]; other site
1125630008666	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
1125630008667	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
1125630008668	heme binding site [chemical binding]; other site
1125630008669	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
1125630008670	potential frameshift: common BLAST hit: gi|152970372|ref|YP_001335481.1| putative ATPase
1125630008671	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944
1125630008672	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944
1125630008673	magnesium transport protein MgtC; Provisional; Region: PRK15385
1125630008674	MgtC family; Region: MgtC; pfam02308
1125630008675	benzoate transport; Region: 2A0115; TIGR00895
1125630008676	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630008677	putative substrate translocation pore; other site
1125630008678	methionine cluster; other site
1125630008679	PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255
1125630008680	active site
1125630008681	phosphorylation site [posttranslational modification]
1125630008682	metal binding site [ion binding]; metal-binding site
1125630008683	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
1125630008684	active site
1125630008685	P-loop; other site
1125630008686	phosphorylation site [posttranslational modification]
1125630008687	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
1125630008688	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1125630008689	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1125630008690	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1125630008691	Helix-turn-helix domain; Region: HTH_18; pfam12833
1125630008692	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
1125630008693	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
1125630008694	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1125630008695	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630008696	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630008697	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1125630008698	dimerization interface [polypeptide binding]; other site
1125630008699	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
1125630008700	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
1125630008701	putative molybdopterin cofactor binding site [chemical binding]; other site
1125630008702	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
1125630008703	putative molybdopterin cofactor binding site; other site
1125630008704	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544
1125630008705	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1125630008706	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1125630008707	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1125630008708	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1125630008709	substrate binding pocket [chemical binding]; other site
1125630008710	membrane-bound complex binding site; other site
1125630008711	hinge residues; other site
1125630008712	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
1125630008713	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
1125630008714	hypothetical protein; Provisional; Region: PRK10053
1125630008715	Predicted membrane protein [Function unknown]; Region: COG2323
1125630008716	potential frameshift: common BLAST hit: gi|152970389|ref|YP_001335498.1| putative oxidoreductase
1125630008717	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1125630008718	short chain dehydrogenase; Region: adh_short; pfam00106
1125630008719	NAD(P) binding site [chemical binding]; other site
1125630008720	active site
1125630008721	potential frameshift: common BLAST hit: gi|152970389|ref|YP_001335498.1| putative oxidoreductase
1125630008722	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1125630008723	trehalose synthase; Region: treS_nterm; TIGR02456
1125630008724	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
1125630008725	active site
1125630008726	catalytic site [active]
1125630008727	Domain of unknown function (DUF892); Region: DUF892; pfam05974
1125630008728	General stress protein [General function prediction only]; Region: GsiB; COG3729
1125630008729	oxidoreductase; Provisional; Region: PRK06128
1125630008730	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
1125630008731	NAD binding site [chemical binding]; other site
1125630008732	metal binding site [ion binding]; metal-binding site
1125630008733	active site
1125630008734	Protein of unknown function (DUF2543); Region: DUF2543; pfam10820
1125630008735	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630008736	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630008737	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1125630008738	putative effector binding pocket; other site
1125630008739	dimerization interface [polypeptide binding]; other site
1125630008740	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1125630008741	30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057
1125630008742	malate dehydrogenase; Provisional; Region: PRK13529
1125630008743	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1125630008744	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
1125630008745	NAD(P) binding site [chemical binding]; other site
1125630008746	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
1125630008747	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1125630008748	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1125630008749	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1125630008750	potential frameshift: common BLAST hit: gi|152970403|ref|YP_001335512.1| putative regulatory protein MarR
1125630008751	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1125630008752	Coenzyme A binding pocket [chemical binding]; other site
1125630008753	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1125630008754	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1125630008755	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
1125630008756	dimer interface [polypeptide binding]; other site
1125630008757	substrate binding site [chemical binding]; other site
1125630008758	metal binding sites [ion binding]; metal-binding site
1125630008759	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
1125630008760	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
1125630008761	NAD binding site [chemical binding]; other site
1125630008762	substrate binding site [chemical binding]; other site
1125630008763	catalytic Zn binding site [ion binding]; other site
1125630008764	tetramer interface [polypeptide binding]; other site
1125630008765	structural Zn binding site [ion binding]; other site
1125630008766	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1125630008767	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492
1125630008768	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1125630008769	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630008770	dimer interface [polypeptide binding]; other site
1125630008771	conserved gate region; other site
1125630008772	putative PBP binding loops; other site
1125630008773	ABC-ATPase subunit interface; other site
1125630008774	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1125630008775	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630008776	dimer interface [polypeptide binding]; other site
1125630008777	conserved gate region; other site
1125630008778	putative PBP binding loops; other site
1125630008779	ABC-ATPase subunit interface; other site
1125630008780	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1125630008781	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1125630008782	Walker A/P-loop; other site
1125630008783	ATP binding site [chemical binding]; other site
1125630008784	Q-loop/lid; other site
1125630008785	ABC transporter signature motif; other site
1125630008786	Walker B; other site
1125630008787	D-loop; other site
1125630008788	H-loop/switch region; other site
1125630008789	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1125630008790	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1125630008791	Walker A/P-loop; other site
1125630008792	ATP binding site [chemical binding]; other site
1125630008793	Q-loop/lid; other site
1125630008794	ABC transporter signature motif; other site
1125630008795	Walker B; other site
1125630008796	D-loop; other site
1125630008797	H-loop/switch region; other site
1125630008798	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1125630008799	putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027
1125630008800	CMD domain protein, Avi_7170 family; Region: CMD_Avi_7170; TIGR04029
1125630008801	alkylhydroperoxidase domain protein, Avi_7169 family; Region: perox_Avi_7169; TIGR04030
1125630008802	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1125630008803	MFS transport protein AraJ; Provisional; Region: PRK10091
1125630008804	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630008805	putative substrate translocation pore; other site
1125630008806	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1125630008807	active site
1125630008808	metal binding site [ion binding]; metal-binding site
1125630008809	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
1125630008810	Exocyst complex component Sec10; Region: Sec10; pfam07393
1125630008811	formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179
1125630008812	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
1125630008813	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
1125630008814	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
1125630008815	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1125630008816	molybdopterin cofactor binding site; other site
1125630008817	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
1125630008818	molybdopterin cofactor binding site; other site
1125630008819	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1125630008820	aromatic amino acid exporter; Provisional; Region: PRK11689
1125630008821	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823
1125630008822	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1125630008823	NAD(P) binding site [chemical binding]; other site
1125630008824	active site
1125630008825	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
1125630008826	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1125630008827	catalytic loop [active]
1125630008828	iron binding site [ion binding]; other site
1125630008829	Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209
1125630008830	FAD binding pocket [chemical binding]; other site
1125630008831	FAD binding motif [chemical binding]; other site
1125630008832	phosphate binding motif [ion binding]; other site
1125630008833	beta-alpha-beta structure motif; other site
1125630008834	NAD binding pocket [chemical binding]; other site
1125630008835	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
1125630008836	inter-subunit interface; other site
1125630008837	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
1125630008838	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1125630008839	iron-sulfur cluster [ion binding]; other site
1125630008840	[2Fe-2S] cluster binding site [ion binding]; other site
1125630008841	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
1125630008842	putative alpha subunit interface [polypeptide binding]; other site
1125630008843	putative active site [active]
1125630008844	putative substrate binding site [chemical binding]; other site
1125630008845	Fe binding site [ion binding]; other site
1125630008846	catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439
1125630008847	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
1125630008848	active site
1125630008849	Muconolactone delta-isomerase; Region: MIase; cl01992
1125630008850	Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318
1125630008851	muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534
1125630008852	octamer interface [polypeptide binding]; other site
1125630008853	active site
1125630008854	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
1125630008855	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1125630008856	Bacterial transcriptional regulator; Region: IclR; pfam01614
1125630008857	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
1125630008858	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630008859	putative substrate translocation pore; other site
1125630008860	TetR family transcriptional regulator; Provisional; Region: PRK14996
1125630008861	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1125630008862	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
1125630008863	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
1125630008864	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
1125630008865	Respiratory nitrate reductase alpha N-terminal; Region: Nitr_red_alph_N; pfam14710
1125630008866	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
1125630008867	[4Fe-4S] binding site [ion binding]; other site
1125630008868	molybdopterin cofactor binding site [chemical binding]; other site
1125630008869	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
1125630008870	molybdopterin cofactor binding site; other site
1125630008871	potential frameshift: common BLAST hit: gi|152970433|ref|YP_001335542.1| cryptic nitrate reductase 2 subunit beta
1125630008872	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
1125630008873	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
1125630008874	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
1125630008875	Respiratory nitrate reductase beta C-terminal; Region: Nitr_red_bet_C; pfam14711
1125630008876	nitrate reductase 2 subunit delta; Provisional; Region: PRK15054
1125630008877	respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351
1125630008878	N-acetyltransferase; Region: Acetyltransf_2; cl00949
1125630008879	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1125630008880	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630008881	dimer interface [polypeptide binding]; other site
1125630008882	conserved gate region; other site
1125630008883	putative PBP binding loops; other site
1125630008884	ABC-ATPase subunit interface; other site
1125630008885	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630008886	dimer interface [polypeptide binding]; other site
1125630008887	conserved gate region; other site
1125630008888	putative PBP binding loops; other site
1125630008889	ABC-ATPase subunit interface; other site
1125630008890	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1125630008891	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
1125630008892	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1125630008893	Walker A/P-loop; other site
1125630008894	ATP binding site [chemical binding]; other site
1125630008895	Q-loop/lid; other site
1125630008896	ABC transporter signature motif; other site
1125630008897	Walker B; other site
1125630008898	D-loop; other site
1125630008899	H-loop/switch region; other site
1125630008900	transcriptional activator RhaR; Provisional; Region: PRK13501
1125630008901	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1125630008902	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630008903	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
1125630008904	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
1125630008905	putative symporter YagG; Provisional; Region: PRK09669; cl15392
1125630008906	Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471
1125630008907	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1125630008908	maltoporin; Provisional; Region: lamB; PRK09360
1125630008909	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1125630008910	non-specific DNA binding site [nucleotide binding]; other site
1125630008911	salt bridge; other site
1125630008912	sequence-specific DNA binding site [nucleotide binding]; other site
1125630008913	4-oxalocrotonate tautomerase; Provisional; Region: PRK01271
1125630008914	active site 1 [active]
1125630008915	dimer interface [polypeptide binding]; other site
1125630008916	hexamer interface [polypeptide binding]; other site
1125630008917	active site 2 [active]
1125630008918	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
1125630008919	C-terminal domain interface [polypeptide binding]; other site
1125630008920	GSH binding site (G-site) [chemical binding]; other site
1125630008921	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1125630008922	dimer interface [polypeptide binding]; other site
1125630008923	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
1125630008924	N-terminal domain interface [polypeptide binding]; other site
1125630008925	dimer interface [polypeptide binding]; other site
1125630008926	substrate binding pocket (H-site) [chemical binding]; other site
1125630008927	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1125630008928	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1125630008929	substrate binding pocket [chemical binding]; other site
1125630008930	membrane-bound complex binding site; other site
1125630008931	hinge residues; other site
1125630008932	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1125630008933	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1125630008934	Walker A/P-loop; other site
1125630008935	ATP binding site [chemical binding]; other site
1125630008936	Q-loop/lid; other site
1125630008937	ABC transporter signature motif; other site
1125630008938	Walker B; other site
1125630008939	D-loop; other site
1125630008940	H-loop/switch region; other site
1125630008941	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1125630008942	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
1125630008943	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630008944	dimer interface [polypeptide binding]; other site
1125630008945	conserved gate region; other site
1125630008946	putative PBP binding loops; other site
1125630008947	ABC-ATPase subunit interface; other site
1125630008948	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1125630008949	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1125630008950	Coenzyme A binding pocket [chemical binding]; other site
1125630008951	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1125630008952	active site
1125630008953	non-prolyl cis peptide bond; other site
1125630008954	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1125630008955	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1125630008956	substrate binding pocket [chemical binding]; other site
1125630008957	membrane-bound complex binding site; other site
1125630008958	hinge residues; other site
1125630008959	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1125630008960	M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669
1125630008961	metal binding site [ion binding]; metal-binding site
1125630008962	dimer interface [polypeptide binding]; other site
1125630008963	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1125630008964	Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563
1125630008965	AAA domain; Region: AAA_17; cl19128
1125630008966	potential frameshift: common BLAST hit: gi|152970457|ref|YP_001335566.1| LysR family transcriptional regulator
1125630008967	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630008968	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630008969	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1125630008970	dimerization interface [polypeptide binding]; other site
1125630008971	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1125630008972	L-asparagine permease; Provisional; Region: PRK15049
1125630008973	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
1125630008974	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
1125630008975	PQQ-like domain; Region: PQQ_2; pfam13360
1125630008976	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1125630008977	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1125630008978	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1125630008979	N-terminal plug; other site
1125630008980	ligand-binding site [chemical binding]; other site
1125630008981	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
1125630008982	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
1125630008983	active site
1125630008984	hypothetical protein; Provisional; Region: PRK09981
1125630008985	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
1125630008986	active site
1125630008987	tetramer interface [polypeptide binding]; other site
1125630008988	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
1125630008989	Prostaglandin dehydrogenases; Region: PGDH; cd05288
1125630008990	NAD(P) binding site [chemical binding]; other site
1125630008991	substrate binding site [chemical binding]; other site
1125630008992	dimer interface [polypeptide binding]; other site
1125630008993	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1125630008994	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1125630008995	non-specific DNA binding site [nucleotide binding]; other site
1125630008996	salt bridge; other site
1125630008997	sequence-specific DNA binding site [nucleotide binding]; other site
1125630008998	Cupin domain; Region: Cupin_2; cl17218
1125630008999	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1125630009000	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1125630009001	Coenzyme A binding pocket [chemical binding]; other site
1125630009002	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
1125630009003	Protein of unknown function (DUF2526); Region: DUF2526; pfam10735
1125630009004	potential frameshift: common BLAST hit: gi|152970470|ref|YP_001335579.1| dipeptide transport protein
1125630009005	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
1125630009006	peptide binding site [polypeptide binding]; other site
1125630009007	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1125630009008	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1125630009009	Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105
1125630009010	NAD(P) binding site [chemical binding]; other site
1125630009011	catalytic residues [active]
1125630009012	Putative lysophospholipase; Region: Hydrolase_4; cl19140
1125630009013	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1125630009014	Protein of unknown function (DUF2566); Region: DUF2566; pfam10753
1125630009015	potential frameshift: common BLAST hit: gi|152970476|ref|YP_001335585.1| gamma-aminobutyraldehyde dehydrogenase
1125630009016	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1125630009017	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1125630009018	NAD(P) binding site [chemical binding]; other site
1125630009019	catalytic residues [active]
1125630009020	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1125630009021	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630009022	dimer interface [polypeptide binding]; other site
1125630009023	conserved gate region; other site
1125630009024	putative PBP binding loops; other site
1125630009025	ABC-ATPase subunit interface; other site
1125630009026	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630009027	dimer interface [polypeptide binding]; other site
1125630009028	conserved gate region; other site
1125630009029	putative PBP binding loops; other site
1125630009030	ABC-ATPase subunit interface; other site
1125630009031	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1125630009032	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1125630009033	Walker A/P-loop; other site
1125630009034	ATP binding site [chemical binding]; other site
1125630009035	Q-loop/lid; other site
1125630009036	ABC transporter signature motif; other site
1125630009037	Walker B; other site
1125630009038	D-loop; other site
1125630009039	H-loop/switch region; other site
1125630009040	TOBE domain; Region: TOBE_2; pfam08402
1125630009041	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1125630009042	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1125630009043	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1125630009044	DNA-binding site [nucleotide binding]; DNA binding site
1125630009045	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1125630009046	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630009047	homodimer interface [polypeptide binding]; other site
1125630009048	catalytic residue [active]
1125630009049	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1125630009050	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
1125630009051	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1125630009052	Protein of unknown function (DUF2474); Region: DUF2474; pfam10617
1125630009053	pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102
1125630009054	Protein of unknown function (DUF2554); Region: DUF2554; pfam10829
1125630009055	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1125630009056	putative protease; Provisional; Region: PRK15452
1125630009057	Collagenase; Region: DUF3656; pfam12392
1125630009058	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1125630009059	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1125630009060	non-specific DNA binding site [nucleotide binding]; other site
1125630009061	salt bridge; other site
1125630009062	sequence-specific DNA binding site [nucleotide binding]; other site
1125630009063	Cupin domain; Region: Cupin_2; pfam07883
1125630009064	Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135
1125630009065	benzoate transporter; Region: benE; TIGR00843
1125630009066	potential frameshift: common BLAST hit: gi|238894978|ref|YP_002919712.1| AraC family transcriptional regulator
1125630009067	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630009068	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1125630009069	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630009070	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1125630009071	EamA-like transporter family; Region: EamA; pfam00892
1125630009072	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
1125630009073	tellurite resistance protein TehB; Provisional; Region: PRK11207
1125630009074	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1125630009075	S-adenosylmethionine binding site [chemical binding]; other site
1125630009076	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324
1125630009077	gating phenylalanine in ion channel; other site
1125630009078	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1125630009079	putative trimer interface [polypeptide binding]; other site
1125630009080	putative CoA binding site [chemical binding]; other site
1125630009081	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208
1125630009082	putative trimer interface [polypeptide binding]; other site
1125630009083	putative CoA binding site [chemical binding]; other site
1125630009084	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1125630009085	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1125630009086	Coenzyme A binding pocket [chemical binding]; other site
1125630009087	Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131
1125630009088	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
1125630009089	Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278
1125630009090	catalytic Zn binding site [ion binding]; other site
1125630009091	NAD binding site [chemical binding]; other site
1125630009092	structural Zn binding site [ion binding]; other site
1125630009093	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
1125630009094	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
1125630009095	substrate binding pocket [chemical binding]; other site
1125630009096	catalytic triad [active]
1125630009097	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383
1125630009098	Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464
1125630009099	heterodimer interface [polypeptide binding]; other site
1125630009100	multimer interface [polypeptide binding]; other site
1125630009101	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
1125630009102	active site
1125630009103	Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
1125630009104	Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463
1125630009105	heterodimer interface [polypeptide binding]; other site
1125630009106	active site
1125630009107	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
1125630009108	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630009109	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1125630009110	dimerization interface [polypeptide binding]; other site
1125630009111	Cytochrome C biogenesis protein transmembrane region; Region: DsbD_2; pfam13386
1125630009112	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
1125630009113	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
1125630009114	Trp docking motif [polypeptide binding]; other site
1125630009115	putative active site [active]
1125630009116	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
1125630009117	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
1125630009118	substrate binding site [chemical binding]; other site
1125630009119	catalytic Zn binding site [ion binding]; other site
1125630009120	NAD binding site [chemical binding]; other site
1125630009121	structural Zn binding site [ion binding]; other site
1125630009122	dimer interface [polypeptide binding]; other site
1125630009123	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
1125630009124	putative metal binding site [ion binding]; other site
1125630009125	putative homodimer interface [polypeptide binding]; other site
1125630009126	putative homotetramer interface [polypeptide binding]; other site
1125630009127	putative homodimer-homodimer interface [polypeptide binding]; other site
1125630009128	putative allosteric switch controlling residues; other site
1125630009129	cytochrome b561; Provisional; Region: PRK11513
1125630009130	Predicted transcriptional regulators [Transcription]; Region: COG1733
1125630009131	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630009132	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1125630009133	putative substrate translocation pore; other site
1125630009134	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
1125630009135	active site
1125630009136	purine riboside binding site [chemical binding]; other site
1125630009137	putative oxidoreductase; Provisional; Region: PRK11579
1125630009138	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1125630009139	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1125630009140	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
1125630009141	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232
1125630009142	oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391
1125630009143	Protein of unknown function (DUF2569); Region: DUF2569; pfam10754
1125630009144	electron transport complex protein RsxA; Provisional; Region: PRK05151
1125630009145	ferredoxin; Provisional; Region: PRK08764
1125630009146	Putative Fe-S cluster; Region: FeS; cl17515
1125630009147	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
1125630009148	potential frameshift: common BLAST hit: gi|238895009|ref|YP_002919743.1| electron transport complex protein RnfC
1125630009149	Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656
1125630009150	RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375
1125630009151	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
1125630009152	SLBB domain; Region: SLBB; pfam10531
1125630009153	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
1125630009154	Bacterial type III secretion protein (HrpB7); Region: HrpB7; cl09720
1125630009155	electron transport complex protein RnfC; Provisional; Region: PRK05035
1125630009156	electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816
1125630009157	electron transport complex protein RnfG; Validated; Region: PRK01908
1125630009158	electron transport complex RsxE subunit; Provisional; Region: PRK12405
1125630009159	endonuclease III; Provisional; Region: PRK10702
1125630009160	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1125630009161	minor groove reading motif; other site
1125630009162	helix-hairpin-helix signature motif; other site
1125630009163	substrate binding pocket [chemical binding]; other site
1125630009164	active site
1125630009165	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
1125630009166	putative tripeptide transporter permease; Reviewed; Region: tppB; PRK09584
1125630009167	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
1125630009168	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630009169	putative substrate translocation pore; other site
1125630009170	glutathionine S-transferase; Provisional; Region: PRK10542
1125630009171	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
1125630009172	C-terminal domain interface [polypeptide binding]; other site
1125630009173	GSH binding site (G-site) [chemical binding]; other site
1125630009174	dimer interface [polypeptide binding]; other site
1125630009175	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
1125630009176	N-terminal domain interface [polypeptide binding]; other site
1125630009177	dimer interface [polypeptide binding]; other site
1125630009178	substrate binding pocket (H-site) [chemical binding]; other site
1125630009179	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
1125630009180	dimer interface [polypeptide binding]; other site
1125630009181	pyridoxal binding site [chemical binding]; other site
1125630009182	ATP binding site [chemical binding]; other site
1125630009183	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1125630009184	Protein of unknown function (DUF2859); Region: DUF2859; cl12633
1125630009185	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1125630009186	active site
1125630009187	HIGH motif; other site
1125630009188	dimer interface [polypeptide binding]; other site
1125630009189	KMSKS motif; other site
1125630009190	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1125630009191	RNA binding surface [nucleotide binding]; other site
1125630009192	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
1125630009193	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1125630009194	Pyridoxine 5'-phosphate oxidase C-terminal dimerization region; Region: PNPOx_C; pfam10590
1125630009195	lysozyme inhibitor; Provisional; Region: PRK11372
1125630009196	Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702
1125630009197	Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133
1125630009198	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1125630009199	metal binding site [ion binding]; metal-binding site
1125630009200	active site
1125630009201	I-site; other site
1125630009202	potential frameshift: common BLAST hit: gi|288935187|ref|YP_003439246.1| MarR family transcriptional regulator
1125630009203	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
1125630009204	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
1125630009205	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1125630009206	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
1125630009207	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
1125630009208	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1125630009209	HlyD family secretion protein; Region: HlyD_3; pfam13437
1125630009210	Fusaric acid resistance protein family; Region: FUSC; pfam04632
1125630009211	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cl00891
1125630009212	E-class dimer interface [polypeptide binding]; other site
1125630009213	P-class dimer interface [polypeptide binding]; other site
1125630009214	active site
1125630009215	Cu2+ binding site [ion binding]; other site
1125630009216	Zn2+ binding site [ion binding]; other site
1125630009217	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1125630009218	active site
1125630009219	catalytic tetrad [active]
1125630009220	Predicted Fe-S protein [General function prediction only]; Region: COG3313
1125630009221	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1125630009222	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1125630009223	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
1125630009224	FMN binding site [chemical binding]; other site
1125630009225	active site
1125630009226	substrate binding site [chemical binding]; other site
1125630009227	catalytic residue [active]
1125630009228	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
1125630009229	dimer interface [polypeptide binding]; other site
1125630009230	active site
1125630009231	metal binding site [ion binding]; metal-binding site
1125630009232	glutathione binding site [chemical binding]; other site
1125630009233	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
1125630009234	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
1125630009235	dimer interface [polypeptide binding]; other site
1125630009236	catalytic site [active]
1125630009237	putative active site [active]
1125630009238	putative substrate binding site [chemical binding]; other site
1125630009239	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
1125630009240	putative GSH binding site [chemical binding]; other site
1125630009241	catalytic residues [active]
1125630009242	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1125630009243	NlpC/P60 family; Region: NLPC_P60; pfam00877
1125630009244	DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219
1125630009245	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630009246	superoxide dismutase; Provisional; Region: PRK10543
1125630009247	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1125630009248	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1125630009249	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1125630009250	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630009251	putative substrate translocation pore; other site
1125630009252	DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703
1125630009253	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1125630009254	DNA binding site [nucleotide binding]
1125630009255	domain linker motif; other site
1125630009256	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
1125630009257	dimerization interface [polypeptide binding]; other site
1125630009258	ligand binding site [chemical binding]; other site
1125630009259	putative transporter; Provisional; Region: PRK11043
1125630009260	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630009261	putative substrate translocation pore; other site
1125630009262	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
1125630009263	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1125630009264	S-adenosylmethionine binding site [chemical binding]; other site
1125630009265	riboflavin synthase subunit alpha; Provisional; Region: PRK13020
1125630009266	Lumazine binding domain; Region: Lum_binding; pfam00677
1125630009267	Lumazine binding domain; Region: Lum_binding; pfam00677
1125630009268	multidrug efflux protein; Reviewed; Region: PRK01766
1125630009269	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
1125630009270	cation binding site [ion binding]; other site
1125630009271	DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695
1125630009272	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
1125630009273	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1125630009274	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630009275	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1125630009276	dimerization interface [polypeptide binding]; other site
1125630009277	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1125630009278	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
1125630009279	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1125630009280	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
1125630009281	active site clefts [active]
1125630009282	zinc binding site [ion binding]; other site
1125630009283	dimer interface [polypeptide binding]; other site
1125630009284	LysE type translocator; Region: LysE; cl00565
1125630009285	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1125630009286	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
1125630009287	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1125630009288	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241
1125630009289	putative metal binding site [ion binding]; other site
1125630009290	Chloramphenicol acetyltransferase; Region: CAT; cl02008
1125630009291	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1125630009292	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
1125630009293	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1125630009294	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630009295	dimer interface [polypeptide binding]; other site
1125630009296	conserved gate region; other site
1125630009297	putative PBP binding loops; other site
1125630009298	ABC-ATPase subunit interface; other site
1125630009299	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1125630009300	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1125630009301	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630009302	dimer interface [polypeptide binding]; other site
1125630009303	conserved gate region; other site
1125630009304	putative PBP binding loops; other site
1125630009305	ABC-ATPase subunit interface; other site
1125630009306	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1125630009307	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1125630009308	Walker A/P-loop; other site
1125630009309	ATP binding site [chemical binding]; other site
1125630009310	Q-loop/lid; other site
1125630009311	ABC transporter signature motif; other site
1125630009312	Walker B; other site
1125630009313	D-loop; other site
1125630009314	H-loop/switch region; other site
1125630009315	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1125630009316	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
1125630009317	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1125630009318	Walker A/P-loop; other site
1125630009319	ATP binding site [chemical binding]; other site
1125630009320	Q-loop/lid; other site
1125630009321	ABC transporter signature motif; other site
1125630009322	Walker B; other site
1125630009323	D-loop; other site
1125630009324	H-loop/switch region; other site
1125630009325	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1125630009326	Domain of unknown function (DUF3315); Region: DUF3315; cl02275
1125630009327	DinB family; Region: DinB; cl17821
1125630009328	potential frameshift: common BLAST hit: gi|152970575|ref|YP_001335684.1| putative transport protein
1125630009329	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630009330	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630009331	putative substrate translocation pore; other site
1125630009332	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1125630009333	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630009334	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630009335	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476
1125630009336	putative effector binding pocket; other site
1125630009337	putative dimerization interface [polypeptide binding]; other site
1125630009338	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268
1125630009339	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1125630009340	putative NAD(P) binding site [chemical binding]; other site
1125630009341	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630009342	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1125630009343	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
1125630009344	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
1125630009345	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
1125630009346	amidohydrolase; Provisional; Region: PRK12393
1125630009347	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
1125630009348	active site
1125630009349	putative substrate binding pocket [chemical binding]; other site
1125630009350	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1125630009351	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
1125630009352	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630009353	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630009354	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1125630009355	dimerization interface [polypeptide binding]; other site
1125630009356	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1125630009357	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
1125630009358	FMN-binding pocket [chemical binding]; other site
1125630009359	flavin binding motif; other site
1125630009360	phosphate binding motif [ion binding]; other site
1125630009361	beta-alpha-beta structure motif; other site
1125630009362	NAD binding pocket [chemical binding]; other site
1125630009363	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1125630009364	catalytic loop [active]
1125630009365	iron binding site [ion binding]; other site
1125630009366	cytosine deaminase-like protein; Validated; Region: PRK07583
1125630009367	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1125630009368	active site
1125630009369	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1125630009370	homotrimer interaction site [polypeptide binding]; other site
1125630009371	putative active site [active]
1125630009372	Creatinine amidohydrolase; Region: Creatininase; pfam02633
1125630009373	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1125630009374	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
1125630009375	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1125630009376	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1125630009377	Walker A/P-loop; other site
1125630009378	ATP binding site [chemical binding]; other site
1125630009379	Q-loop/lid; other site
1125630009380	ABC transporter signature motif; other site
1125630009381	Walker B; other site
1125630009382	D-loop; other site
1125630009383	H-loop/switch region; other site
1125630009384	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1125630009385	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630009386	dimer interface [polypeptide binding]; other site
1125630009387	conserved gate region; other site
1125630009388	putative PBP binding loops; other site
1125630009389	ABC-ATPase subunit interface; other site
1125630009390	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1125630009391	FAD binding domain; Region: FAD_binding_4; pfam01565
1125630009392	Chromate transporter; Region: Chromate_transp; pfam02417
1125630009393	Protein of unknown function (DUF535); Region: DUF535; cl01128
1125630009394	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630009395	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630009396	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
1125630009397	putative dimerization interface [polypeptide binding]; other site
1125630009398	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
1125630009399	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
1125630009400	potential frameshift: common BLAST hit: gi|238895095|ref|YP_002919830.1| beta-ketothiolase
1125630009401	Thiolase, N-terminal domain; Region: Thiolase_N; pfam00108
1125630009402	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1125630009403	dimer interface [polypeptide binding]; other site
1125630009404	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
1125630009405	active site
1125630009406	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1125630009407	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
1125630009408	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1125630009409	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
1125630009410	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
1125630009411	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1125630009412	NAD(P) binding site [chemical binding]; other site
1125630009413	active site
1125630009414	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630009415	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630009416	The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451
1125630009417	putative dimerization interface [polypeptide binding]; other site
1125630009418	putative substrate binding pocket [chemical binding]; other site
1125630009419	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
1125630009420	acetolactate synthase, catabolic; Region: acolac_catab; TIGR02418
1125630009421	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1125630009422	PYR/PP interface [polypeptide binding]; other site
1125630009423	dimer interface [polypeptide binding]; other site
1125630009424	TPP binding site [chemical binding]; other site
1125630009425	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1125630009426	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
1125630009427	TPP-binding site [chemical binding]; other site
1125630009428	dimer interface [polypeptide binding]; other site
1125630009429	acetoin reductase; Validated; Region: PRK08643
1125630009430	meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366
1125630009431	NAD binding site [chemical binding]; other site
1125630009432	homotetramer interface [polypeptide binding]; other site
1125630009433	homodimer interface [polypeptide binding]; other site
1125630009434	active site
1125630009435	substrate binding site [chemical binding]; other site
1125630009436	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1125630009437	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1125630009438	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
1125630009439	MMPL family; Region: MMPL; cl14618
1125630009440	ABC transporter transmembrane region; Region: ABC_membrane_3; pfam13748
1125630009441	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1125630009442	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1125630009443	active site
1125630009444	phosphorylation site [posttranslational modification]
1125630009445	intermolecular recognition site; other site
1125630009446	dimerization interface [polypeptide binding]; other site
1125630009447	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1125630009448	DNA binding site [nucleotide binding]
1125630009449	FtsX-like permease family; Region: FtsX; pfam02687
1125630009450	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1125630009451	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1125630009452	dimerization interface [polypeptide binding]; other site
1125630009453	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1125630009454	dimer interface [polypeptide binding]; other site
1125630009455	phosphorylation site [posttranslational modification]
1125630009456	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1125630009457	ATP binding site [chemical binding]; other site
1125630009458	Mg2+ binding site [ion binding]; other site
1125630009459	G-X-G motif; other site
1125630009460	TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305
1125630009461	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
1125630009462	putative dimer interface [polypeptide binding]; other site
1125630009463	catalytic triad [active]
1125630009464	potential frameshift: common BLAST hit: gi|238895109|ref|YP_002919844.1| putative subunit of heme lyase
1125630009465	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
1125630009466	Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088
1125630009467	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
1125630009468	catalytic residues [active]
1125630009469	central insert; other site
1125630009470	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
1125630009471	CcmE; Region: CcmE; cl00994
1125630009472	Heme exporter protein D (CcmD); Region: CcmD; cl11475
1125630009473	heme exporter protein CcmC; Region: ccmC; TIGR01191
1125630009474	heme exporter protein CcmB; Region: ccmB; TIGR01190
1125630009475	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
1125630009476	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1125630009477	Walker A/P-loop; other site
1125630009478	ATP binding site [chemical binding]; other site
1125630009479	Q-loop/lid; other site
1125630009480	ABC transporter signature motif; other site
1125630009481	Walker B; other site
1125630009482	D-loop; other site
1125630009483	H-loop/switch region; other site
1125630009484	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1125630009485	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1125630009486	Cytochrome c; Region: Cytochrom_C; cl11414
1125630009487	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1125630009488	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1125630009489	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
1125630009490	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
1125630009491	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1125630009492	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1125630009493	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
1125630009494	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
1125630009495	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1125630009496	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1125630009497	Walker A/P-loop; other site
1125630009498	ATP binding site [chemical binding]; other site
1125630009499	Q-loop/lid; other site
1125630009500	ABC transporter signature motif; other site
1125630009501	Walker B; other site
1125630009502	D-loop; other site
1125630009503	H-loop/switch region; other site
1125630009504	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1125630009505	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630009506	dimer interface [polypeptide binding]; other site
1125630009507	conserved gate region; other site
1125630009508	putative PBP binding loops; other site
1125630009509	ABC-ATPase subunit interface; other site
1125630009510	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630009511	dimer interface [polypeptide binding]; other site
1125630009512	conserved gate region; other site
1125630009513	putative PBP binding loops; other site
1125630009514	ABC-ATPase subunit interface; other site
1125630009515	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1125630009516	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1125630009517	putative dehydrogenase; Provisional; Region: PRK10098
1125630009518	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
1125630009519	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
1125630009520	[4Fe-4S] binding site [ion binding]; other site
1125630009521	molybdopterin cofactor binding site; other site
1125630009522	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790
1125630009523	molybdopterin cofactor binding site; other site
1125630009524	potential frameshift: common BLAST hit: gi|152970640|ref|YP_001335749.1| putative metal-dependent amidase/aminoacylase/carboxypeptidase
1125630009525	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1125630009526	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1125630009527	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
1125630009528	metal binding site [ion binding]; metal-binding site
1125630009529	putative dimer interface [polypeptide binding]; other site
1125630009530	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630009531	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1125630009532	putative substrate translocation pore; other site
1125630009533	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
1125630009534	multidrug efflux system protein MdtM; Provisional; Region: PRK15403
1125630009535	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630009536	putative substrate translocation pore; other site
1125630009537	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
1125630009538	Protein of unknown function (DUF1062); Region: DUF1062; pfam06353
1125630009539	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1125630009540	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1125630009541	Walker A/P-loop; other site
1125630009542	ATP binding site [chemical binding]; other site
1125630009543	Q-loop/lid; other site
1125630009544	ABC transporter signature motif; other site
1125630009545	Walker B; other site
1125630009546	D-loop; other site
1125630009547	H-loop/switch region; other site
1125630009548	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
1125630009549	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630009550	dimer interface [polypeptide binding]; other site
1125630009551	conserved gate region; other site
1125630009552	putative PBP binding loops; other site
1125630009553	ABC-ATPase subunit interface; other site
1125630009554	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1125630009555	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1125630009556	substrate binding pocket [chemical binding]; other site
1125630009557	membrane-bound complex binding site; other site
1125630009558	hinge residues; other site
1125630009559	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1125630009560	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1125630009561	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cd04795
1125630009562	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1125630009563	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1125630009564	intersubunit interface [polypeptide binding]; other site
1125630009565	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1125630009566	ABC-ATPase subunit  interface; other site
1125630009567	dimer interface [polypeptide binding]; other site
1125630009568	putative PBP binding regions; other site
1125630009569	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1125630009570	ABC-ATPase subunit  interface; other site
1125630009571	dimer interface [polypeptide binding]; other site
1125630009572	putative PBP binding regions; other site
1125630009573	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1125630009574	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1125630009575	Walker A/P-loop; other site
1125630009576	ATP binding site [chemical binding]; other site
1125630009577	Q-loop/lid; other site
1125630009578	ABC transporter signature motif; other site
1125630009579	Walker B; other site
1125630009580	D-loop; other site
1125630009581	H-loop/switch region; other site
1125630009582	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1125630009583	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1125630009584	N-terminal plug; other site
1125630009585	ligand-binding site [chemical binding]; other site
1125630009586	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1125630009587	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1125630009588	Walker A/P-loop; other site
1125630009589	ATP binding site [chemical binding]; other site
1125630009590	Q-loop/lid; other site
1125630009591	ABC transporter signature motif; other site
1125630009592	Walker B; other site
1125630009593	D-loop; other site
1125630009594	H-loop/switch region; other site
1125630009595	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1125630009596	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630009597	dimer interface [polypeptide binding]; other site
1125630009598	conserved gate region; other site
1125630009599	putative PBP binding loops; other site
1125630009600	ABC-ATPase subunit interface; other site
1125630009601	NMT1-like family; Region: NMT1_2; cl17432
1125630009602	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1125630009603	NMT1-like family; Region: NMT1_2; cl17432
1125630009604	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1125630009605	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1125630009606	membrane-bound complex binding site; other site
1125630009607	hinge residues; other site
1125630009608	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1125630009609	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; cl09932
1125630009610	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1125630009611	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
1125630009612	dimer interface [polypeptide binding]; other site
1125630009613	active site
1125630009614	non-prolyl cis peptide bond; other site
1125630009615	insertion regions; other site
1125630009616	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630009617	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630009618	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1125630009619	dimerization interface [polypeptide binding]; other site
1125630009620	Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553
1125630009621	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1125630009622	active site residue [active]
1125630009623	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1125630009624	active site residue [active]
1125630009625	Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534
1125630009626	active site residue [active]
1125630009627	Member of the Rhodanese Homology Domain superfamily, repeat 4. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 4th repeat which, in general, contains the putative...; Region: 4RHOD_Repeat_4; cd01535
1125630009628	active site residue [active]
1125630009629	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
1125630009630	putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551
1125630009631	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630009632	putative substrate translocation pore; other site
1125630009633	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
1125630009634	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
1125630009635	active site
1125630009636	catalytic residues [active]
1125630009637	metal binding site [ion binding]; metal-binding site
1125630009638	DmpG-like communication domain; Region: DmpG_comm; pfam07836
1125630009639	acetaldehyde dehydrogenase; Validated; Region: PRK08300
1125630009640	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118
1125630009641	Prokaryotic acetaldehyde dehydrogenase, dimerization; Region: AcetDehyd-dimer; pfam09290
1125630009642	2-keto-4-pentenoate hydratase; Provisional; Region: mhpD; PRK11342
1125630009643	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
1125630009644	Putative lysophospholipase; Region: Hydrolase_4; cl19140
1125630009645	potential frameshift: common BLAST hit: gi|152970670|ref|YP_001335779.1| 3-(2,3-dihydroxyphenyl)propionate dioxygenase
1125630009646	Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599
1125630009647	active site
1125630009648	metal binding site [ion binding]; metal-binding site
1125630009649	Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599
1125630009650	3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183
1125630009651	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1125630009652	DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834
1125630009653	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1125630009654	Bacterial transcriptional regulator; Region: IclR; pfam01614
1125630009655	Periplasmic binding protein TroA_e.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142
1125630009656	putative ligand binding residues [chemical binding]; other site
