-- dump date   	20140619_121416
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1049565000001	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1049565000002	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1049565000003	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1049565000004	Coenzyme A binding pocket [chemical binding]; other site
1049565000005	homoserine O-succinyltransferase; Provisional; Region: PRK05368
1049565000006	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
1049565000007	proposed active site lysine [active]
1049565000008	conserved cys residue [active]
1049565000009	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
1049565000010	malate synthase A; Region: malate_syn_A; TIGR01344
1049565000011	active site
1049565000012	isocitrate lyase; Provisional; Region: PRK15063
1049565000013	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1049565000014	tetramer interface [polypeptide binding]; other site
1049565000015	active site
1049565000016	Mg2+/Mn2+ binding site [ion binding]; other site
1049565000017	Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579
1049565000018	bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946
1049565000019	transcriptional repressor IclR; Provisional; Region: PRK11569
1049565000020	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1049565000021	Bacterial transcriptional regulator; Region: IclR; pfam01614
1049565000022	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
1049565000023	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
1049565000024	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
1049565000025	substrate binding pocket [chemical binding]; other site
1049565000026	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
1049565000027	B12 binding site [chemical binding]; other site
1049565000028	cobalt ligand [ion binding]; other site
1049565000029	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
1049565000030	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
1049565000031	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
1049565000032	shikimate 5-dehydrogenase; Reviewed; Region: PRK12550
1049565000033	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1049565000034	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1049565000035	shikimate binding site; other site
1049565000036	NAD(P) binding site [chemical binding]; other site
1049565000037	L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238
1049565000038	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1049565000039	putative NAD(P) binding site [chemical binding]; other site
1049565000040	catalytic Zn binding site [ion binding]; other site
1049565000041	PTS system, mannose/fructose/sorbose family, IID component; Region: EIID-AGA; TIGR00828
1049565000042	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
1049565000043	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
1049565000044	active site
1049565000045	phosphorylation site [posttranslational modification]
1049565000046	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1049565000047	active pocket/dimerization site; other site
1049565000048	active site
1049565000049	phosphorylation site [posttranslational modification]
1049565000050	sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171
1049565000051	classical (c) SDRs; Region: SDR_c; cd05233
1049565000052	NAD(P) binding site [chemical binding]; other site
1049565000053	active site
1049565000054	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1049565000055	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1049565000056	putative DNA binding site [nucleotide binding]; other site
1049565000057	putative Zn2+ binding site [ion binding]; other site
1049565000058	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1049565000059	23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475
1049565000060	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1049565000061	RNA binding surface [nucleotide binding]; other site
1049565000062	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
1049565000063	probable active site [active]
1049565000064	hypothetical protein; Provisional; Region: PRK10515
1049565000065	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
1049565000066	Sodium Bile acid symporter family; Region: SBF; pfam01758
1049565000067	aspartate kinase III; Validated; Region: PRK09084
1049565000068	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
1049565000069	nucleotide binding site [chemical binding]; other site
1049565000070	substrate binding site [chemical binding]; other site
1049565000071	ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932
1049565000072	lysine allosteric regulatory site; other site
1049565000073	dimer interface [polypeptide binding]; other site
1049565000074	ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917
1049565000075	dimer interface [polypeptide binding]; other site
1049565000076	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
1049565000077	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1049565000078	active site
1049565000079	dimer interface [polypeptide binding]; other site
1049565000080	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1049565000081	dimer interface [polypeptide binding]; other site
1049565000082	active site
1049565000083	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
1049565000084	putative trimer interface [polypeptide binding]; other site
1049565000085	putative active site [active]
1049565000086	putative substrate binding site [chemical binding]; other site
1049565000087	putative CoA binding site [chemical binding]; other site
1049565000088	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1049565000089	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1049565000090	homotrimer interaction site [polypeptide binding]; other site
1049565000091	putative active site [active]
1049565000092	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
1049565000093	AzlC protein; Region: AzlC; pfam03591
1049565000094	L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681
1049565000095	phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833
1049565000096	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1049565000097	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565000098	dimer interface [polypeptide binding]; other site
1049565000099	conserved gate region; other site
1049565000100	putative PBP binding loops; other site
1049565000101	ABC-ATPase subunit interface; other site
1049565000102	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565000103	dimer interface [polypeptide binding]; other site
1049565000104	conserved gate region; other site
1049565000105	putative PBP binding loops; other site
1049565000106	ABC-ATPase subunit interface; other site
1049565000107	maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474
1049565000108	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1049565000109	maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000
1049565000110	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1049565000111	Walker A/P-loop; other site
1049565000112	ATP binding site [chemical binding]; other site
1049565000113	Q-loop/lid; other site
1049565000114	ABC transporter signature motif; other site
1049565000115	Walker B; other site
1049565000116	D-loop; other site
1049565000117	H-loop/switch region; other site
1049565000118	TOBE domain; Region: TOBE_2; pfam08402
1049565000119	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
1049565000120	trimer interface; other site
1049565000121	sugar binding site [chemical binding]; other site
1049565000122	maltose regulon periplasmic protein; Provisional; Region: PRK10564
1049565000123	chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655
1049565000124	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
1049565000125	UbiA prenyltransferase family; Region: UbiA; pfam01040
1049565000126	glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703
1049565000127	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
1049565000128	putative acyl-acceptor binding pocket; other site
1049565000129	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
1049565000130	LexA repressor; Validated; Region: PRK00215
1049565000131	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
1049565000132	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1049565000133	Catalytic site [active]
1049565000134	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
1049565000135	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
1049565000136	hypothetical protein; Provisional; Region: PRK10428
1049565000137	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1049565000138	metal binding site 2 [ion binding]; metal-binding site
1049565000139	putative DNA binding helix; other site
1049565000140	metal binding site 1 [ion binding]; metal-binding site
1049565000141	dimer interface [polypeptide binding]; other site
1049565000142	structural Zn2+ binding site [ion binding]; other site
1049565000143	Cupin domain; Region: Cupin_2; cl17218
1049565000144	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
1049565000145	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1049565000146	FMN binding site [chemical binding]; other site
1049565000147	active site
1049565000148	catalytic residues [active]
1049565000149	substrate binding site [chemical binding]; other site
1049565000150	phage shock protein G; Reviewed; Region: pspG; PRK09459
1049565000151	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
1049565000152	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
1049565000153	NADP binding site [chemical binding]; other site
1049565000154	dimer interface [polypeptide binding]; other site
1049565000155	replicative DNA helicase; Provisional; Region: PRK08006
1049565000156	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1049565000157	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1049565000158	Walker A motif; other site
1049565000159	ATP binding site [chemical binding]; other site
1049565000160	Walker B motif; other site
1049565000161	DNA binding loops [nucleotide binding]
1049565000162	alanine racemase; Reviewed; Region: alr; PRK00053
1049565000163	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
1049565000164	active site
1049565000165	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1049565000166	substrate binding site [chemical binding]; other site
1049565000167	catalytic residues [active]
1049565000168	dimer interface [polypeptide binding]; other site
1049565000169	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
1049565000170	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1049565000171	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565000172	homodimer interface [polypeptide binding]; other site
1049565000173	catalytic residue [active]
1049565000174	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1049565000175	active site
1049565000176	motif I; other site
1049565000177	motif II; other site
1049565000178	Uncharacterized conserved protein [Function unknown]; Region: COG0432
1049565000179	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
1049565000180	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1049565000181	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1049565000182	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1049565000183	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1049565000184	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1049565000185	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1049565000186	dimer interface [polypeptide binding]; other site
1049565000187	ssDNA binding site [nucleotide binding]; other site
1049565000188	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1049565000189	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
1049565000190	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1049565000191	substrate binding pocket [chemical binding]; other site
1049565000192	membrane-bound complex binding site; other site
1049565000193	hinge residues; other site
1049565000194	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1049565000195	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1049565000196	catalytic residue [active]
1049565000197	outer membrane receptor FepA; Provisional; Region: PRK13524
1049565000198	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1049565000199	N-terminal plug; other site
1049565000200	ligand-binding site [chemical binding]; other site
1049565000201	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565000202	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1049565000203	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565000204	Tannase and feruloyl esterase; Region: Tannase; pfam07519
1049565000205	outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067
1049565000206	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1049565000207	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1049565000208	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1049565000209	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1049565000210	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1049565000211	Surface antigen; Region: Bac_surface_Ag; pfam01103
1049565000212	anti-adapter protein IraM; Provisional; Region: PRK09919
1049565000213	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
1049565000214	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1049565000215	active site
1049565000216	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1049565000217	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402
1049565000218	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278
1049565000219	putative dimerization interface [polypeptide binding]; other site
1049565000220	putative ligand binding site [chemical binding]; other site
1049565000221	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
1049565000222	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1049565000223	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1049565000224	Walker A/P-loop; other site
1049565000225	ATP binding site [chemical binding]; other site
1049565000226	Q-loop/lid; other site
1049565000227	ABC transporter signature motif; other site
1049565000228	Walker B; other site
1049565000229	D-loop; other site
1049565000230	H-loop/switch region; other site
1049565000231	TOBE domain; Region: TOBE_2; pfam08402
1049565000232	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1049565000233	hypothetical protein; Provisional; Region: PRK11622
1049565000234	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565000235	dimer interface [polypeptide binding]; other site
1049565000236	conserved gate region; other site
1049565000237	putative PBP binding loops; other site
1049565000238	ABC-ATPase subunit interface; other site
1049565000239	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1049565000240	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565000241	dimer interface [polypeptide binding]; other site
1049565000242	conserved gate region; other site
1049565000243	putative PBP binding loops; other site
1049565000244	ABC-ATPase subunit interface; other site
1049565000245	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
1049565000246	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
1049565000247	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1049565000248	DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219
1049565000249	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565000250	redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002
1049565000251	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
1049565000252	DNA binding residues [nucleotide binding]
1049565000253	dimer interface [polypeptide binding]; other site
1049565000254	[2Fe-2S] cluster binding site [ion binding]; other site
1049565000255	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1049565000256	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
1049565000257	putative C-terminal domain interface [polypeptide binding]; other site
1049565000258	putative GSH binding site (G-site) [chemical binding]; other site
1049565000259	putative dimer interface [polypeptide binding]; other site
1049565000260	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
1049565000261	putative N-terminal domain interface [polypeptide binding]; other site
1049565000262	putative dimer interface [polypeptide binding]; other site
1049565000263	putative substrate binding pocket (H-site) [chemical binding]; other site
1049565000264	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1049565000265	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
1049565000266	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
1049565000267	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565000268	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565000269	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
1049565000270	putative dimerization interface [polypeptide binding]; other site
1049565000271	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
1049565000272	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
1049565000273	Fimbrial protein; Region: Fimbrial; cl01416
1049565000274	fimbrial assembly chaperone SthB; Provisional; Region: PRK15295
1049565000275	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
1049565000276	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
1049565000277	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
1049565000278	PapC N-terminal domain; Region: PapC_N; pfam13954
1049565000279	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
1049565000280	PapC C-terminal domain; Region: PapC_C; pfam13953
1049565000281	Fimbrial protein; Region: Fimbrial; cl01416
1049565000282	putative major fimbrial protein SthE; Provisional; Region: PRK15292
1049565000283	Fimbrial protein; Region: Fimbrial; cl01416
1049565000284	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1049565000285	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
1049565000286	Na binding site [ion binding]; other site
1049565000287	Predicted membrane protein [Function unknown]; Region: COG3162
1049565000288	acetyl-CoA synthetase; Provisional; Region: PRK00174
1049565000289	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
1049565000290	active site
1049565000291	CoA binding site [chemical binding]; other site
1049565000292	acyl-activating enzyme (AAE) consensus motif; other site
1049565000293	AMP binding site [chemical binding]; other site
1049565000294	acetate binding site [chemical binding]; other site
1049565000295	glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283
1049565000296	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1049565000297	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1049565000298	potential frameshift: common BLAST hit: gi|238892571|ref|YP_002917305.1| formate dehydrogenase-H
1049565000299	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1049565000300	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1049565000301	active site
1049565000302	phosphorylation site [posttranslational modification]
1049565000303	intermolecular recognition site; other site
1049565000304	dimerization interface [polypeptide binding]; other site
1049565000305	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1049565000306	DNA binding site [nucleotide binding]
1049565000307	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
1049565000308	Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459
1049565000309	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
1049565000310	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
1049565000311	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1049565000312	substrate binding site [chemical binding]; other site
1049565000313	ATP binding site [chemical binding]; other site
1049565000314	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1049565000315	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321
1049565000316	putative ligand binding site [chemical binding]; other site
1049565000317	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1049565000318	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1049565000319	TM-ABC transporter signature motif; other site
1049565000320	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1049565000321	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1049565000322	Walker A/P-loop; other site
1049565000323	ATP binding site [chemical binding]; other site
1049565000324	Q-loop/lid; other site
1049565000325	ABC transporter signature motif; other site
1049565000326	Walker B; other site
1049565000327	D-loop; other site
1049565000328	H-loop/switch region; other site
1049565000329	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1049565000330	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1049565000331	dimerization interface [polypeptide binding]; other site
1049565000332	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1049565000333	dimer interface [polypeptide binding]; other site
1049565000334	phosphorylation site [posttranslational modification]
1049565000335	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1049565000336	ATP binding site [chemical binding]; other site
1049565000337	Mg2+ binding site [ion binding]; other site
1049565000338	G-X-G motif; other site
1049565000339	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1049565000340	active site
1049565000341	phosphorylation site [posttranslational modification]
1049565000342	intermolecular recognition site; other site
1049565000343	putative hydrolase; Provisional; Region: PRK02113
1049565000344	carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244
1049565000345	ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078
1049565000346	active site
1049565000347	phosphonate metabolism protein PhnM; Provisional; Region: PRK15446
1049565000348	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1049565000349	PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306
1049565000350	active site
1049565000351	ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778
1049565000352	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1049565000353	Walker A/P-loop; other site
1049565000354	ATP binding site [chemical binding]; other site
1049565000355	Q-loop/lid; other site
1049565000356	ABC transporter signature motif; other site
1049565000357	Walker B; other site
1049565000358	D-loop; other site
1049565000359	H-loop/switch region; other site
1049565000360	phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701
1049565000361	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1049565000362	Walker A/P-loop; other site
1049565000363	ATP binding site [chemical binding]; other site
1049565000364	Q-loop/lid; other site
1049565000365	ABC transporter signature motif; other site
1049565000366	Walker B; other site
1049565000367	D-loop; other site
1049565000368	H-loop/switch region; other site
1049565000369	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1049565000370	Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627
1049565000371	Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861
1049565000372	carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147
1049565000373	Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754
1049565000374	phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079
1049565000375	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1049565000376	DNA-binding site [nucleotide binding]; DNA binding site
1049565000377	UTRA domain; Region: UTRA; pfam07702
1049565000378	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1049565000379	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1049565000380	dimer interface [polypeptide binding]; other site
1049565000381	hypothetical protein; Provisional; Region: PRK10220
1049565000382	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
1049565000383	PhnA protein; Region: PhnA; pfam03831
1049565000384	proline/glycine betaine transporter; Provisional; Region: PRK10642
1049565000385	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565000386	putative substrate translocation pore; other site
1049565000387	Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946
1049565000388	DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371
1049565000389	Cupin domain; Region: Cupin_2; cl17218
1049565000390	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565000391	alpha-galactosidase; Provisional; Region: PRK15076
1049565000392	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
1049565000393	NAD binding site [chemical binding]; other site
1049565000394	sugar binding site [chemical binding]; other site
1049565000395	divalent metal binding site [ion binding]; other site
1049565000396	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
1049565000397	dimer interface [polypeptide binding]; other site
1049565000398	melibiose:sodium symporter; Provisional; Region: PRK10429
1049565000399	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
1049565000400	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
1049565000401	PRTRC system protein D; Region: PRTRC_D; TIGR03739
1049565000402	Mg binding site [ion binding]; other site
1049565000403	nucleotide binding site [chemical binding]; other site
1049565000404	putative protofilament interface [polypeptide binding]; other site
1049565000405	Plasmid stability protein; Region: Plasmid_stab_B; pfam10784
1049565000406	chaperone-modulator protein CbpM; Provisional; Region: PRK10265
1049565000407	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
1049565000408	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
1049565000409	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1049565000410	HSP70 interaction site [polypeptide binding]; other site
1049565000411	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1049565000412	substrate binding site [polypeptide binding]; other site
1049565000413	dimer interface [polypeptide binding]; other site
1049565000414	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
1049565000415	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
1049565000416	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
1049565000417	catalytic residues [active]
1049565000418	hemin storage system protein; Provisional; Region: hmsS; PRK14584
1049565000419	N-glycosyltransferase; Provisional; Region: PRK11204
1049565000420	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
1049565000421	DXD motif; other site
1049565000422	outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582
1049565000423	N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964
1049565000424	putative active site [active]
1049565000425	putative metal binding site [ion binding]; other site
1049565000426	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
1049565000427	outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049
1049565000428	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
1049565000429	dimerization interface [polypeptide binding]; other site
1049565000430	DNA binding residues [nucleotide binding]
1049565000431	PerC transcriptional activator; Region: PerC; pfam06069
1049565000432	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1049565000433	Helix-turn-helix domain; Region: HTH_28; pfam13518
1049565000434	Helix-turn-helix domain; Region: HTH_28; pfam13518
1049565000435	putative transposase OrfB; Reviewed; Region: PHA02517
1049565000436	HTH-like domain; Region: HTH_21; pfam13276
1049565000437	Integrase core domain; Region: rve; pfam00665
1049565000438	Integrase core domain; Region: rve_2; pfam13333
1049565000439	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
1049565000440	putative transcriptional regulator; Provisional; Region: PRK11640
1049565000441	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
1049565000442	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
1049565000443	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
1049565000444	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
1049565000445	DsbD alpha interface [polypeptide binding]; other site
1049565000446	catalytic residues [active]
1049565000447	divalent-cation tolerance protein CutA; Provisional; Region: PRK10645
1049565000448	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
1049565000449	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
1049565000450	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
1049565000451	Aspartase; Region: Aspartase; cd01357
1049565000452	active sites [active]
1049565000453	tetramer interface [polypeptide binding]; other site
1049565000454	Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030
1049565000455	putative transporter; Provisional; Region: PRK11021
1049565000456	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1049565000457	oligomerisation interface [polypeptide binding]; other site
1049565000458	mobile loop; other site
1049565000459	roof hairpin; other site
1049565000460	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1049565000461	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1049565000462	ring oligomerisation interface [polypeptide binding]; other site
1049565000463	ATP/Mg binding site [chemical binding]; other site
1049565000464	stacking interactions; other site
1049565000465	hinge regions; other site
1049565000466	Domain of unknown function (DUF4156); Region: DUF4156; pfam13698
1049565000467	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
1049565000468	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419
1049565000469	putative active site [active]
1049565000470	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1049565000471	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
1049565000472	Walker A/P-loop; other site
1049565000473	ATP binding site [chemical binding]; other site
1049565000474	Q-loop/lid; other site
1049565000475	ABC transporter signature motif; other site
1049565000476	Walker B; other site
1049565000477	D-loop; other site
1049565000478	H-loop/switch region; other site
1049565000479	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
1049565000480	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1049565000481	HlyD family secretion protein; Region: HlyD_3; pfam13437
1049565000482	Fimbrial protein; Region: Fimbrial; pfam00419
1049565000483	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
1049565000484	PapC N-terminal domain; Region: PapC_N; pfam13954
1049565000485	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
1049565000486	PapC C-terminal domain; Region: PapC_C; pfam13953
1049565000487	fimbrial assembly chaperone SthB; Provisional; Region: PRK15295
1049565000488	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
1049565000489	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
1049565000490	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
1049565000491	DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710
1049565000492	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1049565000493	DNA binding site [nucleotide binding]
1049565000494	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
1049565000495	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1049565000496	FeS/SAM binding site; other site
1049565000497	elongation factor P; Validated; Region: PRK00529
1049565000498	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1049565000499	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1049565000500	RNA binding site [nucleotide binding]; other site
1049565000501	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1049565000502	RNA binding site [nucleotide binding]; other site
1049565000503	Predicted small secreted protein [Function unknown]; Region: COG5510
1049565000504	entericidin B membrane lipoprotein; Provisional; Region: PRK10081
1049565000505	multidrug efflux system protein; Provisional; Region: PRK11431
1049565000506	outer membrane lipoprotein Blc; Provisional; Region: PRK10477
1049565000507	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
1049565000508	Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547
1049565000509	Iron-sulfur protein interface; other site
1049565000510	proximal quinone binding site [chemical binding]; other site
1049565000511	C-subunit interface; other site
1049565000512	distal quinone binding site; other site
1049565000513	Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C;  QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546
1049565000514	D-subunit interface [polypeptide binding]; other site
1049565000515	Iron-sulfur protein interface; other site
1049565000516	proximal quinone binding site [chemical binding]; other site
1049565000517	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385
1049565000518	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1049565000519	fumarate reductase flavoprotein subunit; Validated; Region: PRK09231
1049565000520	L-aspartate oxidase; Provisional; Region: PRK06175
1049565000521	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1049565000522	poxB regulator PoxA; Provisional; Region: PRK09350
1049565000523	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1049565000524	motif 1; other site
1049565000525	dimer interface [polypeptide binding]; other site
1049565000526	active site
1049565000527	motif 2; other site
1049565000528	motif 3; other site
1049565000529	inner membrane transporter YjeM; Provisional; Region: PRK15238
1049565000530	putative mechanosensitive channel protein; Provisional; Region: PRK10929
1049565000531	Protein-interacting V-domain of mammalian Alix and related domains; Region: V_Alix_like; cl14654
1049565000532	putative YPXnL-motif binding site; other site
1049565000533	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
1049565000534	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1049565000535	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
1049565000536	GTPase RsgA; Reviewed; Region: PRK12288
1049565000537	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1049565000538	RNA binding site [nucleotide binding]; other site
1049565000539	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1049565000540	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1049565000541	GTP/Mg2+ binding site [chemical binding]; other site
1049565000542	G4 box; other site
1049565000543	G5 box; other site
1049565000544	G1 box; other site
1049565000545	Switch I region; other site
1049565000546	G2 box; other site
1049565000547	G3 box; other site
1049565000548	Switch II region; other site
1049565000549	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
1049565000550	catalytic site [active]
1049565000551	putative active site [active]
1049565000552	putative substrate binding site [chemical binding]; other site
1049565000553	dimer interface [polypeptide binding]; other site
1049565000554	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1049565000555	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1049565000556	substrate binding pocket [chemical binding]; other site
1049565000557	membrane-bound complex binding site; other site
1049565000558	hinge residues; other site
1049565000559	epoxyqueuosine reductase; Region: TIGR00276
1049565000560	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
1049565000561	putative carbohydrate kinase; Provisional; Region: PRK10565
1049565000562	Uncharacterized conserved protein [Function unknown]; Region: COG0062
1049565000563	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1049565000564	putative substrate binding site [chemical binding]; other site
1049565000565	putative ATP binding site [chemical binding]; other site
1049565000566	ADP-binding protein; Provisional; Region: PRK10646
1049565000567	N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431
1049565000568	AMIN domain; Region: AMIN; pfam11741
1049565000569	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1049565000570	active site
1049565000571	metal binding site [ion binding]; metal-binding site
1049565000572	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
1049565000573	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1049565000574	ATP binding site [chemical binding]; other site
1049565000575	Mg2+ binding site [ion binding]; other site
1049565000576	G-X-G motif; other site
1049565000577	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
1049565000578	ATP binding site [chemical binding]; other site
1049565000579	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
1049565000580	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
1049565000581	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1049565000582	bacterial Hfq-like; Region: Hfq; cd01716
1049565000583	hexamer interface [polypeptide binding]; other site
1049565000584	Sm1 motif; other site
1049565000585	RNA binding site [nucleotide binding]; other site
1049565000586	Sm2 motif; other site
1049565000587	GTPase HflX; Provisional; Region: PRK11058
1049565000588	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1049565000589	HflX GTPase family; Region: HflX; cd01878
1049565000590	G1 box; other site
1049565000591	GTP/Mg2+ binding site [chemical binding]; other site
1049565000592	Switch I region; other site
1049565000593	G2 box; other site
1049565000594	G3 box; other site
1049565000595	Switch II region; other site
1049565000596	G4 box; other site
1049565000597	G5 box; other site
1049565000598	FtsH protease regulator HflK; Provisional; Region: PRK10930
1049565000599	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
1049565000600	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
1049565000601	FtsH protease regulator HflC; Provisional; Region: PRK11029
1049565000602	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
1049565000603	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242
1049565000604	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1049565000605	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1049565000606	GDP-binding site [chemical binding]; other site
1049565000607	ACT binding site; other site
1049565000608	IMP binding site; other site
1049565000609	Predicted transcriptional regulator [Transcription]; Region: COG1959
1049565000610	transcriptional repressor NsrR; Provisional; Region: PRK11014
1049565000611	exoribonuclease R; Provisional; Region: PRK11642
1049565000612	Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461
1049565000613	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
1049565000614	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1049565000615	RNB domain; Region: RNB; pfam00773
1049565000616	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
1049565000617	RNA binding site [nucleotide binding]; other site
1049565000618	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
1049565000619	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
1049565000620	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1049565000621	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
1049565000622	Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154
1049565000623	FAD binding site [chemical binding]; other site
1049565000624	substrate binding site [chemical binding]; other site
1049565000625	catalytic residues [active]
1049565000626	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
1049565000627	putative biofilm stress and motility protein A; Provisional; Region: PRK14864
1049565000628	esterase; Provisional; Region: PRK10566
1049565000629	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1049565000630	transcriptional repressor UlaR; Provisional; Region: PRK13509
1049565000631	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1049565000632	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1049565000633	putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709
1049565000634	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1049565000635	Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037
1049565000636	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
1049565000637	active site
1049565000638	P-loop; other site
1049565000639	phosphorylation site [posttranslational modification]
1049565000640	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1049565000641	active site
1049565000642	phosphorylation site [posttranslational modification]
1049565000643	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
1049565000644	active site
1049565000645	dimer interface [polypeptide binding]; other site
1049565000646	magnesium binding site [ion binding]; other site
1049565000647	L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209
1049565000648	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
1049565000649	AP (apurinic/apyrimidinic) site pocket; other site
1049565000650	DNA interaction; other site
1049565000651	Metal-binding active site; metal-binding site
1049565000652	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
1049565000653	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
1049565000654	intersubunit interface [polypeptide binding]; other site
1049565000655	active site
1049565000656	Zn2+ binding site [ion binding]; other site
1049565000657	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565000658	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1049565000659	putative substrate translocation pore; other site
1049565000660	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
1049565000661	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1049565000662	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1049565000663	dimer interface [polypeptide binding]; other site
1049565000664	ssDNA binding site [nucleotide binding]; other site
1049565000665	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1049565000666	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
1049565000667	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1049565000668	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1049565000669	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1049565000670	Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061
1049565000671	Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525
1049565000672	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
1049565000673	peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570
1049565000674	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
1049565000675	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1049565000676	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
1049565000677	iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992
1049565000678	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
1049565000679	Hemerythrin-like domain; Region: Hr-like; cd12108
1049565000680	Fe binding site [ion binding]; other site
1049565000681	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1049565000682	EamA-like transporter family; Region: EamA; pfam00892
1049565000683	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1049565000684	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1049565000685	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565000686	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565000687	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1049565000688	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
1049565000689	NADP binding site [chemical binding]; other site
1049565000690	Predicted transcriptional regulators [Transcription]; Region: COG1733
1049565000691	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1049565000692	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
1049565000693	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
1049565000694	active site
1049565000695	metal binding site [ion binding]; metal-binding site
1049565000696	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1049565000697	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
1049565000698	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1049565000699	active site
1049565000700	Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; cl17398
1049565000701	Protein of unknown function (DUF1107); Region: DUF1107; pfam06526
1049565000702	DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572
1049565000703	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1049565000704	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565000705	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565000706	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
1049565000707	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
1049565000708	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
1049565000709	galactoside permease; Reviewed; Region: lacY; PRK09528
1049565000710	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1049565000711	Domain of unknown function DUF21; Region: DUF21; pfam01595
1049565000712	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1049565000713	Transporter associated domain; Region: CorC_HlyC; smart01091
1049565000714	methionine sulfoxide reductase A; Provisional; Region: PRK00058
1049565000715	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
1049565000716	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1049565000717	Surface antigen; Region: Bac_surface_Ag; pfam01103
1049565000718	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
1049565000719	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1049565000720	Family of unknown function (DUF490); Region: DUF490; pfam04357
1049565000721	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
1049565000722	putative active site pocket [active]
1049565000723	dimerization interface [polypeptide binding]; other site
1049565000724	putative catalytic residue [active]
1049565000725	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
1049565000726	dimer interface [polypeptide binding]; other site
1049565000727	substrate binding site [chemical binding]; other site
1049565000728	metal binding sites [ion binding]; metal-binding site
1049565000729	Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309
1049565000730	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1049565000731	putative ligand binding site [chemical binding]; other site
1049565000732	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1049565000733	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1049565000734	Walker A/P-loop; other site
1049565000735	ATP binding site [chemical binding]; other site
1049565000736	Q-loop/lid; other site
1049565000737	ABC transporter signature motif; other site
1049565000738	Walker B; other site
1049565000739	D-loop; other site
1049565000740	H-loop/switch region; other site
1049565000741	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1049565000742	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1049565000743	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1049565000744	TM-ABC transporter signature motif; other site
1049565000745	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1049565000746	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1049565000747	TM-ABC transporter signature motif; other site
1049565000748	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
1049565000749	AMP binding site [chemical binding]; other site
1049565000750	metal binding site [ion binding]; metal-binding site
1049565000751	active site
1049565000752	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
1049565000753	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1049565000754	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1049565000755	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1049565000756	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1049565000757	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1049565000758	Coenzyme A binding pocket [chemical binding]; other site
1049565000759	Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023
1049565000760	active site
1049565000761	catalytic residues [active]
1049565000762	hypothetical protein; Provisional; Region: PRK05255
1049565000763	peptidase PmbA; Provisional; Region: PRK11040
1049565000764	Cytochrome b562; Region: Cytochrom_B562; cl01546
1049565000765	PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582
1049565000766	Glycine-rich SFCGS; Region: Gly_rich_SFCGS; cl11916
1049565000767	conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578
1049565000768	conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580
1049565000769	conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579
1049565000770	dihydroorotase; Provisional; Region: PRK09237
1049565000771	Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307
1049565000772	active site
1049565000773	uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437
1049565000774	conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581
1049565000775	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
1049565000776	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1049565000777	HTH domain; Region: HTH_11; pfam08279
1049565000778	Mga helix-turn-helix domain; Region: Mga; pfam05043
1049565000779	PRD domain; Region: PRD; pfam00874
1049565000780	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1049565000781	active site
1049565000782	P-loop; other site
1049565000783	phosphorylation site [posttranslational modification]
1049565000784	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1049565000785	active site
1049565000786	phosphorylation site [posttranslational modification]
1049565000787	bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235
1049565000788	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491
1049565000789	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1049565000790	FeS/SAM binding site; other site
1049565000791	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
1049565000792	ATP cone domain; Region: ATP-cone; pfam03477
1049565000793	Class III ribonucleotide reductase; Region: RNR_III; cd01675
1049565000794	effector binding site; other site
1049565000795	active site
1049565000796	Zn binding site [ion binding]; other site
1049565000797	glycine loop; other site
1049565000798	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1049565000799	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1049565000800	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1049565000801	putative active site [active]
1049565000802	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
1049565000803	active site
1049565000804	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
1049565000805	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
1049565000806	NAD binding site [chemical binding]; other site
1049565000807	sugar binding site [chemical binding]; other site
1049565000808	divalent metal binding site [ion binding]; other site
1049565000809	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1049565000810	dimer interface [polypeptide binding]; other site
1049565000811	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1049565000812	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295
1049565000813	trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933
1049565000814	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1049565000815	Ca binding site [ion binding]; other site
1049565000816	active site
1049565000817	catalytic site [active]
1049565000818	PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007
1049565000819	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1049565000820	active site turn [active]
1049565000821	phosphorylation site [posttranslational modification]
1049565000822	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1049565000823	trehalose repressor; Provisional; Region: treR; PRK09492
1049565000824	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1049565000825	DNA binding site [nucleotide binding]
1049565000826	domain linker motif; other site
1049565000827	Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542
1049565000828	dimerization interface [polypeptide binding]; other site
1049565000829	ligand binding site [chemical binding]; other site
1049565000830	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
1049565000831	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
1049565000832	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1049565000833	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1049565000834	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1049565000835	motif II; other site
1049565000836	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1049565000837	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1049565000838	homotrimer interaction site [polypeptide binding]; other site
1049565000839	putative active site [active]
1049565000840	aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893
1049565000841	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
1049565000842	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
1049565000843	Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540
1049565000844	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1049565000845	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1049565000846	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
1049565000847	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
1049565000848	A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710
1049565000849	putative active site [active]
1049565000850	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1049565000851	dimer interface [polypeptide binding]; other site
1049565000852	active site
1049565000853	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1049565000854	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1049565000855	substrate binding site [chemical binding]; other site
1049565000856	ATP binding site [chemical binding]; other site
1049565000857	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1049565000858	active site
1049565000859	Predicted membrane protein [Function unknown]; Region: COG1288
1049565000860	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
1049565000861	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1049565000862	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1049565000863	DNA-binding site [nucleotide binding]; DNA binding site
1049565000864	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1049565000865	ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515
1049565000866	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1049565000867	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1049565000868	RNase E inhibitor protein; Provisional; Region: PRK11191
1049565000869	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
1049565000870	active site
1049565000871	dinuclear metal binding site [ion binding]; other site
1049565000872	dimerization interface [polypeptide binding]; other site
1049565000873	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1049565000874	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1049565000875	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1049565000876	HIGH motif; other site
1049565000877	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1049565000878	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1049565000879	active site
1049565000880	KMSKS motif; other site
1049565000881	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1049565000882	tRNA binding surface [nucleotide binding]; other site
1049565000883	anticodon binding site; other site
1049565000884	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1049565000885	DNA polymerase III subunit chi; Validated; Region: PRK05728
1049565000886	multifunctional aminopeptidase A; Provisional; Region: PRK00913
1049565000887	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1049565000888	interface (dimer of trimers) [polypeptide binding]; other site
1049565000889	Substrate-binding/catalytic site; other site
1049565000890	Zn-binding sites [ion binding]; other site
1049565000891	lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120
1049565000892	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
1049565000893	lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071
1049565000894	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
1049565000895	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
1049565000896	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1049565000897	Walker A motif; other site
1049565000898	ATP binding site [chemical binding]; other site
1049565000899	Walker B motif; other site
1049565000900	Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130
1049565000901	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
1049565000902	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
1049565000903	tetrameric interface [polypeptide binding]; other site
1049565000904	NAD binding site [chemical binding]; other site
1049565000905	catalytic residues [active]
1049565000906	Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718
1049565000907	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1049565000908	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1049565000909	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1049565000910	putative active site [active]
1049565000911	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1049565000912	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1049565000913	substrate binding site [chemical binding]; other site
1049565000914	ATP binding site [chemical binding]; other site
1049565000915	Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863
1049565000916	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892
1049565000917	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
1049565000918	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1049565000919	PYR/PP interface [polypeptide binding]; other site
1049565000920	dimer interface [polypeptide binding]; other site
1049565000921	TPP binding site [chemical binding]; other site
1049565000922	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1049565000923	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
1049565000924	TPP-binding site; other site
1049565000925	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1049565000926	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1049565000927	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1049565000928	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1049565000929	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1049565000930	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1049565000931	Metal-binding active site; metal-binding site
1049565000932	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1049565000933	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1049565000934	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1049565000935	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1049565000936	Walker A/P-loop; other site
1049565000937	ATP binding site [chemical binding]; other site
1049565000938	Q-loop/lid; other site
1049565000939	ABC transporter signature motif; other site
1049565000940	Walker B; other site
1049565000941	D-loop; other site
1049565000942	H-loop/switch region; other site
1049565000943	TOBE domain; Region: TOBE_2; pfam08402
1049565000944	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
1049565000945	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1049565000946	active site
1049565000947	metal binding site [ion binding]; metal-binding site
1049565000948	hexamer interface [polypeptide binding]; other site
1049565000949	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1049565000950	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565000951	dimer interface [polypeptide binding]; other site
1049565000952	conserved gate region; other site
1049565000953	putative PBP binding loops; other site
1049565000954	ABC-ATPase subunit interface; other site
1049565000955	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565000956	dimer interface [polypeptide binding]; other site
1049565000957	conserved gate region; other site
1049565000958	putative PBP binding loops; other site
1049565000959	ABC-ATPase subunit interface; other site
1049565000960	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1049565000961	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
1049565000962	putative NAD(P) binding site [chemical binding]; other site
1049565000963	putative substrate binding site [chemical binding]; other site
1049565000964	catalytic Zn binding site [ion binding]; other site
1049565000965	structural Zn binding site [ion binding]; other site
1049565000966	dimer interface [polypeptide binding]; other site
1049565000967	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1049565000968	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1049565000969	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1049565000970	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1049565000971	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1049565000972	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
1049565000973	active site clefts [active]
1049565000974	zinc binding site [ion binding]; other site
1049565000975	dimer interface [polypeptide binding]; other site
1049565000976	potential protein location (hypothetical protein KPN2242_01525 [Klebsiella pneumoniae KCTC 2242]) that overlaps RNA (tRNA-L)
1049565000977	integrase; Provisional; Region: PRK09692
1049565000978	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
1049565000979	active site
1049565000980	Int/Topo IB signature motif; other site
1049565000981	Protein kinase domain; Region: Pkinase; pfam00069
1049565000982	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1049565000983	active site
1049565000984	ATP binding site [chemical binding]; other site
1049565000985	substrate binding site [chemical binding]; other site
1049565000986	activation loop (A-loop); other site
1049565000987	HerA helicase [Replication, recombination, and repair]; Region: COG0433
1049565000988	Domain of unknown function DUF87; Region: DUF87; pfam01935
1049565000989	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1049565000990	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1049565000991	McrBC 5-methylcytosine restriction system component; Region: McrBC; pfam10117
1049565000992	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
1049565000993	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1049565000994	Transposase; Region: HTH_Tnp_1; pfam01527
1049565000995	putative transposase OrfB; Reviewed; Region: PHA02517
1049565000996	HTH-like domain; Region: HTH_21; pfam13276
1049565000997	Integrase core domain; Region: rve; pfam00665
1049565000998	Integrase core domain; Region: rve_2; pfam13333
1049565000999	Domain of unknown function (DUF4400); Region: DUF4400; cl14023
1049565001000	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
1049565001001	Transposase; Region: HTH_Tnp_1; pfam01527
1049565001002	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1049565001003	Integrase core domain; Region: rve_3; pfam13683
1049565001004	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1049565001005	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1049565001006	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1049565001007	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1049565001008	active site
1049565001009	Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039
1049565001010	potential frameshift: common BLAST hit: gi|332161527|ref|YP_004298104.1| putative transposase
1049565001011	MULE transposase domain; Region: MULE; pfam10551
1049565001012	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
1049565001013	glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173
1049565001014	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
1049565001015	catalytic core [active]
1049565001016	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
1049565001017	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1049565001018	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1049565001019	trimer interface [polypeptide binding]; other site
1049565001020	eyelet of channel; other site
1049565001021	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1049565001022	putative active site [active]
1049565001023	Protein of unknown function (DUF2857); Region: DUF2857; pfam11198
1049565001024	integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764
1049565001025	ParB-like nuclease domain; Region: ParBc; pfam02195
1049565001026	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134
1049565001027	hypothetical protein; Provisional; Region: PRK11622
1049565001028	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1049565001029	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565001030	dimer interface [polypeptide binding]; other site
1049565001031	conserved gate region; other site
1049565001032	putative PBP binding loops; other site
1049565001033	ABC-ATPase subunit interface; other site
1049565001034	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565001035	dimer interface [polypeptide binding]; other site
1049565001036	conserved gate region; other site
1049565001037	putative PBP binding loops; other site
1049565001038	ABC-ATPase subunit interface; other site
1049565001039	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1049565001040	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1049565001041	Walker A/P-loop; other site
1049565001042	ATP binding site [chemical binding]; other site
1049565001043	Q-loop/lid; other site
1049565001044	ABC transporter signature motif; other site
1049565001045	Walker B; other site
1049565001046	D-loop; other site
1049565001047	H-loop/switch region; other site
1049565001048	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1049565001049	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
1049565001050	active site
1049565001051	catalytic site [active]
1049565001052	MarR family; Region: MarR_2; pfam12802
1049565001053	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1049565001054	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1049565001055	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
1049565001056	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
1049565001057	inhibitor binding site; inhibition site
1049565001058	active site
1049565001059	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
1049565001060	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
1049565001061	xylose isomerase; Provisional; Region: PRK05474
1049565001062	xylose isomerase; Region: xylose_isom_A; TIGR02630
1049565001063	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1049565001064	Protein of unknown function (DUF523); Region: DUF523; pfam04463
1049565001065	Uncharacterized conserved protein [Function unknown]; Region: COG3272
1049565001066	Protein of unknown function (DUF1722); Region: DUF1722; cl01284
1049565001067	Protein of unknown function (DUF3833); Region: DUF3833; pfam12915
1049565001068	Protein of unknown function (DUF2878); Region: DUF2878; pfam11086
1049565001069	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
1049565001070	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1049565001071	S-adenosylmethionine binding site [chemical binding]; other site
1049565001072	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
1049565001073	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
1049565001074	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1049565001075	short chain dehydrogenase; Provisional; Region: PRK06101
1049565001076	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1049565001077	NAD(P) binding site [chemical binding]; other site
1049565001078	active site
1049565001079	SnoaL-like domain; Region: SnoaL_2; pfam12680
1049565001080	transcriptional regulator MirA; Provisional; Region: PRK15043
1049565001081	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
1049565001082	DNA binding residues [nucleotide binding]
1049565001083	outer membrane lipoprotein Blc; Provisional; Region: PRK10477
1049565001084	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
1049565001085	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
1049565001086	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
1049565001087	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
1049565001088	HlyD family secretion protein; Region: HlyD_3; pfam13437
1049565001089	Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363
1049565001090	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
1049565001091	DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836
1049565001092	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1049565001093	active site
1049565001094	phosphorylation site [posttranslational modification]
1049565001095	intermolecular recognition site; other site
1049565001096	dimerization interface [polypeptide binding]; other site
1049565001097	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1049565001098	DNA binding site [nucleotide binding]
1049565001099	sensor kinase CusS; Provisional; Region: PRK09835
1049565001100	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1049565001101	dimerization interface [polypeptide binding]; other site
1049565001102	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1049565001103	dimer interface [polypeptide binding]; other site
1049565001104	phosphorylation site [posttranslational modification]
1049565001105	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1049565001106	ATP binding site [chemical binding]; other site
1049565001107	Mg2+ binding site [ion binding]; other site
1049565001108	G-X-G motif; other site
1049565001109	Protein of unknown function (DUF1778); Region: DUF1778; pfam08681
1049565001110	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1049565001111	Uncharacterized conserved protein [Function unknown]; Region: COG2850
1049565001112	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1049565001113	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1049565001114	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1049565001115	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1049565001116	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1049565001117	Walker A/P-loop; other site
1049565001118	ATP binding site [chemical binding]; other site
1049565001119	Q-loop/lid; other site
1049565001120	ABC transporter signature motif; other site
1049565001121	Walker B; other site
1049565001122	D-loop; other site
1049565001123	H-loop/switch region; other site
1049565001124	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1049565001125	Walker A/P-loop; other site
1049565001126	ATP binding site [chemical binding]; other site
1049565001127	Q-loop/lid; other site
1049565001128	ABC transporter signature motif; other site
1049565001129	Walker B; other site
1049565001130	D-loop; other site
1049565001131	H-loop/switch region; other site
1049565001132	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1049565001133	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
1049565001134	HlyD family secretion protein; Region: HlyD; pfam00529
1049565001135	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1049565001136	HlyD family secretion protein; Region: HlyD_3; pfam13437
1049565001137	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1049565001138	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1049565001139	active site
1049565001140	HIGH motif; other site
1049565001141	dimer interface [polypeptide binding]; other site
1049565001142	KMSKS motif; other site
1049565001143	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
1049565001144	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1049565001145	ligand binding site [chemical binding]; other site
1049565001146	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1049565001147	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1049565001148	Walker A/P-loop; other site
1049565001149	ATP binding site [chemical binding]; other site
1049565001150	Q-loop/lid; other site
1049565001151	ABC transporter signature motif; other site
1049565001152	Walker B; other site
1049565001153	D-loop; other site
1049565001154	H-loop/switch region; other site
1049565001155	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1049565001156	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1049565001157	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1049565001158	TM-ABC transporter signature motif; other site
1049565001159	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1049565001160	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1049565001161	TM-ABC transporter signature motif; other site
1049565001162	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
1049565001163	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1049565001164	potential frameshift: common BLAST hit: gi|152973225|ref|YP_001338371.1| transcriptional regulator LysR
1049565001165	fosfomycin resistance protein FosB; Provisional; Region: PRK04101
1049565001166	FosA, a Fosfomycin resistance protein, catalyzes the addition of glutathione to the antibiotic fosfomycin, making it inactive; Region: FosA; cd07244
1049565001167	dimer interface [polypeptide binding]; other site
1049565001168	Mn binding site [ion binding]; other site
1049565001169	K binding site [ion binding]; other site
1049565001170	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1049565001171	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1049565001172	DNA-binding site [nucleotide binding]; DNA binding site
1049565001173	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1049565001174	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565001175	homodimer interface [polypeptide binding]; other site
1049565001176	catalytic residue [active]
1049565001177	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
1049565001178	transcriptional regulator SlyA; Provisional; Region: PRK03573
1049565001179	MarR family; Region: MarR_2; cl17246
1049565001180	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
1049565001181	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1049565001182	Protein of unknown function (DUF2955); Region: DUF2955; pfam11168
1049565001183	Protein of unknown function (DUF3343); Region: DUF3343; pfam11823
1049565001184	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
1049565001185	CoA-substrate-specific enzyme activase, putative; Region: CoA_E_activ; TIGR00241
1049565001186	Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775
1049565001187	benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263
1049565001188	Uncharacterized conserved protein (DUF2164); Region: DUF2164; cl02278
1049565001189	multidrug efflux system protein MdtM; Provisional; Region: PRK15403
1049565001190	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565001191	putative substrate translocation pore; other site
1049565001192	Protein of unknown function (DUF445); Region: DUF445; pfam04286
1049565001193	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1049565001194	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1049565001195	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1049565001196	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565001197	putative transposase; Provisional; Region: PRK09857
1049565001198	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
1049565001199	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
1049565001200	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
1049565001201	NAD(P) binding site [chemical binding]; other site
1049565001202	catalytic residues [active]
1049565001203	YfaZ precursor; Region: YfaZ; pfam07437
1049565001204	putative GTP-binding protein YjiA; Provisional; Region: PRK11537
1049565001205	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
1049565001206	P-loop, Walker A motif; other site
1049565001207	Base recognition motif; other site
1049565001208	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1049565001209	Uncharacterized small protein [Function unknown]; Region: COG2879