1125630009657	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1125630009658	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1125630009659	ABC-ATPase subunit  interface; other site
1125630009660	dimer interface [polypeptide binding]; other site
1125630009661	putative PBP binding regions; other site
1125630009662	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1125630009663	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1125630009664	Walker A/P-loop; other site
1125630009665	ATP binding site [chemical binding]; other site
1125630009666	Q-loop/lid; other site
1125630009667	ABC transporter signature motif; other site
1125630009668	Walker B; other site
1125630009669	D-loop; other site
1125630009670	H-loop/switch region; other site
1125630009671	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1125630009672	shikimate 5-dehydrogenase; Provisional; Region: PRK12548
1125630009673	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1125630009674	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1125630009675	shikimate binding site; other site
1125630009676	NAD(P) binding site [chemical binding]; other site
1125630009677	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630009678	D-galactonate transporter; Region: 2A0114; TIGR00893
1125630009679	putative substrate translocation pore; other site
1125630009680	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1125630009681	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1125630009682	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
1125630009683	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
1125630009684	dimer interface [polypeptide binding]; other site
1125630009685	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
1125630009686	active site
1125630009687	Fe binding site [ion binding]; other site
1125630009688	HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008
1125630009689	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1125630009690	Protein of unknown function (DUF2767); Region: DUF2767; pfam10965
1125630009691	pyruvate kinase; Provisional; Region: PRK09206
1125630009692	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288
1125630009693	domain interfaces; other site
1125630009694	active site
1125630009695	murein lipoprotein; Provisional; Region: PRK15396
1125630009696	L,D-transpeptidase; Provisional; Region: PRK10260
1125630009697	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1125630009698	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1125630009699	cysteine desufuration protein SufE; Provisional; Region: PRK09296
1125630009700	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1125630009701	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1125630009702	catalytic residue [active]
1125630009703	cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948
1125630009704	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
1125630009705	cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580
1125630009706	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
1125630009707	Walker A/P-loop; other site
1125630009708	ATP binding site [chemical binding]; other site
1125630009709	Q-loop/lid; other site
1125630009710	ABC transporter signature motif; other site
1125630009711	Walker B; other site
1125630009712	D-loop; other site
1125630009713	H-loop/switch region; other site
1125630009714	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
1125630009715	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
1125630009716	iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504
1125630009717	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
1125630009718	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1125630009719	DoxX; Region: DoxX; pfam07681
1125630009720	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1125630009721	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1125630009722	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
1125630009723	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
1125630009724	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
1125630009725	active site
1125630009726	substrate binding site [chemical binding]; other site
1125630009727	FMN binding site [chemical binding]; other site
1125630009728	putative catalytic residues [active]
1125630009729	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1125630009730	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1125630009731	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1125630009732	HlyD family secretion protein; Region: HlyD_3; pfam13437
1125630009733	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1125630009734	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1125630009735	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1125630009736	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1125630009737	NAD(P) binding site [chemical binding]; other site
1125630009738	active site
1125630009739	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630009740	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630009741	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1125630009742	dimerization interface [polypeptide binding]; other site
1125630009743	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1125630009744	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1125630009745	intersubunit interface [polypeptide binding]; other site
1125630009746	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1125630009747	ABC-ATPase subunit  interface; other site
1125630009748	dimer interface [polypeptide binding]; other site
1125630009749	putative PBP binding regions; other site
1125630009750	potential frameshift: common BLAST hit: gi|348589205|ref|YP_004870008.1| iron ABC transport system ATP-binding protein
1125630009751	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1125630009752	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1125630009753	Walker A/P-loop; other site
1125630009754	ATP binding site [chemical binding]; other site
1125630009755	Q-loop/lid; other site
1125630009756	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1125630009757	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1125630009758	Walker B; other site
1125630009759	D-loop; other site
1125630009760	H-loop/switch region; other site
1125630009761	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630009762	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1125630009763	putative substrate translocation pore; other site
1125630009764	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1125630009765	substrate binding site [chemical binding]; other site
1125630009766	THF binding site; other site
1125630009767	zinc-binding site [ion binding]; other site
1125630009768	Domain of unknown function (DUF1852); Region: DUF1852; pfam08908
1125630009769	hypothetical protein; Provisional; Region: PRK10457
1125630009770	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1125630009771	CoenzymeA binding site [chemical binding]; other site
1125630009772	subunit interaction site [polypeptide binding]; other site
1125630009773	PHB binding site; other site
1125630009774	potential frameshift: common BLAST hit: gi|238895212|ref|YP_002919947.1| putative oxidase
1125630009775	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1125630009776	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
1125630009777	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1125630009778	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
1125630009779	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1125630009780	FAD binding domain; Region: FAD_binding_4; pfam01565
1125630009781	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
1125630009782	putative inner membrane protein; Provisional; Region: PRK10983
1125630009783	phosphoenolpyruvate synthase; Validated; Region: PRK06464
1125630009784	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
1125630009785	PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1125630009786	PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1125630009787	PEP synthetase regulatory protein; Provisional; Region: PRK05339
1125630009788	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756
1125630009789	hypothetical protein; Provisional; Region: PRK10183
1125630009790	hypothetical protein; Validated; Region: PRK00029
1125630009791	Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405
1125630009792	NlpC/P60 family; Region: NLPC_P60; pfam00877
1125630009793	vitamin B12-transporter ATPase; Provisional; Region: PRK03695
1125630009794	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1125630009795	Walker A/P-loop; other site
1125630009796	ATP binding site [chemical binding]; other site
1125630009797	Q-loop/lid; other site
1125630009798	ABC transporter signature motif; other site
1125630009799	Walker B; other site
1125630009800	D-loop; other site
1125630009801	H-loop/switch region; other site
1125630009802	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1125630009803	catalytic residues [active]
1125630009804	dimer interface [polypeptide binding]; other site
1125630009805	NLPA lipoprotein; Region: Lipoprotein_9; cl19159
1125630009806	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1125630009807	ABC-ATPase subunit  interface; other site
1125630009808	dimer interface [polypeptide binding]; other site
1125630009809	putative PBP binding regions; other site
1125630009810	Predicted membrane protein [Function unknown]; Region: COG1288; cl17886
1125630009811	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630009812	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630009813	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1125630009814	dimerization interface [polypeptide binding]; other site
1125630009815	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
1125630009816	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1125630009817	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
1125630009818	homotrimer interaction site [polypeptide binding]; other site
1125630009819	putative active site [active]
1125630009820	Alpha subunit of integration host factor (IHFA); Region: IHF_A; cd13835
1125630009821	DNA binding site [nucleotide binding]
1125630009822	dimer interface [polypeptide binding]; other site
1125630009823	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1125630009824	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1125630009825	putative tRNA-binding site [nucleotide binding]; other site
1125630009826	B3/4 domain; Region: B3_4; pfam03483
1125630009827	tRNA synthetase B5 domain; Region: B5; smart00874
1125630009828	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1125630009829	dimer interface [polypeptide binding]; other site
1125630009830	motif 1; other site
1125630009831	motif 3; other site
1125630009832	motif 2; other site
1125630009833	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
1125630009834	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1125630009835	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1125630009836	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1125630009837	dimer interface [polypeptide binding]; other site
1125630009838	motif 1; other site
1125630009839	active site
1125630009840	motif 2; other site
1125630009841	motif 3; other site
1125630009842	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
1125630009843	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
1125630009844	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1125630009845	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
1125630009846	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
1125630009847	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
1125630009848	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1125630009849	active site
1125630009850	dimer interface [polypeptide binding]; other site
1125630009851	motif 1; other site
1125630009852	motif 2; other site
1125630009853	motif 3; other site
1125630009854	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1125630009855	anticodon binding site; other site
1125630009856	Protein of unknown function (DUF1471); Region: DUF1471; cl11507
1125630009857	Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137
1125630009858	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1125630009859	putative substrate binding site [chemical binding]; other site
1125630009860	putative ATP binding site [chemical binding]; other site
1125630009861	Protein of unknown function (DUF2622); Region: DUF2622; pfam11080
1125630009862	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3001
1125630009863	Phosphotransferase enzyme family; Region: APH; pfam01636
1125630009864	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1125630009865	active site
1125630009866	substrate binding site [chemical binding]; other site
1125630009867	ATP binding site [chemical binding]; other site
1125630009868	transport protein TonB; Provisional; Region: PRK10819
1125630009869	Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544
1125630009870	YciI-like protein; Reviewed; Region: PRK11370
1125630009871	Uncharacterized conserved protein [Function unknown]; Region: COG2353
1125630009872	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
1125630009873	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
1125630009874	Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152
1125630009875	putative active site [active]
1125630009876	catalytic site [active]
1125630009877	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158
1125630009878	putative active site [active]
1125630009879	catalytic site [active]
1125630009880	dsDNA-mimic protein; Reviewed; Region: PRK05094
1125630009881	Ion transport protein; Region: Ion_trans; pfam00520
1125630009882	Ion channel; Region: Ion_trans_2; pfam07885
1125630009883	Double zinc ribbon; Region: DZR; pfam12773
1125630009884	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
1125630009885	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
1125630009886	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1125630009887	Walker A/P-loop; other site
1125630009888	ATP binding site [chemical binding]; other site
1125630009889	Q-loop/lid; other site
1125630009890	ABC transporter signature motif; other site
1125630009891	Walker B; other site
1125630009892	D-loop; other site
1125630009893	H-loop/switch region; other site
1125630009894	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1125630009895	oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473
1125630009896	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1125630009897	Walker A/P-loop; other site
1125630009898	ATP binding site [chemical binding]; other site
1125630009899	Q-loop/lid; other site
1125630009900	ABC transporter signature motif; other site
1125630009901	Walker B; other site
1125630009902	D-loop; other site
1125630009903	H-loop/switch region; other site
1125630009904	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1125630009905	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
1125630009906	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1125630009907	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630009908	dimer interface [polypeptide binding]; other site
1125630009909	conserved gate region; other site
1125630009910	putative PBP binding loops; other site
1125630009911	ABC-ATPase subunit interface; other site
1125630009912	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
1125630009913	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630009914	dimer interface [polypeptide binding]; other site
1125630009915	conserved gate region; other site
1125630009916	putative PBP binding loops; other site
1125630009917	ABC-ATPase subunit interface; other site
1125630009918	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1125630009919	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1125630009920	peptide binding site [polypeptide binding]; other site
1125630009921	hypothetical protein; Provisional; Region: PRK11111
1125630009922	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
1125630009923	Coenzyme A acylating aldehyde dehydrogenase (ACDH), Ethanolamine utilization protein EutE, and related proteins; Region: ALDH_F20_ACDH_EutE-like; cd07081
1125630009924	putative catalytic cysteine [active]
1125630009925	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
1125630009926	putative active site [active]
1125630009927	metal binding site [ion binding]; metal-binding site
1125630009928	thymidine kinase; Provisional; Region: PRK04296
1125630009929	global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947
1125630009930	DNA-binding protein H-NS [General function prediction only]; Region: Hns; COG2916
1125630009931	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1125630009932	active site
1125630009933	tetramer interface; other site
1125630009934	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1125630009935	active site
1125630009936	response regulator of RpoS; Provisional; Region: PRK10693
1125630009937	phosphorylation site [posttranslational modification]
1125630009938	intermolecular recognition site; other site
1125630009939	dimerization interface [polypeptide binding]; other site
1125630009940	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
1125630009941	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
1125630009942	active site
1125630009943	nucleophile elbow; other site
1125630009944	SEC-C motif; Region: SEC-C; cl19389
1125630009945	SEC-C motif; Region: SEC-C; cl19389
1125630009946	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
1125630009947	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
1125630009948	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
1125630009949	putative active site [active]
1125630009950	putative substrate binding site [chemical binding]; other site
1125630009951	putative cosubstrate binding site; other site
1125630009952	catalytic site [active]
1125630009953	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1125630009954	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
1125630009955	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1125630009956	EamA-like transporter family; Region: EamA; pfam00892
1125630009957	EamA-like transporter family; Region: EamA; pfam00892
1125630009958	respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351
1125630009959	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
1125630009960	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
1125630009961	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
1125630009962	Respiratory nitrate reductase beta C-terminal; Region: Nitr_red_bet_C; pfam14711
1125630009963	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
1125630009964	Respiratory nitrate reductase alpha N-terminal; Region: Nitr_red_alph_N; pfam14710
1125630009965	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
1125630009966	[4Fe-4S] binding site [ion binding]; other site
1125630009967	molybdopterin cofactor binding site [chemical binding]; other site
1125630009968	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
1125630009969	molybdopterin cofactor binding site; other site
1125630009970	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
1125630009971	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630009972	putative substrate translocation pore; other site
1125630009973	nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600
1125630009974	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
1125630009975	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1125630009976	dimerization interface [polypeptide binding]; other site
1125630009977	Histidine kinase; Region: HisKA_3; pfam07730
1125630009978	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1125630009979	ATP binding site [chemical binding]; other site
1125630009980	Mg2+ binding site [ion binding]; other site
1125630009981	G-X-G motif; other site
1125630009982	transcriptional regulator NarL; Provisional; Region: PRK10651
1125630009983	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1125630009984	active site
1125630009985	phosphorylation site [posttranslational modification]
1125630009986	intermolecular recognition site; other site
1125630009987	dimerization interface [polypeptide binding]; other site
1125630009988	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1125630009989	DNA binding residues [nucleotide binding]
1125630009990	dimerization interface [polypeptide binding]; other site
1125630009991	putative invasin; Provisional; Region: PRK10177
1125630009992	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
1125630009993	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
1125630009994	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
1125630009995	[4Fe-4S] binding site [ion binding]; other site
1125630009996	molybdopterin cofactor binding site; other site
1125630009997	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
1125630009998	molybdopterin cofactor binding site; other site
1125630009999	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1125630010000	potential frameshift: common BLAST hit: gi|238895280|ref|YP_002920015.1| putative nitrite reductase [NAD(P)H] large subunit
1125630010001	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1125630010002	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1125630010003	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
1125630010004	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
1125630010005	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1125630010006	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1125630010007	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1125630010008	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1125630010009	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1125630010010	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1125630010011	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1125630010012	Walker A/P-loop; other site
1125630010013	ATP binding site [chemical binding]; other site
1125630010014	Q-loop/lid; other site
1125630010015	ABC transporter signature motif; other site
1125630010016	Walker B; other site
1125630010017	D-loop; other site
1125630010018	H-loop/switch region; other site
1125630010019	potential frameshift: common BLAST hit: gi|238895282|ref|YP_002920017.1| nitrate transporter component
1125630010020	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630010021	ABC-ATPase subunit interface; other site
1125630010022	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1125630010023	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1125630010024	NMT1-like family; Region: NMT1_2; pfam13379
1125630010025	Nitrate and nitrite sensing; Region: NIT; pfam08376
1125630010026	ANTAR domain; Region: ANTAR; pfam03861
1125630010027	Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553
1125630010028	Domain of unknown function (DUF1883); Region: DUF1883; pfam08980
1125630010029	Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703
1125630010030	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
1125630010031	putative active site pocket [active]
1125630010032	dimerization interface [polypeptide binding]; other site
1125630010033	putative catalytic residue [active]
1125630010034	cation transport regulator; Reviewed; Region: chaB; PRK09582
1125630010035	calcium/sodium:proton antiporter; Provisional; Region: PRK10599
1125630010036	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1125630010037	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877
1125630010038	hypothetical protein; Provisional; Region: PRK10941
1125630010039	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
1125630010040	hypothetical protein; Provisional; Region: PRK10278
1125630010041	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1125630010042	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1125630010043	S-adenosylmethionine binding site [chemical binding]; other site
1125630010044	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1125630010045	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1125630010046	RF-1 domain; Region: RF-1; pfam00472
1125630010047	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
1125630010048	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
1125630010049	tRNA; other site
1125630010050	putative tRNA binding site [nucleotide binding]; other site
1125630010051	putative NADP binding site [chemical binding]; other site
1125630010052	Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745
1125630010053	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
1125630010054	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
1125630010055	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1125630010056	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1125630010057	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
1125630010058	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1125630010059	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1125630010060	active site
1125630010061	putative transporter; Provisional; Region: PRK11660
1125630010062	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1125630010063	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1125630010064	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1125630010065	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1125630010066	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1125630010067	DNA binding residues [nucleotide binding]
1125630010068	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
1125630010069	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
1125630010070	hypothetical protein; Provisional; Region: PRK10692
1125630010071	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1125630010072	putative active site [active]
1125630010073	catalytic residue [active]
1125630010074	GTP-binding protein YchF; Reviewed; Region: PRK09601
1125630010075	YchF GTPase; Region: YchF; cd01900
1125630010076	G1 box; other site
1125630010077	GTP/Mg2+ binding site [chemical binding]; other site
1125630010078	Switch I region; other site
1125630010079	G2 box; other site
1125630010080	Switch II region; other site
1125630010081	G3 box; other site
1125630010082	G4 box; other site
1125630010083	G5 box; other site
1125630010084	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1125630010085	Domain of unknown function (DUF1869); Region: DUF1869; pfam08956
1125630010086	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
1125630010087	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1125630010088	putative ligand binding site [chemical binding]; other site
1125630010089	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3515
1125630010090	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
1125630010091	ImpA domain protein; Region: DUF3702; pfam12486
1125630010092	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
1125630010093	Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790
1125630010094	Protein of unknown function (DUF1305); Region: DUF1305; pfam06996
1125630010095	Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947
1125630010096	Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and    vesicular transport]; Region: IcmF; COG3523
1125630010097	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
1125630010098	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
1125630010099	PAAR motif; Region: PAAR_motif; pfam05488
1125630010100	potential frameshift: common BLAST hit: gi|238895322|ref|YP_002920057.1| sulfatase modifying factor 1 precursor-like protein
1125630010101	Uncharacterized conserved protein [Function unknown]; Region: COG1262
1125630010102	Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; cl19582
1125630010103	Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; cl19582
1125630010104	Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; cl19582
1125630010105	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
1125630010106	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1125630010107	Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; cl19582
1125630010108	Uncharacterized conserved protein [Function unknown]; Region: COG1262
1125630010109	Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; cl19582
1125630010110	Uncharacterized conserved protein [Function unknown]; Region: COG1262
1125630010111	Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; cl19582
1125630010112	S-type Pyocin; Region: Pyocin_S; pfam06958
1125630010113	Rhs element Vgr protein; Region: vgr_GE; TIGR01646
1125630010114	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
1125630010115	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
1125630010116	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
1125630010117	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
1125630010118	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1125630010119	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1125630010120	ligand binding site [chemical binding]; other site
1125630010121	type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349
1125630010122	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
1125630010123	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
1125630010124	putative active site pocket [active]
1125630010125	dimerization interface [polypeptide binding]; other site
1125630010126	putative catalytic residue [active]
1125630010127	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122
1125630010128	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1125630010129	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1125630010130	active site
1125630010131	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1125630010132	DNA-binding site [nucleotide binding]; DNA binding site
1125630010133	RNA-binding motif; other site
1125630010134	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630010135	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630010136	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
1125630010137	putative dimerization interface [polypeptide binding]; other site
1125630010138	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1125630010139	potential frameshift: common BLAST hit: gi|152970829|ref|YP_001335938.1| major facilitator superfamily permease
1125630010140	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630010141	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630010142	putative substrate translocation pore; other site
1125630010143	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
1125630010144	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630010145	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1125630010146	dimerization interface [polypeptide binding]; other site
1125630010147	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1125630010148	Coenzyme A binding pocket [chemical binding]; other site
1125630010149	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
1125630010150	active site
1125630010151	substrate-binding site [chemical binding]; other site
1125630010152	metal-binding site [ion binding]
1125630010153	ATP binding site [chemical binding]; other site
1125630010154	cell density-dependent motility repressor; Provisional; Region: PRK10082
1125630010155	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630010156	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1125630010157	dimerization interface [polypeptide binding]; other site
1125630010158	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1125630010159	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1125630010160	Walker A/P-loop; other site
1125630010161	ATP binding site [chemical binding]; other site
1125630010162	Q-loop/lid; other site
1125630010163	ABC transporter signature motif; other site
1125630010164	Walker B; other site
1125630010165	D-loop; other site
1125630010166	H-loop/switch region; other site
1125630010167	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
1125630010168	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1125630010169	Walker A/P-loop; other site
1125630010170	ATP binding site [chemical binding]; other site
1125630010171	Q-loop/lid; other site
1125630010172	ABC transporter signature motif; other site
1125630010173	Walker B; other site
1125630010174	D-loop; other site
1125630010175	H-loop/switch region; other site
1125630010176	potential frameshift: common BLAST hit: gi|238895343|ref|YP_002920078.1| ABC-type high-affinity branched-chain amino acid transport system
1125630010177	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1125630010178	TM-ABC transporter signature motif; other site
1125630010179	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
1125630010180	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1125630010181	TM-ABC transporter signature motif; other site
1125630010182	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
1125630010183	dimerization interface [polypeptide binding]; other site
1125630010184	Receptor family ligand binding region; Region: ANF_receptor; pfam01094
1125630010185	ligand binding site [chemical binding]; other site
1125630010186	potential frameshift: common BLAST hit: gi|288934785|ref|YP_003438844.1| formate acetyltransferase
1125630010187	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
1125630010188	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
1125630010189	propionate/acetate kinase; Provisional; Region: PRK12379
1125630010190	threonine/serine transporter TdcC; Provisional; Region: PRK13629
1125630010191	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
1125630010192	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1125630010193	tetramer interface [polypeptide binding]; other site
1125630010194	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630010195	catalytic residue [active]
1125630010196	DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341
1125630010197	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630010198	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1125630010199	dimerization interface [polypeptide binding]; other site
1125630010200	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096
1125630010201	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
1125630010202	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
1125630010203	Fatty acid desaturase protein family subgroup, a delta-12 acyl-lipid desaturase-like, DesA-like, yet uncharacterized subgroup of membrane fatty acid desaturase proteins found in alpha-, beta-, and gamma-proteobacteria. Sequences of this domain family...; Region: DesA_FADS-like; cd03509
1125630010204	putative di-iron ligands [ion binding]; other site
1125630010205	Meiotically up-regulated gene 113; Region: MUG113; pfam13455
1125630010206	Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765
1125630010207	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1125630010208	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
1125630010209	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1125630010210	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
1125630010211	Uncharacterized conserved protein [Function unknown]; Region: COG2308
1125630010212	trehalase; Provisional; Region: treA; PRK13271
1125630010213	Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626
1125630010214	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
1125630010215	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1125630010216	N-terminal plug; other site
1125630010217	ligand-binding site [chemical binding]; other site
1125630010218	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1125630010219	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1125630010220	catalytic residue [active]
1125630010221	Flagellar P-ring protein; Region: FlgI; cl19280
1125630010222	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cl00700
1125630010223	dimer interface [polypeptide binding]; other site
1125630010224	catalytic triad [active]
1125630010225	NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263
1125630010226	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1125630010227	TrkA-C domain; Region: TrkA_C; pfam02080
1125630010228	Transporter associated domain; Region: CorC_HlyC; smart01091
1125630010229	alanine racemase; Reviewed; Region: dadX; PRK03646
1125630010230	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
1125630010231	active site
1125630010232	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1125630010233	substrate binding site [chemical binding]; other site
1125630010234	catalytic residues [active]
1125630010235	dimer interface [polypeptide binding]; other site
1125630010236	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
1125630010237	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1125630010238	SpoVR family protein; Provisional; Region: PRK11767
1125630010239	fatty acid metabolism regulator; Provisional; Region: PRK04984
1125630010240	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1125630010241	DNA-binding site [nucleotide binding]; DNA binding site
1125630010242	FadR C-terminal domain; Region: FadR_C; pfam07840
1125630010243	sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547
1125630010244	disulfide bond formation protein B; Provisional; Region: PRK01749
1125630010245	Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615
1125630010246	hypothetical protein; Provisional; Region: PRK05170
1125630010247	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1125630010248	hypothetical protein; Provisional; Region: PRK10691
1125630010249	YcgL domain; Region: YcgL; cl01189
1125630010250	septum formation inhibitor; Reviewed; Region: minC; PRK03511
1125630010251	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
1125630010252	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
1125630010253	cell division inhibitor MinD; Provisional; Region: PRK10818
1125630010254	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
1125630010255	P-loop; other site
1125630010256	ADP binding residues [chemical binding]; other site
1125630010257	Switch I; other site
1125630010258	Switch II; other site
1125630010259	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
1125630010260	ribonuclease D; Provisional; Region: PRK10829
1125630010261	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
1125630010262	catalytic site [active]
1125630010263	putative active site [active]
1125630010264	putative substrate binding site [chemical binding]; other site
1125630010265	Helicase and RNase D C-terminal; Region: HRDC; smart00341
1125630010266	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
1125630010267	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
1125630010268	acyl-activating enzyme (AAE) consensus motif; other site
1125630010269	putative AMP binding site [chemical binding]; other site
1125630010270	putative active site [active]
1125630010271	putative CoA binding site [chemical binding]; other site
1125630010272	Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065
1125630010273	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1125630010274	Glycoprotease family; Region: Peptidase_M22; pfam00814
1125630010275	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
1125630010276	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1125630010277	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1125630010278	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
1125630010279	homotrimer interaction site [polypeptide binding]; other site
1125630010280	putative active site [active]
1125630010281	hypothetical protein; Provisional; Region: PRK05114
1125630010282	aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465
1125630010283	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1125630010284	aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553
1125630010285	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
1125630010286	putative active site [active]
1125630010287	putative CoA binding site [chemical binding]; other site
1125630010288	nudix motif; other site
1125630010289	metal binding site [ion binding]; metal-binding site
1125630010290	L-serine deaminase; Provisional; Region: PRK15023
1125630010291	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1125630010292	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
1125630010293	phage resistance protein; Provisional; Region: PRK10551
1125630010294	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
1125630010295	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1125630010296	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
1125630010297	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1125630010298	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1125630010299	Transporter associated domain; Region: CorC_HlyC; smart01091
1125630010300	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
1125630010301	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1125630010302	active pocket/dimerization site; other site
1125630010303	active site
1125630010304	phosphorylation site [posttranslational modification]
1125630010305	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
1125630010306	active site
1125630010307	phosphorylation site [posttranslational modification]
1125630010308	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
1125630010309	PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103
1125630010310	hypothetical protein; Provisional; Region: PRK02913
1125630010311	hypothetical protein; Provisional; Region: PRK11469
1125630010312	Domain of unknown function DUF; Region: DUF204; pfam02659
1125630010313	Domain of unknown function DUF; Region: DUF204; pfam02659
1125630010314	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1125630010315	S-adenosylmethionine binding site [chemical binding]; other site
1125630010316	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
1125630010317	Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717
1125630010318	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1125630010319	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1125630010320	DNA-binding site [nucleotide binding]; DNA binding site
1125630010321	RNA-binding motif; other site
1125630010322	YebO-like protein; Region: YebO; pfam13974
1125630010323	YobH-like protein; Region: YobH; pfam13996
1125630010324	DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090
1125630010325	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1125630010326	dimerization interface [polypeptide binding]; other site
1125630010327	putative Zn2+ binding site [ion binding]; other site
1125630010328	putative DNA binding site [nucleotide binding]; other site
1125630010329	Bacterial transcriptional regulator; Region: IclR; pfam01614
1125630010330	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630010331	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1125630010332	putative substrate translocation pore; other site
1125630010333	heat shock protein HtpX; Provisional; Region: PRK05457
1125630010334	carboxy-terminal protease; Provisional; Region: PRK11186
1125630010335	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1125630010336	protein binding site [polypeptide binding]; other site
1125630010337	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1125630010338	Catalytic dyad [active]
1125630010339	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
1125630010340	ProP expression regulator; Provisional; Region: PRK04950
1125630010341	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
1125630010342	Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995
1125630010343	Paraquat-inducible protein A; Region: PqiA; pfam04403
1125630010344	Paraquat-inducible protein A; Region: PqiA; pfam04403
1125630010345	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
1125630010346	mce related protein; Region: MCE; pfam02470
1125630010347	mce related protein; Region: MCE; pfam02470
1125630010348	mce related protein; Region: MCE; pfam02470
1125630010349	mce related protein; Region: MCE; pfam02470
1125630010350	mce related protein; Region: MCE; pfam02470
1125630010351	mce related protein; Region: MCE; pfam02470
1125630010352	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
1125630010353	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1125630010354	S-adenosylmethionine binding site [chemical binding]; other site
1125630010355	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; cl19835
1125630010356	Protein of unknown function (DUF1480); Region: DUF1480; pfam07351
1125630010357	Protein of unknown function (DUF1482); Region: DUF1482; pfam07358
1125630010358	serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439
1125630010359	Protein of unknown function (DUF535); Region: DUF535; pfam04393
1125630010360	Protein of unknown function (DUF2511); Region: DUF2511; pfam10709
1125630010361	Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276
1125630010362	CopC domain; Region: CopC; cl01012
1125630010363	DNA polymerase III subunit theta; Reviewed; Region: PRK10969
1125630010364	exodeoxyribonuclease X; Provisional; Region: PRK07983
1125630010365	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1125630010366	active site
1125630010367	catalytic site [active]
1125630010368	substrate binding site [chemical binding]; other site
1125630010369	potential frameshift: common BLAST hit: gi|152970908|ref|YP_001336017.1| protease 2
1125630010370	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1125630010371	Prolyl oligopeptidase, N-terminal beta-propeller domain; Region: Peptidase_S9_N; pfam02897
1125630010372	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
1125630010373	Protein of unknown function (DUF533); Region: DUF533; pfam04391
1125630010374	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
1125630010375	putative metal binding site [ion binding]; other site
1125630010376	YebG protein; Region: YebG; cl01217
1125630010377	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
1125630010378	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1125630010379	ATP-grasp domain; Region: ATP-grasp; pfam02222
1125630010380	Entner-Doudoroff aldolase; Region: eda; TIGR01182
1125630010381	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
1125630010382	active site
1125630010383	intersubunit interface [polypeptide binding]; other site
1125630010384	catalytic residue [active]
1125630010385	potential frameshift: common BLAST hit: gi|238895427|ref|YP_002920162.1| phosphogluconate dehydratase
1125630010386	Dehydratase family; Region: ILVD_EDD; cl00340
1125630010387	potential frameshift: common BLAST hit: gi|288934619|ref|YP_003438678.1| 6-phosphogluconate dehydratase
1125630010388	Dehydratase family; Region: ILVD_EDD; cl00340
1125630010389	Dehydratase family; Region: ILVD_EDD; cl00340
1125630010390	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
1125630010391	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1125630010392	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1125630010393	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
1125630010394	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1125630010395	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1125630010396	putative active site [active]
1125630010397	pyruvate kinase; Provisional; Region: PRK05826
1125630010398	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288
1125630010399	domain interfaces; other site
1125630010400	active site
1125630010401	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1125630010402	putative acyl-acceptor binding pocket; other site
1125630010403	putative peptidase; Provisional; Region: PRK11649
1125630010404	Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525
1125630010405	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1125630010406	Peptidase family M23; Region: Peptidase_M23; pfam01551
1125630010407	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
1125630010408	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
1125630010409	metal binding site [ion binding]; metal-binding site
1125630010410	high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544
1125630010411	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1125630010412	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1125630010413	ABC-ATPase subunit  interface; other site
1125630010414	dimer interface [polypeptide binding]; other site
1125630010415	putative PBP binding regions; other site
1125630010416	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1125630010417	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1125630010418	Walker A motif; other site
1125630010419	ATP binding site [chemical binding]; other site
1125630010420	Walker B motif; other site
1125630010421	arginine finger; other site
1125630010422	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1125630010423	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
1125630010424	RuvA N terminal domain; Region: RuvA_N; pfam01330
1125630010425	Helix-hairpin-helix domain; Region: HHH_5; pfam14520
1125630010426	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
1125630010427	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
1125630010428	active site
1125630010429	putative DNA-binding cleft [nucleotide binding]; other site
1125630010430	dimer interface [polypeptide binding]; other site
1125630010431	hypothetical protein; Validated; Region: PRK00110
1125630010432	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
1125630010433	nudix motif; other site
1125630010434	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1125630010435	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1125630010436	dimer interface [polypeptide binding]; other site
1125630010437	anticodon binding site; other site
1125630010438	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1125630010439	homodimer interface [polypeptide binding]; other site
1125630010440	motif 1; other site
1125630010441	active site
1125630010442	motif 2; other site
1125630010443	GAD domain; Region: GAD; pfam02938
1125630010444	motif 3; other site
1125630010445	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1125630010446	catalytic triad [active]
1125630010447	conserved cis-peptide bond; other site
1125630010448	hypothetical protein; Provisional; Region: PRK10302
1125630010449	Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788
1125630010450	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1125630010451	S-adenosylmethionine binding site [chemical binding]; other site
1125630010452	tRNA (mo5U34)-methyltransferase; Region: TIGR00452
1125630010453	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1125630010454	S-adenosylmethionine binding site [chemical binding]; other site
1125630010455	copper homeostasis protein CutC; Provisional; Region: PRK11572
1125630010456	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268
1125630010457	putative metal binding site [ion binding]; other site
1125630010458	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
1125630010459	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
1125630010460	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1125630010461	active site
1125630010462	HIGH motif; other site
1125630010463	KMSK motif region; other site
1125630010464	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
1125630010465	tRNA binding surface [nucleotide binding]; other site
1125630010466	anticodon binding site; other site
1125630010467	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
1125630010468	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
1125630010469	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630010470	putative substrate translocation pore; other site
1125630010471	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1125630010472	Ligand Binding Site [chemical binding]; other site
1125630010473	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
1125630010474	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
1125630010475	active site
1125630010476	homotetramer interface [polypeptide binding]; other site
1125630010477	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187
1125630010478	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
1125630010479	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1125630010480	active site
1125630010481	motif I; other site
1125630010482	motif II; other site
1125630010483	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1125630010484	TM-ABC transporter signature motif; other site
1125630010485	L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288
1125630010486	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1125630010487	Walker A/P-loop; other site
1125630010488	ATP binding site [chemical binding]; other site
1125630010489	Q-loop/lid; other site
1125630010490	ABC transporter signature motif; other site
1125630010491	Walker B; other site
1125630010492	D-loop; other site
1125630010493	H-loop/switch region; other site
1125630010494	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1125630010495	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
1125630010496	Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540
1125630010497	ligand binding site [chemical binding]; other site
1125630010498	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
1125630010499	Ferritin-like domain; Region: Ferritin; pfam00210
1125630010500	ferroxidase diiron center [ion binding]; other site
1125630010501	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
1125630010502	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630010503	putative substrate translocation pore; other site
1125630010504	Protein of unknown function (DUF2766); Region: DUF2766; pfam10964
1125630010505	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630010506	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1125630010507	putative substrate translocation pore; other site
1125630010508	hypothetical protein; Provisional; Region: PRK09273
1125630010509	Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698
1125630010510	Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408
1125630010511	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
1125630010512	Ferritin-like domain; Region: Ferritin; pfam00210
1125630010513	ferroxidase diiron center [ion binding]; other site
1125630010514	probable metal-binding protein; Region: matur_matur; TIGR03853
1125630010515	tyrosine transporter TyrP; Provisional; Region: PRK15132
1125630010516	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
1125630010517	hypothetical protein; Provisional; Region: PRK10396
1125630010518	Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173
1125630010519	SEC-C motif; Region: SEC-C; cl19389
1125630010520	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1125630010521	inhibitor site; inhibition site
1125630010522	active site
1125630010523	dimer interface [polypeptide binding]; other site
1125630010524	catalytic residue [active]
1125630010525	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
1125630010526	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1125630010527	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1125630010528	GIY-YIG motif/motif A; other site
1125630010529	active site
1125630010530	catalytic site [active]
1125630010531	putative DNA binding site [nucleotide binding]; other site
1125630010532	metal binding site [ion binding]; metal-binding site
1125630010533	UvrB/uvrC motif; Region: UVR; pfam02151
1125630010534	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1125630010535	Helix-hairpin-helix domain; Region: HHH_5; pfam14520
1125630010536	response regulator; Provisional; Region: PRK09483
1125630010537	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1125630010538	active site
1125630010539	phosphorylation site [posttranslational modification]
1125630010540	intermolecular recognition site; other site
1125630010541	dimerization interface [polypeptide binding]; other site
1125630010542	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1125630010543	DNA binding residues [nucleotide binding]
1125630010544	dimerization interface [polypeptide binding]; other site
1125630010545	hypothetical protein; Provisional; Region: PRK10613
1125630010546	DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188
1125630010547	Autoinducer binding domain; Region: Autoind_bind; pfam03472
1125630010548	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1125630010549	DNA binding residues [nucleotide binding]
1125630010550	dimerization interface [polypeptide binding]; other site
1125630010551	putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264
1125630010552	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1125630010553	Walker A/P-loop; other site
1125630010554	ATP binding site [chemical binding]; other site
1125630010555	Q-loop/lid; other site
1125630010556	ABC transporter signature motif; other site
1125630010557	Walker B; other site
1125630010558	D-loop; other site
1125630010559	H-loop/switch region; other site
1125630010560	amino acid ABC transporter permease; Provisional; Region: PRK15100
1125630010561	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630010562	dimer interface [polypeptide binding]; other site
1125630010563	conserved gate region; other site
1125630010564	putative PBP binding loops; other site
1125630010565	ABC-ATPase subunit interface; other site
1125630010566	Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449
1125630010567	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630010568	catalytic residue [active]
1125630010569	cystine transporter subunit; Provisional; Region: PRK11260
1125630010570	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1125630010571	substrate binding pocket [chemical binding]; other site
1125630010572	membrane-bound complex binding site; other site
1125630010573	hinge residues; other site
1125630010574	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
1125630010575	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
1125630010576	active site
1125630010577	Na/Ca binding site [ion binding]; other site
1125630010578	catalytic site [active]
1125630010579	lipoprotein; Provisional; Region: PRK10397
1125630010580	colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411
1125630010581	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1125630010582	DNA binding residues [nucleotide binding]
1125630010583	dimerization interface [polypeptide binding]; other site
1125630010584	hypothetical protein; Provisional; Region: PRK10708
1125630010585	Protein of unknown function (DUF2525); Region: DUF2525; pfam10733
1125630010586	putative diguanylate cyclase YedQ; Provisional; Region: PRK15426
1125630010587	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1125630010588	metal binding site [ion binding]; metal-binding site
1125630010589	active site
1125630010590	I-site; other site
1125630010591	hypothetical protein; Provisional; Region: PRK10062
1125630010592	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
1125630010593	EamA-like transporter family; Region: EamA; pfam00892
1125630010594	EamA-like transporter family; Region: EamA; pfam00892
1125630010595	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
1125630010596	additional DNA contacts [nucleotide binding]; other site
1125630010597	mismatch recognition site; other site
1125630010598	active site
1125630010599	zinc binding site [ion binding]; other site
1125630010600	DNA intercalation site [nucleotide binding]; other site
1125630010601	DNA cytosine methylase; Provisional; Region: PRK10458
1125630010602	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1125630010603	cofactor binding site; other site
1125630010604	DNA binding site [nucleotide binding]
1125630010605	substrate interaction site [chemical binding]; other site
1125630010606	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
1125630010607	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1125630010608	Zn2+ binding site [ion binding]; other site
1125630010609	Mg2+ binding site [ion binding]; other site
1125630010610	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1125630010611	trimer interface [polypeptide binding]; other site
1125630010612	eyelet of channel; other site
1125630010613	DgsA anti-repressor MtfA; Provisional; Region: PRK15410
1125630010614	YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198
1125630010615	homotrimer interaction site [polypeptide binding]; other site
1125630010616	putative active site [active]
1125630010617	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630010618	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630010619	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
1125630010620	putative effector binding pocket; other site
1125630010621	putative dimerization interface [polypeptide binding]; other site
1125630010622	L,D-transpeptidase; Provisional; Region: PRK10190
1125630010623	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1125630010624	transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679
1125630010625	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1125630010626	dimerization interface [polypeptide binding]; other site
1125630010627	nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233
1125630010628	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630010629	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
1125630010630	putative dimerization interface [polypeptide binding]; other site
1125630010631	integrase; Provisional; Region: PRK09692
1125630010632	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
1125630010633	active site
1125630010634	Int/Topo IB signature motif; other site
1125630010635	salicylate synthase Irp9; Reviewed; Region: PRK06772
1125630010636	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1125630010637	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630010638	putative substrate translocation pore; other site
1125630010639	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1125630010640	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1125630010641	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1125630010642	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1125630010643	Walker A/P-loop; other site
1125630010644	ATP binding site [chemical binding]; other site
1125630010645	Q-loop/lid; other site
1125630010646	ABC transporter signature motif; other site
1125630010647	Walker B; other site
1125630010648	D-loop; other site
1125630010649	H-loop/switch region; other site
1125630010650	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1125630010651	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1125630010652	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1125630010653	Walker A/P-loop; other site
1125630010654	ATP binding site [chemical binding]; other site
1125630010655	Q-loop/lid; other site
1125630010656	ABC transporter signature motif; other site
1125630010657	Walker B; other site
1125630010658	D-loop; other site
1125630010659	H-loop/switch region; other site
1125630010660	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1125630010661	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630010662	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
1125630010663	Condensation domain; Region: Condensation; pfam00668
1125630010664	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1125630010665	Nonribosomal peptide synthase; Region: NRPS; pfam08415
1125630010666	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
1125630010667	acyl-activating enzyme (AAE) consensus motif; other site
1125630010668	AMP binding site [chemical binding]; other site
1125630010669	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1125630010670	S-adenosylmethionine binding site [chemical binding]; other site
1125630010671	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1125630010672	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1125630010673	Condensation domain; Region: Condensation; pfam00668
1125630010674	Nonribosomal peptide synthase; Region: NRPS; pfam08415
1125630010675	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1125630010676	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1125630010677	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1125630010678	active site
1125630010679	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1125630010680	Methyltransferase domain; Region: Methyltransf_12; pfam08242
1125630010681	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1125630010682	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
1125630010683	short chain dehydrogenase; Region: adh_short; pfam00106
1125630010684	NADP binding site [chemical binding]; other site
1125630010685	active site
1125630010686	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1125630010687	Condensation domain; Region: Condensation; cl19241
1125630010688	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1125630010689	Nonribosomal peptide synthase; Region: NRPS; pfam08415
1125630010690	Methyltransferase domain; Region: Methyltransf_12; pfam08242
1125630010691	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1125630010692	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
1125630010693	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1125630010694	Oxidoreductase (NAD-binding), involved in siderophore biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PchG; COG4693
1125630010695	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1125630010696	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
1125630010697	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1125630010698	Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021
1125630010699	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
1125630010700	acyl-activating enzyme (AAE) consensus motif; other site
1125630010701	active site
1125630010702	AMP binding site [chemical binding]; other site
1125630010703	substrate binding site [chemical binding]; other site
1125630010704	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1125630010705	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1125630010706	N-terminal plug; other site
1125630010707	ligand-binding site [chemical binding]; other site
1125630010708	Protein of unknown function (DUF2857); Region: DUF2857; pfam11198
1125630010709	Haemolysin expression modulating protein; Region: HHA; cl11501
1125630010710	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1125630010711	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1125630010712	catalytic residue [active]
1125630010713	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
1125630010714	type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929
1125630010715	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
1125630010716	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1125630010717	Walker B motif; other site
1125630010718	Type IV secretion system proteins; Region: T4SS; pfam07996
1125630010719	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610
1125630010720	VirB8 protein; Region: VirB8; pfam04335
1125630010721	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
1125630010722	VirB7 interaction site; other site
1125630010723	Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948
1125630010724	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
1125630010725	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1125630010726	Walker A motif; other site
1125630010727	ATP binding site [chemical binding]; other site
1125630010728	Walker B motif; other site
1125630010729	Domain of unknown function DUF87; Region: DUF87; cl19135
1125630010730	AAA-like domain; Region: AAA_10; pfam12846
1125630010731	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
1125630010732	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
1125630010733	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
1125630010734	Restriction endonuclease; Region: Mrr_cat; pfam04471
1125630010735	Restriction endonuclease; Region: Mrr_cat; cl19295
1125630010736	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
1125630010737	AAA domain; Region: AAA_23; pfam13476
1125630010738	Walker A/P-loop; other site
1125630010739	ATP binding site [chemical binding]; other site
1125630010740	Cortexillin I, coiled coil; Region: Cortex-I_coil; pfam09304
1125630010741	AAA ATPase domain; Region: AAA_15; pfam13175
1125630010742	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1125630010743	Walker A/P-loop; other site
1125630010744	ATP binding site [chemical binding]; other site
1125630010745	AAA domain; Region: AAA_21; pfam13304
1125630010746	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
1125630010747	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1125630010748	active site
1125630010749	NTP binding site [chemical binding]; other site
1125630010750	nucleic acid binding site [nucleotide binding]; other site
1125630010751	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1125630010752	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
1125630010753	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1125630010754	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1125630010755	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
1125630010756	NADP binding site [chemical binding]; other site
1125630010757	dimer interface [polypeptide binding]; other site
1125630010758	Putative lysophospholipase; Region: Hydrolase_4; cl19140
1125630010759	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1125630010760	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
1125630010761	Polymyxin resistance protein PmrD; Region: PmrD; pfam11183
1125630010762	AMP nucleosidase; Provisional; Region: PRK08292
1125630010763	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
1125630010764	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
1125630010765	MATE family multidrug exporter; Provisional; Region: PRK10189
1125630010766	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
1125630010767	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1125630010768	active site
1125630010769	substrate binding site [chemical binding]; other site
1125630010770	ATP binding site [chemical binding]; other site
1125630010771	GAF domain; Region: GAF; pfam01590
1125630010772	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1125630010773	metal binding site [ion binding]; metal-binding site
1125630010774	active site
1125630010775	I-site; other site
1125630010776	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1125630010777	Putative lysophospholipase; Region: Hydrolase_4; cl19140
1125630010778	TAP-like protein; Region: Abhydrolase_4; pfam08386
1125630010779	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1125630010780	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630010781	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1125630010782	dimerization interface [polypeptide binding]; other site
1125630010783	substrate binding pocket [chemical binding]; other site
1125630010784	Domain of unknown function (DUF1869); Region: DUF1869; pfam08956
1125630010785	Domain of unknown function (DUF1971); Region: DUF1971; cl17717
1125630010786	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1125630010787	metal binding site [ion binding]; metal-binding site
1125630010788	active site
1125630010789	I-site; other site
1125630010790	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1125630010791	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
1125630010792	shikimate transporter; Provisional; Region: PRK09952
1125630010793	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630010794	putative substrate translocation pore; other site
1125630010795	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1125630010796	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630010797	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630010798	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1125630010799	putative effector binding pocket; other site
1125630010800	dimerization interface [polypeptide binding]; other site
1125630010801	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
1125630010802	Tautomerase enzyme; Region: Tautomerase_2; pfam14552
1125630010803	HPP family; Region: HPP; pfam04982
1125630010804	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
1125630010805	NAD binding site [chemical binding]; other site
1125630010806	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
1125630010807	putative dimer interface [polypeptide binding]; other site
1125630010808	active site pocket [active]
1125630010809	putative cataytic base [active]
1125630010810	cobalamin synthase; Reviewed; Region: cobS; PRK00235
1125630010811	hypothetical protein; Provisional; Region: PRK05423
1125630010812	Predicted membrane protein [Function unknown]; Region: COG1289
1125630010813	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1125630010814	DNA gyrase inhibitor; Provisional; Region: PRK10016
1125630010815	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1125630010816	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1125630010817	putative active site [active]
1125630010818	putative NTP binding site [chemical binding]; other site
1125630010819	putative nucleic acid binding site [nucleotide binding]; other site
1125630010820	D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397
1125630010821	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1125630010822	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
1125630010823	exonuclease I; Provisional; Region: sbcB; PRK11779
1125630010824	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
1125630010825	active site
1125630010826	catalytic site [active]
1125630010827	substrate binding site [chemical binding]; other site
1125630010828	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
1125630010829	elongation factor G; Reviewed; Region: PRK00007
1125630010830	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1125630010831	G1 box; other site
1125630010832	putative GEF interaction site [polypeptide binding]; other site
1125630010833	GTP/Mg2+ binding site [chemical binding]; other site
1125630010834	Switch I region; other site
1125630010835	G2 box; other site
1125630010836	G3 box; other site
1125630010837	Switch II region; other site
1125630010838	G4 box; other site
1125630010839	G5 box; other site
1125630010840	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1125630010841	Elongation Factor G, domain II; Region: EFG_II; pfam14492
1125630010842	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1125630010843	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1125630010844	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1125630010845	dimerization interface [polypeptide binding]; other site
1125630010846	putative DNA binding site [nucleotide binding]; other site
1125630010847	putative Zn2+ binding site [ion binding]; other site
1125630010848	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1125630010849	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
1125630010850	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630010851	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630010852	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1125630010853	dimerization interface [polypeptide binding]; other site
1125630010854	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1125630010855	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
1125630010856	putative NAD(P) binding site [chemical binding]; other site
1125630010857	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
1125630010858	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
1125630010859	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
1125630010860	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
1125630010861	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1125630010862	NAD binding site [chemical binding]; other site
1125630010863	dimerization interface [polypeptide binding]; other site
1125630010864	product binding site; other site
1125630010865	substrate binding site [chemical binding]; other site
1125630010866	zinc binding site [ion binding]; other site
1125630010867	catalytic residues [active]
1125630010868	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
1125630010869	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1125630010870	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630010871	homodimer interface [polypeptide binding]; other site
1125630010872	catalytic residue [active]
1125630010873	imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446
1125630010874	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1125630010875	active site
1125630010876	motif I; other site
1125630010877	motif II; other site
1125630010878	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
1125630010879	putative active site pocket [active]
1125630010880	4-fold oligomerization interface [polypeptide binding]; other site
1125630010881	metal binding residues [ion binding]; metal-binding site
1125630010882	3-fold/trimer interface [polypeptide binding]; other site
1125630010883	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142
1125630010884	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
1125630010885	putative active site [active]
1125630010886	oxyanion strand; other site
1125630010887	catalytic triad [active]
1125630010888	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
1125630010889	catalytic residues [active]
1125630010890	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
1125630010891	substrate binding site [chemical binding]; other site
1125630010892	glutamase interaction surface [polypeptide binding]; other site
1125630010893	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
1125630010894	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
1125630010895	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
1125630010896	metal binding site [ion binding]; metal-binding site
1125630010897	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1125630010898	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1125630010899	active site
1125630010900	Coiled-coil receptor-binding R-domain of colicin E2; Region: E2R135; pfam11570
1125630010901	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
1125630010902	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1125630010903	putative ADP-binding pocket [chemical binding]; other site
1125630010904	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1125630010905	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1125630010906	active site
1125630010907	UDP-galactopyranose mutase; Region: GLF; pfam03275
1125630010908	Domain of unknown function (DUF4422); Region: DUF4422; pfam14393
1125630010909	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
1125630010910	Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442
1125630010911	Ligand binding site; other site
1125630010912	metal-binding site
1125630010913	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
1125630010914	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
1125630010915	Walker A/P-loop; other site
1125630010916	ATP binding site [chemical binding]; other site
1125630010917	Q-loop/lid; other site
1125630010918	ABC transporter signature motif; other site
1125630010919	Walker B; other site
1125630010920	D-loop; other site
1125630010921	H-loop/switch region; other site
1125630010922	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
1125630010923	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1125630010924	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
1125630010925	putative NAD(P) binding site [chemical binding]; other site
1125630010926	active site
1125630010927	putative substrate binding site [chemical binding]; other site
1125630010928	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
1125630010929	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126
1125630010930	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1125630010931	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1125630010932	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
1125630010933	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
1125630010934	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
1125630010935	NADP binding site [chemical binding]; other site
1125630010936	active site
1125630010937	putative substrate binding site [chemical binding]; other site
1125630010938	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
1125630010939	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
1125630010940	substrate binding site; other site
1125630010941	tetramer interface; other site
1125630010942	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1125630010943	dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217
1125630010944	NAD binding site [chemical binding]; other site
1125630010945	substrate binding site [chemical binding]; other site
1125630010946	homodimer interface [polypeptide binding]; other site
1125630010947	active site
1125630010948	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
1125630010949	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
1125630010950	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
1125630010951	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
1125630010952	colanic acid exporter; Provisional; Region: PRK10459
1125630010953	Protein of unknown function (DUF563); Region: DUF563; pfam04577
1125630010954	Proline dehydrogenase; Region: Pro_dh; pfam01619
1125630010955	EpsG family; Region: EpsG; pfam14897
1125630010956	Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188
1125630010957	Right handed beta helix region; Region: Beta_helix; pfam13229
1125630010958	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1125630010959	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1125630010960	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1125630010961	undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204
1125630010962	CoA binding domain; Region: CoA_binding; cl17356
1125630010963	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1125630010964	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
1125630010965	cryptic autophosphorylating protein tyrosine kinase Etk; Provisional; Region: PRK09841
1125630010966	Chain length determinant protein; Region: Wzz; pfam02706
1125630010967	Protein of unknown function (DUF1002); Region: DUF1002; cl19854
1125630010968	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
1125630010969	AAA domain; Region: AAA_31; pfam13614
1125630010970	polysaccharide export protein Wza; Provisional; Region: PRK15078
1125630010971	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
1125630010972	SLBB domain; Region: SLBB; pfam10531
1125630010973	Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052
1125630010974	Transposase domain (DUF772); Region: DUF772; pfam05598
1125630010975	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
1125630010976	DDE superfamily endonuclease; Region: DDE_Tnp_4; cl17710
1125630010977	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1125630010978	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1125630010979	Acid phosphatase homologues; Region: acidPPc; smart00014
1125630010980	active site
1125630010981	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1125630010982	active site
1125630010983	tetramer interface; other site
1125630010984	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
1125630010985	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1125630010986	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1125630010987	Transporter associated domain; Region: CorC_HlyC; smart01091
1125630010988	putative assembly protein; Provisional; Region: PRK10833
1125630010989	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1125630010990	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1125630010991	trimer interface [polypeptide binding]; other site
1125630010992	active site
1125630010993	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
1125630010994	ATP-binding site [chemical binding]; other site
1125630010995	Sugar specificity; other site
1125630010996	Pyrimidine base specificity; other site
1125630010997	3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308
1125630010998	AlkA N-terminal domain; Region: AlkA_N; pfam06029
1125630010999	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1125630011000	minor groove reading motif; other site
1125630011001	helix-hairpin-helix signature motif; other site
1125630011002	substrate binding pocket [chemical binding]; other site
1125630011003	active site
1125630011004	putative chaperone; Provisional; Region: PRK11678
1125630011005	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
1125630011006	nucleotide binding site [chemical binding]; other site
1125630011007	putative NEF/HSP70 interaction site [polypeptide binding]; other site
1125630011008	SBD interface [polypeptide binding]; other site
1125630011009	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
1125630011010	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
1125630011011	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1125630011012	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1125630011013	dimer interface [polypeptide binding]; other site
1125630011014	phosphorylation site [posttranslational modification]
1125630011015	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1125630011016	ATP binding site [chemical binding]; other site
1125630011017	Mg2+ binding site [ion binding]; other site
1125630011018	G-X-G motif; other site
1125630011019	DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816
1125630011020	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1125630011021	active site
1125630011022	phosphorylation site [posttranslational modification]
1125630011023	intermolecular recognition site; other site
1125630011024	dimerization interface [polypeptide binding]; other site
1125630011025	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
1125630011026	DNA binding site [nucleotide binding]
1125630011027	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1125630011028	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
1125630011029	DNA binding residues [nucleotide binding]
1125630011030	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1125630011031	multidrug efflux system subunit MdtA; Provisional; Region: PRK11556
1125630011032	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1125630011033	HlyD family secretion protein; Region: HlyD_3; pfam13437
1125630011034	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
1125630011035	MMPL family; Region: MMPL; cl14618
1125630011036	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
1125630011037	MMPL family; Region: MMPL; cl14618
1125630011038	putative transporter; Provisional; Region: PRK10504
1125630011039	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630011040	putative substrate translocation pore; other site
1125630011041	signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549
1125630011042	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1125630011043	dimerization interface [polypeptide binding]; other site
1125630011044	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1125630011045	dimer interface [polypeptide binding]; other site
1125630011046	phosphorylation site [posttranslational modification]
1125630011047	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1125630011048	ATP binding site [chemical binding]; other site
1125630011049	Mg2+ binding site [ion binding]; other site
1125630011050	G-X-G motif; other site
1125630011051	DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710
1125630011052	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1125630011053	active site
1125630011054	phosphorylation site [posttranslational modification]
1125630011055	intermolecular recognition site; other site
1125630011056	dimerization interface [polypeptide binding]; other site
1125630011057	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1125630011058	DNA binding site [nucleotide binding]
1125630011059	putative protease; Provisional; Region: PRK15452
1125630011060	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1125630011061	lipid kinase; Reviewed; Region: PRK13054
1125630011062	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1125630011063	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1125630011064	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1125630011065	Walker A/P-loop; other site
1125630011066	ATP binding site [chemical binding]; other site
1125630011067	Q-loop/lid; other site
1125630011068	ABC transporter signature motif; other site
1125630011069	Walker B; other site
1125630011070	D-loop; other site
1125630011071	H-loop/switch region; other site
1125630011072	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1125630011073	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1125630011074	Walker A/P-loop; other site
1125630011075	ATP binding site [chemical binding]; other site
1125630011076	Q-loop/lid; other site
1125630011077	ABC transporter signature motif; other site
1125630011078	Walker B; other site
1125630011079	D-loop; other site
1125630011080	H-loop/switch region; other site
1125630011081	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1125630011082	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1125630011083	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1125630011084	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630011085	dimer interface [polypeptide binding]; other site
1125630011086	conserved gate region; other site
1125630011087	putative PBP binding loops; other site
1125630011088	ABC-ATPase subunit interface; other site
1125630011089	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1125630011090	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630011091	dimer interface [polypeptide binding]; other site
1125630011092	conserved gate region; other site
1125630011093	putative PBP binding loops; other site
1125630011094	ABC-ATPase subunit interface; other site
1125630011095	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1125630011096	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
1125630011097	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1125630011098	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 4. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_4; cd03329
1125630011099	putative active site pocket [active]
1125630011100	metal binding site [ion binding]; metal-binding site
1125630011101	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
1125630011102	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1125630011103	active site
1125630011104	motif I; other site
1125630011105	motif II; other site
1125630011106	polyol permease family; Region: 2A0118; TIGR00897
1125630011107	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630011108	putative substrate translocation pore; other site
1125630011109	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
1125630011110	N- and C-terminal domain interface [polypeptide binding]; other site
1125630011111	D-xylulose kinase; Region: XylB; TIGR01312
1125630011112	active site
1125630011113	MgATP binding site [chemical binding]; other site
1125630011114	catalytic site [active]
1125630011115	metal binding site [ion binding]; metal-binding site
1125630011116	xylulose binding site [chemical binding]; other site
1125630011117	homodimer interface [polypeptide binding]; other site
1125630011118	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1125630011119	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
1125630011120	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1125630011121	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1125630011122	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
1125630011123	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1125630011124	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1125630011125	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1125630011126	DNA binding site [nucleotide binding]
1125630011127	domain linker motif; other site
1125630011128	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
1125630011129	dimerization interface [polypeptide binding]; other site
1125630011130	ligand binding site [chemical binding]; other site
1125630011131	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1125630011132	classical (c) SDRs; Region: SDR_c; cd05233
1125630011133	NAD(P) binding site [chemical binding]; other site
1125630011134	active site
1125630011135	Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782
1125630011136	FGGY-family pentulose kinase; Region: 5C_CHO_kinase; TIGR01315
1125630011137	N- and C-terminal domain interface [polypeptide binding]; other site
1125630011138	active site
1125630011139	MgATP binding site [chemical binding]; other site
1125630011140	catalytic site [active]
1125630011141	metal binding site [ion binding]; metal-binding site
1125630011142	carbohydrate binding site [chemical binding]; other site
1125630011143	putative homodimer interface [polypeptide binding]; other site
1125630011144	polyol permease family; Region: 2A0118; TIGR00897
1125630011145	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630011146	putative substrate translocation pore; other site
1125630011147	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
1125630011148	putative active site; other site
1125630011149	catalytic residue [active]
1125630011150	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1125630011151	dimer interface [polypeptide binding]; other site
1125630011152	substrate binding site [chemical binding]; other site
1125630011153	ATP binding site [chemical binding]; other site
1125630011154	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
1125630011155	substrate binding site [chemical binding]; other site
1125630011156	multimerization interface [polypeptide binding]; other site
1125630011157	ATP binding site [chemical binding]; other site
1125630011158	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1125630011159	Ligand Binding Site [chemical binding]; other site
1125630011160	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630011161	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630011162	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1125630011163	dimerization interface [polypeptide binding]; other site
1125630011164	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
1125630011165	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1125630011166	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1125630011167	active site
1125630011168	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1125630011169	Sulfate transporter family; Region: Sulfate_transp; cl19250
1125630011170	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630011171	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630011172	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1125630011173	putative effector binding pocket; other site
1125630011174	dimerization interface [polypeptide binding]; other site
1125630011175	Domain of unknown function (DUF3315); Region: DUF3315; cl02275
1125630011176	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1125630011177	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1125630011178	Coenzyme A binding pocket [chemical binding]; other site
1125630011179	potential frameshift: common BLAST hit: gi|238895685|ref|YP_002920420.1| putative ATPase
1125630011180	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1125630011181	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1125630011182	antiporter inner membrane protein; Provisional; Region: PRK11670
1125630011183	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
1125630011184	Walker A motif; other site
1125630011185	NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512
1125630011186	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
1125630011187	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1125630011188	active site
1125630011189	KMSKS motif; other site
1125630011190	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1125630011191	tRNA binding surface [nucleotide binding]; other site
1125630011192	anticodon binding site; other site
1125630011193	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
1125630011194	dimer interface [polypeptide binding]; other site
1125630011195	putative tRNA-binding site [nucleotide binding]; other site
1125630011196	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807
1125630011197	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
1125630011198	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
1125630011199	putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697
1125630011200	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1125630011201	active site
1125630011202	phosphorylation site [posttranslational modification]
1125630011203	intermolecular recognition site; other site
1125630011204	dimerization interface [polypeptide binding]; other site
1125630011205	LytTr DNA-binding domain; Region: LytTR; pfam04397
1125630011206	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
1125630011207	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1125630011208	GAF domain; Region: GAF; pfam01590
1125630011209	Histidine kinase; Region: His_kinase; pfam06580
1125630011210	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1125630011211	ATP binding site [chemical binding]; other site
1125630011212	Mg2+ binding site [ion binding]; other site
1125630011213	G-X-G motif; other site
1125630011214	hypothetical protein; Provisional; Region: PRK13681
1125630011215	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1125630011216	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630011217	dimer interface [polypeptide binding]; other site
1125630011218	conserved gate region; other site
1125630011219	putative PBP binding loops; other site
1125630011220	ABC-ATPase subunit interface; other site
1125630011221	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
1125630011222	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1125630011223	Walker A/P-loop; other site
1125630011224	ATP binding site [chemical binding]; other site
1125630011225	Q-loop/lid; other site
1125630011226	ABC transporter signature motif; other site
1125630011227	Walker B; other site
1125630011228	D-loop; other site
1125630011229	H-loop/switch region; other site
1125630011230	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
1125630011231	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630011232	dimer interface [polypeptide binding]; other site
1125630011233	conserved gate region; other site
1125630011234	putative PBP binding loops; other site
1125630011235	ABC-ATPase subunit interface; other site
1125630011236	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
1125630011237	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
1125630011238	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1125630011239	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
1125630011240	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
1125630011241	D-lactate dehydrogenase; Provisional; Region: PRK11183
1125630011242	FAD binding domain; Region: FAD_binding_4; cl19922
1125630011243	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
1125630011244	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1125630011245	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1125630011246	Coenzyme A binding pocket [chemical binding]; other site
1125630011247	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
1125630011248	D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669
1125630011249	Protein of unknown function (DUF1282); Region: DUF1282; pfam06930
1125630011250	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1125630011251	multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459
1125630011252	Outer membrane efflux protein; Region: OEP; pfam02321
1125630011253	Outer membrane efflux protein; Region: OEP; pfam02321
1125630011254	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046
1125630011255	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232
1125630011256	PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824
1125630011257	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1125630011258	active site turn [active]
1125630011259	phosphorylation site [posttranslational modification]
1125630011260	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1125630011261	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
1125630011262	HPr interaction site; other site
1125630011263	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1125630011264	active site
1125630011265	phosphorylation site [posttranslational modification]
1125630011266	transcriptional antiterminator BglG; Provisional; Region: PRK09772
1125630011267	CAT RNA binding domain; Region: CAT_RBD; smart01061
1125630011268	PRD domain; Region: PRD; pfam00874
1125630011269	PRD domain; Region: PRD; pfam00874
1125630011270	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
1125630011271	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
1125630011272	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1125630011273	FMN binding site [chemical binding]; other site
1125630011274	active site
1125630011275	catalytic residues [active]
1125630011276	substrate binding site [chemical binding]; other site
1125630011277	hypothetical protein; Provisional; Region: PRK01821
1125630011278	hypothetical protein; Provisional; Region: PRK10711
1125630011279	cytidine deaminase; Provisional; Region: PRK09027
1125630011280	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
1125630011281	active site
1125630011282	catalytic motif [active]
1125630011283	Zn binding site [ion binding]; other site
1125630011284	Cytidine and deoxycytidylate deaminase zinc-binding region; Region: dCMP_cyt_deam_2; pfam08211
1125630011285	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
1125630011286	active site
1125630011287	catalytic motif [active]
1125630011288	Zn binding site [ion binding]; other site
1125630011289	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1125630011290	putative active site [active]
1125630011291	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1125630011292	TM-ABC transporter signature motif; other site
1125630011293	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1125630011294	galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982
1125630011295	Walker A/P-loop; other site
1125630011296	ATP binding site [chemical binding]; other site
1125630011297	Q-loop/lid; other site
1125630011298	ABC transporter signature motif; other site
1125630011299	Walker B; other site
1125630011300	D-loop; other site
1125630011301	H-loop/switch region; other site
1125630011302	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1125630011303	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1125630011304	Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539
1125630011305	ligand binding site [chemical binding]; other site
1125630011306	calcium binding site [ion binding]; other site
1125630011307	DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401
1125630011308	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1125630011309	DNA binding site [nucleotide binding]
1125630011310	domain linker motif; other site
1125630011311	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
1125630011312	dimerization interface (closed form) [polypeptide binding]; other site
1125630011313	ligand binding site [chemical binding]; other site
1125630011314	Predicted membrane protein [Function unknown]; Region: COG2311
1125630011315	hypothetical protein; Provisional; Region: PRK10835
1125630011316	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
1125630011317	active site
1125630011318	Predicted esterase [General function prediction only]; Region: COG0627
1125630011319	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187
1125630011320	potential frameshift: common BLAST hit: gi|152971132|ref|YP_001336241.1| colicin I receptor
1125630011321	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1125630011322	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1125630011323	N-terminal plug; other site
1125630011324	ligand-binding site [chemical binding]; other site
1125630011325	lysine transporter; Provisional; Region: PRK10836
1125630011326	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
1125630011327	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
1125630011328	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630011329	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
1125630011330	putative dimerization interface [polypeptide binding]; other site
1125630011331	conserved hypothetical integral membrane protein; Region: TIGR00698
1125630011332	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
1125630011333	AP (apurinic/apyrimidinic) site pocket; other site
1125630011334	DNA interaction; other site
1125630011335	Metal-binding active site; metal-binding site
1125630011336	PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712
1125630011337	N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925
1125630011338	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1125630011339	active site
1125630011340	P-loop; other site
1125630011341	phosphorylation site [posttranslational modification]
1125630011342	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
1125630011343	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1125630011344	putative substrate binding site [chemical binding]; other site
1125630011345	putative ATP binding site [chemical binding]; other site
1125630011346	bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109
1125630011347	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1125630011348	active site
1125630011349	phosphorylation site [posttranslational modification]
1125630011350	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1125630011351	dimerization domain swap beta strand [polypeptide binding]; other site
1125630011352	regulatory protein interface [polypeptide binding]; other site
1125630011353	active site
1125630011354	regulatory phosphorylation site [posttranslational modification]; other site
1125630011355	sugar efflux transporter B; Provisional; Region: PRK15011
1125630011356	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630011357	putative substrate translocation pore; other site
1125630011358	GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440
1125630011359	putative active site [active]
1125630011360	putative metal binding site [ion binding]; other site
1125630011361	elongation factor P; Provisional; Region: PRK04542
1125630011362	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1125630011363	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1125630011364	RNA binding site [nucleotide binding]; other site
1125630011365	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1125630011366	RNA binding site [nucleotide binding]; other site
1125630011367	mannonate dehydratase; Provisional; Region: PRK03906
1125630011368	mannonate dehydratase; Region: uxuA; TIGR00695
1125630011369	D-mannonate oxidoreductase; Provisional; Region: PRK15037
1125630011370	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1125630011371	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1125630011372	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1125630011373	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1125630011374	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1125630011375	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1125630011376	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
1125630011377	active site
1125630011378	NlpC/P60 family; Region: NLPC_P60; pfam00877
1125630011379	phage resistance protein; Provisional; Region: PRK10551
1125630011380	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
1125630011381	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1125630011382	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1125630011383	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
1125630011384	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
1125630011385	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630011386	dimer interface [polypeptide binding]; other site
1125630011387	conserved gate region; other site
1125630011388	putative PBP binding loops; other site
1125630011389	ABC-ATPase subunit interface; other site
1125630011390	microcin C ABC transporter permease; Provisional; Region: PRK15021
1125630011391	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630011392	dimer interface [polypeptide binding]; other site
1125630011393	conserved gate region; other site
1125630011394	putative PBP binding loops; other site
1125630011395	ABC-ATPase subunit interface; other site
1125630011396	microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134
1125630011397	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1125630011398	Walker A/P-loop; other site
1125630011399	ATP binding site [chemical binding]; other site
1125630011400	Q-loop/lid; other site
1125630011401	ABC transporter signature motif; other site
1125630011402	Walker B; other site
1125630011403	D-loop; other site
1125630011404	H-loop/switch region; other site
1125630011405	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1125630011406	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1125630011407	Walker A/P-loop; other site
1125630011408	ATP binding site [chemical binding]; other site
1125630011409	Q-loop/lid; other site
1125630011410	ABC transporter signature motif; other site
1125630011411	Walker B; other site
1125630011412	D-loop; other site
1125630011413	H-loop/switch region; other site
1125630011414	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1125630011415	hypothetical protein; Provisional; Region: PRK11835
1125630011416	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630011417	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
1125630011418	putative substrate translocation pore; other site
1125630011419	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
1125630011420	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1125630011421	RNA binding surface [nucleotide binding]; other site
1125630011422	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
1125630011423	active site
1125630011424	uracil binding [chemical binding]; other site
1125630011425	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1125630011426	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1125630011427	ATP binding site [chemical binding]; other site
1125630011428	putative Mg++ binding site [ion binding]; other site
1125630011429	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1125630011430	nucleotide binding region [chemical binding]; other site
1125630011431	ATP-binding site [chemical binding]; other site
1125630011432	Ribosomal L40e family; Region: Ribosomal_L40e; cl00671
1125630011433	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
1125630011434	5S rRNA interface [nucleotide binding]; other site
1125630011435	CTC domain interface [polypeptide binding]; other site
1125630011436	L16 interface [polypeptide binding]; other site
1125630011437	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630011438	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630011439	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1125630011440	dimerization interface [polypeptide binding]; other site
1125630011441	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1125630011442	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
1125630011443	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1125630011444	dimer interface [polypeptide binding]; other site
1125630011445	ADP-ribose binding site [chemical binding]; other site
1125630011446	active site
1125630011447	nudix motif; other site
1125630011448	metal binding site [ion binding]; metal-binding site
1125630011449	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1125630011450	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
1125630011451	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1125630011452	nucleoid-associated protein NdpA; Validated; Region: PRK00378
1125630011453	hypothetical protein; Provisional; Region: PRK13689
1125630011454	Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083
1125630011455	Domain of unknown function (DUF3413); Region: DUF3413; pfam11893
1125630011456	Sulfatase; Region: Sulfatase; cl19157
1125630011457	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1125630011458	Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242
1125630011459	secondary substrate binding site; other site
1125630011460	primary substrate binding site; other site
1125630011461	inhibition loop; other site
1125630011462	dimerization interface [polypeptide binding]; other site
1125630011463	malate:quinone oxidoreductase; Validated; Region: PRK05257
1125630011464	Predicted dehydrogenase [General function prediction only]; Region: COG0579
1125630011465	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1125630011466	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1125630011467	Sulfate transporter family; Region: Sulfate_transp; cl19250
1125630011468	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
1125630011469	MgtE intracellular N domain; Region: MgtE_N; smart00924
1125630011470	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
1125630011471	Divalent cation transporter; Region: MgtE; cl00786
1125630011472	multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522
1125630011473	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1125630011474	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1125630011475	Walker A/P-loop; other site
1125630011476	ATP binding site [chemical binding]; other site
1125630011477	Q-loop/lid; other site
1125630011478	ABC transporter signature motif; other site
1125630011479	Walker B; other site
1125630011480	D-loop; other site
1125630011481	H-loop/switch region; other site
1125630011482	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
1125630011483	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
1125630011484	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
1125630011485	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630011486	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630011487	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
1125630011488	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1125630011489	DNA binding site [nucleotide binding]
1125630011490	active site
1125630011491	thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461
1125630011492	outer membrane porin protein C; Provisional; Region: PRK10554
1125630011493	phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618
1125630011494	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1125630011495	ATP binding site [chemical binding]; other site
1125630011496	Mg2+ binding site [ion binding]; other site
1125630011497	G-X-G motif; other site
1125630011498	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1125630011499	putative binding surface; other site
1125630011500	active site
1125630011501	transcriptional regulator RcsB; Provisional; Region: PRK10840
1125630011502	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1125630011503	active site
1125630011504	phosphorylation site [posttranslational modification]
1125630011505	intermolecular recognition site; other site
1125630011506	dimerization interface [polypeptide binding]; other site
1125630011507	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1125630011508	DNA binding residues [nucleotide binding]
1125630011509	dimerization interface [polypeptide binding]; other site
1125630011510	hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841
1125630011511	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1125630011512	dimer interface [polypeptide binding]; other site
1125630011513	phosphorylation site [posttranslational modification]
1125630011514	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1125630011515	ATP binding site [chemical binding]; other site
1125630011516	Mg2+ binding site [ion binding]; other site
1125630011517	G-X-G motif; other site
1125630011518	RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456
1125630011519	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1125630011520	active site
1125630011521	phosphorylation site [posttranslational modification]
1125630011522	intermolecular recognition site; other site
1125630011523	dimerization interface [polypeptide binding]; other site
1125630011524	DNA gyrase subunit A; Validated; Region: PRK05560
1125630011525	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1125630011526	CAP-like domain; other site
1125630011527	active site
1125630011528	primary dimer interface [polypeptide binding]; other site
1125630011529	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1125630011530	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1125630011531	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1125630011532	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1125630011533	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1125630011534	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1125630011535	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
1125630011536	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1125630011537	S-adenosylmethionine binding site [chemical binding]; other site
1125630011538	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103
1125630011539	ATP cone domain; Region: ATP-cone; pfam03477
1125630011540	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
1125630011541	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1125630011542	dimer interface [polypeptide binding]; other site
1125630011543	putative radical transfer pathway; other site
1125630011544	diiron center [ion binding]; other site
1125630011545	tyrosyl radical; other site
1125630011546	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1125630011547	catalytic loop [active]
1125630011548	iron binding site [ion binding]; other site
1125630011549	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
1125630011550	Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600
1125630011551	active site
1125630011552	catalytic site [active]
1125630011553	metal binding site [ion binding]; metal-binding site
1125630011554	sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273
1125630011555	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630011556	putative substrate translocation pore; other site
1125630011557	sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101
1125630011558	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1125630011559	anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329
1125630011560	FAD binding domain; Region: FAD_binding_2; pfam00890
1125630011561	glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379
1125630011562	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
1125630011563	Cysteine-rich domain; Region: CCG; pfam02754
1125630011564	Cysteine-rich domain; Region: CCG; pfam02754
1125630011565	2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128
1125630011566	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
1125630011567	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630011568	putative substrate translocation pore; other site
1125630011569	L-rhamnonate dehydratase; Provisional; Region: PRK15440
1125630011570	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327
1125630011571	putative active site pocket [active]
1125630011572	putative metal binding site [ion binding]; other site
1125630011573	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1125630011574	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1125630011575	Bacterial transcriptional regulator; Region: IclR; pfam01614
1125630011576	hypothetical protein; Provisional; Region: PRK03673
1125630011577	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
1125630011578	putative MPT binding site; other site
1125630011579	Competence-damaged protein; Region: CinA; cl00666
1125630011580	YfaZ precursor; Region: YfaZ; pfam07437
1125630011581	hypothetical protein; Provisional; Region: PRK09956
1125630011582	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
1125630011583	Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811
1125630011584	nucleoside triphosphatase NudI; Provisional; Region: PRK15472
1125630011585	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029
1125630011586	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
1125630011587	acyl-activating enzyme (AAE) consensus motif; other site
1125630011588	putative AMP binding site [chemical binding]; other site
1125630011589	putative active site [active]
1125630011590	putative CoA binding site [chemical binding]; other site
1125630011591	O-succinylbenzoate synthase; Provisional; Region: PRK05105
1125630011592	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
1125630011593	active site
1125630011594	dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396
1125630011595	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1125630011596	substrate binding site [chemical binding]; other site
1125630011597	oxyanion hole (OAH) forming residues; other site
1125630011598	trimer interface [polypeptide binding]; other site
1125630011599	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126
1125630011600	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
1125630011601	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
1125630011602	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
1125630011603	dimer interface [polypeptide binding]; other site
1125630011604	tetramer interface [polypeptide binding]; other site
1125630011605	PYR/PP interface [polypeptide binding]; other site
1125630011606	TPP binding site [chemical binding]; other site
1125630011607	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
1125630011608	TPP-binding site; other site
1125630011609	menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012
1125630011610	chorismate binding enzyme; Region: Chorismate_bind; cl10555
1125630011611	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1125630011612	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1125630011613	Coenzyme A binding pocket [chemical binding]; other site
1125630011614	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1125630011615	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
1125630011616	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1125630011617	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
1125630011618	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1125630011619	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
1125630011620	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
1125630011621	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1125630011622	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
1125630011623	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
1125630011624	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
1125630011625	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
1125630011626	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
1125630011627	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
1125630011628	NADH dehydrogenase subunit G; Validated; Region: PRK08166
1125630011629	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
1125630011630	MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771
1125630011631	[4Fe-4S] binding site [ion binding]; other site
1125630011632	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
1125630011633	NADH dehydrogenase I subunit F; Provisional; Region: PRK11278
1125630011634	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
1125630011635	SLBB domain; Region: SLBB; pfam10531
1125630011636	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
1125630011637	NADH:ubiquinone oxidoreductase 24 kD subunit [Energy production and conversion]; Region: NuoE; COG1905
1125630011638	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
1125630011639	putative dimer interface [polypeptide binding]; other site
1125630011640	[2Fe-2S] cluster binding site [ion binding]; other site
1125630011641	NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852
1125630011642	bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742
1125630011643	Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl19174
1125630011644	NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377
1125630011645	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
1125630011646	DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092
1125630011647	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630011648	The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439
1125630011649	putative dimerization interface [polypeptide binding]; other site
1125630011650	aminotransferase AlaT; Validated; Region: PRK09265
1125630011651	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1125630011652	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630011653	homodimer interface [polypeptide binding]; other site
1125630011654	catalytic residue [active]
1125630011655	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1125630011656	Zn2+ binding site [ion binding]; other site
1125630011657	Mg2+ binding site [ion binding]; other site
1125630011658	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
1125630011659	transmembrane helices; other site
1125630011660	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1125630011661	TrkA-C domain; Region: TrkA_C; pfam02080
1125630011662	TrkA-C domain; Region: TrkA_C; pfam02080
1125630011663	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1125630011664	putative phosphatase; Provisional; Region: PRK11587
1125630011665	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1125630011666	active site
1125630011667	motif I; other site
1125630011668	motif II; other site
1125630011669	hypothetical protein; Validated; Region: PRK05445
1125630011670	hypothetical protein; Provisional; Region: PRK01816
1125630011671	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1125630011672	phosphate acetyltransferase; Reviewed; Region: PRK05632
1125630011673	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1125630011674	DRTGG domain; Region: DRTGG; pfam07085
1125630011675	phosphate acetyltransferase; Region: pta; TIGR00651
1125630011676	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697