1049565001210	carbon starvation protein A; Provisional; Region: PRK15015
1049565001211	Carbon starvation protein CstA; Region: CstA; pfam02554
1049565001212	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
1049565001213	4-hydroxyphenylacetate 3-monooxygenase reductase subunit; Provisional; Region: hpaC; PRK15486
1049565001214	4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310
1049565001215	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
1049565001216	4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297
1049565001217	Cupin domain; Region: Cupin_2; pfam07883
1049565001218	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565001219	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
1049565001220	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565001221	putative substrate translocation pore; other site
1049565001222	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
1049565001223	2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312
1049565001224	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
1049565001225	putative substrate binding pocket [chemical binding]; other site
1049565001226	trimer interface [polypeptide binding]; other site
1049565001227	The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370
1049565001228	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
1049565001229	putative active site [active]
1049565001230	putative metal binding site [ion binding]; other site
1049565001231	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299
1049565001232	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
1049565001233	NAD binding site [chemical binding]; other site
1049565001234	catalytic residues [active]
1049565001235	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1049565001236	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
1049565001237	homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337
1049565001238	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1049565001239	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
1049565001240	potential frameshift: common BLAST hit: gi|218550368|ref|YP_002384159.1| aldolase or racemase
1049565001241	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
1049565001242	D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
1049565001243	active site
1049565001244	putative substrate binding pocket [chemical binding]; other site
1049565001245	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1049565001246	homotrimer interaction site [polypeptide binding]; other site
1049565001247	putative active site [active]
1049565001248	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
1049565001249	Na binding site [ion binding]; other site
1049565001250	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
1049565001251	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
1049565001252	2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140
1049565001253	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
1049565001254	active site
1049565001255	intersubunit interface [polypeptide binding]; other site
1049565001256	catalytic residue [active]
1049565001257	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1049565001258	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1049565001259	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1049565001260	putative active site [active]
1049565001261	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1049565001262	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1049565001263	Coenzyme A binding pocket [chemical binding]; other site
1049565001264	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1049565001265	Integrase core domain; Region: rve; pfam00665
1049565001266	Integrase core domain; Region: rve_3; pfam13683
1049565001267	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1049565001268	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
1049565001269	Coenzyme A binding pocket [chemical binding]; other site
1049565001270	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
1049565001271	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1049565001272	Walker A motif; other site
1049565001273	ATP binding site [chemical binding]; other site
1049565001274	Walker B motif; other site
1049565001275	arginine finger; other site
1049565001276	Transcriptional antiterminator [Transcription]; Region: COG3933
1049565001277	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1049565001278	active pocket/dimerization site; other site
1049565001279	active site
1049565001280	phosphorylation site [posttranslational modification]
1049565001281	PRD domain; Region: PRD; pfam00874
1049565001282	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1049565001283	active pocket/dimerization site; other site
1049565001284	active site
1049565001285	phosphorylation site [posttranslational modification]
1049565001286	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
1049565001287	active site
1049565001288	phosphorylation site [posttranslational modification]
1049565001289	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
1049565001290	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
1049565001291	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
1049565001292	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1049565001293	dimer interface [polypeptide binding]; other site
1049565001294	active site
1049565001295	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1049565001296	dimer interface [polypeptide binding]; other site
1049565001297	active site
1049565001298	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
1049565001299	A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710
1049565001300	putative active site [active]
1049565001301	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
1049565001302	putative transposase; Provisional; Region: PRK09857
1049565001303	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
1049565001304	phosphoglycerol transferase I; Provisional; Region: PRK03776
1049565001305	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1049565001306	hypothetical protein; Provisional; Region: PRK11667
1049565001307	DNA replication protein DnaC; Validated; Region: PRK07952
1049565001308	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1049565001309	Walker A motif; other site
1049565001310	ATP binding site [chemical binding]; other site
1049565001311	Walker B motif; other site
1049565001312	primosomal protein DnaI; Provisional; Region: PRK02854
1049565001313	hypothetical protein; Provisional; Region: PRK09917
1049565001314	Uncharacterized conserved protein [Function unknown]; Region: COG2966
1049565001315	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
1049565001316	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
1049565001317	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1049565001318	4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297
1049565001319	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565001320	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1049565001321	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1049565001322	DNA binding residues [nucleotide binding]
1049565001323	dimerization interface [polypeptide binding]; other site
1049565001324	DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475
1049565001325	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1049565001326	DNA binding residues [nucleotide binding]
1049565001327	dimerization interface [polypeptide binding]; other site
1049565001328	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
1049565001329	putative deacylase active site [active]
1049565001330	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1049565001331	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1049565001332	ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647
1049565001333	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1049565001334	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
1049565001335	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1049565001336	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1049565001337	metal binding site [ion binding]; metal-binding site
1049565001338	active site
1049565001339	I-site; other site
1049565001340	Protein of unknown function (DUF1435); Region: DUF1435; pfam07256
1049565001341	16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489
1049565001342	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
1049565001343	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1049565001344	DNA polymerase III subunit psi; Validated; Region: PRK06856
1049565001345	ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491
1049565001346	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1049565001347	Coenzyme A binding pocket [chemical binding]; other site
1049565001348	dUMP phosphatase; Provisional; Region: PRK09449
1049565001349	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1049565001350	motif II; other site
1049565001351	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
1049565001352	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
1049565001353	G1 box; other site
1049565001354	putative GEF interaction site [polypeptide binding]; other site
1049565001355	GTP/Mg2+ binding site [chemical binding]; other site
1049565001356	Switch I region; other site
1049565001357	G2 box; other site
1049565001358	G3 box; other site
1049565001359	Switch II region; other site
1049565001360	G4 box; other site
1049565001361	G5 box; other site
1049565001362	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
1049565001363	BON domain; Region: BON; pfam04972
1049565001364	BON domain; Region: BON; cl02771
1049565001365	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
1049565001366	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
1049565001367	active site
1049565001368	nucleophile elbow; other site
1049565001369	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1049565001370	active site
1049565001371	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1049565001372	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1049565001373	Nucleoside recognition; Region: Gate; pfam07670
1049565001374	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1049565001375	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1049565001376	intersubunit interface [polypeptide binding]; other site
1049565001377	active site
1049565001378	catalytic residue [active]
1049565001379	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
1049565001380	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1049565001381	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1049565001382	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
1049565001383	phosphopentomutase; Provisional; Region: PRK05362
1049565001384	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
1049565001385	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
1049565001386	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
1049565001387	lipoate-protein ligase A; Provisional; Region: lplA; PRK03822
1049565001388	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1049565001389	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
1049565001390	hypothetical protein; Provisional; Region: PRK11246
1049565001391	phosphoserine phosphatase; Provisional; Region: serB; PRK11133
1049565001392	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1049565001393	motif II; other site
1049565001394	DNA repair protein RadA; Region: sms; TIGR00416
1049565001395	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
1049565001396	Walker A motif/ATP binding site; other site
1049565001397	ATP binding site [chemical binding]; other site
1049565001398	Walker B motif; other site
1049565001399	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1049565001400	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1049565001401	non-specific DNA binding site [nucleotide binding]; other site
1049565001402	salt bridge; other site
1049565001403	bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099
1049565001404	sequence-specific DNA binding site [nucleotide binding]; other site
1049565001405	Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167
1049565001406	active site
1049565001407	(T/H)XGH motif; other site
1049565001408	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
1049565001409	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
1049565001410	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1049565001411	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1049565001412	ABC transporter; Region: ABC_tran_2; pfam12848
1049565001413	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1049565001414	lytic murein transglycosylase; Provisional; Region: PRK11619
1049565001415	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1049565001416	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1049565001417	catalytic residue [active]
1049565001418	Trp operon repressor; Provisional; Region: PRK01381
1049565001419	inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074
1049565001420	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1049565001421	catalytic core [active]
1049565001422	right oriC-binding transcriptional activator; Provisional; Region: PRK15121
1049565001423	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565001424	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
1049565001425	hypothetical protein; Provisional; Region: PRK10756
1049565001426	CreA protein; Region: CreA; pfam05981
1049565001427	DNA-binding response regulator CreB; Provisional; Region: PRK11083
1049565001428	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1049565001429	active site
1049565001430	phosphorylation site [posttranslational modification]
1049565001431	intermolecular recognition site; other site
1049565001432	dimerization interface [polypeptide binding]; other site
1049565001433	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1049565001434	DNA binding site [nucleotide binding]
1049565001435	sensory histidine kinase CreC; Provisional; Region: PRK11100
1049565001436	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1049565001437	dimer interface [polypeptide binding]; other site
1049565001438	phosphorylation site [posttranslational modification]
1049565001439	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1049565001440	ATP binding site [chemical binding]; other site
1049565001441	Mg2+ binding site [ion binding]; other site
1049565001442	G-X-G motif; other site
1049565001443	Inner membrane protein CreD; Region: CreD; pfam06123
1049565001444	two-component response regulator; Provisional; Region: PRK11173
1049565001445	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1049565001446	active site
1049565001447	phosphorylation site [posttranslational modification]
1049565001448	intermolecular recognition site; other site
1049565001449	dimerization interface [polypeptide binding]; other site
1049565001450	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1049565001451	DNA binding site [nucleotide binding]
1049565001452	putative RNA methyltransferase; Provisional; Region: PRK10433
1049565001453	RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050
1049565001454	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
1049565001455	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
1049565001456	putative catalytic residues [active]
1049565001457	putative nucleotide binding site [chemical binding]; other site
1049565001458	putative aspartate binding site [chemical binding]; other site
1049565001459	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
1049565001460	dimer interface [polypeptide binding]; other site
1049565001461	putative threonine allosteric regulatory site; other site
1049565001462	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
1049565001463	putative threonine allosteric regulatory site; other site
1049565001464	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1049565001465	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1049565001466	homoserine kinase; Provisional; Region: PRK01212
1049565001467	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1049565001468	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1049565001469	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
1049565001470	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
1049565001471	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565001472	catalytic residue [active]
1049565001473	hypothetical protein; Validated; Region: PRK02101
1049565001474	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
1049565001475	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1049565001476	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1049565001477	Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235
1049565001478	transaldolase-like protein; Provisional; Region: PTZ00411
1049565001479	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
1049565001480	active site
1049565001481	dimer interface [polypeptide binding]; other site
1049565001482	catalytic residue [active]
1049565001483	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1049565001484	MPT binding site; other site
1049565001485	trimer interface [polypeptide binding]; other site
1049565001486	metabolite-proton symporter; Region: 2A0106; TIGR00883
1049565001487	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565001488	putative substrate translocation pore; other site
1049565001489	hypothetical protein; Provisional; Region: PRK10659
1049565001490	hypothetical protein; Provisional; Region: PRK10236
1049565001491	Domain of unknown function (DUF3944); Region: DUF3944; pfam13099
1049565001492	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735
1049565001493	Protein of unknown function (DUF2541); Region: DUF2541; pfam10807
1049565001494	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1049565001495	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1049565001496	nucleotide binding site [chemical binding]; other site
1049565001497	chaperone protein DnaJ; Provisional; Region: PRK10767
1049565001498	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1049565001499	HSP70 interaction site [polypeptide binding]; other site
1049565001500	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
1049565001501	substrate binding site [polypeptide binding]; other site
1049565001502	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1049565001503	Zn binding sites [ion binding]; other site
1049565001504	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1049565001505	dimer interface [polypeptide binding]; other site
1049565001506	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561
1049565001507	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
1049565001508	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565001509	The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429
1049565001510	putative dimerization interface [polypeptide binding]; other site
1049565001511	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
1049565001512	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
1049565001513	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1049565001514	active site
1049565001515	Riboflavin kinase; Region: Flavokinase; smart00904
1049565001516	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
1049565001517	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1049565001518	HIGH motif; other site
1049565001519	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1049565001520	active site
1049565001521	KMSKS motif; other site
1049565001522	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
1049565001523	tRNA binding surface [nucleotide binding]; other site
1049565001524	anticodon binding site; other site
1049565001525	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1049565001526	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
1049565001527	lipoprotein signal peptidase; Provisional; Region: PRK14787
1049565001528	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
1049565001529	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1049565001530	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
1049565001531	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
1049565001532	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
1049565001533	active site
1049565001534	tetramer interface [polypeptide binding]; other site
1049565001535	Protein of unknown function (DUF805); Region: DUF805; pfam05656
1049565001536	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565001537	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565001538	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1049565001539	putative effector binding pocket; other site
1049565001540	dimerization interface [polypeptide binding]; other site
1049565001541	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
1049565001542	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
1049565001543	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1049565001544	active site
1049565001545	phosphorylation site [posttranslational modification]
1049565001546	intermolecular recognition site; other site
1049565001547	dimerization interface [polypeptide binding]; other site
1049565001548	Transcriptional regulator; Region: CitT; pfam12431
1049565001549	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
1049565001550	PAS domain; Region: PAS; smart00091
1049565001551	putative active site [active]
1049565001552	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1049565001553	ATP binding site [chemical binding]; other site
1049565001554	Mg2+ binding site [ion binding]; other site
1049565001555	G-X-G motif; other site
1049565001556	oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476
1049565001557	oxaloacetate decarboxylase; Provisional; Region: PRK14040
1049565001558	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
1049565001559	active site
1049565001560	catalytic residues [active]
1049565001561	metal binding site [ion binding]; metal-binding site
1049565001562	homodimer binding site [polypeptide binding]; other site
1049565001563	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1049565001564	carboxyltransferase (CT) interaction site; other site
1049565001565	biotinylation site [posttranslational modification]; other site
1049565001566	oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919
1049565001567	Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493
1049565001568	[citrate (pro-3S)-lyase] ligase; Region: cit_ly_ligase; TIGR00124
1049565001569	Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169
1049565001570	putative active site [active]
1049565001571	(T/H)XGH motif; other site
1049565001572	citrate lyase acyl carrier protein; Region: citD; TIGR01608
1049565001573	citrate lyase, beta subunit; Region: citE; TIGR01588
1049565001574	Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051
1049565001575	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
1049565001576	triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125
1049565001577	Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289
1049565001578	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1049565001579	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1049565001580	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1049565001581	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
1049565001582	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1049565001583	catalytic site [active]
1049565001584	subunit interface [polypeptide binding]; other site
1049565001585	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1049565001586	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1049565001587	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1049565001588	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1049565001589	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1049565001590	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1049565001591	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1049565001592	IMP binding site; other site
1049565001593	dimer interface [polypeptide binding]; other site
1049565001594	interdomain contacts; other site
1049565001595	partial ornithine binding site; other site
1049565001596	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
1049565001597	glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871
1049565001598	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
1049565001599	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
1049565001600	TrkA-N domain; Region: TrkA_N; pfam02254
1049565001601	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1049565001602	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1049565001603	folate binding site [chemical binding]; other site
1049565001604	NADP+ binding site [chemical binding]; other site
1049565001605	bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668
1049565001606	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
1049565001607	active site
1049565001608	metal binding site [ion binding]; metal-binding site
1049565001609	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
1049565001610	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1049565001611	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
1049565001612	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
1049565001613	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
1049565001614	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
1049565001615	SurA N-terminal domain; Region: SurA_N; pfam09312
1049565001616	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1049565001617	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1049565001618	LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761
1049565001619	OstA-like protein; Region: OstA; pfam03968
1049565001620	Organic solvent tolerance protein; Region: OstA_C; pfam04453
1049565001621	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
1049565001622	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
1049565001623	putative metal binding site [ion binding]; other site
1049565001624	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1049565001625	HSP70 interaction site [polypeptide binding]; other site
1049565001626	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
1049565001627	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1049565001628	active site
1049565001629	phosphorylation site [posttranslational modification]
1049565001630	intermolecular recognition site; other site
1049565001631	dimerization interface [polypeptide binding]; other site
1049565001632	Transcriptional regulator; Region: CitT; pfam12431
1049565001633	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1049565001634	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
1049565001635	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1049565001636	putative active site [active]
1049565001637	heme pocket [chemical binding]; other site
1049565001638	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1049565001639	ATP binding site [chemical binding]; other site
1049565001640	Mg2+ binding site [ion binding]; other site
1049565001641	G-X-G motif; other site
1049565001642	2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390
1049565001643	holo-ACP synthase CitX; Region: citrate_citX; TIGR03124
1049565001644	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1049565001645	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1049565001646	active site
1049565001647	ATP-dependent helicase HepA; Validated; Region: PRK04914
1049565001648	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1049565001649	ATP binding site [chemical binding]; other site
1049565001650	putative Mg++ binding site [ion binding]; other site
1049565001651	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1049565001652	nucleotide binding region [chemical binding]; other site
1049565001653	ATP-binding site [chemical binding]; other site
1049565001654	DNA polymerase II; Reviewed; Region: PRK05762
1049565001655	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784
1049565001656	active site
1049565001657	catalytic site [active]
1049565001658	substrate binding site [chemical binding]; other site
1049565001659	DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537
1049565001660	active site
1049565001661	metal-binding site
1049565001662	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
1049565001663	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
1049565001664	intersubunit interface [polypeptide binding]; other site
1049565001665	active site
1049565001666	Zn2+ binding site [ion binding]; other site
1049565001667	L-arabinose isomerase; Provisional; Region: PRK02929
1049565001668	L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557
1049565001669	putative hexamer (dimer of trimers) interface [polypeptide binding]; other site
1049565001670	trimer interface [polypeptide binding]; other site
1049565001671	putative substrate binding site [chemical binding]; other site
1049565001672	putative metal binding site [ion binding]; other site
1049565001673	ribulokinase; Provisional; Region: PRK04123
1049565001674	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
1049565001675	N- and C-terminal domain interface [polypeptide binding]; other site
1049565001676	active site
1049565001677	MgATP binding site [chemical binding]; other site
1049565001678	catalytic site [active]
1049565001679	metal binding site [ion binding]; metal-binding site
1049565001680	carbohydrate binding site [chemical binding]; other site
1049565001681	homodimer interface [polypeptide binding]; other site
1049565001682	DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572
1049565001683	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1049565001684	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565001685	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565001686	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1049565001687	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1049565001688	thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771
1049565001689	ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298
1049565001690	Walker A/P-loop; other site
1049565001691	ATP binding site [chemical binding]; other site
1049565001692	Q-loop/lid; other site
1049565001693	ABC transporter signature motif; other site
1049565001694	Walker B; other site
1049565001695	D-loop; other site
1049565001696	H-loop/switch region; other site
1049565001697	thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433
1049565001698	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565001699	dimer interface [polypeptide binding]; other site
1049565001700	conserved gate region; other site
1049565001701	putative PBP binding loops; other site
1049565001702	ABC-ATPase subunit interface; other site
1049565001703	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565001704	dimer interface [polypeptide binding]; other site
1049565001705	conserved gate region; other site
1049565001706	putative PBP binding loops; other site
1049565001707	ABC-ATPase subunit interface; other site
1049565001708	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
1049565001709	thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205
1049565001710	transcriptional regulator SgrR; Provisional; Region: PRK13626
1049565001711	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
1049565001712	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
1049565001713	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565001714	sugar efflux transporter; Region: 2A0120; TIGR00899
1049565001715	putative substrate translocation pore; other site
1049565001716	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565001717	D-galactonate transporter; Region: 2A0114; TIGR00893
1049565001718	putative substrate translocation pore; other site
1049565001719	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565001720	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565001721	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
1049565001722	putative dimerization interface [polypeptide binding]; other site
1049565001723	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
1049565001724	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
1049565001725	active site
1049565001726	catalytic residue [active]
1049565001727	dimer interface [polypeptide binding]; other site
1049565001728	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565001729	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1049565001730	putative substrate translocation pore; other site
1049565001731	shikimate 5-dehydrogenase; Provisional; Region: PRK12548
1049565001732	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1049565001733	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1049565001734	shikimate binding site; other site
1049565001735	NAD(P) binding site [chemical binding]; other site
1049565001736	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1049565001737	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
1049565001738	active site
1049565001739	FMN binding site [chemical binding]; other site
1049565001740	substrate binding site [chemical binding]; other site
1049565001741	putative catalytic residue [active]
1049565001742	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1049565001743	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1049565001744	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
1049565001745	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1049565001746	substrate binding site [chemical binding]; other site
1049565001747	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
1049565001748	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1049565001749	substrate binding site [chemical binding]; other site
1049565001750	ligand binding site [chemical binding]; other site
1049565001751	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
1049565001752	tartrate dehydrogenase; Region: TTC; TIGR02089
1049565001753	2-isopropylmalate synthase; Validated; Region: PRK00915
1049565001754	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
1049565001755	active site
1049565001756	catalytic residues [active]
1049565001757	metal binding site [ion binding]; metal-binding site
1049565001758	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
1049565001759	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
1049565001760	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565001761	The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466
1049565001762	putative substrate binding pocket [chemical binding]; other site
1049565001763	putative dimerization interface [polypeptide binding]; other site
1049565001764	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979
1049565001765	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1049565001766	PYR/PP interface [polypeptide binding]; other site
1049565001767	dimer interface [polypeptide binding]; other site
1049565001768	TPP binding site [chemical binding]; other site
1049565001769	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1049565001770	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1049565001771	TPP-binding site [chemical binding]; other site
1049565001772	dimer interface [polypeptide binding]; other site
1049565001773	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
1049565001774	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
1049565001775	putative valine binding site [chemical binding]; other site
1049565001776	dimer interface [polypeptide binding]; other site
1049565001777	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
1049565001778	DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303
1049565001779	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1049565001780	DNA binding site [nucleotide binding]
1049565001781	domain linker motif; other site
1049565001782	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
1049565001783	dimerization interface [polypeptide binding]; other site
1049565001784	ligand binding site [chemical binding]; other site
1049565001785	mraZ protein; Region: TIGR00242
1049565001786	MraZ protein; Region: MraZ; pfam02381
1049565001787	MraZ protein; Region: MraZ; pfam02381
1049565001788	16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006
1049565001789	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
1049565001790	cell division protein FtsL; Provisional; Region: PRK10772
1049565001791	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
1049565001792	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1049565001793	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1049565001794	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
1049565001795	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1049565001796	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1049565001797	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1049565001798	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773
1049565001799	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1049565001800	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1049565001801	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1049565001802	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
1049565001803	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1049565001804	Mg++ binding site [ion binding]; other site
1049565001805	putative catalytic motif [active]
1049565001806	putative substrate binding site [chemical binding]; other site
1049565001807	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806
1049565001808	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1049565001809	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1049565001810	cell division protein FtsW; Provisional; Region: PRK10774
1049565001811	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
1049565001812	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1049565001813	active site
1049565001814	homodimer interface [polypeptide binding]; other site
1049565001815	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1049565001816	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1049565001817	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1049565001818	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1049565001819	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
1049565001820	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1049565001821	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
1049565001822	cell division protein FtsQ; Provisional; Region: PRK10775
1049565001823	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1049565001824	Cell division protein FtsQ; Region: FtsQ; pfam03799
1049565001825	cell division protein FtsA; Reviewed; Region: ftsA; PRK09472
1049565001826	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1049565001827	Cell division protein FtsA; Region: FtsA; pfam14450
1049565001828	cell division protein FtsZ; Validated; Region: PRK09330
1049565001829	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1049565001830	nucleotide binding site [chemical binding]; other site
1049565001831	SulA interaction site; other site
1049565001832	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
1049565001833	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
1049565001834	SecA regulator SecM; Provisional; Region: PRK02943
1049565001835	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
1049565001836	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1049565001837	SEC-C motif; Region: SEC-C; pfam02810
1049565001838	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
1049565001839	active site
1049565001840	8-oxo-dGMP binding site [chemical binding]; other site
1049565001841	nudix motif; other site
1049565001842	metal binding site [ion binding]; metal-binding site
1049565001843	DNA gyrase inhibitor; Reviewed; Region: PRK00418
1049565001844	hypothetical protein; Provisional; Region: PRK05287
1049565001845	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
1049565001846	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1049565001847	CoA-binding site [chemical binding]; other site
1049565001848	ATP-binding [chemical binding]; other site
1049565001849	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096
1049565001850	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1049565001851	active site
1049565001852	type IV pilin biogenesis protein; Provisional; Region: PRK10573
1049565001853	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1049565001854	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1049565001855	hypothetical protein; Provisional; Region: PRK10436
1049565001856	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
1049565001857	Walker A motif; other site
1049565001858	ATP binding site [chemical binding]; other site
1049565001859	Walker B motif; other site
1049565001860	putative major pilin subunit; Provisional; Region: PRK10574
1049565001861	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
1049565001862	Pilin (bacterial filament); Region: Pilin; pfam00114
1049565001863	quinolinate phosphoribosyltransferase; Validated; Region: PRK09016
1049565001864	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
1049565001865	dimerization interface [polypeptide binding]; other site
1049565001866	active site
1049565001867	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
1049565001868	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1049565001869	amidase catalytic site [active]
1049565001870	Zn binding residues [ion binding]; other site
1049565001871	substrate binding site [chemical binding]; other site
1049565001872	regulatory protein AmpE; Provisional; Region: PRK10987
1049565001873	Glycosyl hydrolase family 43; Region: GH43_1; cd08980
1049565001874	active site
1049565001875	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
1049565001876	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565001877	putative substrate translocation pore; other site
1049565001878	aromatic amino acid transporter; Provisional; Region: PRK10238
1049565001879	transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464
1049565001880	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1049565001881	DNA-binding site [nucleotide binding]; DNA binding site
1049565001882	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1049565001883	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
1049565001884	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
1049565001885	dimer interface [polypeptide binding]; other site
1049565001886	TPP-binding site [chemical binding]; other site
1049565001887	pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854
1049565001888	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1049565001889	E3 interaction surface; other site
1049565001890	lipoyl attachment site [posttranslational modification]; other site
1049565001891	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1049565001892	E3 interaction surface; other site
1049565001893	lipoyl attachment site [posttranslational modification]; other site
1049565001894	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1049565001895	E3 interaction surface; other site
1049565001896	lipoyl attachment site [posttranslational modification]; other site
1049565001897	e3 binding domain; Region: E3_binding; pfam02817
1049565001898	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1049565001899	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
1049565001900	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1049565001901	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1049565001902	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1049565001903	Protein of unknown function (DUF2950); Region: DUF2950; pfam11453
1049565001904	Protein of unknown function (DUF3300); Region: DUF3300; pfam11737
1049565001905	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
1049565001906	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
1049565001907	substrate binding site [chemical binding]; other site
1049565001908	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
1049565001909	substrate binding site [chemical binding]; other site
1049565001910	ligand binding site [chemical binding]; other site
1049565001911	hypothetical protein; Provisional; Region: PRK05248
1049565001912	S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462
1049565001913	spermidine synthase; Provisional; Region: PRK00811
1049565001914	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1049565001915	S-adenosylmethionine binding site [chemical binding]; other site
1049565001916	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
1049565001917	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
1049565001918	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1049565001919	Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898
1049565001920	multicopper oxidase; Provisional; Region: PRK10965
1049565001921	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1049565001922	Multicopper oxidase; Region: Cu-oxidase; pfam00394
1049565001923	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
1049565001924	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
1049565001925	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
1049565001926	Trp docking motif [polypeptide binding]; other site
1049565001927	putative active site [active]
1049565001928	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1049565001929	active site
1049565001930	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
1049565001931	active site clefts [active]
1049565001932	zinc binding site [ion binding]; other site
1049565001933	dimer interface [polypeptide binding]; other site
1049565001934	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1049565001935	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1049565001936	Walker A/P-loop; other site
1049565001937	ATP binding site [chemical binding]; other site
1049565001938	Q-loop/lid; other site
1049565001939	ABC transporter signature motif; other site
1049565001940	Walker B; other site
1049565001941	D-loop; other site
1049565001942	H-loop/switch region; other site
1049565001943	inner membrane transport permease; Provisional; Region: PRK15066
1049565001944	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1049565001945	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1049565001946	active pocket/dimerization site; other site
1049565001947	active site
1049565001948	phosphorylation site [posttranslational modification]
1049565001949	Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966
1049565001950	putative active site [active]
1049565001951	putative metal binding site [ion binding]; other site
1049565001952	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
1049565001953	tetramerization interface [polypeptide binding]; other site
1049565001954	active site
1049565001955	pantoate--beta-alanine ligase; Region: panC; TIGR00018
1049565001956	Pantoate-beta-alanine ligase; Region: PanC; cd00560
1049565001957	active site
1049565001958	ATP-binding site [chemical binding]; other site
1049565001959	pantoate-binding site; other site
1049565001960	HXXH motif; other site
1049565001961	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
1049565001962	oligomerization interface [polypeptide binding]; other site
1049565001963	active site
1049565001964	metal binding site [ion binding]; metal-binding site
1049565001965	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1049565001966	catalytic center binding site [active]
1049565001967	ATP binding site [chemical binding]; other site
1049565001968	poly(A) polymerase; Region: pcnB; TIGR01942
1049565001969	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1049565001970	active site
1049565001971	NTP binding site [chemical binding]; other site
1049565001972	metal binding triad [ion binding]; metal-binding site
1049565001973	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1049565001974	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
1049565001975	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
1049565001976	Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008
1049565001977	active site
1049565001978	nucleotide binding site [chemical binding]; other site
1049565001979	HIGH motif; other site
1049565001980	KMSKS motif; other site
1049565001981	RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778
1049565001982	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
1049565001983	2'-5' RNA ligase; Provisional; Region: PRK15124
1049565001984	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
1049565001985	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
1049565001986	ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664
1049565001987	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1049565001988	ATP binding site [chemical binding]; other site
1049565001989	putative Mg++ binding site [ion binding]; other site
1049565001990	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1049565001991	nucleotide binding region [chemical binding]; other site
1049565001992	ATP-binding site [chemical binding]; other site
1049565001993	Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847
1049565001994	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
1049565001995	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
1049565001996	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
1049565001997	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
1049565001998	Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203
1049565001999	Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612
1049565002000	type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709
1049565002001	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
1049565002002	GspL periplasmic domain; Region: GspL_C; pfam12693
1049565002003	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
1049565002004	type II secretion system protein J; Region: gspJ; TIGR01711
1049565002005	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
1049565002006	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
1049565002007	type II secretion system protein I; Region: gspI; TIGR01707
1049565002008	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
1049565002009	type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708
1049565002010	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
1049565002011	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
1049565002012	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
1049565002013	type II secretion system protein F; Region: GspF; TIGR02120
1049565002014	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1049565002015	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1049565002016	type II secretion system protein E; Region: type_II_gspE; TIGR02533
1049565002017	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
1049565002018	Walker A motif; other site
1049565002019	ATP binding site [chemical binding]; other site
1049565002020	Walker B motif; other site
1049565002021	type II secretion system protein D; Region: type_II_gspD; TIGR02517
1049565002022	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1049565002023	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1049565002024	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1049565002025	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1049565002026	type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713
1049565002027	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
1049565002028	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
1049565002029	carbohydrate binding site [chemical binding]; other site
1049565002030	alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103
1049565002031	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
1049565002032	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
1049565002033	Ca binding site [ion binding]; other site
1049565002034	active site
1049565002035	catalytic site [active]
1049565002036	Domain of unknown function (DUF3372); Region: DUF3372; pfam11852
1049565002037	Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898
1049565002038	bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506
1049565002039	Transglycosylase; Region: Transgly; pfam00912
1049565002040	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1049565002041	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
1049565002042	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1049565002043	N-terminal plug; other site
1049565002044	ligand-binding site [chemical binding]; other site
1049565002045	iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575
1049565002046	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1049565002047	Walker A/P-loop; other site
1049565002048	ATP binding site [chemical binding]; other site
1049565002049	Q-loop/lid; other site
1049565002050	ABC transporter signature motif; other site
1049565002051	Walker B; other site
1049565002052	D-loop; other site
1049565002053	H-loop/switch region; other site
1049565002054	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1049565002055	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1049565002056	siderophore binding site; other site
1049565002057	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1049565002058	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1049565002059	ABC-ATPase subunit  interface; other site
1049565002060	dimer interface [polypeptide binding]; other site
1049565002061	putative PBP binding regions; other site
1049565002062	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1049565002063	ABC-ATPase subunit  interface; other site
1049565002064	dimer interface [polypeptide binding]; other site
1049565002065	putative PBP binding regions; other site
1049565002066	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
1049565002067	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1049565002068	inhibitor-cofactor binding pocket; inhibition site
1049565002069	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565002070	catalytic residue [active]
1049565002071	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1049565002072	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
1049565002073	Cl- selectivity filter; other site
1049565002074	Cl- binding residues [ion binding]; other site
1049565002075	pore gating glutamate residue; other site
1049565002076	dimer interface [polypeptide binding]; other site
1049565002077	H+/Cl- coupling transport residue; other site
1049565002078	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
1049565002079	hypothetical protein; Provisional; Region: PRK10578
1049565002080	UPF0126 domain; Region: UPF0126; pfam03458
1049565002081	UPF0126 domain; Region: UPF0126; pfam03458
1049565002082	vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379
1049565002083	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
1049565002084	cobalamin binding residues [chemical binding]; other site
1049565002085	putative BtuC binding residues; other site
1049565002086	dimer interface [polypeptide binding]; other site
1049565002087	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
1049565002088	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
1049565002089	deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926
1049565002090	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1049565002091	Zn2+ binding site [ion binding]; other site
1049565002092	Mg2+ binding site [ion binding]; other site
1049565002093	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
1049565002094	serine endoprotease; Provisional; Region: PRK10942
1049565002095	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1049565002096	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1049565002097	protein binding site [polypeptide binding]; other site
1049565002098	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1049565002099	carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477
1049565002100	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
1049565002101	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1049565002102	hypothetical protein; Provisional; Region: PRK13677
1049565002103	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
1049565002104	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
1049565002105	trimer interface [polypeptide binding]; other site
1049565002106	active site
1049565002107	substrate binding site [chemical binding]; other site
1049565002108	CoA binding site [chemical binding]; other site
1049565002109	PII uridylyl-transferase; Provisional; Region: PRK05007
1049565002110	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1049565002111	metal binding triad; other site
1049565002112	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1049565002113	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1049565002114	Zn2+ binding site [ion binding]; other site
1049565002115	Mg2+ binding site [ion binding]; other site
1049565002116	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
1049565002117	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
1049565002118	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1049565002119	active site
1049565002120	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1049565002121	rRNA interaction site [nucleotide binding]; other site
1049565002122	S8 interaction site; other site
1049565002123	putative laminin-1 binding site; other site
1049565002124	elongation factor Ts; Provisional; Region: tsf; PRK09377
1049565002125	UBA/TS-N domain; Region: UBA; pfam00627
1049565002126	Elongation factor TS; Region: EF_TS; pfam00889
1049565002127	Elongation factor TS; Region: EF_TS; pfam00889
1049565002128	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1049565002129	putative nucleotide binding site [chemical binding]; other site
1049565002130	uridine monophosphate binding site [chemical binding]; other site
1049565002131	homohexameric interface [polypeptide binding]; other site
1049565002132	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1049565002133	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1049565002134	hinge region; other site
1049565002135	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
1049565002136	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
1049565002137	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
1049565002138	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
1049565002139	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
1049565002140	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
1049565002141	catalytic residue [active]
1049565002142	putative FPP diphosphate  binding site; other site
1049565002143	putative FPP binding hydrophobic cleft; other site
1049565002144	dimer interface [polypeptide binding]; other site
1049565002145	putative IPP diphosphate binding site; other site
1049565002146	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
1049565002147	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1049565002148	zinc metallopeptidase RseP; Provisional; Region: PRK10779
1049565002149	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1049565002150	active site
1049565002151	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1049565002152	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1049565002153	protein binding site [polypeptide binding]; other site
1049565002154	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1049565002155	putative substrate binding region [chemical binding]; other site
1049565002156	outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067
1049565002157	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1049565002158	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1049565002159	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1049565002160	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1049565002161	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1049565002162	Surface antigen; Region: Bac_surface_Ag; pfam01103
1049565002163	periplasmic chaperone; Provisional; Region: PRK10780
1049565002164	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
1049565002165	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
1049565002166	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
1049565002167	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
1049565002168	trimer interface [polypeptide binding]; other site
1049565002169	active site
1049565002170	UDP-GlcNAc binding site [chemical binding]; other site
1049565002171	lipid binding site [chemical binding]; lipid-binding site
1049565002172	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1049565002173	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
1049565002174	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
1049565002175	active site
1049565002176	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
1049565002177	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
1049565002178	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1049565002179	RNA/DNA hybrid binding site [nucleotide binding]; other site
1049565002180	active site
1049565002181	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
1049565002182	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
1049565002183	putative active site [active]
1049565002184	putative PHP Thumb interface [polypeptide binding]; other site
1049565002185	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1049565002186	generic binding surface II; other site
1049565002187	generic binding surface I; other site
1049565002188	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
1049565002189	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
1049565002190	lysine decarboxylase LdcC; Provisional; Region: PRK15399
1049565002191	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
1049565002192	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
1049565002193	homodimer interface [polypeptide binding]; other site
1049565002194	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565002195	catalytic residue [active]
1049565002196	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
1049565002197	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
1049565002198	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1049565002199	putative metal binding site [ion binding]; other site
1049565002200	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
1049565002201	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1049565002202	Ligand Binding Site [chemical binding]; other site
1049565002203	TilS substrate binding domain; Region: TilS; pfam09179
1049565002204	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
1049565002205	Rho-binding antiterminator; Provisional; Region: PRK11625
1049565002206	hypothetical protein; Provisional; Region: PRK04964
1049565002207	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681
1049565002208	hypothetical protein; Provisional; Region: PRK09256
1049565002209	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
1049565002210	lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523
1049565002211	NlpE N-terminal domain; Region: NlpE; pfam04170
1049565002212	hypothetical protein; Provisional; Region: PRK11479
1049565002213	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
1049565002214	prolyl-tRNA synthetase; Provisional; Region: PRK09194
1049565002215	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1049565002216	dimer interface [polypeptide binding]; other site
1049565002217	motif 1; other site
1049565002218	active site
1049565002219	motif 2; other site
1049565002220	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
1049565002221	putative deacylase active site [active]
1049565002222	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1049565002223	active site
1049565002224	motif 3; other site
1049565002225	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1049565002226	anticodon binding site; other site
1049565002227	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
1049565002228	homodimer interaction site [polypeptide binding]; other site
1049565002229	cofactor binding site; other site
1049565002230	outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781
1049565002231	DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063
1049565002232	lipoprotein, YaeC family; Region: TIGR00363
1049565002233	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565002234	dimer interface [polypeptide binding]; other site
1049565002235	conserved gate region; other site
1049565002236	ABC-ATPase subunit interface; other site
1049565002237	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
1049565002238	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1049565002239	Walker A/P-loop; other site
1049565002240	ATP binding site [chemical binding]; other site
1049565002241	Q-loop/lid; other site
1049565002242	ABC transporter signature motif; other site
1049565002243	Walker B; other site
1049565002244	D-loop; other site
1049565002245	H-loop/switch region; other site
1049565002246	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
1049565002247	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
1049565002248	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1049565002249	active site
1049565002250	motif I; other site
1049565002251	motif II; other site
1049565002252	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1049565002253	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1049565002254	active site
1049565002255	catalytic tetrad [active]
1049565002256	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565002257	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565002258	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478
1049565002259	putative effector binding pocket; other site
1049565002260	dimerization interface [polypeptide binding]; other site
1049565002261	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1049565002262	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565002263	putative substrate translocation pore; other site
1049565002264	hypothetical protein; Provisional; Region: PRK05421
1049565002265	putative catalytic site [active]
1049565002266	putative metal binding site [ion binding]; other site
1049565002267	putative phosphate binding site [ion binding]; other site
1049565002268	putative catalytic site [active]
1049565002269	putative phosphate binding site [ion binding]; other site
1049565002270	putative metal binding site [ion binding]; other site
1049565002271	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1049565002272	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1049565002273	S-adenosylmethionine binding site [chemical binding]; other site
1049565002274	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
1049565002275	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1049565002276	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1049565002277	catalytic residue [active]
1049565002278	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1049565002279	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1049565002280	hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241
1049565002281	Methyltransferase domain; Region: Methyltransf_11; pfam08241
1049565002282	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
1049565002283	RNA/DNA hybrid binding site [nucleotide binding]; other site
1049565002284	active site
1049565002285	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
1049565002286	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
1049565002287	active site
1049565002288	catalytic site [active]
1049565002289	substrate binding site [chemical binding]; other site
1049565002290	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565002291	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565002292	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1049565002293	dimerization interface [polypeptide binding]; other site
1049565002294	cysteine/O-acetylserine exporter; Provisional; Region: PRK10323
1049565002295	C-N hydrolase family amidase; Provisional; Region: PRK10438
1049565002296	Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575
1049565002297	putative active site [active]
1049565002298	catalytic triad [active]
1049565002299	dimer interface [polypeptide binding]; other site
1049565002300	multimer interface [polypeptide binding]; other site
1049565002301	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
1049565002302	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1049565002303	active site
1049565002304	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
1049565002305	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
1049565002306	dimer interface [polypeptide binding]; other site
1049565002307	active site
1049565002308	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
1049565002309	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
1049565002310	putative active site [active]
1049565002311	putative dimer interface [polypeptide binding]; other site
1049565002312	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
1049565002313	Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352
1049565002314	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1049565002315	E3 interaction surface; other site
1049565002316	lipoyl attachment site [posttranslational modification]; other site
1049565002317	NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973
1049565002318	Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349
1049565002319	Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346
1049565002320	NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938
1049565002321	Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292
1049565002322	Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830
1049565002323	Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464
1049565002324	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1049565002325	catalytic loop [active]
1049565002326	iron binding site [ion binding]; other site
1049565002327	Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188
1049565002328	FAD binding pocket [chemical binding]; other site
1049565002329	FAD binding motif [chemical binding]; other site
1049565002330	phosphate binding motif [ion binding]; other site
1049565002331	beta-alpha-beta structure motif; other site
1049565002332	NAD binding pocket [chemical binding]; other site
1049565002333	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2991
1049565002334	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1049565002335	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
1049565002336	active site
1049565002337	catalytic site [active]
1049565002338	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1049565002339	active site
1049565002340	DNA polymerase IV; Validated; Region: PRK02406
1049565002341	DNA binding site [nucleotide binding]
1049565002342	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1049565002343	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1049565002344	Coenzyme A binding pocket [chemical binding]; other site
1049565002345	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
1049565002346	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
1049565002347	metal binding site [ion binding]; metal-binding site
1049565002348	dimer interface [polypeptide binding]; other site
1049565002349	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1049565002350	active site
1049565002351	fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077
1049565002352	DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984
1049565002353	DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534
1049565002354	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1049565002355	DNA-binding site [nucleotide binding]; DNA binding site
1049565002356	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1049565002357	gamma-aminobutyrate transporter; Provisional; Region: PRK10197
1049565002358	4-aminobutyrate aminotransferase; Validated; Region: PRK08088
1049565002359	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1049565002360	inhibitor-cofactor binding pocket; inhibition site
1049565002361	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565002362	catalytic residue [active]
1049565002363	succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241
1049565002364	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1049565002365	tetramerization interface [polypeptide binding]; other site
1049565002366	NAD(P) binding site [chemical binding]; other site
1049565002367	catalytic residues [active]
1049565002368	Predicted dehydrogenase [General function prediction only]; Region: COG0579
1049565002369	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1049565002370	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250
1049565002371	substrate binding pocket [chemical binding]; other site
1049565002372	active site
1049565002373	iron coordination sites [ion binding]; other site
1049565002374	hypothetical protein; Provisional; Region: PRK13687
1049565002375	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1049565002376	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1049565002377	S-adenosylmethionine binding site [chemical binding]; other site
1049565002378	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1049565002379	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
1049565002380	putative C-terminal domain interface [polypeptide binding]; other site
1049565002381	putative GSH binding site (G-site) [chemical binding]; other site
1049565002382	putative dimer interface [polypeptide binding]; other site
1049565002383	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
1049565002384	putative N-terminal domain interface [polypeptide binding]; other site
1049565002385	putative dimer interface [polypeptide binding]; other site
1049565002386	putative substrate binding pocket (H-site) [chemical binding]; other site
1049565002387	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
1049565002388	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1049565002389	active site
1049565002390	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
1049565002391	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
1049565002392	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1049565002393	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1049565002394	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1049565002395	E3 interaction surface; other site
1049565002396	lipoyl attachment site [posttranslational modification]; other site
1049565002397	e3 binding domain; Region: E3_binding; pfam02817
1049565002398	dihydrolipoamide acetyltransferase; Provisional; Region: PRK14843
1049565002399	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1049565002400	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1049565002401	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1049565002402	alpha subunit interface [polypeptide binding]; other site
1049565002403	TPP binding site [chemical binding]; other site
1049565002404	heterodimer interface [polypeptide binding]; other site
1049565002405	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1049565002406	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
1049565002407	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1049565002408	tetramer interface [polypeptide binding]; other site
1049565002409	TPP-binding site [chemical binding]; other site
1049565002410	heterodimer interface [polypeptide binding]; other site
1049565002411	phosphorylation loop region [posttranslational modification]
1049565002412	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
1049565002413	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1049565002414	DNA binding residues [nucleotide binding]