1125630011677	nudix motif; other site
1125630011678	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
1125630011679	active site
1125630011680	metal binding site [ion binding]; metal-binding site
1125630011681	homotetramer interface [polypeptide binding]; other site
1125630011682	glutathione S-transferase; Provisional; Region: PRK15113
1125630011683	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
1125630011684	C-terminal domain interface [polypeptide binding]; other site
1125630011685	GSH binding site (G-site) [chemical binding]; other site
1125630011686	dimer interface [polypeptide binding]; other site
1125630011687	C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195
1125630011688	N-terminal domain interface [polypeptide binding]; other site
1125630011689	putative dimer interface [polypeptide binding]; other site
1125630011690	putative substrate binding pocket (H-site) [chemical binding]; other site
1125630011691	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
1125630011692	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
1125630011693	C-terminal domain interface [polypeptide binding]; other site
1125630011694	GSH binding site (G-site) [chemical binding]; other site
1125630011695	dimer interface [polypeptide binding]; other site
1125630011696	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
1125630011697	N-terminal domain interface [polypeptide binding]; other site
1125630011698	putative dimer interface [polypeptide binding]; other site
1125630011699	active site
1125630011700	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
1125630011701	homooctamer interface [polypeptide binding]; other site
1125630011702	active site
1125630011703	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
1125630011704	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
1125630011705	putative NAD(P) binding site [chemical binding]; other site
1125630011706	putative active site [active]
1125630011707	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1125630011708	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1125630011709	Coenzyme A binding pocket [chemical binding]; other site
1125630011710	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1125630011711	histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619
1125630011712	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1125630011713	Walker A/P-loop; other site
1125630011714	ATP binding site [chemical binding]; other site
1125630011715	Q-loop/lid; other site
1125630011716	ABC transporter signature motif; other site
1125630011717	Walker B; other site
1125630011718	D-loop; other site
1125630011719	H-loop/switch region; other site
1125630011720	ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism]; Region: ArtM; COG4160
1125630011721	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630011722	dimer interface [polypeptide binding]; other site
1125630011723	conserved gate region; other site
1125630011724	putative PBP binding loops; other site
1125630011725	ABC-ATPase subunit interface; other site
1125630011726	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1125630011727	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630011728	dimer interface [polypeptide binding]; other site
1125630011729	conserved gate region; other site
1125630011730	putative PBP binding loops; other site
1125630011731	ABC-ATPase subunit interface; other site
1125630011732	histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437
1125630011733	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1125630011734	substrate binding pocket [chemical binding]; other site
1125630011735	membrane-bound complex binding site; other site
1125630011736	hinge residues; other site
1125630011737	ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010
1125630011738	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1125630011739	substrate binding pocket [chemical binding]; other site
1125630011740	membrane-bound complex binding site; other site
1125630011741	hinge residues; other site
1125630011742	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
1125630011743	amidophosphoribosyltransferase; Provisional; Region: PRK09246
1125630011744	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1125630011745	active site
1125630011746	tetramer interface [polypeptide binding]; other site
1125630011747	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1125630011748	active site
1125630011749	colicin V production protein; Provisional; Region: PRK10845
1125630011750	cell division protein DedD; Provisional; Region: PRK11633
1125630011751	Modulator of retrovirus infection; Region: MRI; pfam15325
1125630011752	Sporulation related domain; Region: SPOR; pfam05036
1125630011753	bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846
1125630011754	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1125630011755	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1125630011756	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
1125630011757	hypothetical protein; Provisional; Region: PRK10847
1125630011758	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1125630011759	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1125630011760	dimerization interface 3.5A [polypeptide binding]; other site
1125630011761	active site
1125630011762	putative semialdehyde dehydrogenase; Provisional; Region: PRK08040
1125630011763	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118
1125630011764	Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774
1125630011765	erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438
1125630011766	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
1125630011767	ligand binding site [chemical binding]; other site
1125630011768	NAD binding site [chemical binding]; other site
1125630011769	catalytic site [active]
1125630011770	homodimer interface [polypeptide binding]; other site
1125630011771	flagella biosynthesis regulator; Provisional; Region: flk; PRK10715
1125630011772	putative transporter; Provisional; Region: PRK12382
1125630011773	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630011774	putative substrate translocation pore; other site
1125630011775	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
1125630011776	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1125630011777	dimer interface [polypeptide binding]; other site
1125630011778	active site
1125630011779	Uncharacterized conserved protein [Function unknown]; Region: COG4121
1125630011780	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
1125630011781	tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197
1125630011782	YfcL protein; Region: YfcL; pfam08891
1125630011783	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101
1125630011784	hypothetical protein; Provisional; Region: PRK10621
1125630011785	Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770
1125630011786	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
1125630011787	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1125630011788	Tetramer interface [polypeptide binding]; other site
1125630011789	active site
1125630011790	FMN-binding site [chemical binding]; other site
1125630011791	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK11805
1125630011792	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1125630011793	S-adenosylmethionine binding site [chemical binding]; other site
1125630011794	hypothetical protein; Provisional; Region: PRK04946
1125630011795	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
1125630011796	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1125630011797	catalytic core [active]
1125630011798	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
1125630011799	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1125630011800	substrate binding site [chemical binding]; other site
1125630011801	oxyanion hole (OAH) forming residues; other site
1125630011802	trimer interface [polypeptide binding]; other site
1125630011803	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1125630011804	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1125630011805	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1125630011806	3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963
1125630011807	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1125630011808	dimer interface [polypeptide binding]; other site
1125630011809	active site
1125630011810	conserved hypothetical protein; Region: TIGR00743
1125630011811	potential frameshift: common BLAST hit: gi|238895857|ref|YP_002920593.1| long-chain fatty acid outer membrane transporter
1125630011812	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
1125630011813	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
1125630011814	ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091
1125630011815	potential frameshift: common BLAST hit: gi|238895859|ref|YP_002920595.1| putative transport protein
1125630011816	Formate/nitrite transporter; Region: Form_Nir_trans; cl00927
1125630011817	Formate/nitrite transporter; Region: Form_Nir_trans; cl00927
1125630011818	cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366
1125630011819	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
1125630011820	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630011821	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1125630011822	dimerization interface [polypeptide binding]; other site
1125630011823	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1125630011824	nucleoside/Zn binding site; other site
1125630011825	dimer interface [polypeptide binding]; other site
1125630011826	catalytic motif [active]
1125630011827	putative cyanate transporter; Provisional; Region: cynX; PRK09705
1125630011828	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630011829	putative substrate translocation pore; other site
1125630011830	aminotransferase; Validated; Region: PRK08175
1125630011831	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1125630011832	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630011833	homodimer interface [polypeptide binding]; other site
1125630011834	catalytic residue [active]
1125630011835	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
1125630011836	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1125630011837	GAF domain; Region: GAF_2; pfam13185
1125630011838	Histidine kinase; Region: His_kinase; pfam06580
1125630011839	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1125630011840	ATP binding site [chemical binding]; other site
1125630011841	Mg2+ binding site [ion binding]; other site
1125630011842	G-X-G motif; other site
1125630011843	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1125630011844	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1125630011845	active site
1125630011846	phosphorylation site [posttranslational modification]
1125630011847	intermolecular recognition site; other site
1125630011848	dimerization interface [polypeptide binding]; other site
1125630011849	LytTr DNA-binding domain; Region: LytTR; pfam04397
1125630011850	glucokinase; Provisional; Region: glk; PRK00292
1125630011851	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
1125630011852	Cl- selectivity filter; other site
1125630011853	Cl- binding residues [ion binding]; other site
1125630011854	pore gating glutamate residue; other site
1125630011855	dimer interface [polypeptide binding]; other site
1125630011856	indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393
1125630011857	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
1125630011858	dimer interface [polypeptide binding]; other site
1125630011859	PYR/PP interface [polypeptide binding]; other site
1125630011860	TPP binding site [chemical binding]; other site
1125630011861	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1125630011862	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
1125630011863	TPP-binding site [chemical binding]; other site
1125630011864	dimer interface [polypeptide binding]; other site
1125630011865	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
1125630011866	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1125630011867	active site
1125630011868	catalytic tetrad [active]
1125630011869	Protein of unknown function (DUF2502); Region: DUF2502; pfam10697
1125630011870	manganese transport protein MntH; Reviewed; Region: PRK00701
1125630011871	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1125630011872	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1125630011873	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1125630011874	Nucleoside recognition; Region: Gate; pfam07670
1125630011875	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1125630011876	MASE1; Region: MASE1; cl17823
1125630011877	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1125630011878	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
1125630011879	metal binding site [ion binding]; metal-binding site
1125630011880	nucleotidyl binding site; other site
1125630011881	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1125630011882	Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037
1125630011883	Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037
1125630011884	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1125630011885	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1125630011886	active site
1125630011887	HIGH motif; other site
1125630011888	KMSKS motif; other site
1125630011889	Protein of unknown function (DUF3150); Region: DUF3150; pfam11348
1125630011890	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630011891	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630011892	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
1125630011893	putative dimerization interface [polypeptide binding]; other site
1125630011894	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
1125630011895	Protein of unknown function (DUF3820); Region: DUF3820; pfam12843
1125630011896	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1125630011897	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1125630011898	nucleotide binding pocket [chemical binding]; other site
1125630011899	K-X-D-G motif; other site
1125630011900	catalytic site [active]
1125630011901	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1125630011902	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1125630011903	Helix-hairpin-helix domain; Region: HHH_5; pfam14520
1125630011904	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
1125630011905	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1125630011906	Dimer interface [polypeptide binding]; other site
1125630011907	cell division protein ZipA; Provisional; Region: PRK03427
1125630011908	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231
1125630011909	FtsZ protein binding site [polypeptide binding]; other site
1125630011910	putative sulfate transport protein CysZ; Validated; Region: PRK04949
1125630011911	cysteine synthase; Region: PLN02565
1125630011912	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1125630011913	dimer interface [polypeptide binding]; other site
1125630011914	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630011915	catalytic residue [active]
1125630011916	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1125630011917	dimerization domain swap beta strand [polypeptide binding]; other site
1125630011918	regulatory protein interface [polypeptide binding]; other site
1125630011919	active site
1125630011920	regulatory phosphorylation site [posttranslational modification]; other site
1125630011921	phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177
1125630011922	PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524
1125630011923	PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1125630011924	PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1125630011925	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
1125630011926	HPr interaction site; other site
1125630011927	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1125630011928	active site
1125630011929	phosphorylation site [posttranslational modification]
1125630011930	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
1125630011931	dimer interface [polypeptide binding]; other site
1125630011932	pyridoxal binding site [chemical binding]; other site
1125630011933	ATP binding site [chemical binding]; other site
1125630011934	transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481
1125630011935	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1125630011936	DNA-binding site [nucleotide binding]; DNA binding site
1125630011937	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1125630011938	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630011939	homodimer interface [polypeptide binding]; other site
1125630011940	catalytic residue [active]
1125630011941	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
1125630011942	cysteine synthase; Region: PLN02565
1125630011943	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1125630011944	dimer interface [polypeptide binding]; other site
1125630011945	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630011946	catalytic residue [active]
1125630011947	sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851
1125630011948	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
1125630011949	Walker A/P-loop; other site
1125630011950	ATP binding site [chemical binding]; other site
1125630011951	Q-loop/lid; other site
1125630011952	ABC transporter signature motif; other site
1125630011953	Walker B; other site
1125630011954	D-loop; other site
1125630011955	H-loop/switch region; other site
1125630011956	TOBE-like domain; Region: TOBE_3; pfam12857
1125630011957	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1125630011958	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630011959	dimer interface [polypeptide binding]; other site
1125630011960	conserved gate region; other site
1125630011961	putative PBP binding loops; other site
1125630011962	ABC-ATPase subunit interface; other site
1125630011963	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1125630011964	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630011965	dimer interface [polypeptide binding]; other site
1125630011966	conserved gate region; other site
1125630011967	putative PBP binding loops; other site
1125630011968	ABC-ATPase subunit interface; other site
1125630011969	thiosulfate transporter subunit; Provisional; Region: PRK10852
1125630011970	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
1125630011971	RpoE-regulated lipoprotein; Provisional; Region: PRK10718
1125630011972	Protein of unknown function (DUF2919); Region: DUF2919; pfam11143
1125630011973	putative acetyltransferase; Provisional; Region: PRK03624
1125630011974	Uncharacterized conserved protein [Function unknown]; Region: COG3375
1125630011975	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1125630011976	Coenzyme A binding pocket [chemical binding]; other site
1125630011977	N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319
1125630011978	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1125630011979	active site
1125630011980	metal binding site [ion binding]; metal-binding site
1125630011981	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
1125630011982	transcriptional regulator EutR; Provisional; Region: PRK10130
1125630011983	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630011984	carboxysome structural protein EutK; Provisional; Region: PRK15466
1125630011985	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
1125630011986	Hexamer interface [polypeptide binding]; other site
1125630011987	Hexagonal pore residue; other site
1125630011988	ethanolamine utilization protein EutL; Provisional; Region: PRK15405
1125630011989	Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982
1125630011990	Hexamer interface [polypeptide binding]; other site
1125630011991	Hexagonal pore residue; other site
1125630011992	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050
1125630011993	putative hexamer interface [polypeptide binding]; other site
1125630011994	putative hexagonal pore; other site
1125630011995	Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302
1125630011996	Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303
1125630011997	reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719
1125630011998	Ppx/GppA phosphatase family; Region: Ppx-GppA; cl19483
1125630011999	Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192
1125630012000	iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551
1125630012001	active site
1125630012002	metal binding site [ion binding]; metal-binding site
1125630012003	Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820
1125630012004	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1125630012005	nucleotide binding site [chemical binding]; other site
1125630012006	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1125630012007	nucleotide binding site [chemical binding]; other site
1125630012008	Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121
1125630012009	putative catalytic cysteine [active]
1125630012010	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
1125630012011	Hexamer/Pentamer interface [polypeptide binding]; other site
1125630012012	central pore; other site
1125630012013	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
1125630012014	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
1125630012015	Hexamer interface [polypeptide binding]; other site
1125630012016	Hexagonal pore residue; other site
1125630012017	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
1125630012018	ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020
1125630012019	ethanolamine utilization protein EutQ; Provisional; Region: PRK15457
1125630012020	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
1125630012021	G1 box; other site
1125630012022	GTP/Mg2+ binding site [chemical binding]; other site
1125630012023	G2 box; other site
1125630012024	Switch I region; other site
1125630012025	G3 box; other site
1125630012026	Switch II region; other site
1125630012027	G4 box; other site
1125630012028	G5 box; other site
1125630012029	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
1125630012030	putative hexamer interface [polypeptide binding]; other site
1125630012031	putative hexagonal pore; other site
1125630012032	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
1125630012033	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1125630012034	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
1125630012035	putative NAD(P) binding site [chemical binding]; other site
1125630012036	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
1125630012037	transaldolase-like protein; Provisional; Region: PTZ00411
1125630012038	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
1125630012039	active site
1125630012040	dimer interface [polypeptide binding]; other site
1125630012041	catalytic residue [active]
1125630012042	transketolase; Reviewed; Region: PRK12753
1125630012043	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1125630012044	TPP-binding site [chemical binding]; other site
1125630012045	dimer interface [polypeptide binding]; other site
1125630012046	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1125630012047	PYR/PP interface [polypeptide binding]; other site
1125630012048	dimer interface [polypeptide binding]; other site
1125630012049	TPP binding site [chemical binding]; other site
1125630012050	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1125630012051	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
1125630012052	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
1125630012053	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
1125630012054	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1125630012055	dimer interface [polypeptide binding]; other site
1125630012056	ADP-ribose binding site [chemical binding]; other site
1125630012057	active site
1125630012058	nudix motif; other site
1125630012059	metal binding site [ion binding]; metal-binding site
1125630012060	putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769
1125630012061	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
1125630012062	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691
1125630012063	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1125630012064	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1125630012065	aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555
1125630012066	MMPL family; Region: MMPL; cl14618
1125630012067	MMPL family; Region: MMPL; cl14618
1125630012068	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
1125630012069	putative catalytic residues [active]
1125630012070	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
1125630012071	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
1125630012072	metal binding site [ion binding]; metal-binding site
1125630012073	dimer interface [polypeptide binding]; other site
1125630012074	hypothetical protein; Provisional; Region: PRK13664
1125630012075	putative hydrolase; Provisional; Region: PRK11460
1125630012076	Predicted esterase [General function prediction only]; Region: COG0400
1125630012077	potential frameshift: common BLAST hit: gi|238895934|ref|YP_002920670.1| putative acyl-CoA N-acyltransferase
1125630012078	Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444
1125630012079	GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718
1125630012080	Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725
1125630012081	Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444
1125630012082	Domain of unknown function (DUF1726); Region: DUF1726; pfam08351
1125630012083	Helicase; Region: Helicase_RecD; pfam05127
1125630012084	GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718
1125630012085	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
1125630012086	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
1125630012087	ATP binding site [chemical binding]; other site
1125630012088	active site
1125630012089	substrate binding site [chemical binding]; other site
1125630012090	lipoprotein; Provisional; Region: PRK11679
1125630012091	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1125630012092	dimer interface [polypeptide binding]; other site
1125630012093	active site
1125630012094	catalytic residue [active]
1125630012095	glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589
1125630012096	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893
1125630012097	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1125630012098	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1125630012099	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1125630012100	catalytic triad [active]
1125630012101	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1125630012102	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
1125630012103	Peptidase family M48; Region: Peptidase_M48; cl12018
1125630012104	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
1125630012105	catalytic residues [active]
1125630012106	hypothetical protein; Provisional; Region: PRK09956
1125630012107	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
1125630012108	DNA replication initiation factor; Provisional; Region: PRK08084
1125630012109	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
1125630012110	uracil transporter; Provisional; Region: PRK10720
1125630012111	uracil-xanthine permease; Region: ncs2; TIGR00801
1125630012112	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1125630012113	active site
1125630012114	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046
1125630012115	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1125630012116	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1125630012117	nucleotide binding site [chemical binding]; other site
1125630012118	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
1125630012119	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1125630012120	dimerization interface [polypeptide binding]; other site
1125630012121	putative ATP binding site [chemical binding]; other site
1125630012122	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1125630012123	active site
1125630012124	substrate binding site [chemical binding]; other site
1125630012125	cosubstrate binding site; other site
1125630012126	catalytic site [active]
1125630012127	Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855
1125630012128	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
1125630012129	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
1125630012130	Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164
1125630012131	domain interface [polypeptide binding]; other site
1125630012132	active site
1125630012133	catalytic site [active]
1125630012134	Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167
1125630012135	domain interface [polypeptide binding]; other site
1125630012136	active site
1125630012137	catalytic site [active]
1125630012138	exopolyphosphatase; Provisional; Region: PRK10854
1125630012139	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1125630012140	MASE1; Region: MASE1; cl17823
1125630012141	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
1125630012142	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1125630012143	Protein of unknown function (DUF2633); Region: DUF2633; pfam11119
1125630012144	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630012145	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630012146	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1125630012147	dimerization interface [polypeptide binding]; other site
1125630012148	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1125630012149	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630012150	putative substrate translocation pore; other site
1125630012151	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
1125630012152	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
1125630012153	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
1125630012154	Sulfatase; Region: Sulfatase; cl19157
1125630012155	GMP synthase; Reviewed; Region: guaA; PRK00074
1125630012156	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1125630012157	AMP/PPi binding site [chemical binding]; other site
1125630012158	candidate oxyanion hole; other site
1125630012159	catalytic triad [active]
1125630012160	potential glutamine specificity residues [chemical binding]; other site
1125630012161	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1125630012162	ATP Binding subdomain [chemical binding]; other site
1125630012163	Ligand Binding sites [chemical binding]; other site
1125630012164	Dimerization subdomain; other site
1125630012165	potential frameshift: common BLAST hit: gi|238895962|ref|YP_002920698.1| inosine 5'-monophosphate dehydrogenase
1125630012166	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1125630012167	phosphate binding site [ion binding]; other site
1125630012168	IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516
1125630012169	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1125630012170	FOG: CBS domain [General function prediction only]; Region: COG0517
1125630012171	Domain in cystathionine beta-synthase and other proteins; Region: CBS; smart00116
1125630012172	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
1125630012173	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1125630012174	generic binding surface II; other site
1125630012175	generic binding surface I; other site
1125630012176	zinc-ribbons; Region: zinc-ribbons_6; pfam07191
1125630012177	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1125630012178	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; cl19130
1125630012179	GTP-binding protein Der; Reviewed; Region: PRK00093
1125630012180	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1125630012181	G1 box; other site
1125630012182	GTP/Mg2+ binding site [chemical binding]; other site
1125630012183	Switch I region; other site
1125630012184	G2 box; other site
1125630012185	Switch II region; other site
1125630012186	G3 box; other site
1125630012187	G4 box; other site
1125630012188	G5 box; other site
1125630012189	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1125630012190	G1 box; other site
1125630012191	GTP/Mg2+ binding site [chemical binding]; other site
1125630012192	Switch I region; other site
1125630012193	G2 box; other site
1125630012194	G3 box; other site
1125630012195	Switch II region; other site
1125630012196	G4 box; other site
1125630012197	G5 box; other site
1125630012198	KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714
1125630012199	outer membrane biogenesis protein BamB; Provisional; Region: PRK11138
1125630012200	Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276
1125630012201	Trp docking motif [polypeptide binding]; other site
1125630012202	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
1125630012203	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649
1125630012204	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
1125630012205	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1125630012206	dimer interface [polypeptide binding]; other site
1125630012207	motif 1; other site
1125630012208	active site
1125630012209	motif 2; other site
1125630012210	motif 3; other site
1125630012211	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1125630012212	anticodon binding site; other site
1125630012213	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
1125630012214	1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612
1125630012215	cytoskeletal protein RodZ; Provisional; Region: PRK10856
1125630012216	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1125630012217	non-specific DNA binding site [nucleotide binding]; other site
1125630012218	salt bridge; other site
1125630012219	sequence-specific DNA binding site [nucleotide binding]; other site
1125630012220	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
1125630012221	23S rRNA m2A2503 methyltransferase; Region: TIGR00048
1125630012222	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1125630012223	FeS/SAM binding site; other site
1125630012224	Nucleoside diphosphate kinase; Region: NDK; pfam00334
1125630012225	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1125630012226	active site
1125630012227	multimer interface [polypeptide binding]; other site
1125630012228	penicillin-binding protein 1C; Provisional; Region: PRK11240
1125630012229	Transglycosylase; Region: Transgly; pfam00912
1125630012230	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1125630012231	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
1125630012232	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
1125630012233	MG2 domain; Region: A2M_N; pfam01835
1125630012234	Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703
1125630012235	Alpha-2-macroglobulin family; Region: A2M; pfam00207
1125630012236	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
1125630012237	surface patch; other site
1125630012238	thioester region; other site
1125630012239	specificity defining residues; other site
1125630012240	3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493
1125630012241	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
1125630012242	active site residue [active]
1125630012243	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1125630012244	active site residue [active]
1125630012245	SseB protein N-terminal domain; Region: SseB; pfam07179
1125630012246	enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611
1125630012247	SseB protein C-terminal domain; Region: SseB_C; pfam14581
1125630012248	aminopeptidase B; Provisional; Region: PRK05015
1125630012249	Peptidase; Region: DUF3663; pfam12404
1125630012250	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1125630012251	interface (dimer of trimers) [polypeptide binding]; other site
1125630012252	Substrate-binding/catalytic site; other site
1125630012253	Zn-binding sites [ion binding]; other site
1125630012254	hypothetical protein; Provisional; Region: PRK10721
1125630012255	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1125630012256	catalytic loop [active]
1125630012257	iron binding site [ion binding]; other site
1125630012258	chaperone protein HscA; Provisional; Region: hscA; PRK05183
1125630012259	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
1125630012260	nucleotide binding site [chemical binding]; other site
1125630012261	putative NEF/HSP70 interaction site [polypeptide binding]; other site
1125630012262	SBD interface [polypeptide binding]; other site
1125630012263	co-chaperone HscB; Provisional; Region: hscB; PRK05014
1125630012264	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1125630012265	HSP70 interaction site [polypeptide binding]; other site
1125630012266	HSCB C-terminal oligomerization domain; Region: HSCB_C; pfam07743
1125630012267	iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502
1125630012268	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1125630012269	trimerization site [polypeptide binding]; other site
1125630012270	active site
1125630012271	cysteine desulfurase; Provisional; Region: PRK14012
1125630012272	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1125630012273	catalytic residue [active]
1125630012274	DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857
1125630012275	Rrf2 family protein; Region: rrf2_super; TIGR00738
1125630012276	tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114
1125630012277	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
1125630012278	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
1125630012279	active site
1125630012280	dimerization interface [polypeptide binding]; other site
1125630012281	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215
1125630012282	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683
1125630012283	stationary phase inducible protein CsiE; Provisional; Region: PRK11564
1125630012284	PRD domain; Region: PRD; pfam00874
1125630012285	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
1125630012286	aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021
1125630012287	active site
1125630012288	catalytic residues [active]
1125630012289	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
1125630012290	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630012291	putative substrate translocation pore; other site
1125630012292	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
1125630012293	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1125630012294	binding surface
1125630012295	TPR motif; other site
1125630012296	TPR repeat; Region: TPR_11; pfam13414
1125630012297	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1125630012298	binding surface
1125630012299	TPR motif; other site
1125630012300	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1125630012301	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1125630012302	binding surface
1125630012303	TPR motif; other site
1125630012304	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
1125630012305	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1125630012306	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1125630012307	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1125630012308	Predicted membrane protein [Function unknown]; Region: COG2259
1125630012309	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1125630012310	dimer interface [polypeptide binding]; other site
1125630012311	active site
1125630012312	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1125630012313	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
1125630012314	folate binding site [chemical binding]; other site
1125630012315	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
1125630012316	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
1125630012317	heme-binding site [chemical binding]; other site
1125630012318	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
1125630012319	FAD binding pocket [chemical binding]; other site
1125630012320	FAD binding motif [chemical binding]; other site
1125630012321	phosphate binding motif [ion binding]; other site
1125630012322	beta-alpha-beta structure motif; other site
1125630012323	NAD binding pocket [chemical binding]; other site
1125630012324	Heme binding  pocket [chemical binding]; other site
1125630012325	nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858
1125630012326	response regulator GlrR; Provisional; Region: PRK15115
1125630012327	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1125630012328	active site
1125630012329	phosphorylation site [posttranslational modification]
1125630012330	intermolecular recognition site; other site
1125630012331	dimerization interface [polypeptide binding]; other site
1125630012332	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1125630012333	Walker A motif; other site
1125630012334	ATP binding site [chemical binding]; other site
1125630012335	Walker B motif; other site
1125630012336	arginine finger; other site
1125630012337	hypothetical protein; Provisional; Region: PRK10722
1125630012338	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1125630012339	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1125630012340	dimer interface [polypeptide binding]; other site
1125630012341	phosphorylation site [posttranslational modification]
1125630012342	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1125630012343	ATP binding site [chemical binding]; other site
1125630012344	Mg2+ binding site [ion binding]; other site
1125630012345	G-X-G motif; other site
1125630012346	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
1125630012347	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1125630012348	dimerization interface [polypeptide binding]; other site
1125630012349	ATP binding site [chemical binding]; other site
1125630012350	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
1125630012351	dimerization interface [polypeptide binding]; other site
1125630012352	ATP binding site [chemical binding]; other site
1125630012353	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1125630012354	putative active site [active]
1125630012355	catalytic triad [active]
1125630012356	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
1125630012357	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1125630012358	substrate binding pocket [chemical binding]; other site
1125630012359	membrane-bound complex binding site; other site
1125630012360	hinge residues; other site
1125630012361	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1125630012362	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1125630012363	catalytic residue [active]
1125630012364	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1125630012365	nucleoside/Zn binding site; other site
1125630012366	dimer interface [polypeptide binding]; other site
1125630012367	catalytic motif [active]
1125630012368	hypothetical protein; Provisional; Region: PRK11590
1125630012369	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1125630012370	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557
1125630012371	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1125630012372	putative active site [active]
1125630012373	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1125630012374	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
1125630012375	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
1125630012376	active site
1125630012377	hydrophilic channel; other site
1125630012378	dimerization interface [polypeptide binding]; other site
1125630012379	catalytic residues [active]
1125630012380	active site lid [active]
1125630012381	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
1125630012382	Recombination protein O N terminal; Region: RecO_N; pfam11967
1125630012383	Recombination protein O C terminal; Region: RecO_C; pfam02565
1125630012384	GTPase Era; Reviewed; Region: era; PRK00089
1125630012385	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1125630012386	G1 box; other site
1125630012387	GTP/Mg2+ binding site [chemical binding]; other site
1125630012388	Switch I region; other site
1125630012389	G2 box; other site
1125630012390	Switch II region; other site
1125630012391	G3 box; other site
1125630012392	G4 box; other site
1125630012393	G5 box; other site
1125630012394	KH domain; Region: KH_2; pfam07650
1125630012395	ribonuclease III; Reviewed; Region: rnc; PRK00102
1125630012396	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1125630012397	dimerization interface [polypeptide binding]; other site
1125630012398	active site
1125630012399	metal binding site [ion binding]; metal-binding site
1125630012400	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1125630012401	dsRNA binding site [nucleotide binding]; other site
1125630012402	signal peptidase I; Provisional; Region: PRK10861
1125630012403	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1125630012404	Catalytic site [active]
1125630012405	GTP-binding protein LepA; Provisional; Region: PRK05433
1125630012406	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1125630012407	G1 box; other site
1125630012408	putative GEF interaction site [polypeptide binding]; other site
1125630012409	GTP/Mg2+ binding site [chemical binding]; other site
1125630012410	Switch I region; other site
1125630012411	G2 box; other site
1125630012412	G3 box; other site
1125630012413	Switch II region; other site
1125630012414	G4 box; other site
1125630012415	G5 box; other site
1125630012416	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1125630012417	Elongation Factor G, domain II; Region: EFG_II; pfam14492
1125630012418	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1125630012419	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1125630012420	SoxR reducing system protein RseC; Provisional; Region: PRK10862
1125630012421	anti-sigma E factor; Provisional; Region: rseB; PRK09455
1125630012422	anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863
1125630012423	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
1125630012424	Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873
1125630012425	RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939
1125630012426	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1125630012427	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1125630012428	DNA binding residues [nucleotide binding]
1125630012429	L-aspartate oxidase; Provisional; Region: PRK09077
1125630012430	L-aspartate oxidase; Provisional; Region: PRK06175
1125630012431	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1125630012432	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
1125630012433	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1125630012434	S-adenosylmethionine binding site [chemical binding]; other site
1125630012435	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
1125630012436	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1125630012437	ATP binding site [chemical binding]; other site
1125630012438	Mg++ binding site [ion binding]; other site
1125630012439	motif III; other site
1125630012440	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1125630012441	nucleotide binding region [chemical binding]; other site
1125630012442	ATP-binding site [chemical binding]; other site
1125630012443	autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127
1125630012444	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
1125630012445	ligand binding site [chemical binding]; other site
1125630012446	active site
1125630012447	UGI interface [polypeptide binding]; other site
1125630012448	catalytic site [active]
1125630012449	putative methyltransferase; Provisional; Region: PRK10864
1125630012450	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1125630012451	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1125630012452	thioredoxin 2; Provisional; Region: PRK10996
1125630012453	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1125630012454	catalytic residues [active]
1125630012455	Uncharacterized conserved protein [Function unknown]; Region: COG3148
1125630012456	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
1125630012457	CoA binding domain; Region: CoA_binding_2; pfam13380
1125630012458	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
1125630012459	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
1125630012460	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1125630012461	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1125630012462	phosphatidylserine synthase; Provisional; Region: pssA; PRK09428
1125630012463	Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134
1125630012464	domain interface [polypeptide binding]; other site
1125630012465	putative active site [active]
1125630012466	catalytic site [active]
1125630012467	Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136
1125630012468	domain interface [polypeptide binding]; other site
1125630012469	putative active site [active]
1125630012470	catalytic site [active]
1125630012471	lipoprotein; Provisional; Region: PRK10759
1125630012472	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
1125630012473	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630012474	putative substrate translocation pore; other site
1125630012475	protein disaggregation chaperone; Provisional; Region: PRK10865
1125630012476	Clp amino terminal domain; Region: Clp_N; pfam02861
1125630012477	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1125630012478	Walker A motif; other site
1125630012479	ATP binding site [chemical binding]; other site
1125630012480	Walker B motif; other site
1125630012481	arginine finger; other site
1125630012482	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1125630012483	Walker A motif; other site
1125630012484	ATP binding site [chemical binding]; other site
1125630012485	Walker B motif; other site
1125630012486	arginine finger; other site
1125630012487	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1125630012488	hypothetical protein; Provisional; Region: PRK10723
1125630012489	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
1125630012490	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1125630012491	RNA binding surface [nucleotide binding]; other site
1125630012492	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1125630012493	active site
1125630012494	outer membrane biogenesis protein BamD; Provisional; Region: PRK10866
1125630012495	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1125630012496	30S subunit binding site; other site
1125630012497	bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622
1125630012498	chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797
1125630012499	Prephenate dehydratase; Region: PDT; pfam00800
1125630012500	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
1125630012501	putative L-Phe binding site [chemical binding]; other site
1125630012502	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
1125630012503	bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199
1125630012504	Chorismate mutase type II; Region: CM_2; cl00693
1125630012505	prephenate dehydrogenase; Validated; Region: PRK08507
1125630012506	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
1125630012507	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
1125630012508	putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966
1125630012509	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1125630012510	metal binding site [ion binding]; metal-binding site
1125630012511	active site
1125630012512	I-site; other site
1125630012513	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1125630012514	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1125630012515	ligand binding site [chemical binding]; other site
1125630012516	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
1125630012517	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
1125630012518	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
1125630012519	Ribosomal S4P (gammaproteobacterial); Region: Ribosomal_S4Pg; pfam11993
1125630012520	Protein of unknown function (DUF2946); Region: DUF2946; pfam11162
1125630012521	integrase; Provisional; Region: int; PHA02601
1125630012522	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1125630012523	active site
1125630012524	DNA binding site [nucleotide binding]
1125630012525	Int/Topo IB signature motif; other site
1125630012526	Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022
1125630012527	Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892
1125630012528	Protein of unknown function (DUF2724); Region: DUF2724; pfam10893
1125630012529	Protein of unknown function (DUF2732); Region: DUF2732; pfam10809
1125630012530	DksA-like zinc finger domain containing protein; Region: PHA00080
1125630012531	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
1125630012532	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1125630012533	active site
1125630012534	catalytic site [active]
1125630012535	substrate binding site [chemical binding]; other site
1125630012536	Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840
1125630012537	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1125630012538	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1125630012539	putative active site [active]
1125630012540	putative NTP binding site [chemical binding]; other site
1125630012541	putative nucleic acid binding site [nucleotide binding]; other site
1125630012542	DinI-like family; Region: DinI; cl11630
1125630012543	portal vertex protein; Provisional; Region: Q; PHA02536
1125630012544	terminase ATPase subunit; Provisional; Region: P; PHA02535
1125630012545	Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056
1125630012546	Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; pfam05929
1125630012547	potential frameshift: common BLAST hit: gi|152973344|ref|YP_001337124.1| putative prophage major capsid protein
1125630012548	Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947
1125630012549	Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947
1125630012550	terminase endonuclease subunit; Provisional; Region: M; PHA02537
1125630012551	Phage head completion protein (GPL); Region: Phage_GPL; pfam05926
1125630012552	Phage Tail Protein X; Region: Phage_tail_X; pfam05489
1125630012553	Phage holin family 2; Region: Phage_holin_2; pfam04550
1125630012554	The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes.  But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736
1125630012555	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1125630012556	catalytic residue [active]
1125630012557	phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495
1125630012558	P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891
1125630012559	Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069
1125630012560	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
1125630012561	baseplate wedge subunit; Provisional; Region: W; PHA02516
1125630012562	baseplate assembly protein; Provisional; Region: J; PHA02568
1125630012563	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684
1125630012564	6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase; Provisional; Region: PTZ00322
1125630012565	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
1125630012566	major tail sheath protein; Provisional; Region: FI; PHA02560
1125630012567	Phage tail tube protein FII; Region: Phage_tube; cl01390
1125630012568	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
1125630012569	Phage P2 GpE; Region: Phage_P2_GpE; pfam06528
1125630012570	Phage-related tail protein [Function unknown]; Region: COG5283
1125630012571	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
1125630012572	Phage P2 GpU; Region: Phage_P2_GpU; cl01391
1125630012573	tail protein; Provisional; Region: D; PHA02561
1125630012574	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1125630012575	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1125630012576	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1125630012577	RimM N-terminal domain; Region: RimM; pfam01782
1125630012578	PRC-barrel domain; Region: PRC; pfam05239
1125630012579	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
1125630012580	signal recognition particle protein; Provisional; Region: PRK10867
1125630012581	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1125630012582	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1125630012583	P loop; other site
1125630012584	GTP binding site [chemical binding]; other site
1125630012585	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1125630012586	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137
1125630012587	Domain of unknown function DUF21; Region: DUF21; pfam01595
1125630012588	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
1125630012589	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1125630012590	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1125630012591	Transporter associated domain; Region: CorC_HlyC; smart01091
1125630012592	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1125630012593	dimer interface [polypeptide binding]; other site
1125630012594	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1125630012595	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378
1125630012596	recombination and repair protein; Provisional; Region: PRK10869
1125630012597	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1125630012598	Walker A/P-loop; other site
1125630012599	ATP binding site [chemical binding]; other site
1125630012600	Q-loop/lid; other site
1125630012601	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1125630012602	ABC transporter signature motif; other site
1125630012603	Walker B; other site
1125630012604	D-loop; other site
1125630012605	H-loop/switch region; other site
1125630012606	outer membrane biogenesis protein BamE; Provisional; Region: PRK11548
1125630012607	hypothetical protein; Validated; Region: PRK01777
1125630012608	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
1125630012609	putative coenzyme Q binding site [chemical binding]; other site
1125630012610	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1125630012611	SmpB-tmRNA interface; other site
1125630012612	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1125630012613	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
1125630012614	GAF domain; Region: GAF; pfam01590
1125630012615	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1125630012616	Walker A motif; other site
1125630012617	ATP binding site [chemical binding]; other site
1125630012618	Walker B motif; other site
1125630012619	arginine finger; other site
1125630012620	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1125630012621	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630012622	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630012623	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475
1125630012624	putative effector binding pocket; other site
1125630012625	putative dimerization interface [polypeptide binding]; other site
1125630012626	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
1125630012627	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1125630012628	dimerization interface [polypeptide binding]; other site
1125630012629	putative DNA binding site [nucleotide binding]; other site
1125630012630	putative Zn2+ binding site [ion binding]; other site
1125630012631	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1125630012632	active site residue [active]
1125630012633	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
1125630012634	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
1125630012635	Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293
1125630012636	Domain in histone-like proteins of HNS family; Region: HNS; cl19571
1125630012637	DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328
1125630012638	Protein of unknown function (DUF1144); Region: DUF1144; pfam06610
1125630012639	hypothetical protein; Provisional; Region: PRK10556
1125630012640	hypothetical protein; Provisional; Region: PRK10132
1125630012641	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1125630012642	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1125630012643	DNA-binding site [nucleotide binding]; DNA binding site
1125630012644	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1125630012645	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630012646	homodimer interface [polypeptide binding]; other site
1125630012647	catalytic residue [active]
1125630012648	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1125630012649	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1125630012650	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
1125630012651	catalytic residues [active]
1125630012652	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
1125630012653	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
1125630012654	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
1125630012655	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1125630012656	active site
1125630012657	dimer interface [polypeptide binding]; other site
1125630012658	catalytic residues [active]
1125630012659	effector binding site; other site
1125630012660	R2 peptide binding site; other site
1125630012661	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1125630012662	dimer interface [polypeptide binding]; other site
1125630012663	putative radical transfer pathway; other site
1125630012664	diiron center [ion binding]; other site
1125630012665	tyrosyl radical; other site
1125630012666	glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070
1125630012667	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
1125630012668	Walker A/P-loop; other site
1125630012669	ATP binding site [chemical binding]; other site
1125630012670	Q-loop/lid; other site
1125630012671	ABC transporter signature motif; other site
1125630012672	Walker B; other site
1125630012673	D-loop; other site
1125630012674	H-loop/switch region; other site
1125630012675	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
1125630012676	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1125630012677	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630012678	dimer interface [polypeptide binding]; other site
1125630012679	conserved gate region; other site
1125630012680	putative PBP binding loops; other site
1125630012681	ABC-ATPase subunit interface; other site
1125630012682	glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119
1125630012683	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
1125630012684	putative L-valine exporter; Provisional; Region: PRK10408
1125630012685	transcriptional repressor MprA; Provisional; Region: PRK10870
1125630012686	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1125630012687	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
1125630012688	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1125630012689	HlyD family secretion protein; Region: HlyD_3; pfam13437
1125630012690	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1125630012691	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630012692	putative substrate translocation pore; other site
1125630012693	2-isopropylmalate synthase; Validated; Region: PRK03739
1125630012694	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
1125630012695	active site
1125630012696	catalytic residues [active]
1125630012697	metal binding site [ion binding]; metal-binding site
1125630012698	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
1125630012699	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1125630012700	Helix-turn-helix domain; Region: HTH_18; pfam12833
1125630012701	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630012702	S-ribosylhomocysteinase; Provisional; Region: PRK02260
1125630012703	glutamate--cysteine ligase; Provisional; Region: PRK02107
1125630012704	Predicted membrane protein [Function unknown]; Region: COG1238
1125630012705	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
1125630012706	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1125630012707	active site
1125630012708	motif I; other site
1125630012709	motif II; other site
1125630012710	BON domain; Region: BON; pfam04972
1125630012711	Global regulator protein family; Region: CsrA; cl00670
1125630012712	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1125630012713	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1125630012714	motif 1; other site
1125630012715	active site
1125630012716	motif 2; other site
1125630012717	motif 3; other site
1125630012718	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1125630012719	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
1125630012720	DHHA1 domain; Region: DHHA1; pfam02272
1125630012721	recombination regulator RecX; Reviewed; Region: recX; PRK00117
1125630012722	recombinase A; Provisional; Region: recA; PRK09354
1125630012723	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1125630012724	hexamer interface [polypeptide binding]; other site
1125630012725	Walker A motif; other site
1125630012726	ATP binding site [chemical binding]; other site
1125630012727	Walker B motif; other site
1125630012728	hypothetical protein; Validated; Region: PRK03661
1125630012729	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
1125630012730	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
1125630012731	metal binding site [ion binding]; metal-binding site
1125630012732	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1125630012733	ABC-ATPase subunit  interface; other site
1125630012734	dimer interface [polypeptide binding]; other site
1125630012735	putative PBP binding regions; other site
1125630012736	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1125630012737	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1125630012738	Walker A/P-loop; other site
1125630012739	ATP binding site [chemical binding]; other site
1125630012740	Q-loop/lid; other site
1125630012741	ABC transporter signature motif; other site
1125630012742	Walker B; other site
1125630012743	D-loop; other site
1125630012744	H-loop/switch region; other site
1125630012745	murein hydrolase B; Provisional; Region: PRK10760
1125630012746	lytic murein transglycosylase B; Region: MltB; TIGR02282
1125630012747	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1125630012748	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1125630012749	catalytic residue [active]
1125630012750	PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821
1125630012751	Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732
1125630012752	Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612
1125630012753	Nucleoside recognition; Region: Gate; pfam07670
1125630012754	Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663
1125630012755	PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377
1125630012756	sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384
1125630012757	Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322
1125630012758	putative NAD(P) binding site [chemical binding]; other site
1125630012759	active site
1125630012760	DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234
1125630012761	DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434
1125630012762	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1125630012763	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1125630012764	D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543
1125630012765	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
1125630012766	putative active site [active]
1125630012767	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
1125630012768	anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022
1125630012769	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1125630012770	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1125630012771	Walker A motif; other site
1125630012772	ATP binding site [chemical binding]; other site
1125630012773	Walker B motif; other site
1125630012774	arginine finger; other site
1125630012775	anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452
1125630012776	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1125630012777	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
1125630012778	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
1125630012779	iron binding site [ion binding]; other site
1125630012780	NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965
1125630012781	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1125630012782	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1125630012783	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
1125630012784	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
1125630012785	Acylphosphatase; Region: Acylphosphatase; pfam00708
1125630012786	HypF finger; Region: zf-HYPF; pfam07503
1125630012787	HypF finger; Region: zf-HYPF; pfam07503
1125630012788	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
1125630012789	formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330
1125630012790	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
1125630012791	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1125630012792	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1125630012793	DNA binding site [nucleotide binding]
1125630012794	domain linker motif; other site
1125630012795	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
1125630012796	dimerization interface (closed form) [polypeptide binding]; other site
1125630012797	ligand binding site [chemical binding]; other site
1125630012798	PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796
1125630012799	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1125630012800	active site turn [active]
1125630012801	phosphorylation site [posttranslational modification]
1125630012802	PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852
1125630012803	cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852
1125630012804	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232
1125630012805	Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845
1125630012806	Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067
1125630012807	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
1125630012808	nickel binding site [ion binding]; other site
1125630012809	formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084
1125630012810	Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260
1125630012811	formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387
1125630012812	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
1125630012813	Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262
1125630012814	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
1125630012815	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
1125630012816	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
1125630012817	formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042
1125630012818	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1125630012819	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
1125630012820	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
1125630012821	Transcriptional repressor of hyc and hyp operons; Region: HycA_repressor; pfam11046
1125630012822	hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681
1125630012823	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1125630012824	hydrogenase assembly chaperone; Provisional; Region: PRK10409
1125630012825	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
1125630012826	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
1125630012827	dimerization interface [polypeptide binding]; other site
1125630012828	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
1125630012829	ATP binding site [chemical binding]; other site
1125630012830	formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429
1125630012831	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1125630012832	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1125630012833	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1125630012834	Walker A motif; other site
1125630012835	ATP binding site [chemical binding]; other site
1125630012836	Walker B motif; other site
1125630012837	arginine finger; other site
1125630012838	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
1125630012839	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232
1125630012840	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
1125630012841	Sugar-binding cellulase-like; Region: Cellulase-like; cl19200
1125630012842	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1125630012843	Interdomain contacts; other site
1125630012844	Cytokine receptor motif; other site
1125630012845	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
1125630012846	putative metal binding site [ion binding]; other site
1125630012847	maltoporin; Provisional; Region: lamB; PRK09360
1125630012848	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1125630012849	potential frameshift: common BLAST hit: gi|238896192|ref|YP_002920928.1| PEP-dependent phosphotransferase enzyme II
1125630012850	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1125630012851	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1125630012852	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
1125630012853	active site
1125630012854	P-loop; other site
1125630012855	phosphorylation site [posttranslational modification]
1125630012856	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1125630012857	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
1125630012858	methionine cluster; other site
1125630012859	active site
1125630012860	phosphorylation site [posttranslational modification]
1125630012861	metal binding site [ion binding]; metal-binding site
1125630012862	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1125630012863	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1125630012864	nucleotide binding site [chemical binding]; other site
1125630012865	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1125630012866	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1125630012867	DNA binding site [nucleotide binding]
1125630012868	domain linker motif; other site
1125630012869	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1125630012870	ligand binding site [chemical binding]; other site
1125630012871	dimerization interface [polypeptide binding]; other site
1125630012872	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
1125630012873	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
1125630012874	metal binding site [ion binding]; metal-binding site
1125630012875	manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056
1125630012876	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1125630012877	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1125630012878	ABC-ATPase subunit  interface; other site
1125630012879	dimer interface [polypeptide binding]; other site
1125630012880	putative PBP binding regions; other site
1125630012881	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1125630012882	ABC-ATPase subunit  interface; other site
1125630012883	dimer interface [polypeptide binding]; other site
1125630012884	putative PBP binding regions; other site
1125630012885	Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756
1125630012886	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630012887	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630012888	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1125630012889	dimerization interface [polypeptide binding]; other site
1125630012890	Membrane transport protein; Region: Mem_trans; cl09117
1125630012891	acetolactate synthase catalytic subunit; Validated; Region: PRK08327
1125630012892	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1125630012893	PYR/PP interface [polypeptide binding]; other site
1125630012894	dimer interface [polypeptide binding]; other site
1125630012895	TPP binding site [chemical binding]; other site
1125630012896	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1125630012897	TPP-binding site [chemical binding]; other site
1125630012898	Rdx family; Region: Rdx; cl01407
1125630012899	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
1125630012900	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1125630012901	N-terminal plug; other site
1125630012902	ligand-binding site [chemical binding]; other site
1125630012903	Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720
1125630012904	Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171
1125630012905	Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171
1125630012906	Hemin binding protein HutB.  These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149
1125630012907	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1125630012908	putative hemin binding site; other site
1125630012909	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1125630012910	ABC-ATPase subunit  interface; other site
1125630012911	dimer interface [polypeptide binding]; other site
1125630012912	putative PBP binding regions; other site
1125630012913	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
1125630012914	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1125630012915	Walker A/P-loop; other site
1125630012916	ATP binding site [chemical binding]; other site
1125630012917	Q-loop/lid; other site
1125630012918	ABC transporter signature motif; other site
1125630012919	Walker B; other site
1125630012920	D-loop; other site
1125630012921	H-loop/switch region; other site
1125630012922	type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344
1125630012923	Protein of unknown function (DUF1493); Region: DUF1493; pfam07377
1125630012924	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
1125630012925	MutS domain I; Region: MutS_I; pfam01624
1125630012926	MutS domain II; Region: MutS_II; pfam05188
1125630012927	MutS domain III; Region: MutS_III; pfam05192
1125630012928	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
1125630012929	Walker A/P-loop; other site
1125630012930	ATP binding site [chemical binding]; other site
1125630012931	Q-loop/lid; other site
1125630012932	ABC transporter signature motif; other site
1125630012933	Walker B; other site
1125630012934	D-loop; other site
1125630012935	H-loop/switch region; other site
1125630012936	Hok/gef family; Region: HOK_GEF; pfam01848
1125630012937	Protein of unknown function (DUF1062); Region: DUF1062; cl01786
1125630012938	3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043
1125630012939	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
1125630012940	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1125630012941	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1125630012942	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630012943	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630012944	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1125630012945	putative effector binding pocket; other site
1125630012946	dimerization interface [polypeptide binding]; other site
1125630012947	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630012948	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1125630012949	putative substrate translocation pore; other site
1125630012950	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460
1125630012951	RNA polymerase sigma factor RpoS; Validated; Region: PRK05657
1125630012952	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1125630012953	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1125630012954	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1125630012955	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1125630012956	DNA binding residues [nucleotide binding]
1125630012957	lipoprotein NlpD; Provisional; Region: nlpD; PRK10871
1125630012958	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1125630012959	Peptidase family M23; Region: Peptidase_M23; pfam01551
1125630012960	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1125630012961	S-adenosylmethionine binding site [chemical binding]; other site
1125630012962	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
1125630012963	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
1125630012964	Permutation of conserved domain; other site
1125630012965	active site
1125630012966	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
1125630012967	homotrimer interaction site [polypeptide binding]; other site
1125630012968	zinc binding site [ion binding]; other site
1125630012969	CDP-binding sites; other site
1125630012970	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1125630012971	substrate binding site; other site
1125630012972	dimer interface; other site
1125630012973	cell division protein FtsB; Reviewed; Region: ftsB; PRK00888
1125630012974	Protein of unknown function (DUF3561); Region: DUF3561; pfam12084
1125630012975	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
1125630012976	ligand-binding site [chemical binding]; other site
1125630012977	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
1125630012978	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
1125630012979	CysD dimerization site [polypeptide binding]; other site
1125630012980	G1 box; other site
1125630012981	putative GEF interaction site [polypeptide binding]; other site
1125630012982	GTP/Mg2+ binding site [chemical binding]; other site
1125630012983	Switch I region; other site
1125630012984	G2 box; other site
1125630012985	G3 box; other site
1125630012986	Switch II region; other site
1125630012987	G4 box; other site
1125630012988	G5 box; other site
1125630012989	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
1125630012990	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
1125630012991	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
1125630012992	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1125630012993	Active Sites [active]
1125630012994	siroheme synthase; Provisional; Region: cysG; PRK10637
1125630012995	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
1125630012996	Sirohaem biosynthesis protein central; Region: Sirohm_synth_M; pfam14824
1125630012997	Sirohaem synthase dimerization region; Region: CysG_dimeriser; pfam10414
1125630012998	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1125630012999	active site
1125630013000	SAM binding site [chemical binding]; other site
1125630013001	homodimer interface [polypeptide binding]; other site
1125630013002	alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199
1125630013003	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
1125630013004	metal binding site [ion binding]; metal-binding site
1125630013005	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
1125630013006	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1125630013007	Active Sites [active]
1125630013008	sulfite reductase subunit beta; Provisional; Region: PRK13504
1125630013009	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1125630013010	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
1125630013011	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1125630013012	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
1125630013013	sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953
1125630013014	Flavodoxin; Region: Flavodoxin_1; pfam00258
1125630013015	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
1125630013016	FAD binding pocket [chemical binding]; other site
1125630013017	FAD binding motif [chemical binding]; other site
1125630013018	catalytic residues [active]
1125630013019	NAD binding pocket [chemical binding]; other site
1125630013020	phosphate binding motif [ion binding]; other site
1125630013021	beta-alpha-beta structure motif; other site
1125630013022	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
1125630013023	active site
1125630013024	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
1125630013025	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
1125630013026	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1125630013027	Male sterility protein; Region: NAD_binding_4; pfam07993
1125630013028	NAD(P) binding site [chemical binding]; other site
1125630013029	active site
1125630013030	enolase; Provisional; Region: eno; PRK00077
1125630013031	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1125630013032	dimer interface [polypeptide binding]; other site
1125630013033	metal binding site [ion binding]; metal-binding site
1125630013034	substrate binding pocket [chemical binding]; other site
1125630013035	CTP synthetase; Validated; Region: pyrG; PRK05380
1125630013036	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1125630013037	Catalytic site [active]
1125630013038	active site
1125630013039	UTP binding site [chemical binding]; other site
1125630013040	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1125630013041	active site
1125630013042	putative oxyanion hole; other site
1125630013043	catalytic triad [active]
1125630013044	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
1125630013045	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
1125630013046	homodimer interface [polypeptide binding]; other site
1125630013047	metal binding site [ion binding]; metal-binding site
1125630013048	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
1125630013049	homodimer interface [polypeptide binding]; other site
1125630013050	active site
1125630013051	putative chemical substrate binding site [chemical binding]; other site
1125630013052	metal binding site [ion binding]; metal-binding site
1125630013053	(p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872
1125630013054	HD domain; Region: HD_4; pfam13328
1125630013055	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1125630013056	synthetase active site [active]
1125630013057	NTP binding site [chemical binding]; other site
1125630013058	metal binding site [ion binding]; metal-binding site
1125630013059	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1125630013060	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1125630013061	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
1125630013062	TRAM domain; Region: TRAM; pfam01938
1125630013063	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1125630013064	S-adenosylmethionine binding site [chemical binding]; other site
1125630013065	hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107
1125630013066	Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984
1125630013067	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1125630013068	dimerization interface [polypeptide binding]; other site
1125630013069	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1125630013070	dimer interface [polypeptide binding]; other site
1125630013071	phosphorylation site [posttranslational modification]
1125630013072	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1125630013073	ATP binding site [chemical binding]; other site
1125630013074	Mg2+ binding site [ion binding]; other site
1125630013075	G-X-G motif; other site
1125630013076	Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999
1125630013077	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1125630013078	active site
1125630013079	phosphorylation site [posttranslational modification]
1125630013080	intermolecular recognition site; other site
1125630013081	dimerization interface [polypeptide binding]; other site
1125630013082	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1125630013083	putative binding surface; other site
1125630013084	active site
1125630013085	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
1125630013086	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
1125630013087	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
1125630013088	active site
1125630013089	tetramer interface [polypeptide binding]; other site
1125630013090	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
1125630013091	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
1125630013092	active site
1125630013093	tetramer interface [polypeptide binding]; other site
1125630013094	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630013095	D-galactonate transporter; Region: 2A0114; TIGR00893
1125630013096	putative substrate translocation pore; other site
1125630013097	flavodoxin; Provisional; Region: PRK08105
1125630013098	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1125630013099	tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563
1125630013100	probable active site [active]
1125630013101	tRNA pseudouridine synthase C; Region: DUF446; cl01187
1125630013102	SecY interacting protein Syd; Provisional; Region: PRK04968
1125630013103	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
1125630013104	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
1125630013105	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
1125630013106	Domain of unknown function (DUF4478); Region: DUF4478; pfam14793
1125630013107	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
1125630013108	Domain of unknown function (DUF3412); Region: DUF3412; pfam11892
1125630013109	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
1125630013110	serine transporter; Region: stp; TIGR00814
1125630013111	L-serine dehydratase TdcG; Provisional; Region: PRK15040
1125630013112	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1125630013113	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
1125630013114	NMT1-like family; Region: NMT1_2; cl17432
1125630013115	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1125630013116	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1125630013117	substrate binding pocket [chemical binding]; other site
1125630013118	membrane-bound complex binding site; other site
1125630013119	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
1125630013120	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1125630013121	active site
1125630013122	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630013123	putative substrate translocation pore; other site
1125630013124	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
1125630013125	NLPA lipoprotein; Region: Lipoprotein_9; cl19159
1125630013126	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630013127	dimer interface [polypeptide binding]; other site
1125630013128	conserved gate region; other site
1125630013129	putative PBP binding loops; other site
1125630013130	ABC-ATPase subunit interface; other site
1125630013131	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
1125630013132	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1125630013133	Walker A/P-loop; other site
1125630013134	ATP binding site [chemical binding]; other site
1125630013135	Q-loop/lid; other site
1125630013136	ABC transporter signature motif; other site
1125630013137	Walker B; other site
1125630013138	D-loop; other site
1125630013139	H-loop/switch region; other site
1125630013140	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1125630013141	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
1125630013142	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
1125630013143	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
1125630013144	active site
1125630013145	dimer interface [polypeptide binding]; other site
1125630013146	non-prolyl cis peptide bond; other site
1125630013147	insertion regions; other site
1125630013148	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
1125630013149	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1125630013150	Walker A motif; other site
1125630013151	ATP binding site [chemical binding]; other site
1125630013152	Walker B motif; other site
1125630013153	arginine finger; other site
1125630013154	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1125630013155	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1125630013156	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1125630013157	substrate binding pocket [chemical binding]; other site
1125630013158	membrane-bound complex binding site; other site
1125630013159	hinge residues; other site
1125630013160	flap endonuclease-like protein; Provisional; Region: PRK09482
1125630013161	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1125630013162	active site
1125630013163	metal binding site 1 [ion binding]; metal-binding site
1125630013164	putative 5' ssDNA interaction site; other site
1125630013165	metal binding site 3; metal-binding site
1125630013166	metal binding site 2 [ion binding]; metal-binding site
1125630013167	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1125630013168	putative DNA binding site [nucleotide binding]; other site
1125630013169	putative metal binding site [ion binding]; other site
1125630013170	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
1125630013171	dimer interface [polypeptide binding]; other site
1125630013172	active site
1125630013173	metal binding site [ion binding]; metal-binding site
1125630013174	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
1125630013175	intersubunit interface [polypeptide binding]; other site
1125630013176	active site
1125630013177	Zn2+ binding site [ion binding]; other site
1125630013178	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
1125630013179	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630013180	putative substrate translocation pore; other site
1125630013181	L-fucose isomerase; Provisional; Region: fucI; PRK10991
1125630013182	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
1125630013183	hexamer (dimer of trimers) interface [polypeptide binding]; other site
1125630013184	trimer interface [polypeptide binding]; other site
1125630013185	substrate binding site [chemical binding]; other site
1125630013186	Mn binding site [ion binding]; other site
1125630013187	L-fuculokinase; Provisional; Region: PRK10331
1125630013188	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1125630013189	nucleotide binding site [chemical binding]; other site
1125630013190	L-fucose mutarotase; Provisional; Region: fucU; PRK15420
1125630013191	DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411
1125630013192	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1125630013193	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1125630013194	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
1125630013195	FtsJ-like methyltransferase; Region: FtsJ; cl17430
1125630013196	hypothetical protein; Provisional; Region: PRK10873
1125630013197	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630013198	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
1125630013199	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1125630013200	dimerization interface [polypeptide binding]; other site
1125630013201	substrate binding pocket [chemical binding]; other site
1125630013202	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
1125630013203	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1125630013204	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1125630013205	catalytic residue [active]
1125630013206	Fe-S metabolizm associated domain; Region: SufE; cl00951
1125630013207	sulfur acceptor protein CsdL; Provisional; Region: PRK15116
1125630013208	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
1125630013209	putative ATP binding site [chemical binding]; other site
1125630013210	putative substrate interface [chemical binding]; other site
1125630013211	murein transglycosylase A; Provisional; Region: mltA; PRK11162
1125630013212	MltA specific insert domain; Region: MltA; smart00925
1125630013213	3D domain; Region: 3D; pfam06725
1125630013214	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
1125630013215	putative dimer interface [polypeptide binding]; other site
1125630013216	active site pocket [active]
1125630013217	putative cataytic base [active]
1125630013218	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
1125630013219	homotrimer interface [polypeptide binding]; other site
1125630013220	Walker A motif; other site
1125630013221	GTP binding site [chemical binding]; other site
1125630013222	Walker B motif; other site
1125630013223	cobyric acid synthase; Provisional; Region: PRK00784
1125630013224	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1125630013225	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
1125630013226	catalytic triad [active]
1125630013227	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638
1125630013228	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1125630013229	Walker A/P-loop; other site
1125630013230	ATP binding site [chemical binding]; other site
1125630013231	Q-loop/lid; other site
1125630013232	ABC transporter signature motif; other site
1125630013233	Walker B; other site
1125630013234	D-loop; other site
1125630013235	H-loop/switch region; other site
1125630013236	cobalt transport protein CbiQ; Provisional; Region: PRK15485
1125630013237	cobalt transport protein CbiN; Provisional; Region: PRK02898
1125630013238	cobalt transport protein CbiM; Validated; Region: PRK08319
1125630013239	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
1125630013240	active site
1125630013241	SAM binding site [chemical binding]; other site
1125630013242	homodimer interface [polypeptide binding]; other site
1125630013243	Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822
1125630013244	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412
1125630013245	active site
1125630013246	C-terminal domain interface [polypeptide binding]; other site
1125630013247	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413
1125630013248	active site
1125630013249	N-terminal domain interface [polypeptide binding]; other site
1125630013250	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
1125630013251	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
1125630013252	active site
1125630013253	SAM binding site [chemical binding]; other site
1125630013254	homodimer interface [polypeptide binding]; other site
1125630013255	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
1125630013256	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
1125630013257	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
1125630013258	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
1125630013259	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
1125630013260	active site
1125630013261	SAM binding site [chemical binding]; other site
1125630013262	homodimer interface [polypeptide binding]; other site
1125630013263	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1125630013264	S-adenosylmethionine binding site [chemical binding]; other site
1125630013265	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
1125630013266	active site
1125630013267	putative homodimer interface [polypeptide binding]; other site
1125630013268	SAM binding site [chemical binding]; other site
1125630013269	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
1125630013270	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286
1125630013271	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
1125630013272	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
1125630013273	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1125630013274	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
1125630013275	catalytic triad [active]
1125630013276	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
1125630013277	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1125630013278	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
1125630013279	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
1125630013280	Hexamer interface [polypeptide binding]; other site
1125630013281	Hexagonal pore residue; other site
1125630013282	propanediol utilization protein PduB; Provisional; Region: PRK15415
1125630013283	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047
1125630013284	putative hexamer interface [polypeptide binding]; other site
1125630013285	putative hexagonal pore; other site
1125630013286	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048
1125630013287	putative hexamer interface [polypeptide binding]; other site
1125630013288	putative hexagonal pore; other site
1125630013289	Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687
1125630013290	alpha-alpha subunit/dimer interface [polypeptide binding]; other site
1125630013291	alpha-beta subunit interface [polypeptide binding]; other site
1125630013292	alpha-gamma subunit interface [polypeptide binding]; other site
1125630013293	active site
1125630013294	substrate and K+ binding site; other site
1125630013295	K+ binding site [ion binding]; other site
1125630013296	cobalamin binding site [chemical binding]; other site
1125630013297	propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042
1125630013298	Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910
1125630013299	Cell division protein FtsA; Region: FtsA; cl17206
1125630013300	Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841
1125630013301	Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288
1125630013302	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
1125630013303	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
1125630013304	Hexamer interface [polypeptide binding]; other site
1125630013305	Hexagonal pore residue; other site
1125630013306	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
1125630013307	Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982
1125630013308	Hexamer interface [polypeptide binding]; other site
1125630013309	Hexagonal pore residue; other site
1125630013310	propanediol utilization phosphotransacylase; Provisional; Region: PRK15070
1125630013311	Propanediol utilisation protein PduL; Region: PduL; pfam06130
1125630013312	Propanediol utilisation protein PduL; Region: PduL; pfam06130
1125630013313	putative propanediol utilization protein PduM; Provisional; Region: PRK15428
1125630013314	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
1125630013315	Hexamer/Pentamer interface [polypeptide binding]; other site
1125630013316	central pore; other site
1125630013317	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
1125630013318	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
1125630013319	Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121
1125630013320	putative catalytic cysteine [active]
1125630013321	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
1125630013322	active site
1125630013323	NAD binding site [chemical binding]; other site
1125630013324	metal binding site [ion binding]; metal-binding site
1125630013325	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
1125630013326	SLBB domain; Region: SLBB; pfam10531
1125630013327	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
1125630013328	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1125630013329	RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375
1125630013330	PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526
1125630013331	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053
1125630013332	putative hexamer interface [polypeptide binding]; other site
1125630013333	putative hexagonal pore; other site
1125630013334	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
1125630013335	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054
1125630013336	putative hexamer interface [polypeptide binding]; other site
1125630013337	putative hexagonal pore; other site
1125630013338	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
1125630013339	putative hexamer interface [polypeptide binding]; other site
1125630013340	putative hexagonal pore; other site
1125630013341	Ethanolamine utilisation - propanediol utilisation; Region: PduV-EutP; pfam10662
1125630013342	G3 box; other site
1125630013343	Switch II region; other site
1125630013344	GTP/Mg2+ binding site [chemical binding]; other site
1125630013345	G4 box; other site
1125630013346	G5 box; other site
1125630013347	propionate kinase; Reviewed; Region: PRK12397
1125630013348	Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542
1125630013349	threonine-phosphate decarboxylase; Provisional; Region: PRK08056
1125630013350	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1125630013351	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630013352	homodimer interface [polypeptide binding]; other site
1125630013353	catalytic residue [active]
1125630013354	AMIN domain; Region: AMIN; pfam11741
1125630013355	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1125630013356	active site
1125630013357	metal binding site [ion binding]; metal-binding site
1125630013358	N-acetylglutamate synthase; Validated; Region: PRK05279
1125630013359	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
1125630013360	putative feedback inhibition sensing region; other site
1125630013361	putative nucleotide binding site [chemical binding]; other site
1125630013362	putative substrate binding site [chemical binding]; other site
1125630013363	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1125630013364	Coenzyme A binding pocket [chemical binding]; other site
1125630013365	exonuclease V subunit alpha; Provisional; Region: recD; PRK10875
1125630013366	AAA domain; Region: AAA_30; pfam13604
1125630013367	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
1125630013368	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
1125630013369	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1125630013370	protease3; Provisional; Region: PRK15101
1125630013371	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1125630013372	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1125630013373	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1125630013374	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
1125630013375	Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330
1125630013376	hypothetical protein; Provisional; Region: PRK10332
1125630013377	hypothetical protein; Provisional; Region: PRK11521
1125630013378	hypothetical protein; Provisional; Region: PRK10557
1125630013379	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
1125630013380	hypothetical protein; Provisional; Region: PRK10506
1125630013381	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1125630013382	dimerization interface [polypeptide binding]; other site
1125630013383	active site
1125630013384	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
1125630013385	fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061
1125630013386	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1125630013387	PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524
1125630013388	PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1125630013389	PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1125630013390	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
1125630013391	putative active site [active]
1125630013392	Ap4A binding site [chemical binding]; other site
1125630013393	nudix motif; other site
1125630013394	putative metal binding site [ion binding]; other site
1125630013395	MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex.   MutH...; Region: MutH_Sau3AI; cd00583
1125630013396	putative DNA-binding cleft [nucleotide binding]; other site
1125630013397	putative DNA clevage site; other site
1125630013398	molecular lever; other site
1125630013399	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
1125630013400	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
1125630013401	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1125630013402	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
1125630013403	active site
1125630013404	catalytic tetrad [active]
1125630013405	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630013406	putative substrate translocation pore; other site
1125630013407	bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043
1125630013408	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1125630013409	putative acyl-acceptor binding pocket; other site
1125630013410	C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909
1125630013411	acyl-activating enzyme (AAE) consensus motif; other site
1125630013412	putative AMP binding site [chemical binding]; other site
1125630013413	DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727
1125630013414	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1125630013415	DNA binding site [nucleotide binding]
1125630013416	domain linker motif; other site
1125630013417	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
1125630013418	dimerization interface (closed form) [polypeptide binding]; other site
1125630013419	ligand binding site [chemical binding]; other site
1125630013420	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1125630013421	Coenzyme A binding pocket [chemical binding]; other site
1125630013422	DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225
1125630013423	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1125630013424	DNA-binding site [nucleotide binding]; DNA binding site
1125630013425	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1125630013426	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
1125630013427	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232
1125630013428	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1125630013429	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1125630013430	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1125630013431	DNA binding site [nucleotide binding]
1125630013432	domain linker motif; other site
1125630013433	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
1125630013434	dimerization interface (closed form) [polypeptide binding]; other site
1125630013435	ligand binding site [chemical binding]; other site
1125630013436	diaminopimelate decarboxylase; Provisional; Region: PRK11165
1125630013437	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1125630013438	active site
1125630013439	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1125630013440	substrate binding site [chemical binding]; other site
1125630013441	catalytic residues [active]
1125630013442	dimer interface [polypeptide binding]; other site
1125630013443	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
1125630013444	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630013445	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1125630013446	dimerization interface [polypeptide binding]; other site
1125630013447	putative racemase; Provisional; Region: PRK10200
1125630013448	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
1125630013449	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1125630013450	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630013451	dimer interface [polypeptide binding]; other site
1125630013452	conserved gate region; other site
1125630013453	putative PBP binding loops; other site
1125630013454	ABC-ATPase subunit interface; other site
1125630013455	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1125630013456	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630013457	dimer interface [polypeptide binding]; other site
1125630013458	conserved gate region; other site
1125630013459	putative PBP binding loops; other site
1125630013460	ABC-ATPase subunit interface; other site
1125630013461	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1125630013462	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1125630013463	Walker A/P-loop; other site
1125630013464	ATP binding site [chemical binding]; other site
1125630013465	Q-loop/lid; other site
1125630013466	ABC transporter signature motif; other site
1125630013467	Walker B; other site
1125630013468	D-loop; other site
1125630013469	H-loop/switch region; other site
1125630013470	TOBE domain; Region: TOBE_2; pfam08402
1125630013471	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1125630013472	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1125630013473	Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471
1125630013474	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
1125630013475	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1125630013476	substrate binding [chemical binding]; other site
1125630013477	active site
1125630013478	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1125630013479	galactoside permease; Reviewed; Region: lacY; PRK09528
1125630013480	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630013481	putative substrate translocation pore; other site
1125630013482	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1125630013483	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1125630013484	DNA binding site [nucleotide binding]
1125630013485	domain linker motif; other site
1125630013486	Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288
1125630013487	putative dimerization interface [polypeptide binding]; other site
1125630013488	putative ligand binding site [chemical binding]; other site
1125630013489	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
1125630013490	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630013491	putative substrate translocation pore; other site
1125630013492	2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993
1125630013493	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
1125630013494	NADP binding site [chemical binding]; other site
1125630013495	homodimer interface [polypeptide binding]; other site
1125630013496	active site
1125630013497	Oligogalacturonate lyase; Region: Pectate_lyase22; pfam14583
1125630013498	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1125630013499	Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629
1125630013500	putative acyltransferase; Provisional; Region: PRK05790
1125630013501	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1125630013502	dimer interface [polypeptide binding]; other site
1125630013503	active site
1125630013504	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630013505	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630013506	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1125630013507	dimerization interface [polypeptide binding]; other site
1125630013508	Predicted membrane protein [Function unknown]; Region: COG4125
1125630013509	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
1125630013510	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
1125630013511	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
1125630013512	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
1125630013513	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1125630013514	active site
1125630013515	catalytic tetrad [active]
1125630013516	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1125630013517	DNA binding residues [nucleotide binding]
1125630013518	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1125630013519	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
1125630013520	putative major fimbrial protein SthE; Provisional; Region: PRK15292
1125630013521	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
1125630013522	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
1125630013523	PapC N-terminal domain; Region: PapC_N; pfam13954
1125630013524	Outer membrane usher protein; Region: Usher; pfam00577
1125630013525	PapC C-terminal domain; Region: PapC_C; pfam13953
1125630013526	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
1125630013527	Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345
1125630013528	Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753
1125630013529	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
1125630013530	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
1125630013531	EamA-like transporter family; Region: EamA; pfam00892
1125630013532	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1125630013533	EamA-like transporter family; Region: EamA; pfam00892
1125630013534	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1125630013535	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1125630013536	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215
1125630013537	FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197
1125630013538	Int/Topo IB signature motif; other site
1125630013539	FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197
1125630013540	Int/Topo IB signature motif; other site
1125630013541	Fimbrial protein; Region: Fimbrial; cl01416
1125630013542	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
1125630013543	fimbrial chaperone protein FimC; Provisional; Region: PRK15195
1125630013544	Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345
1125630013545	Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753
1125630013546	outer membrane usher protein; Provisional; Region: PRK15193
1125630013547	PapC N-terminal domain; Region: PapC_N; pfam13954
1125630013548	Outer membrane usher protein; Region: Usher; pfam00577
1125630013549	PapC C-terminal domain; Region: PapC_C; pfam13953
1125630013550	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
1125630013551	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
1125630013552	Mannose binding  domain of FimH and related proteins; Region: FimH_man-bind; cd10466
1125630013553	mannosyl binding site [chemical binding]; other site
1125630013554	Fimbrial protein; Region: Fimbrial; cl01416
1125630013555	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
1125630013556	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1125630013557	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1125630013558	Coenzyme A binding pocket [chemical binding]; other site
1125630013559	Uncharacterized conserved protein [Function unknown]; Region: COG3592
1125630013560	multidrug resistance protein MdtN; Provisional; Region: PRK10476
1125630013561	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1125630013562	HlyD family secretion protein; Region: HlyD_3; pfam13437
1125630013563	multidrug efflux system protein MdtO; Provisional; Region: PRK11427
1125630013564	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1125630013565	putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915
1125630013566	Outer membrane efflux protein; Region: OEP; pfam02321
1125630013567	Outer membrane efflux protein; Region: OEP; pfam02321
1125630013568	Domain of unknown function (DUF1889); Region: DUF1889; pfam08986
1125630013569	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
1125630013570	POT family; Region: PTR2; cl17359
1125630013571	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630013572	putative substrate translocation pore; other site
1125630013573	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
1125630013574	catalytic residues [active]
1125630013575	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
1125630013576	transmembrane helices; other site
1125630013577	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1125630013578	dimerization interface [polypeptide binding]; other site
1125630013579	putative DNA binding site [nucleotide binding]; other site
1125630013580	putative Zn2+ binding site [ion binding]; other site
1125630013581	YCII-related domain; Region: YCII; cl00999
1125630013582	Protein of unknown function (DUF1349); Region: DUF1349; pfam07081
1125630013583	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630013584	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630013585	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1125630013586	dimerization interface [polypeptide binding]; other site
1125630013587	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
1125630013588	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1125630013589	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
1125630013590	active site
1125630013591	catalytic tetrad [active]
1125630013592	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
1125630013593	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
1125630013594	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630013595	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630013596	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460
1125630013597	putative substrate binding pocket [chemical binding]; other site
1125630013598	putative dimerization interface [polypeptide binding]; other site
1125630013599	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630013600	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1125630013601	putative substrate translocation pore; other site
1125630013602	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1125630013603	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1125630013604	Peptidase family M23; Region: Peptidase_M23; pfam01551
1125630013605	Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443
1125630013606	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
1125630013607	active site
1125630013608	metal binding site [ion binding]; metal-binding site
1125630013609	nudix motif; other site
1125630013610	lysyl-tRNA synthetase; Reviewed; Region: PRK12445
1125630013611	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1125630013612	dimer interface [polypeptide binding]; other site
1125630013613	putative anticodon binding site; other site
1125630013614	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
1125630013615	motif 1; other site
1125630013616	active site
1125630013617	motif 2; other site
1125630013618	motif 3; other site
1125630013619	peptide chain release factor 2; Provisional; Region: PRK08787
1125630013620	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1125630013621	RF-1 domain; Region: RF-1; pfam00472
1125630013622	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
1125630013623	DHH family; Region: DHH; pfam01368
1125630013624	DHHA1 domain; Region: DHHA1; pfam02272
1125630013625	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
1125630013626	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
1125630013627	dimerization domain [polypeptide binding]; other site
1125630013628	dimer interface [polypeptide binding]; other site
1125630013629	catalytic residues [active]
1125630013630	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
1125630013631	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
1125630013632	active site
1125630013633	Int/Topo IB signature motif; other site
1125630013634	flavodoxin FldB; Provisional; Region: PRK12359
1125630013635	Protein of unknown function (DUF1434); Region: DUF1434; pfam07254
1125630013636	hypothetical protein; Provisional; Region: PRK10878
1125630013637	putative global regulator; Reviewed; Region: PRK09559
1125630013638	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
1125630013639	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
1125630013640	hemolysin; Provisional; Region: PRK15087
1125630013641	ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552
1125630013642	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1125630013643	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1125630013644	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1125630013645	putative active site [active]
1125630013646	6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014
1125630013647	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232
1125630013648	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
1125630013649	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1125630013650	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
1125630013651	DsbD alpha interface [polypeptide binding]; other site
1125630013652	catalytic residues [active]
1125630013653	conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283
1125630013654	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
1125630013655	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
1125630013656	catalytic residues [active]
1125630013657	TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011
1125630013658	catalytic residues [active]
1125630013659	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1125630013660	classical (c) SDRs; Region: SDR_c; cd05233
1125630013661	NAD(P) binding site [chemical binding]; other site
1125630013662	active site
1125630013663	glycine dehydrogenase; Provisional; Region: PRK05367
1125630013664	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1125630013665	tetramer interface [polypeptide binding]; other site
1125630013666	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630013667	catalytic residue [active]
1125630013668	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1125630013669	tetramer interface [polypeptide binding]; other site
1125630013670	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630013671	catalytic residue [active]
1125630013672	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1125630013673	lipoyl attachment site [posttranslational modification]; other site
1125630013674	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
1125630013675	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
1125630013676	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1125630013677	oxidoreductase; Provisional; Region: PRK08013
1125630013678	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
1125630013679	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732
1125630013680	2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984
1125630013681	proline aminopeptidase P II; Provisional; Region: PRK10879
1125630013682	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
1125630013683	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
1125630013684	active site
1125630013685	hypothetical protein; Reviewed; Region: PRK01736
1125630013686	5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333
1125630013687	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
1125630013688	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
1125630013689	ligand binding site [chemical binding]; other site
1125630013690	NAD binding site [chemical binding]; other site
1125630013691	tetramer interface [polypeptide binding]; other site
1125630013692	catalytic site [active]
1125630013693	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
1125630013694	L-serine binding site [chemical binding]; other site
1125630013695	ACT domain interface; other site
1125630013696	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
1125630013697	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1125630013698	active site
1125630013699	dimer interface [polypeptide binding]; other site
1125630013700	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
1125630013701	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630013702	The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428