1049565002415	dimerization interface [polypeptide binding]; other site
1049565002416	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
1049565002417	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1049565002418	carboxyltransferase (CT) interaction site; other site
1049565002419	biotinylation site [posttranslational modification]; other site
1049565002420	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1049565002421	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1049565002422	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1049565002423	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1049565002424	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
1049565002425	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1049565002426	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
1049565002427	NAD(P) binding site [chemical binding]; other site
1049565002428	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1049565002429	EamA-like transporter family; Region: EamA; pfam00892
1049565002430	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1049565002431	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1049565002432	substrate binding pocket [chemical binding]; other site
1049565002433	membrane-bound complex binding site; other site
1049565002434	hinge residues; other site
1049565002435	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
1049565002436	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
1049565002437	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
1049565002438	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
1049565002439	putative active site [active]
1049565002440	aspartate aminotransferase; Provisional; Region: PRK05764
1049565002441	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1049565002442	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565002443	homodimer interface [polypeptide binding]; other site
1049565002444	catalytic residue [active]
1049565002445	nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233
1049565002446	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565002447	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
1049565002448	putative dimerization interface [polypeptide binding]; other site
1049565002449	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
1049565002450	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1049565002451	carboxyltransferase (CT) interaction site; other site
1049565002452	biotinylation site [posttranslational modification]; other site
1049565002453	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1049565002454	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1049565002455	NAD(P) binding site [chemical binding]; other site
1049565002456	active site
1049565002457	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565002458	dimer interface [polypeptide binding]; other site
1049565002459	conserved gate region; other site
1049565002460	putative PBP binding loops; other site
1049565002461	ABC-ATPase subunit interface; other site
1049565002462	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565002463	dimer interface [polypeptide binding]; other site
1049565002464	conserved gate region; other site
1049565002465	putative PBP binding loops; other site
1049565002466	ABC-ATPase subunit interface; other site
1049565002467	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1049565002468	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1049565002469	Walker A/P-loop; other site
1049565002470	ATP binding site [chemical binding]; other site
1049565002471	Q-loop/lid; other site
1049565002472	ABC transporter signature motif; other site
1049565002473	Walker B; other site
1049565002474	D-loop; other site
1049565002475	H-loop/switch region; other site
1049565002476	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
1049565002477	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
1049565002478	putative catalytic cysteine [active]
1049565002479	gamma-glutamyl kinase; Provisional; Region: PRK05429
1049565002480	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
1049565002481	nucleotide binding site [chemical binding]; other site
1049565002482	homotetrameric interface [polypeptide binding]; other site
1049565002483	putative phosphate binding site [ion binding]; other site
1049565002484	putative allosteric binding site; other site
1049565002485	PUA domain; Region: PUA; pfam01472
1049565002486	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1049565002487	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1049565002488	trimer interface [polypeptide binding]; other site
1049565002489	eyelet of channel; other site
1049565002490	NlpC/P60 family; Region: NLPC_P60; pfam00877
1049565002491	EamA-like transporter family; Region: EamA; pfam00892
1049565002492	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
1049565002493	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1049565002494	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1049565002495	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1049565002496	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1049565002497	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565002498	dimer interface [polypeptide binding]; other site
1049565002499	conserved gate region; other site
1049565002500	putative PBP binding loops; other site
1049565002501	ABC-ATPase subunit interface; other site
1049565002502	phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431
1049565002503	Transferrin; Region: Transferrin; cl02460
1049565002504	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
1049565002505	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
1049565002506	Walker A/P-loop; other site
1049565002507	ATP binding site [chemical binding]; other site
1049565002508	Q-loop/lid; other site
1049565002509	ABC transporter signature motif; other site
1049565002510	Walker B; other site
1049565002511	D-loop; other site
1049565002512	H-loop/switch region; other site
1049565002513	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1049565002514	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1049565002515	DNA binding residues [nucleotide binding]
1049565002516	putative fimbrial protein TcfA; Provisional; Region: PRK15308
1049565002517	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
1049565002518	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
1049565002519	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
1049565002520	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565002521	dimer interface [polypeptide binding]; other site
1049565002522	conserved gate region; other site
1049565002523	putative PBP binding loops; other site
1049565002524	ABC-ATPase subunit interface; other site
1049565002525	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565002526	dimer interface [polypeptide binding]; other site
1049565002527	conserved gate region; other site
1049565002528	putative PBP binding loops; other site
1049565002529	ABC-ATPase subunit interface; other site
1049565002530	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1049565002531	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1049565002532	Walker A/P-loop; other site
1049565002533	ATP binding site [chemical binding]; other site
1049565002534	Q-loop/lid; other site
1049565002535	ABC transporter signature motif; other site
1049565002536	Walker B; other site
1049565002537	D-loop; other site
1049565002538	H-loop/switch region; other site
1049565002539	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1049565002540	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1049565002541	substrate binding pocket [chemical binding]; other site
1049565002542	membrane-bound complex binding site; other site
1049565002543	hinge residues; other site
1049565002544	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1049565002545	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1049565002546	Walker A/P-loop; other site
1049565002547	ATP binding site [chemical binding]; other site
1049565002548	Q-loop/lid; other site
1049565002549	ABC transporter signature motif; other site
1049565002550	Walker B; other site
1049565002551	D-loop; other site
1049565002552	H-loop/switch region; other site
1049565002553	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1049565002554	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1049565002555	Walker A/P-loop; other site
1049565002556	ATP binding site [chemical binding]; other site
1049565002557	Q-loop/lid; other site
1049565002558	ABC transporter signature motif; other site
1049565002559	Walker B; other site
1049565002560	D-loop; other site
1049565002561	H-loop/switch region; other site
1049565002562	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1049565002563	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1049565002564	TM-ABC transporter signature motif; other site
1049565002565	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1049565002566	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1049565002567	TM-ABC transporter signature motif; other site
1049565002568	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1049565002569	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
1049565002570	putative ligand binding site [chemical binding]; other site
1049565002571	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
1049565002572	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
1049565002573	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
1049565002574	ethanolamine permease; Region: 2A0305; TIGR00908
1049565002575	S-methylmethionine transporter; Provisional; Region: PRK11387
1049565002576	homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485
1049565002577	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
1049565002578	taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729
1049565002579	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1049565002580	substrate binding pocket [chemical binding]; other site
1049565002581	membrane-bound complex binding site; other site
1049565002582	hinge residues; other site
1049565002583	taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248
1049565002584	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1049565002585	Walker A/P-loop; other site
1049565002586	ATP binding site [chemical binding]; other site
1049565002587	Q-loop/lid; other site
1049565002588	ABC transporter signature motif; other site
1049565002589	Walker B; other site
1049565002590	D-loop; other site
1049565002591	H-loop/switch region; other site
1049565002592	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1049565002593	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565002594	dimer interface [polypeptide binding]; other site
1049565002595	conserved gate region; other site
1049565002596	putative PBP binding loops; other site
1049565002597	ABC-ATPase subunit interface; other site
1049565002598	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
1049565002599	taurine dioxygenase; Reviewed; Region: tauD; PRK09553
1049565002600	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
1049565002601	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1049565002602	putative acyl-acceptor binding pocket; other site
1049565002603	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
1049565002604	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565002605	putative substrate translocation pore; other site
1049565002606	Sigma-S stabilisation anti-adaptor protein; Region: Anti-adapt_IraP; pfam10796
1049565002607	alkaline phosphatase; Provisional; Region: PRK10518
1049565002608	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
1049565002609	active site
1049565002610	dimer interface [polypeptide binding]; other site
1049565002611	hypothetical protein; Provisional; Region: PRK11505
1049565002612	psiF repeat; Region: PsiF_repeat; pfam07769
1049565002613	psiF repeat; Region: PsiF_repeat; pfam07769
1049565002614	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
1049565002615	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1049565002616	hypothetical protein; Validated; Region: PRK00124
1049565002617	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849
1049565002618	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
1049565002619	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1049565002620	ADP binding site [chemical binding]; other site
1049565002621	magnesium binding site [ion binding]; other site
1049565002622	putative shikimate binding site; other site
1049565002623	hypothetical protein; Provisional; Region: PRK10380
1049565002624	hypothetical protein; Provisional; Region: PRK10481
1049565002625	hypothetical protein; Provisional; Region: PRK10579
1049565002626	recombination associated protein; Reviewed; Region: rdgC; PRK00321
1049565002627	fructokinase; Reviewed; Region: PRK09557
1049565002628	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1049565002629	nucleotide binding site [chemical binding]; other site
1049565002630	Acetokinase family; Region: Acetate_kinase; cl17229
1049565002631	exonuclease subunit SbcC; Provisional; Region: PRK10246
1049565002632	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1049565002633	Walker A/P-loop; other site
1049565002634	ATP binding site [chemical binding]; other site
1049565002635	Q-loop/lid; other site
1049565002636	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1049565002637	ABC transporter signature motif; other site
1049565002638	Walker B; other site
1049565002639	D-loop; other site
1049565002640	H-loop/switch region; other site
1049565002641	exonuclease subunit SbcD; Provisional; Region: PRK10966
1049565002642	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1049565002643	active site
1049565002644	metal binding site [ion binding]; metal-binding site
1049565002645	DNA binding site [nucleotide binding]
1049565002646	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
1049565002647	transcriptional regulator PhoB; Provisional; Region: PRK10161
1049565002648	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1049565002649	active site
1049565002650	phosphorylation site [posttranslational modification]
1049565002651	intermolecular recognition site; other site
1049565002652	dimerization interface [polypeptide binding]; other site
1049565002653	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1049565002654	DNA binding site [nucleotide binding]
1049565002655	phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006
1049565002656	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
1049565002657	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1049565002658	putative active site [active]
1049565002659	heme pocket [chemical binding]; other site
1049565002660	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1049565002661	dimer interface [polypeptide binding]; other site
1049565002662	phosphorylation site [posttranslational modification]
1049565002663	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1049565002664	ATP binding site [chemical binding]; other site
1049565002665	Mg2+ binding site [ion binding]; other site
1049565002666	G-X-G motif; other site
1049565002667	branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433
1049565002668	putative proline-specific permease; Provisional; Region: proY; PRK10580
1049565002669	maltodextrin glucosidase; Provisional; Region: PRK10785
1049565002670	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
1049565002671	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
1049565002672	active site
1049565002673	homodimer interface [polypeptide binding]; other site
1049565002674	catalytic site [active]
1049565002675	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565002676	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
1049565002677	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1049565002678	dimerization interface [polypeptide binding]; other site
1049565002679	Isochorismatase family; Region: Isochorismatase; pfam00857
1049565002680	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
1049565002681	catalytic triad [active]
1049565002682	dimer interface [polypeptide binding]; other site
1049565002683	conserved cis-peptide bond; other site
1049565002684	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
1049565002685	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
1049565002686	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
1049565002687	active site
1049565002688	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1049565002689	intersubunit interface [polypeptide binding]; other site
1049565002690	active site
1049565002691	zinc binding site [ion binding]; other site
1049565002692	Na+ binding site [ion binding]; other site
1049565002693	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1049565002694	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1049565002695	substrate binding site [chemical binding]; other site
1049565002696	ATP binding site [chemical binding]; other site
1049565002697	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
1049565002698	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
1049565002699	active site
1049565002700	P-loop; other site
1049565002701	phosphorylation site [posttranslational modification]
1049565002702	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1049565002703	active site
1049565002704	phosphorylation site [posttranslational modification]
1049565002705	peroxidase; Provisional; Region: PRK15000
1049565002706	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1049565002707	dimer interface [polypeptide binding]; other site
1049565002708	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1049565002709	catalytic triad [active]
1049565002710	peroxidatic and resolving cysteines [active]
1049565002711	acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045
1049565002712	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
1049565002713	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
1049565002714	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
1049565002715	tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449
1049565002716	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
1049565002717	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
1049565002718	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
1049565002719	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
1049565002720	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
1049565002721	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
1049565002722	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
1049565002723	Protein export membrane protein; Region: SecD_SecF; pfam02355
1049565002724	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1049565002725	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1049565002726	Predicted transcriptional regulator [Transcription]; Region: COG2378
1049565002727	HTH domain; Region: HTH_11; pfam08279
1049565002728	WYL domain; Region: WYL; pfam13280
1049565002729	nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106
1049565002730	hypothetical protein; Provisional; Region: PRK11530
1049565002731	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
1049565002732	ATP cone domain; Region: ATP-cone; pfam03477
1049565002733	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
1049565002734	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
1049565002735	catalytic motif [active]
1049565002736	Zn binding site [ion binding]; other site
1049565002737	RibD C-terminal domain; Region: RibD_C; cl17279
1049565002738	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
1049565002739	homopentamer interface [polypeptide binding]; other site
1049565002740	active site
1049565002741	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
1049565002742	putative RNA binding site [nucleotide binding]; other site
1049565002743	thiamine monophosphate kinase; Provisional; Region: PRK05731
1049565002744	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
1049565002745	ATP binding site [chemical binding]; other site
1049565002746	dimerization interface [polypeptide binding]; other site
1049565002747	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
1049565002748	tetramer interfaces [polypeptide binding]; other site
1049565002749	binuclear metal-binding site [ion binding]; other site
1049565002750	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1049565002751	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1049565002752	active site
1049565002753	catalytic tetrad [active]
1049565002754	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
1049565002755	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
1049565002756	TPP-binding site; other site
1049565002757	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1049565002758	PYR/PP interface [polypeptide binding]; other site
1049565002759	dimer interface [polypeptide binding]; other site
1049565002760	TPP binding site [chemical binding]; other site
1049565002761	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1049565002762	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1049565002763	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1049565002764	substrate binding pocket [chemical binding]; other site
1049565002765	chain length determination region; other site
1049565002766	substrate-Mg2+ binding site; other site
1049565002767	catalytic residues [active]
1049565002768	aspartate-rich region 1; other site
1049565002769	active site lid residues [active]
1049565002770	aspartate-rich region 2; other site
1049565002771	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
1049565002772	tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269
1049565002773	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
1049565002774	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
1049565002775	Ligand Binding Site [chemical binding]; other site
1049565002776	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1049565002777	active site residue [active]
1049565002778	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896
1049565002779	putative hydrophobic ligand binding site [chemical binding]; other site
1049565002780	oxidative-stress-resistance chaperone; Provisional; Region: PRK11574
1049565002781	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
1049565002782	conserved cys residue [active]
1049565002783	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
1049565002784	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1049565002785	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1049565002786	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
1049565002787	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
1049565002788	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565002789	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1049565002790	putative substrate translocation pore; other site
1049565002791	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1049565002792	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1049565002793	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1049565002794	benzoate transport; Region: 2A0115; TIGR00895
1049565002795	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565002796	putative substrate translocation pore; other site
1049565002797	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565002798	putative substrate translocation pore; other site
1049565002799	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1049565002800	putative FAD-binding dehydrogenase; Reviewed; Region: PRK06134
1049565002801	Predicted oxidoreductase [General function prediction only]; Region: COG3573
1049565002802	NIPSNAP; Region: NIPSNAP; pfam07978
1049565002803	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12843
1049565002804	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
1049565002805	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
1049565002806	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1049565002807	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1049565002808	shikimate binding site; other site
1049565002809	NAD(P) binding site [chemical binding]; other site
1049565002810	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
1049565002811	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1049565002812	Bacterial transcriptional regulator; Region: IclR; pfam01614
1049565002813	protoheme IX farnesyltransferase; Provisional; Region: PRK13362
1049565002814	UbiA prenyltransferase family; Region: UbiA; pfam01040
1049565002815	cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582
1049565002816	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
1049565002817	Subunit I/III interface [polypeptide binding]; other site
1049565002818	Subunit III/IV interface [polypeptide binding]; other site
1049565002819	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1049565002820	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
1049565002821	D-pathway; other site
1049565002822	Putative ubiquinol binding site [chemical binding]; other site
1049565002823	Low-spin heme (heme b) binding site [chemical binding]; other site
1049565002824	Putative water exit pathway; other site
1049565002825	Binuclear center (heme o3/CuB) [ion binding]; other site
1049565002826	K-pathway; other site
1049565002827	Putative proton exit pathway; other site
1049565002828	cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525
1049565002829	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1049565002830	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
1049565002831	muropeptide transporter; Reviewed; Region: ampG; PRK11902
1049565002832	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565002833	putative substrate translocation pore; other site
1049565002834	hypothetical protein; Provisional; Region: PRK11627
1049565002835	Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923
1049565002836	transcriptional regulator BolA; Provisional; Region: PRK11628
1049565002837	trigger factor; Provisional; Region: tig; PRK01490
1049565002838	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1049565002839	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1049565002840	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
1049565002841	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1049565002842	oligomer interface [polypeptide binding]; other site
1049565002843	active site residues [active]
1049565002844	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1049565002845	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
1049565002846	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1049565002847	Walker A motif; other site
1049565002848	ATP binding site [chemical binding]; other site
1049565002849	Walker B motif; other site
1049565002850	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1049565002851	DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787
1049565002852	Found in ATP-dependent protease La (LON); Region: LON; smart00464
1049565002853	Found in ATP-dependent protease La (LON); Region: LON; smart00464
1049565002854	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1049565002855	Walker A motif; other site
1049565002856	ATP binding site [chemical binding]; other site
1049565002857	Walker B motif; other site
1049565002858	arginine finger; other site
1049565002859	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1049565002860	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1049565002861	IHF dimer interface [polypeptide binding]; other site
1049565002862	IHF - DNA interface [nucleotide binding]; other site
1049565002863	periplasmic folding chaperone; Provisional; Region: PRK10788
1049565002864	SurA N-terminal domain; Region: SurA_N_3; cl07813
1049565002865	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
1049565002866	competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426
1049565002867	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1049565002868	active site
1049565002869	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
1049565002870	Ligand Binding Site [chemical binding]; other site
1049565002871	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
1049565002872	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
1049565002873	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1049565002874	thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126
1049565002875	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1049565002876	active site
1049565002877	motif I; other site
1049565002878	motif II; other site
1049565002879	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1049565002880	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1049565002881	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
1049565002882	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1049565002883	catalytic residue [active]
1049565002884	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1049565002885	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1049565002886	putative DNA binding site [nucleotide binding]; other site
1049565002887	putative Zn2+ binding site [ion binding]; other site
1049565002888	AsnC family; Region: AsnC_trans_reg; pfam01037
1049565002889	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
1049565002890	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1049565002891	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1049565002892	Walker A/P-loop; other site
1049565002893	ATP binding site [chemical binding]; other site
1049565002894	Q-loop/lid; other site
1049565002895	ABC transporter signature motif; other site
1049565002896	Walker B; other site
1049565002897	D-loop; other site
1049565002898	H-loop/switch region; other site
1049565002899	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790
1049565002900	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1049565002901	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1049565002902	Walker A/P-loop; other site
1049565002903	ATP binding site [chemical binding]; other site
1049565002904	Q-loop/lid; other site
1049565002905	ABC transporter signature motif; other site
1049565002906	Walker B; other site
1049565002907	D-loop; other site
1049565002908	H-loop/switch region; other site
1049565002909	nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665
1049565002910	Nitrogen regulatory protein P-II; Region: P-II; smart00938
1049565002911	ammonium transporter; Provisional; Region: PRK10666
1049565002912	acyl-CoA thioesterase II; Provisional; Region: PRK10526
1049565002913	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
1049565002914	active site
1049565002915	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
1049565002916	catalytic triad [active]
1049565002917	dimer interface [polypeptide binding]; other site
1049565002918	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126
1049565002919	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1049565002920	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1049565002921	DNA binding site [nucleotide binding]
1049565002922	active site
1049565002923	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1049565002924	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1049565002925	DNA-binding site [nucleotide binding]; DNA binding site
1049565002926	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1049565002927	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565002928	homodimer interface [polypeptide binding]; other site
1049565002929	catalytic residue [active]
1049565002930	Predicted membrane protein [Function unknown]; Region: COG2364
1049565002931	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1049565002932	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1049565002933	nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019
1049565002934	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
1049565002935	putative metal binding site [ion binding]; other site
1049565002936	putative homodimer interface [polypeptide binding]; other site
1049565002937	putative homotetramer interface [polypeptide binding]; other site
1049565002938	putative homodimer-homodimer interface [polypeptide binding]; other site
1049565002939	putative allosteric switch controlling residues; other site
1049565002940	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
1049565002941	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
1049565002942	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1049565002943	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1049565002944	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1049565002945	Walker A/P-loop; other site
1049565002946	ATP binding site [chemical binding]; other site
1049565002947	Q-loop/lid; other site
1049565002948	ABC transporter signature motif; other site
1049565002949	Walker B; other site
1049565002950	D-loop; other site
1049565002951	H-loop/switch region; other site
1049565002952	TOBE domain; Region: TOBE_2; pfam08402
1049565002953	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
1049565002954	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1049565002955	DAK2 domain; Region: Dak2; cl03685
1049565002956	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565002957	dimer interface [polypeptide binding]; other site
1049565002958	conserved gate region; other site
1049565002959	ABC-ATPase subunit interface; other site
1049565002960	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1049565002961	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565002962	dimer interface [polypeptide binding]; other site
1049565002963	conserved gate region; other site
1049565002964	putative PBP binding loops; other site
1049565002965	ABC-ATPase subunit interface; other site
1049565002966	Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672
1049565002967	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
1049565002968	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
1049565002969	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
1049565002970	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
1049565002971	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1049565002972	active site turn [active]
1049565002973	phosphorylation site [posttranslational modification]
1049565002974	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
1049565002975	trimer interface; other site
1049565002976	sugar binding site [chemical binding]; other site
1049565002977	lac repressor; Reviewed; Region: lacI; PRK09526
1049565002978	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1049565002979	DNA binding site [nucleotide binding]
1049565002980	domain linker motif; other site
1049565002981	Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574
1049565002982	ligand binding site [chemical binding]; other site
1049565002983	dimerization interface (open form) [polypeptide binding]; other site
1049565002984	dimerization interface (closed form) [polypeptide binding]; other site
1049565002985	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
1049565002986	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
1049565002987	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1049565002988	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1049565002989	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1049565002990	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1049565002991	DNA-binding site [nucleotide binding]; DNA binding site
1049565002992	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1049565002993	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565002994	homodimer interface [polypeptide binding]; other site
1049565002995	catalytic residue [active]
1049565002996	sigma70 family sigma factor YlaC; Region: YlaC; pfam10777
1049565002997	maltose O-acetyltransferase; Provisional; Region: PRK10092
1049565002998	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
1049565002999	active site
1049565003000	substrate binding site [chemical binding]; other site
1049565003001	trimer interface [polypeptide binding]; other site
1049565003002	CoA binding site [chemical binding]; other site
1049565003003	gene expression modulator; Provisional; Region: PRK10945
1049565003004	Hha toxicity attenuator; Provisional; Region: PRK10667
1049565003005	multidrug efflux system protein AcrB; Provisional; Region: PRK15127
1049565003006	Protein export membrane protein; Region: SecD_SecF; cl14618
1049565003007	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
1049565003008	HlyD family secretion protein; Region: HlyD_3; pfam13437
1049565003009	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
1049565003010	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1049565003011	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
1049565003012	hypothetical protein; Provisional; Region: PRK11281
1049565003013	M domain of GW182; Region: M_domain; pfam12938
1049565003014	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
1049565003015	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
1049565003016	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1049565003017	putative transposase; Provisional; Region: PRK09857
1049565003018	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
1049565003019	hypothetical protein; Provisional; Region: PRK11038
1049565003020	primosomal replication protein N''; Provisional; Region: PRK10093
1049565003021	hypothetical protein; Provisional; Region: PRK10527
1049565003022	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1049565003023	active site
1049565003024	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994
1049565003025	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1049565003026	Walker A motif; other site
1049565003027	ATP binding site [chemical binding]; other site
1049565003028	Walker B motif; other site
1049565003029	arginine finger; other site
1049565003030	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
1049565003031	DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168
1049565003032	DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170
1049565003033	hypothetical protein; Validated; Region: PRK00153
1049565003034	recombination protein RecR; Reviewed; Region: recR; PRK00076
1049565003035	RecR protein; Region: RecR; pfam02132
1049565003036	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1049565003037	putative active site [active]
1049565003038	putative metal-binding site [ion binding]; other site
1049565003039	tetramer interface [polypeptide binding]; other site
1049565003040	heat shock protein 90; Provisional; Region: PRK05218
1049565003041	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1049565003042	ATP binding site [chemical binding]; other site
1049565003043	Mg2+ binding site [ion binding]; other site
1049565003044	G-X-G motif; other site
1049565003045	adenylate kinase; Reviewed; Region: adk; PRK00279
1049565003046	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1049565003047	AMP-binding site [chemical binding]; other site
1049565003048	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1049565003049	ferrochelatase; Reviewed; Region: hemH; PRK00035
1049565003050	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
1049565003051	C-terminal domain interface [polypeptide binding]; other site
1049565003052	active site
1049565003053	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
1049565003054	active site
1049565003055	N-terminal domain interface [polypeptide binding]; other site
1049565003056	inosine/guanosine kinase; Provisional; Region: PRK15074
1049565003057	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1049565003058	putative cation:proton antiport protein; Provisional; Region: PRK10669
1049565003059	Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651
1049565003060	TrkA-N domain; Region: TrkA_N; pfam02254
1049565003061	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565003062	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1049565003063	putative substrate translocation pore; other site
1049565003064	bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558
1049565003065	Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405
1049565003066	active site
1049565003067	metal binding site [ion binding]; metal-binding site
1049565003068	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1049565003069	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
1049565003070	putative deacylase active site [active]
1049565003071	TraB family; Region: TraB; cl12050
1049565003072	copper exporting ATPase; Provisional; Region: copA; PRK10671
1049565003073	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1049565003074	metal-binding site [ion binding]
1049565003075	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1049565003076	metal-binding site [ion binding]
1049565003077	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1049565003078	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1049565003079	motif II; other site
1049565003080	DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227
1049565003081	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
1049565003082	DNA binding residues [nucleotide binding]
1049565003083	dimer interface [polypeptide binding]; other site
1049565003084	copper binding site [ion binding]; other site
1049565003085	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
1049565003086	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1049565003087	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
1049565003088	putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247
1049565003089	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1049565003090	Walker A/P-loop; other site
1049565003091	ATP binding site [chemical binding]; other site
1049565003092	Q-loop/lid; other site
1049565003093	ABC transporter signature motif; other site
1049565003094	Walker B; other site
1049565003095	D-loop; other site
1049565003096	H-loop/switch region; other site
1049565003097	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
1049565003098	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
1049565003099	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
1049565003100	oxidoreductase; Provisional; Region: PRK08017
1049565003101	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
1049565003102	NADP binding site [chemical binding]; other site
1049565003103	active site
1049565003104	steroid binding site; other site
1049565003105	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
1049565003106	active site
1049565003107	catalytic triad [active]
1049565003108	oxyanion hole [active]
1049565003109	switch loop; other site
1049565003110	putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584
1049565003111	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1049565003112	Walker A/P-loop; other site
1049565003113	ATP binding site [chemical binding]; other site
1049565003114	Q-loop/lid; other site
1049565003115	ABC transporter signature motif; other site
1049565003116	Walker B; other site
1049565003117	D-loop; other site
1049565003118	H-loop/switch region; other site
1049565003119	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
1049565003120	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
1049565003121	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1049565003122	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1049565003123	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
1049565003124	Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520
1049565003125	active site residue [active]
1049565003126	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
1049565003127	ATP-grasp domain; Region: ATP-grasp; pfam02222
1049565003128	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
1049565003129	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
1049565003130	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1049565003131	putative active site [active]
1049565003132	putative metal binding site [ion binding]; other site
1049565003133	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
1049565003134	substrate binding site [chemical binding]; other site
1049565003135	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1049565003136	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1049565003137	active site
1049565003138	HIGH motif; other site
1049565003139	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1049565003140	KMSKS motif; other site
1049565003141	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
1049565003142	tRNA binding surface [nucleotide binding]; other site
1049565003143	anticodon binding site; other site
1049565003144	ribosome-associated protein; Provisional; Region: PRK11507
1049565003145	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
1049565003146	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1049565003147	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1049565003148	homodimer interface [polypeptide binding]; other site
1049565003149	NADP binding site [chemical binding]; other site
1049565003150	substrate binding site [chemical binding]; other site
1049565003151	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
1049565003152	P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192
1049565003153	Int/Topo IB signature motif; other site
1049565003154	DksA-like zinc finger domain containing protein; Region: PHA00080
1049565003155	MT-A70; Region: MT-A70; cl01947
1049565003156	YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588
1049565003157	RecT family; Region: RecT; cl04285
1049565003158	HNH endonuclease; Region: HNH_3; pfam13392
1049565003159	AP2 domain; Region: AP2; pfam00847
1049565003160	FtsZ inhibitor protein; Reviewed; Region: kil; PRK11354
1049565003161	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
1049565003162	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907
1049565003163	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1049565003164	Predicted transcriptional regulator [Transcription]; Region: COG2932
1049565003165	sequence-specific DNA binding site [nucleotide binding]; other site
1049565003166	salt bridge; other site
1049565003167	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1049565003168	Catalytic site [active]
1049565003169	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1049565003170	sequence-specific DNA binding site [nucleotide binding]; other site
1049565003171	salt bridge; other site
1049565003172	Bacteriophage CII protein; Region: Phage_CII; pfam05269
1049565003173	Helix-turn-helix domain; Region: HTH_36; pfam13730
1049565003174	Replication protein P; Region: Phage_lambda_P; pfam06992
1049565003175	MarR family; Region: MarR_2; pfam12802
1049565003176	Flagellar protein (FlbD); Region: FlbD; cl00683
1049565003177	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1049565003178	active site
1049565003179	Protein of unknown function (DUF551); Region: DUF551; pfam04448
1049565003180	Protein of unknown function (DUF1367); Region: DUF1367; pfam07105
1049565003181	prophage protein NinE; Provisional; Region: PRK09689
1049565003182	Bacteriophage Lambda NinG protein; Region: NinG; pfam05766
1049565003183	Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323
1049565003184	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
1049565003185	catalytic residues [active]
1049565003186	Uncharacterized conserved protein (DUF2280); Region: DUF2280; pfam10045
1049565003187	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410
1049565003188	Terminase-like family; Region: Terminase_6; pfam03237
1049565003189	Uncharacterized conserved protein [Function unknown]; Region: COG5323
1049565003190	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
1049565003191	HNH endonuclease; Region: HNH_3; pfam13392
1049565003192	DNA-binding domain found in transcription regulators in plants such as APETALA2 and EREBP (ethylene responsive element binding protein). In EREBPs the domain specifically binds to the 11bp GCC box of the ethylene response element (ERE), a promotor...; Region: AP2; cl00033
1049565003193	Immunoglobulin I-set domain; Region: I-set; pfam07679
1049565003194	Immunoglobulin domain; Region: Ig_2; pfam13895
1049565003195	Arc-like DNA binding domain; Region: Arc; pfam03869
1049565003196	Arc-like DNA binding domain; Region: Arc; pfam03869
1049565003197	BRO family, N-terminal domain; Region: Bro-N; smart01040
1049565003198	P22AR C-terminal domain; Region: P22_AR_C; pfam10548
1049565003199	Haemolysin XhlA; Region: XhlA; pfam10779
1049565003200	Ubiquitin-like proteins; Region: UBQ; cl00155
1049565003201	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
1049565003202	active site
1049565003203	homotetramer interface [polypeptide binding]; other site
1049565003204	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
1049565003205	dimer interface [polypeptide binding]; other site
1049565003206	Citrate synthase; Region: Citrate_synt; pfam00285
1049565003207	active site
1049565003208	citrylCoA binding site [chemical binding]; other site
1049565003209	NADH binding [chemical binding]; other site
1049565003210	cationic pore residues; other site
1049565003211	oxalacetate/citrate binding site [chemical binding]; other site
1049565003212	coenzyme A binding site [chemical binding]; other site
1049565003213	catalytic triad [active]
1049565003214	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
1049565003215	DNA binding residues [nucleotide binding]
1049565003216	dimerization interface [polypeptide binding]; other site
1049565003217	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
1049565003218	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
1049565003219	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
1049565003220	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
1049565003221	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
1049565003222	PapC N-terminal domain; Region: PapC_N; pfam13954
1049565003223	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
1049565003224	PapC C-terminal domain; Region: PapC_C; pfam13953
1049565003225	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
1049565003226	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1049565003227	Coenzyme A binding pocket [chemical binding]; other site
1049565003228	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
1049565003229	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1049565003230	putative acyl-acceptor binding pocket; other site
1049565003231	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
1049565003232	DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153
1049565003233	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1049565003234	DNA binding site [nucleotide binding]
1049565003235	lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435
1049565003236	lysine decarboxylase CadA; Provisional; Region: PRK15400
1049565003237	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
1049565003238	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
1049565003239	homodimer interface [polypeptide binding]; other site
1049565003240	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565003241	catalytic residue [active]
1049565003242	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
1049565003243	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
1049565003244	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565003245	putative substrate translocation pore; other site
1049565003246	POT family; Region: PTR2; pfam00854
1049565003247	lysyl-tRNA synthetase; Reviewed; Region: PRK12445
1049565003248	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1049565003249	dimer interface [polypeptide binding]; other site
1049565003250	putative anticodon binding site; other site
1049565003251	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
1049565003252	motif 1; other site
1049565003253	active site
1049565003254	motif 2; other site
1049565003255	motif 3; other site
1049565003256	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1049565003257	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1049565003258	Metal-binding active site; metal-binding site
1049565003259	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1049565003260	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1049565003261	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1049565003262	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1049565003263	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1049565003264	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1049565003265	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1049565003266	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1049565003267	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1049565003268	DNA binding site [nucleotide binding]
1049565003269	Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307
1049565003270	putative ligand binding site [chemical binding]; other site
1049565003271	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1049565003272	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
1049565003273	putative ligand binding site [chemical binding]; other site
1049565003274	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1049565003275	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1049565003276	Walker A/P-loop; other site
1049565003277	ATP binding site [chemical binding]; other site
1049565003278	Q-loop/lid; other site
1049565003279	ABC transporter signature motif; other site
1049565003280	Walker B; other site
1049565003281	D-loop; other site
1049565003282	H-loop/switch region; other site
1049565003283	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1049565003284	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1049565003285	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1049565003286	TM-ABC transporter signature motif; other site
1049565003287	D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417
1049565003288	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1049565003289	DNA binding site [nucleotide binding]
1049565003290	domain linker motif; other site
1049565003291	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
1049565003292	dimerization interface [polypeptide binding]; other site
1049565003293	ligand binding site [chemical binding]; other site
1049565003294	sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322
1049565003295	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1049565003296	substrate binding [chemical binding]; other site
1049565003297	active site
1049565003298	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1049565003299	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
1049565003300	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1049565003301	active site turn [active]
1049565003302	phosphorylation site [posttranslational modification]
1049565003303	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1049565003304	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
1049565003305	trimer interface; other site
1049565003306	sugar binding site [chemical binding]; other site
1049565003307	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1049565003308	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
1049565003309	putative substrate binding site [chemical binding]; other site
1049565003310	putative ATP binding site [chemical binding]; other site
1049565003311	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1049565003312	Transcriptional regulator; Region: Rrf2; cl17282
1049565003313	Protein of unknown function (DUF3302); Region: DUF3302; pfam11742
1049565003314	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
1049565003315	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1049565003316	HlyD family secretion protein; Region: HlyD_3; pfam13437
1049565003317	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1049565003318	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1049565003319	Walker A/P-loop; other site
1049565003320	ATP binding site [chemical binding]; other site
1049565003321	Q-loop/lid; other site
1049565003322	ABC transporter signature motif; other site
1049565003323	Walker B; other site
1049565003324	D-loop; other site
1049565003325	H-loop/switch region; other site
1049565003326	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1049565003327	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1049565003328	ABC-ATPase subunit  interface; other site
1049565003329	dimer interface [polypeptide binding]; other site
1049565003330	putative PBP binding regions; other site
1049565003331	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1049565003332	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1049565003333	intersubunit interface [polypeptide binding]; other site
1049565003334	Domain of unknown function (DUF3315); Region: DUF3315; pfam11776
1049565003335	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1049565003336	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
1049565003337	metal binding site [ion binding]; metal-binding site
1049565003338	putative dimer interface [polypeptide binding]; other site
1049565003339	histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437
1049565003340	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1049565003341	substrate binding pocket [chemical binding]; other site
1049565003342	membrane-bound complex binding site; other site
1049565003343	hinge residues; other site
1049565003344	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1049565003345	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1049565003346	active site
1049565003347	catalytic tetrad [active]
1049565003348	Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703
1049565003349	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1049565003350	classical (c) SDRs; Region: SDR_c; cd05233
1049565003351	NAD(P) binding site [chemical binding]; other site
1049565003352	active site
1049565003353	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
1049565003354	Sulfatase; Region: Sulfatase; pfam00884
1049565003355	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
1049565003356	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1049565003357	FeS/SAM binding site; other site
1049565003358	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
1049565003359	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1049565003360	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1049565003361	DNA binding residues [nucleotide binding]
1049565003362	dimerization interface [polypeptide binding]; other site
1049565003363	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565003364	putative substrate translocation pore; other site
1049565003365	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996
1049565003366	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
1049565003367	active site
1049565003368	Zn binding site [ion binding]; other site
1049565003369	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907
1049565003370	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1049565003371	non-specific DNA binding site [nucleotide binding]; other site
1049565003372	salt bridge; other site
1049565003373	sequence-specific DNA binding site [nucleotide binding]; other site
1049565003374	Protein of unknown function (DUF3156); Region: DUF3156; pfam11354
1049565003375	Amino acid permease; Region: AA_permease_2; pfam13520
1049565003376	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
1049565003377	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1049565003378	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1049565003379	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1049565003380	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1049565003381	NAD(P) binding site [chemical binding]; other site
1049565003382	catalytic residues [active]
1049565003383	PQQ-like domain; Region: PQQ_2; pfam13360
1049565003384	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1049565003385	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1049565003386	N-terminal plug; other site
1049565003387	ligand-binding site [chemical binding]; other site
1049565003388	phenylalanine transporter; Provisional; Region: PRK10249
1049565003389	Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825
1049565003390	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565003391	putative substrate translocation pore; other site
1049565003392	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1049565003393	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1049565003394	Metal-binding active site; metal-binding site
1049565003395	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
1049565003396	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1049565003397	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1049565003398	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1049565003399	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1049565003400	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1049565003401	DNA binding site [nucleotide binding]
1049565003402	domain linker motif; other site
1049565003403	Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284
1049565003404	dimerization interface [polypeptide binding]; other site
1049565003405	ligand binding site [chemical binding]; other site
1049565003406	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1049565003407	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1049565003408	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1049565003409	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565003410	putative substrate translocation pore; other site
1049565003411	Helix-turn-helix domain; Region: HTH_31; pfam13560
1049565003412	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
1049565003413	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1049565003414	ATP binding site [chemical binding]; other site
1049565003415	Walker B motif; other site
1049565003416	arginine finger; other site
1049565003417	Transcriptional antiterminator [Transcription]; Region: COG3933
1049565003418	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1049565003419	active pocket/dimerization site; other site
1049565003420	active site
1049565003421	phosphorylation site [posttranslational modification]
1049565003422	PRD domain; Region: PRD; pfam00874
1049565003423	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
1049565003424	A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710
1049565003425	putative active site [active]
1049565003426	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1049565003427	dimer interface [polypeptide binding]; other site
1049565003428	active site
1049565003429	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
1049565003430	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1049565003431	dimer interface [polypeptide binding]; other site
1049565003432	active site
1049565003433	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1049565003434	dimer interface [polypeptide binding]; other site
1049565003435	active site
1049565003436	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
1049565003437	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
1049565003438	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
1049565003439	active site
1049565003440	phosphorylation site [posttranslational modification]
1049565003441	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1049565003442	active site
1049565003443	active pocket/dimerization site; other site
1049565003444	phosphorylation site [posttranslational modification]
1049565003445	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
1049565003446	dimer interface [polypeptide binding]; other site
1049565003447	FMN binding site [chemical binding]; other site
1049565003448	hypothetical protein; Provisional; Region: PRK10250
1049565003449	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1049565003450	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1049565003451	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1049565003452	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
1049565003453	DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219
1049565003454	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565003455	Protein of unknown function (DUF1158); Region: DUF1158; pfam06643
1049565003456	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
1049565003457	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1049565003458	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1049565003459	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1049565003460	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
1049565003461	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1049565003462	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1049565003463	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1049565003464	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1049565003465	HlyD family secretion protein; Region: HlyD_3; pfam13437
1049565003466	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1049565003467	Predicted periplasmic protein [Function unknown]; Region: COG3698
1049565003468	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
1049565003469	gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516
1049565003470	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
1049565003471	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_8; cd08495
1049565003472	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1049565003473	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1049565003474	Protein of unknown function (DUF419); Region: DUF419; cl15265
1049565003475	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565003476	dimer interface [polypeptide binding]; other site
1049565003477	conserved gate region; other site
1049565003478	putative PBP binding loops; other site
1049565003479	ABC-ATPase subunit interface; other site
1049565003480	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
1049565003481	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1049565003482	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
1049565003483	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1049565003484	Walker A/P-loop; other site
1049565003485	ATP binding site [chemical binding]; other site
1049565003486	Q-loop/lid; other site
1049565003487	ABC transporter signature motif; other site
1049565003488	Walker B; other site
1049565003489	D-loop; other site
1049565003490	H-loop/switch region; other site
1049565003491	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1049565003492	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1049565003493	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1049565003494	Walker A/P-loop; other site
1049565003495	ATP binding site [chemical binding]; other site
1049565003496	Q-loop/lid; other site
1049565003497	ABC transporter signature motif; other site
1049565003498	Walker B; other site
1049565003499	D-loop; other site
1049565003500	H-loop/switch region; other site
1049565003501	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1049565003502	allantoate amidohydrolase; Reviewed; Region: PRK12893
1049565003503	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
1049565003504	active site
1049565003505	metal binding site [ion binding]; metal-binding site
1049565003506	dimer interface [polypeptide binding]; other site
1049565003507	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1049565003508	EamA-like transporter family; Region: EamA; cl17759
1049565003509	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1049565003510	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1049565003511	DNA-binding site [nucleotide binding]; DNA binding site
1049565003512	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1049565003513	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565003514	homodimer interface [polypeptide binding]; other site
1049565003515	catalytic residue [active]
1049565003516	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1049565003517	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1049565003518	DNA-binding site [nucleotide binding]; DNA binding site
1049565003519	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1049565003520	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565003521	homodimer interface [polypeptide binding]; other site
1049565003522	catalytic residue [active]
1049565003523	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1049565003524	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1049565003525	substrate binding pocket [chemical binding]; other site
1049565003526	membrane-bound complex binding site; other site
1049565003527	hinge residues; other site
1049565003528	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1049565003529	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565003530	dimer interface [polypeptide binding]; other site
1049565003531	conserved gate region; other site
1049565003532	putative PBP binding loops; other site
1049565003533	ABC-ATPase subunit interface; other site
1049565003534	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565003535	dimer interface [polypeptide binding]; other site
1049565003536	conserved gate region; other site
1049565003537	putative PBP binding loops; other site
1049565003538	ABC-ATPase subunit interface; other site
1049565003539	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1049565003540	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1049565003541	Walker A/P-loop; other site
1049565003542	ATP binding site [chemical binding]; other site
1049565003543	Q-loop/lid; other site
1049565003544	ABC transporter signature motif; other site
1049565003545	Walker B; other site
1049565003546	D-loop; other site
1049565003547	H-loop/switch region; other site
1049565003548	malonic semialdehyde reductase; Provisional; Region: PRK10538
1049565003549	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1049565003550	NAD(P) binding site [chemical binding]; other site
1049565003551	active site
1049565003552	hypothetical protein; Provisional; Region: PRK06062
1049565003553	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1049565003554	inhibitor-cofactor binding pocket; inhibition site
1049565003555	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565003556	catalytic residue [active]
1049565003557	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1049565003558	Helix-turn-helix domain; Region: HTH_28; pfam13518
1049565003559	Helix-turn-helix domain; Region: HTH_28; pfam13518
1049565003560	putative transposase OrfB; Reviewed; Region: PHA02517
1049565003561	HTH-like domain; Region: HTH_21; pfam13276
1049565003562	Integrase core domain; Region: rve; pfam00665
1049565003563	Integrase core domain; Region: rve_2; pfam13333
1049565003564	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1049565003565	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1049565003566	Walker A/P-loop; other site
1049565003567	ATP binding site [chemical binding]; other site
1049565003568	Q-loop/lid; other site
1049565003569	ABC transporter signature motif; other site
1049565003570	Walker B; other site
1049565003571	D-loop; other site
1049565003572	H-loop/switch region; other site
1049565003573	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1049565003574	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1049565003575	Walker A/P-loop; other site
1049565003576	ATP binding site [chemical binding]; other site
1049565003577	Q-loop/lid; other site
1049565003578	ABC transporter signature motif; other site
1049565003579	Walker B; other site
1049565003580	D-loop; other site
1049565003581	H-loop/switch region; other site
1049565003582	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1049565003583	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1049565003584	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565003585	dimer interface [polypeptide binding]; other site
1049565003586	conserved gate region; other site
1049565003587	ABC-ATPase subunit interface; other site
1049565003588	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1049565003589	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565003590	dimer interface [polypeptide binding]; other site
1049565003591	conserved gate region; other site
1049565003592	putative PBP binding loops; other site
1049565003593	ABC-ATPase subunit interface; other site
1049565003594	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1049565003595	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
1049565003596	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1049565003597	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1049565003598	choline dehydrogenase; Validated; Region: PRK02106
1049565003599	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1049565003600	betaine aldehyde dehydrogenase; Provisional; Region: PRK13252
1049565003601	NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090
1049565003602	tetrameric interface [polypeptide binding]; other site
1049565003603	NAD binding site [chemical binding]; other site
1049565003604	catalytic residues [active]
1049565003605	transcriptional regulator BetI; Validated; Region: PRK00767
1049565003606	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1049565003607	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1049565003608	choline transport protein BetT; Provisional; Region: PRK09928
1049565003609	C-lysozyme inhibitor; Provisional; Region: PRK09993
1049565003610	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1049565003611	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1049565003612	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1049565003613	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565003614	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1049565003615	dimerization interface [polypeptide binding]; other site
1049565003616	substrate binding pocket [chemical binding]; other site
1049565003617	Pou domain - N-terminal to homeobox domain; Region: Pou; cl02582
1049565003618	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1049565003619	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
1049565003620	C-terminal domain interface [polypeptide binding]; other site
1049565003621	GSH binding site (G-site) [chemical binding]; other site
1049565003622	dimer interface [polypeptide binding]; other site
1049565003623	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
1049565003624	dimer interface [polypeptide binding]; other site
1049565003625	N-terminal domain interface [polypeptide binding]; other site
1049565003626	putative substrate binding pocket (H-site) [chemical binding]; other site
1049565003627	short chain dehydrogenase; Provisional; Region: PRK06114
1049565003628	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1049565003629	NAD(P) binding site [chemical binding]; other site
1049565003630	active site
1049565003631	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1049565003632	meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366
1049565003633	NAD binding site [chemical binding]; other site
1049565003634	homotetramer interface [polypeptide binding]; other site
1049565003635	homodimer interface [polypeptide binding]; other site
1049565003636	active site
1049565003637	substrate binding site [chemical binding]; other site
1049565003638	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1049565003639	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1049565003640	TM-ABC transporter signature motif; other site
1049565003641	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1049565003642	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1049565003643	Walker A/P-loop; other site
1049565003644	ATP binding site [chemical binding]; other site