1125630013703	putative dimerization interface [polypeptide binding]; other site
1125630013704	oxidative stress defense protein; Provisional; Region: PRK11087
1125630013705	arginine exporter protein; Provisional; Region: PRK09304
1125630013706	mechanosensitive channel MscS; Provisional; Region: PRK10334
1125630013707	Conserved TM helix; Region: TM_helix; pfam05552
1125630013708	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1125630013709	Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946
1125630013710	active site
1125630013711	intersubunit interface [polypeptide binding]; other site
1125630013712	zinc binding site [ion binding]; other site
1125630013713	Na+ binding site [ion binding]; other site
1125630013714	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
1125630013715	substrate binding site [chemical binding]; other site
1125630013716	hinge regions; other site
1125630013717	ADP binding site [chemical binding]; other site
1125630013718	catalytic site [active]
1125630013719	erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535
1125630013720	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1125630013721	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1125630013722	transketolase; Reviewed; Region: PRK12753
1125630013723	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1125630013724	TPP-binding site [chemical binding]; other site
1125630013725	dimer interface [polypeptide binding]; other site
1125630013726	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1125630013727	PYR/PP interface [polypeptide binding]; other site
1125630013728	dimer interface [polypeptide binding]; other site
1125630013729	TPP binding site [chemical binding]; other site
1125630013730	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1125630013731	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
1125630013732	outer membrane porin, OprD family; Region: OprD; pfam03573
1125630013733	hypothetical protein; Provisional; Region: PRK07064
1125630013734	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1125630013735	PYR/PP interface [polypeptide binding]; other site
1125630013736	dimer interface [polypeptide binding]; other site
1125630013737	TPP binding site [chemical binding]; other site
1125630013738	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1125630013739	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
1125630013740	TPP-binding site [chemical binding]; other site
1125630013741	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
1125630013742	NAD(P) binding site [chemical binding]; other site
1125630013743	catalytic residues [active]
1125630013744	L-aspartate dehydrogenase; Provisional; Region: PRK13303
1125630013745	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1125630013746	Domain of unknown function DUF108; Region: DUF108; pfam01958
1125630013747	short chain dehydrogenase; Provisional; Region: PRK07062
1125630013748	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1125630013749	NAD(P) binding site [chemical binding]; other site
1125630013750	active site
1125630013751	Probable pheophorbidase; Region: PLN02965; cl17657
1125630013752	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1125630013753	Cupin domain; Region: Cupin_2; pfam07883
1125630013754	D-galactonate transporter; Region: 2A0114; TIGR00893
1125630013755	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630013756	putative substrate translocation pore; other site
1125630013757	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
1125630013758	Squalene epoxidase; Region: SE; cl17314
1125630013759	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1125630013760	Reductase C-terminal; Region: Reductase_C; pfam14759
1125630013761	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1125630013762	active site
1125630013763	metal binding site [ion binding]; metal-binding site
1125630013764	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1125630013765	active site
1125630013766	metal binding site [ion binding]; metal-binding site
1125630013767	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1125630013768	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1125630013769	Bacterial transcriptional regulator; Region: IclR; pfam01614
1125630013770	short chain dehydrogenase; Provisional; Region: PRK12939
1125630013771	classical (c) SDRs; Region: SDR_c; cd05233
1125630013772	NAD(P) binding site [chemical binding]; other site
1125630013773	active site
1125630013774	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1125630013775	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
1125630013776	[2Fe-2S] cluster binding site [ion binding]; other site
1125630013777	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1125630013778	hydrophobic ligand binding site; other site
1125630013779	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
1125630013780	[2Fe-2S] cluster binding site [ion binding]; other site
1125630013781	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630013782	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1125630013783	putative substrate translocation pore; other site
1125630013784	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
1125630013785	oligomer interface [polypeptide binding]; other site
1125630013786	putative active site [active]
1125630013787	Mn binding site [ion binding]; other site
1125630013788	Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166
1125630013789	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
1125630013790	dimer interface [polypeptide binding]; other site
1125630013791	active site
1125630013792	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1125630013793	catalytic residues [active]
1125630013794	substrate binding site [chemical binding]; other site
1125630013795	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1125630013796	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1125630013797	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1125630013798	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1125630013799	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
1125630013800	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630013801	putative substrate translocation pore; other site
1125630013802	Bacterial protein of unknown function (DUF899); Region: DUF899; cl17828
1125630013803	hypothetical protein; Provisional; Region: PRK04860
1125630013804	DNA-specific endonuclease I; Provisional; Region: PRK15137
1125630013805	RNA methyltransferase, RsmE family; Region: TIGR00046
1125630013806	glutathione synthetase; Provisional; Region: PRK05246
1125630013807	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
1125630013808	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
1125630013809	hypothetical protein; Validated; Region: PRK00228
1125630013810	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
1125630013811	DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100
1125630013812	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1125630013813	DNA binding residues [nucleotide binding]
1125630013814	dimerization interface [polypeptide binding]; other site
1125630013815	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
1125630013816	Walker A motif; other site
1125630013817	ATP binding site [chemical binding]; other site
1125630013818	Walker B motif; other site
1125630013819	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
1125630013820	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1125630013821	catalytic residue [active]
1125630013822	YGGT family; Region: YGGT; pfam02325
1125630013823	Predicted integral membrane protein [Function unknown]; Region: COG0762
1125630013824	hypothetical protein; Validated; Region: PRK05090
1125630013825	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1125630013826	active site
1125630013827	dimerization interface [polypeptide binding]; other site
1125630013828	HemN family oxidoreductase; Provisional; Region: PRK05660
1125630013829	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1125630013830	FeS/SAM binding site; other site
1125630013831	HemN C-terminal domain; Region: HemN_C; pfam06969
1125630013832	hypothetical protein; Provisional; Region: PRK10626
1125630013833	hypothetical protein; Provisional; Region: PRK11702
1125630013834	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
1125630013835	adenine DNA glycosylase; Provisional; Region: PRK10880
1125630013836	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1125630013837	minor groove reading motif; other site
1125630013838	helix-hairpin-helix signature motif; other site
1125630013839	substrate binding pocket [chemical binding]; other site
1125630013840	active site
1125630013841	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
1125630013842	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
1125630013843	DNA binding and oxoG recognition site [nucleotide binding]
1125630013844	oxidative damage protection protein; Provisional; Region: PRK05408
1125630013845	Domain of unknown function (DUF3393); Region: DUF3393; pfam11873
1125630013846	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1125630013847	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1125630013848	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1125630013849	catalytic residue [active]
1125630013850	nucleoside transporter; Region: 2A0110; TIGR00889
1125630013851	Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825
1125630013852	ornithine decarboxylase; Provisional; Region: PRK13578
1125630013853	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
1125630013854	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
1125630013855	homodimer interface [polypeptide binding]; other site
1125630013856	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630013857	catalytic residue [active]
1125630013858	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
1125630013859	Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811
1125630013860	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1125630013861	active site
1125630013862	catalytic residues [active]
1125630013863	DNA binding site [nucleotide binding]
1125630013864	Int/Topo IB signature motif; other site
1125630013865	integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760
1125630013866	Protein of unknown function (DUF1528); Region: DUF1528; pfam07515
1125630013867	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
1125630013868	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
1125630013869	Protein of unknown function (DUF3085); Region: DUF3085; pfam11284
1125630013870	Antirestriction protein; Region: Antirestrict; pfam03230
1125630013871	14-3-3 domain; Region: 14-3-3; cl02098
1125630013872	dimer interface [polypeptide binding]; other site
1125630013873	Phage integrase, N-terminal; Region: Phage_int_SAM_2; pfam12834
1125630013874	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1125630013875	active site
1125630013876	Int/Topo IB signature motif; other site
1125630013877	catalytic residues [active]
1125630013878	DNA binding site [nucleotide binding]
1125630013879	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1125630013880	sequence-specific DNA binding site [nucleotide binding]; other site
1125630013881	salt bridge; other site
1125630013882	Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693
1125630013883	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
1125630013884	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1125630013885	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1125630013886	DNA-binding site [nucleotide binding]; DNA binding site
1125630013887	RNA-binding motif; other site
1125630013888	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1125630013889	non-specific DNA binding site [nucleotide binding]; other site
1125630013890	salt bridge; other site
1125630013891	sequence-specific DNA binding site [nucleotide binding]; other site
1125630013892	Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693
1125630013893	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1125630013894	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
1125630013895	integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755
1125630013896	integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756
1125630013897	integrating conjugative element protein, PFL_4709 family; Region: conj_TIGR03757
1125630013898	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902
1125630013899	Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845
1125630013900	conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744
1125630013901	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
1125630013902	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1125630013903	conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751
1125630013904	COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in...; Region: Commd; cl06336
1125630013905	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
1125630013906	Protein of unknown function (DUF3438); Region: DUF3438; pfam11920
1125630013907	integrating conjugative element protein, PFL_4703 family; Region: conj_TIGR03746
1125630013908	conjugative transfer region protein, TIGR03750 family; Region: conj_TIGR03750
1125630013909	Protein of unknown function (DUF2976); Region: DUF2976; cl12739
1125630013910	Protein of unknown function (DUF3262); Region: DUF3262; cl13160
1125630013911	Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686
1125630013912	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
1125630013913	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1125630013914	active site
1125630013915	integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747
1125630013916	conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754
1125630013917	AAA-like domain; Region: AAA_10; pfam12846
1125630013918	Protein of unknown function (DUF2859); Region: DUF2859; pfam11072
1125630013919	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
1125630013920	integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759
1125630013921	conjugative transfer region protein, TIGR03748 family; Region: conj_PilL
1125630013922	Protein of unknown function (DUF3577); Region: DUF3577; pfam12101
1125630013923	Domain of unknown function (DUF1845); Region: DUF1845; pfam08900
1125630013924	Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; cl19875
1125630013925	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1125630013926	G2 box; other site
1125630013927	Switch I region; other site
1125630013928	G3 box; other site
1125630013929	Switch II region; other site
1125630013930	WG containing repeat; Region: WG_beta_rep; pfam14903
1125630013931	Helix-turn-helix domain; Region: HTH_36; pfam13730
1125630013932	Protein of unknown function (DUF2857); Region: DUF2857; pfam11198
1125630013933	ParB-like nuclease domain; Region: ParBc; cl02129
1125630013934	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
1125630013935	replicative DNA helicase; Region: DnaB; TIGR00665
1125630013936	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1125630013937	Protein of unknown function (DUF2884); Region: DUF2884; cl19726
1125630013938	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1125630013939	Walker A motif; other site
1125630013940	ATP binding site [chemical binding]; other site
1125630013941	Walker B motif; other site
1125630013942	DNA binding loops [nucleotide binding]
1125630013943	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1125630013944	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1125630013945	P-loop; other site
1125630013946	Magnesium ion binding site [ion binding]; other site
1125630013947	Transposase; Region: HTH_Tnp_1; cl17663
1125630013948	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1125630013949	Coenzyme A binding pocket [chemical binding]; other site
1125630013950	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
1125630013951	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
1125630013952	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1125630013953	dimer interface [polypeptide binding]; other site
1125630013954	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630013955	catalytic residue [active]
1125630013956	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
1125630013957	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1125630013958	homodimer interface [polypeptide binding]; other site
1125630013959	substrate-cofactor binding pocket; other site
1125630013960	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630013961	catalytic residue [active]
1125630013962	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630013963	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630013964	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477
1125630013965	putative effector binding pocket; other site
1125630013966	putative dimerization interface [polypeptide binding]; other site
1125630013967	Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731
1125630013968	short chain dehydrogenase; Region: adh_short; pfam00106
1125630013969	putative NAD(P) binding site [chemical binding]; other site
1125630013970	homodimer interface [polypeptide binding]; other site
1125630013971	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
1125630013972	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1125630013973	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630013974	homodimer interface [polypeptide binding]; other site
1125630013975	catalytic residue [active]
1125630013976	bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507
1125630013977	CHAP domain; Region: CHAP; pfam05257
1125630013978	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
1125630013979	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1125630013980	Thioredoxin; Region: Thioredoxin_4; cl17273
1125630013981	putative S-transferase; Provisional; Region: PRK11752
1125630013982	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
1125630013983	C-terminal domain interface [polypeptide binding]; other site
1125630013984	GSH binding site (G-site) [chemical binding]; other site
1125630013985	dimer interface [polypeptide binding]; other site
1125630013986	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
1125630013987	dimer interface [polypeptide binding]; other site
1125630013988	N-terminal domain interface [polypeptide binding]; other site
1125630013989	active site
1125630013990	Protein of unknown function (DUF2623); Region: DUF2623; pfam11115
1125630013991	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
1125630013992	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
1125630013993	hypothetical protein; Provisional; Region: PRK05208
1125630013994	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
1125630013995	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001
1125630013996	active site
1125630013997	putative symporter YagG; Provisional; Region: PRK09669; cl15392
1125630013998	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
1125630013999	biopolymer transport protein ExbD; Provisional; Region: PRK11267
1125630014000	biopolymer transport protein ExbB; Provisional; Region: PRK10414
1125630014001	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1125630014002	homodimer interface [polypeptide binding]; other site
1125630014003	substrate-cofactor binding pocket; other site
1125630014004	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630014005	catalytic residue [active]
1125630014006	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1125630014007	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
1125630014008	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1125630014009	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630014010	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630014011	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
1125630014012	dimer interface [polypeptide binding]; other site
1125630014013	active site
1125630014014	metal binding site [ion binding]; metal-binding site
1125630014015	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1125630014016	active site
1125630014017	catalytic tetrad [active]
1125630014018	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1125630014019	Coenzyme A binding pocket [chemical binding]; other site
1125630014020	hypothetical protein; Provisional; Region: PRK01254
1125630014021	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
1125630014022	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
1125630014023	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
1125630014024	FtsI repressor; Provisional; Region: PRK10883
1125630014025	Cupredoxin superfamily; Region: Cupredoxin; cl19115
1125630014026	The second Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_2_CueO_FtsP; cd13867
1125630014027	Domain 1 interface [polypeptide binding]; other site
1125630014028	Domain 3 interface [polypeptide binding]; other site
1125630014029	The third Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_3_CueO_FtsP; cd13890
1125630014030	Domain 2 interface [polypeptide binding]; other site
1125630014031	Domain 1 interface [polypeptide binding]; other site
1125630014032	Type 1 (T1) Cu binding site [ion binding]; other site
1125630014033	trinuclear Cu binding site [ion binding]; other site
1125630014034	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1125630014035	putative acyl-acceptor binding pocket; other site
1125630014036	DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062
1125630014037	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1125630014038	CAP-like domain; other site
1125630014039	active site
1125630014040	primary dimer interface [polypeptide binding]; other site
1125630014041	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630014042	Helix-turn-helix domain; Region: HTH_18; pfam12833
1125630014043	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630014044	DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449
1125630014045	Periplasmic protein with OB-fold [Function unknown]; Region: COG3111
1125630014046	DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336
1125630014047	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1125630014048	active site
1125630014049	phosphorylation site [posttranslational modification]
1125630014050	intermolecular recognition site; other site
1125630014051	dimerization interface [polypeptide binding]; other site
1125630014052	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1125630014053	DNA binding site [nucleotide binding]
1125630014054	sensor protein QseC; Provisional; Region: PRK10337
1125630014055	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1125630014056	dimer interface [polypeptide binding]; other site
1125630014057	phosphorylation site [posttranslational modification]
1125630014058	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1125630014059	ATP binding site [chemical binding]; other site
1125630014060	Mg2+ binding site [ion binding]; other site
1125630014061	G-X-G motif; other site
1125630014062	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
1125630014063	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1125630014064	DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055
1125630014065	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1125630014066	ATP binding site [chemical binding]; other site
1125630014067	Mg2+ binding site [ion binding]; other site
1125630014068	G-X-G motif; other site
1125630014069	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1125630014070	anchoring element; other site
1125630014071	dimer interface [polypeptide binding]; other site
1125630014072	ATP binding site [chemical binding]; other site
1125630014073	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
1125630014074	active site
1125630014075	metal binding site [ion binding]; metal-binding site
1125630014076	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1125630014077	esterase YqiA; Provisional; Region: PRK11071
1125630014078	Esterase/lipase [General function prediction only]; Region: COG1647
1125630014079	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
1125630014080	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
1125630014081	active site
1125630014082	metal binding site [ion binding]; metal-binding site
1125630014083	hexamer interface [polypeptide binding]; other site
1125630014084	putative dehydrogenase; Provisional; Region: PRK11039
1125630014085	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
1125630014086	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1125630014087	dimer interface [polypeptide binding]; other site
1125630014088	ADP-ribose binding site [chemical binding]; other site
1125630014089	active site
1125630014090	nudix motif; other site
1125630014091	metal binding site [ion binding]; metal-binding site
1125630014092	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
1125630014093	Outer membrane efflux protein; Region: OEP; pfam02321
1125630014094	Outer membrane efflux protein; Region: OEP; pfam02321
1125630014095	hypothetical protein; Provisional; Region: PRK11653
1125630014096	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
1125630014097	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
1125630014098	putative active site [active]
1125630014099	metal binding site [ion binding]; metal-binding site
1125630014100	zinc transporter ZupT; Provisional; Region: PRK04201
1125630014101	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353
1125630014102	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960
1125630014103	glycogen synthesis protein GlgS; Provisional; Region: PRK02922
1125630014104	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
1125630014105	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
1125630014106	putative ribose interaction site [chemical binding]; other site
1125630014107	putative ADP binding site [chemical binding]; other site
1125630014108	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
1125630014109	active site
1125630014110	nucleotide binding site [chemical binding]; other site
1125630014111	HIGH motif; other site
1125630014112	KMSKS motif; other site
1125630014113	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
1125630014114	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1125630014115	metal binding triad; other site
1125630014116	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1125630014117	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1125630014118	metal binding triad; other site
1125630014119	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; cl19627
1125630014120	Uncharacterized conserved protein [Function unknown]; Region: COG3025
1125630014121	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
1125630014122	putative active site [active]
1125630014123	putative metal binding residues [ion binding]; other site
1125630014124	signature motif; other site
1125630014125	putative triphosphate binding site [ion binding]; other site
1125630014126	CHAD domain; Region: CHAD; pfam05235
1125630014127	SH3 domain-containing protein; Provisional; Region: PRK10884
1125630014128	Bacterial SH3 domain homologues; Region: SH3b; smart00287
1125630014129	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
1125630014130	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1125630014131	active site
1125630014132	NTP binding site [chemical binding]; other site
1125630014133	metal binding triad [ion binding]; metal-binding site
1125630014134	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1125630014135	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1125630014136	Zn2+ binding site [ion binding]; other site
1125630014137	Mg2+ binding site [ion binding]; other site
1125630014138	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
1125630014139	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
1125630014140	homooctamer interface [polypeptide binding]; other site
1125630014141	active site
1125630014142	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
1125630014143	UreD urease accessory protein; Region: UreD; cl00530
1125630014144	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
1125630014145	alpha-gamma subunit interface [polypeptide binding]; other site
1125630014146	beta-gamma subunit interface [polypeptide binding]; other site
1125630014147	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
1125630014148	gamma-beta subunit interface [polypeptide binding]; other site
1125630014149	alpha-beta subunit interface [polypeptide binding]; other site
1125630014150	urease subunit alpha; Reviewed; Region: ureC; PRK13207
1125630014151	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
1125630014152	subunit interactions [polypeptide binding]; other site
1125630014153	active site
1125630014154	flap region; other site
1125630014155	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
1125630014156	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
1125630014157	dimer interface [polypeptide binding]; other site
1125630014158	catalytic residues [active]
1125630014159	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
1125630014160	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1125630014161	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1125630014162	UGMP family protein; Validated; Region: PRK09604
1125630014163	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
1125630014164	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
1125630014165	DNA primase; Validated; Region: dnaG; PRK05667
1125630014166	CHC2 zinc finger; Region: zf-CHC2; pfam01807
1125630014167	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1125630014168	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1125630014169	active site
1125630014170	metal binding site [ion binding]; metal-binding site
1125630014171	interdomain interaction site; other site
1125630014172	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
1125630014173	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278
1125630014174	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
1125630014175	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
1125630014176	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1125630014177	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
1125630014178	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1125630014179	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1125630014180	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1125630014181	DNA binding residues [nucleotide binding]
1125630014182	G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028
1125630014183	active site
1125630014184	SUMO-1 interface [polypeptide binding]; other site
1125630014185	HdeA/HdeB family; Region: HdeA; pfam06411
1125630014186	DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958
1125630014187	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1125630014188	active site
1125630014189	phosphorylation site [posttranslational modification]
1125630014190	intermolecular recognition site; other site
1125630014191	dimerization interface [polypeptide binding]; other site
1125630014192	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1125630014193	DNA binding residues [nucleotide binding]
1125630014194	dimerization interface [polypeptide binding]; other site
1125630014195	hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959
1125630014196	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1125630014197	substrate binding pocket [chemical binding]; other site
1125630014198	membrane-bound complex binding site; other site
1125630014199	hinge residues; other site
1125630014200	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1125630014201	substrate binding pocket [chemical binding]; other site
1125630014202	membrane-bound complex binding site; other site
1125630014203	hinge residues; other site
1125630014204	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1125630014205	dimer interface [polypeptide binding]; other site
1125630014206	phosphorylation site [posttranslational modification]
1125630014207	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1125630014208	ATP binding site [chemical binding]; other site
1125630014209	Mg2+ binding site [ion binding]; other site
1125630014210	G-X-G motif; other site
1125630014211	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1125630014212	active site
1125630014213	phosphorylation site [posttranslational modification]
1125630014214	intermolecular recognition site; other site
1125630014215	dimerization interface [polypeptide binding]; other site
1125630014216	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1125630014217	putative binding surface; other site
1125630014218	active site
1125630014219	hypothetical protein; Provisional; Region: PRK10316
1125630014220	YfdX protein; Region: YfdX; pfam10938
1125630014221	acid-resistance membrane protein; Provisional; Region: PRK10209
1125630014222	acid-resistance protein; Provisional; Region: hdeB; PRK11566
1125630014223	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
1125630014224	amphipathic channel; other site
1125630014225	Asn-Pro-Ala signature motifs; other site
1125630014226	Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841
1125630014227	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1125630014228	Dehydratase small subunit; Region: Dehydratase_SU; pfam02287
1125630014229	propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042
1125630014230	Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687
1125630014231	alpha-alpha subunit/dimer interface [polypeptide binding]; other site
1125630014232	alpha-beta subunit interface [polypeptide binding]; other site
1125630014233	alpha-gamma subunit interface [polypeptide binding]; other site
1125630014234	active site
1125630014235	substrate and K+ binding site; other site
1125630014236	K+ binding site [ion binding]; other site
1125630014237	cobalamin binding site [chemical binding]; other site
1125630014238	Domain of unknown function (DUF336); Region: DUF336; pfam03928
1125630014239	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
1125630014240	dimer interface [polypeptide binding]; other site
1125630014241	active site
1125630014242	metal binding site [ion binding]; metal-binding site
1125630014243	Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288
1125630014244	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
1125630014245	DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388
1125630014246	GAF domain; Region: GAF; pfam01590
1125630014247	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1125630014248	putative active site [active]
1125630014249	heme pocket [chemical binding]; other site
1125630014250	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1125630014251	Walker A motif; other site
1125630014252	ATP binding site [chemical binding]; other site
1125630014253	Walker B motif; other site
1125630014254	arginine finger; other site
1125630014255	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1125630014256	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
1125630014257	dimer interface [polypeptide binding]; other site
1125630014258	active site
1125630014259	metal binding site [ion binding]; metal-binding site
1125630014260	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468
1125630014261	dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005
1125630014262	dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377
1125630014263	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412
1125630014264	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1125630014265	dimerization domain swap beta strand [polypeptide binding]; other site
1125630014266	regulatory protein interface [polypeptide binding]; other site
1125630014267	active site
1125630014268	regulatory phosphorylation site [posttranslational modification]; other site
1125630014269	PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524
1125630014270	PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1125630014271	dihydroxyacetone kinase, ATP-dependent; Region: dak_ATP; TIGR02361
1125630014272	Dak1 domain; Region: Dak1; cl10557
1125630014273	DAK2 domain; Region: Dak2; pfam02734
1125630014274	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
1125630014275	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
1125630014276	FAD binding pocket [chemical binding]; other site
1125630014277	FAD binding motif [chemical binding]; other site
1125630014278	phosphate binding motif [ion binding]; other site
1125630014279	NAD binding pocket [chemical binding]; other site
1125630014280	Predicted transcriptional regulators [Transcription]; Region: COG1695
1125630014281	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1125630014282	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
1125630014283	inhibitor-cofactor binding pocket; inhibition site
1125630014284	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630014285	catalytic residue [active]
1125630014286	autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486
1125630014287	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
1125630014288	putative active site; other site
1125630014289	catalytic residue [active]
1125630014290	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
1125630014291	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1125630014292	ligand binding site [chemical binding]; other site
1125630014293	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1125630014294	TM-ABC transporter signature motif; other site
1125630014295	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1125630014296	TM-ABC transporter signature motif; other site
1125630014297	autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439
1125630014298	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1125630014299	Walker A/P-loop; other site
1125630014300	ATP binding site [chemical binding]; other site
1125630014301	Q-loop/lid; other site
1125630014302	ABC transporter signature motif; other site
1125630014303	Walker B; other site
1125630014304	D-loop; other site
1125630014305	H-loop/switch region; other site
1125630014306	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1125630014307	transcriptional regulator LsrR; Provisional; Region: PRK15418
1125630014308	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1125630014309	autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939
1125630014310	Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775
1125630014311	putative N- and C-terminal domain interface [polypeptide binding]; other site
1125630014312	putative active site [active]
1125630014313	putative MgATP binding site [chemical binding]; other site
1125630014314	catalytic site [active]
1125630014315	metal binding site [ion binding]; metal-binding site
1125630014316	putative carbohydrate binding site [chemical binding]; other site
1125630014317	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
1125630014318	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
1125630014319	active site
1125630014320	FMN binding site [chemical binding]; other site
1125630014321	2,4-decadienoyl-CoA binding site; other site
1125630014322	catalytic residue [active]
1125630014323	4Fe-4S cluster binding site [ion binding]; other site
1125630014324	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1125630014325	SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001
1125630014326	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1125630014327	S-adenosylmethionine binding site [chemical binding]; other site
1125630014328	Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382
1125630014329	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
1125630014330	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1125630014331	non-specific DNA binding site [nucleotide binding]; other site
1125630014332	salt bridge; other site
1125630014333	sequence-specific DNA binding site [nucleotide binding]; other site
1125630014334	Cupin domain; Region: Cupin_2; pfam07883
1125630014335	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
1125630014336	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1125630014337	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1125630014338	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
1125630014339	serine/threonine transporter SstT; Provisional; Region: PRK13628
1125630014340	Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688
1125630014341	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
1125630014342	galactarate dehydratase; Region: galactar-dH20; TIGR03248
1125630014343	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
1125630014344	glucuronate isomerase; Reviewed; Region: PRK02925
1125630014345	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630014346	D-galactonate transporter; Region: 2A0114; TIGR00893
1125630014347	putative substrate translocation pore; other site
1125630014348	DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523
1125630014349	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1125630014350	DNA-binding site [nucleotide binding]; DNA binding site
1125630014351	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1125630014352	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1125630014353	EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629
1125630014354	Protein of unknown function (DUF1090); Region: DUF1090; pfam06476
1125630014355	Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575
1125630014356	Predicted membrane protein [Function unknown]; Region: COG5393
1125630014357	YqjK-like protein; Region: YqjK; pfam13997
1125630014358	Predicted membrane protein [Function unknown]; Region: COG2259
1125630014359	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
1125630014360	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
1125630014361	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
1125630014362	putative dimer interface [polypeptide binding]; other site
1125630014363	N-terminal domain interface [polypeptide binding]; other site
1125630014364	putative substrate binding pocket (H-site) [chemical binding]; other site
1125630014365	Predicted membrane protein [Function unknown]; Region: COG3152
1125630014366	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630014367	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
1125630014368	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1125630014369	dimerization interface [polypeptide binding]; other site
1125630014370	Pirin-related protein [General function prediction only]; Region: COG1741
1125630014371	Pirin; Region: Pirin; pfam02678
1125630014372	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
1125630014373	dimer interface [polypeptide binding]; other site
1125630014374	tRNA_anti-like; Region: tRNA_anti-like; pfam12869
1125630014375	glycerate kinase I; Provisional; Region: PRK10342
1125630014376	tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559
1125630014377	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
1125630014378	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833
1125630014379	alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558
1125630014380	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630014381	D-galactonate transporter; Region: 2A0114; TIGR00893
1125630014382	putative substrate translocation pore; other site
1125630014383	galactarate dehydratase; Region: galactar-dH20; TIGR03248
1125630014384	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
1125630014385	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
1125630014386	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1125630014387	substrate binding site [chemical binding]; other site
1125630014388	ATP binding site [chemical binding]; other site
1125630014389	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1125630014390	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
1125630014391	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1125630014392	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1125630014393	intersubunit interface [polypeptide binding]; other site
1125630014394	active site
1125630014395	zinc binding site [ion binding]; other site
1125630014396	Na+ binding site [ion binding]; other site
1125630014397	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1125630014398	putative substrate binding site [chemical binding]; other site
1125630014399	putative ATP binding site [chemical binding]; other site
1125630014400	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
1125630014401	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1125630014402	active site
1125630014403	P-loop; other site
1125630014404	phosphorylation site [posttranslational modification]
1125630014405	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1125630014406	bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109
1125630014407	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1125630014408	active site
1125630014409	phosphorylation site [posttranslational modification]
1125630014410	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1125630014411	dimerization domain swap beta strand [polypeptide binding]; other site
1125630014412	regulatory protein interface [polypeptide binding]; other site
1125630014413	active site
1125630014414	regulatory phosphorylation site [posttranslational modification]; other site
1125630014415	D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052
1125630014416	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1125630014417	active site
1125630014418	phosphorylation site [posttranslational modification]
1125630014419	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
1125630014420	active site
1125630014421	P-loop; other site
1125630014422	phosphorylation site [posttranslational modification]
1125630014423	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
1125630014424	galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309
1125630014425	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
1125630014426	putative NAD(P) binding site [chemical binding]; other site
1125630014427	catalytic Zn binding site [ion binding]; other site
1125630014428	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1125630014429	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1125630014430	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1125630014431	Fic family protein [Function unknown]; Region: COG3177
1125630014432	Fic/DOC family; Region: Fic; pfam02661
1125630014433	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1125630014434	putative DNA binding site [nucleotide binding]; other site
1125630014435	putative Zn2+ binding site [ion binding]; other site
1125630014436	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1125630014437	putative SAM binding site [chemical binding]; other site
1125630014438	putative homodimer interface [polypeptide binding]; other site
1125630014439	Putative lipoprotein [General function prediction only]; Region: LppC; COG3107
1125630014440	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
1125630014441	putative ligand binding site [chemical binding]; other site
1125630014442	Uncharacterized protein family UPF0102; Region: UPF0102; cl00516
1125630014443	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
1125630014444	dimer interface [polypeptide binding]; other site
1125630014445	active site
1125630014446	outer membrane lipoprotein; Provisional; Region: PRK11023
1125630014447	BON domain; Region: BON; pfam04972
1125630014448	BON domain; Region: BON; pfam04972
1125630014449	Predicted permease; Region: DUF318; pfam03773
1125630014450	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1125630014451	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1125630014452	NAD(P) binding site [chemical binding]; other site
1125630014453	active site
1125630014454	intracellular protease, PfpI family; Region: PfpI; TIGR01382
1125630014455	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
1125630014456	proposed catalytic triad [active]
1125630014457	conserved cys residue [active]
1125630014458	hypothetical protein; Provisional; Region: PRK03467
1125630014459	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
1125630014460	GIY-YIG motif/motif A; other site
1125630014461	putative active site [active]
1125630014462	putative metal binding site [ion binding]; other site
1125630014463	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1125630014464	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1125630014465	Coenzyme A binding pocket [chemical binding]; other site
1125630014466	Putative lipid carrier protein [Lipid metabolism]; Region: COG3154
1125630014467	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1125630014468	putative protease; Provisional; Region: PRK15447
1125630014469	hypothetical protein; Provisional; Region: PRK10508
1125630014470	tryptophan permease; Provisional; Region: PRK10483
1125630014471	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
1125630014472	ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634
1125630014473	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1125630014474	ATP binding site [chemical binding]; other site
1125630014475	Mg++ binding site [ion binding]; other site
1125630014476	motif III; other site
1125630014477	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1125630014478	nucleotide binding region [chemical binding]; other site
1125630014479	ATP-binding site [chemical binding]; other site
1125630014480	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
1125630014481	putative RNA binding site [nucleotide binding]; other site
1125630014482	lipoprotein NlpI; Provisional; Region: PRK11189
1125630014483	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1125630014484	binding surface
1125630014485	TPR motif; other site
1125630014486	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
1125630014487	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
1125630014488	RNase E interface [polypeptide binding]; other site
1125630014489	trimer interface [polypeptide binding]; other site
1125630014490	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
1125630014491	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
1125630014492	RNase E interface [polypeptide binding]; other site
1125630014493	trimer interface [polypeptide binding]; other site
1125630014494	active site
1125630014495	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1125630014496	putative nucleic acid binding region [nucleotide binding]; other site
1125630014497	G-X-X-G motif; other site
1125630014498	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
1125630014499	RNA binding site [nucleotide binding]; other site
1125630014500	domain interface; other site
1125630014501	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1125630014502	16S/18S rRNA binding site [nucleotide binding]; other site
1125630014503	S13e-L30e interaction site [polypeptide binding]; other site
1125630014504	25S rRNA binding site [nucleotide binding]; other site
1125630014505	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
1125630014506	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1125630014507	RNA binding site [nucleotide binding]; other site
1125630014508	active site
1125630014509	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
1125630014510	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
1125630014511	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1125630014512	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
1125630014513	translation initiation factor IF-2; Validated; Region: infB; PRK05306
1125630014514	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1125630014515	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1125630014516	G1 box; other site
1125630014517	putative GEF interaction site [polypeptide binding]; other site
1125630014518	GTP/Mg2+ binding site [chemical binding]; other site
1125630014519	Switch I region; other site
1125630014520	G2 box; other site
1125630014521	G3 box; other site
1125630014522	Switch II region; other site
1125630014523	G4 box; other site
1125630014524	G5 box; other site
1125630014525	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1125630014526	Translation-initiation factor 2; Region: IF-2; pfam11987
1125630014527	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1125630014528	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
1125630014529	NusA N-terminal domain; Region: NusA_N; pfam08529
1125630014530	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1125630014531	RNA binding site [nucleotide binding]; other site
1125630014532	homodimer interface [polypeptide binding]; other site
1125630014533	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1125630014534	G-X-X-G motif; other site
1125630014535	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1125630014536	G-X-X-G motif; other site
1125630014537	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
1125630014538	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
1125630014539	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
1125630014540	putative oligomer interface [polypeptide binding]; other site
1125630014541	putative RNA binding site [nucleotide binding]; other site
1125630014542	argininosuccinate synthase; Validated; Region: PRK05370
1125630014543	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832
1125630014544	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1125630014545	YfaZ precursor; Region: YfaZ; pfam07437
1125630014546	Preprotein translocase SecG subunit; Region: SecG; pfam03840
1125630014547	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
1125630014548	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1125630014549	active site
1125630014550	substrate binding site [chemical binding]; other site
1125630014551	metal binding site [ion binding]; metal-binding site
1125630014552	Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294
1125630014553	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1125630014554	substrate binding pocket [chemical binding]; other site
1125630014555	dimer interface [polypeptide binding]; other site
1125630014556	inhibitor binding site; inhibition site
1125630014557	ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733
1125630014558	FtsH Extracellular; Region: FtsH_ext; pfam06480
1125630014559	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1125630014560	Walker A motif; other site
1125630014561	ATP binding site [chemical binding]; other site
1125630014562	Walker B motif; other site
1125630014563	arginine finger; other site
1125630014564	Peptidase family M41; Region: Peptidase_M41; pfam01434
1125630014565	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1125630014566	S-adenosylmethionine binding site [chemical binding]; other site
1125630014567	RNA-binding protein YhbY; Provisional; Region: PRK10343
1125630014568	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1125630014569	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1125630014570	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1125630014571	D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113
1125630014572	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
1125630014573	GTPase CgtA; Reviewed; Region: obgE; PRK12298
1125630014574	GTP1/OBG; Region: GTP1_OBG; pfam01018
1125630014575	Obg GTPase; Region: Obg; cd01898
1125630014576	G1 box; other site
1125630014577	GTP/Mg2+ binding site [chemical binding]; other site
1125630014578	Switch I region; other site
1125630014579	G2 box; other site
1125630014580	G3 box; other site
1125630014581	Switch II region; other site
1125630014582	G4 box; other site
1125630014583	G5 box; other site
1125630014584	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1125630014585	EamA-like transporter family; Region: EamA; pfam00892
1125630014586	EamA-like transporter family; Region: EamA; pfam00892
1125630014587	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
1125630014588	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1125630014589	substrate binding pocket [chemical binding]; other site
1125630014590	chain length determination region; other site
1125630014591	substrate-Mg2+ binding site; other site
1125630014592	catalytic residues [active]
1125630014593	aspartate-rich region 1; other site
1125630014594	active site lid residues [active]
1125630014595	aspartate-rich region 2; other site
1125630014596	DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344
1125630014597	EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275
1125630014598	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1125630014599	hinge; other site
1125630014600	active site
1125630014601	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
1125630014602	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1125630014603	anti sigma factor interaction site; other site
1125630014604	regulatory phosphorylation site [posttranslational modification]; other site
1125630014605	ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117
1125630014606	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
1125630014607	mce related protein; Region: MCE; pfam02470
1125630014608	conserved hypothetical integral membrane protein; Region: TIGR00056
1125630014609	putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831
1125630014610	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1125630014611	Walker A/P-loop; other site
1125630014612	ATP binding site [chemical binding]; other site
1125630014613	Q-loop/lid; other site
1125630014614	ABC transporter signature motif; other site
1125630014615	Walker B; other site
1125630014616	D-loop; other site
1125630014617	H-loop/switch region; other site
1125630014618	putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734
1125630014619	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1125630014620	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1125630014621	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
1125630014622	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
1125630014623	putative active site [active]
1125630014624	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
1125630014625	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484
1125630014626	lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893
1125630014627	lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894
1125630014628	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
1125630014629	lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895
1125630014630	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
1125630014631	Walker A/P-loop; other site
1125630014632	ATP binding site [chemical binding]; other site
1125630014633	Q-loop/lid; other site
1125630014634	ABC transporter signature motif; other site
1125630014635	Walker B; other site
1125630014636	D-loop; other site
1125630014637	H-loop/switch region; other site
1125630014638	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
1125630014639	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
1125630014640	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
1125630014641	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
1125630014642	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1125630014643	30S subunit binding site; other site
1125630014644	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1125630014645	active site
1125630014646	phosphorylation site [posttranslational modification]
1125630014647	P-loop ATPase protein family; Region: ATP_bind_2; pfam03668
1125630014648	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1125630014649	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1125630014650	dimerization domain swap beta strand [polypeptide binding]; other site
1125630014651	regulatory protein interface [polypeptide binding]; other site
1125630014652	active site
1125630014653	regulatory phosphorylation site [posttranslational modification]; other site
1125630014654	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
1125630014655	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
1125630014656	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
1125630014657	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
1125630014658	conserved cys residue [active]
1125630014659	aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091
1125630014660	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1125630014661	putative active site [active]
1125630014662	heme pocket [chemical binding]; other site
1125630014663	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1125630014664	dimer interface [polypeptide binding]; other site
1125630014665	phosphorylation site [posttranslational modification]
1125630014666	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1125630014667	ATP binding site [chemical binding]; other site
1125630014668	Mg2+ binding site [ion binding]; other site
1125630014669	G-X-G motif; other site
1125630014670	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1125630014671	active site
1125630014672	phosphorylation site [posttranslational modification]
1125630014673	intermolecular recognition site; other site
1125630014674	dimerization interface [polypeptide binding]; other site
1125630014675	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1125630014676	putative binding surface; other site
1125630014677	active site
1125630014678	mannonate dehydratase; Provisional; Region: PRK03906
1125630014679	D-mannonate dehydratase (UxuA); Region: UxuA; pfam03786
1125630014680	putative oxidoreductase; Provisional; Region: PRK10083
1125630014681	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
1125630014682	putative NAD(P) binding site [chemical binding]; other site
1125630014683	catalytic Zn binding site [ion binding]; other site
1125630014684	structural Zn binding site [ion binding]; other site
1125630014685	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630014686	D-galactonate transporter; Region: 2A0114; TIGR00893
1125630014687	putative substrate translocation pore; other site
1125630014688	radical SAM protein, TIGR01212 family; Region: TIGR01212
1125630014689	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1125630014690	FeS/SAM binding site; other site
1125630014691	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
1125630014692	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
1125630014693	active site
1125630014694	dimer interface [polypeptide binding]; other site
1125630014695	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
1125630014696	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1125630014697	active site
1125630014698	FMN binding site [chemical binding]; other site
1125630014699	substrate binding site [chemical binding]; other site
1125630014700	3Fe-4S cluster binding site [ion binding]; other site
1125630014701	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
1125630014702	domain interface; other site
1125630014703	glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318
1125630014704	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691
1125630014705	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1125630014706	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1125630014707	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1125630014708	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
1125630014709	putative active site cavity [active]
1125630014710	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
1125630014711	stringent starvation protein A; Provisional; Region: sspA; PRK09481
1125630014712	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
1125630014713	C-terminal domain interface [polypeptide binding]; other site
1125630014714	putative GSH binding site (G-site) [chemical binding]; other site
1125630014715	dimer interface [polypeptide binding]; other site
1125630014716	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
1125630014717	dimer interface [polypeptide binding]; other site
1125630014718	N-terminal domain interface [polypeptide binding]; other site
1125630014719	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1125630014720	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1125630014721	23S rRNA interface [nucleotide binding]; other site
1125630014722	L3 interface [polypeptide binding]; other site
1125630014723	Predicted ATPase [General function prediction only]; Region: COG1485
1125630014724	hypothetical protein; Provisional; Region: PRK11677
1125630014725	serine endoprotease; Provisional; Region: PRK10139
1125630014726	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1125630014727	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1125630014728	protein binding site [polypeptide binding]; other site
1125630014729	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1125630014730	serine endoprotease; Provisional; Region: PRK10898
1125630014731	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1125630014732	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1125630014733	protein binding site [polypeptide binding]; other site
1125630014734	malate dehydrogenase; Provisional; Region: PRK05086
1125630014735	Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337
1125630014736	NAD binding site [chemical binding]; other site
1125630014737	dimerization interface [polypeptide binding]; other site
1125630014738	Substrate binding site [chemical binding]; other site
1125630014739	arginine repressor; Provisional; Region: PRK05066
1125630014740	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1125630014741	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1125630014742	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
1125630014743	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
1125630014744	Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048
1125630014745	RNAase interaction site [polypeptide binding]; other site
1125630014746	Fusaric acid resistance protein family; Region: FUSC; pfam04632
1125630014747	p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631
1125630014748	p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559
1125630014749	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1125630014750	HlyD family secretion protein; Region: HlyD_3; pfam13437
1125630014751	efflux system membrane protein; Provisional; Region: PRK11594
1125630014752	transcriptional regulator; Provisional; Region: PRK10632
1125630014753	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630014754	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1125630014755	putative effector binding pocket; other site
1125630014756	dimerization interface [polypeptide binding]; other site
1125630014757	protease TldD; Provisional; Region: tldD; PRK10735
1125630014758	hypothetical protein; Provisional; Region: PRK10899
1125630014759	Protein of unknown function; Region: DUF3971; pfam13116
1125630014760	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1125630014761	ribonuclease G; Provisional; Region: PRK11712
1125630014762	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
1125630014763	homodimer interface [polypeptide binding]; other site
1125630014764	oligonucleotide binding site [chemical binding]; other site
1125630014765	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
1125630014766	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1125630014767	active site
1125630014768	dimer interface [polypeptide binding]; other site
1125630014769	rod shape-determining protein MreD; Provisional; Region: PRK11060
1125630014770	rod shape-determining protein MreC; Region: mreC; TIGR00219
1125630014771	rod shape-determining protein MreB; Provisional; Region: PRK13927
1125630014772	MreB and similar proteins; Region: MreB_like; cd10225
1125630014773	nucleotide binding site [chemical binding]; other site
1125630014774	Mg binding site [ion binding]; other site
1125630014775	putative protofilament interaction site [polypeptide binding]; other site
1125630014776	RodZ interaction site [polypeptide binding]; other site
1125630014777	regulatory protein CsrD; Provisional; Region: PRK11059
1125630014778	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
1125630014779	nucleotidyl binding site; other site
1125630014780	metal binding site [ion binding]; metal-binding site
1125630014781	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1125630014782	sensor protein PhoQ; Provisional; Region: PRK10815
1125630014783	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
1125630014784	YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107
1125630014785	Moco binding site; other site
1125630014786	metal coordination site [ion binding]; other site
1125630014787	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
1125630014788	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
1125630014789	trimer interface [polypeptide binding]; other site
1125630014790	active site
1125630014791	dimer interface [polypeptide binding]; other site
1125630014792	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
1125630014793	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1125630014794	carboxyltransferase (CT) interaction site; other site
1125630014795	biotinylation site [posttranslational modification]; other site
1125630014796	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1125630014797	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1125630014798	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1125630014799	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1125630014800	hypothetical protein; Provisional; Region: PRK10633
1125630014801	Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327
1125630014802	Na binding site [ion binding]; other site
1125630014803	ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406
1125630014804	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1125630014805	S-adenosylmethionine binding site [chemical binding]; other site
1125630014806	tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415
1125630014807	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1125630014808	FMN binding site [chemical binding]; other site
1125630014809	active site
1125630014810	catalytic residues [active]
1125630014811	substrate binding site [chemical binding]; other site
1125630014812	global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430
1125630014813	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
1125630014814	Phage Terminase; Region: Terminase_1; cl19862
1125630014815	Phage terminase, small subunit; Region: Terminase_4; cl01525
1125630014816	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1125630014817	active site
1125630014818	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
1125630014819	oligomerization interface [polypeptide binding]; other site
1125630014820	Phage head-tail joining protein; Region: Phage_H_T_join; cl11461
1125630014821	Phage-related protein [Function unknown]; Region: COG4695
1125630014822	Phage head maturation protease [General function prediction only]; Region: COG3740
1125630014823	Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653
1125630014824	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
1125630014825	Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519
1125630014826	AntA/AntB antirepressor; Region: AntA; pfam08346
1125630014827	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
1125630014828	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
1125630014829	integrase; Provisional; Region: PRK09692
1125630014830	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
1125630014831	active site
1125630014832	Int/Topo IB signature motif; other site
1125630014833	DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975
1125630014834	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1125630014835	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
1125630014836	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
1125630014837	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1125630014838	HlyD family secretion protein; Region: HlyD_3; pfam13437
1125630014839	multidrug efflux system protein AcrB; Provisional; Region: PRK15127
1125630014840	MMPL family; Region: MMPL; cl14618
1125630014841	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1125630014842	Putative periplasmic lipoprotein; Region: DUF1425; cl12345
1125630014843	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
1125630014844	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
1125630014845	trimer interface [polypeptide binding]; other site
1125630014846	putative metal binding site [ion binding]; other site
1125630014847	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
1125630014848	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
1125630014849	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1125630014850	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1125630014851	shikimate binding site; other site
1125630014852	NAD(P) binding site [chemical binding]; other site
1125630014853	tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634
1125630014854	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1125630014855	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
1125630014856	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1125630014857	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1125630014858	hypothetical protein; Validated; Region: PRK03430
1125630014859	hypothetical protein; Provisional; Region: PRK10736
1125630014860	DNA protecting protein DprA; Region: dprA; TIGR00732
1125630014861	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1125630014862	active site
1125630014863	catalytic residues [active]
1125630014864	metal binding site [ion binding]; metal-binding site
1125630014865	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1125630014866	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1125630014867	putative active site [active]
1125630014868	substrate binding site [chemical binding]; other site
1125630014869	putative cosubstrate binding site; other site
1125630014870	catalytic site [active]
1125630014871	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1125630014872	substrate binding site [chemical binding]; other site
1125630014873	16S rRNA methyltransferase B; Provisional; Region: PRK10901
1125630014874	N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620
1125630014875	putative RNA binding site [nucleotide binding]; other site
1125630014876	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1125630014877	S-adenosylmethionine binding site [chemical binding]; other site
1125630014878	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
1125630014879	TrkA-N domain; Region: TrkA_N; pfam02254
1125630014880	TrkA-C domain; Region: TrkA_C; pfam02080
1125630014881	TrkA-N domain; Region: TrkA_N; pfam02254
1125630014882	TrkA-C domain; Region: TrkA_C; pfam02080
1125630014883	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
1125630014884	zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514
1125630014885	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
1125630014886	DNA binding residues [nucleotide binding]
1125630014887	dimer interface [polypeptide binding]; other site
1125630014888	metal binding site [ion binding]; metal-binding site
1125630014889	hypothetical protein; Provisional; Region: PRK10203
1125630014890	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1125630014891	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1125630014892	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1125630014893	alphaNTD homodimer interface [polypeptide binding]; other site
1125630014894	alphaNTD - beta interaction site [polypeptide binding]; other site
1125630014895	alphaNTD - beta' interaction site [polypeptide binding]; other site
1125630014896	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1125630014897	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1125630014898	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1125630014899	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1125630014900	RNA binding surface [nucleotide binding]; other site
1125630014901	Ribosomal protein S11; Region: Ribosomal_S11; cl00332
1125630014902	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
1125630014903	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1125630014904	SecY translocase; Region: SecY; pfam00344
1125630014905	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1125630014906	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
1125630014907	23S rRNA binding site [nucleotide binding]; other site
1125630014908	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
1125630014909	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1125630014910	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1125630014911	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1125630014912	23S rRNA interface [nucleotide binding]; other site
1125630014913	5S rRNA interface [nucleotide binding]; other site
1125630014914	L27 interface [polypeptide binding]; other site
1125630014915	L5 interface [polypeptide binding]; other site
1125630014916	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1125630014917	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1125630014918	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1125630014919	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1125630014920	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
1125630014921	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1125630014922	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1125630014923	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1125630014924	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1125630014925	RNA binding site [nucleotide binding]; other site
1125630014926	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
1125630014927	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1125630014928	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
1125630014929	23S rRNA interface [nucleotide binding]; other site
1125630014930	putative translocon interaction site; other site
1125630014931	signal recognition particle (SRP54) interaction site; other site
1125630014932	L23 interface [polypeptide binding]; other site
1125630014933	trigger factor interaction site; other site
1125630014934	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1125630014935	23S rRNA interface [nucleotide binding]; other site
1125630014936	5S rRNA interface [nucleotide binding]; other site
1125630014937	putative antibiotic binding site [chemical binding]; other site
1125630014938	L25 interface [polypeptide binding]; other site
1125630014939	L27 interface [polypeptide binding]; other site
1125630014940	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1125630014941	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1125630014942	G-X-X-G motif; other site
1125630014943	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1125630014944	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1125630014945	protein-rRNA interface [nucleotide binding]; other site
1125630014946	putative translocon binding site; other site
1125630014947	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
1125630014948	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1125630014949	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1125630014950	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1125630014951	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1125630014952	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1125630014953	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
1125630014954	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1125630014955	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
1125630014956	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
1125630014957	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
1125630014958	Ferritin-like domain; Region: Ferritin; pfam00210
1125630014959	heme binding site [chemical binding]; other site
1125630014960	ferroxidase pore; other site
1125630014961	ferroxidase diiron center [ion binding]; other site
1125630014962	bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509
1125630014963	elongation factor Tu; Reviewed; Region: PRK00049
1125630014964	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1125630014965	G1 box; other site
1125630014966	GEF interaction site [polypeptide binding]; other site
1125630014967	GTP/Mg2+ binding site [chemical binding]; other site
1125630014968	Switch I region; other site
1125630014969	G2 box; other site
1125630014970	G3 box; other site
1125630014971	Switch II region; other site
1125630014972	G4 box; other site
1125630014973	G5 box; other site
1125630014974	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1125630014975	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1125630014976	Antibiotic Binding Site [chemical binding]; other site
1125630014977	elongation factor G; Reviewed; Region: PRK00007
1125630014978	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1125630014979	G1 box; other site
1125630014980	putative GEF interaction site [polypeptide binding]; other site
1125630014981	GTP/Mg2+ binding site [chemical binding]; other site
1125630014982	Switch I region; other site
1125630014983	G2 box; other site
1125630014984	G3 box; other site
1125630014985	Switch II region; other site
1125630014986	G4 box; other site
1125630014987	G5 box; other site
1125630014988	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1125630014989	Elongation Factor G, domain II; Region: EFG_II; pfam14492
1125630014990	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1125630014991	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1125630014992	30S ribosomal protein S7; Validated; Region: PRK05302
1125630014993	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1125630014994	S17 interaction site [polypeptide binding]; other site
1125630014995	S8 interaction site; other site
1125630014996	16S rRNA interaction site [nucleotide binding]; other site
1125630014997	streptomycin interaction site [chemical binding]; other site
1125630014998	23S rRNA interaction site [nucleotide binding]; other site
1125630014999	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1125630015000	DsrH like protein; Region: DsrH; cl17347
1125630015001	sulfur relay protein TusC; Validated; Region: PRK00211
1125630015002	sulfur transfer complex subunit TusD; Validated; Region: PRK00207
1125630015003	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
1125630015004	YheO-like PAS domain; Region: PAS_6; pfam08348
1125630015005	HTH domain; Region: HTH_22; pfam13309
1125630015006	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902
1125630015007	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
1125630015008	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1125630015009	phi X174 lysis protein; Provisional; Region: PRK02793
1125630015010	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
1125630015011	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10737
1125630015012	Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529
1125630015013	glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659
1125630015014	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1125630015015	TrkA-N domain; Region: TrkA_N; pfam02254
1125630015016	glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930
1125630015017	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
1125630015018	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1125630015019	ABC transporter; Region: ABC_tran_2; pfam12848
1125630015020	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1125630015021	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
1125630015022	putative hydrolase; Provisional; Region: PRK10985
1125630015023	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
1125630015024	hypothetical protein; Provisional; Region: PRK04966
1125630015025	phosphoribulokinase; Provisional; Region: PRK15453
1125630015026	active site
1125630015027	OsmC-like protein; Region: OsmC; cl00767
1125630015028	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
1125630015029	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1125630015030	ligand binding site [chemical binding]; other site
1125630015031	flexible hinge region; other site
1125630015032	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1125630015033	putative switch regulator; other site
1125630015034	non-specific DNA interactions [nucleotide binding]; other site
1125630015035	DNA binding site [nucleotide binding]
1125630015036	sequence specific DNA binding site [nucleotide binding]; other site
1125630015037	putative cAMP binding site [chemical binding]; other site
1125630015038	integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667
1125630015039	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
1125630015040	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1125630015041	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
1125630015042	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1125630015043	inhibitor-cofactor binding pocket; inhibition site
1125630015044	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630015045	catalytic residue [active]
1125630015046	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
1125630015047	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1125630015048	glutamine binding [chemical binding]; other site
1125630015049	catalytic triad [active]
1125630015050	cell filamentation protein Fic; Provisional; Region: PRK10347
1125630015051	hypothetical protein; Provisional; Region: PRK10204
1125630015052	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
1125630015053	substrate binding site [chemical binding]; other site
1125630015054	putative transporter; Provisional; Region: PRK03699
1125630015055	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630015056	putative substrate translocation pore; other site
1125630015057	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
1125630015058	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
1125630015059	active site
1125630015060	nitrite reductase subunit NirD; Provisional; Region: PRK14989
1125630015061	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1125630015062	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1125630015063	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
1125630015064	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
1125630015065	siroheme synthase; Provisional; Region: cysG; PRK10637
1125630015066	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
1125630015067	Sirohaem biosynthesis protein central; Region: Sirohm_synth_M; pfam14824
1125630015068	Sirohaem synthase dimerization region; Region: CysG_dimeriser; pfam10414
1125630015069	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1125630015070	active site
1125630015071	SAM binding site [chemical binding]; other site
1125630015072	homodimer interface [polypeptide binding]; other site
1125630015073	tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927
1125630015074	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1125630015075	active site
1125630015076	HIGH motif; other site
1125630015077	dimer interface [polypeptide binding]; other site
1125630015078	KMSKS motif; other site
1125630015079	phosphoglycolate phosphatase; Provisional; Region: PRK13222
1125630015080	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
1125630015081	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1125630015082	motif II; other site
1125630015083	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1125630015084	substrate binding site [chemical binding]; other site
1125630015085	hexamer interface [polypeptide binding]; other site
1125630015086	metal binding site [ion binding]; metal-binding site
1125630015087	DNA adenine methylase; Provisional; Region: PRK10904
1125630015088	cell division protein DamX; Validated; Region: PRK10905
1125630015089	Sporulation related domain; Region: SPOR; pfam05036
1125630015090	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
1125630015091	active site
1125630015092	dimer interface [polypeptide binding]; other site
1125630015093	metal binding site [ion binding]; metal-binding site
1125630015094	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
1125630015095	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1125630015096	ADP binding site [chemical binding]; other site
1125630015097	magnesium binding site [ion binding]; other site
1125630015098	putative shikimate binding site; other site
1125630015099	outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560
1125630015100	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1125630015101	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1125630015102	Fimbrial assembly protein (PilN); Region: PilN; cl19830
1125630015103	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
1125630015104	penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636
1125630015105	Transglycosylase; Region: Transgly; pfam00912
1125630015106	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1125630015107	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
1125630015108	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1125630015109	ADP-ribose binding site [chemical binding]; other site
1125630015110	dimer interface [polypeptide binding]; other site
1125630015111	active site
1125630015112	nudix motif; other site
1125630015113	metal binding site [ion binding]; metal-binding site
1125630015114	Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095
1125630015115	GMP/IMP nucleotidase; Provisional; Region: PRK14988
1125630015116	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
1125630015117	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1125630015118	motif II; other site
1125630015119	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1125630015120	RNA binding surface [nucleotide binding]; other site
1125630015121	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
1125630015122	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
1125630015123	dimerization interface [polypeptide binding]; other site
1125630015124	domain crossover interface; other site
1125630015125	redox-dependent activation switch; other site
1125630015126	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
1125630015127	active site
1125630015128	substrate-binding site [chemical binding]; other site
1125630015129	metal-binding site [ion binding]
1125630015130	ATP binding site [chemical binding]; other site
1125630015131	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
1125630015132	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1125630015133	dimerization interface [polypeptide binding]; other site
1125630015134	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1125630015135	dimer interface [polypeptide binding]; other site
1125630015136	phosphorylation site [posttranslational modification]
1125630015137	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1125630015138	ATP binding site [chemical binding]; other site
1125630015139	Mg2+ binding site [ion binding]; other site
1125630015140	G-X-G motif; other site
1125630015141	osmolarity response regulator; Provisional; Region: ompR; PRK09468
1125630015142	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1125630015143	active site
1125630015144	phosphorylation site [posttranslational modification]
1125630015145	intermolecular recognition site; other site
1125630015146	dimerization interface [polypeptide binding]; other site
1125630015147	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1125630015148	DNA binding site [nucleotide binding]
1125630015149	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
1125630015150	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1125630015151	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1125630015152	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
1125630015153	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
1125630015154	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
1125630015155	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
1125630015156	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
1125630015157	RNA binding site [nucleotide binding]; other site
1125630015158	FeoA domain; Region: FeoA; cl00838
1125630015159	ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554
1125630015160	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
1125630015161	G1 box; other site
1125630015162	GTP/Mg2+ binding site [chemical binding]; other site
1125630015163	Switch I region; other site
1125630015164	G2 box; other site
1125630015165	G3 box; other site
1125630015166	Switch II region; other site
1125630015167	G4 box; other site
1125630015168	G5 box; other site
1125630015169	Nucleoside recognition; Region: Gate; pfam07670
1125630015170	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
1125630015171	Nucleoside recognition; Region: Gate; pfam07670
1125630015172	ferrous iron transport protein FeoC; Provisional; Region: PRK15431
1125630015173	Protein of unknown function (DUF1471); Region: DUF1471; cl11507
1125630015174	carboxylesterase BioH; Provisional; Region: PRK10349
1125630015175	Putative lysophospholipase; Region: Hydrolase_4; cl19140
1125630015176	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
1125630015177	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1125630015178	active site
1125630015179	Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190
1125630015180	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
1125630015181	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
1125630015182	high-affinity gluconate transporter; Provisional; Region: PRK14984
1125630015183	GntP family permease; Region: GntP_permease; pfam02447
1125630015184	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
1125630015185	4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711
1125630015186	maltodextrin phosphorylase; Provisional; Region: PRK14985
1125630015187	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
1125630015188	homodimer interface [polypeptide binding]; other site
1125630015189	active site pocket [active]
1125630015190	transcriptional regulator MalT; Provisional; Region: PRK04841
1125630015191	AAA ATPase domain; Region: AAA_16; pfam13191
1125630015192	Cohesin loading factor; Region: Cohesin_load; pfam10345
1125630015193	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1125630015194	DNA binding residues [nucleotide binding]
1125630015195	dimerization interface [polypeptide binding]; other site
1125630015196	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
1125630015197	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1125630015198	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1125630015199	intramembrane serine protease GlpG; Provisional; Region: PRK10907
1125630015200	Protein of unknown function (DUF3582); Region: DUF3582; pfam12122
1125630015201	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
1125630015202	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
1125630015203	active site residue [active]
1125630015204	FAD dependent oxidoreductase; Region: DAO; pfam01266
1125630015205	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
1125630015206	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
1125630015207	glycogen phosphorylase; Provisional; Region: PRK14986
1125630015208	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
1125630015209	homodimer interface [polypeptide binding]; other site
1125630015210	active site pocket [active]
1125630015211	glycogen synthase; Provisional; Region: glgA; PRK00654
1125630015212	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
1125630015213	ADP-binding pocket [chemical binding]; other site
1125630015214	homodimer interface [polypeptide binding]; other site
1125630015215	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
1125630015216	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
1125630015217	ligand binding site; other site
1125630015218	oligomer interface; other site
1125630015219	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
1125630015220	dimer interface [polypeptide binding]; other site
1125630015221	N-terminal domain interface [polypeptide binding]; other site
1125630015222	sulfate 1 binding site; other site
1125630015223	glycogen debranching enzyme; Provisional; Region: PRK03705
1125630015224	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
1125630015225	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
1125630015226	active site
1125630015227	catalytic site [active]
1125630015228	glycogen branching enzyme; Provisional; Region: PRK05402
1125630015229	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
1125630015230	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
1125630015231	active site
1125630015232	catalytic site [active]
1125630015233	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
1125630015234	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
1125630015235	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1125630015236	Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774
1125630015237	low affinity gluconate transporter; Provisional; Region: PRK10472
1125630015238	GntP family permease; Region: GntP_permease; pfam02447
1125630015239	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
1125630015240	ATP-binding site [chemical binding]; other site
1125630015241	Gluconate-6-phosphate binding site [chemical binding]; other site
1125630015242	gluconate operon transcriptional regulator; Provisional; Region: PRK14987
1125630015243	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1125630015244	DNA binding site [nucleotide binding]
1125630015245	domain linker motif; other site
1125630015246	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
1125630015247	putative ligand binding site [chemical binding]; other site
1125630015248	putative dimerization interface [polypeptide binding]; other site
1125630015249	Pirin-related protein [General function prediction only]; Region: COG1741
1125630015250	Pirin; Region: Pirin; pfam02678
1125630015251	putative oxidoreductase; Provisional; Region: PRK10206
1125630015252	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1125630015253	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1125630015254	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
1125630015255	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1125630015256	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1125630015257	Coenzyme A binding pocket [chemical binding]; other site
1125630015258	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1125630015259	gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615
1125630015260	Protein of unknown function (DUF2756); Region: DUF2756; pfam10956
1125630015261	cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454
1125630015262	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
1125630015263	putative active site [active]
1125630015264	catalytic site [active]
1125630015265	putative metal binding site [ion binding]; other site
1125630015266	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1125630015267	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1125630015268	Walker A/P-loop; other site
1125630015269	ATP binding site [chemical binding]; other site
1125630015270	Q-loop/lid; other site
1125630015271	ABC transporter signature motif; other site
1125630015272	Walker B; other site
1125630015273	D-loop; other site
1125630015274	H-loop/switch region; other site
1125630015275	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1125630015276	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630015277	dimer interface [polypeptide binding]; other site
1125630015278	conserved gate region; other site
1125630015279	putative PBP binding loops; other site
1125630015280	ABC-ATPase subunit interface; other site
1125630015281	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1125630015282	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630015283	dimer interface [polypeptide binding]; other site
1125630015284	conserved gate region; other site
1125630015285	putative PBP binding loops; other site
1125630015286	ABC-ATPase subunit interface; other site
1125630015287	glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974
1125630015288	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1125630015289	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
1125630015290	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
1125630015291	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614
1125630015292	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1125630015293	Walker A/P-loop; other site
1125630015294	ATP binding site [chemical binding]; other site
1125630015295	Q-loop/lid; other site
1125630015296	ABC transporter signature motif; other site
1125630015297	Walker B; other site
1125630015298	D-loop; other site
1125630015299	H-loop/switch region; other site
1125630015300	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
1125630015301	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1125630015302	Walker A/P-loop; other site
1125630015303	ATP binding site [chemical binding]; other site
1125630015304	Q-loop/lid; other site
1125630015305	ABC transporter signature motif; other site
1125630015306	Walker B; other site
1125630015307	D-loop; other site
1125630015308	H-loop/switch region; other site
1125630015309	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
1125630015310	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
1125630015311	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1125630015312	TM-ABC transporter signature motif; other site
1125630015313	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1125630015314	TM-ABC transporter signature motif; other site
1125630015315	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
1125630015316	dimerization interface [polypeptide binding]; other site
1125630015317	Receptor family ligand binding region; Region: ANF_receptor; pfam01094
1125630015318	ligand binding site [chemical binding]; other site
1125630015319	Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568
1125630015320	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1125630015321	Coenzyme A binding pocket [chemical binding]; other site
1125630015322	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
1125630015323	dimerization interface [polypeptide binding]; other site
1125630015324	Receptor family ligand binding region; Region: ANF_receptor; pfam01094
1125630015325	ligand binding site [chemical binding]; other site
1125630015326	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
1125630015327	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
1125630015328	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1125630015329	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
1125630015330	inhibitor-cofactor binding pocket; inhibition site
1125630015331	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630015332	catalytic residue [active]
1125630015333	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1125630015334	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1125630015335	DNA-binding site [nucleotide binding]; DNA binding site
1125630015336	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1125630015337	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630015338	homodimer interface [polypeptide binding]; other site
1125630015339	catalytic residue [active]
1125630015340	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
1125630015341	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1125630015342	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1125630015343	DNA binding residues [nucleotide binding]
1125630015344	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
1125630015345	putative protein insertion permease FtsX; Region: ftsX; TIGR00439
1125630015346	cell division protein FtsE; Provisional; Region: PRK10908
1125630015347	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1125630015348	Walker A/P-loop; other site
1125630015349	ATP binding site [chemical binding]; other site
1125630015350	Q-loop/lid; other site
1125630015351	ABC transporter signature motif; other site
1125630015352	Walker B; other site
1125630015353	D-loop; other site
1125630015354	H-loop/switch region; other site
1125630015355	Mitochondria Localisation Sequence; Region: AIF-MLS; pfam14962
1125630015356	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
1125630015357	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
1125630015358	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1125630015359	P loop; other site
1125630015360	GTP binding site [chemical binding]; other site
1125630015361	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1125630015362	S-adenosylmethionine binding site [chemical binding]; other site
1125630015363	hypothetical protein; Provisional; Region: PRK10910
1125630015364	Protein of unknown function (DUF2500); Region: DUF2500; pfam10694
1125630015365	Predicted membrane protein [Function unknown]; Region: COG3714
1125630015366	zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033
1125630015367	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1125630015368	metal-binding site [ion binding]
1125630015369	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1125630015370	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
1125630015371	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
1125630015372	CPxP  motif; other site
1125630015373	hypothetical protein; Provisional; Region: PRK11212
1125630015374	hypothetical protein; Provisional; Region: PRK11615
1125630015375	major facilitator superfamily transporter; Provisional; Region: PRK05122
1125630015376	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630015377	putative substrate translocation pore; other site
1125630015378	potential frameshift: common BLAST hit: gi|238896937|ref|YP_002921682.1| putative PerM-family permease
1125630015379	Domain of unknown function DUF20; Region: UPF0118; cl00465
1125630015380	Domain of unknown function DUF20; Region: UPF0118; cl00465
1125630015381	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
1125630015382	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051
1125630015383	4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279
1125630015384	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
1125630015385	4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394
1125630015386	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
1125630015387	bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125
1125630015388	ArnA, N-terminal formyltransferase domain; Region: FMT_core_ArnA_N; cd08644
1125630015389	substrate binding site [chemical binding]; other site
1125630015390	cosubstrate binding site; other site
1125630015391	catalytic site [active]
1125630015392	C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702
1125630015393	active site
1125630015394	hexamer interface [polypeptide binding]; other site
1125630015395	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
1125630015396	NAD binding site [chemical binding]; other site
1125630015397	substrate binding site [chemical binding]; other site
1125630015398	active site
1125630015399	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1125630015400	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1125630015401	Ligand binding site; other site
1125630015402	Putative Catalytic site; other site
1125630015403	DXD motif; other site
1125630015404	lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407
1125630015405	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1125630015406	inhibitor-cofactor binding pocket; inhibition site
1125630015407	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630015408	catalytic residue [active]
1125630015409	Phenolic Acid Decarboxylase; Region: PAD; cd14241
1125630015410	active site
1125630015411	dimer interface [polypeptide binding]; other site
1125630015412	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630015413	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630015414	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1125630015415	dimerization interface [polypeptide binding]; other site
1125630015416	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1125630015417	The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489
1125630015418	substrate binding site [chemical binding]; other site
1125630015419	nickel transporter permease NikB; Provisional; Region: PRK10352
1125630015420	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630015421	dimer interface [polypeptide binding]; other site
1125630015422	conserved gate region; other site
1125630015423	putative PBP binding loops; other site
1125630015424	ABC-ATPase subunit interface; other site
1125630015425	nickel transporter permease NikC; Provisional; Region: nikC; PRK10417
1125630015426	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1125630015427	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630015428	dimer interface [polypeptide binding]; other site
1125630015429	conserved gate region; other site
1125630015430	putative PBP binding loops; other site
1125630015431	ABC-ATPase subunit interface; other site
1125630015432	nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418
1125630015433	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1125630015434	Walker A/P-loop; other site
1125630015435	ATP binding site [chemical binding]; other site
1125630015436	Q-loop/lid; other site
1125630015437	ABC transporter signature motif; other site
1125630015438	Walker B; other site
1125630015439	D-loop; other site
1125630015440	H-loop/switch region; other site
1125630015441	nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419
1125630015442	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1125630015443	Walker A/P-loop; other site
1125630015444	ATP binding site [chemical binding]; other site
1125630015445	Q-loop/lid; other site
1125630015446	ABC transporter signature motif; other site
1125630015447	Walker B; other site
1125630015448	D-loop; other site
1125630015449	H-loop/switch region; other site
1125630015450	nickel responsive regulator; Provisional; Region: PRK02967
1125630015451	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
1125630015452	FOG: CBS domain [General function prediction only]; Region: COG0517
1125630015453	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1125630015454	Divalent cation transporter; Region: MgtE; pfam01769
1125630015455	Predicted flavoproteins [General function prediction only]; Region: COG2081
1125630015456	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1125630015457	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1125630015458	universal stress protein UspB; Provisional; Region: PRK04960
1125630015459	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1125630015460	Ligand Binding Site [chemical binding]; other site
1125630015461	dipeptide/tripeptide permease B; Provisional; Region: PRK10207
1125630015462	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
1125630015463	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630015464	putative substrate translocation pore; other site
1125630015465	putative methyltransferase; Provisional; Region: PRK10742
1125630015466	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1125630015467	S-adenosylmethionine binding site [chemical binding]; other site
1125630015468	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
1125630015469	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
1125630015470	active site
1125630015471	Zn binding site [ion binding]; other site
1125630015472	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
1125630015473	active site
1125630015474	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1125630015475	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
1125630015476	glutathione reductase; Validated; Region: PRK06116
1125630015477	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1125630015478	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1125630015479	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
1125630015480	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1125630015481	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
1125630015482	putative C-terminal domain interface [polypeptide binding]; other site
1125630015483	putative GSH binding site (G-site) [chemical binding]; other site
1125630015484	putative dimer interface [polypeptide binding]; other site
1125630015485	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
1125630015486	N-terminal domain interface [polypeptide binding]; other site
1125630015487	dimer interface [polypeptide binding]; other site
1125630015488	substrate binding pocket (H-site) [chemical binding]; other site
1125630015489	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183
1125630015490	putative active site [active]
1125630015491	metal binding site [ion binding]; metal-binding site
1125630015492	trehalase; Provisional; Region: treF; PRK13270
1125630015493	Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626
1125630015494	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1125630015495	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1125630015496	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1125630015497	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1125630015498	NAD(P) binding site [chemical binding]; other site
1125630015499	active site
1125630015500	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1125630015501	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630015502	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
1125630015503	putative effector binding pocket; other site
1125630015504	putative dimerization interface [polypeptide binding]; other site
1125630015505	inner membrane protein YhjD; Region: TIGR00766
1125630015506	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630015507	metabolite-proton symporter; Region: 2A0106; TIGR00883
1125630015508	putative substrate translocation pore; other site
1125630015509	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
1125630015510	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1125630015511	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1125630015512	substrate binding site [chemical binding]; other site
1125630015513	ATP binding site [chemical binding]; other site
1125630015514	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1125630015515	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1125630015516	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
1125630015517	putative diguanylate cyclase; Provisional; Region: PRK13561
1125630015518	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1125630015519	dimerization interface [polypeptide binding]; other site
1125630015520	diguanylate cyclase; Region: GGDEF; smart00267
1125630015521	metal binding site [ion binding]; metal-binding site
1125630015522	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1125630015523	cellulose synthase subunit BcsC; Provisional; Region: PRK11447
1125630015524	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1125630015525	TPR motif; other site
1125630015526	binding surface
1125630015527	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1125630015528	binding surface
1125630015529	TPR motif; other site
1125630015530	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1125630015531	binding surface
1125630015532	TPR motif; other site
1125630015533	Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420
1125630015534	endo-1,4-D-glucanase; Provisional; Region: PRK11097
1125630015535	cellulose synthase regulator protein; Provisional; Region: PRK11114
1125630015536	cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498
1125630015537	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1125630015538	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
1125630015539	DXD motif; other site
1125630015540	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1125630015541	PilZ domain; Region: PilZ; pfam07238
1125630015542	cell division protein; Provisional; Region: PRK10037
1125630015543	YhjQ protein; Region: YhjQ; pfam06564
1125630015544	Protein of unknown function (DUF2629); Region: DUF2629; pfam10945
1125630015545	Protein of unknown function (DUF2819); Region: DUF2819; cl17862
1125630015546	Protein of unknown function (DUF2636); Region: DUF2636; pfam11120
1125630015547	Protein of unknown function (DUF3260); Region: DUF3260; pfam11658
1125630015548	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; pfam01270
1125630015549	Cellulose synthase subunit D; Region: Cellsynth_D; pfam03500
1125630015550	cellulose synthase subunit BcsC; Provisional; Region: PRK11447
1125630015551	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1125630015552	TPR motif; other site
1125630015553	binding surface
1125630015554	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1125630015555	binding surface
1125630015556	TPR motif; other site
1125630015557	Tetratricopeptide repeat; Region: TPR_14; pfam13428
1125630015558	Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420
1125630015559	cellulose synthase regulator protein; Provisional; Region: PRK11114
1125630015560	cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030
1125630015561	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
1125630015562	DXD motif; other site
1125630015563	PilZ domain; Region: PilZ; pfam07238
1125630015564	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1125630015565	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1125630015566	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994
1125630015567	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
1125630015568	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1125630015569	Walker A/P-loop; other site
1125630015570	ATP binding site [chemical binding]; other site
1125630015571	Q-loop/lid; other site
1125630015572	ABC transporter signature motif; other site
1125630015573	Walker B; other site
1125630015574	D-loop; other site
1125630015575	H-loop/switch region; other site
1125630015576	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1125630015577	dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022
1125630015578	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1125630015579	Walker A/P-loop; other site
1125630015580	ATP binding site [chemical binding]; other site
1125630015581	Q-loop/lid; other site
1125630015582	ABC transporter signature motif; other site
1125630015583	Walker B; other site
1125630015584	D-loop; other site
1125630015585	H-loop/switch region; other site
1125630015586	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1125630015587	dipeptide transporter; Provisional; Region: PRK10913
1125630015588	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1125630015589	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630015590	dimer interface [polypeptide binding]; other site
1125630015591	conserved gate region; other site
1125630015592	putative PBP binding loops; other site
1125630015593	ABC-ATPase subunit interface; other site
1125630015594	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1125630015595	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630015596	dimer interface [polypeptide binding]; other site
1125630015597	conserved gate region; other site
1125630015598	putative PBP binding loops; other site
1125630015599	ABC-ATPase subunit interface; other site
1125630015600	antimicrobial peptide ABC transporter periplasmic binding protein SapA; Provisional; Region: PRK15109
1125630015601	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
1125630015602	peptide binding site [polypeptide binding]; other site
1125630015603	putative transposase OrfB; Reviewed; Region: PHA02517
1125630015604	HTH-like domain; Region: HTH_21; pfam13276
1125630015605	Integrase core domain; Region: rve; pfam00665
1125630015606	Integrase core domain; Region: rve_2; pfam13333
1125630015607	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1125630015608	Helix-turn-helix domain; Region: HTH_28; pfam13518
1125630015609	Helix-turn-helix domain; Region: HTH_28; pfam13518
1125630015610	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1125630015611	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1125630015612	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1125630015613	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1125630015614	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1125630015615	phosphoethanolamine transferase; Provisional; Region: PRK11560
1125630015616	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
1125630015617	Sulfatase; Region: Sulfatase; pfam00884
1125630015618	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
1125630015619	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630015620	putative substrate translocation pore; other site
1125630015621	Autotransporter beta-domain; Region: Autotransporter; cl17461
1125630015622	3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353
1125630015623	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1125630015624	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1125630015625	Coenzyme A binding pocket [chemical binding]; other site
1125630015626	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
1125630015627	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
1125630015628	molybdopterin cofactor binding site [chemical binding]; other site
1125630015629	substrate binding site [chemical binding]; other site
1125630015630	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
1125630015631	molybdopterin cofactor binding site; other site
1125630015632	putative outer membrane lipoprotein; Provisional; Region: PRK10510
1125630015633	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1125630015634	ligand binding site [chemical binding]; other site
1125630015635	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1125630015636	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1125630015637	DNA binding site [nucleotide binding]
1125630015638	domain linker motif; other site
1125630015639	Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283
1125630015640	putative dimerization interface [polypeptide binding]; other site
1125630015641	putative ligand binding site [chemical binding]; other site
1125630015642	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1125630015643	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1125630015644	substrate binding site [chemical binding]; other site
1125630015645	ATP binding site [chemical binding]; other site
1125630015646	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630015647	D-galactonate transporter; Region: 2A0114; TIGR00893
1125630015648	putative substrate translocation pore; other site
1125630015649	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1125630015650	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
1125630015651	dimerization interface [polypeptide binding]; other site
1125630015652	ligand binding site [chemical binding]; other site
1125630015653	NADP binding site [chemical binding]; other site
1125630015654	catalytic site [active]
1125630015655	Protein of unknown function (DUF3053); Region: DUF3053; pfam11254
1125630015656	benzoate transport; Region: 2A0115; TIGR00895
1125630015657	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630015658	putative substrate translocation pore; other site
1125630015659	Predicted transcriptional regulator [Transcription]; Region: COG2944
1125630015660	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1125630015661	salt bridge; other site
1125630015662	non-specific DNA binding site [nucleotide binding]; other site
1125630015663	sequence-specific DNA binding site [nucleotide binding]; other site
1125630015664	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1125630015665	DNA-binding site [nucleotide binding]; DNA binding site
1125630015666	RNA-binding motif; other site
1125630015667	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1125630015668	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1125630015669	ABC transporter; Region: ABC_tran_2; pfam12848
1125630015670	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1125630015671	Q-loop/lid; other site
1125630015672	ABC transporter signature motif; other site
1125630015673	Walker B; other site
1125630015674	D-loop; other site
1125630015675	H-loop/switch region; other site
1125630015676	Hok/gef family; Region: HOK_GEF; cl11494
1125630015677	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
1125630015678	Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092
1125630015679	DALR anticodon binding domain; Region: DALR_1; pfam05746
1125630015680	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
1125630015681	dimer interface [polypeptide binding]; other site
1125630015682	motif 1; other site
1125630015683	active site
1125630015684	motif 2; other site
1125630015685	motif 3; other site
1125630015686	YsaB-like lipoprotein; Region: YsaB; pfam13983
1125630015687	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
1125630015688	hypothetical protein; Provisional; Region: PRK11383
1125630015689	yiaA/B two helix domain; Region: YiaAB; pfam05360
1125630015690	yiaA/B two helix domain; Region: YiaAB; pfam05360
1125630015691	hypothetical protein; Provisional; Region: PRK11403
1125630015692	yiaA/B two helix domain; Region: YiaAB; cl01759
1125630015693	xylulokinase; Provisional; Region: PRK15027
1125630015694	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
1125630015695	N- and C-terminal domain interface [polypeptide binding]; other site
1125630015696	active site
1125630015697	MgATP binding site [chemical binding]; other site
1125630015698	catalytic site [active]
1125630015699	metal binding site [ion binding]; metal-binding site
1125630015700	xylulose binding site [chemical binding]; other site
1125630015701	homodimer interface [polypeptide binding]; other site
1125630015702	xylose isomerase; Provisional; Region: PRK05474
1125630015703	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
1125630015704	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
1125630015705	putative ligand binding site [chemical binding]; other site
1125630015706	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
1125630015707	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1125630015708	Walker A/P-loop; other site
1125630015709	ATP binding site [chemical binding]; other site
1125630015710	Q-loop/lid; other site