1049565003645	Q-loop/lid; other site
1049565003646	ABC transporter signature motif; other site
1049565003647	Walker B; other site
1049565003648	D-loop; other site
1049565003649	H-loop/switch region; other site
1049565003650	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1049565003651	Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; cl02395
1049565003652	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1049565003653	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1049565003654	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
1049565003655	bacterial glycerol kinase 2-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK2_bacteria; cd07791
1049565003656	N- and C-terminal domain interface [polypeptide binding]; other site
1049565003657	active site
1049565003658	MgATP binding site [chemical binding]; other site
1049565003659	catalytic site [active]
1049565003660	metal binding site [ion binding]; metal-binding site
1049565003661	putative homotetramer interface [polypeptide binding]; other site
1049565003662	putative homodimer interface [polypeptide binding]; other site
1049565003663	glycerol binding site [chemical binding]; other site
1049565003664	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1049565003665	MarR family; Region: MarR_2; cl17246
1049565003666	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1049565003667	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1049565003668	TPP-binding site [chemical binding]; other site
1049565003669	dimer interface [polypeptide binding]; other site
1049565003670	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
1049565003671	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1049565003672	PYR/PP interface [polypeptide binding]; other site
1049565003673	dimer interface [polypeptide binding]; other site
1049565003674	TPP binding site [chemical binding]; other site
1049565003675	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1049565003676	phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251
1049565003677	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
1049565003678	outer membrane receptor FepA; Provisional; Region: PRK13524
1049565003679	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1049565003680	N-terminal plug; other site
1049565003681	ligand-binding site [chemical binding]; other site
1049565003682	enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439
1049565003683	Domain of unknown function (DUF3327); Region: DUF3327; pfam11806
1049565003684	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1049565003685	MbtH-like protein; Region: MbtH; smart00923
1049565003686	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
1049565003687	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1049565003688	acyl-activating enzyme (AAE) consensus motif; other site
1049565003689	AMP binding site [chemical binding]; other site
1049565003690	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1049565003691	iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253
1049565003692	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1049565003693	Walker A/P-loop; other site
1049565003694	ATP binding site [chemical binding]; other site
1049565003695	Q-loop/lid; other site
1049565003696	ABC transporter signature motif; other site
1049565003697	Walker B; other site
1049565003698	D-loop; other site
1049565003699	H-loop/switch region; other site
1049565003700	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1049565003701	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1049565003702	ABC-ATPase subunit  interface; other site
1049565003703	dimer interface [polypeptide binding]; other site
1049565003704	putative PBP binding regions; other site
1049565003705	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1049565003706	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1049565003707	ABC-ATPase subunit  interface; other site
1049565003708	dimer interface [polypeptide binding]; other site
1049565003709	putative PBP binding regions; other site
1049565003710	enterobactin exporter EntS; Provisional; Region: PRK10489
1049565003711	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565003712	putative substrate translocation pore; other site
1049565003713	iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957
1049565003714	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1049565003715	siderophore binding site; other site
1049565003716	isochorismate synthase EntC; Provisional; Region: PRK15016
1049565003717	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1049565003718	enterobactin synthase subunit E; Provisional; Region: entE; PRK10946
1049565003719	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
1049565003720	acyl-activating enzyme (AAE) consensus motif; other site
1049565003721	active site
1049565003722	AMP binding site [chemical binding]; other site
1049565003723	substrate binding site [chemical binding]; other site
1049565003724	Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013
1049565003725	hydrophobic substrate binding pocket; other site
1049565003726	Isochorismatase family; Region: Isochorismatase; pfam00857
1049565003727	active site
1049565003728	conserved cis-peptide bond; other site
1049565003729	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
1049565003730	2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220
1049565003731	2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331
1049565003732	putative NAD(P) binding site [chemical binding]; other site
1049565003733	active site
1049565003734	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1049565003735	CoenzymeA binding site [chemical binding]; other site
1049565003736	subunit interaction site [polypeptide binding]; other site
1049565003737	PHB binding site; other site
1049565003738	carbon starvation protein A; Provisional; Region: PRK15015
1049565003739	Carbon starvation protein CstA; Region: CstA; pfam02554
1049565003740	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
1049565003741	Uncharacterized small protein [Function unknown]; Region: COG2879
1049565003742	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1049565003743	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1049565003744	salt bridge; other site
1049565003745	non-specific DNA binding site [nucleotide binding]; other site
1049565003746	sequence-specific DNA binding site [nucleotide binding]; other site
1049565003747	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
1049565003748	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1049565003749	classical (c) SDRs; Region: SDR_c; cd05233
1049565003750	NAD(P) binding site [chemical binding]; other site
1049565003751	active site
1049565003752	potential frameshift: common BLAST hit: gi|288936600|ref|YP_003440659.1| glycerol dehydrogenase
1049565003753	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1049565003754	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1049565003755	Walker A/P-loop; other site
1049565003756	ATP binding site [chemical binding]; other site
1049565003757	Q-loop/lid; other site
1049565003758	ABC transporter signature motif; other site
1049565003759	Walker B; other site
1049565003760	D-loop; other site
1049565003761	H-loop/switch region; other site
1049565003762	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1049565003763	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1049565003764	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1049565003765	TM-ABC transporter signature motif; other site
1049565003766	Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305
1049565003767	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1049565003768	putative ligand binding site [chemical binding]; other site
1049565003769	Uncharacterized conserved protein [Function unknown]; Region: COG5276
1049565003770	methylthioribose kinase; Reviewed; Region: mtnK; PRK09550
1049565003771	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
1049565003772	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
1049565003773	glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173
1049565003774	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
1049565003775	catalytic core [active]
1049565003776	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
1049565003777	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
1049565003778	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565003779	putative substrate translocation pore; other site
1049565003780	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1049565003781	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
1049565003782	active site
1049565003783	dimerization interface [polypeptide binding]; other site
1049565003784	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1049565003785	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1049565003786	DNA binding site [nucleotide binding]
1049565003787	domain linker motif; other site
1049565003788	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278
1049565003789	putative dimerization interface [polypeptide binding]; other site
1049565003790	putative ligand binding site [chemical binding]; other site
1049565003791	cytosine deaminase; Provisional; Region: PRK09230
1049565003792	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
1049565003793	active site
1049565003794	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
1049565003795	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1049565003796	cytosine permease; Provisional; Region: codB; PRK11017
1049565003797	Na binding site [ion binding]; other site
1049565003798	methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220
1049565003799	intersubunit interface [polypeptide binding]; other site
1049565003800	active site
1049565003801	Zn2+ binding site [ion binding]; other site
1049565003802	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
1049565003803	L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802
1049565003804	putative N- and C-terminal domain interface [polypeptide binding]; other site
1049565003805	putative active site [active]
1049565003806	MgATP binding site [chemical binding]; other site
1049565003807	catalytic site [active]
1049565003808	metal binding site [ion binding]; metal-binding site
1049565003809	putative xylulose binding site [chemical binding]; other site
1049565003810	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1049565003811	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171
1049565003812	putative ligand binding site [chemical binding]; other site
1049565003813	putative NAD binding site [chemical binding]; other site
1049565003814	catalytic site [active]
1049565003815	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1049565003816	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1049565003817	substrate binding site [chemical binding]; other site
1049565003818	ATP binding site [chemical binding]; other site
1049565003819	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1049565003820	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1049565003821	TM-ABC transporter signature motif; other site
1049565003822	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1049565003823	TM-ABC transporter signature motif; other site
1049565003824	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1049565003825	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1049565003826	Walker A/P-loop; other site
1049565003827	ATP binding site [chemical binding]; other site
1049565003828	Q-loop/lid; other site
1049565003829	ABC transporter signature motif; other site
1049565003830	Walker B; other site
1049565003831	D-loop; other site
1049565003832	H-loop/switch region; other site
1049565003833	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1049565003834	Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305
1049565003835	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1049565003836	putative ligand binding site [chemical binding]; other site
1049565003837	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
1049565003838	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
1049565003839	molybdopterin cofactor binding site [chemical binding]; other site
1049565003840	substrate binding site [chemical binding]; other site
1049565003841	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
1049565003842	molybdopterin cofactor binding site; other site
1049565003843	ARD/ARD' family; Region: ARD; pfam03079
1049565003844	Cupin domain; Region: Cupin_2; cl17218
1049565003845	2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691
1049565003846	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1049565003847	motif II; other site
1049565003848	methionine aminotransferase; Validated; Region: PRK09082
1049565003849	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1049565003850	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565003851	homodimer interface [polypeptide binding]; other site
1049565003852	catalytic residue [active]
1049565003853	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
1049565003854	ParB-like nuclease domain; Region: ParBc; pfam02195
1049565003855	Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969
1049565003856	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1049565003857	Active Sites [active]
1049565003858	Domain of unknown function (DUF3440); Region: DUF3440; pfam11922
1049565003859	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482
1049565003860	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565003861	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1049565003862	dimerization interface [polypeptide binding]; other site
1049565003863	disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657
1049565003864	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
1049565003865	dimerization domain [polypeptide binding]; other site
1049565003866	dimer interface [polypeptide binding]; other site
1049565003867	catalytic residues [active]
1049565003868	alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382
1049565003869	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1049565003870	dimer interface [polypeptide binding]; other site
1049565003871	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1049565003872	catalytic triad [active]
1049565003873	peroxidatic and resolving cysteines [active]
1049565003874	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
1049565003875	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
1049565003876	catalytic residue [active]
1049565003877	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
1049565003878	catalytic residues [active]
1049565003879	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1049565003880	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1049565003881	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1049565003882	Ligand Binding Site [chemical binding]; other site
1049565003883	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
1049565003884	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1049565003885	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
1049565003886	B1 nucleotide binding pocket [chemical binding]; other site
1049565003887	B2 nucleotide binding pocket [chemical binding]; other site
1049565003888	CAS motifs; other site
1049565003889	active site
1049565003890	C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654
1049565003891	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
1049565003892	phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045
1049565003893	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1049565003894	DNA-binding site [nucleotide binding]; DNA binding site
1049565003895	RNA-binding motif; other site
1049565003896	chromosome condensation membrane protein; Provisional; Region: PRK14196
1049565003897	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1049565003898	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
1049565003899	putative active site [active]
1049565003900	catalytic triad [active]
1049565003901	putative dimer interface [polypeptide binding]; other site
1049565003902	twin arginine translocase protein E; Validated; Region: tatE; PRK03625
1049565003903	lipoyl synthase; Provisional; Region: PRK05481
1049565003904	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1049565003905	FeS/SAM binding site; other site
1049565003906	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482
1049565003907	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565003908	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
1049565003909	substrate binding pocket [chemical binding]; other site
1049565003910	dimerization interface [polypeptide binding]; other site
1049565003911	lipoate-protein ligase B; Provisional; Region: PRK14342
1049565003912	hypothetical protein; Provisional; Region: PRK04998
1049565003913	D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793
1049565003914	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1049565003915	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
1049565003916	rare lipoprotein A; Provisional; Region: PRK10672
1049565003917	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
1049565003918	Sporulation related domain; Region: SPOR; pfam05036
1049565003919	cell wall shape-determining protein; Provisional; Region: PRK10794
1049565003920	penicillin-binding protein 2; Provisional; Region: PRK10795
1049565003921	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1049565003922	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1049565003923	rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246
1049565003924	Oligomerisation domain; Region: Oligomerisation; cl00519
1049565003925	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1049565003926	catalytic core [active]
1049565003927	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
1049565003928	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1049565003929	active site
1049565003930	(T/H)XGH motif; other site
1049565003931	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
1049565003932	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1049565003933	LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796
1049565003934	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1049565003935	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1049565003936	HIGH motif; other site
1049565003937	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1049565003938	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1049565003939	active site
1049565003940	KMSKS motif; other site
1049565003941	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1049565003942	tRNA binding surface [nucleotide binding]; other site
1049565003943	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1049565003944	hypothetical protein; Provisional; Region: PRK11032
1049565003945	haemagglutination activity domain; Region: Haemagg_act; pfam05860
1049565003946	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
1049565003947	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
1049565003948	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
1049565003949	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1049565003950	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1049565003951	Walker A/P-loop; other site
1049565003952	ATP binding site [chemical binding]; other site
1049565003953	Q-loop/lid; other site
1049565003954	ABC transporter signature motif; other site
1049565003955	Walker B; other site
1049565003956	D-loop; other site
1049565003957	H-loop/switch region; other site
1049565003958	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1049565003959	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565003960	dimer interface [polypeptide binding]; other site
1049565003961	conserved gate region; other site
1049565003962	putative PBP binding loops; other site
1049565003963	ABC-ATPase subunit interface; other site
1049565003964	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1049565003965	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565003966	dimer interface [polypeptide binding]; other site
1049565003967	conserved gate region; other site
1049565003968	putative PBP binding loops; other site
1049565003969	ABC-ATPase subunit interface; other site
1049565003970	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
1049565003971	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1049565003972	substrate binding pocket [chemical binding]; other site
1049565003973	membrane-bound complex binding site; other site
1049565003974	hinge residues; other site
1049565003975	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
1049565003976	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
1049565003977	putative active site [active]
1049565003978	catalytic triad [active]
1049565003979	putative dimer interface [polypeptide binding]; other site
1049565003980	magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094
1049565003981	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1049565003982	Transporter associated domain; Region: CorC_HlyC; smart01091
1049565003983	metal-binding heat shock protein; Provisional; Region: PRK00016
1049565003984	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1049565003985	PhoH-like protein; Region: PhoH; pfam02562
1049565003986	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
1049565003987	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1049565003988	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1049565003989	FeS/SAM binding site; other site
1049565003990	TRAM domain; Region: TRAM; pfam01938
1049565003991	2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020
1049565003992	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1049565003993	asparagine synthetase B; Provisional; Region: asnB; PRK09431
1049565003994	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
1049565003995	active site
1049565003996	dimer interface [polypeptide binding]; other site
1049565003997	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1049565003998	Ligand Binding Site [chemical binding]; other site
1049565003999	Molecular Tunnel; other site
1049565004000	UMP phosphatase; Provisional; Region: PRK10444
1049565004001	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1049565004002	active site
1049565004003	motif I; other site
1049565004004	motif II; other site
1049565004005	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1049565004006	MarR family; Region: MarR; pfam01047
1049565004007	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1049565004008	ROK family; Region: ROK; pfam00480
1049565004009	N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221
1049565004010	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
1049565004011	active site
1049565004012	dimer interface [polypeptide binding]; other site
1049565004013	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1049565004014	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
1049565004015	active site
1049565004016	trimer interface [polypeptide binding]; other site
1049565004017	allosteric site; other site
1049565004018	active site lid [active]
1049565004019	hexamer (dimer of trimers) interface [polypeptide binding]; other site
1049565004020	PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255
1049565004021	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1049565004022	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1049565004023	active site turn [active]
1049565004024	phosphorylation site [posttranslational modification]
1049565004025	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
1049565004026	HPr interaction site; other site
1049565004027	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1049565004028	active site
1049565004029	phosphorylation site [posttranslational modification]
1049565004030	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
1049565004031	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1049565004032	active site
1049565004033	HIGH motif; other site
1049565004034	nucleotide binding site [chemical binding]; other site
1049565004035	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
1049565004036	KMSKS motif; other site
1049565004037	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
1049565004038	outer membrane porin, OprD family; Region: OprD; pfam03573
1049565004039	YbfN-like lipoprotein; Region: YbfN; pfam13982
1049565004040	ferric uptake regulator; Provisional; Region: fur; PRK09462
1049565004041	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1049565004042	metal binding site 2 [ion binding]; metal-binding site
1049565004043	putative DNA binding helix; other site
1049565004044	metal binding site 1 [ion binding]; metal-binding site
1049565004045	dimer interface [polypeptide binding]; other site
1049565004046	structural Zn2+ binding site [ion binding]; other site
1049565004047	flavodoxin FldA; Validated; Region: PRK09267
1049565004048	LexA regulated protein; Provisional; Region: PRK11675
1049565004049	acyl-CoA esterase; Provisional; Region: PRK10673
1049565004050	PGAP1-like protein; Region: PGAP1; pfam07819
1049565004051	replication initiation regulator SeqA; Provisional; Region: PRK11187
1049565004052	phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132
1049565004053	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
1049565004054	active site
1049565004055	substrate binding site [chemical binding]; other site
1049565004056	metal binding site [ion binding]; metal-binding site
1049565004057	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
1049565004058	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1049565004059	active site
1049565004060	phosphorylation site [posttranslational modification]
1049565004061	intermolecular recognition site; other site
1049565004062	dimerization interface [polypeptide binding]; other site
1049565004063	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1049565004064	DNA binding site [nucleotide binding]
1049565004065	sensor protein KdpD; Provisional; Region: PRK10490
1049565004066	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
1049565004067	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
1049565004068	Ligand Binding Site [chemical binding]; other site
1049565004069	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
1049565004070	GAF domain; Region: GAF_3; pfam13492
1049565004071	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1049565004072	dimer interface [polypeptide binding]; other site
1049565004073	phosphorylation site [posttranslational modification]
1049565004074	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1049565004075	ATP binding site [chemical binding]; other site
1049565004076	Mg2+ binding site [ion binding]; other site
1049565004077	G-X-G motif; other site
1049565004078	potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315
1049565004079	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
1049565004080	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1049565004081	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
1049565004082	Protein of unknown function (DUF2517); Region: DUF2517; pfam10725
1049565004083	deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674
1049565004084	DNA photolyase; Region: DNA_photolyase; pfam00875
1049565004085	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
1049565004086	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565004087	putative substrate translocation pore; other site
1049565004088	POT family; Region: PTR2; pfam00854
1049565004089	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1049565004090	metal-binding protein; Provisional; Region: PRK10799
1049565004091	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
1049565004092	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
1049565004093	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
1049565004094	LamB/YcsF family protein; Provisional; Region: PRK05406
1049565004095	Protein of unknown function (DUF969); Region: DUF969; pfam06149
1049565004096	Predicted membrane protein [Function unknown]; Region: COG3817
1049565004097	Protein of unknown function (DUF979); Region: DUF979; pfam06166
1049565004098	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
1049565004099	putative substrate binding pocket [chemical binding]; other site
1049565004100	AC domain interface; other site
1049565004101	catalytic triad [active]
1049565004102	AB domain interface; other site
1049565004103	interchain disulfide; other site
1049565004104	endonuclease VIII; Provisional; Region: PRK10445
1049565004105	N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965
1049565004106	DNA binding site [nucleotide binding]
1049565004107	catalytic residue [active]
1049565004108	putative catalytic residues [active]
1049565004109	H2TH interface [polypeptide binding]; other site
1049565004110	intercalation triad [nucleotide binding]; other site
1049565004111	substrate specificity determining residue; other site
1049565004112	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1049565004113	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1049565004114	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
1049565004115	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
1049565004116	dimer interface [polypeptide binding]; other site
1049565004117	active site
1049565004118	citrylCoA binding site [chemical binding]; other site
1049565004119	NADH binding [chemical binding]; other site
1049565004120	cationic pore residues; other site
1049565004121	oxalacetate/citrate binding site [chemical binding]; other site
1049565004122	coenzyme A binding site [chemical binding]; other site
1049565004123	catalytic triad [active]
1049565004124	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
1049565004125	Iron-sulfur protein interface; other site
1049565004126	proximal quinone binding site [chemical binding]; other site
1049565004127	SdhD (CybS) interface [polypeptide binding]; other site
1049565004128	proximal heme binding site [chemical binding]; other site
1049565004129	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
1049565004130	SdhC subunit interface [polypeptide binding]; other site
1049565004131	proximal heme binding site [chemical binding]; other site
1049565004132	cardiolipin binding site; other site
1049565004133	Iron-sulfur protein interface; other site
1049565004134	proximal quinone binding site [chemical binding]; other site
1049565004135	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958
1049565004136	L-aspartate oxidase; Provisional; Region: PRK06175
1049565004137	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1049565004138	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
1049565004139	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1049565004140	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
1049565004141	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
1049565004142	TPP-binding site [chemical binding]; other site
1049565004143	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
1049565004144	dimer interface [polypeptide binding]; other site
1049565004145	PYR/PP interface [polypeptide binding]; other site
1049565004146	TPP binding site [chemical binding]; other site
1049565004147	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
1049565004148	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1049565004149	E3 interaction surface; other site
1049565004150	lipoyl attachment site [posttranslational modification]; other site
1049565004151	e3 binding domain; Region: E3_binding; pfam02817
1049565004152	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1049565004153	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
1049565004154	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
1049565004155	CoA-ligase; Region: Ligase_CoA; pfam00549
1049565004156	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
1049565004157	CoA binding domain; Region: CoA_binding; smart00881
1049565004158	CoA-ligase; Region: Ligase_CoA; pfam00549
1049565004159	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
1049565004160	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
1049565004161	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003
1049565004162	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1049565004163	Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039
1049565004164	hypothetical protein; Provisional; Region: PRK10588
1049565004165	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1049565004166	active site
1049565004167	colicin uptake protein TolQ; Provisional; Region: PRK10801
1049565004168	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1049565004169	colicin uptake protein TolR; Provisional; Region: PRK11024
1049565004170	cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510
1049565004171	TolA C-terminal; Region: TolA; pfam06519
1049565004172	translocation protein TolB; Provisional; Region: tolB; PRK03629
1049565004173	TolB amino-terminal domain; Region: TolB_N; pfam04052
1049565004174	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1049565004175	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1049565004176	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1049565004177	peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802
1049565004178	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1049565004179	ligand binding site [chemical binding]; other site
1049565004180	tol-pal system protein YbgF; Provisional; Region: PRK10803
1049565004181	Tetratricopeptide repeat; Region: TPR_6; pfam13174
1049565004182	Tetratricopeptide repeat; Region: TPR_6; pfam13174
1049565004183	quinolinate synthetase; Provisional; Region: PRK09375
1049565004184	nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397
1049565004185	zinc transporter ZitB; Provisional; Region: PRK03557
1049565004186	YbgS-like protein; Region: YbgS; pfam13985
1049565004187	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
1049565004188	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1049565004189	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1049565004190	catalytic core [active]
1049565004191	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1049565004192	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
1049565004193	active site
1049565004194	catalytic residues [active]
1049565004195	galactokinase; Provisional; Region: PRK05101
1049565004196	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
1049565004197	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1049565004198	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1049565004199	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720
1049565004200	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
1049565004201	dimer interface [polypeptide binding]; other site
1049565004202	active site
1049565004203	UDP-galactose-4-epimerase; Provisional; Region: PRK10675
1049565004204	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1049565004205	NAD binding site [chemical binding]; other site
1049565004206	homodimer interface [polypeptide binding]; other site
1049565004207	active site
1049565004208	substrate binding site [chemical binding]; other site
1049565004209	putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938
1049565004210	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1049565004211	Walker A/P-loop; other site
1049565004212	ATP binding site [chemical binding]; other site
1049565004213	Q-loop/lid; other site
1049565004214	ABC transporter signature motif; other site
1049565004215	Walker B; other site
1049565004216	D-loop; other site
1049565004217	H-loop/switch region; other site
1049565004218	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1049565004219	Walker A/P-loop; other site
1049565004220	ATP binding site [chemical binding]; other site
1049565004221	Q-loop/lid; other site
1049565004222	ABC transporter signature motif; other site
1049565004223	Walker B; other site
1049565004224	D-loop; other site
1049565004225	H-loop/switch region; other site
1049565004226	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
1049565004227	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
1049565004228	molybdenum-pterin binding domain; Region: Mop; TIGR00638
1049565004229	TOBE domain; Region: TOBE; pfam03459
1049565004230	Protein of unknown function (DUF2592); Region: DUF2592; pfam10766
1049565004231	molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677
1049565004232	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1049565004233	substrate binding pocket [chemical binding]; other site
1049565004234	membrane-bound complex binding site; other site
1049565004235	hinge residues; other site
1049565004236	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1049565004237	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565004238	dimer interface [polypeptide binding]; other site
1049565004239	conserved gate region; other site
1049565004240	putative PBP binding loops; other site
1049565004241	ABC-ATPase subunit interface; other site
1049565004242	molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144
1049565004243	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1049565004244	Walker A/P-loop; other site
1049565004245	ATP binding site [chemical binding]; other site
1049565004246	Q-loop/lid; other site
1049565004247	ABC transporter signature motif; other site
1049565004248	Walker B; other site
1049565004249	D-loop; other site
1049565004250	H-loop/switch region; other site
1049565004251	TOBE domain; Region: TOBE; cl01440
1049565004252	pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530
1049565004253	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1049565004254	active site
1049565004255	motif I; other site
1049565004256	motif II; other site
1049565004257	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1049565004258	6-phosphogluconolactonase; Provisional; Region: PRK11028
1049565004259	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
1049565004260	Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798
1049565004261	Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798
1049565004262	Sensors of blue-light using FAD; Region: BLUF; smart01034
1049565004263	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1049565004264	transcriptional regulator MirA; Provisional; Region: PRK15043
1049565004265	Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763
1049565004266	DNA binding residues [nucleotide binding]
1049565004267	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1049565004268	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1049565004269	DNA binding residues [nucleotide binding]
1049565004270	dimerization interface [polypeptide binding]; other site
1049565004271	Putative biofilm-dependent modulation protein; Region: BDM; cl11581
1049565004272	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
1049565004273	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1049565004274	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1049565004275	HlyD family secretion protein; Region: HlyD_3; pfam13437
1049565004276	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1049565004277	Ligand Binding Site [chemical binding]; other site
1049565004278	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
1049565004279	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1049565004280	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1049565004281	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1049565004282	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1049565004283	motif I; other site
1049565004284	motif II; other site
1049565004285	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1049565004286	acyl-CoA thioesterase; Provisional; Region: PRK10531
1049565004287	putative pectinesterase; Region: PLN02432; cl01911
1049565004288	imidazolonepropionase; Validated; Region: PRK09356
1049565004289	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
1049565004290	active site
1049565004291	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
1049565004292	putative active site [active]
1049565004293	putative metal binding site [ion binding]; other site
1049565004294	histidine utilization repressor; Provisional; Region: PRK14999
1049565004295	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1049565004296	DNA-binding site [nucleotide binding]; DNA binding site
1049565004297	UTRA domain; Region: UTRA; pfam07702
1049565004298	urocanate hydratase; Provisional; Region: PRK05414
1049565004299	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
1049565004300	active sites [active]
1049565004301	tetramer interface [polypeptide binding]; other site
1049565004302	putative proline-specific permease; Provisional; Region: proY; PRK10580
1049565004303	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1049565004304	substrate binding site [chemical binding]; other site
1049565004305	adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986
1049565004306	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1049565004307	inhibitor-cofactor binding pocket; inhibition site
1049565004308	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565004309	catalytic residue [active]
1049565004310	biotin synthase; Provisional; Region: PRK15108
1049565004311	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1049565004312	FeS/SAM binding site; other site
1049565004313	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
1049565004314	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
1049565004315	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1049565004316	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1049565004317	catalytic residue [active]
1049565004318	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1049565004319	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1049565004320	S-adenosylmethionine binding site [chemical binding]; other site
1049565004321	AAA domain; Region: AAA_26; pfam13500
1049565004322	Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109
1049565004323	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1049565004324	ATP binding site [chemical binding]; other site
1049565004325	Walker A/P-loop; other site
1049565004326	ABC transporter; Region: ABC_tran; pfam00005
1049565004327	Q-loop/lid; other site
1049565004328	ABC transporter signature motif; other site
1049565004329	Walker B; other site
1049565004330	D-loop; other site
1049565004331	H-loop/switch region; other site
1049565004332	excinuclease ABC subunit B; Provisional; Region: PRK05298
1049565004333	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1049565004334	ATP binding site [chemical binding]; other site
1049565004335	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1049565004336	nucleotide binding region [chemical binding]; other site
1049565004337	ATP-binding site [chemical binding]; other site
1049565004338	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1049565004339	UvrB/uvrC motif; Region: UVR; pfam02151
1049565004340	sensor protein BasS/PmrB; Provisional; Region: PRK10755
1049565004341	HAMP domain; Region: HAMP; pfam00672
1049565004342	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1049565004343	ATP binding site [chemical binding]; other site
1049565004344	Mg2+ binding site [ion binding]; other site
1049565004345	G-X-G motif; other site
1049565004346	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
1049565004347	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1049565004348	active site
1049565004349	phosphorylation site [posttranslational modification]
1049565004350	intermolecular recognition site; other site
1049565004351	dimerization interface [polypeptide binding]; other site
1049565004352	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1049565004353	DNA binding site [nucleotide binding]
1049565004354	putative metal dependent hydrolase; Provisional; Region: PRK11598
1049565004355	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
1049565004356	Sulfatase; Region: Sulfatase; pfam00884
1049565004357	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
1049565004358	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
1049565004359	phosphate binding site [ion binding]; other site
1049565004360	putative substrate binding pocket [chemical binding]; other site
1049565004361	dimer interface [polypeptide binding]; other site
1049565004362	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
1049565004363	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1049565004364	FeS/SAM binding site; other site
1049565004365	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1049565004366	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1049565004367	MPT binding site; other site
1049565004368	trimer interface [polypeptide binding]; other site
1049565004369	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
1049565004370	trimer interface [polypeptide binding]; other site
1049565004371	dimer interface [polypeptide binding]; other site
1049565004372	putative active site [active]
1049565004373	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
1049565004374	MoaE interaction surface [polypeptide binding]; other site
1049565004375	MoeB interaction surface [polypeptide binding]; other site
1049565004376	thiocarboxylated glycine; other site
1049565004377	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
1049565004378	MoaE homodimer interface [polypeptide binding]; other site
1049565004379	MoaD interaction [polypeptide binding]; other site
1049565004380	active site residues [active]
1049565004381	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
1049565004382	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
1049565004383	Predicted integral membrane protein [Function unknown]; Region: COG0392
1049565004384	cardiolipin synthase 2; Provisional; Region: PRK11263
1049565004385	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1049565004386	putative active site [active]
1049565004387	catalytic site [active]
1049565004388	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
1049565004389	putative active site [active]
1049565004390	catalytic site [active]
1049565004391	Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568
1049565004392	putative catalytic site [active]
1049565004393	putative metal binding site [ion binding]; other site
1049565004394	putative phosphate binding site [ion binding]; other site
1049565004395	Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076
1049565004396	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1049565004397	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1049565004398	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1049565004399	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
1049565004400	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1049565004401	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1049565004402	Walker A/P-loop; other site
1049565004403	ATP binding site [chemical binding]; other site
1049565004404	Q-loop/lid; other site
1049565004405	ABC transporter signature motif; other site
1049565004406	Walker B; other site
1049565004407	D-loop; other site
1049565004408	H-loop/switch region; other site
1049565004409	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1049565004410	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1049565004411	Walker A/P-loop; other site
1049565004412	ATP binding site [chemical binding]; other site
1049565004413	Q-loop/lid; other site
1049565004414	ABC transporter signature motif; other site
1049565004415	Walker B; other site
1049565004416	D-loop; other site
1049565004417	H-loop/switch region; other site
1049565004418	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
1049565004419	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1049565004420	HlyD family secretion protein; Region: HlyD_3; pfam13437
1049565004421	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552
1049565004422	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1049565004423	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
1049565004424	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1049565004425	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565004426	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1049565004427	dimerization interface [polypeptide binding]; other site
1049565004428	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565004429	D-galactonate transporter; Region: 2A0114; TIGR00893
1049565004430	putative substrate translocation pore; other site
1049565004431	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565004432	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1049565004433	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1049565004434	NAD(P) binding site [chemical binding]; other site
1049565004435	active site
1049565004436	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1049565004437	TPP-binding site [chemical binding]; other site
1049565004438	dimer interface [polypeptide binding]; other site
1049565004439	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
1049565004440	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1049565004441	PYR/PP interface [polypeptide binding]; other site
1049565004442	dimer interface [polypeptide binding]; other site
1049565004443	TPP binding site [chemical binding]; other site
1049565004444	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1049565004445	helicase 45; Provisional; Region: PTZ00424
1049565004446	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1049565004447	ATP binding site [chemical binding]; other site
1049565004448	Mg++ binding site [ion binding]; other site
1049565004449	motif III; other site
1049565004450	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1049565004451	nucleotide binding region [chemical binding]; other site
1049565004452	ATP-binding site [chemical binding]; other site
1049565004453	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
1049565004454	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1049565004455	DEAD_2; Region: DEAD_2; pfam06733
1049565004456	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1049565004457	glycosyl transferase family protein; Provisional; Region: PRK08136
1049565004458	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1049565004459	Protein of unknown function (DUF1471); Region: DUF1471; cl11507
1049565004460	hypothetical protein; Provisional; Region: PRK11019
1049565004461	Protein of unknown function (DUF1471); Region: DUF1471; cl11507
1049565004462	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1049565004463	Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971
1049565004464	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1049565004465	S-adenosylmethionine binding site [chemical binding]; other site
1049565004466	putative mechanosensitive channel protein; Provisional; Region: PRK11465
1049565004467	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1049565004468	glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493
1049565004469	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1049565004470	Walker A/P-loop; other site
1049565004471	ATP binding site [chemical binding]; other site
1049565004472	Q-loop/lid; other site
1049565004473	ABC transporter signature motif; other site
1049565004474	Walker B; other site
1049565004475	D-loop; other site
1049565004476	H-loop/switch region; other site
1049565004477	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1049565004478	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565004479	dimer interface [polypeptide binding]; other site
1049565004480	conserved gate region; other site
1049565004481	putative PBP binding loops; other site
1049565004482	ABC-ATPase subunit interface; other site
1049565004483	glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495
1049565004484	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1049565004485	substrate binding pocket [chemical binding]; other site
1049565004486	membrane-bound complex binding site; other site
1049565004487	hinge residues; other site
1049565004488	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1049565004489	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1049565004490	dimerization interface [polypeptide binding]; other site
1049565004491	DPS ferroxidase diiron center [ion binding]; other site
1049565004492	ion pore; other site
1049565004493	threonine and homoserine efflux system; Provisional; Region: PRK10532
1049565004494	EamA-like transporter family; Region: EamA; pfam00892
1049565004495	outer membrane protein X; Provisional; Region: ompX; PRK09408
1049565004496	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
1049565004497	Sulfatase; Region: Sulfatase; pfam00884
1049565004498	manganese transport regulator MntR; Provisional; Region: PRK11050
1049565004499	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
1049565004500	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
1049565004501	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1049565004502	Putative anion permease YbiR.  Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117
1049565004503	transmembrane helices; other site
1049565004504	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
1049565004505	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1049565004506	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1049565004507	DNA-binding site [nucleotide binding]; DNA binding site
1049565004508	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1049565004509	L,D-transpeptidase; Provisional; Region: PRK10260
1049565004510	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1049565004511	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
1049565004512	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
1049565004513	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
1049565004514	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1049565004515	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1049565004516	Walker A/P-loop; other site
1049565004517	ATP binding site [chemical binding]; other site
1049565004518	Q-loop/lid; other site
1049565004519	ABC transporter signature motif; other site
1049565004520	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1049565004521	Walker B; other site
1049565004522	D-loop; other site
1049565004523	ABC transporter; Region: ABC_tran_2; pfam12848
1049565004524	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1049565004525	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
1049565004526	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
1049565004527	Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599
1049565004528	putative active site [active]
1049565004529	putative catalytic site [active]
1049565004530	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565004531	D-galactonate transporter; Region: 2A0114; TIGR00893
1049565004532	putative substrate translocation pore; other site
1049565004533	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1049565004534	DNA binding site [nucleotide binding]
1049565004535	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1049565004536	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1049565004537	ligand binding site [chemical binding]; other site
1049565004538	dimerization interface [polypeptide binding]; other site
1049565004539	Protein of unknown function (DUF1479); Region: DUF1479; pfam07350
1049565004540	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
1049565004541	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1049565004542	active site
1049565004543	motif I; other site
1049565004544	motif II; other site
1049565004545	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1049565004546	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
1049565004547	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
1049565004548	dimer interface [polypeptide binding]; other site
1049565004549	active site
1049565004550	glycine loop; other site
1049565004551	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
1049565004552	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1049565004553	FeS/SAM binding site; other site
1049565004554	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
1049565004555	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1049565004556	ATP binding site [chemical binding]; other site
1049565004557	substrate interface [chemical binding]; other site
1049565004558	molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680
1049565004559	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1049565004560	dimer interface [polypeptide binding]; other site
1049565004561	putative functional site; other site
1049565004562	putative MPT binding site; other site
1049565004563	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
1049565004564	catalytic nucleophile [active]
1049565004565	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
1049565004566	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1049565004567	Walker A/P-loop; other site
1049565004568	ATP binding site [chemical binding]; other site
1049565004569	Q-loop/lid; other site
1049565004570	ABC transporter signature motif; other site
1049565004571	Walker B; other site
1049565004572	D-loop; other site
1049565004573	H-loop/switch region; other site
1049565004574	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1049565004575	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1049565004576	Walker A/P-loop; other site
1049565004577	ATP binding site [chemical binding]; other site
1049565004578	Q-loop/lid; other site
1049565004579	ABC transporter signature motif; other site
1049565004580	Walker B; other site
1049565004581	D-loop; other site
1049565004582	H-loop/switch region; other site
1049565004583	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1049565004584	glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413
1049565004585	The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499
1049565004586	glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081
1049565004587	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565004588	dimer interface [polypeptide binding]; other site
1049565004589	conserved gate region; other site
1049565004590	putative PBP binding loops; other site
1049565004591	ABC-ATPase subunit interface; other site
1049565004592	glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082
1049565004593	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1049565004594	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565004595	dimer interface [polypeptide binding]; other site
1049565004596	conserved gate region; other site
1049565004597	putative PBP binding loops; other site
1049565004598	ABC-ATPase subunit interface; other site
1049565004599	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
1049565004600	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1049565004601	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1049565004602	FeS/SAM binding site; other site
1049565004603	galactoside permease; Reviewed; Region: lacY; PRK09528
1049565004604	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565004605	putative substrate translocation pore; other site
1049565004606	biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302
1049565004607	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
1049565004608	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
1049565004609	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1049565004610	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
1049565004611	putative C-terminal domain interface [polypeptide binding]; other site
1049565004612	putative GSH binding site (G-site) [chemical binding]; other site
1049565004613	putative dimer interface [polypeptide binding]; other site
1049565004614	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
1049565004615	putative N-terminal domain interface [polypeptide binding]; other site
1049565004616	putative dimer interface [polypeptide binding]; other site
1049565004617	putative substrate binding pocket (H-site) [chemical binding]; other site
1049565004618	D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001
1049565004619	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1049565004620	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
1049565004621	DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681
1049565004622	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1049565004623	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1049565004624	PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385
1049565004625	active site
1049565004626	multidrug efflux system translocase MdfA; Provisional; Region: PRK15402
1049565004627	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565004628	putative substrate translocation pore; other site
1049565004629	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1049565004630	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1049565004631	active site
1049565004632	motif I; other site
1049565004633	motif II; other site
1049565004634	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1049565004635	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1049565004636	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565004637	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1049565004638	putative substrate translocation pore; other site
1049565004639	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
1049565004640	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1049565004641	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1049565004642	integrase; Provisional; Region: int; PHA02601
1049565004643	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1049565004644	active site
1049565004645	DNA binding site [nucleotide binding]
1049565004646	Int/Topo IB signature motif; other site
1049565004647	Uncharacterized conserved protein [Function unknown]; Region: COG4933
1049565004648	Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022
1049565004649	Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892
1049565004650	Protein of unknown function (DUF2724); Region: DUF2724; pfam10893
1049565004651	Protein of unknown function (DUF2732); Region: DUF2732; pfam10809
1049565004652	DksA-like zinc finger domain containing protein; Region: PHA00080
1049565004653	Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840
1049565004654	portal vertex protein; Provisional; Region: Q; PHA02536
1049565004655	Phage portal protein; Region: Phage_portal; pfam04860
1049565004656	terminase ATPase subunit; Provisional; Region: P; PHA02535
1049565004657	Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056
1049565004658	Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373
1049565004659	Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838
1049565004660	capsid protein; Provisional; Region: N; PHA02538
1049565004661	terminase endonuclease subunit; Provisional; Region: M; PHA02537
1049565004662	Phage small terminase subunit; Region: Phage_term_smal; pfam05944
1049565004663	Phage head completion protein (GPL); Region: Phage_GPL; pfam05926
1049565004664	P2-like prophage tail protein X [General function prediction only]; Region: COG5004
1049565004665	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
1049565004666	catalytic residues [active]
1049565004667	phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495
1049565004668	P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891
1049565004669	Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069
1049565004670	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
1049565004671	Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540
1049565004672	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
1049565004673	Baseplate J-like protein; Region: Baseplate_J; cl01294
1049565004674	Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385
1049565004675	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
1049565004676	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
1049565004677	major tail sheath protein; Provisional; Region: FI; PHA02560
1049565004678	Phage tail tube protein FII; Region: Phage_tube; cl01390
1049565004679	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
1049565004680	Phage P2 GpE; Region: Phage_P2_GpE; pfam06528
1049565004681	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
1049565004682	Phage protein U [General function prediction only]; Region: COG3499
1049565004683	tail protein; Provisional; Region: D; PHA02561
1049565004684	DNA-binding transcriptional regulator; Provisional; Region: PRK09678
1049565004685	Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606
1049565004686	putative transporter; Provisional; Region: PRK04972
1049565004687	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
1049565004688	TrkA-C domain; Region: TrkA_C; pfam02080
1049565004689	TrkA-C domain; Region: TrkA_C; pfam02080
1049565004690	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
1049565004691	Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045
1049565004692	Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066
1049565004693	GSH binding site [chemical binding]; other site
1049565004694	catalytic residues [active]
1049565004695	Protein of unknown function (DUF1418); Region: DUF1418; pfam07214
1049565004696	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
1049565004697	dimer interface [polypeptide binding]; other site
1049565004698	FMN binding site [chemical binding]; other site
1049565004699	NADPH bind site [chemical binding]; other site
1049565004700	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
1049565004701	RimK-like ATP-grasp domain; Region: RimK; pfam08443
1049565004702	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
1049565004703	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
1049565004704	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1049565004705	putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607
1049565004706	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1049565004707	Walker A/P-loop; other site
1049565004708	ATP binding site [chemical binding]; other site
1049565004709	Q-loop/lid; other site
1049565004710	ABC transporter signature motif; other site
1049565004711	Walker B; other site
1049565004712	D-loop; other site
1049565004713	H-loop/switch region; other site
1049565004714	TOBE domain; Region: TOBE_2; pfam08402
1049565004715	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1049565004716	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565004717	dimer interface [polypeptide binding]; other site
1049565004718	conserved gate region; other site
1049565004719	putative PBP binding loops; other site
1049565004720	ABC-ATPase subunit interface; other site
1049565004721	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1049565004722	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565004723	dimer interface [polypeptide binding]; other site
1049565004724	conserved gate region; other site
1049565004725	putative PBP binding loops; other site
1049565004726	ABC-ATPase subunit interface; other site
1049565004727	Protein of unknown function (DUF2593); Region: DUF2593; pfam10767
1049565004728	23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085
1049565004729	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1049565004730	S-adenosylmethionine binding site [chemical binding]; other site
1049565004731	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1049565004732	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1049565004733	active site
1049565004734	phosphorylation site [posttranslational modification]
1049565004735	intermolecular recognition site; other site
1049565004736	dimerization interface [polypeptide binding]; other site
1049565004737	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1049565004738	DNA binding site [nucleotide binding]
1049565004739	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
1049565004740	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1049565004741	dimer interface [polypeptide binding]; other site
1049565004742	phosphorylation site [posttranslational modification]
1049565004743	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1049565004744	ATP binding site [chemical binding]; other site
1049565004745	Mg2+ binding site [ion binding]; other site
1049565004746	G-X-G motif; other site
1049565004747	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
1049565004748	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1049565004749	substrate binding pocket [chemical binding]; other site
1049565004750	membrane-bound complex binding site; other site
1049565004751	hinge residues; other site
1049565004752	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1049565004753	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565004754	dimer interface [polypeptide binding]; other site
1049565004755	conserved gate region; other site
1049565004756	putative PBP binding loops; other site
1049565004757	ABC-ATPase subunit interface; other site
1049565004758	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1049565004759	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565004760	dimer interface [polypeptide binding]; other site
1049565004761	conserved gate region; other site
1049565004762	putative PBP binding loops; other site
1049565004763	ABC-ATPase subunit interface; other site
1049565004764	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
1049565004765	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1049565004766	substrate binding pocket [chemical binding]; other site
1049565004767	membrane-bound complex binding site; other site
1049565004768	hinge residues; other site
1049565004769	arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124
1049565004770	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1049565004771	Walker A/P-loop; other site
1049565004772	ATP binding site [chemical binding]; other site
1049565004773	Q-loop/lid; other site
1049565004774	ABC transporter signature motif; other site
1049565004775	Walker B; other site
1049565004776	D-loop; other site
1049565004777	H-loop/switch region; other site
1049565004778	putative lipoprotein; Provisional; Region: PRK10533
1049565004779	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1049565004780	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1049565004781	metal binding site [ion binding]; metal-binding site
1049565004782	active site
1049565004783	I-site; other site
1049565004784	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
1049565004785	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1049565004786	amidase catalytic site [active]
1049565004787	Zn binding residues [ion binding]; other site
1049565004788	substrate binding site [chemical binding]; other site
1049565004789	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1049565004790	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1049565004791	NAD(P) binding site [chemical binding]; other site
1049565004792	active site
1049565004793	atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245
1049565004794	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1049565004795	putative NAD(P) binding site [chemical binding]; other site
1049565004796	putative active site [active]
1049565004797	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
1049565004798	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
1049565004799	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
1049565004800	tetramer interface [polypeptide binding]; other site
1049565004801	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565004802	catalytic residue [active]
1049565004803	pyruvate dehydrogenase; Provisional; Region: PRK09124
1049565004804	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
1049565004805	PYR/PP interface [polypeptide binding]; other site
1049565004806	dimer interface [polypeptide binding]; other site
1049565004807	tetramer interface [polypeptide binding]; other site
1049565004808	TPP binding site [chemical binding]; other site
1049565004809	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1049565004810	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
1049565004811	TPP-binding site [chemical binding]; other site
1049565004812	DoxX; Region: DoxX; pfam07681
1049565004813	HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684
1049565004814	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
1049565004815	FAD binding pocket [chemical binding]; other site
1049565004816	FAD binding motif [chemical binding]; other site
1049565004817	phosphate binding motif [ion binding]; other site
1049565004818	beta-alpha-beta structure motif; other site
1049565004819	NAD binding pocket [chemical binding]; other site
1049565004820	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1049565004821	catalytic loop [active]
1049565004822	iron binding site [ion binding]; other site
1049565004823	hybrid cluster protein; Provisional; Region: PRK05290
1049565004824	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1049565004825	ACS interaction site; other site
1049565004826	CODH interaction site; other site
1049565004827	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
1049565004828	hybrid metal cluster; other site
1049565004829	Predicted membrane protein [Function unknown]; Region: COG2431
1049565004830	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
1049565004831	amphipathic channel; other site
1049565004832	Asn-Pro-Ala signature motifs; other site
1049565004833	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
1049565004834	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
1049565004835	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
1049565004836	putative active site [active]
1049565004837	putative metal-binding site [ion binding]; other site
1049565004838	macrolide transporter subunit MacA; Provisional; Region: PRK11578
1049565004839	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1049565004840	HlyD family secretion protein; Region: HlyD_3; pfam13437
1049565004841	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
1049565004842	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1049565004843	Walker A/P-loop; other site
1049565004844	ATP binding site [chemical binding]; other site
1049565004845	Q-loop/lid; other site
1049565004846	ABC transporter signature motif; other site
1049565004847	Walker B; other site
1049565004848	D-loop; other site
1049565004849	H-loop/switch region; other site
1049565004850	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1049565004851	FtsX-like permease family; Region: FtsX; pfam02687
1049565004852	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1049565004853	DNA-binding site [nucleotide binding]; DNA binding site
1049565004854	RNA-binding motif; other site
1049565004855	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
1049565004856	ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034
1049565004857	Clp amino terminal domain; Region: Clp_N; pfam02861
1049565004858	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1049565004859	Walker A motif; other site
1049565004860	ATP binding site [chemical binding]; other site
1049565004861	Walker B motif; other site
1049565004862	arginine finger; other site
1049565004863	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1049565004864	Walker A motif; other site
1049565004865	ATP binding site [chemical binding]; other site
1049565004866	Walker B motif; other site
1049565004867	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1049565004868	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1049565004869	rRNA binding site [nucleotide binding]; other site
1049565004870	predicted 30S ribosome binding site; other site
1049565004871	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
1049565004872	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160