1125630015711	ABC transporter signature motif; other site
1125630015712	Walker B; other site
1125630015713	D-loop; other site
1125630015714	H-loop/switch region; other site
1125630015715	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1125630015716	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1125630015717	TM-ABC transporter signature motif; other site
1125630015718	Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543
1125630015719	putative dimerization interface [polypeptide binding]; other site
1125630015720	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1125630015721	putative ligand binding site [chemical binding]; other site
1125630015722	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630015723	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1125630015724	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630015725	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
1125630015726	alpha-amylase; Reviewed; Region: malS; PRK09505
1125630015727	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
1125630015728	active site
1125630015729	catalytic site [active]
1125630015730	valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440
1125630015731	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1125630015732	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630015733	homodimer interface [polypeptide binding]; other site
1125630015734	catalytic residue [active]
1125630015735	formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330
1125630015736	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
1125630015737	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
1125630015738	selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512
1125630015739	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
1125630015740	G1 box; other site
1125630015741	putative GEF interaction site [polypeptide binding]; other site
1125630015742	GTP/Mg2+ binding site [chemical binding]; other site
1125630015743	Switch I region; other site
1125630015744	G2 box; other site
1125630015745	G3 box; other site
1125630015746	Switch II region; other site
1125630015747	G4 box; other site
1125630015748	G5 box; other site
1125630015749	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
1125630015750	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
1125630015751	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
1125630015752	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
1125630015753	selenocysteine synthase; Provisional; Region: PRK04311
1125630015754	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
1125630015755	L-seryl-tRNA selenium transferase; Region: SelA; pfam03841
1125630015756	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1125630015757	catalytic residue [active]
1125630015758	putative glutathione S-transferase; Provisional; Region: PRK10357
1125630015759	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
1125630015760	putative C-terminal domain interface [polypeptide binding]; other site
1125630015761	putative GSH binding site (G-site) [chemical binding]; other site
1125630015762	putative dimer interface [polypeptide binding]; other site
1125630015763	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
1125630015764	dimer interface [polypeptide binding]; other site
1125630015765	N-terminal domain interface [polypeptide binding]; other site
1125630015766	putative substrate binding pocket (H-site) [chemical binding]; other site
1125630015767	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
1125630015768	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1125630015769	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
1125630015770	HlyD family secretion protein; Region: HlyD_3; pfam13437
1125630015771	Protein of unknown function (DUF3302); Region: DUF3302; pfam11742
1125630015772	Chorismate mutase type II; Region: CM_2; cl00693
1125630015773	PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083
1125630015774	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
1125630015775	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
1125630015776	active site
1125630015777	P-loop; other site
1125630015778	phosphorylation site [posttranslational modification]
1125630015779	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1125630015780	active site
1125630015781	phosphorylation site [posttranslational modification]
1125630015782	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
1125630015783	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1125630015784	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1125630015785	mannitol repressor protein; Provisional; Region: mtlR; PRK11001
1125630015786	Glycogen synthesis protein; Region: GlgS; cl11663
1125630015787	hypothetical protein; Provisional; Region: PRK11020
1125630015788	L-lactate permease; Provisional; Region: PRK10420
1125630015789	DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421
1125630015790	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1125630015791	DNA-binding site [nucleotide binding]; DNA binding site
1125630015792	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1125630015793	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
1125630015794	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
1125630015795	active site
1125630015796	substrate binding site [chemical binding]; other site
1125630015797	FMN binding site [chemical binding]; other site
1125630015798	putative catalytic residues [active]
1125630015799	putative rRNA methylase; Provisional; Region: PRK10358
1125630015800	serine acetyltransferase; Provisional; Region: cysE; PRK11132
1125630015801	Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971
1125630015802	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1125630015803	trimer interface [polypeptide binding]; other site
1125630015804	active site
1125630015805	substrate binding site [chemical binding]; other site
1125630015806	CoA binding site [chemical binding]; other site
1125630015807	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1125630015808	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1125630015809	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1125630015810	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557
1125630015811	SecA binding site; other site
1125630015812	Preprotein binding site; other site
1125630015813	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
1125630015814	GSH binding site [chemical binding]; other site
1125630015815	catalytic residues [active]
1125630015816	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1125630015817	active site residue [active]
1125630015818	phosphoglyceromutase; Provisional; Region: PRK05434
1125630015819	AmiB activator; Provisional; Region: PRK11637
1125630015820	Vps51/Vps67; Region: Vps51; pfam08700
1125630015821	Peptidase family M23; Region: Peptidase_M23; pfam01551
1125630015822	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
1125630015823	NodB motif; other site
1125630015824	putative active site [active]
1125630015825	putative catalytic site [active]
1125630015826	Zn binding site [ion binding]; other site
1125630015827	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
1125630015828	putative metal binding site; other site
1125630015829	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
1125630015830	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1125630015831	NAD(P) binding site [chemical binding]; other site
1125630015832	8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858
1125630015833	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
1125630015834	substrate-cofactor binding pocket; other site
1125630015835	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1125630015836	catalytic residue [active]
1125630015837	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
1125630015838	ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150
1125630015839	NADP binding site [chemical binding]; other site
1125630015840	homopentamer interface [polypeptide binding]; other site
1125630015841	substrate binding site [chemical binding]; other site
1125630015842	active site
1125630015843	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1125630015844	putative active site [active]
1125630015845	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1125630015846	putative active site [active]
1125630015847	lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822
1125630015848	O-Antigen ligase; Region: Wzy_C; pfam04932
1125630015849	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1125630015850	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
1125630015851	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1125630015852	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1125630015853	Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935
1125630015854	putative active site [active]
1125630015855	putative catalytic site [active]
1125630015856	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1125630015857	putative active site [active]
1125630015858	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1125630015859	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1125630015860	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1125630015861	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
1125630015862	putative ADP-binding pocket [chemical binding]; other site
1125630015863	putative glycosyl transferase; Provisional; Region: PRK10073
1125630015864	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1125630015865	active site
1125630015866	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
1125630015867	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
1125630015868	Glycosyl transferases group 1; Region: Glycos_transf_1; cl19138
1125630015869	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1125630015870	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
1125630015871	putative metal binding site; other site
1125630015872	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1125630015873	active site
1125630015874	(T/H)XGH motif; other site
1125630015875	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
1125630015876	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1125630015877	DNA binding site [nucleotide binding]
1125630015878	catalytic residue [active]
1125630015879	H2TH interface [polypeptide binding]; other site
1125630015880	putative catalytic residues [active]
1125630015881	turnover-facilitating residue; other site
1125630015882	intercalation triad [nucleotide binding]; other site
1125630015883	8OG recognition residue [nucleotide binding]; other site
1125630015884	putative reading head residues; other site
1125630015885	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1125630015886	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1125630015887	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
1125630015888	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1125630015889	hypothetical protein; Reviewed; Region: PRK00024
1125630015890	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
1125630015891	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1125630015892	MPN+ (JAMM) motif; other site
1125630015893	Zinc-binding site [ion binding]; other site
1125630015894	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
1125630015895	Flavoprotein; Region: Flavoprotein; cl19190
1125630015896	DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127
1125630015897	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1125630015898	trimer interface [polypeptide binding]; other site
1125630015899	active site
1125630015900	division inhibitor protein; Provisional; Region: slmA; PRK09480
1125630015901	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1125630015902	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1125630015903	active site
1125630015904	ribonuclease PH; Reviewed; Region: rph; PRK00173
1125630015905	Ribonuclease PH; Region: RNase_PH_bact; cd11362
1125630015906	hexamer interface [polypeptide binding]; other site
1125630015907	active site
1125630015908	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580
1125630015909	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1125630015910	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1125630015911	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1125630015912	Walker B; other site
1125630015913	D-loop; other site
1125630015914	H-loop/switch region; other site
1125630015915	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
1125630015916	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1125630015917	Walker A/P-loop; other site
1125630015918	ATP binding site [chemical binding]; other site
1125630015919	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
1125630015920	HlyD family secretion protein; Region: HlyD_3; pfam13437
1125630015921	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986
1125630015922	putative acyl-acceptor binding pocket; other site
1125630015923	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
1125630015924	hypothetical protein; Provisional; Region: PRK11820
1125630015925	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
1125630015926	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
1125630015927	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1125630015928	tetramer interface [polypeptide binding]; other site
1125630015929	active site
1125630015930	Mg2+/Mn2+ binding site [ion binding]; other site
1125630015931	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
1125630015932	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
1125630015933	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
1125630015934	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1125630015935	DNA binding site [nucleotide binding]
1125630015936	active site
1125630015937	Putative ClC chloride channel.  Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033
1125630015938	putative ion selectivity filter; other site
1125630015939	putative pore gating glutamate residue; other site
1125630015940	Predicted membrane protein [Function unknown]; Region: COG2860
1125630015941	UPF0126 domain; Region: UPF0126; pfam03458
1125630015942	UPF0126 domain; Region: UPF0126; pfam03458
1125630015943	NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097
1125630015944	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295
1125630015945	nucleotide binding pocket [chemical binding]; other site
1125630015946	K-X-D-G motif; other site
1125630015947	catalytic site [active]
1125630015948	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1125630015949	Phage integrase protein; Region: DUF3701; pfam12482
1125630015950	Guanylate kinase; Region: Guanylate_kin; pfam00625
1125630015951	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1125630015952	catalytic site [active]
1125630015953	G-X2-G-X-G-K; other site
1125630015954	DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690
1125630015955	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
1125630015956	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1125630015957	Zn2+ binding site [ion binding]; other site
1125630015958	Mg2+ binding site [ion binding]; other site
1125630015959	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1125630015960	synthetase active site [active]
1125630015961	NTP binding site [chemical binding]; other site
1125630015962	metal binding site [ion binding]; metal-binding site
1125630015963	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1125630015964	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1125630015965	tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081
1125630015966	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1125630015967	SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105
1125630015968	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
1125630015969	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1125630015970	generic binding surface II; other site
1125630015971	ssDNA binding site; other site
1125630015972	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1125630015973	ATP binding site [chemical binding]; other site
1125630015974	putative Mg++ binding site [ion binding]; other site
1125630015975	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1125630015976	nucleotide binding region [chemical binding]; other site
1125630015977	ATP-binding site [chemical binding]; other site
1125630015978	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
1125630015979	putative active site [active]
1125630015980	ferredoxin-NADP reductase; Provisional; Region: PRK10926
1125630015981	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
1125630015982	FAD binding pocket [chemical binding]; other site
1125630015983	FAD binding motif [chemical binding]; other site
1125630015984	phosphate binding motif [ion binding]; other site
1125630015985	beta-alpha-beta structure motif; other site
1125630015986	NAD binding pocket [chemical binding]; other site
1125630015987	Predicted membrane protein [Function unknown]; Region: COG3152
1125630015988	Protein of unknown function (DUF1454); Region: DUF1454; pfam07305
1125630015989	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1125630015990	substrate binding site [chemical binding]; other site
1125630015991	dimer interface [polypeptide binding]; other site
1125630015992	catalytic triad [active]
1125630015993	anion transporter; Region: dass; TIGR00785
1125630015994	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1125630015995	transmembrane helices; other site
1125630015996	CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471
1125630015997	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1125630015998	substrate binding pocket [chemical binding]; other site
1125630015999	membrane-bound complex binding site; other site
1125630016000	septal ring assembly protein ZapB; Provisional; Region: PRK15422
1125630016001	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
1125630016002	amphipathic channel; other site
1125630016003	Asn-Pro-Ala signature motifs; other site
1125630016004	glycerol kinase; Provisional; Region: glpK; PRK00047
1125630016005	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
1125630016006	N- and C-terminal domain interface [polypeptide binding]; other site
1125630016007	active site
1125630016008	MgATP binding site [chemical binding]; other site
1125630016009	catalytic site [active]
1125630016010	metal binding site [ion binding]; metal-binding site
1125630016011	glycerol binding site [chemical binding]; other site
1125630016012	homotetramer interface [polypeptide binding]; other site
1125630016013	homodimer interface [polypeptide binding]; other site
1125630016014	FBP binding site [chemical binding]; other site
1125630016015	protein IIAGlc interface [polypeptide binding]; other site
1125630016016	Sodium/glutamate symporter; Region: Glt_symporter; cl19414
1125630016017	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
1125630016018	Sulfate transporter family; Region: Sulfate_transp; cl19250
1125630016019	AsmA family; Region: AsmA; pfam05170
1125630016020	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
1125630016021	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1125630016022	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1125630016023	PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005
1125630016024	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1125630016025	active site turn [active]
1125630016026	phosphorylation site [posttranslational modification]
1125630016027	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
1125630016028	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
1125630016029	NAD(P) binding site [chemical binding]; other site
1125630016030	LDH/MDH dimer interface [polypeptide binding]; other site
1125630016031	substrate binding site [chemical binding]; other site
1125630016032	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1125630016033	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1125630016034	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1125630016035	putative active site [active]
1125630016036	putative alpha-glucosidase; Provisional; Region: PRK10658
1125630016037	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
1125630016038	YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593
1125630016039	active site
1125630016040	homotrimer interface [polypeptide binding]; other site
1125630016041	catalytic site [active]
1125630016042	homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site
1125630016043	putative transporter; Provisional; Region: PRK11462
1125630016044	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
1125630016045	Protein of unknown function (DUF3237); Region: DUF3237; pfam11578
1125630016046	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
1125630016047	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
1125630016048	putative NAD(P) binding site [chemical binding]; other site
1125630016049	dimer interface [polypeptide binding]; other site
1125630016050	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1125630016051	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1125630016052	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832
1125630016053	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1125630016054	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
1125630016055	putative NAD(P) binding site [chemical binding]; other site
1125630016056	putative substrate binding site [chemical binding]; other site
1125630016057	catalytic Zn binding site [ion binding]; other site
1125630016058	structural Zn binding site [ion binding]; other site
1125630016059	dimer interface [polypeptide binding]; other site
1125630016060	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
1125630016061	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
1125630016062	conserved cys residue [active]
1125630016063	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630016064	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630016065	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1125630016066	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
1125630016067	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1125630016068	dimer interface [polypeptide binding]; other site
1125630016069	ADP-ribose binding site [chemical binding]; other site
1125630016070	active site
1125630016071	nudix motif; other site
1125630016072	metal binding site [ion binding]; metal-binding site
1125630016073	EamA-like transporter family; Region: EamA; pfam00892
1125630016074	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1125630016075	EamA-like transporter family; Region: EamA; pfam00892
1125630016076	cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861
1125630016077	Cupin; Region: Cupin_6; pfam12852
1125630016078	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630016079	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1125630016080	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1125630016081	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
1125630016082	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1125630016083	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1125630016084	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
1125630016085	basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576
1125630016086	transcriptional regulator; Provisional; Region: PRK10632
1125630016087	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630016088	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471
1125630016089	putative effector binding pocket; other site
1125630016090	putative dimerization interface [polypeptide binding]; other site
1125630016091	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630016092	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1125630016093	putative substrate translocation pore; other site
1125630016094	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1125630016095	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1125630016096	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
1125630016097	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1125630016098	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1125630016099	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1125630016100	HlyD family secretion protein; Region: HlyD_3; pfam13437
1125630016101	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
1125630016102	MMPL family; Region: MMPL; cl14618
1125630016103	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1125630016104	Outer membrane efflux protein; Region: OEP; pfam02321
1125630016105	Outer membrane efflux protein; Region: OEP; pfam02321
1125630016106	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
1125630016107	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630016108	putative substrate translocation pore; other site
1125630016109	N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274
1125630016110	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
1125630016111	putative active site [active]
1125630016112	PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586
1125630016113	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1125630016114	active site turn [active]
1125630016115	phosphorylation site [posttranslational modification]
1125630016116	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1125630016117	EamA-like transporter family; Region: EamA; pfam00892
1125630016118	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1125630016119	EamA-like transporter family; Region: EamA; pfam00892
1125630016120	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1125630016121	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126
1125630016122	Domain of unknown function (DUF1932); Region: DUF1932; pfam09130
1125630016123	PrpF protein; Region: PrpF; cl19418
1125630016124	hypothetical protein; Provisional; Region: PRK09262
1125630016125	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
1125630016126	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630016127	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
1125630016128	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630016129	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1125630016130	dimerization interface [polypeptide binding]; other site
1125630016131	protocatechuate 4,5-dioxygenase; Provisional; Region: PRK13367
1125630016132	The N-terminal domain of the Class III extradiol dioxygenase, Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Region: Gallate_Doxase_N; cd07950
1125630016133	putative active site [active]
1125630016134	Fe(II) binding site [ion binding]; other site
1125630016135	putative dimer interface [polypeptide binding]; other site
1125630016136	The C-terminal domain of Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Region: Gallate_dioxygenase_C; cd07923
1125630016137	putative dimer interface [polypeptide binding]; other site
1125630016138	putative N- and C-terminal domain interface [polypeptide binding]; other site
1125630016139	benzoate transport; Region: 2A0115; TIGR00895
1125630016140	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630016141	putative substrate translocation pore; other site
1125630016142	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1125630016143	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1125630016144	DNA binding site [nucleotide binding]
1125630016145	domain linker motif; other site
1125630016146	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1125630016147	ligand binding site [chemical binding]; other site
1125630016148	dimerization interface [polypeptide binding]; other site
1125630016149	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
1125630016150	active site
1125630016151	P-loop; other site
1125630016152	phosphorylation site [posttranslational modification]
1125630016153	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1125630016154	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
1125630016155	methionine cluster; other site
1125630016156	active site
1125630016157	phosphorylation site [posttranslational modification]
1125630016158	metal binding site [ion binding]; metal-binding site
1125630016159	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1125630016160	maltoporin; Provisional; Region: lamB; PRK09360
1125630016161	potential frameshift: common BLAST hit: gi|238897164|ref|YP_002921912.1| 2-aminoethylphosphonate transport system memrane component
1125630016162	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630016163	putative PBP binding loops; other site
1125630016164	dimer interface [polypeptide binding]; other site
1125630016165	ABC-ATPase subunit interface; other site
1125630016166	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1125630016167	2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050
1125630016168	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630016169	dimer interface [polypeptide binding]; other site
1125630016170	conserved gate region; other site
1125630016171	putative PBP binding loops; other site
1125630016172	ABC-ATPase subunit interface; other site
1125630016173	2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; Region: PhnT; TIGR03258
1125630016174	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1125630016175	Walker A/P-loop; other site
1125630016176	ATP binding site [chemical binding]; other site
1125630016177	Q-loop/lid; other site
1125630016178	ABC transporter signature motif; other site
1125630016179	Walker B; other site
1125630016180	D-loop; other site
1125630016181	H-loop/switch region; other site
1125630016182	TOBE domain; Region: TOBE_2; pfam08402
1125630016183	2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046
1125630016184	2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate binding protein; Region: PhnS; TIGR03227
1125630016185	transcriptional regulator protein; Region: phnR; TIGR03337
1125630016186	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1125630016187	DNA-binding site [nucleotide binding]; DNA binding site
1125630016188	UTRA domain; Region: UTRA; pfam07702
1125630016189	2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479
1125630016190	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1125630016191	catalytic residue [active]
1125630016192	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
1125630016193	phosphonoacetaldehyde hydrolase; Region: phosphonatase; TIGR01422
1125630016194	ribonucleoside transporter; Reviewed; Region: nepI; PRK10213
1125630016195	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630016196	putative substrate translocation pore; other site
1125630016197	Protein of unknown function (DUF1044); Region: DUF1044; pfam06296
1125630016198	Predicted transcriptional regulator [Transcription]; Region: COG2944
1125630016199	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1125630016200	non-specific DNA binding site [nucleotide binding]; other site
1125630016201	salt bridge; other site
1125630016202	sequence-specific DNA binding site [nucleotide binding]; other site
1125630016203	Protein of unknown function (DUF1198); Region: DUF1198; pfam06711
1125630016204	sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556
1125630016205	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630016206	putative substrate translocation pore; other site
1125630016207	regulatory protein UhpC; Provisional; Region: PRK11663
1125630016208	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630016209	putative substrate translocation pore; other site
1125630016210	sensory histidine kinase UhpB; Provisional; Region: PRK11644
1125630016211	MASE1; Region: MASE1; pfam05231
1125630016212	Histidine kinase; Region: HisKA_3; pfam07730
1125630016213	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1125630016214	ATP binding site [chemical binding]; other site
1125630016215	Mg2+ binding site [ion binding]; other site
1125630016216	G-X-G motif; other site
1125630016217	DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360
1125630016218	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1125630016219	active site
1125630016220	phosphorylation site [posttranslational modification]
1125630016221	intermolecular recognition site; other site
1125630016222	dimerization interface [polypeptide binding]; other site
1125630016223	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1125630016224	DNA binding residues [nucleotide binding]
1125630016225	dimerization interface [polypeptide binding]; other site
1125630016226	Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440
1125630016227	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
1125630016228	putative valine binding site [chemical binding]; other site
1125630016229	dimer interface [polypeptide binding]; other site
1125630016230	acetolactate synthase catalytic subunit; Validated; Region: PRK08155
1125630016231	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1125630016232	PYR/PP interface [polypeptide binding]; other site
1125630016233	dimer interface [polypeptide binding]; other site
1125630016234	TPP binding site [chemical binding]; other site
1125630016235	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1125630016236	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1125630016237	TPP-binding site [chemical binding]; other site
1125630016238	dimer interface [polypeptide binding]; other site
1125630016239	Toxin TisB, type I toxin-antitoxin system; Region: TisB_toxin; pfam13939
1125630016240	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1125630016241	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1125630016242	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1125630016243	Coenzyme A binding pocket [chemical binding]; other site
1125630016244	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
1125630016245	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
1125630016246	multidrug resistance protein D; Provisional; Region: emrD; PRK11652
1125630016247	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630016248	putative substrate translocation pore; other site
1125630016249	DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086
1125630016250	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630016251	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1125630016252	dimerization interface [polypeptide binding]; other site
1125630016253	substrate binding pocket [chemical binding]; other site
1125630016254	permease DsdX; Provisional; Region: PRK09921
1125630016255	GntP family permease; Region: GntP_permease; pfam02447
1125630016256	D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine  to pyruvate and ammonia.  D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447
1125630016257	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1125630016258	catalytic residue [active]
1125630016259	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
1125630016260	Nonribosomal peptide synthase; Region: NRPS; pfam08415
1125630016261	Domain of unknown function (DUF202); Region: DUF202; pfam02656
1125630016262	Domain of unknown function (DUF202); Region: DUF202; cl09954
1125630016263	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
1125630016264	Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298
1125630016265	NAD binding site [chemical binding]; other site
1125630016266	sugar binding site [chemical binding]; other site
1125630016267	divalent metal binding site [ion binding]; other site
1125630016268	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
1125630016269	dimer interface [polypeptide binding]; other site
1125630016270	PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005
1125630016271	PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852
1125630016272	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1125630016273	active site turn [active]
1125630016274	phosphorylation site [posttranslational modification]
1125630016275	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1125630016276	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1125630016277	DNA-binding site [nucleotide binding]; DNA binding site
1125630016278	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1125630016279	putative transporter; Validated; Region: PRK03818
1125630016280	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
1125630016281	TrkA-C domain; Region: TrkA_C; pfam02080
1125630016282	TrkA-C domain; Region: TrkA_C; pfam02080
1125630016283	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
1125630016284	DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525
1125630016285	BRO family, N-terminal domain; Region: Bro-N; pfam02498
1125630016286	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1125630016287	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
1125630016288	putative dimer interface [polypeptide binding]; other site
1125630016289	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1125630016290	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
1125630016291	putative dimer interface [polypeptide binding]; other site
1125630016292	hypothetical protein; Provisional; Region: PRK11616
1125630016293	Protein of unknown function (DUF3748); Region: DUF3748; pfam12566
1125630016294	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630016295	D-galactonate transporter; Region: 2A0114; TIGR00893
1125630016296	putative substrate translocation pore; other site
1125630016297	galactonate dehydratase; Provisional; Region: PRK14017
1125630016298	D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325
1125630016299	putative active site pocket [active]
1125630016300	putative metal binding site [ion binding]; other site
1125630016301	Entner-Doudoroff aldolase; Region: eda; TIGR01182
1125630016302	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
1125630016303	active site
1125630016304	intersubunit interface [polypeptide binding]; other site
1125630016305	catalytic residue [active]
1125630016306	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
1125630016307	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1125630016308	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1125630016309	DNA-binding site [nucleotide binding]; DNA binding site
1125630016310	FCD domain; Region: FCD; pfam07729
1125630016311	Surface antigen; Region: Bac_surface_Ag; pfam01103
1125630016312	sugar phosphate phosphatase; Provisional; Region: PRK10513
1125630016313	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1125630016314	active site
1125630016315	motif I; other site
1125630016316	motif II; other site
1125630016317	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
1125630016318	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1125630016319	ATP binding site [chemical binding]; other site
1125630016320	Mg2+ binding site [ion binding]; other site
1125630016321	G-X-G motif; other site
1125630016322	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1125630016323	anchoring element; other site
1125630016324	dimer interface [polypeptide binding]; other site
1125630016325	ATP binding site [chemical binding]; other site
1125630016326	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1125630016327	active site
1125630016328	putative metal-binding site [ion binding]; other site
1125630016329	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1125630016330	recF protein; Region: recf; TIGR00611
1125630016331	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1125630016332	Walker A/P-loop; other site
1125630016333	ATP binding site [chemical binding]; other site
1125630016334	Q-loop/lid; other site
1125630016335	ABC transporter signature motif; other site
1125630016336	Walker B; other site
1125630016337	D-loop; other site
1125630016338	H-loop/switch region; other site
1125630016339	DNA polymerase III subunit beta; Validated; Region: PRK05643
1125630016340	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1125630016341	putative DNA binding surface [nucleotide binding]; other site
1125630016342	dimer interface [polypeptide binding]; other site
1125630016343	beta-clamp/clamp loader binding surface; other site
1125630016344	beta-clamp/translesion DNA polymerase binding surface; other site
1125630016345	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
1125630016346	DnaA N-terminal domain; Region: DnaA_N; pfam11638
1125630016347	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1125630016348	Walker A motif; other site
1125630016349	ATP binding site [chemical binding]; other site
1125630016350	Walker B motif; other site
1125630016351	arginine finger; other site
1125630016352	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1125630016353	DnaA box-binding interface [nucleotide binding]; other site
1125630016354	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
1125630016355	Ribonuclease P; Region: Ribonuclease_P; cl00457
1125630016356	membrane protein insertase; Provisional; Region: PRK01318
1125630016357	YidC periplasmic domain; Region: YidC_periplas; pfam14849
1125630016358	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
1125630016359	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
1125630016360	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
1125630016361	trmE is a tRNA modification GTPase; Region: trmE; cd04164
1125630016362	G1 box; other site
1125630016363	GTP/Mg2+ binding site [chemical binding]; other site
1125630016364	Switch I region; other site
1125630016365	G2 box; other site
1125630016366	Switch II region; other site
1125630016367	G3 box; other site
1125630016368	G4 box; other site
1125630016369	G5 box; other site
1125630016370	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
1125630016371	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1125630016372	Coenzyme A binding pocket [chemical binding]; other site
1125630016373	multidrug efflux system protein MdtL; Provisional; Region: PRK10473
1125630016374	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1125630016375	putative substrate translocation pore; other site
1125630016376	DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216
1125630016377	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1125630016378	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
1125630016379	substrate binding pocket [chemical binding]; other site
1125630016380	dimerization interface [polypeptide binding]; other site
1125630016381	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
1125630016382	Predicted flavoprotein [General function prediction only]; Region: COG0431
1125630016383	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1125630016384	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
1125630016385	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1125630016386	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
1125630016387	active site
1125630016388	motif I; other site
1125630016389	motif II; other site
1125630016390	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
1125630016391	active site
1125630016392	trimer interface [polypeptide binding]; other site
1125630016393	allosteric site; other site
1125630016394	active site lid [active]
1125630016395	hexamer (dimer of trimers) interface [polypeptide binding]; other site
1125630016396	potential frameshift: common BLAST hit: gi|238897226|ref|YP_002921974.1| putative xylanase
1125630016397	Putative esterase; Region: Esterase; pfam00756
1125630016398	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187
1125630016399	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
1125630016400	Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471
1125630016401	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
1125630016402	maltoporin; Provisional; Region: lamB; PRK09360
1125630016403	trimer interface; other site
1125630016404	sugar binding site [chemical binding]; other site
1125630016405	transcriptional regulator PhoU; Provisional; Region: PRK11115
1125630016406	PhoU domain; Region: PhoU; pfam01895
1125630016407	PhoU domain; Region: PhoU; pfam01895
1125630016408	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
1125630016409	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1125630016410	Walker A/P-loop; other site
1125630016411	ATP binding site [chemical binding]; other site
1125630016412	Q-loop/lid; other site
1125630016413	ABC transporter signature motif; other site
1125630016414	Walker B; other site
1125630016415	D-loop; other site
1125630016416	H-loop/switch region; other site
1125630016417	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
1125630016418	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630016419	dimer interface [polypeptide binding]; other site
1125630016420	conserved gate region; other site
1125630016421	putative PBP binding loops; other site
1125630016422	ABC-ATPase subunit interface; other site
1125630016423	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
1125630016424	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1125630016425	dimer interface [polypeptide binding]; other site
1125630016426	conserved gate region; other site
1125630016427	putative PBP binding loops; other site
1125630016428	ABC-ATPase subunit interface; other site
1125630016429	phosphate ABC transporter periplasmic substrate-binding protein PstS; Provisional; Region: PRK10918
1125630016430	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1125630016431	substrate binding pocket [chemical binding]; other site
1125630016432	membrane-bound complex binding site; other site
1125630016433	hinge residues; other site
1125630016434	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1125630016435	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1125630016436	glutaminase active site [active]
1125630016437	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1125630016438	dimer interface [polypeptide binding]; other site
1125630016439	active site
1125630016440	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1125630016441	dimer interface [polypeptide binding]; other site
1125630016442	active site
1125630016443	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451
1125630016444	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1125630016445	Substrate binding site; other site
1125630016446	Mg++ binding site; other site
1125630016447	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1125630016448	active site
1125630016449	substrate binding site [chemical binding]; other site
1125630016450	CoA binding site [chemical binding]; other site
1125630016451	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
1125630016452	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1125630016453	gamma subunit interface [polypeptide binding]; other site
1125630016454	epsilon subunit interface [polypeptide binding]; other site
1125630016455	LBP interface [polypeptide binding]; other site
1125630016456	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1125630016457	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1125630016458	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1125630016459	alpha subunit interaction interface [polypeptide binding]; other site
1125630016460	Walker A motif; other site
1125630016461	ATP binding site [chemical binding]; other site
1125630016462	Walker B motif; other site
1125630016463	inhibitor binding site; inhibition site
1125630016464	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1125630016465	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1125630016466	core domain interface [polypeptide binding]; other site
1125630016467	delta subunit interface [polypeptide binding]; other site
1125630016468	epsilon subunit interface [polypeptide binding]; other site
1125630016469	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1125630016470	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1125630016471	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1125630016472	beta subunit interaction interface [polypeptide binding]; other site
1125630016473	Walker A motif; other site
1125630016474	ATP binding site [chemical binding]; other site
1125630016475	Walker B motif; other site
1125630016476	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1125630016477	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
1125630016478	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
1125630016479	F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192
1125630016480	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
1125630016481	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1125630016482	F0F1 ATP synthase subunit I; Validated; Region: PRK08049
1125630016483	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
1125630016484	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1125630016485	S-adenosylmethionine binding site [chemical binding]; other site
1125630016486	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
1125630016487	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
1125630016488	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
1125630016489	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
1125630016490	Phage integrase family; Region: Phage_integrase; pfam00589
1125630016491	active site
1125630016492	DNA binding site [nucleotide binding]
1125630016493	Int/Topo IB signature motif; other site
1125630016494	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
1125630016495	bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Provisional; Region: PRK13982
1125630016496	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
1125630016497	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
1125630016498	oligomeric interface; other site
1125630016499	putative active site [active]
1125630016500	homodimer interface [polypeptide binding]; other site
1125630016501	AAA ATPase domain; Region: AAA_15; pfam13175
1125630016502	AAA domain; Region: AAA_23; pfam13476
1125630016503	Walker A/P-loop; other site
1125630016504	ATP binding site [chemical binding]; other site
1125630016505	AAA domain; Region: AAA_21; pfam13304
1125630016506	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
1125630016507	putative active site [active]
1125630016508	putative metal-binding site [ion binding]; other site
1125630016509	Viral (Superfamily 1) RNA helicase; Region: Viral_helicase1; pfam01443
1125630016510	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402
1125630016511	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
1125630016512	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
1125630016513	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
1125630016514	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
1125630016515	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
1125630016516	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1125630016517	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1125630016518	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1125630016519	putative transcriptional regulator MerR; Provisional; Region: PRK13752
1125630016520	Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783
1125630016521	DNA binding residues [nucleotide binding]
1125630016522	dimer interface [polypeptide binding]; other site
1125630016523	mercury binding site [ion binding]; other site
1125630016524	putative mercuric transport protein; Provisional; Region: PRK13751
1125630016525	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1125630016526	metal-binding site [ion binding]
1125630016527	putative mercury transport protein MerC; Provisional; Region: PRK13755
1125630016528	putative mercuric reductase; Provisional; Region: PRK14727
1125630016529	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1125630016530	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1125630016531	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
1125630016532	transcriptional regulator MerD; Provisional; Region: PRK13749
1125630016533	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1125630016534	DNA binding residues [nucleotide binding]
1125630016535	putative mercury resistance protein; Provisional; Region: PRK13747
1125630016536	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1125630016537	Homeodomain-like domain; Region: HTH_23; pfam13384
1125630016538	Integrase core domain; Region: rve; pfam00665
1125630016539	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
1125630016540	Transposase; Region: HTH_Tnp_1; cl17663
1125630016541	Integrase core domain; Region: rve; pfam00665
1125630016542	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1125630016543	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1125630016544	Presynaptic Site I dimer interface [polypeptide binding]; other site
1125630016545	catalytic residues [active]
1125630016546	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1125630016547	Synaptic Flat tetramer interface [polypeptide binding]; other site
1125630016548	Synaptic Site I dimer interface [polypeptide binding]; other site
1125630016549	DNA binding site [nucleotide binding]
1125630016550	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393
1125630016551	putative transposase OrfB; Reviewed; Region: PHA02517
1125630016552	Integrase core domain; Region: rve; pfam00665
1125630016553	Integrase core domain; Region: rve_3; pfam13683
1125630016554	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191
1125630016555	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1125630016556	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1125630016557	Antirestriction protein; Region: Antirestrict; pfam03230
1125630016558	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1125630016559	multiple promoter invertase; Provisional; Region: mpi; PRK13413
1125630016560	catalytic residues [active]
1125630016561	catalytic nucleophile [active]
1125630016562	Presynaptic Site I dimer interface [polypeptide binding]; other site
1125630016563	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1125630016564	Synaptic Flat tetramer interface [polypeptide binding]; other site
1125630016565	Synaptic Site I dimer interface [polypeptide binding]; other site
1125630016566	DNA binding site [nucleotide binding]
1125630016567	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569
1125630016568	DNA-binding interface [nucleotide binding]; DNA binding site
1125630016569	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
1125630016570	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
1125630016571	DDE domain; Region: DDE_Tnp_IS240; pfam13610
1125630016572	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1125630016573	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1125630016574	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1125630016575	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1125630016576	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
1125630016577	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1125630016578	replication protein; Provisional; Region: PRK13750
1125630016579	replication protein; Provisional; Region: PRK13702
1125630016580	Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170
1125630016581	PLD-like domain; Region: PLDc_2; pfam13091
1125630016582	putative active site [active]
1125630016583	catalytic site [active]
1125630016584	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
1125630016585	Transposase; Region: HTH_Tnp_1; cl17663
1125630016586	Integrase core domain; Region: rve; pfam00665
1125630016587	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1125630016588	Resolvase, N terminal domain; Region: Resolvase; pfam00239
1125630016589	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393
1125630016590	beta-lactamase TEM; Provisional; Region: PRK15442
1125630016591	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
1125630016592	conjugal transfer fertility inhibition protein FinO; Provisional; Region: PRK13754
1125630016593	Fertility inhibition protein N terminal; Region: FinO_N; pfam12602
1125630016594	ProQ/FINO family; Region: ProQ; pfam04352
1125630016595	putative RNA binding sites [nucleotide binding]; other site
1125630016596	TraX protein; Region: TraX; cl05434
1125630016597	conjugal transfer nickase/helicase TraI; Provisional; Region: PRK13709
1125630016598	TrwC relaxase; Region: TrwC; cl19905
1125630016599	AAA domain; Region: AAA_30; pfam13604
1125630016600	DNA helicase TraI; Region: TraI; pfam07057
1125630016601	conjugal transfer protein TraD; Provisional; Region: PRK13700
1125630016602	F sex factor protein N terminal; Region: TraD_N; pfam12615
1125630016603	Bacterial conjugation protein TrwB,  ATP binding domain. TrwB is a homohexamer encoded by conjugative plasmids in Gram-negative bacteria. TrwB also has an all alpha domain which has been hypothesized to be responsible for DNA binding. TrwB is a component...; Region: TrwB; cd01127
1125630016604	multimer interface [polypeptide binding]; other site
1125630016605	Walker A motif; other site
1125630016606	ATP binding site [chemical binding]; other site
1125630016607	Walker B motif; other site
1125630016608	conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731
1125630016609	conjugal transfer entry exclusion protein TraS; Provisional; Region: PRK13741
1125630016610	conjugal transfer mating pair stabilization protein TraG; Provisional; Region: PRK13735
1125630016611	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
1125630016612	conjugal transfer pilus assembly protein TraH; Provisional; Region: PRK13723
1125630016613	conjugal transfer protein TrbF; Provisional; Region: PRK13743
1125630016614	conjugal transfer protein TrbB; Provisional; Region: PRK13728
1125630016615	conjugal transfer pilin chaperone TraQ; Provisional; Region: PRK13727
1125630016616	conjugal pilus assembly protein TraF; Provisional; Region: PRK13703
1125630016617	conjugal transfer protein TrbE; Provisional; Region: PRK13718
1125630016618	conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355
1125630016619	Type-1V conjugative transfer system mating pair stabilisation; Region: TraN; cl19475
1125630016620	conjugal transfer pilus assembly protein TrbC; Provisional; Region: PRK13730
1125630016621	conjugal transfer pilus assembly protein TraU; Provisional; Region: PRK13737
1125630016622	CASP C terminal; Region: CASP_C; pfam08172
1125630016623	conjugal transfer pilus assembly protein TraW; Provisional; Region: PRK13738
1125630016624	Type-F conjugative transfer system protein (TrbI_Ftype); Region: TrbI_Ftype; pfam09677
1125630016625	conjugal transfer ATP-binding protein TraC; Provisional; Region: PRK13721
1125630016626	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
1125630016627	conjugal transfer protein TraV; Provisional; Region: PRK13733
1125630016628	conjugal transfer pilus assembly protein TraB; Provisional; Region: PRK13729
1125630016629	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
1125630016630	conjugal transfer protein TraK; Provisional; Region: PRK13736
1125630016631	conjugal transfer pilus assembly protein TraE; Provisional; Region: PRK13726
1125630016632	conjugal transfer pilus assembly protein TraL; Provisional; Region: PRK13707
1125630016633	conjugal transfer pilin subunit TraA; Provisional; Region: PRK13734
1125630016634	TraY domain; Region: TraY; pfam05509
1125630016635	conjugal transfer transcriptional regulator TraJ; Provisional; Region: PRK13719
1125630016636	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
1125630016637	conjugal transfer protein TraM; Provisional; Region: PRK13713
1125630016638	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1125630016639	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1125630016640	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1125630016641	catalytic residue [active]
1125630016642	Domain of unknown function (DUF932); Region: DUF932; pfam06067
1125630016643	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1125630016644	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1125630016645	non-specific DNA binding site [nucleotide binding]; other site
1125630016646	salt bridge; other site
1125630016647	sequence-specific DNA binding site [nucleotide binding]; other site
1125630016648	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
1125630016649	small toxic polypeptide; Provisional; Region: PRK09738
1125630016650	PsiA protein; Region: PsiA; pfam06952
1125630016651	Plasmid SOS inhibition protein (PsiB); Region: PsiB; pfam06290
1125630016652	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
1125630016653	ParB-like nuclease domain; Region: ParBc; pfam02195
1125630016654	Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006
1125630016655	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1125630016656	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1125630016657	dimer interface [polypeptide binding]; other site
1125630016658	ssDNA binding site [nucleotide binding]; other site
1125630016659	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1125630016660	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1125630016661	S-adenosylmethionine binding site [chemical binding]; other site
1125630016662	Domain of unknown function (DUF3560); Region: DUF3560; pfam12083
1125630016663	DNA polymerase III, theta subunit; Region: DNA_pol3_theta; cl11635
1125630016664	Antirestriction protein (ArdA); Region: ArdA; pfam07275
1125630016665	Protein of unknown function (DUF1472); Region: DUF1472; pfam07339
1125630016666	Antirestriction protein; Region: Antirestrict; pfam03230
1125630016667	Protein of unknown function (DUF1380); Region: DUF1380; pfam07128
1125630016668	putative methylase; Provisional; Region: PRK13699
1125630016669	Plasmid stability protein; Region: Plasmid_stab_B; pfam10784
1125630016670	Plasmid stability protein; Region: Plasmid_stab_B; pfam10784
1125630016671	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
1125630016672	Mg binding site [ion binding]; other site
1125630016673	nucleotide binding site [chemical binding]; other site
1125630016674	putative protofilament interface [polypeptide binding]; other site
1125630016675	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1125630016676	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1125630016677	putative active site [active]
1125630016678	putative NTP binding site [chemical binding]; other site
1125630016679	putative nucleic acid binding site [nucleotide binding]; other site
1125630016680	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1125630016681	Catalytic site [active]
1125630016682	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
1125630016683	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
1125630016684	active site
1125630016685	DNA binding site [nucleotide binding]
1125630016686	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
1125630016687	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
1125630016688	ParB-like nuclease domain; Region: ParBc; pfam02195
1125630016689	ParB family; Region: ParB; pfam08775
1125630016690	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1125630016691	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1125630016692	P-loop; other site
1125630016693	Magnesium ion binding site [ion binding]; other site
1125630016694	Initiator Replication protein; Region: Rep_3; pfam01051
1125630016695	Helix-turn-helix domain; Region: HTH_17; pfam12728
1125630016696	Rop protein; Region: Rop; pfam01815