1049565004873	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1049565004874	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1049565004875	Walker A/P-loop; other site
1049565004876	ATP binding site [chemical binding]; other site
1049565004877	Q-loop/lid; other site
1049565004878	ABC transporter signature motif; other site
1049565004879	Walker B; other site
1049565004880	D-loop; other site
1049565004881	H-loop/switch region; other site
1049565004882	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174
1049565004883	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1049565004884	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1049565004885	Walker A/P-loop; other site
1049565004886	ATP binding site [chemical binding]; other site
1049565004887	Q-loop/lid; other site
1049565004888	ABC transporter signature motif; other site
1049565004889	Walker B; other site
1049565004890	D-loop; other site
1049565004891	H-loop/switch region; other site
1049565004892	thioredoxin reductase; Provisional; Region: PRK10262
1049565004893	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1049565004894	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1049565004895	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
1049565004896	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1049565004897	putative DNA binding site [nucleotide binding]; other site
1049565004898	putative Zn2+ binding site [ion binding]; other site
1049565004899	AsnC family; Region: AsnC_trans_reg; pfam01037
1049565004900	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
1049565004901	DNA translocase FtsK; Provisional; Region: PRK10263
1049565004902	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1049565004903	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1049565004904	periplasmic chaperone LolA; Region: lolA; TIGR00547
1049565004905	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
1049565004906	recombination factor protein RarA; Reviewed; Region: PRK13342
1049565004907	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1049565004908	Walker A motif; other site
1049565004909	ATP binding site [chemical binding]; other site
1049565004910	Walker B motif; other site
1049565004911	arginine finger; other site
1049565004912	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1049565004913	seryl-tRNA synthetase; Provisional; Region: PRK05431
1049565004914	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1049565004915	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1049565004916	dimer interface [polypeptide binding]; other site
1049565004917	active site
1049565004918	motif 1; other site
1049565004919	motif 2; other site
1049565004920	motif 3; other site
1049565004921	anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990
1049565004922	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
1049565004923	putative [Fe4-S4] binding site [ion binding]; other site
1049565004924	putative molybdopterin cofactor binding site [chemical binding]; other site
1049565004925	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
1049565004926	putative molybdopterin cofactor binding site; other site
1049565004927	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
1049565004928	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
1049565004929	DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976
1049565004930	putative MFS family transporter protein; Provisional; Region: PRK03633
1049565004931	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565004932	putative substrate translocation pore; other site
1049565004933	pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145
1049565004934	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1049565004935	FeS/SAM binding site; other site
1049565004936	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
1049565004937	Pyruvate formate lyase 1; Region: PFL1; cd01678
1049565004938	coenzyme A binding site [chemical binding]; other site
1049565004939	active site
1049565004940	catalytic residues [active]
1049565004941	glycine loop; other site
1049565004942	formate transporter; Provisional; Region: PRK10805
1049565004943	uncharacterized domain; Region: TIGR00702
1049565004944	YcaO-like family; Region: YcaO; pfam02624
1049565004945	Predicted membrane protein [Function unknown]; Region: COG2323
1049565004946	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
1049565004947	homodimer interface [polypeptide binding]; other site
1049565004948	substrate-cofactor binding pocket; other site
1049565004949	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565004950	catalytic residue [active]
1049565004951	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
1049565004952	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1049565004953	hinge; other site
1049565004954	active site
1049565004955	cytidylate kinase; Provisional; Region: cmk; PRK00023
1049565004956	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1049565004957	CMP-binding site; other site
1049565004958	The sites determining sugar specificity; other site
1049565004959	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
1049565004960	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1049565004961	RNA binding site [nucleotide binding]; other site
1049565004962	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
1049565004963	RNA binding site [nucleotide binding]; other site
1049565004964	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
1049565004965	RNA binding site [nucleotide binding]; other site
1049565004966	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
1049565004967	RNA binding site [nucleotide binding]; other site
1049565004968	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
1049565004969	RNA binding site [nucleotide binding]; other site
1049565004970	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1049565004971	IHF dimer interface [polypeptide binding]; other site
1049565004972	IHF - DNA interface [nucleotide binding]; other site
1049565004973	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
1049565004974	ComEC family competence protein; Provisional; Region: PRK11539
1049565004975	Competence protein; Region: Competence; pfam03772
1049565004976	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1049565004977	lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176
1049565004978	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1049565004979	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1049565004980	Walker A/P-loop; other site
1049565004981	ATP binding site [chemical binding]; other site
1049565004982	Q-loop/lid; other site
1049565004983	ABC transporter signature motif; other site
1049565004984	Walker B; other site
1049565004985	D-loop; other site
1049565004986	H-loop/switch region; other site
1049565004987	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
1049565004988	tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682
1049565004989	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
1049565004990	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
1049565004991	Trm112p-like protein; Region: Trm112p; cl01066
1049565004992	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
1049565004993	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
1049565004994	Ligand binding site; other site
1049565004995	oligomer interface; other site
1049565004996	hypothetical protein; Provisional; Region: PRK10593
1049565004997	Phosphotransferase enzyme family; Region: APH; pfam01636
1049565004998	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1049565004999	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1049565005000	putative active site [active]
1049565005001	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1049565005002	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1049565005003	S-adenosylmethionine binding site [chemical binding]; other site
1049565005004	condesin subunit F; Provisional; Region: PRK05260
1049565005005	condesin subunit E; Provisional; Region: PRK05256
1049565005006	cell division protein MukB; Provisional; Region: mukB; PRK04863
1049565005007	P-loop containing region of AAA domain; Region: AAA_29; cl17516
1049565005008	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
1049565005009	murein L,D-transpeptidase; Provisional; Region: PRK10594
1049565005010	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1049565005011	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1049565005012	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1049565005013	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
1049565005014	Peptidase M15; Region: Peptidase_M15_3; cl01194
1049565005015	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1049565005016	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
1049565005017	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1049565005018	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565005019	homodimer interface [polypeptide binding]; other site
1049565005020	catalytic residue [active]
1049565005021	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1049565005022	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1049565005023	eyelet of channel; other site
1049565005024	trimer interface [polypeptide binding]; other site
1049565005025	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
1049565005026	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
1049565005027	putative dimer interface [polypeptide binding]; other site
1049565005028	putative anticodon binding site; other site
1049565005029	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
1049565005030	homodimer interface [polypeptide binding]; other site
1049565005031	motif 1; other site
1049565005032	motif 2; other site
1049565005033	active site
1049565005034	motif 3; other site
1049565005035	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1049565005036	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1049565005037	dimerization interface [polypeptide binding]; other site
1049565005038	putative DNA binding site [nucleotide binding]; other site
1049565005039	putative Zn2+ binding site [ion binding]; other site
1049565005040	AsnC family; Region: AsnC_trans_reg; pfam01037
1049565005041	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
1049565005042	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640
1049565005043	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1049565005044	catalytic residue [active]
1049565005045	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
1049565005046	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
1049565005047	allantoate amidohydrolase; Reviewed; Region: PRK12893
1049565005048	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
1049565005049	active site
1049565005050	metal binding site [ion binding]; metal-binding site
1049565005051	dimer interface [polypeptide binding]; other site
1049565005052	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1049565005053	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
1049565005054	metal binding site [ion binding]; metal-binding site
1049565005055	putative dimer interface [polypeptide binding]; other site
1049565005056	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
1049565005057	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
1049565005058	active site
1049565005059	aminopeptidase N; Provisional; Region: pepN; PRK14015
1049565005060	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
1049565005061	active site
1049565005062	Zn binding site [ion binding]; other site
1049565005063	aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247
1049565005064	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1049565005065	Walker A/P-loop; other site
1049565005066	ATP binding site [chemical binding]; other site
1049565005067	Q-loop/lid; other site
1049565005068	ABC transporter signature motif; other site
1049565005069	Walker B; other site
1049565005070	D-loop; other site
1049565005071	H-loop/switch region; other site
1049565005072	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1049565005073	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565005074	dimer interface [polypeptide binding]; other site
1049565005075	conserved gate region; other site
1049565005076	putative PBP binding loops; other site
1049565005077	ABC-ATPase subunit interface; other site
1049565005078	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
1049565005079	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
1049565005080	active site
1049565005081	dimer interface [polypeptide binding]; other site
1049565005082	non-prolyl cis peptide bond; other site
1049565005083	insertion regions; other site
1049565005084	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1049565005085	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1049565005086	substrate binding pocket [chemical binding]; other site
1049565005087	membrane-bound complex binding site; other site
1049565005088	hinge residues; other site
1049565005089	NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569
1049565005090	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1049565005091	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
1049565005092	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
1049565005093	quinone interaction residues [chemical binding]; other site
1049565005094	active site
1049565005095	catalytic residues [active]
1049565005096	FMN binding site [chemical binding]; other site
1049565005097	substrate binding site [chemical binding]; other site
1049565005098	Protein of unknown function (DUF1379); Region: DUF1379; pfam07126
1049565005099	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
1049565005100	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
1049565005101	MOSC domain; Region: MOSC; pfam03473
1049565005102	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1049565005103	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1049565005104	catalytic loop [active]
1049565005105	iron binding site [ion binding]; other site
1049565005106	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
1049565005107	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
1049565005108	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1049565005109	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1049565005110	S-adenosylmethionine binding site [chemical binding]; other site
1049565005111	ABC transporter ATPase component; Reviewed; Region: PRK11147
1049565005112	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1049565005113	Walker A/P-loop; other site
1049565005114	ATP binding site [chemical binding]; other site
1049565005115	Q-loop/lid; other site
1049565005116	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1049565005117	ABC transporter; Region: ABC_tran_2; pfam12848
1049565005118	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1049565005119	paraquat-inducible membrane protein A; Provisional; Region: PRK15103
1049565005120	Paraquat-inducible protein A; Region: PqiA; pfam04403
1049565005121	Paraquat-inducible protein A; Region: PqiA; pfam04403
1049565005122	paraquat-inducible protein B; Provisional; Region: PRK10807
1049565005123	mce related protein; Region: MCE; pfam02470
1049565005124	mce related protein; Region: MCE; pfam02470
1049565005125	mce related protein; Region: MCE; pfam02470
1049565005126	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
1049565005127	Protein of unknown function (DUF330); Region: DUF330; pfam03886
1049565005128	ribosome modulation factor; Provisional; Region: PRK14563
1049565005129	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
1049565005130	active site 1 [active]
1049565005131	dimer interface [polypeptide binding]; other site
1049565005132	active site 2 [active]
1049565005133	Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067
1049565005134	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1049565005135	Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097
1049565005136	outer membrane protein A; Reviewed; Region: PRK10808
1049565005137	OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389
1049565005138	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1049565005139	ligand binding site [chemical binding]; other site
1049565005140	SOS cell division inhibitor; Provisional; Region: PRK10595
1049565005141	TfoX N-terminal domain; Region: TfoX_N; pfam04993
1049565005142	TfoX C-terminal domain; Region: TfoX_C; pfam04994
1049565005143	TIGR01666 family membrane protein; Region: YCCS
1049565005144	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
1049565005145	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1049565005146	Predicted membrane protein [Function unknown]; Region: COG3304
1049565005147	Domain of unknown function (DUF307); Region: DUF307; pfam03733
1049565005148	Domain of unknown function (DUF307); Region: DUF307; pfam03733
1049565005149	DNA helicase IV; Provisional; Region: helD; PRK11054
1049565005150	DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462
1049565005151	Part of AAA domain; Region: AAA_19; pfam13245
1049565005152	Family description; Region: UvrD_C_2; pfam13538
1049565005153	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
1049565005154	active site
1049565005155	dimer interfaces [polypeptide binding]; other site
1049565005156	catalytic residues [active]
1049565005157	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
1049565005158	heat shock protein HspQ; Provisional; Region: PRK14129
1049565005159	23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128
1049565005160	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
1049565005161	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
1049565005162	putative RNA binding site [nucleotide binding]; other site
1049565005163	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1049565005164	S-adenosylmethionine binding site [chemical binding]; other site
1049565005165	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1049565005166	substrate binding site [chemical binding]; other site
1049565005167	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1049565005168	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565005169	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1049565005170	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1049565005171	rod shape-determining protein MreC; Provisional; Region: PRK13922
1049565005172	Family description; Region: UvrD_C_2; pfam13538
1049565005173	acylphosphatase; Provisional; Region: PRK14426
1049565005174	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
1049565005175	sulfur transfer protein TusE; Provisional; Region: PRK11508
1049565005176	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
1049565005177	YccA-like proteins; Region: YccA_like; cd10433
1049565005178	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
1049565005179	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1049565005180	peptide binding site [polypeptide binding]; other site
1049565005181	potential frameshift: common BLAST hit: gi|152969566|ref|YP_001334675.1| putative protease
1049565005182	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1049565005183	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
1049565005184	FMN-binding pocket [chemical binding]; other site
1049565005185	flavin binding motif; other site
1049565005186	phosphate binding motif [ion binding]; other site
1049565005187	beta-alpha-beta structure motif; other site
1049565005188	NAD binding pocket [chemical binding]; other site
1049565005189	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1049565005190	catalytic loop [active]
1049565005191	iron binding site [ion binding]; other site
1049565005192	succinic semialdehyde dehydrogenase; Region: PLN02278
1049565005193	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1049565005194	tetramerization interface [polypeptide binding]; other site
1049565005195	NAD(P) binding site [chemical binding]; other site
1049565005196	catalytic residues [active]
1049565005197	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1049565005198	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
1049565005199	[2Fe-2S] cluster binding site [ion binding]; other site
1049565005200	C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886
1049565005201	putative alpha subunit interface [polypeptide binding]; other site
1049565005202	putative active site [active]
1049565005203	putative substrate binding site [chemical binding]; other site
1049565005204	Fe binding site [ion binding]; other site
1049565005205	putative transporter; Provisional; Region: PRK09950
1049565005206	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
1049565005207	tartrate dehydrogenase; Region: TTC; TIGR02089
1049565005208	transcriptional activator TtdR; Provisional; Region: PRK09801
1049565005209	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565005210	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
1049565005211	putative effector binding pocket; other site
1049565005212	putative dimerization interface [polypeptide binding]; other site
1049565005213	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1049565005214	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1049565005215	gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847
1049565005216	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
1049565005217	NAD(P) binding site [chemical binding]; other site
1049565005218	catalytic residues [active]
1049565005219	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
1049565005220	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1049565005221	non-specific DNA binding site [nucleotide binding]; other site
1049565005222	salt bridge; other site
1049565005223	sequence-specific DNA binding site [nucleotide binding]; other site
1049565005224	Cupin domain; Region: Cupin_2; pfam07883
1049565005225	gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366
1049565005226	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
1049565005227	catalytic triad [active]
1049565005228	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1049565005229	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1049565005230	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1049565005231	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1049565005232	classical (c) SDRs; Region: SDR_c; cd05233
1049565005233	NAD(P) binding site [chemical binding]; other site
1049565005234	active site
1049565005235	Predicted transcriptional regulators [Transcription]; Region: COG1733
1049565005236	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1049565005237	glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173
1049565005238	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
1049565005239	catalytic core [active]
1049565005240	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
1049565005241	hypothetical protein; Provisional; Region: PRK10174
1049565005242	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
1049565005243	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1049565005244	General stress protein [General function prediction only]; Region: GsiB; COG3729
1049565005245	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1049565005246	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
1049565005247	pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615
1049565005248	Nitroreductase-like family 5.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148
1049565005249	putative FMN binding site [chemical binding]; other site
1049565005250	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
1049565005251	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1049565005252	homotrimer interaction site [polypeptide binding]; other site
1049565005253	putative active site [active]
1049565005254	Isochorismatase family; Region: Isochorismatase; pfam00857
1049565005255	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1049565005256	catalytic triad [active]
1049565005257	conserved cis-peptide bond; other site
1049565005258	pyrimidine utilization protein A; Region: RutA; TIGR03612
1049565005259	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
1049565005260	active site
1049565005261	dimer interface [polypeptide binding]; other site
1049565005262	non-prolyl cis peptide bond; other site
1049565005263	insertion regions; other site
1049565005264	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1049565005265	HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008
1049565005266	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1049565005267	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
1049565005268	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755
1049565005269	trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809
1049565005270	Predicted transcriptional regulator [Transcription]; Region: COG3905
1049565005271	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
1049565005272	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
1049565005273	Glutamate binding site [chemical binding]; other site
1049565005274	NAD binding site [chemical binding]; other site
1049565005275	catalytic residues [active]
1049565005276	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1049565005277	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
1049565005278	Na binding site [ion binding]; other site
1049565005279	Protein of unknown function (DUF3574); Region: DUF3574; pfam12098
1049565005280	Nucleoside recognition; Region: Gate; pfam07670
1049565005281	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1049565005282	FTR1 family protein; Region: TIGR00145
1049565005283	inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378
1049565005284	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
1049565005285	Imelysin; Region: Peptidase_M75; pfam09375
1049565005286	Tat-translocated enzyme; Region: tat_substr_1; TIGR01412
1049565005287	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
1049565005288	hypothetical protein; Provisional; Region: PRK10536
1049565005289	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1049565005290	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
1049565005291	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1049565005292	catalytic residues [active]
1049565005293	hinge region; other site
1049565005294	alpha helical domain; other site
1049565005295	Isochorismatase family; Region: Isochorismatase; pfam00857
1049565005296	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
1049565005297	catalytic triad [active]
1049565005298	dimer interface [polypeptide binding]; other site
1049565005299	conserved cis-peptide bond; other site
1049565005300	Pirin-related protein [General function prediction only]; Region: COG1741
1049565005301	Pirin; Region: Pirin; pfam02678
1049565005302	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
1049565005303	LysR family transcriptional regulator; Provisional; Region: PRK14997
1049565005304	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565005305	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
1049565005306	putative effector binding pocket; other site
1049565005307	putative dimerization interface [polypeptide binding]; other site
1049565005308	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1049565005309	Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999
1049565005310	active site
1049565005311	Mn binding site [ion binding]; other site
1049565005312	bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469
1049565005313	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
1049565005314	putative ligand binding site [chemical binding]; other site
1049565005315	NAD binding site [chemical binding]; other site
1049565005316	dimerization interface [polypeptide binding]; other site
1049565005317	catalytic site [active]
1049565005318	putative hydrolase; Validated; Region: PRK09248
1049565005319	Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437
1049565005320	active site
1049565005321	Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381
1049565005322	Protein of unknown function (DUF1097); Region: DUF1097; pfam06496
1049565005323	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
1049565005324	putative ADP-ribose binding site [chemical binding]; other site
1049565005325	putative active site [active]
1049565005326	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
1049565005327	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1049565005328	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
1049565005329	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1049565005330	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
1049565005331	Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433
1049565005332	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1049565005333	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
1049565005334	Ligand binding site; other site
1049565005335	DXD motif; other site
1049565005336	lipoprotein; Provisional; Region: PRK10175
1049565005337	secY/secA suppressor protein; Provisional; Region: PRK11467
1049565005338	drug efflux system protein MdtG; Provisional; Region: PRK09874
1049565005339	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565005340	putative substrate translocation pore; other site
1049565005341	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
1049565005342	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1049565005343	putative acyl-acceptor binding pocket; other site
1049565005344	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
1049565005345	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
1049565005346	active site residue [active]
1049565005347	N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259
1049565005348	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1049565005349	biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301
1049565005350	DNA damage-inducible protein I; Provisional; Region: PRK10597
1049565005351	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
1049565005352	active site
1049565005353	substrate binding pocket [chemical binding]; other site
1049565005354	dimer interface [polypeptide binding]; other site
1049565005355	lipoprotein; Provisional; Region: PRK10598
1049565005356	multidrug resistance protein MdtH; Provisional; Region: PRK11646
1049565005357	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565005358	putative substrate translocation pore; other site
1049565005359	ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809
1049565005360	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1049565005361	hypothetical protein; Provisional; Region: PRK11239
1049565005362	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132
1049565005363	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1049565005364	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1049565005365	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
1049565005366	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
1049565005367	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1049565005368	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565005369	putative substrate translocation pore; other site
1049565005370	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565005371	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565005372	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1049565005373	putative effector binding pocket; other site
1049565005374	dimerization interface [polypeptide binding]; other site
1049565005375	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
1049565005376	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
1049565005377	homodimer interface [polypeptide binding]; other site
1049565005378	oligonucleotide binding site [chemical binding]; other site
1049565005379	Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111
1049565005380	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
1049565005381	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1049565005382	RNA binding surface [nucleotide binding]; other site
1049565005383	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1049565005384	active site
1049565005385	Maf-like protein; Region: Maf; pfam02545
1049565005386	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1049565005387	active site
1049565005388	dimer interface [polypeptide binding]; other site
1049565005389	hypothetical protein; Provisional; Region: PRK11193
1049565005390	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
1049565005391	putative phosphate acyltransferase; Provisional; Region: PRK05331
1049565005392	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
1049565005393	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1049565005394	dimer interface [polypeptide binding]; other site
1049565005395	active site
1049565005396	CoA binding pocket [chemical binding]; other site
1049565005397	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1049565005398	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1049565005399	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1049565005400	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1049565005401	NAD(P) binding site [chemical binding]; other site
1049565005402	homotetramer interface [polypeptide binding]; other site
1049565005403	homodimer interface [polypeptide binding]; other site
1049565005404	active site
1049565005405	acyl carrier protein; Provisional; Region: acpP; PRK00982
1049565005406	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
1049565005407	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1049565005408	dimer interface [polypeptide binding]; other site
1049565005409	active site
1049565005410	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1049565005411	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
1049565005412	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565005413	catalytic residue [active]
1049565005414	conserved hypothetical protein, YceG family; Region: TIGR00247
1049565005415	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
1049565005416	dimerization interface [polypeptide binding]; other site
1049565005417	thymidylate kinase; Validated; Region: tmk; PRK00698
1049565005418	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1049565005419	TMP-binding site; other site
1049565005420	ATP-binding site [chemical binding]; other site
1049565005421	DNA polymerase III subunit delta'; Validated; Region: PRK07993
1049565005422	DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115
1049565005423	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1049565005424	active site
1049565005425	PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089
1049565005426	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1049565005427	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1049565005428	active site turn [active]
1049565005429	phosphorylation site [posttranslational modification]
1049565005430	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
1049565005431	nucleotide binding site/active site [active]
1049565005432	HIT family signature motif; other site
1049565005433	catalytic residue [active]
1049565005434	Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633
1049565005435	Putative periplasmic lipoprotein; Region: DUF1425; cd09030
1049565005436	putative dimer interface [polypeptide binding]; other site
1049565005437	Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417
1049565005438	thiamine kinase; Region: ycfN_thiK; TIGR02721
1049565005439	active site
1049565005440	ATP binding site [chemical binding]; other site
1049565005441	thiamine kinase; Provisional; Region: thiK; PRK10271
1049565005442	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1049565005443	beta-hexosaminidase; Provisional; Region: PRK05337
1049565005444	hypothetical protein; Provisional; Region: PRK04940
1049565005445	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1049565005446	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1049565005447	hypothetical protein; Provisional; Region: PRK11280
1049565005448	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1049565005449	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1049565005450	N-terminal plug; other site
1049565005451	ligand-binding site [chemical binding]; other site
1049565005452	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1049565005453	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1049565005454	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
1049565005455	L,D-transpeptidase; Provisional; Region: PRK10190
1049565005456	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1049565005457	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1049565005458	transcription-repair coupling factor; Provisional; Region: PRK10689
1049565005459	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
1049565005460	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1049565005461	ATP binding site [chemical binding]; other site
1049565005462	putative Mg++ binding site [ion binding]; other site
1049565005463	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1049565005464	nucleotide binding region [chemical binding]; other site
1049565005465	ATP-binding site [chemical binding]; other site
1049565005466	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
1049565005467	outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814
1049565005468	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1049565005469	FtsX-like permease family; Region: FtsX; pfam02687
1049565005470	lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629
1049565005471	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1049565005472	Walker A/P-loop; other site
1049565005473	ATP binding site [chemical binding]; other site
1049565005474	Q-loop/lid; other site
1049565005475	ABC transporter signature motif; other site
1049565005476	Walker B; other site
1049565005477	D-loop; other site
1049565005478	H-loop/switch region; other site
1049565005479	outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146
1049565005480	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1049565005481	FtsX-like permease family; Region: FtsX; pfam02687
1049565005482	fructokinase; Reviewed; Region: PRK09557
1049565005483	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1049565005484	nucleotide binding site [chemical binding]; other site
1049565005485	NAD-dependent deacetylase; Provisional; Region: PRK00481
1049565005486	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
1049565005487	NAD+ binding site [chemical binding]; other site
1049565005488	substrate binding site [chemical binding]; other site
1049565005489	Zn binding site [ion binding]; other site
1049565005490	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1049565005491	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1049565005492	DNA binding residues [nucleotide binding]
1049565005493	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1049565005494	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1049565005495	substrate binding site [chemical binding]; other site
1049565005496	dimer interface [polypeptide binding]; other site
1049565005497	triosephosphate isomerase; Provisional; Region: PRK14565
1049565005498	catalytic triad [active]
1049565005499	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
1049565005500	Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873
1049565005501	Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612
1049565005502	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
1049565005503	2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274
1049565005504	PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829
1049565005505	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
1049565005506	transaldolase-like protein; Provisional; Region: PTZ00411
1049565005507	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
1049565005508	active site
1049565005509	dimer interface [polypeptide binding]; other site
1049565005510	catalytic residue [active]
1049565005511	transketolase; Reviewed; Region: PRK12753
1049565005512	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1049565005513	TPP-binding site [chemical binding]; other site
1049565005514	dimer interface [polypeptide binding]; other site
1049565005515	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1049565005516	PYR/PP interface [polypeptide binding]; other site
1049565005517	dimer interface [polypeptide binding]; other site
1049565005518	TPP binding site [chemical binding]; other site
1049565005519	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1049565005520	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008
1049565005521	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
1049565005522	dimer interface [polypeptide binding]; other site
1049565005523	acyl-activating enzyme (AAE) consensus motif; other site
1049565005524	putative active site [active]
1049565005525	AMP binding site [chemical binding]; other site
1049565005526	putative CoA binding site [chemical binding]; other site
1049565005527	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
1049565005528	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1049565005529	NAD(P) binding site [chemical binding]; other site
1049565005530	catalytic residues [active]
1049565005531	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
1049565005532	spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501
1049565005533	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
1049565005534	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1049565005535	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565005536	dimer interface [polypeptide binding]; other site
1049565005537	conserved gate region; other site
1049565005538	putative PBP binding loops; other site
1049565005539	ABC-ATPase subunit interface; other site
1049565005540	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1049565005541	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565005542	dimer interface [polypeptide binding]; other site
1049565005543	conserved gate region; other site
1049565005544	putative PBP binding loops; other site
1049565005545	ABC-ATPase subunit interface; other site
1049565005546	putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452
1049565005547	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
1049565005548	Walker A/P-loop; other site
1049565005549	ATP binding site [chemical binding]; other site
1049565005550	Q-loop/lid; other site
1049565005551	ABC transporter signature motif; other site
1049565005552	Walker B; other site
1049565005553	D-loop; other site
1049565005554	H-loop/switch region; other site
1049565005555	TOBE domain; Region: TOBE_2; pfam08402
1049565005556	Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195
1049565005557	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
1049565005558	metal binding site [ion binding]; metal-binding site
1049565005559	dimer interface [polypeptide binding]; other site
1049565005560	Uncharacterized conserved protein [Function unknown]; Region: COG2850
1049565005561	sensor protein PhoQ; Provisional; Region: PRK10815
1049565005562	PhoQ Sensor; Region: PhoQ_Sensor; pfam08918
1049565005563	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
1049565005564	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1049565005565	ATP binding site [chemical binding]; other site
1049565005566	Mg2+ binding site [ion binding]; other site
1049565005567	G-X-G motif; other site
1049565005568	DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816
1049565005569	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1049565005570	active site
1049565005571	phosphorylation site [posttranslational modification]
1049565005572	intermolecular recognition site; other site
1049565005573	dimerization interface [polypeptide binding]; other site
1049565005574	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1049565005575	DNA binding site [nucleotide binding]
1049565005576	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1049565005577	Helix-turn-helix domain; Region: HTH_18; pfam12833
1049565005578	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565005579	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
1049565005580	adenylosuccinate lyase; Provisional; Region: PRK09285
1049565005581	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
1049565005582	tetramer interface [polypeptide binding]; other site
1049565005583	active site
1049565005584	putative lysogenization regulator; Reviewed; Region: PRK00218
1049565005585	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1049565005586	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420
1049565005587	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
1049565005588	nudix motif; other site
1049565005589	23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394
1049565005590	Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566
1049565005591	probable active site [active]
1049565005592	isocitrate dehydrogenase; Validated; Region: PRK07362
1049565005593	isocitrate dehydrogenase; Reviewed; Region: PRK07006
1049565005594	potential frameshift: common BLAST hit: gi|375260349|ref|YP_005019519.1| gp24
1049565005595	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
1049565005596	Domain of unknown function (DUF1983); Region: DUF1983; pfam09327
1049565005597	Fibronectin type III protein; Region: DUF3672; pfam12421
1049565005598	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
1049565005599	MASE2 domain; Region: MASE2; pfam05230
1049565005600	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1049565005601	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1049565005602	metal binding site [ion binding]; metal-binding site
1049565005603	active site
1049565005604	I-site; other site
1049565005605	EAL domain; Region: EAL; pfam00563
1049565005606	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
1049565005607	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1049565005608	dimerization interface [polypeptide binding]; other site
1049565005609	putative DNA binding site [nucleotide binding]; other site
1049565005610	putative Zn2+ binding site [ion binding]; other site
1049565005611	ACT domain-containing protein [General function prediction only]; Region: COG4747
1049565005612	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1049565005613	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
1049565005614	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813
1049565005615	Protein of unknown function (DUF1272); Region: DUF1272; pfam06906
1049565005616	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
1049565005617	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1049565005618	NAD binding site [chemical binding]; other site
1049565005619	catalytic Zn binding site [ion binding]; other site
1049565005620	structural Zn binding site [ion binding]; other site
1049565005621	General stress protein [General function prediction only]; Region: GsiB; COG3729
1049565005622	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
1049565005623	dimerization interface [polypeptide binding]; other site
1049565005624	metal binding site [ion binding]; metal-binding site
1049565005625	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
1049565005626	dinuclear metal binding motif [ion binding]; other site
1049565005627	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
1049565005628	dimanganese center [ion binding]; other site
1049565005629	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1049565005630	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1049565005631	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1049565005632	Helix-turn-helix domain; Region: HTH_39; pfam14090
1049565005633	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1049565005634	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977
1049565005635	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
1049565005636	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565005637	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
1049565005638	dimerization interface [polypeptide binding]; other site
1049565005639	substrate binding pocket [chemical binding]; other site
1049565005640	potential frameshift: common BLAST hit: gi|152969717|ref|YP_001334826.1| putative sensor kinase
1049565005641	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1049565005642	Zn2+ binding site [ion binding]; other site
1049565005643	Mg2+ binding site [ion binding]; other site
1049565005644	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1049565005645	Zn2+ binding site [ion binding]; other site
1049565005646	Mg2+ binding site [ion binding]; other site
1049565005647	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
1049565005648	active site
1049565005649	homotetramer interface [polypeptide binding]; other site
1049565005650	homodimer interface [polypeptide binding]; other site
1049565005651	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
1049565005652	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1049565005653	putative acyl-acceptor binding pocket; other site
1049565005654	leucine export protein LeuE; Provisional; Region: PRK10958
1049565005655	Protein of unknown function (DUF2534); Region: DUF2534; pfam10749
1049565005656	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1049565005657	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1049565005658	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1049565005659	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1049565005660	metal binding site [ion binding]; metal-binding site
1049565005661	active site
1049565005662	I-site; other site
1049565005663	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
1049565005664	Domain of unknown function (DUF333); Region: DUF333; pfam03891
1049565005665	Uncharacterized conserved protein [Function unknown]; Region: COG3189
1049565005666	Uncharacterized conserved protein [Function unknown]; Region: COG1683
1049565005667	hypothetical protein; Validated; Region: PRK06186
1049565005668	conserved cys residue [active]
1049565005669	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
1049565005670	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565005671	putative substrate translocation pore; other site
1049565005672	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1049565005673	Predicted membrane protein [Function unknown]; Region: COG2707
1049565005674	YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function.  The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336
1049565005675	putative deacylase active site [active]
1049565005676	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1049565005677	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1049565005678	DinI-like family; Region: DinI; cl11630
1049565005679	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
1049565005680	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1049565005681	Catalytic site [active]
1049565005682	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
1049565005683	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
1049565005684	active site
1049565005685	DNA binding site [nucleotide binding]
1049565005686	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
1049565005687	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565005688	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565005689	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
1049565005690	putative effector binding pocket; other site
1049565005691	putative dimerization interface [polypeptide binding]; other site
1049565005692	short chain dehydrogenase; Provisional; Region: PRK06500
1049565005693	classical (c) SDRs; Region: SDR_c; cd05233
1049565005694	NAD(P) binding site [chemical binding]; other site
1049565005695	active site
1049565005696	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1049565005697	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565005698	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565005699	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565005700	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1049565005701	dimerization interface [polypeptide binding]; other site
1049565005702	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1049565005703	catalytic residues [active]
1049565005704	dimer interface [polypeptide binding]; other site
1049565005705	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14470
1049565005706	hypothetical protein; Provisional; Region: PRK05325
1049565005707	PrkA family serine protein kinase; Provisional; Region: PRK15455
1049565005708	AAA ATPase domain; Region: AAA_16; pfam13191
1049565005709	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1049565005710	Walker A motif; other site
1049565005711	ATP binding site [chemical binding]; other site
1049565005712	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
1049565005713	Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713
1049565005714	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1049565005715	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1049565005716	active site
1049565005717	catalytic tetrad [active]
1049565005718	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
1049565005719	active site
1049565005720	phosphate binding residues; other site
1049565005721	catalytic residues [active]
1049565005722	glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425
1049565005723	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1049565005724	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1049565005725	methionine sulfoxide reductase B; Provisional; Region: PRK00222
1049565005726	SelR domain; Region: SelR; pfam01641
1049565005727	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139
1049565005728	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1049565005729	active site
1049565005730	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
1049565005731	Glyco_18 domain; Region: Glyco_18; smart00636
1049565005732	active site
1049565005733	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
1049565005734	Isochorismatase family; Region: Isochorismatase; pfam00857
1049565005735	catalytic triad [active]
1049565005736	metal binding site [ion binding]; metal-binding site
1049565005737	conserved cis-peptide bond; other site
1049565005738	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
1049565005739	active site
1049565005740	homodimer interface [polypeptide binding]; other site
1049565005741	protease 4; Provisional; Region: PRK10949
1049565005742	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
1049565005743	tandem repeat interface [polypeptide binding]; other site
1049565005744	oligomer interface [polypeptide binding]; other site
1049565005745	active site residues [active]
1049565005746	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019
1049565005747	tandem repeat interface [polypeptide binding]; other site
1049565005748	oligomer interface [polypeptide binding]; other site
1049565005749	active site residues [active]
1049565005750	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
1049565005751	putative FMN binding site [chemical binding]; other site
1049565005752	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
1049565005753	active site
1049565005754	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1049565005755	selenophosphate synthetase; Provisional; Region: PRK00943
1049565005756	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
1049565005757	dimerization interface [polypeptide binding]; other site
1049565005758	putative ATP binding site [chemical binding]; other site
1049565005759	DNA topoisomerase III; Provisional; Region: PRK07726
1049565005760	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
1049565005761	active site
1049565005762	putative interdomain interaction site [polypeptide binding]; other site
1049565005763	putative metal-binding site [ion binding]; other site
1049565005764	putative nucleotide binding site [chemical binding]; other site
1049565005765	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1049565005766	domain I; other site
1049565005767	DNA binding groove [nucleotide binding]
1049565005768	phosphate binding site [ion binding]; other site
1049565005769	domain II; other site
1049565005770	domain III; other site
1049565005771	nucleotide binding site [chemical binding]; other site
1049565005772	catalytic site [active]
1049565005773	domain IV; other site
1049565005774	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
1049565005775	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
1049565005776	NAD(P) binding site [chemical binding]; other site
1049565005777	glutamate dehydrogenase; Provisional; Region: PRK09414
1049565005778	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1049565005779	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
1049565005780	NAD(P) binding site [chemical binding]; other site
1049565005781	potential frameshift: common BLAST hit: gi|152969765|ref|YP_001334874.1| pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase
1049565005782	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
1049565005783	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
1049565005784	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
1049565005785	active site residue [active]
1049565005786	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1049565005787	active site residue [active]
1049565005788	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136
1049565005789	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1049565005790	Walker A/P-loop; other site
1049565005791	ATP binding site [chemical binding]; other site
1049565005792	Q-loop/lid; other site
1049565005793	ABC transporter signature motif; other site
1049565005794	Walker B; other site
1049565005795	D-loop; other site
1049565005796	H-loop/switch region; other site
1049565005797	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565005798	ABC-ATPase subunit interface; other site
1049565005799	putative PBP binding loops; other site
1049565005800	hypothetical protein; Provisional; Region: PRK11622
1049565005801	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134
1049565005802	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1049565005803	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1049565005804	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1049565005805	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1049565005806	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1049565005807	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1049565005808	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
1049565005809	putative catalytic site [active]
1049565005810	putative phosphate binding site [ion binding]; other site
1049565005811	active site
1049565005812	metal binding site A [ion binding]; metal-binding site
1049565005813	DNA binding site [nucleotide binding]
1049565005814	putative AP binding site [nucleotide binding]; other site
1049565005815	putative metal binding site B [ion binding]; other site
1049565005816	bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381
1049565005817	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1049565005818	inhibitor-cofactor binding pocket; inhibition site
1049565005819	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565005820	catalytic residue [active]
1049565005821	arginine succinyltransferase; Provisional; Region: PRK10456
1049565005822	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
1049565005823	succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457
1049565005824	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
1049565005825	NAD(P) binding site [chemical binding]; other site
1049565005826	catalytic residues [active]
1049565005827	succinylarginine dihydrolase; Provisional; Region: PRK13281
1049565005828	Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855
1049565005829	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
1049565005830	putative active site [active]
1049565005831	Zn binding site [ion binding]; other site
1049565005832	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
1049565005833	dimer interface [polypeptide binding]; other site
1049565005834	nucleotide excision repair endonuclease; Provisional; Region: PRK10545
1049565005835	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1049565005836	GIY-YIG motif/motif A; other site
1049565005837	active site
1049565005838	catalytic site [active]
1049565005839	putative DNA binding site [nucleotide binding]; other site
1049565005840	metal binding site [ion binding]; metal-binding site
1049565005841	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
1049565005842	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1049565005843	homodimer interface [polypeptide binding]; other site
1049565005844	NAD binding pocket [chemical binding]; other site
1049565005845	ATP binding pocket [chemical binding]; other site
1049565005846	Mg binding site [ion binding]; other site
1049565005847	active-site loop [active]
1049565005848	DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251
1049565005849	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
1049565005850	active site
1049565005851	P-loop; other site
1049565005852	phosphorylation site [posttranslational modification]
1049565005853	PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297
1049565005854	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1049565005855	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
1049565005856	methionine cluster; other site
1049565005857	active site
1049565005858	phosphorylation site [posttranslational modification]
1049565005859	metal binding site [ion binding]; metal-binding site
1049565005860	DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296
1049565005861	Cupin domain; Region: Cupin_2; pfam07883
1049565005862	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565005863	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
1049565005864	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
1049565005865	NAD binding site [chemical binding]; other site
1049565005866	sugar binding site [chemical binding]; other site
1049565005867	divalent metal binding site [ion binding]; other site
1049565005868	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1049565005869	dimer interface [polypeptide binding]; other site
1049565005870	Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803
1049565005871	putative active site [active]
1049565005872	YdjC motif; other site
1049565005873	Mg binding site [ion binding]; other site
1049565005874	putative homodimer interface [polypeptide binding]; other site
1049565005875	hydroperoxidase II; Provisional; Region: katE; PRK11249
1049565005876	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
1049565005877	tetramer interface [polypeptide binding]; other site
1049565005878	heme binding pocket [chemical binding]; other site
1049565005879	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
1049565005880	domain interactions; other site
1049565005881	cell division modulator; Provisional; Region: PRK10113
1049565005882	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
1049565005883	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1049565005884	inner membrane protein; Provisional; Region: PRK11648
1049565005885	2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993
1049565005886	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
1049565005887	NADP binding site [chemical binding]; other site
1049565005888	homodimer interface [polypeptide binding]; other site
1049565005889	active site
1049565005890	2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826
1049565005891	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1049565005892	motif II; other site
1049565005893	YniB-like protein; Region: YniB; pfam14002
1049565005894	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1049565005895	outer membrane receptor FepA; Provisional; Region: PRK13528
1049565005896	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1049565005897	N-terminal plug; other site
1049565005898	ligand-binding site [chemical binding]; other site
1049565005899	intracellular septation protein A; Reviewed; Region: PRK00259
1049565005900	hypothetical protein; Provisional; Region: PRK02868
1049565005901	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
1049565005902	outer membrane protein W; Provisional; Region: PRK10959
1049565005903	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
1049565005904	catecholate siderophore receptor Fiu; Provisional; Region: PRK09840
1049565005905	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1049565005906	N-terminal plug; other site
1049565005907	ligand-binding site [chemical binding]; other site
1049565005908	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1049565005909	C factor cell-cell signaling protein; Provisional; Region: PRK09009
1049565005910	NAD(P) binding site [chemical binding]; other site
1049565005911	active site
1049565005912	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1049565005913	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1049565005914	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
1049565005915	putative NAD(P) binding site [chemical binding]; other site
1049565005916	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1049565005917	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1049565005918	putative DNA binding site [nucleotide binding]; other site
1049565005919	putative Zn2+ binding site [ion binding]; other site
1049565005920	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
1049565005921	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
1049565005922	substrate binding site [chemical binding]; other site
1049565005923	active site
1049565005924	catalytic residues [active]
1049565005925	heterodimer interface [polypeptide binding]; other site
1049565005926	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
1049565005927	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1049565005928	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565005929	catalytic residue [active]
1049565005930	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
1049565005931	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1049565005932	active site
1049565005933	ribulose/triose binding site [chemical binding]; other site
1049565005934	phosphate binding site [ion binding]; other site
1049565005935	substrate (anthranilate) binding pocket [chemical binding]; other site
1049565005936	product (indole) binding pocket [chemical binding]; other site
1049565005937	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
1049565005938	active site
1049565005939	bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522
1049565005940	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1049565005941	glutamine binding [chemical binding]; other site
1049565005942	catalytic triad [active]
1049565005943	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1049565005944	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1049565005945	anthranilate synthase component I; Provisional; Region: PRK13564
1049565005946	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1049565005947	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1049565005948	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
1049565005949	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
1049565005950	active site
1049565005951	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
1049565005952	hypothetical protein; Provisional; Region: PRK11630
1049565005953	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1049565005954	EamA-like transporter family; Region: EamA; pfam00892
1049565005955	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1049565005956	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565005957	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1049565005958	dimerization interface [polypeptide binding]; other site
1049565005959	substrate binding pocket [chemical binding]; other site
1049565005960	23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700
1049565005961	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1049565005962	RNA binding surface [nucleotide binding]; other site
1049565005963	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
1049565005964	probable active site [active]
1049565005965	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
1049565005966	cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986
1049565005967	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
1049565005968	Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340
1049565005969	NADP binding site [chemical binding]; other site
1049565005970	homodimer interface [polypeptide binding]; other site
1049565005971	active site
1049565005972	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
1049565005973	putative inner membrane peptidase; Provisional; Region: PRK11778
1049565005974	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
1049565005975	tandem repeat interface [polypeptide binding]; other site
1049565005976	oligomer interface [polypeptide binding]; other site
1049565005977	active site residues [active]
1049565005978	hypothetical protein; Provisional; Region: PRK11037
1049565005979	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
1049565005980	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1049565005981	active site
1049565005982	interdomain interaction site; other site
1049565005983	putative metal-binding site [ion binding]; other site
1049565005984	nucleotide binding site [chemical binding]; other site
1049565005985	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1049565005986	domain I; other site
1049565005987	DNA binding groove [nucleotide binding]
1049565005988	phosphate binding site [ion binding]; other site
1049565005989	domain II; other site
1049565005990	domain III; other site
1049565005991	nucleotide binding site [chemical binding]; other site
1049565005992	catalytic site [active]
1049565005993	domain IV; other site
1049565005994	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1049565005995	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1049565005996	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
1049565005997	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
1049565005998	transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681
1049565005999	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565006000	The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443
1049565006001	substrate binding site [chemical binding]; other site
1049565006002	putative dimerization interface [polypeptide binding]; other site
1049565006003	aconitate hydratase; Validated; Region: PRK09277
1049565006004	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
1049565006005	substrate binding site [chemical binding]; other site
1049565006006	ligand binding site [chemical binding]; other site
1049565006007	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
1049565006008	substrate binding site [chemical binding]; other site
1049565006009	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
1049565006010	dimerization interface [polypeptide binding]; other site
1049565006011	active site
1049565006012	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1049565006013	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
1049565006014	active site
1049565006015	Predicted membrane protein [Function unknown]; Region: COG3771
1049565006016	tetratricopeptide repeat protein; Provisional; Region: PRK11788
1049565006017	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1049565006018	binding surface
1049565006019	TPR motif; other site
1049565006020	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1049565006021	binding surface
1049565006022	TPR motif; other site
1049565006023	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1049565006024	active site
1049565006025	dimer interface [polypeptide binding]; other site
1049565006026	translation initiation factor Sui1; Validated; Region: PRK06824
1049565006027	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
1049565006028	putative rRNA binding site [nucleotide binding]; other site
1049565006029	lipoprotein; Provisional; Region: PRK10540
1049565006030	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1049565006031	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1049565006032	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1049565006033	hypothetical protein; Provisional; Region: PRK13658
1049565006034	exoribonuclease II; Provisional; Region: PRK05054
1049565006035	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
1049565006036	RNB domain; Region: RNB; pfam00773
1049565006037	S1 RNA binding domain; Region: S1; pfam00575
1049565006038	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731
1049565006039	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1049565006040	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984
1049565006041	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
1049565006042	NAD binding site [chemical binding]; other site
1049565006043	homotetramer interface [polypeptide binding]; other site
1049565006044	homodimer interface [polypeptide binding]; other site
1049565006045	substrate binding site [chemical binding]; other site
1049565006046	active site
1049565006047	HutD; Region: HutD; pfam05962
1049565006048	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1049565006049	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
1049565006050	Na binding site [ion binding]; other site
1049565006051	antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112
1049565006052	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1049565006053	Walker A/P-loop; other site
1049565006054	ATP binding site [chemical binding]; other site
1049565006055	Q-loop/lid; other site
1049565006056	ABC transporter signature motif; other site
1049565006057	Walker B; other site
1049565006058	D-loop; other site
1049565006059	H-loop/switch region; other site
1049565006060	antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093
1049565006061	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1049565006062	Walker A/P-loop; other site
1049565006063	ATP binding site [chemical binding]; other site
1049565006064	Q-loop/lid; other site
1049565006065	ABC transporter signature motif; other site
1049565006066	Walker B; other site
1049565006067	D-loop; other site
1049565006068	H-loop/switch region; other site
1049565006069	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1049565006070	antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111
1049565006071	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1049565006072	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565006073	dimer interface [polypeptide binding]; other site
1049565006074	conserved gate region; other site
1049565006075	putative PBP binding loops; other site
1049565006076	ABC-ATPase subunit interface; other site
1049565006077	antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110
1049565006078	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565006079	dimer interface [polypeptide binding]; other site
1049565006080	conserved gate region; other site
1049565006081	putative PBP binding loops; other site
1049565006082	ABC-ATPase subunit interface; other site
1049565006083	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1049565006084	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
1049565006085	peptide binding site [polypeptide binding]; other site
1049565006086	atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262
1049565006087	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1049565006088	putative NAD(P) binding site [chemical binding]; other site
1049565006089	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1049565006090	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1049565006091	salt bridge; other site
1049565006092	non-specific DNA binding site [nucleotide binding]; other site
1049565006093	sequence-specific DNA binding site [nucleotide binding]; other site
1049565006094	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565006095	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1049565006096	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565006097	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664
1049565006098	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1049565006099	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
1049565006100	metal binding site [ion binding]; metal-binding site
1049565006101	putative dimer interface [polypeptide binding]; other site
1049565006102	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1049565006103	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565006104	putative substrate translocation pore; other site
1049565006105	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565006106	putative substrate translocation pore; other site
1049565006107	phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608
1049565006108	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1049565006109	Walker A motif; other site
1049565006110	ATP binding site [chemical binding]; other site
1049565006111	Walker B motif; other site
1049565006112	arginine finger; other site
1049565006113	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1049565006114	phage shock protein PspA; Provisional; Region: PRK10698
1049565006115	phage shock protein B; Provisional; Region: pspB; PRK09458
1049565006116	DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697
1049565006117	phage shock protein C; Region: phageshock_pspC; TIGR02978
1049565006118	peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497
1049565006119	Predicted ATPase [General function prediction only]; Region: COG3106
1049565006120	hypothetical protein; Provisional; Region: PRK05415
1049565006121	Domain of unknown function (DUF697); Region: DUF697; cl12064
1049565006122	potential frameshift: common BLAST hit: gi|238894366|ref|YP_002919100.1| putative LysR family regulatory protein
1049565006123	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
1049565006124	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
1049565006125	NAD binding site [chemical binding]; other site
1049565006126	sugar binding site [chemical binding]; other site
1049565006127	divalent metal binding site [ion binding]; other site
1049565006128	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1049565006129	dimer interface [polypeptide binding]; other site
1049565006130	DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820
1049565006131	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1049565006132	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1049565006133	putative active site [active]
1049565006134	heme pocket [chemical binding]; other site
1049565006135	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1049565006136	Walker A motif; other site
1049565006137	ATP binding site [chemical binding]; other site
1049565006138	Walker B motif; other site
1049565006139	arginine finger; other site
1049565006140	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
1049565006141	Putative ammonia monooxygenase; Region: AmoA; pfam05145
1049565006142	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
1049565006143	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
1049565006144	dimer interface [polypeptide binding]; other site
1049565006145	catalytic triad [active]
1049565006146	peroxidatic and resolving cysteines [active]
1049565006147	L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129
1049565006148	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
1049565006149	active site
1049565006150	Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904
1049565006151	putative active site [active]
1049565006152	Zn binding site [ion binding]; other site
1049565006153	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
1049565006154	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1049565006155	peptide binding site [polypeptide binding]; other site
1049565006156	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565006157	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565006158	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
1049565006159	putative effector binding pocket; other site
1049565006160	putative dimerization interface [polypeptide binding]; other site
1049565006161	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
1049565006162	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565006163	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1049565006164	putative substrate translocation pore; other site
1049565006165	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1049565006166	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1049565006167	active site
1049565006168	catalytic tetrad [active]
1049565006169	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
1049565006170	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565006171	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565006172	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
1049565006173	putative effector binding pocket; other site
1049565006174	putative dimerization interface [polypeptide binding]; other site
1049565006175	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1049565006176	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1049565006177	NAD(P) binding site [chemical binding]; other site
1049565006178	active site
1049565006179	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
1049565006180	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1049565006181	Zn2+ binding site [ion binding]; other site
1049565006182	Mg2+ binding site [ion binding]; other site
1049565006183	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
1049565006184	intracellular protease, PfpI family; Region: PfpI; TIGR01382
1049565006185	conserved cys residue [active]
1049565006186	Protein of unknown function (DUF770); Region: DUF770; pfam05591
1049565006187	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517; cl05484
1049565006188	Protein of unknown function (DUF877); Region: DUF877; pfam05943
1049565006189	type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353
1049565006190	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
1049565006191	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850
1049565006192	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1049565006193	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1049565006194	ligand binding site [chemical binding]; other site
1049565006195	type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344
1049565006196	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
1049565006197	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1049565006198	Walker A motif; other site
1049565006199	ATP binding site [chemical binding]; other site
1049565006200	Walker B motif; other site
1049565006201	arginine finger; other site
1049565006202	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1049565006203	Walker A motif; other site
1049565006204	ATP binding site [chemical binding]; other site
1049565006205	Walker B motif; other site
1049565006206	Rhs element Vgr protein; Region: vgr_GE; TIGR01646
1049565006207	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
1049565006208	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
1049565006209	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
1049565006210	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
1049565006211	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
1049565006212	Protein of unknown function (DUF3304); Region: DUF3304; pfam11745
1049565006213	Protein of unknown function (DUF3304); Region: DUF3304; pfam11745
1049565006214	Protein of unknown function (DUF3304); Region: DUF3304; pfam11745
1049565006215	Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480
1049565006216	PAAR motif; Region: PAAR_motif; pfam05488
1049565006217	Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and    vesicular transport]; Region: IcmF; COG3523
1049565006218	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
1049565006219	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
1049565006220	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3515
1049565006221	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
1049565006222	type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362
1049565006223	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
1049565006224	Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947
1049565006225	Protein of unknown function (DUF1305); Region: DUF1305; pfam06996
1049565006226	Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790
1049565006227	oxidoreductase; Provisional; Region: PRK12742
1049565006228	classical (c) SDRs; Region: SDR_c; cd05233
1049565006229	NAD(P) binding site [chemical binding]; other site
1049565006230	active site
1049565006231	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1049565006232	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1049565006233	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
1049565006234	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1049565006235	NAD(P) binding site [chemical binding]; other site
1049565006236	active site
1049565006237	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
1049565006238	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565006239	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1049565006240	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
1049565006241	phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259
1049565006242	NmrA-like family; Region: NmrA; pfam05368
1049565006243	NAD(P) binding site [chemical binding]; other site
1049565006244	active site lysine
1049565006245	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565006246	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565006247	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
1049565006248	putative effector binding pocket; other site
1049565006249	putative dimerization interface [polypeptide binding]; other site
1049565006250	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565006251	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565006252	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464
1049565006253	putative substrate binding pocket [chemical binding]; other site
1049565006254	putative dimerization interface [polypeptide binding]; other site
1049565006255	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1049565006256	NmrA-like family; Region: NmrA; pfam05368
1049565006257	NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251
1049565006258	NADP binding site [chemical binding]; other site
1049565006259	active site
1049565006260	regulatory binding site [polypeptide binding]; other site
1049565006261	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1049565006262	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1049565006263	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
1049565006264	putative NAD(P) binding site [chemical binding]; other site
1049565006265	transaminase; Reviewed; Region: PRK08068
1049565006266	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1049565006267	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565006268	homodimer interface [polypeptide binding]; other site
1049565006269	catalytic residue [active]
1049565006270	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1049565006271	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1049565006272	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
1049565006273	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1049565006274	Walker A/P-loop; other site
1049565006275	ATP binding site [chemical binding]; other site
1049565006276	Q-loop/lid; other site
1049565006277	ABC transporter signature motif; other site
1049565006278	Walker B; other site
1049565006279	D-loop; other site
1049565006280	H-loop/switch region; other site
1049565006281	NIL domain; Region: NIL; pfam09383
1049565006282	ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011
1049565006283	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
1049565006284	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1049565006285	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565006286	homodimer interface [polypeptide binding]; other site
1049565006287	catalytic residue [active]
1049565006288	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1049565006289	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1049565006290	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1049565006291	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1049565006292	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
1049565006293	putative DNA binding site [nucleotide binding]; other site
1049565006294	putative Zn2+ binding site [ion binding]; other site
1049565006295	AsnC family; Region: AsnC_trans_reg; pfam01037
1049565006296	aromatic amino acid transporter; Provisional; Region: PRK10238
1049565006297	putative oxidoreductase; Provisional; Region: PRK11579
1049565006298	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1049565006299	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1049565006300	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1049565006301	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1049565006302	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1049565006303	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1049565006304	Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833
1049565006305	Cl binding site [ion binding]; other site
1049565006306	oligomer interface [polypeptide binding]; other site
1049565006307	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
1049565006308	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1049565006309	ATP binding site [chemical binding]; other site
1049565006310	Mg++ binding site [ion binding]; other site
1049565006311	motif III; other site
1049565006312	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1049565006313	nucleotide binding region [chemical binding]; other site
1049565006314	ATP-binding site [chemical binding]; other site
1049565006315	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
1049565006316	putative RNA binding site [nucleotide binding]; other site
1049565006317	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
1049565006318	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
1049565006319	Ligand Binding Site [chemical binding]; other site
1049565006320	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1049565006321	Ligand Binding Site [chemical binding]; other site
1049565006322	KTSC domain; Region: KTSC; pfam13619
1049565006323	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1049565006324	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1049565006325	trimer interface [polypeptide binding]; other site
1049565006326	eyelet of channel; other site
1049565006327	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
1049565006328	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1049565006329	dimer interface [polypeptide binding]; other site
1049565006330	PYR/PP interface [polypeptide binding]; other site
1049565006331	TPP binding site [chemical binding]; other site
1049565006332	substrate binding site [chemical binding]; other site
1049565006333	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
1049565006334	Domain of unknown function; Region: EKR; pfam10371
1049565006335	4Fe-4S binding domain; Region: Fer4_6; pfam12837
1049565006336	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1049565006337	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
1049565006338	TPP-binding site [chemical binding]; other site
1049565006339	dimer interface [polypeptide binding]; other site
1049565006340	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
1049565006341	Domain of unknown function (DUF333); Region: DUF333; pfam03891
1049565006342	META domain; Region: META; cl01245
1049565006343	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
1049565006344	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1049565006345	putative ligand binding site [chemical binding]; other site
1049565006346	putative NAD binding site [chemical binding]; other site
1049565006347	catalytic site [active]
1049565006348	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1049565006349	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1049565006350	hypothetical protein; Provisional; Region: PRK10695
1049565006351	YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617
1049565006352	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784
1049565006353	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
1049565006354	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565006355	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1049565006356	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1049565006357	NAD(P) binding site [chemical binding]; other site
1049565006358	catalytic residues [active]
1049565006359	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
1049565006360	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1049565006361	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1049565006362	hypothetical protein; Provisional; Region: PRK07490
1049565006363	intersubunit interface [polypeptide binding]; other site
1049565006364	active site
1049565006365	Zn2+ binding site [ion binding]; other site
1049565006366	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1049565006367	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1049565006368	substrate binding pocket [chemical binding]; other site
1049565006369	membrane-bound complex binding site; other site
1049565006370	hinge residues; other site
1049565006371	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
1049565006372	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565006373	dimer interface [polypeptide binding]; other site
1049565006374	conserved gate region; other site
1049565006375	putative PBP binding loops; other site
1049565006376	ABC-ATPase subunit interface; other site
1049565006377	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1049565006378	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1049565006379	Walker A/P-loop; other site
1049565006380	ATP binding site [chemical binding]; other site
1049565006381	Q-loop/lid; other site
1049565006382	ABC transporter signature motif; other site
1049565006383	Walker B; other site
1049565006384	D-loop; other site
1049565006385	H-loop/switch region; other site
1049565006386	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565006387	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565006388	The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
1049565006389	putative substrate binding pocket [chemical binding]; other site
1049565006390	dimerization interface [polypeptide binding]; other site
1049565006391	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
1049565006392	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1049565006393	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1049565006394	homotrimer interaction site [polypeptide binding]; other site
1049565006395	putative active site [active]
1049565006396	Family of unknown function (DUF1028); Region: DUF1028; pfam06267
1049565006397	acetylornithine deacetylase; Provisional; Region: PRK07522
1049565006398	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
1049565006399	metal binding site [ion binding]; metal-binding site
1049565006400	putative dimer interface [polypeptide binding]; other site
1049565006401	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
1049565006402	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1049565006403	2-enoyl thioester reductase-like; Region: ETR_like; cd05282
1049565006404	NADP binding site [chemical binding]; other site
1049565006405	dimer interface [polypeptide binding]; other site
1049565006406	tyramine oxidase; Provisional; Region: tynA; PRK14696
1049565006407	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1049565006408	Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727
1049565006409	Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728
1049565006410	Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179
1049565006411	bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563
1049565006412	N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128
1049565006413	substrate binding site [chemical binding]; other site
1049565006414	dimer interface [polypeptide binding]; other site
1049565006415	NADP binding site [chemical binding]; other site
1049565006416	catalytic residues [active]
1049565006417	MaoC_C  The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452
1049565006418	substrate binding site [chemical binding]; other site
1049565006419	phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778
1049565006420	phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156
1049565006421	phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781
1049565006422	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138
1049565006423	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
1049565006424	phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159
1049565006425	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
1049565006426	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
1049565006427	FAD binding pocket [chemical binding]; other site
1049565006428	FAD binding motif [chemical binding]; other site
1049565006429	phosphate binding motif [ion binding]; other site
1049565006430	beta-alpha-beta structure motif; other site
1049565006431	NAD(p) ribose binding residues [chemical binding]; other site
1049565006432	NAD binding pocket [chemical binding]; other site
1049565006433	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
1049565006434	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1049565006435	catalytic loop [active]
1049565006436	iron binding site [ion binding]; other site
1049565006437	enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674
1049565006438	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1049565006439	substrate binding site [chemical binding]; other site
1049565006440	oxyanion hole (OAH) forming residues; other site
1049565006441	trimer interface [polypeptide binding]; other site
1049565006442	enoyl-CoA hydratase; Provisional; Region: PRK08140
1049565006443	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1049565006444	substrate binding site [chemical binding]; other site
1049565006445	oxyanion hole (OAH) forming residues; other site
1049565006446	trimer interface [polypeptide binding]; other site
1049565006447	3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268
1049565006448	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1049565006449	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1049565006450	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1049565006451	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1049565006452	CoenzymeA binding site [chemical binding]; other site
1049565006453	subunit interaction site [polypeptide binding]; other site
1049565006454	PHB binding site; other site
1049565006455	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
1049565006456	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1049565006457	dimer interface [polypeptide binding]; other site
1049565006458	active site
1049565006459	Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913
1049565006460	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
1049565006461	active site
1049565006462	AMP binding site [chemical binding]; other site
1049565006463	homodimer interface [polypeptide binding]; other site
1049565006464	acyl-activating enzyme (AAE) consensus motif; other site
1049565006465	CoA binding site [chemical binding]; other site
1049565006466	PaaX-like protein; Region: PaaX; pfam07848
1049565006467	phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277
1049565006468	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
1049565006469	phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287
1049565006470	paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745
1049565006471	putative trimer interface [polypeptide binding]; other site
1049565006472	putative metal binding site [ion binding]; other site
1049565006473	azoreductase; Reviewed; Region: PRK00170
1049565006474	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1049565006475	ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
1049565006476	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1049565006477	ATP binding site [chemical binding]; other site
1049565006478	putative Mg++ binding site [ion binding]; other site
1049565006479	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1049565006480	nucleotide binding region [chemical binding]; other site
1049565006481	ATP-binding site [chemical binding]; other site
1049565006482	Helicase associated domain (HA2); Region: HA2; pfam04408
1049565006483	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
1049565006484	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
1049565006485	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
1049565006486	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1049565006487	S-adenosylmethionine binding site [chemical binding]; other site
1049565006488	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1049565006489	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
1049565006490	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1049565006491	HlyD family secretion protein; Region: HlyD_3; pfam13437
1049565006492	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565006493	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1049565006494	putative substrate translocation pore; other site
1049565006495	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1049565006496	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1049565006497	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565006498	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565006499	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1049565006500	dimerization interface [polypeptide binding]; other site
1049565006501	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1049565006502	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1049565006503	active site
1049565006504	catalytic tetrad [active]
1049565006505	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
1049565006506	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1049565006507	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
1049565006508	NAD(P) binding site [chemical binding]; other site
1049565006509	bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381
1049565006510	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1049565006511	inhibitor-cofactor binding pocket; inhibition site
1049565006512	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565006513	catalytic residue [active]
1049565006514	Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958
1049565006515	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
1049565006516	succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457
1049565006517	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
1049565006518	NAD(P) binding site [chemical binding]; other site
1049565006519	catalytic residues [active]
1049565006520	succinylarginine dihydrolase; Provisional; Region: PRK13281
1049565006521	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
1049565006522	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
1049565006523	active site
1049565006524	Zn binding site [ion binding]; other site
1049565006525	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
1049565006526	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565006527	metabolite-proton symporter; Region: 2A0106; TIGR00883
1049565006528	putative substrate translocation pore; other site
1049565006529	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1049565006530	putative active site [active]
1049565006531	Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088
1049565006532	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1049565006533	NAD binding site [chemical binding]; other site
1049565006534	catalytic residues [active]
1049565006535	substrate binding site [chemical binding]; other site
1049565006536	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
1049565006537	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1049565006538	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1049565006539	Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401
1049565006540	Protein of unknown function (DUF1398); Region: DUF1398; pfam07166
1049565006541	YedF is a bacterial SirA-like protein of unknown function.  SirA  (also known as UvrY,  and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422
1049565006542	CPxP  motif; other site
1049565006543	putative inner membrane protein; Provisional; Region: PRK11099
1049565006544	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
1049565006545	YdfZ protein; Region: YdfZ; pfam14001
1049565006546	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1049565006547	Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834
1049565006548	Cl binding site [ion binding]; other site
1049565006549	oligomer interface [polypeptide binding]; other site
1049565006550	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
1049565006551	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1049565006552	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565006553	homodimer interface [polypeptide binding]; other site
1049565006554	catalytic residue [active]
1049565006555	bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110
1049565006556	PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852
1049565006557	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1049565006558	active site turn [active]
1049565006559	phosphorylation site [posttranslational modification]
1049565006560	DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014
1049565006561	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1049565006562	DNA binding site [nucleotide binding]
1049565006563	domain linker motif; other site
1049565006564	Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289
1049565006565	putative dimerization interface [polypeptide binding]; other site
1049565006566	putative ligand binding site [chemical binding]; other site
1049565006567	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
1049565006568	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
1049565006569	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
1049565006570	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
1049565006571	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
1049565006572	fumarate hydratase; Provisional; Region: PRK15389
1049565006573	Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951
1049565006574	Fumarase C-terminus; Region: Fumerase_C; pfam05683
1049565006575	fumarate hydratase; Reviewed; Region: fumC; PRK00485
1049565006576	Class II fumarases; Region: Fumarase_classII; cd01362
1049565006577	active site
1049565006578	tetramer interface [polypeptide binding]; other site
1049565006579	DNA replication terminus site-binding protein; Provisional; Region: PRK02951
1049565006580	sensor protein RstB; Provisional; Region: PRK10604
1049565006581	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1049565006582	dimerization interface [polypeptide binding]; other site
1049565006583	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1049565006584	dimer interface [polypeptide binding]; other site
1049565006585	phosphorylation site [posttranslational modification]
1049565006586	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1049565006587	ATP binding site [chemical binding]; other site
1049565006588	Mg2+ binding site [ion binding]; other site
1049565006589	G-X-G motif; other site
1049565006590	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
1049565006591	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1049565006592	active site
1049565006593	phosphorylation site [posttranslational modification]
1049565006594	intermolecular recognition site; other site
1049565006595	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1049565006596	DNA binding site [nucleotide binding]
1049565006597	GlpM protein; Region: GlpM; pfam06942
1049565006598	dihydromonapterin reductase; Provisional; Region: PRK06483
1049565006599	pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357
1049565006600	NADP binding site [chemical binding]; other site
1049565006601	substrate binding pocket [chemical binding]; other site
1049565006602	active site
1049565006603	potential frameshift: common BLAST hit: gi|238894539|ref|YP_002919273.1| putative arginine/ornithine antiporter
1049565006604	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
1049565006605	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
1049565006606	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
1049565006607	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
1049565006608	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
1049565006609	ligand binding site [chemical binding]; other site
1049565006610	homodimer interface [polypeptide binding]; other site
1049565006611	NAD(P) binding site [chemical binding]; other site
1049565006612	trimer interface B [polypeptide binding]; other site
1049565006613	trimer interface A [polypeptide binding]; other site
1049565006614	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
1049565006615	pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444
1049565006616	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
1049565006617	universal stress protein UspE; Provisional; Region: PRK11175
1049565006618	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1049565006619	Ligand Binding Site [chemical binding]; other site
1049565006620	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1049565006621	Ligand Binding Site [chemical binding]; other site
1049565006622	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
1049565006623	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1049565006624	ligand binding site [chemical binding]; other site
1049565006625	flexible hinge region; other site
1049565006626	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1049565006627	putative switch regulator; other site
1049565006628	non-specific DNA interactions [nucleotide binding]; other site
1049565006629	DNA binding site [nucleotide binding]
1049565006630	sequence specific DNA binding site [nucleotide binding]; other site
1049565006631	putative cAMP binding site [chemical binding]; other site
1049565006632	O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286
1049565006633	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
1049565006634	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1049565006635	DNA binding site [nucleotide binding]
1049565006636	active site
1049565006637	putative aminobenzoyl-glutamate transporter; Provisional; Region: abgT; PRK11339
1049565006638	p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819
1049565006639	M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673
1049565006640	amidohydrolase; Region: amidohydrolases; TIGR01891
1049565006641	putative metal binding site [ion binding]; other site
1049565006642	M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665
1049565006643	amidohydrolase; Region: amidohydrolases; TIGR01891
1049565006644	putative metal binding site [ion binding]; other site
1049565006645	dimer interface [polypeptide binding]; other site
1049565006646	putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791
1049565006647	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565006648	The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418
1049565006649	putative substrate binding pocket [chemical binding]; other site
1049565006650	putative dimerization interface [polypeptide binding]; other site
1049565006651	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
1049565006652	Smr domain; Region: Smr; pfam01713
1049565006653	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
1049565006654	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1049565006655	Bacterial transcriptional regulator; Region: IclR; pfam01614
1049565006656	3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429
1049565006657	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
1049565006658	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
1049565006659	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1049565006660	dimer interface [polypeptide binding]; other site
1049565006661	active site
1049565006662	3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053
1049565006663	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
1049565006664	tetramer interface [polypeptide binding]; other site
1049565006665	active site
1049565006666	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
1049565006667	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1049565006668	4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425
1049565006669	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1049565006670	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1049565006671	fumarate hydratase; Provisional; Region: PRK15389
1049565006672	Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951
1049565006673	Fumarase C-terminus; Region: Fumerase_C; pfam05683
1049565006674	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1049565006675	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
1049565006676	transmembrane helices; other site
1049565006677	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1049565006678	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
1049565006679	putative active site [active]
1049565006680	putative FMN binding site [chemical binding]; other site
1049565006681	putative substrate binding site [chemical binding]; other site
1049565006682	putative catalytic residue [active]
1049565006683	FMN-binding domain; Region: FMN_bind; cl01081
1049565006684	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
1049565006685	L-aspartate oxidase; Provisional; Region: PRK06175
1049565006686	Predicted oxidoreductase [General function prediction only]; Region: COG3573
1049565006687	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
1049565006688	ApbE family; Region: ApbE; pfam02424
1049565006689	DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430
1049565006690	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1049565006691	active site
1049565006692	phosphorylation site [posttranslational modification]
1049565006693	intermolecular recognition site; other site
1049565006694	dimerization interface [polypeptide binding]; other site
1049565006695	sensory histidine kinase DcuS; Provisional; Region: PRK11086
1049565006696	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1049565006697	putative active site [active]
1049565006698	heme pocket [chemical binding]; other site
1049565006699	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1049565006700	ATP binding site [chemical binding]; other site
1049565006701	Mg2+ binding site [ion binding]; other site
1049565006702	G-X-G motif; other site
1049565006703	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
1049565006704	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
1049565006705	putative active site [active]
1049565006706	malate:quinone oxidoreductase; Validated; Region: PRK05257
1049565006707	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
1049565006708	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565006709	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565006710	The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416
1049565006711	putative dimerization interface [polypeptide binding]; other site
1049565006712	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1049565006713	malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131
1049565006714	phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293
1049565006715	Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620
1049565006716	he Auxin Efflux Carrier (AEC) Family; Region: 2a69; TIGR00946
1049565006717	Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; pfam06833
1049565006718	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189
1049565006719	malonate decarboxylase subunit delta; Provisional; Region: PRK01220
1049565006720	triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237
1049565006721	malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110
1049565006722	Coenzyme A transferase; Region: CoA_trans; cl17247
1049565006723	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287
1049565006724	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1049565006725	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1049565006726	Integrase core domain; Region: rve; pfam00665
1049565006727	Integrase core domain; Region: rve_3; pfam13683
1049565006728	multidrug efflux system protein MdtJ; Provisional; Region: PRK10452
1049565006729	multidrug efflux system protein MdtI; Provisional; Region: PRK10650
1049565006730	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
1049565006731	potential frameshift: common BLAST hit: gi|238894592|ref|YP_002919326.1| putative Zn-dependent carboxypeptidase
1049565006732	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1049565006733	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565006734	putative substrate translocation pore; other site
1049565006735	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
1049565006736	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565006737	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
1049565006738	dimerization interface [polypeptide binding]; other site
1049565006739	substrate binding pocket [chemical binding]; other site
1049565006740	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
1049565006741	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1049565006742	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1049565006743	nucleotide binding site [chemical binding]; other site
1049565006744	putative dithiobiotin synthetase; Provisional; Region: PRK12374
1049565006745	AAA domain; Region: AAA_26; pfam13500
1049565006746	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
1049565006747	Cl- selectivity filter; other site
1049565006748	Cl- binding residues [ion binding]; other site
1049565006749	pore gating glutamate residue; other site
1049565006750	dimer interface [polypeptide binding]; other site
1049565006751	twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621
1049565006752	DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976
1049565006753	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
1049565006754	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
1049565006755	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
1049565006756	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
1049565006757	putative [Fe4-S4] binding site [ion binding]; other site
1049565006758	putative molybdopterin cofactor binding site [chemical binding]; other site
1049565006759	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
1049565006760	putative molybdopterin cofactor binding site; other site
1049565006761	Protein of unknown function (DUF1161); Region: DUF1161; pfam06649
1049565006762	lipoprotein; Reviewed; Region: PRK02939
1049565006763	spermidine N1-acetyltransferase; Provisional; Region: PRK15130
1049565006764	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1049565006765	Coenzyme A binding pocket [chemical binding]; other site
1049565006766	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1049565006767	hypothetical protein; Provisional; Region: PRK13659
1049565006768	hypothetical protein; Provisional; Region: PRK02237
1049565006769	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565006770	D-galactonate transporter; Region: 2A0114; TIGR00893
1049565006771	putative substrate translocation pore; other site
1049565006772	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
1049565006773	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1049565006774	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1049565006775	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1049565006776	Ligand Binding Site [chemical binding]; other site
1049565006777	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1049565006778	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1049565006779	DNA-binding site [nucleotide binding]; DNA binding site
1049565006780	FCD domain; Region: FCD; pfam07729
1049565006781	malonic semialdehyde reductase; Provisional; Region: PRK10538
1049565006782	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
1049565006783	putative NAD(P) binding site [chemical binding]; other site
1049565006784	homodimer interface [polypeptide binding]; other site
1049565006785	homotetramer interface [polypeptide binding]; other site
1049565006786	active site
1049565006787	dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280
1049565006788	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
1049565006789	active site
1049565006790	Zn binding site [ion binding]; other site
1049565006791	SnoaL-like domain; Region: SnoaL_2; pfam12680
1049565006792	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565006793	Helix-turn-helix domain; Region: HTH_18; pfam12833
1049565006794	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565006795	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1049565006796	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1049565006797	DNA binding residues [nucleotide binding]
1049565006798	dimerization interface [polypeptide binding]; other site
1049565006799	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1049565006800	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
1049565006801	putative dimer interface [polypeptide binding]; other site
1049565006802	hypothetical protein; Validated; Region: PRK03657
1049565006803	Sensors of blue-light using FAD; Region: BLUF; smart01034
1049565006804	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1049565006805	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1049565006806	DNA binding residues [nucleotide binding]
1049565006807	dimerization interface [polypeptide binding]; other site
1049565006808	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1049565006809	right oriC-binding transcriptional activator; Provisional; Region: PRK15121
1049565006810	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565006811	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
1049565006812	putative transporter; Provisional; Region: PRK09821
1049565006813	GntP family permease; Region: GntP_permease; pfam02447
1049565006814	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
1049565006815	putative aldolase; Validated; Region: PRK08130
1049565006816	active site
1049565006817	intersubunit interface [polypeptide binding]; other site
1049565006818	Zn2+ binding site [ion binding]; other site
1049565006819	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
1049565006820	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1049565006821	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1049565006822	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1049565006823	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1049565006824	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1049565006825	beta-lactamase TEM; Provisional; Region: PRK15442
1049565006826	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
1049565006827	Predicted ATPase [General function prediction only]; Region: COG4637
1049565006828	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1049565006829	Walker A/P-loop; other site
1049565006830	ATP binding site [chemical binding]; other site
1049565006831	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1049565006832	ABC transporter signature motif; other site
1049565006833	Walker B; other site
1049565006834	D-loop; other site
1049565006835	H-loop/switch region; other site
1049565006836	LacY proton/sugar symporter; Region: LacY_symp; pfam01306
1049565006837	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565006838	beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525
1049565006839	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1049565006840	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1049565006841	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1049565006842	Beta galactosidase small chain; Region: Bgal_small_N; pfam02929
1049565006843	lac repressor; Reviewed; Region: lacI; PRK09526
1049565006844	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1049565006845	DNA binding site [nucleotide binding]
1049565006846	domain linker motif; other site
1049565006847	Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574
1049565006848	ligand binding site [chemical binding]; other site
1049565006849	dimerization interface (open form) [polypeptide binding]; other site
1049565006850	dimerization interface (closed form) [polypeptide binding]; other site
1049565006851	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1049565006852	Coenzyme A binding pocket [chemical binding]; other site
1049565006853	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
1049565006854	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
1049565006855	conserved cys residue [active]
1049565006856	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565006857	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565006858	Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521
1049565006859	active site residue [active]
1049565006860	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1049565006861	substrate binding site [chemical binding]; other site
1049565006862	THF binding site; other site
1049565006863	zinc-binding site [ion binding]; other site
1049565006864	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1049565006865	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
1049565006866	putative ligand binding site [chemical binding]; other site
1049565006867	HEAT repeats; Region: HEAT_2; pfam13646
1049565006868	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1049565006869	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1049565006870	TM-ABC transporter signature motif; other site
1049565006871	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1049565006872	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1049565006873	TM-ABC transporter signature motif; other site
1049565006874	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
1049565006875	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1049565006876	Walker A/P-loop; other site
1049565006877	ATP binding site [chemical binding]; other site
1049565006878	Q-loop/lid; other site
1049565006879	ABC transporter signature motif; other site
1049565006880	Walker B; other site
1049565006881	D-loop; other site
1049565006882	H-loop/switch region; other site
1049565006883	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
1049565006884	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1049565006885	Walker A/P-loop; other site
1049565006886	ATP binding site [chemical binding]; other site
1049565006887	Q-loop/lid; other site
1049565006888	ABC transporter signature motif; other site
1049565006889	Walker B; other site
1049565006890	D-loop; other site
1049565006891	H-loop/switch region; other site
1049565006892	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1049565006893	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1049565006894	non-specific DNA binding site [nucleotide binding]; other site
1049565006895	salt bridge; other site
1049565006896	sequence-specific DNA binding site [nucleotide binding]; other site
1049565006897	2TM domain; Region: 2TM; pfam13239
1049565006898	putative transporter; Provisional; Region: PRK10054
1049565006899	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565006900	putative substrate translocation pore; other site
1049565006901	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
1049565006902	MarB protein; Region: MarB; pfam13999
1049565006903	DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511
1049565006904	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565006905	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565006906	DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512
1049565006907	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1049565006908	inner membrane protein; Provisional; Region: PRK10995
1049565006909	potential frameshift: common BLAST hit: gi|238894658|ref|YP_002919392.1| sugar efflux transporter
1049565006910	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
1049565006911	short chain dehydrogenase; Provisional; Region: PRK07577
1049565006912	classical (c) SDRs; Region: SDR_c; cd05233
1049565006913	NAD(P) binding site [chemical binding]; other site
1049565006914	active site
1049565006915	Domain of unknown function (DUF386); Region: DUF386; cl01047
1049565006916	Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692
1049565006917	BNR repeat-like domain; Region: BNR_2; pfam13088
1049565006918	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1049565006919	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
1049565006920	Na binding site [ion binding]; other site
1049565006921	dihydrodipicolinate synthase; Region: dapA; TIGR00674
1049565006922	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1049565006923	inhibitor site; inhibition site
1049565006924	active site
1049565006925	dimer interface [polypeptide binding]; other site
1049565006926	catalytic residue [active]
1049565006927	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
1049565006928	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1049565006929	active site
1049565006930	NAD binding site [chemical binding]; other site
1049565006931	metal binding site [ion binding]; metal-binding site
1049565006932	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
1049565006933	4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371
1049565006934	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
1049565006935	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1049565006936	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1049565006937	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1049565006938	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
1049565006939	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1049565006940	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
1049565006941	NAD binding site [chemical binding]; other site
1049565006942	dimer interface [polypeptide binding]; other site
1049565006943	substrate binding site [chemical binding]; other site
1049565006944	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1049565006945	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
1049565006946	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565006947	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
1049565006948	putative dimerization interface [polypeptide binding]; other site
1049565006949	putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968
1049565006950	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
1049565006951	NAD(P) binding site [chemical binding]; other site
1049565006952	catalytic residues [active]
1049565006953	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
1049565006954	glutaminase; Provisional; Region: PRK00971
1049565006955	Domain of unknown function (DUF4186); Region: DUF4186; pfam13811
1049565006956	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1049565006957	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1049565006958	metal binding site [ion binding]; metal-binding site
1049565006959	active site
1049565006960	I-site; other site
1049565006961	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1049565006962	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1049565006963	Coenzyme A binding pocket [chemical binding]; other site
1049565006964	altronate oxidoreductase; Provisional; Region: PRK03643
1049565006965	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1049565006966	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1049565006967	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1049565006968	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1049565006969	Coenzyme A binding pocket [chemical binding]; other site
1049565006970	Protein of unknown function (DUF796); Region: DUF796; cl01226
1049565006971	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
1049565006972	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
1049565006973	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
1049565006974	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1049565006975	S-adenosylmethionine binding site [chemical binding]; other site
1049565006976	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565006977	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1049565006978	putative substrate translocation pore; other site
1049565006979	Protein of unknown function (DUF1228); Region: DUF1228; pfam06779
1049565006980	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565006981	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565006982	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1049565006983	dimerization interface [polypeptide binding]; other site
1049565006984	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
1049565006985	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1049565006986	FMN binding site [chemical binding]; other site
1049565006987	substrate binding site [chemical binding]; other site
1049565006988	putative catalytic residue [active]
1049565006989	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565006990	dimer interface [polypeptide binding]; other site
1049565006991	conserved gate region; other site
1049565006992	ABC-ATPase subunit interface; other site
1049565006993	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1049565006994	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1049565006995	Walker A/P-loop; other site
1049565006996	ATP binding site [chemical binding]; other site
1049565006997	Q-loop/lid; other site
1049565006998	ABC transporter signature motif; other site
1049565006999	Walker B; other site
1049565007000	D-loop; other site
1049565007001	H-loop/switch region; other site
1049565007002	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1049565007003	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1049565007004	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
1049565007005	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
1049565007006	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
1049565007007	Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905
1049565007008	Cupin domain; Region: Cupin_2; cl17218
1049565007009	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
1049565007010	Cupin; Region: Cupin_6; pfam12852
1049565007011	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1049565007012	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565007013	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565007014	ribonucleoside transporter; Reviewed; Region: nepI; PRK10213
1049565007015	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565007016	putative substrate translocation pore; other site
1049565007017	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
1049565007018	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1049565007019	FMN-binding pocket [chemical binding]; other site
1049565007020	flavin binding motif; other site
1049565007021	phosphate binding motif [ion binding]; other site
1049565007022	beta-alpha-beta structure motif; other site
1049565007023	NAD binding pocket [chemical binding]; other site
1049565007024	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1049565007025	catalytic loop [active]
1049565007026	iron binding site [ion binding]; other site
1049565007027	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1049565007028	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
1049565007029	[2Fe-2S] cluster binding site [ion binding]; other site
1049565007030	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1049565007031	hydrophobic ligand binding site; other site
1049565007032	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565007033	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565007034	LysR substrate binding domain; Region: LysR_substrate; pfam03466
1049565007035	dimerization interface [polypeptide binding]; other site
1049565007036	hypothetical protein; Provisional; Region: PRK07236
1049565007037	FAD binding domain; Region: FAD_binding_3; pfam01494
1049565007038	xanthine permease; Region: pbuX; TIGR03173
1049565007039	OHCU decarboxylase; Region: UraD_2; TIGR03180
1049565007040	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
1049565007041	active site
1049565007042	homotetramer interface [polypeptide binding]; other site
1049565007043	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1049565007044	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1049565007045	non-specific DNA binding site [nucleotide binding]; other site
1049565007046	salt bridge; other site
1049565007047	sequence-specific DNA binding site [nucleotide binding]; other site
1049565007048	HipA N-terminal domain; Region: Couple_hipA; pfam13657
1049565007049	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
1049565007050	HipA-like N-terminal domain; Region: HipA_N; pfam07805
1049565007051	HipA-like C-terminal domain; Region: HipA_C; pfam07804
1049565007052	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
1049565007053	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
1049565007054	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
1049565007055	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
1049565007056	PapC N-terminal domain; Region: PapC_N; pfam13954
1049565007057	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
1049565007058	PapC C-terminal domain; Region: PapC_C; pfam13953
1049565007059	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
1049565007060	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
1049565007061	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
1049565007062	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
1049565007063	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1049565007064	active site
1049565007065	Protein of unknown function (DUF3423); Region: DUF3423; pfam11903
1049565007066	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1049565007067	PAS domain; Region: PAS_9; pfam13426
1049565007068	putative active site [active]
1049565007069	heme pocket [chemical binding]; other site
1049565007070	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1049565007071	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1049565007072	metal binding site [ion binding]; metal-binding site
1049565007073	active site
1049565007074	I-site; other site
1049565007075	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1049565007076	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1049565007077	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1049565007078	active site
1049565007079	phosphorylation site [posttranslational modification]
1049565007080	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
1049565007081	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565007082	putative substrate translocation pore; other site
1049565007083	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565007084	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
1049565007085	Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298
1049565007086	NAD binding site [chemical binding]; other site
1049565007087	sugar binding site [chemical binding]; other site
1049565007088	divalent metal binding site [ion binding]; other site
1049565007089	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
1049565007090	dimer interface [polypeptide binding]; other site
1049565007091	PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005
1049565007092	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1049565007093	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1049565007094	active site turn [active]
1049565007095	phosphorylation site [posttranslational modification]
1049565007096	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1049565007097	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1049565007098	DNA-binding site [nucleotide binding]; DNA binding site
1049565007099	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1049565007100	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1049565007101	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565007102	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565007103	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
1049565007104	putative dimerization interface [polypeptide binding]; other site
1049565007105	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1049565007106	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1049565007107	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
1049565007108	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
1049565007109	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1049565007110	glycerate kinase; Region: TIGR00045
1049565007111	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565007112	putative substrate translocation pore; other site
1049565007113	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1049565007114	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
1049565007115	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
1049565007116	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565007117	putative substrate translocation pore; other site
1049565007118	putative acyltransferase; Provisional; Region: PRK05790
1049565007119	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1049565007120	dimer interface [polypeptide binding]; other site
1049565007121	active site
1049565007122	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1049565007123	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1049565007124	NAD(P) binding site [chemical binding]; other site
1049565007125	active site
1049565007126	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
1049565007127	Coenzyme A transferase; Region: CoA_trans; smart00882
1049565007128	Coenzyme A transferase; Region: CoA_trans; cl17247
1049565007129	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1049565007130	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1049565007131	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
1049565007132	acyl-activating enzyme (AAE) consensus motif; other site
1049565007133	acyl-activating enzyme (AAE) consensus motif; other site
1049565007134	putative AMP binding site [chemical binding]; other site
1049565007135	putative active site [active]
1049565007136	putative CoA binding site [chemical binding]; other site
1049565007137	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1049565007138	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1049565007139	Berberine and berberine like; Region: BBE; pfam08031
1049565007140	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
1049565007141	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565007142	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565007143	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1049565007144	dimerization interface [polypeptide binding]; other site
1049565007145	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
1049565007146	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1049565007147	Walker A/P-loop; other site
1049565007148	ATP binding site [chemical binding]; other site
1049565007149	Q-loop/lid; other site
1049565007150	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1049565007151	ABC transporter signature motif; other site
1049565007152	Walker B; other site
1049565007153	D-loop; other site
1049565007154	H-loop/switch region; other site
1049565007155	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1049565007156	AAA domain; Region: AAA_21; pfam13304
1049565007157	Walker A/P-loop; other site
1049565007158	ATP binding site [chemical binding]; other site
1049565007159	Q-loop/lid; other site
1049565007160	ABC transporter signature motif; other site
1049565007161	Walker B; other site
1049565007162	D-loop; other site
1049565007163	H-loop/switch region; other site
1049565007164	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565007165	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565007166	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1049565007167	dimerization interface [polypeptide binding]; other site
1049565007168	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
1049565007169	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1049565007170	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1049565007171	active site
1049565007172	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
1049565007173	Strictosidine synthase; Region: Str_synth; pfam03088
1049565007174	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1049565007175	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1049565007176	active site
1049565007177	catalytic tetrad [active]
1049565007178	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1049565007179	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1049565007180	active site
1049565007181	catalytic tetrad [active]
1049565007182	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565007183	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565007184	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
1049565007185	putative effector binding pocket; other site
1049565007186	putative dimerization interface [polypeptide binding]; other site
1049565007187	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
1049565007188	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1049565007189	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1049565007190	active site
1049565007191	phosphorylation site [posttranslational modification]
1049565007192	intermolecular recognition site; other site
1049565007193	dimerization interface [polypeptide binding]; other site
1049565007194	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1049565007195	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1049565007196	Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192
1049565007197	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1049565007198	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1049565007199	dimer interface [polypeptide binding]; other site
1049565007200	phosphorylation site [posttranslational modification]
1049565007201	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1049565007202	ATP binding site [chemical binding]; other site
1049565007203	Mg2+ binding site [ion binding]; other site
1049565007204	G-X-G motif; other site
1049565007205	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1049565007206	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1049565007207	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
1049565007208	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565007209	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565007210	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
1049565007211	BON domain; Region: BON; pfam04972
1049565007212	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1049565007213	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1049565007214	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1049565007215	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
1049565007216	BtpA family; Region: BtpA; cl00440
1049565007217	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1049565007218	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1049565007219	substrate binding site [chemical binding]; other site
1049565007220	ATP binding site [chemical binding]; other site
1049565007221	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1049565007222	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
1049565007223	ligand binding site [chemical binding]; other site
1049565007224	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1049565007225	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1049565007226	DNA binding site [nucleotide binding]
1049565007227	domain linker motif; other site
1049565007228	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_11; cd06293
1049565007229	putative dimerization interface [polypeptide binding]; other site
1049565007230	putative ligand binding site [chemical binding]; other site
1049565007231	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1049565007232	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1049565007233	Walker A/P-loop; other site
1049565007234	ATP binding site [chemical binding]; other site
1049565007235	Q-loop/lid; other site
1049565007236	ABC transporter signature motif; other site
1049565007237	Walker B; other site
1049565007238	D-loop; other site
1049565007239	H-loop/switch region; other site
1049565007240	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1049565007241	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1049565007242	TM-ABC transporter signature motif; other site
1049565007243	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
1049565007244	active site
1049565007245	substrate binding pocket [chemical binding]; other site
1049565007246	homodimer interaction site [polypeptide binding]; other site
1049565007247	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
1049565007248	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588
1049565007249	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
1049565007250	metal binding site [ion binding]; metal-binding site
1049565007251	dimer interface [polypeptide binding]; other site
1049565007252	TolA C-terminal; Region: TolA; pfam06519
1049565007253	TolA protein; Region: tolA_full; TIGR02794
1049565007254	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1049565007255	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565007256	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565007257	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1049565007258	dimerization interface [polypeptide binding]; other site
1049565007259	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565007260	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565007261	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1049565007262	putative effector binding pocket; other site
1049565007263	dimerization interface [polypeptide binding]; other site
1049565007264	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565007265	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1049565007266	putative substrate translocation pore; other site
1049565007267	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1049565007268	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1049565007269	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
1049565007270	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1049565007271	active site
1049565007272	P-loop; other site
1049565007273	phosphorylation site [posttranslational modification]
1049565007274	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1049565007275	active site
1049565007276	phosphorylation site [posttranslational modification]
1049565007277	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
1049565007278	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1049565007279	substrate binding site [chemical binding]; other site
1049565007280	hexamer interface [polypeptide binding]; other site
1049565007281	metal binding site [ion binding]; metal-binding site
1049565007282	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
1049565007283	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
1049565007284	active site
1049565007285	P-loop; other site
1049565007286	phosphorylation site [posttranslational modification]
1049565007287	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1049565007288	active site
1049565007289	phosphorylation site [posttranslational modification]
1049565007290	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1049565007291	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1049565007292	DNA binding site [nucleotide binding]
1049565007293	domain linker motif; other site
1049565007294	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
1049565007295	putative dimerization interface [polypeptide binding]; other site
1049565007296	putative ligand binding site [chemical binding]; other site
1049565007297	oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259
1049565007298	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565007299	putative substrate translocation pore; other site
1049565007300	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1049565007301	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1049565007302	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1049565007303	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1049565007304	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1049565007305	EamA-like transporter family; Region: EamA; cl17759
1049565007306	EamA-like transporter family; Region: EamA; pfam00892
1049565007307	putative sialic acid transporter; Region: 2A0112; TIGR00891
1049565007308	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565007309	putative substrate translocation pore; other site
1049565007310	hypothetical protein; Provisional; Region: PRK09897
1049565007311	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
1049565007312	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1049565007313	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
1049565007314	active site
1049565007315	FMN binding site [chemical binding]; other site
1049565007316	substrate binding site [chemical binding]; other site
1049565007317	homotetramer interface [polypeptide binding]; other site
1049565007318	catalytic residue [active]
1049565007319	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565007320	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565007321	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
1049565007322	putative effector binding pocket; other site
1049565007323	putative dimerization interface [polypeptide binding]; other site
1049565007324	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
1049565007325	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1049565007326	FMN binding site [chemical binding]; other site
1049565007327	substrate binding site [chemical binding]; other site
1049565007328	putative catalytic residue [active]
1049565007329	allantoate amidohydrolase; Reviewed; Region: PRK09290
1049565007330	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
1049565007331	active site
1049565007332	metal binding site [ion binding]; metal-binding site
1049565007333	dimer interface [polypeptide binding]; other site
1049565007334	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
1049565007335	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1049565007336	catalytic residue [active]
1049565007337	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1049565007338	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1049565007339	Walker A/P-loop; other site
1049565007340	ATP binding site [chemical binding]; other site
1049565007341	Q-loop/lid; other site
1049565007342	ABC transporter signature motif; other site
1049565007343	Walker B; other site
1049565007344	D-loop; other site
1049565007345	H-loop/switch region; other site
1049565007346	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565007347	dimer interface [polypeptide binding]; other site
1049565007348	conserved gate region; other site
1049565007349	putative PBP binding loops; other site
1049565007350	ABC-ATPase subunit interface; other site
1049565007351	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1049565007352	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565007353	dimer interface [polypeptide binding]; other site
1049565007354	conserved gate region; other site
1049565007355	putative PBP binding loops; other site
1049565007356	ABC-ATPase subunit interface; other site
1049565007357	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1049565007358	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1049565007359	substrate binding pocket [chemical binding]; other site
1049565007360	membrane-bound complex binding site; other site
1049565007361	hinge residues; other site
1049565007362	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1049565007363	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1049565007364	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
1049565007365	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
1049565007366	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
1049565007367	Protein of unknown function (DUF4089); Region: DUF4089; pfam13318
1049565007368	amidase; Provisional; Region: PRK09201
1049565007369	Amidase; Region: Amidase; pfam01425
1049565007370	Protein of unknown function (DUF3225); Region: DUF3225; pfam11533
1049565007371	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1049565007372	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1049565007373	Coenzyme A binding pocket [chemical binding]; other site
1049565007374	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
1049565007375	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1049565007376	Predicted transcriptional regulators [Transcription]; Region: COG1733
1049565007377	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1049565007378	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
1049565007379	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1049565007380	HlyD family secretion protein; Region: HlyD_3; pfam13437
1049565007381	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1049565007382	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565007383	putative substrate translocation pore; other site
1049565007384	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565007385	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333
1049565007386	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1049565007387	dimer interface [polypeptide binding]; other site
1049565007388	active site
1049565007389	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
1049565007390	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1049565007391	Helix-turn-helix domain; Region: HTH_18; pfam12833
1049565007392	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
1049565007393	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
1049565007394	catalytic triad [active]
1049565007395	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1049565007396	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1049565007397	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1049565007398	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1049565007399	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565007400	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565007401	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1049565007402	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
1049565007403	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
1049565007404	active site
1049565007405	catalytic site [active]
1049565007406	tetramer interface [polypeptide binding]; other site
1049565007407	Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126
1049565007408	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1049565007409	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1049565007410	DNA-binding site [nucleotide binding]; DNA binding site
1049565007411	FCD domain; Region: FCD; pfam07729
1049565007412	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555
1049565007413	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
1049565007414	Na binding site [ion binding]; other site
1049565007415	putative substrate binding site [chemical binding]; other site
1049565007416	guanine deaminase; Provisional; Region: PRK09228
1049565007417	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
1049565007418	active site
1049565007419	Protein of unknown function (DUF2931); Region: DUF2931; pfam11153
1049565007420	PAAR motif; Region: PAAR_motif; pfam05488
1049565007421	Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480
1049565007422	potential frameshift: common BLAST hit: gi|288935373|ref|YP_003439432.1| diguanylate cyclase with PAS/PAC sensor
1049565007423	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1049565007424	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1049565007425	DNA binding site [nucleotide binding]
1049565007426	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1049565007427	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1049565007428	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
1049565007429	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1049565007430	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1049565007431	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1049565007432	Protein of unknown function (DUF4056); Region: DUF4056; pfam13265
1049565007433	Putative transcription activator [Transcription]; Region: TenA; COG0819
1049565007434	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1049565007435	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1049565007436	Walker A/P-loop; other site
1049565007437	ATP binding site [chemical binding]; other site
1049565007438	Q-loop/lid; other site
1049565007439	ABC transporter signature motif; other site
1049565007440	Walker B; other site
1049565007441	D-loop; other site
1049565007442	H-loop/switch region; other site
1049565007443	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1049565007444	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565007445	dimer interface [polypeptide binding]; other site
1049565007446	conserved gate region; other site
1049565007447	ABC-ATPase subunit interface; other site
1049565007448	NMT1/THI5 like; Region: NMT1; pfam09084
1049565007449	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
1049565007450	diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931
1049565007451	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1049565007452	inhibitor-cofactor binding pocket; inhibition site
1049565007453	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565007454	catalytic residue [active]
1049565007455	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
1049565007456	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565007457	catalytic residue [active]
1049565007458	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565007459	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565007460	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1049565007461	dimerization interface [polypeptide binding]; other site
1049565007462	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1049565007463	Helix-turn-helix domain; Region: HTH_28; pfam13518
1049565007464	Helix-turn-helix domain; Region: HTH_28; pfam13518
1049565007465	putative transposase OrfB; Reviewed; Region: PHA02517
1049565007466	HTH-like domain; Region: HTH_21; pfam13276
1049565007467	Integrase core domain; Region: rve; pfam00665
1049565007468	Integrase core domain; Region: rve_2; pfam13333
1049565007469	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1049565007470	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
1049565007471	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
1049565007472	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1049565007473	catalytic residues [active]
1049565007474	HAMP domain; Region: HAMP; pfam00672
1049565007475	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1049565007476	dimer interface [polypeptide binding]; other site
1049565007477	phosphorylation site [posttranslational modification]
1049565007478	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1049565007479	ATP binding site [chemical binding]; other site
1049565007480	Mg2+ binding site [ion binding]; other site
1049565007481	G-X-G motif; other site
1049565007482	osmolarity response regulator; Provisional; Region: ompR; PRK09468
1049565007483	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1049565007484	active site
1049565007485	phosphorylation site [posttranslational modification]
1049565007486	intermolecular recognition site; other site
1049565007487	dimerization interface [polypeptide binding]; other site
1049565007488	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1049565007489	DNA binding site [nucleotide binding]
1049565007490	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1049565007491	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
1049565007492	active site
1049565007493	dimer interface [polypeptide binding]; other site
1049565007494	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
1049565007495	coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284
1049565007496	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
1049565007497	coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
1049565007498	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
1049565007499	pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079
1049565007500	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
1049565007501	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1049565007502	FeS/SAM binding site; other site
1049565007503	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
1049565007504	coenzyme PQQ biosynthesis probable peptidase PqqF; Region: PQQ_syn_pqqF; TIGR02110
1049565007505	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1049565007506	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
1049565007507	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
1049565007508	catalytic triad [active]
1049565007509	penicillin-binding protein 2; Provisional; Region: PRK10795
1049565007510	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1049565007511	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1049565007512	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1049565007513	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
1049565007514	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
1049565007515	heme binding site [chemical binding]; other site
1049565007516	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
1049565007517	heme binding site [chemical binding]; other site
1049565007518	Predicted ATPase [General function prediction only]; Region: COG1485
1049565007519	magnesium transport protein MgtC; Provisional; Region: PRK15385
1049565007520	MgtC family; Region: MgtC; pfam02308
1049565007521	benzoate transport; Region: 2A0115; TIGR00895
1049565007522	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565007523	putative substrate translocation pore; other site
1049565007524	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565007525	putative substrate translocation pore; other site
1049565007526	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
1049565007527	methionine cluster; other site
1049565007528	active site
1049565007529	phosphorylation site [posttranslational modification]
1049565007530	metal binding site [ion binding]; metal-binding site
1049565007531	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565007532	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565007533	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1049565007534	dimerization interface [polypeptide binding]; other site
1049565007535	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
1049565007536	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
1049565007537	putative molybdopterin cofactor binding site [chemical binding]; other site
1049565007538	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
1049565007539	putative molybdopterin cofactor binding site; other site
1049565007540	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544
1049565007541	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1049565007542	Cation efflux family; Region: Cation_efflux; pfam01545
1049565007543	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1049565007544	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1049565007545	substrate binding pocket [chemical binding]; other site
1049565007546	membrane-bound complex binding site; other site
1049565007547	hinge residues; other site
1049565007548	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
1049565007549	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
1049565007550	hypothetical protein; Provisional; Region: PRK10053
1049565007551	Predicted membrane protein [Function unknown]; Region: COG2323
1049565007552	short chain dehydrogenase; Provisional; Region: PRK07109
1049565007553	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
1049565007554	putative NAD(P) binding site [chemical binding]; other site
1049565007555	active site
1049565007556	trehalose synthase; Region: treS_nterm; TIGR02456
1049565007557	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
1049565007558	active site
1049565007559	catalytic site [active]
1049565007560	Domain of unknown function (DUF892); Region: DUF892; pfam05974
1049565007561	General stress protein [General function prediction only]; Region: GsiB; COG3729
1049565007562	oxidoreductase; Provisional; Region: PRK06128
1049565007563	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
1049565007564	NAD binding site [chemical binding]; other site
1049565007565	metal binding site [ion binding]; metal-binding site
1049565007566	active site
1049565007567	Protein of unknown function (DUF2543); Region: DUF2543; pfam10820
1049565007568	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565007569	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565007570	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1049565007571	putative effector binding pocket; other site
1049565007572	dimerization interface [polypeptide binding]; other site
1049565007573	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1049565007574	30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057
1049565007575	malate dehydrogenase; Provisional; Region: PRK13529
1049565007576	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1049565007577	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
1049565007578	NAD(P) binding site [chemical binding]; other site
1049565007579	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
1049565007580	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1049565007581	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1049565007582	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1049565007583	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1049565007584	MarR family; Region: MarR_2; pfam12802
1049565007585	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1049565007586	Coenzyme A binding pocket [chemical binding]; other site
1049565007587	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
1049565007588	dimer interface [polypeptide binding]; other site
1049565007589	substrate binding site [chemical binding]; other site
1049565007590	metal binding sites [ion binding]; metal-binding site
1049565007591	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
1049565007592	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
1049565007593	NAD binding site [chemical binding]; other site
1049565007594	substrate binding site [chemical binding]; other site
1049565007595	catalytic Zn binding site [ion binding]; other site
1049565007596	tetramer interface [polypeptide binding]; other site
1049565007597	structural Zn binding site [ion binding]; other site
1049565007598	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1049565007599	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492
1049565007600	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1049565007601	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565007602	dimer interface [polypeptide binding]; other site
1049565007603	conserved gate region; other site
1049565007604	ABC-ATPase subunit interface; other site
1049565007605	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1049565007606	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565007607	ABC-ATPase subunit interface; other site
1049565007608	putative PBP binding loops; other site
1049565007609	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1049565007610	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1049565007611	Walker A/P-loop; other site
1049565007612	ATP binding site [chemical binding]; other site
1049565007613	Q-loop/lid; other site
1049565007614	ABC transporter signature motif; other site
1049565007615	Walker B; other site
1049565007616	D-loop; other site
1049565007617	H-loop/switch region; other site
1049565007618	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1049565007619	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1049565007620	Walker A/P-loop; other site
1049565007621	ATP binding site [chemical binding]; other site
1049565007622	Q-loop/lid; other site
1049565007623	ABC transporter signature motif; other site
1049565007624	Walker B; other site
1049565007625	D-loop; other site
1049565007626	H-loop/switch region; other site
1049565007627	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1049565007628	putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027
1049565007629	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
1049565007630	CMD domain protein, Avi_7170 family; Region: CMD_Avi_7170; TIGR04029
1049565007631	alkylhydroperoxidase domain protein, Avi_7169 family; Region: perox_Avi_7169; TIGR04030
1049565007632	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
1049565007633	MFS transport protein AraJ; Provisional; Region: PRK10091
1049565007634	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565007635	putative substrate translocation pore; other site
1049565007636	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1049565007637	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1049565007638	active site
1049565007639	metal binding site [ion binding]; metal-binding site
1049565007640	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
1049565007641	formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179
1049565007642	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
1049565007643	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
1049565007644	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
1049565007645	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1049565007646	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1049565007647	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1049565007648	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
1049565007649	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
1049565007650	molybdopterin cofactor binding site; other site
1049565007651	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1049565007652	aromatic amino acid exporter; Provisional; Region: PRK11689
1049565007653	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823
1049565007654	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937
1049565007655	putative NAD(P) binding site [chemical binding]; other site
1049565007656	active site
1049565007657	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
1049565007658	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1049565007659	catalytic loop [active]
1049565007660	iron binding site [ion binding]; other site
1049565007661	Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209
1049565007662	FAD binding pocket [chemical binding]; other site
1049565007663	FAD binding motif [chemical binding]; other site
1049565007664	phosphate binding motif [ion binding]; other site
1049565007665	beta-alpha-beta structure motif; other site
1049565007666	NAD binding pocket [chemical binding]; other site
1049565007667	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
1049565007668	inter-subunit interface; other site
1049565007669	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
1049565007670	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1049565007671	iron-sulfur cluster [ion binding]; other site
1049565007672	[2Fe-2S] cluster binding site [ion binding]; other site
1049565007673	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
1049565007674	putative alpha subunit interface [polypeptide binding]; other site
1049565007675	putative active site [active]
1049565007676	putative substrate binding site [chemical binding]; other site
1049565007677	Fe binding site [ion binding]; other site
1049565007678	catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439
1049565007679	Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460
1049565007680	dimer interface [polypeptide binding]; other site
1049565007681	active site
1049565007682	muconolactone delta-isomerase; Region: muco_delta; TIGR03221
1049565007683	Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318
1049565007684	muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534
1049565007685	octamer interface [polypeptide binding]; other site
1049565007686	active site
1049565007687	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
1049565007688	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1049565007689	Bacterial transcriptional regulator; Region: IclR; pfam01614
1049565007690	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
1049565007691	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565007692	putative substrate translocation pore; other site
1049565007693	TetR family transcriptional regulator; Provisional; Region: PRK14996
1049565007694	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1049565007695	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
1049565007696	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
1049565007697	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
1049565007698	[4Fe-4S] binding site [ion binding]; other site
1049565007699	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1049565007700	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1049565007701	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1049565007702	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
1049565007703	molybdopterin cofactor binding site; other site
1049565007704	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
1049565007705	nitrate reductase 2 subunit delta; Provisional; Region: PRK15054
1049565007706	respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351
1049565007707	N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047
1049565007708	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1049565007709	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565007710	dimer interface [polypeptide binding]; other site
1049565007711	conserved gate region; other site
1049565007712	putative PBP binding loops; other site
1049565007713	ABC-ATPase subunit interface; other site
1049565007714	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1049565007715	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1049565007716	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
1049565007717	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1049565007718	Walker A/P-loop; other site
1049565007719	ATP binding site [chemical binding]; other site
1049565007720	Q-loop/lid; other site
1049565007721	ABC transporter signature motif; other site
1049565007722	Walker B; other site
1049565007723	D-loop; other site
1049565007724	H-loop/switch region; other site
1049565007725	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1049565007726	4-oxalocrotonate tautomerase; Provisional; Region: PRK01271
1049565007727	active site 1 [active]
1049565007728	dimer interface [polypeptide binding]; other site
1049565007729	hexamer interface [polypeptide binding]; other site
1049565007730	active site 2 [active]
1049565007731	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
1049565007732	C-terminal domain interface [polypeptide binding]; other site
1049565007733	GSH binding site (G-site) [chemical binding]; other site
1049565007734	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1049565007735	dimer interface [polypeptide binding]; other site
1049565007736	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
1049565007737	dimer interface [polypeptide binding]; other site
1049565007738	N-terminal domain interface [polypeptide binding]; other site
1049565007739	substrate binding pocket (H-site) [chemical binding]; other site
1049565007740	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1049565007741	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1049565007742	substrate binding pocket [chemical binding]; other site
1049565007743	membrane-bound complex binding site; other site
1049565007744	hinge residues; other site
1049565007745	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1049565007746	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1049565007747	Walker A/P-loop; other site
1049565007748	ATP binding site [chemical binding]; other site
1049565007749	Q-loop/lid; other site
1049565007750	ABC transporter signature motif; other site
1049565007751	Walker B; other site
1049565007752	D-loop; other site
1049565007753	H-loop/switch region; other site
1049565007754	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1049565007755	potential frameshift: common BLAST hit: gi|152970451|ref|YP_001335560.1| glutamate/aspartate ABC transporter membrane protein
1049565007756	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1049565007757	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1049565007758	Coenzyme A binding pocket [chemical binding]; other site
1049565007759	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1049565007760	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1049565007761	substrate binding pocket [chemical binding]; other site
1049565007762	membrane-bound complex binding site; other site
1049565007763	hinge residues; other site
1049565007764	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1049565007765	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1049565007766	active site
1049565007767	non-prolyl cis peptide bond; other site
1049565007768	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1049565007769	M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669
1049565007770	metal binding site [ion binding]; metal-binding site
1049565007771	dimer interface [polypeptide binding]; other site
1049565007772	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1049565007773	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1049565007774	AAA domain; Region: AAA_17; pfam13207
1049565007775	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565007776	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565007777	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
1049565007778	putative effector binding pocket; other site
1049565007779	putative dimerization interface [polypeptide binding]; other site
1049565007780	L-asparagine permease; Provisional; Region: PRK15049
1049565007781	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
1049565007782	Uncharacterized conserved protein [Function unknown]; Region: COG3391
1049565007783	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1049565007784	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1049565007785	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1049565007786	N-terminal plug; other site
1049565007787	ligand-binding site [chemical binding]; other site
1049565007788	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
1049565007789	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
1049565007790	active site
1049565007791	hypothetical protein; Provisional; Region: PRK09981
1049565007792	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
1049565007793	active site
1049565007794	tetramer interface [polypeptide binding]; other site
1049565007795	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
1049565007796	Prostaglandin dehydrogenases; Region: PGDH; cd05288
1049565007797	NAD(P) binding site [chemical binding]; other site
1049565007798	substrate binding site [chemical binding]; other site
1049565007799	dimer interface [polypeptide binding]; other site
1049565007800	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1049565007801	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1049565007802	sequence-specific DNA binding site [nucleotide binding]; other site
1049565007803	salt bridge; other site
1049565007804	Cupin domain; Region: Cupin_2; pfam07883
1049565007805	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1049565007806	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1049565007807	Coenzyme A binding pocket [chemical binding]; other site
1049565007808	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
1049565007809	Protein of unknown function (DUF2526); Region: DUF2526; pfam10735
1049565007810	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1049565007811	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
1049565007812	peptide binding site [polypeptide binding]; other site
1049565007813	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1049565007814	Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105
1049565007815	NAD(P) binding site [chemical binding]; other site
1049565007816	catalytic residues [active]
1049565007817	PGAP1-like protein; Region: PGAP1; pfam07819
1049565007818	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1049565007819	Protein of unknown function (DUF2566); Region: DUF2566; pfam10753
1049565007820	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
1049565007821	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
1049565007822	tetrameric interface [polypeptide binding]; other site
1049565007823	NAD binding site [chemical binding]; other site
1049565007824	catalytic residues [active]
1049565007825	substrate binding site [chemical binding]; other site
1049565007826	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1049565007827	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1049565007828	putative PBP binding loops; other site
1049565007829	dimer interface [polypeptide binding]; other site
1049565007830	ABC-ATPase subunit interface; other site
1049565007831	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565007832	dimer interface [polypeptide binding]; other site
1049565007833	conserved gate region; other site
1049565007834	putative PBP binding loops; other site
1049565007835	ABC-ATPase subunit interface; other site
1049565007836	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1049565007837	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1049565007838	Walker A/P-loop; other site
1049565007839	ATP binding site [chemical binding]; other site
1049565007840	Q-loop/lid; other site
1049565007841	ABC transporter signature motif; other site
1049565007842	Walker B; other site
1049565007843	D-loop; other site
1049565007844	H-loop/switch region; other site
1049565007845	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1049565007846	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1049565007847	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1049565007848	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1049565007849	DNA-binding site [nucleotide binding]; DNA binding site
1049565007850	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1049565007851	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565007852	homodimer interface [polypeptide binding]; other site
1049565007853	catalytic residue [active]
1049565007854	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1049565007855	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1049565007856	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1049565007857	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1049565007858	Protein of unknown function (DUF2474); Region: DUF2474; pfam10617
1049565007859	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1049565007860	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1049565007861	Peptidase family U32; Region: Peptidase_U32; pfam01136
1049565007862	Collagenase; Region: DUF3656; pfam12392
1049565007863	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1049565007864	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1049565007865	non-specific DNA binding site [nucleotide binding]; other site
1049565007866	salt bridge; other site
1049565007867	sequence-specific DNA binding site [nucleotide binding]; other site
1049565007868	Cupin domain; Region: Cupin_2; pfam07883
1049565007869	Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135
1049565007870	benzoate transporter; Region: benE; TIGR00843
1049565007871	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565007872	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1049565007873	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565007874	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1049565007875	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
1049565007876	tellurite resistance protein TehB; Provisional; Region: PRK11207
1049565007877	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1049565007878	S-adenosylmethionine binding site [chemical binding]; other site
1049565007879	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
1049565007880	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324
1049565007881	gating phenylalanine in ion channel; other site
1049565007882	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1049565007883	putative trimer interface [polypeptide binding]; other site
1049565007884	putative CoA binding site [chemical binding]; other site
1049565007885	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208
1049565007886	putative trimer interface [polypeptide binding]; other site
1049565007887	putative CoA binding site [chemical binding]; other site
1049565007888	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1049565007889	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1049565007890	Coenzyme A binding pocket [chemical binding]; other site
1049565007891	Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131
1049565007892	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
1049565007893	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
1049565007894	Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278
1049565007895	catalytic Zn binding site [ion binding]; other site
1049565007896	NAD binding site [chemical binding]; other site
1049565007897	structural Zn binding site [ion binding]; other site
1049565007898	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
1049565007899	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1049565007900	substrate binding pocket [chemical binding]; other site
1049565007901	catalytic triad [active]
1049565007902	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383
1049565007903	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383
1049565007904	Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464
1049565007905	heterodimer interface [polypeptide binding]; other site
1049565007906	multimer interface [polypeptide binding]; other site
1049565007907	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
1049565007908	active site
1049565007909	Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
1049565007910	Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463
1049565007911	heterodimer interface [polypeptide binding]; other site
1049565007912	active site
1049565007913	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
1049565007914	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565007915	The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435
1049565007916	putative dimerization interface [polypeptide binding]; other site
1049565007917	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
1049565007918	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
1049565007919	Trp docking motif [polypeptide binding]; other site
1049565007920	putative active site [active]
1049565007921	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
1049565007922	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
1049565007923	substrate binding site [chemical binding]; other site
1049565007924	catalytic Zn binding site [ion binding]; other site
1049565007925	NAD binding site [chemical binding]; other site
1049565007926	structural Zn binding site [ion binding]; other site
1049565007927	dimer interface [polypeptide binding]; other site
1049565007928	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
1049565007929	putative metal binding site [ion binding]; other site
1049565007930	putative homodimer interface [polypeptide binding]; other site
1049565007931	putative homotetramer interface [polypeptide binding]; other site
1049565007932	putative homodimer-homodimer interface [polypeptide binding]; other site
1049565007933	putative allosteric switch controlling residues; other site
1049565007934	cytochrome b561; Provisional; Region: PRK11513
1049565007935	Predicted transcriptional regulators [Transcription]; Region: COG1733
1049565007936	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1049565007937	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1049565007938	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
1049565007939	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
1049565007940	active site
1049565007941	purine riboside binding site [chemical binding]; other site
1049565007942	putative oxidoreductase; Provisional; Region: PRK11579
1049565007943	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1049565007944	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1049565007945	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
1049565007946	beta-galactosidase; Region: BGL; TIGR03356
1049565007947	oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391
1049565007948	Protein of unknown function (DUF2569); Region: DUF2569; pfam10754
1049565007949	electron transport complex protein RsxA; Provisional; Region: PRK05151
1049565007950	electron transport complex protein RnfB; Provisional; Region: PRK05113
1049565007951	Putative Fe-S cluster; Region: FeS; cl17515
1049565007952	4Fe-4S binding domain; Region: Fer4; cl02805
1049565007953	Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656
1049565007954	SLBB domain; Region: SLBB; pfam10531
1049565007955	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1049565007956	electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816
1049565007957	electron transport complex protein RnfG; Validated; Region: PRK01908
1049565007958	electron transport complex RsxE subunit; Provisional; Region: PRK12405
1049565007959	endonuclease III; Provisional; Region: PRK10702
1049565007960	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1049565007961	minor groove reading motif; other site
1049565007962	helix-hairpin-helix signature motif; other site
1049565007963	substrate binding pocket [chemical binding]; other site
1049565007964	active site
1049565007965	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
1049565007966	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
1049565007967	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565007968	putative substrate translocation pore; other site
1049565007969	POT family; Region: PTR2; pfam00854
1049565007970	glutathionine S-transferase; Provisional; Region: PRK10542
1049565007971	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
1049565007972	C-terminal domain interface [polypeptide binding]; other site
1049565007973	GSH binding site (G-site) [chemical binding]; other site
1049565007974	dimer interface [polypeptide binding]; other site
1049565007975	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
1049565007976	N-terminal domain interface [polypeptide binding]; other site
1049565007977	dimer interface [polypeptide binding]; other site
1049565007978	substrate binding pocket (H-site) [chemical binding]; other site
1049565007979	pyridoxamine kinase; Validated; Region: PRK05756
1049565007980	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
1049565007981	dimer interface [polypeptide binding]; other site
1049565007982	pyridoxal binding site [chemical binding]; other site
1049565007983	ATP binding site [chemical binding]; other site
1049565007984	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1049565007985	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1049565007986	active site
1049565007987	HIGH motif; other site
1049565007988	dimer interface [polypeptide binding]; other site
1049565007989	KMSKS motif; other site
1049565007990	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1049565007991	RNA binding surface [nucleotide binding]; other site
1049565007992	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
1049565007993	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1049565007994	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
1049565007995	lysozyme inhibitor; Provisional; Region: PRK11372
1049565007996	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
1049565007997	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
1049565007998	Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133
1049565007999	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1049565008000	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1049565008001	metal binding site [ion binding]; metal-binding site
1049565008002	active site
1049565008003	I-site; other site
1049565008004	transcriptional regulator SlyA; Provisional; Region: PRK03573
1049565008005	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1049565008006	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
1049565008007	p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559
1049565008008	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1049565008009	HlyD family secretion protein; Region: HlyD_3; pfam13437
1049565008010	Fusaric acid resistance protein family; Region: FUSC; pfam04632
1049565008011	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1049565008012	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
1049565008013	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
1049565008014	E-class dimer interface [polypeptide binding]; other site
1049565008015	P-class dimer interface [polypeptide binding]; other site
1049565008016	active site
1049565008017	Cu2+ binding site [ion binding]; other site
1049565008018	Zn2+ binding site [ion binding]; other site
1049565008019	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1049565008020	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1049565008021	active site
1049565008022	catalytic tetrad [active]
1049565008023	Predicted Fe-S protein [General function prediction only]; Region: COG3313
1049565008024	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1049565008025	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1049565008026	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1049565008027	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
1049565008028	FMN binding site [chemical binding]; other site
1049565008029	active site
1049565008030	substrate binding site [chemical binding]; other site
1049565008031	catalytic residue [active]
1049565008032	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1049565008033	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
1049565008034	dimer interface [polypeptide binding]; other site
1049565008035	active site
1049565008036	metal binding site [ion binding]; metal-binding site
1049565008037	glutathione binding site [chemical binding]; other site
1049565008038	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
1049565008039	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
1049565008040	dimer interface [polypeptide binding]; other site
1049565008041	catalytic site [active]
1049565008042	putative active site [active]
1049565008043	putative substrate binding site [chemical binding]; other site
1049565008044	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
1049565008045	putative GSH binding site [chemical binding]; other site
1049565008046	catalytic residues [active]
1049565008047	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1049565008048	NlpC/P60 family; Region: NLPC_P60; pfam00877
1049565008049	DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219
1049565008050	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565008051	superoxide dismutase; Provisional; Region: PRK10543
1049565008052	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1049565008053	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1049565008054	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1049565008055	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565008056	putative substrate translocation pore; other site
1049565008057	DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703
1049565008058	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1049565008059	DNA binding site [nucleotide binding]
1049565008060	domain linker motif; other site
1049565008061	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
1049565008062	dimerization interface [polypeptide binding]; other site
1049565008063	ligand binding site [chemical binding]; other site
1049565008064	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
1049565008065	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565008066	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1049565008067	dimerization interface [polypeptide binding]; other site
1049565008068	putative transporter; Provisional; Region: PRK11043
1049565008069	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565008070	putative substrate translocation pore; other site
1049565008071	cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705
1049565008072	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1049565008073	S-adenosylmethionine binding site [chemical binding]; other site
1049565008074	riboflavin synthase subunit alpha; Provisional; Region: PRK13020
1049565008075	Lumazine binding domain; Region: Lum_binding; pfam00677
1049565008076	Lumazine binding domain; Region: Lum_binding; pfam00677
1049565008077	multidrug efflux protein; Reviewed; Region: PRK01766
1049565008078	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
1049565008079	cation binding site [ion binding]; other site
1049565008080	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
1049565008081	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
1049565008082	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1049565008083	NADP binding site [chemical binding]; other site
1049565008084	active site
1049565008085	steroid binding site; other site
1049565008086	Cupin; Region: Cupin_6; pfam12852
1049565008087	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1049565008088	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565008089	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
1049565008090	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565008091	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1049565008092	dimerization interface [polypeptide binding]; other site
1049565008093	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1049565008094	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
1049565008095	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
1049565008096	active site clefts [active]
1049565008097	zinc binding site [ion binding]; other site
1049565008098	dimer interface [polypeptide binding]; other site
1049565008099	LysE type translocator; Region: LysE; cl00565
1049565008100	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1049565008101	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1049565008102	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1049565008103	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241
1049565008104	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1049565008105	putative metal binding site [ion binding]; other site
1049565008106	Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845
1049565008107	Chloramphenicol acetyltransferase; Region: CAT; cl02008
1049565008108	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1049565008109	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
1049565008110	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1049565008111	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565008112	dimer interface [polypeptide binding]; other site
1049565008113	conserved gate region; other site
1049565008114	putative PBP binding loops; other site
1049565008115	ABC-ATPase subunit interface; other site
1049565008116	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1049565008117	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1049565008118	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565008119	dimer interface [polypeptide binding]; other site
1049565008120	conserved gate region; other site
1049565008121	putative PBP binding loops; other site
1049565008122	ABC-ATPase subunit interface; other site
1049565008123	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1049565008124	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1049565008125	Walker A/P-loop; other site
1049565008126	ATP binding site [chemical binding]; other site
1049565008127	Q-loop/lid; other site
1049565008128	ABC transporter signature motif; other site
1049565008129	Walker B; other site
1049565008130	D-loop; other site
1049565008131	H-loop/switch region; other site
1049565008132	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1049565008133	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
1049565008134	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1049565008135	Walker A/P-loop; other site
1049565008136	ATP binding site [chemical binding]; other site
1049565008137	Q-loop/lid; other site
1049565008138	ABC transporter signature motif; other site
1049565008139	Walker B; other site
1049565008140	D-loop; other site
1049565008141	H-loop/switch region; other site
1049565008142	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1049565008143	Domain of unknown function (DUF3315); Region: DUF3315; cl02275
1049565008144	DinB family; Region: DinB; cl17821
1049565008145	DinB superfamily; Region: DinB_2; pfam12867
1049565008146	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565008147	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1049565008148	putative substrate translocation pore; other site
1049565008149	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565008150	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565008151	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476
1049565008152	putative effector binding pocket; other site
1049565008153	putative dimerization interface [polypeptide binding]; other site
1049565008154	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1049565008155	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
1049565008156	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1049565008157	NAD(P) binding site [chemical binding]; other site
1049565008158	active site
1049565008159	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1049565008160	active site
1049565008161	substrate binding site [chemical binding]; other site
1049565008162	Phosphotransferase enzyme family; Region: APH; pfam01636
1049565008163	ATP binding site [chemical binding]; other site
1049565008164	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
1049565008165	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1049565008166	inhibitor-cofactor binding pocket; inhibition site
1049565008167	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565008168	catalytic residue [active]
1049565008169	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1049565008170	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1049565008171	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1049565008172	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
1049565008173	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
1049565008174	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
1049565008175	amidohydrolase; Provisional; Region: PRK12393
1049565008176	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
1049565008177	active site
1049565008178	putative substrate binding pocket [chemical binding]; other site
1049565008179	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1049565008180	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565008181	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565008182	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1049565008183	dimerization interface [polypeptide binding]; other site
1049565008184	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
1049565008185	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1049565008186	FMN-binding pocket [chemical binding]; other site
1049565008187	flavin binding motif; other site
1049565008188	phosphate binding motif [ion binding]; other site
1049565008189	beta-alpha-beta structure motif; other site
1049565008190	NAD binding pocket [chemical binding]; other site
1049565008191	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1049565008192	catalytic loop [active]
1049565008193	iron binding site [ion binding]; other site
1049565008194	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1049565008195	Amidohydrolase; Region: Amidohydro_4; pfam13147
1049565008196	active site
1049565008197	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1049565008198	homotrimer interaction site [polypeptide binding]; other site
1049565008199	putative active site [active]
1049565008200	Creatinine amidohydrolase; Region: Creatininase; pfam02633
1049565008201	NMT1/THI5 like; Region: NMT1; pfam09084
1049565008202	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1049565008203	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1049565008204	Walker A/P-loop; other site
1049565008205	ATP binding site [chemical binding]; other site
1049565008206	Q-loop/lid; other site
1049565008207	ABC transporter signature motif; other site
1049565008208	Walker B; other site
1049565008209	D-loop; other site
1049565008210	H-loop/switch region; other site
1049565008211	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1049565008212	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565008213	dimer interface [polypeptide binding]; other site
1049565008214	conserved gate region; other site
1049565008215	putative PBP binding loops; other site
1049565008216	ABC-ATPase subunit interface; other site
1049565008217	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1049565008218	FAD binding domain; Region: FAD_binding_4; pfam01565
1049565008219	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
1049565008220	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
1049565008221	Chromate transporter; Region: Chromate_transp; pfam02417
1049565008222	Chromate resistance exported protein; Region: Chrome_Resist; pfam09828
1049565008223	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565008224	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1049565008225	putative substrate translocation pore; other site
1049565008226	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
1049565008227	active site 1 [active]
1049565008228	dimer interface [polypeptide binding]; other site
1049565008229	hexamer interface [polypeptide binding]; other site
1049565008230	active site 2 [active]
1049565008231	Predicted transcriptional regulators [Transcription]; Region: COG1733
1049565008232	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1049565008233	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
1049565008234	putative substrate translocation pore; other site
1049565008235	Protein of unknown function (DUF535); Region: DUF535; cl01128
1049565008236	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565008237	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565008238	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
1049565008239	putative dimerization interface [polypeptide binding]; other site
1049565008240	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
1049565008241	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
1049565008242	putative acyltransferase; Provisional; Region: PRK05790
1049565008243	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1049565008244	dimer interface [polypeptide binding]; other site
1049565008245	active site
1049565008246	3-hydroxybutyryl-CoA dehydrogenase; Region: PLN02545
1049565008247	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1049565008248	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1049565008249	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
1049565008250	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
1049565008251	d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940
1049565008252	NAD binding site [chemical binding]; other site
1049565008253	homotetramer interface [polypeptide binding]; other site
1049565008254	homodimer interface [polypeptide binding]; other site
1049565008255	substrate binding site [chemical binding]; other site
1049565008256	active site
1049565008257	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
1049565008258	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565008259	The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451
1049565008260	putative dimerization interface [polypeptide binding]; other site
1049565008261	putative substrate binding pocket [chemical binding]; other site
1049565008262	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
1049565008263	acetolactate synthase; Reviewed; Region: PRK08617
1049565008264	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1049565008265	PYR/PP interface [polypeptide binding]; other site
1049565008266	dimer interface [polypeptide binding]; other site
1049565008267	TPP binding site [chemical binding]; other site
1049565008268	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1049565008269	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
1049565008270	TPP-binding site [chemical binding]; other site
1049565008271	dimer interface [polypeptide binding]; other site
1049565008272	acetoin reductase; Validated; Region: PRK08643
1049565008273	meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366
1049565008274	NAD binding site [chemical binding]; other site
1049565008275	homotetramer interface [polypeptide binding]; other site
1049565008276	homodimer interface [polypeptide binding]; other site
1049565008277	active site
1049565008278	substrate binding site [chemical binding]; other site
1049565008279	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
1049565008280	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1049565008281	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
1049565008282	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1049565008283	ABC transporter transmembrane region; Region: ABC_membrane_3; pfam13748
1049565008284	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1049565008285	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1049565008286	active site
1049565008287	phosphorylation site [posttranslational modification]
1049565008288	intermolecular recognition site; other site
1049565008289	dimerization interface [polypeptide binding]; other site
1049565008290	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1049565008291	DNA binding site [nucleotide binding]
1049565008292	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1049565008293	HAMP domain; Region: HAMP; pfam00672
1049565008294	dimerization interface [polypeptide binding]; other site
1049565008295	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1049565008296	dimer interface [polypeptide binding]; other site
1049565008297	phosphorylation site [posttranslational modification]
1049565008298	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1049565008299	ATP binding site [chemical binding]; other site
1049565008300	Mg2+ binding site [ion binding]; other site
1049565008301	G-X-G motif; other site
1049565008302	TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305
1049565008303	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
1049565008304	putative dimer interface [polypeptide binding]; other site
1049565008305	catalytic triad [active]
1049565008306	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
1049565008307	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
1049565008308	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
1049565008309	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
1049565008310	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1049565008311	catalytic residues [active]
1049565008312	central insert; other site
1049565008313	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
1049565008314	CcmE; Region: CcmE; cl00994
1049565008315	Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114
1049565008316	heme exporter protein CcmC; Region: ccmC; TIGR01191
1049565008317	heme exporter protein CcmB; Region: ccmB; TIGR01190
1049565008318	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
1049565008319	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1049565008320	Walker A/P-loop; other site
1049565008321	ATP binding site [chemical binding]; other site
1049565008322	Q-loop/lid; other site
1049565008323	ABC transporter signature motif; other site
1049565008324	Walker B; other site
1049565008325	D-loop; other site
1049565008326	H-loop/switch region; other site
1049565008327	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1049565008328	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1049565008329	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1049565008330	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
1049565008331	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
1049565008332	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1049565008333	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
1049565008334	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
1049565008335	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1049565008336	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1049565008337	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1049565008338	Walker A/P-loop; other site
1049565008339	ATP binding site [chemical binding]; other site
1049565008340	Q-loop/lid; other site
1049565008341	ABC transporter signature motif; other site
1049565008342	Walker B; other site
1049565008343	D-loop; other site
1049565008344	H-loop/switch region; other site
1049565008345	potential frameshift: common BLAST hit: gi|288935057|ref|YP_003439116.1| binding-protein-dependent transporters inner membrane component
1049565008346	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1049565008347	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1049565008348	putative dehydrogenase; Provisional; Region: PRK10098
1049565008349	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
1049565008350	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
1049565008351	[4Fe-4S] binding site [ion binding]; other site
1049565008352	molybdopterin cofactor binding site; other site
1049565008353	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790
1049565008354	molybdopterin cofactor binding site; other site
1049565008355	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1049565008356	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
1049565008357	metal binding site [ion binding]; metal-binding site
1049565008358	putative dimer interface [polypeptide binding]; other site
1049565008359	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
1049565008360	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1049565008361	multidrug efflux system protein MdtM; Provisional; Region: PRK15403
1049565008362	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565008363	putative substrate translocation pore; other site
1049565008364	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
1049565008365	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1049565008366	Protein of unknown function (DUF1062); Region: DUF1062; cl01786
1049565008367	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1049565008368	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1049565008369	Walker A/P-loop; other site
1049565008370	ATP binding site [chemical binding]; other site
1049565008371	Q-loop/lid; other site
1049565008372	ABC transporter signature motif; other site
1049565008373	Walker B; other site
1049565008374	D-loop; other site
1049565008375	H-loop/switch region; other site
1049565008376	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1049565008377	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565008378	dimer interface [polypeptide binding]; other site
1049565008379	conserved gate region; other site
1049565008380	putative PBP binding loops; other site
1049565008381	ABC-ATPase subunit interface; other site
1049565008382	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1049565008383	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1049565008384	substrate binding pocket [chemical binding]; other site
1049565008385	membrane-bound complex binding site; other site
1049565008386	hinge residues; other site
1049565008387	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1049565008388	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1049565008389	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cd04795
1049565008390	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1049565008391	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1049565008392	siderophore binding site; other site
1049565008393	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1049565008394	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1049565008395	ABC-ATPase subunit  interface; other site
1049565008396	dimer interface [polypeptide binding]; other site
1049565008397	putative PBP binding regions; other site
1049565008398	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1049565008399	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1049565008400	ABC-ATPase subunit  interface; other site
1049565008401	dimer interface [polypeptide binding]; other site
1049565008402	putative PBP binding regions; other site
1049565008403	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1049565008404	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1049565008405	Walker A/P-loop; other site
1049565008406	ATP binding site [chemical binding]; other site
1049565008407	Q-loop/lid; other site
1049565008408	ABC transporter signature motif; other site
1049565008409	Walker B; other site
1049565008410	D-loop; other site
1049565008411	H-loop/switch region; other site
1049565008412	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1049565008413	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1049565008414	N-terminal plug; other site
1049565008415	ligand-binding site [chemical binding]; other site
1049565008416	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1049565008417	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1049565008418	Walker A/P-loop; other site
1049565008419	ATP binding site [chemical binding]; other site
1049565008420	Q-loop/lid; other site
1049565008421	ABC transporter signature motif; other site
1049565008422	Walker B; other site
1049565008423	D-loop; other site
1049565008424	H-loop/switch region; other site
1049565008425	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1049565008426	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565008427	dimer interface [polypeptide binding]; other site
1049565008428	conserved gate region; other site
1049565008429	putative PBP binding loops; other site
1049565008430	ABC-ATPase subunit interface; other site
1049565008431	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1049565008432	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1049565008433	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1049565008434	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1049565008435	membrane-bound complex binding site; other site
1049565008436	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1049565008437	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1049565008438	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1049565008439	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
1049565008440	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
1049565008441	dimer interface [polypeptide binding]; other site
1049565008442	active site
1049565008443	non-prolyl cis peptide bond; other site
1049565008444	insertion regions; other site
1049565008445	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565008446	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565008447	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1049565008448	dimerization interface [polypeptide binding]; other site
1049565008449	Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553
1049565008450	Member of the Rhodanese Homology Domain superfamily, repeat 1. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 1st repeat which does not contain the putative...; Region: 4RHOD_Repeat_1; cd01532
1049565008451	active site residue [active]
1049565008452	Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533
1049565008453	active site residue [active]
1049565008454	Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534
1049565008455	active site residue [active]
1049565008456	Member of the Rhodanese Homology Domain superfamily, repeat 4. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 4th repeat which, in general, contains the putative...; Region: 4RHOD_Repeat_4; cd01535
1049565008457	active site residue [active]
1049565008458	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
1049565008459	putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551
1049565008460	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
1049565008461	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
1049565008462	active site
1049565008463	catalytic residues [active]
1049565008464	metal binding site [ion binding]; metal-binding site
1049565008465	DmpG-like communication domain; Region: DmpG_comm; pfam07836
1049565008466	acetaldehyde dehydrogenase; Validated; Region: PRK08300
1049565008467	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1049565008468	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
1049565008469	2-keto-4-pentenoate hydratase; Provisional; Region: mhpD; PRK11342
1049565008470	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
1049565008471	Sugar fermentation stimulation protein; Region: SfsA; cl00647
1049565008472	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1049565008473	Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365
1049565008474	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
1049565008475	putative active site [active]
1049565008476	Fe(II) binding site [ion binding]; other site
1049565008477	putative dimer interface [polypeptide binding]; other site
1049565008478	putative tetramer interface [polypeptide binding]; other site
1049565008479	3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183
1049565008480	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1049565008481	DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834
1049565008482	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1049565008483	Bacterial transcriptional regulator; Region: IclR; pfam01614
1049565008484	Periplasmic binding protein TroA_e.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142
1049565008485	putative ligand binding residues [chemical binding]; other site
1049565008486	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1049565008487	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1049565008488	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1049565008489	ABC-ATPase subunit  interface; other site
1049565008490	dimer interface [polypeptide binding]; other site
1049565008491	putative PBP binding regions; other site
1049565008492	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1049565008493	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1049565008494	Walker A/P-loop; other site
1049565008495	ATP binding site [chemical binding]; other site
1049565008496	Q-loop/lid; other site
1049565008497	ABC transporter signature motif; other site
1049565008498	Walker B; other site
1049565008499	D-loop; other site
1049565008500	H-loop/switch region; other site
1049565008501	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1049565008502	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1049565008503	shikimate 5-dehydrogenase; Provisional; Region: PRK12548
1049565008504	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1049565008505	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1049565008506	shikimate binding site; other site
1049565008507	NAD(P) binding site [chemical binding]; other site
1049565008508	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565008509	D-galactonate transporter; Region: 2A0114; TIGR00893
1049565008510	putative substrate translocation pore; other site
1049565008511	potential frameshift: common BLAST hit: gi|238895179|ref|YP_002919914.1| putative 4-hydroxyphenylpyruvate dioxygenase
1049565008512	HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008
1049565008513	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1049565008514	Protein of unknown function (DUF2767); Region: DUF2767; pfam10965
1049565008515	pyruvate kinase; Provisional; Region: PRK09206
1049565008516	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288
1049565008517	domain interfaces; other site
1049565008518	active site
1049565008519	murein lipoprotein; Provisional; Region: PRK15396
1049565008520	L,D-transpeptidase; Provisional; Region: PRK10260
1049565008521	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1049565008522	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1049565008523	cysteine desufuration protein SufE; Provisional; Region: PRK09296
1049565008524	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1049565008525	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1049565008526	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1049565008527	catalytic residue [active]
1049565008528	cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948
1049565008529	FeS assembly protein SufD; Region: sufD; TIGR01981
1049565008530	cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580
1049565008531	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
1049565008532	Walker A/P-loop; other site
1049565008533	ATP binding site [chemical binding]; other site
1049565008534	Q-loop/lid; other site
1049565008535	ABC transporter signature motif; other site
1049565008536	Walker B; other site
1049565008537	D-loop; other site
1049565008538	H-loop/switch region; other site
1049565008539	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
1049565008540	putative ABC transporter; Region: ycf24; CHL00085
1049565008541	iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504
1049565008542	DoxX; Region: DoxX; pfam07681
1049565008543	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1049565008544	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1049565008545	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
1049565008546	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
1049565008547	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1049565008548	phosphate binding site [ion binding]; other site
1049565008549	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1049565008550	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1049565008551	HlyD family secretion protein; Region: HlyD_3; pfam13437
1049565008552	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1049565008553	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1049565008554	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1049565008555	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1049565008556	NAD(P) binding site [chemical binding]; other site
1049565008557	active site
1049565008558	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565008559	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565008560	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1049565008561	dimerization interface [polypeptide binding]; other site
1049565008562	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1049565008563	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
1049565008564	intersubunit interface [polypeptide binding]; other site
1049565008565	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1049565008566	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1049565008567	ABC-ATPase subunit  interface; other site
1049565008568	dimer interface [polypeptide binding]; other site
1049565008569	putative PBP binding regions; other site
1049565008570	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1049565008571	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1049565008572	Walker A/P-loop; other site
1049565008573	ATP binding site [chemical binding]; other site
1049565008574	Q-loop/lid; other site
1049565008575	ABC transporter signature motif; other site
1049565008576	Walker B; other site
1049565008577	D-loop; other site
1049565008578	H-loop/switch region; other site
1049565008579	multidrug resistance protein MdtH; Provisional; Region: PRK11646
1049565008580	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565008581	methionine synthase; Provisional; Region: PRK01207
1049565008582	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1049565008583	substrate binding site [chemical binding]; other site
1049565008584	THF binding site; other site
1049565008585	zinc-binding site [ion binding]; other site
1049565008586	Domain of unknown function (DUF1852); Region: DUF1852; pfam08908
1049565008587	hypothetical protein; Provisional; Region: PRK10457
1049565008588	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1049565008589	CoenzymeA binding site [chemical binding]; other site
1049565008590	subunit interaction site [polypeptide binding]; other site
1049565008591	PHB binding site; other site
1049565008592	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1049565008593	FAD binding domain; Region: FAD_binding_4; pfam01565
1049565008594	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1049565008595	putative inner membrane protein; Provisional; Region: PRK10983
1049565008596	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1049565008597	phosphoenolpyruvate synthase; Validated; Region: PRK06464
1049565008598	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
1049565008599	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1049565008600	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1049565008601	PEP synthetase regulatory protein; Provisional; Region: PRK05339
1049565008602	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756
1049565008603	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1049565008604	hypothetical protein; Provisional; Region: PRK10183
1049565008605	Uncharacterized conserved protein [Function unknown]; Region: COG0397
1049565008606	hypothetical protein; Validated; Region: PRK00029
1049565008607	Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405
1049565008608	NlpC/P60 family; Region: NLPC_P60; pfam00877
1049565008609	vitamin B12-transporter ATPase; Provisional; Region: PRK03695
1049565008610	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1049565008611	Walker A/P-loop; other site
1049565008612	ATP binding site [chemical binding]; other site
1049565008613	Q-loop/lid; other site
1049565008614	ABC transporter signature motif; other site
1049565008615	Walker B; other site
1049565008616	D-loop; other site
1049565008617	H-loop/switch region; other site
1049565008618	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1049565008619	catalytic residues [active]
1049565008620	dimer interface [polypeptide binding]; other site
1049565008621	DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063
1049565008622	NLPA lipoprotein; Region: Lipoprotein_9; cl17547
1049565008623	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1049565008624	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1049565008625	ABC-ATPase subunit  interface; other site
1049565008626	dimer interface [polypeptide binding]; other site
1049565008627	putative PBP binding regions; other site
1049565008628	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565008629	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565008630	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1049565008631	dimerization interface [polypeptide binding]; other site
1049565008632	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
1049565008633	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1049565008634	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
1049565008635	homotrimer interaction site [polypeptide binding]; other site
1049565008636	putative active site [active]
1049565008637	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1049565008638	IHF dimer interface [polypeptide binding]; other site
1049565008639	IHF - DNA interface [nucleotide binding]; other site
1049565008640	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1049565008641	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1049565008642	putative tRNA-binding site [nucleotide binding]; other site
1049565008643	B3/4 domain; Region: B3_4; pfam03483
1049565008644	tRNA synthetase B5 domain; Region: B5; smart00874
1049565008645	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1049565008646	dimer interface [polypeptide binding]; other site
1049565008647	motif 1; other site
1049565008648	motif 3; other site
1049565008649	motif 2; other site
1049565008650	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
1049565008651	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1049565008652	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1049565008653	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1049565008654	dimer interface [polypeptide binding]; other site
1049565008655	motif 1; other site
1049565008656	active site
1049565008657	motif 2; other site
1049565008658	motif 3; other site
1049565008659	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1049565008660	23S rRNA binding site [nucleotide binding]; other site
1049565008661	L21 binding site [polypeptide binding]; other site
1049565008662	L13 binding site [polypeptide binding]; other site
1049565008663	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
1049565008664	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
1049565008665	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1049565008666	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1049565008667	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
1049565008668	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
1049565008669	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
1049565008670	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1049565008671	active site
1049565008672	dimer interface [polypeptide binding]; other site
1049565008673	motif 1; other site
1049565008674	motif 2; other site
1049565008675	motif 3; other site
1049565008676	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1049565008677	anticodon binding site; other site
1049565008678	Protein of unknown function (DUF1471); Region: DUF1471; cl11507
1049565008679	Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137
1049565008680	6-phosphofructokinase 2; Provisional; Region: PRK10294
1049565008681	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1049565008682	putative substrate binding site [chemical binding]; other site
1049565008683	putative ATP binding site [chemical binding]; other site
1049565008684	Protein of unknown function (DUF2622); Region: DUF2622; pfam11080
1049565008685	Phosphotransferase enzyme family; Region: APH; pfam01636
1049565008686	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1049565008687	active site
1049565008688	ATP binding site [chemical binding]; other site
1049565008689	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1049565008690	active site
1049565008691	ATP binding site [chemical binding]; other site
1049565008692	transport protein TonB; Provisional; Region: PRK10819
1049565008693	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
1049565008694	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1049565008695	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
1049565008696	catalytic residues [active]
1049565008697	catalytic nucleophile [active]
1049565008698	Recombinase; Region: Recombinase; pfam07508
1049565008699	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
1049565008700	Bacterial PH domain; Region: DUF304; pfam03703
1049565008701	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1049565008702	Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767
1049565008703	catalytic residues [active]
1049565008704	catalytic nucleophile [active]
1049565008705	Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394
1049565008706	YciI-like protein; Reviewed; Region: PRK11370
1049565008707	Uncharacterized conserved protein [Function unknown]; Region: COG2353
1049565008708	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
1049565008709	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
1049565008710	Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152
1049565008711	putative active site [active]
1049565008712	catalytic site [active]
1049565008713	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158
1049565008714	putative active site [active]
1049565008715	catalytic site [active]
1049565008716	dsDNA-mimic protein; Reviewed; Region: PRK05094
1049565008717	Ion transport protein; Region: Ion_trans; pfam00520
1049565008718	Ion channel; Region: Ion_trans_2; pfam07885
1049565008719	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
1049565008720	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1049565008721	Walker A/P-loop; other site
1049565008722	ATP binding site [chemical binding]; other site
1049565008723	Q-loop/lid; other site
1049565008724	ABC transporter signature motif; other site
1049565008725	Walker B; other site
1049565008726	D-loop; other site
1049565008727	H-loop/switch region; other site
1049565008728	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1049565008729	oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473
1049565008730	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1049565008731	Walker A/P-loop; other site
1049565008732	ATP binding site [chemical binding]; other site
1049565008733	Q-loop/lid; other site
1049565008734	ABC transporter signature motif; other site
1049565008735	Walker B; other site
1049565008736	D-loop; other site
1049565008737	H-loop/switch region; other site
1049565008738	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1049565008739	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
1049565008740	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1049565008741	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565008742	dimer interface [polypeptide binding]; other site
1049565008743	conserved gate region; other site
1049565008744	ABC-ATPase subunit interface; other site
1049565008745	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
1049565008746	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565008747	dimer interface [polypeptide binding]; other site
1049565008748	conserved gate region; other site
1049565008749	putative PBP binding loops; other site
1049565008750	ABC-ATPase subunit interface; other site
1049565008751	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
1049565008752	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1049565008753	peptide binding site [polypeptide binding]; other site
1049565008754	hypothetical protein; Provisional; Region: PRK11111
1049565008755	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
1049565008756	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
1049565008757	putative catalytic cysteine [active]
1049565008758	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
1049565008759	putative active site [active]
1049565008760	metal binding site [ion binding]; metal-binding site
1049565008761	thymidine kinase; Provisional; Region: PRK04296
1049565008762	global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947
1049565008763	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
1049565008764	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1049565008765	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1049565008766	active site
1049565008767	tetramer interface; other site
1049565008768	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1049565008769	active site
1049565008770	response regulator of RpoS; Provisional; Region: PRK10693
1049565008771	phosphorylation site [posttranslational modification]
1049565008772	intermolecular recognition site; other site
1049565008773	dimerization interface [polypeptide binding]; other site
1049565008774	hypothetical protein; Provisional; Region: PRK10279
1049565008775	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
1049565008776	nucleophile elbow; other site
1049565008777	hypothetical protein; Provisional; Region: PRK01617
1049565008778	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
1049565008779	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
1049565008780	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
1049565008781	putative active site [active]
1049565008782	putative substrate binding site [chemical binding]; other site
1049565008783	putative cosubstrate binding site; other site
1049565008784	catalytic site [active]
1049565008785	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1049565008786	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
1049565008787	AsnC family; Region: AsnC_trans_reg; pfam01037
1049565008788	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1049565008789	EamA-like transporter family; Region: EamA; pfam00892
1049565008790	EamA-like transporter family; Region: EamA; pfam00892
1049565008791	respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351
1049565008792	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
1049565008793	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
1049565008794	4Fe-4S binding domain; Region: Fer4; cl02805
1049565008795	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
1049565008796	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
1049565008797	[4Fe-4S] binding site [ion binding]; other site
1049565008798	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1049565008799	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1049565008800	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1049565008801	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
1049565008802	molybdopterin cofactor binding site; other site
1049565008803	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
1049565008804	nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600
1049565008805	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
1049565008806	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1049565008807	dimerization interface [polypeptide binding]; other site
1049565008808	Histidine kinase; Region: HisKA_3; pfam07730
1049565008809	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1049565008810	ATP binding site [chemical binding]; other site
1049565008811	Mg2+ binding site [ion binding]; other site
1049565008812	G-X-G motif; other site
1049565008813	transcriptional regulator NarL; Provisional; Region: PRK10651
1049565008814	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1049565008815	active site
1049565008816	phosphorylation site [posttranslational modification]
1049565008817	intermolecular recognition site; other site
1049565008818	dimerization interface [polypeptide binding]; other site
1049565008819	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1049565008820	DNA binding residues [nucleotide binding]
1049565008821	dimerization interface [polypeptide binding]; other site
1049565008822	putative invasin; Provisional; Region: PRK10177
1049565008823	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
1049565008824	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
1049565008825	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
1049565008826	[4Fe-4S] binding site [ion binding]; other site
1049565008827	molybdopterin cofactor binding site; other site
1049565008828	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
1049565008829	molybdopterin cofactor binding site; other site
1049565008830	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1049565008831	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1049565008832	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1049565008833	nitrite reductase subunit NirD; Provisional; Region: PRK14989
1049565008834	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1049565008835	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1049565008836	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1049565008837	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
1049565008838	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1049565008839	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1049565008840	Walker A/P-loop; other site
1049565008841	ATP binding site [chemical binding]; other site
1049565008842	Q-loop/lid; other site
1049565008843	ABC transporter signature motif; other site
1049565008844	Walker B; other site
1049565008845	D-loop; other site
1049565008846	H-loop/switch region; other site
1049565008847	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1049565008848	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565008849	dimer interface [polypeptide binding]; other site
1049565008850	conserved gate region; other site
1049565008851	putative PBP binding loops; other site
1049565008852	ABC-ATPase subunit interface; other site
1049565008853	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1049565008854	NMT1-like family; Region: NMT1_2; pfam13379
1049565008855	Nitrate and nitrite sensing; Region: NIT; pfam08376
1049565008856	ANTAR domain; Region: ANTAR; pfam03861
1049565008857	Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553
1049565008858	Domain of unknown function (DUF1883); Region: DUF1883; pfam08980
1049565008859	Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703
1049565008860	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
1049565008861	putative active site pocket [active]
1049565008862	dimerization interface [polypeptide binding]; other site
1049565008863	putative catalytic residue [active]
1049565008864	cation transport regulator; Reviewed; Region: chaB; PRK09582
1049565008865	calcium/sodium:proton antiporter; Provisional; Region: PRK10599
1049565008866	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1049565008867	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
1049565008868	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1049565008869	hypothetical protein; Provisional; Region: PRK10941
1049565008870	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
1049565008871	hypothetical protein; Provisional; Region: PRK10278
1049565008872	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1049565008873	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1049565008874	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1049565008875	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1049565008876	RF-1 domain; Region: RF-1; pfam00472
1049565008877	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
1049565008878	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
1049565008879	tRNA; other site
1049565008880	putative tRNA binding site [nucleotide binding]; other site
1049565008881	putative NADP binding site [chemical binding]; other site
1049565008882	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
1049565008883	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
1049565008884	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
1049565008885	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
1049565008886	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1049565008887	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1049565008888	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
1049565008889	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1049565008890	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1049565008891	active site
1049565008892	putative transporter; Provisional; Region: PRK11660
1049565008893	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1049565008894	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1049565008895	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1049565008896	Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788
1049565008897	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1049565008898	DNA binding residues [nucleotide binding]
1049565008899	putative dimer interface [polypeptide binding]; other site
1049565008900	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
1049565008901	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
1049565008902	hypothetical protein; Provisional; Region: PRK10692
1049565008903	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1049565008904	putative active site [active]
1049565008905	catalytic residue [active]
1049565008906	GTP-binding protein YchF; Reviewed; Region: PRK09601
1049565008907	YchF GTPase; Region: YchF; cd01900
1049565008908	G1 box; other site
1049565008909	GTP/Mg2+ binding site [chemical binding]; other site
1049565008910	Switch I region; other site
1049565008911	G2 box; other site
1049565008912	Switch II region; other site
1049565008913	G3 box; other site
1049565008914	G4 box; other site
1049565008915	G5 box; other site
1049565008916	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1049565008917	Domain of unknown function (DUF1869); Region: DUF1869; pfam08956
1049565008918	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
1049565008919	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1049565008920	putative ligand binding site [chemical binding]; other site
1049565008921	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
1049565008922	ImpA domain protein; Region: DUF3702; pfam12486
1049565008923	type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357
1049565008924	Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790
1049565008925	Protein of unknown function (DUF1305); Region: DUF1305; pfam06996
1049565008926	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
1049565008927	Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947
1049565008928	Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and    vesicular transport]; Region: IcmF; COG3523
1049565008929	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
1049565008930	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
1049565008931	PAAR motif; Region: PAAR_motif; pfam05488
1049565008932	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1049565008933	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1049565008934	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1049565008935	catalytic residue [active]
1049565008936	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1049565008937	Peptidase family M23; Region: Peptidase_M23; pfam01551
1049565008938	Rhs element Vgr protein; Region: vgr_GE; TIGR01646
1049565008939	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
1049565008940	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
1049565008941	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
1049565008942	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
1049565008943	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1049565008944	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1049565008945	ligand binding site [chemical binding]; other site
1049565008946	type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349
1049565008947	type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353
1049565008948	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
1049565008949	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
1049565008950	putative active site pocket [active]
1049565008951	dimerization interface [polypeptide binding]; other site
1049565008952	putative catalytic residue [active]
1049565008953	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122
1049565008954	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1049565008955	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1049565008956	active site
1049565008957	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1049565008958	DNA-binding site [nucleotide binding]; DNA binding site
1049565008959	RNA-binding motif; other site
1049565008960	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565008961	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565008962	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
1049565008963	putative dimerization interface [polypeptide binding]; other site
1049565008964	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1049565008965	citrate-proton symporter; Provisional; Region: PRK15075
1049565008966	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565008967	putative substrate translocation pore; other site
1049565008968	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
1049565008969	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565008970	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1049565008971	dimerization interface [polypeptide binding]; other site
1049565008972	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1049565008973	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1049565008974	Coenzyme A binding pocket [chemical binding]; other site
1049565008975	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
1049565008976	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
1049565008977	active site
1049565008978	substrate-binding site [chemical binding]; other site
1049565008979	metal-binding site [ion binding]
1049565008980	ATP binding site [chemical binding]; other site
1049565008981	cell density-dependent motility repressor; Provisional; Region: PRK10082
1049565008982	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565008983	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1049565008984	dimerization interface [polypeptide binding]; other site
1049565008985	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1049565008986	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1049565008987	Walker A/P-loop; other site
1049565008988	ATP binding site [chemical binding]; other site
1049565008989	Q-loop/lid; other site
1049565008990	ABC transporter signature motif; other site
1049565008991	Walker B; other site
1049565008992	D-loop; other site
1049565008993	H-loop/switch region; other site
1049565008994	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
1049565008995	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1049565008996	Walker A/P-loop; other site
1049565008997	ATP binding site [chemical binding]; other site
1049565008998	Q-loop/lid; other site
1049565008999	ABC transporter signature motif; other site
1049565009000	Walker B; other site
1049565009001	D-loop; other site
1049565009002	H-loop/switch region; other site
1049565009003	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
1049565009004	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
1049565009005	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1049565009006	TM-ABC transporter signature motif; other site
1049565009007	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1049565009008	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1049565009009	TM-ABC transporter signature motif; other site
1049565009010	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1049565009011	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
1049565009012	dimerization interface [polypeptide binding]; other site
1049565009013	ligand binding site [chemical binding]; other site
1049565009014	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
1049565009015	Pyruvate formate lyase 1; Region: PFL1; cd01678
1049565009016	coenzyme A binding site [chemical binding]; other site
1049565009017	active site
1049565009018	catalytic residues [active]
1049565009019	glycine loop; other site
1049565009020	propionate/acetate kinase; Provisional; Region: PRK12379
1049565009021	Acetate kinase [Energy production and conversion]; Region: ackA; COG0282
1049565009022	threonine/serine transporter TdcC; Provisional; Region: PRK13629
1049565009023	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
1049565009024	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
1049565009025	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1049565009026	tetramer interface [polypeptide binding]; other site
1049565009027	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565009028	catalytic residue [active]
1049565009029	DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341
1049565009030	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565009031	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1049565009032	dimerization interface [polypeptide binding]; other site
1049565009033	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1049565009034	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
1049565009035	Fatty acid desaturase protein family subgroup, a delta-12 acyl-lipid desaturase-like, DesA-like, yet uncharacterized subgroup of membrane fatty acid desaturase proteins found in alpha-, beta-, and gamma-proteobacteria. Sequences of this domain family...; Region: DesA_FADS-like; cd03509
1049565009036	Fatty acid desaturase; Region: FA_desaturase; pfam00487
1049565009037	putative di-iron ligands [ion binding]; other site
1049565009038	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1049565009039	Helix-turn-helix domain; Region: HTH_28; pfam13518
1049565009040	Helix-turn-helix domain; Region: HTH_28; pfam13518
1049565009041	Integrase core domain; Region: rve; pfam00665
1049565009042	Integrase core domain; Region: rve_2; pfam13333
1049565009043	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
1049565009044	Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765
1049565009045	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1049565009046	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
1049565009047	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1049565009048	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
1049565009049	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
1049565009050	Uncharacterized conserved protein [Function unknown]; Region: COG2308
1049565009051	trehalase; Provisional; Region: treA; PRK13271
1049565009052	Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626
1049565009053	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
1049565009054	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1049565009055	N-terminal plug; other site
1049565009056	ligand-binding site [chemical binding]; other site
1049565009057	lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470
1049565009058	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1049565009059	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1049565009060	catalytic residue [active]
1049565009061	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
1049565009062	dimer interface [polypeptide binding]; other site
1049565009063	catalytic triad [active]
1049565009064	NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263
1049565009065	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
1049565009066	TrkA-C domain; Region: TrkA_C; pfam02080
1049565009067	Transporter associated domain; Region: CorC_HlyC; smart01091
1049565009068	alanine racemase; Reviewed; Region: dadX; PRK03646
1049565009069	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
1049565009070	active site
1049565009071	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1049565009072	substrate binding site [chemical binding]; other site
1049565009073	catalytic residues [active]
1049565009074	dimer interface [polypeptide binding]; other site
1049565009075	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
1049565009076	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1049565009077	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1049565009078	SpoVR family protein; Provisional; Region: PRK11767
1049565009079	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
1049565009080	fatty acid metabolism regulator; Provisional; Region: PRK04984
1049565009081	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1049565009082	DNA-binding site [nucleotide binding]; DNA binding site
1049565009083	FadR C-terminal domain; Region: FadR_C; pfam07840
1049565009084	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
1049565009085	transmembrane helices; other site
1049565009086	disulfide bond formation protein B; Provisional; Region: PRK01749
1049565009087	Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615
1049565009088	hypothetical protein; Provisional; Region: PRK05170
1049565009089	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1049565009090	hypothetical protein; Provisional; Region: PRK10691
1049565009091	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100
1049565009092	septum formation inhibitor; Reviewed; Region: minC; PRK03511
1049565009093	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
1049565009094	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
1049565009095	cell division inhibitor MinD; Provisional; Region: PRK10818
1049565009096	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
1049565009097	Switch I; other site
1049565009098	Switch II; other site
1049565009099	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
1049565009100	ribonuclease D; Provisional; Region: PRK10829
1049565009101	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
1049565009102	catalytic site [active]
1049565009103	putative active site [active]
1049565009104	putative substrate binding site [chemical binding]; other site
1049565009105	Helicase and RNase D C-terminal; Region: HRDC; smart00341
1049565009106	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
1049565009107	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1049565009108	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
1049565009109	acyl-activating enzyme (AAE) consensus motif; other site
1049565009110	putative AMP binding site [chemical binding]; other site
1049565009111	putative active site [active]
1049565009112	putative CoA binding site [chemical binding]; other site
1049565009113	Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065
1049565009114	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1049565009115	Glycoprotease family; Region: Peptidase_M22; pfam00814
1049565009116	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
1049565009117	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1049565009118	DEAD_2; Region: DEAD_2; pfam06733
1049565009119	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1049565009120	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
1049565009121	homotrimer interaction site [polypeptide binding]; other site
1049565009122	putative active site [active]
1049565009123	hypothetical protein; Provisional; Region: PRK05114
1049565009124	aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465
1049565009125	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1049565009126	aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553
1049565009127	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
1049565009128	putative active site [active]
1049565009129	putative CoA binding site [chemical binding]; other site
1049565009130	nudix motif; other site
1049565009131	metal binding site [ion binding]; metal-binding site
1049565009132	L-serine deaminase; Provisional; Region: PRK15023
1049565009133	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1049565009134	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
1049565009135	phage resistance protein; Provisional; Region: PRK10551
1049565009136	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
1049565009137	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1049565009138	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
1049565009139	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1049565009140	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1049565009141	Transporter associated domain; Region: CorC_HlyC; smart01091
1049565009142	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
1049565009143	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1049565009144	active pocket/dimerization site; other site
1049565009145	active site
1049565009146	phosphorylation site [posttranslational modification]
1049565009147	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
1049565009148	active site
1049565009149	phosphorylation site [posttranslational modification]
1049565009150	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
1049565009151	PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103
1049565009152	hypothetical protein; Provisional; Region: PRK02913
1049565009153	hypothetical protein; Provisional; Region: PRK11469
1049565009154	Domain of unknown function DUF; Region: DUF204; pfam02659
1049565009155	Domain of unknown function DUF; Region: DUF204; pfam02659
1049565009156	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
1049565009157	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1049565009158	S-adenosylmethionine binding site [chemical binding]; other site
1049565009159	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
1049565009160	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1049565009161	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1049565009162	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1049565009163	DNA-binding site [nucleotide binding]; DNA binding site
1049565009164	RNA-binding motif; other site
1049565009165	YebO-like protein; Region: YebO; pfam13974
1049565009166	PhoPQ regulatory protein; Provisional; Region: PRK10299
1049565009167	YobH-like protein; Region: YobH; pfam13996
1049565009168	DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090
1049565009169	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1049565009170	dimerization interface [polypeptide binding]; other site
1049565009171	putative Zn2+ binding site [ion binding]; other site
1049565009172	putative DNA binding site [nucleotide binding]; other site
1049565009173	Bacterial transcriptional regulator; Region: IclR; pfam01614
1049565009174	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565009175	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1049565009176	putative substrate translocation pore; other site
1049565009177	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565009178	heat shock protein HtpX; Provisional; Region: PRK05457
1049565009179	carboxy-terminal protease; Provisional; Region: PRK11186
1049565009180	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1049565009181	protein binding site [polypeptide binding]; other site
1049565009182	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1049565009183	Catalytic dyad [active]
1049565009184	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
1049565009185	ProP expression regulator; Provisional; Region: PRK04950
1049565009186	ProQ/FINO family; Region: ProQ; pfam04352
1049565009187	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
1049565009188	GAF domain; Region: GAF_2; pfam13185
1049565009189	Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995
1049565009190	Paraquat-inducible protein A; Region: PqiA; pfam04403
1049565009191	Paraquat-inducible protein A; Region: PqiA; pfam04403
1049565009192	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
1049565009193	mce related protein; Region: MCE; pfam02470
1049565009194	mce related protein; Region: MCE; pfam02470
1049565009195	mce related protein; Region: MCE; pfam02470
1049565009196	mce related protein; Region: MCE; pfam02470
1049565009197	mce related protein; Region: MCE; pfam02470
1049565009198	mce related protein; Region: MCE; pfam02470
1049565009199	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
1049565009200	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1049565009201	S-adenosylmethionine binding site [chemical binding]; other site
1049565009202	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
1049565009203	Protein of unknown function (DUF1480); Region: DUF1480; pfam07351
1049565009204	Protein of unknown function (DUF1482); Region: DUF1482; pfam07358
1049565009205	serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439
1049565009206	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1049565009207	Protein of unknown function (DUF535); Region: DUF535; pfam04393
1049565009208	Protein of unknown function (DUF2511); Region: DUF2511; pfam10709
1049565009209	Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276
1049565009210	CopC domain; Region: CopC; cl01012
1049565009211	DNA polymerase III subunit theta; Reviewed; Region: PRK10969
1049565009212	exodeoxyribonuclease X; Provisional; Region: PRK07983
1049565009213	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1049565009214	active site
1049565009215	catalytic site [active]
1049565009216	substrate binding site [chemical binding]; other site
1049565009217	protease 2; Provisional; Region: PRK10115
1049565009218	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1049565009219	Protein of unknown function (DUF533); Region: DUF533; pfam04391
1049565009220	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
1049565009221	putative metal binding site [ion binding]; other site
1049565009222	YebG protein; Region: YebG; pfam07130
1049565009223	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
1049565009224	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1049565009225	ATP-grasp domain; Region: ATP-grasp; pfam02222
1049565009226	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
1049565009227	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
1049565009228	active site
1049565009229	intersubunit interface [polypeptide binding]; other site
1049565009230	catalytic residue [active]
1049565009231	phosphogluconate dehydratase; Validated; Region: PRK09054
1049565009232	6-phosphogluconate dehydratase; Region: edd; TIGR01196
1049565009233	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
1049565009234	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1049565009235	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1049565009236	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
1049565009237	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1049565009238	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1049565009239	putative active site [active]
1049565009240	pyruvate kinase; Provisional; Region: PRK05826
1049565009241	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1049565009242	domain interfaces; other site
1049565009243	active site
1049565009244	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
1049565009245	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1049565009246	putative acyl-acceptor binding pocket; other site
1049565009247	putative peptidase; Provisional; Region: PRK11649
1049565009248	Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525
1049565009249	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1049565009250	Peptidase family M23; Region: Peptidase_M23; pfam01551
1049565009251	high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545
1049565009252	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
1049565009253	metal binding site [ion binding]; metal-binding site
1049565009254	high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544
1049565009255	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1049565009256	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1049565009257	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1049565009258	ABC-ATPase subunit  interface; other site
1049565009259	dimer interface [polypeptide binding]; other site
1049565009260	putative PBP binding regions; other site
1049565009261	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1049565009262	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1049565009263	Walker A motif; other site
1049565009264	ATP binding site [chemical binding]; other site
1049565009265	Walker B motif; other site
1049565009266	arginine finger; other site
1049565009267	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1049565009268	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
1049565009269	RuvA N terminal domain; Region: RuvA_N; pfam01330
1049565009270	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
1049565009271	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
1049565009272	active site
1049565009273	putative DNA-binding cleft [nucleotide binding]; other site
1049565009274	dimer interface [polypeptide binding]; other site
1049565009275	hypothetical protein; Validated; Region: PRK00110
1049565009276	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
1049565009277	nudix motif; other site
1049565009278	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1049565009279	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1049565009280	dimer interface [polypeptide binding]; other site
1049565009281	anticodon binding site; other site
1049565009282	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1049565009283	homodimer interface [polypeptide binding]; other site
1049565009284	motif 1; other site
1049565009285	active site
1049565009286	motif 2; other site
1049565009287	GAD domain; Region: GAD; pfam02938
1049565009288	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1049565009289	active site
1049565009290	motif 3; other site
1049565009291	Isochorismatase family; Region: Isochorismatase; pfam00857
1049565009292	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1049565009293	catalytic triad [active]
1049565009294	conserved cis-peptide bond; other site
1049565009295	hypothetical protein; Provisional; Region: PRK10302
1049565009296	Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788
1049565009297	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1049565009298	S-adenosylmethionine binding site [chemical binding]; other site
1049565009299	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1049565009300	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1049565009301	S-adenosylmethionine binding site [chemical binding]; other site
1049565009302	copper homeostasis protein CutC; Provisional; Region: PRK11572
1049565009303	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268
1049565009304	putative metal binding site [ion binding]; other site
1049565009305	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
1049565009306	arginyl-tRNA synthetase; Region: argS; TIGR00456
1049565009307	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1049565009308	active site
1049565009309	HIGH motif; other site
1049565009310	KMSK motif region; other site
1049565009311	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
1049565009312	tRNA binding surface [nucleotide binding]; other site
1049565009313	anticodon binding site; other site
1049565009314	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
1049565009315	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
1049565009316	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565009317	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1049565009318	Ligand Binding Site [chemical binding]; other site
1049565009319	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
1049565009320	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
1049565009321	active site
1049565009322	homotetramer interface [polypeptide binding]; other site
1049565009323	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187
1049565009324	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
1049565009325	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1049565009326	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1049565009327	TM-ABC transporter signature motif; other site
1049565009328	L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288
1049565009329	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1049565009330	Walker A/P-loop; other site
1049565009331	ATP binding site [chemical binding]; other site
1049565009332	Q-loop/lid; other site
1049565009333	ABC transporter signature motif; other site
1049565009334	Walker B; other site
1049565009335	D-loop; other site
1049565009336	H-loop/switch region; other site
1049565009337	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1049565009338	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
1049565009339	Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540
1049565009340	ligand binding site [chemical binding]; other site
1049565009341	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
1049565009342	Ferritin-like domain; Region: Ferritin; pfam00210
1049565009343	ferroxidase diiron center [ion binding]; other site
1049565009344	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
1049565009345	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
1049565009346	Protein of unknown function (DUF2766); Region: DUF2766; pfam10964
1049565009347	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565009348	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1049565009349	putative substrate translocation pore; other site
1049565009350	hypothetical protein; Provisional; Region: PRK09273
1049565009351	Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698
1049565009352	Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408
1049565009353	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
1049565009354	Ferritin-like domain; Region: Ferritin; pfam00210
1049565009355	ferroxidase diiron center [ion binding]; other site
1049565009356	probable metal-binding protein; Region: matur_matur; TIGR03853
1049565009357	tyrosine transporter TyrP; Provisional; Region: PRK15132
1049565009358	aromatic amino acid transport protein; Region: araaP; TIGR00837
1049565009359	hypothetical protein; Provisional; Region: PRK10396
1049565009360	yecA family protein; Region: ygfB_yecA; TIGR02292
1049565009361	SEC-C motif; Region: SEC-C; pfam02810
1049565009362	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1049565009363	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1049565009364	active site
1049565009365	inhibitor site; inhibition site
1049565009366	dimer interface [polypeptide binding]; other site
1049565009367	catalytic residue [active]
1049565009368	phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832
1049565009369	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1049565009370	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1049565009371	GIY-YIG motif/motif A; other site
1049565009372	active site
1049565009373	catalytic site [active]
1049565009374	putative DNA binding site [nucleotide binding]; other site
1049565009375	metal binding site [ion binding]; metal-binding site
1049565009376	UvrB/uvrC motif; Region: UVR; pfam02151
1049565009377	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1049565009378	response regulator; Provisional; Region: PRK09483
1049565009379	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1049565009380	active site
1049565009381	phosphorylation site [posttranslational modification]
1049565009382	intermolecular recognition site; other site
1049565009383	dimerization interface [polypeptide binding]; other site
1049565009384	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1049565009385	DNA binding residues [nucleotide binding]
1049565009386	dimerization interface [polypeptide binding]; other site
1049565009387	hypothetical protein; Provisional; Region: PRK10613
1049565009388	DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188
1049565009389	Autoinducer binding domain; Region: Autoind_bind; pfam03472
1049565009390	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1049565009391	DNA binding residues [nucleotide binding]
1049565009392	dimerization interface [polypeptide binding]; other site
1049565009393	putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264
1049565009394	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1049565009395	Walker A/P-loop; other site
1049565009396	ATP binding site [chemical binding]; other site
1049565009397	Q-loop/lid; other site
1049565009398	ABC transporter signature motif; other site
1049565009399	Walker B; other site
1049565009400	D-loop; other site
1049565009401	H-loop/switch region; other site
1049565009402	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1049565009403	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565009404	dimer interface [polypeptide binding]; other site
1049565009405	conserved gate region; other site
1049565009406	putative PBP binding loops; other site
1049565009407	ABC-ATPase subunit interface; other site
1049565009408	D-cysteine desulfhydrase; Validated; Region: PRK03910
1049565009409	Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449
1049565009410	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565009411	catalytic residue [active]
1049565009412	cystine transporter subunit; Provisional; Region: PRK11260
1049565009413	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1049565009414	substrate binding pocket [chemical binding]; other site
1049565009415	membrane-bound complex binding site; other site
1049565009416	hinge residues; other site
1049565009417	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
1049565009418	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
1049565009419	active site
1049565009420	Na/Ca binding site [ion binding]; other site
1049565009421	catalytic site [active]
1049565009422	lipoprotein; Provisional; Region: PRK10397
1049565009423	colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411
1049565009424	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1049565009425	DNA binding residues [nucleotide binding]
1049565009426	dimerization interface [polypeptide binding]; other site
1049565009427	hypothetical protein; Provisional; Region: PRK10708
1049565009428	Protein of unknown function (DUF2525); Region: DUF2525; pfam10733
1049565009429	putative diguanylate cyclase YedQ; Provisional; Region: PRK15426
1049565009430	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1049565009431	metal binding site [ion binding]; metal-binding site
1049565009432	active site
1049565009433	I-site; other site
1049565009434	hypothetical protein; Provisional; Region: PRK10062
1049565009435	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
1049565009436	EamA-like transporter family; Region: EamA; pfam00892
1049565009437	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
1049565009438	additional DNA contacts [nucleotide binding]; other site
1049565009439	mismatch recognition site; other site
1049565009440	active site
1049565009441	zinc binding site [ion binding]; other site
1049565009442	DNA intercalation site [nucleotide binding]; other site
1049565009443	DNA cytosine methylase; Provisional; Region: PRK10458
1049565009444	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1049565009445	cofactor binding site; other site
1049565009446	DNA binding site [nucleotide binding]
1049565009447	substrate interaction site [chemical binding]; other site
1049565009448	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
1049565009449	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1049565009450	Zn2+ binding site [ion binding]; other site
1049565009451	Mg2+ binding site [ion binding]; other site
1049565009452	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1049565009453	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1049565009454	trimer interface [polypeptide binding]; other site
1049565009455	eyelet of channel; other site
1049565009456	DgsA anti-repressor MtfA; Provisional; Region: PRK15410
1049565009457	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565009458	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
1049565009459	putative effector binding pocket; other site
1049565009460	putative dimerization interface [polypeptide binding]; other site
1049565009461	L,D-transpeptidase; Provisional; Region: PRK10190
1049565009462	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1049565009463	transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679
1049565009464	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1049565009465	dimerization interface [polypeptide binding]; other site
1049565009466	nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233
1049565009467	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565009468	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
1049565009469	putative dimerization interface [polypeptide binding]; other site
1049565009470	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
1049565009471	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
1049565009472	Protein of unknown function (DUF3036); Region: DUF3036; pfam11234
1049565009473	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1049565009474	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1049565009475	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
1049565009476	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
1049565009477	NADP binding site [chemical binding]; other site
1049565009478	dimer interface [polypeptide binding]; other site
1049565009479	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1049565009480	signal transduction protein PmrD; Provisional; Region: PRK15450
1049565009481	AMP nucleosidase; Provisional; Region: PRK08292
1049565009482	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
1049565009483	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
1049565009484	MATE family multidrug exporter; Provisional; Region: PRK10189
1049565009485	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
1049565009486	integrase; Provisional; Region: PRK09692
1049565009487	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
1049565009488	active site
1049565009489	Int/Topo IB signature motif; other site
1049565009490	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1049565009491	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
1049565009492	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1049565009493	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1049565009494	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1049565009495	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1049565009496	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1049565009497	putative active site [active]
1049565009498	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
1049565009499	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
1049565009500	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1049565009501	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1049565009502	DNA binding site [nucleotide binding]
1049565009503	Predicted ATPase [General function prediction only]; Region: COG3903
1049565009504	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565009505	putative substrate translocation pore; other site
1049565009506	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1049565009507	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
1049565009508	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1049565009509	NAD(P) binding site [chemical binding]; other site
1049565009510	active site
1049565009511	Transposase; Region: HTH_Tnp_1; cl17663
1049565009512	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1049565009513	Integrase core domain; Region: rve; pfam00665
1049565009514	Integrase core domain; Region: rve_3; pfam13683
1049565009515	DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219
1049565009516	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565009517	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
1049565009518	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1049565009519	HlyD family secretion protein; Region: HlyD_3; pfam13437
1049565009520	Protein of unknown function (DUF1656); Region: DUF1656; cl11658
1049565009521	Fusaric acid resistance protein family; Region: FUSC; pfam04632
1049565009522	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1049565009523	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1049565009524	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1049565009525	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565009526	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1049565009527	HTH-like domain; Region: HTH_21; pfam13276
1049565009528	Integrase core domain; Region: rve; pfam00665
1049565009529	Integrase core domain; Region: rve_3; pfam13683
1049565009530	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1049565009531	active site
1049565009532	substrate binding site [chemical binding]; other site
1049565009533	ATP binding site [chemical binding]; other site
1049565009534	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1049565009535	GAF domain; Region: GAF; pfam01590
1049565009536	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1049565009537	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1049565009538	metal binding site [ion binding]; metal-binding site
1049565009539	active site
1049565009540	I-site; other site
1049565009541	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1049565009542	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1049565009543	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1049565009544	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565009545	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1049565009546	dimerization interface [polypeptide binding]; other site
1049565009547	substrate binding pocket [chemical binding]; other site
1049565009548	Domain of unknown function (DUF1869); Region: DUF1869; pfam08956
1049565009549	Domain of unknown function (DUF1971); Region: DUF1971; cl17717
1049565009550	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1049565009551	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1049565009552	metal binding site [ion binding]; metal-binding site
1049565009553	active site
1049565009554	I-site; other site
1049565009555	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1049565009556	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
1049565009557	shikimate transporter; Provisional; Region: PRK09952
1049565009558	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565009559	putative substrate translocation pore; other site
1049565009560	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1049565009561	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565009562	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565009563	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1049565009564	putative effector binding pocket; other site
1049565009565	dimerization interface [polypeptide binding]; other site
1049565009566	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
1049565009567	HPP family; Region: HPP; pfam04982
1049565009568	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
1049565009569	NAD binding site [chemical binding]; other site
1049565009570	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
1049565009571	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
1049565009572	putative dimer interface [polypeptide binding]; other site
1049565009573	active site pocket [active]
1049565009574	putative cataytic base [active]
1049565009575	cobalamin synthase; Reviewed; Region: cobS; PRK00235
1049565009576	hypothetical protein; Provisional; Region: PRK05423
1049565009577	Predicted membrane protein [Function unknown]; Region: COG1289
1049565009578	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1049565009579	DNA gyrase inhibitor; Provisional; Region: PRK10016
1049565009580	D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397
1049565009581	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1049565009582	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
1049565009583	exonuclease I; Provisional; Region: sbcB; PRK11779
1049565009584	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
1049565009585	active site
1049565009586	catalytic site [active]
1049565009587	substrate binding site [chemical binding]; other site
1049565009588	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
1049565009589	elongation factor G; Reviewed; Region: PRK00007
1049565009590	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1049565009591	G1 box; other site
1049565009592	putative GEF interaction site [polypeptide binding]; other site
1049565009593	GTP/Mg2+ binding site [chemical binding]; other site
1049565009594	Switch I region; other site
1049565009595	G2 box; other site
1049565009596	G3 box; other site
1049565009597	Switch II region; other site
1049565009598	G4 box; other site
1049565009599	G5 box; other site
1049565009600	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1049565009601	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1049565009602	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1049565009603	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1049565009604	dimerization interface [polypeptide binding]; other site
1049565009605	putative DNA binding site [nucleotide binding]; other site
1049565009606	putative Zn2+ binding site [ion binding]; other site
1049565009607	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1049565009608	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565009609	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1049565009610	dimerization interface [polypeptide binding]; other site
1049565009611	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1049565009612	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
1049565009613	putative NAD(P) binding site [chemical binding]; other site
1049565009614	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
1049565009615	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
1049565009616	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
1049565009617	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
1049565009618	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1049565009619	NAD binding site [chemical binding]; other site
1049565009620	dimerization interface [polypeptide binding]; other site
1049565009621	product binding site; other site
1049565009622	substrate binding site [chemical binding]; other site
1049565009623	zinc binding site [ion binding]; other site
1049565009624	catalytic residues [active]
1049565009625	histidinol-phosphate aminotransferase; Provisional; Region: PRK01688
1049565009626	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1049565009627	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565009628	homodimer interface [polypeptide binding]; other site
1049565009629	catalytic residue [active]
1049565009630	imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446
1049565009631	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1049565009632	active site
1049565009633	motif I; other site
1049565009634	motif II; other site
1049565009635	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
1049565009636	putative active site pocket [active]
1049565009637	4-fold oligomerization interface [polypeptide binding]; other site
1049565009638	metal binding residues [ion binding]; metal-binding site
1049565009639	3-fold/trimer interface [polypeptide binding]; other site
1049565009640	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170
1049565009641	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
1049565009642	putative active site [active]
1049565009643	oxyanion strand; other site
1049565009644	catalytic triad [active]
1049565009645	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
1049565009646	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
1049565009647	catalytic residues [active]
1049565009648	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
1049565009649	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1049565009650	substrate binding site [chemical binding]; other site
1049565009651	glutamase interaction surface [polypeptide binding]; other site
1049565009652	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
1049565009653	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
1049565009654	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
1049565009655	metal binding site [ion binding]; metal-binding site
1049565009656	Predicted membrane protein [Function unknown]; Region: COG2246
1049565009657	GtrA-like protein; Region: GtrA; pfam04138
1049565009658	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1049565009659	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1049565009660	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1049565009661	active site
1049565009662	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
1049565009663	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1049565009664	putative ADP-binding pocket [chemical binding]; other site
1049565009665	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1049565009666	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1049565009667	active site
1049565009668	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
1049565009669	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1049565009670	UDP-galactopyranose mutase; Region: GLF; pfam03275
1049565009671	Domain of unknown function (DUF4422); Region: DUF4422; pfam14393
1049565009672	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
1049565009673	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
1049565009674	Ligand binding site; other site
1049565009675	metal-binding site
1049565009676	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
1049565009677	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
1049565009678	Walker A/P-loop; other site
1049565009679	ATP binding site [chemical binding]; other site
1049565009680	Q-loop/lid; other site
1049565009681	ABC transporter signature motif; other site
1049565009682	Walker B; other site
1049565009683	D-loop; other site
1049565009684	H-loop/switch region; other site
1049565009685	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
1049565009686	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1049565009687	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1049565009688	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
1049565009689	putative NAD(P) binding site [chemical binding]; other site
1049565009690	active site
1049565009691	putative substrate binding site [chemical binding]; other site
1049565009692	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
1049565009693	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1049565009694	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1049565009695	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1049565009696	phosphomannomutase CpsG; Provisional; Region: PRK15414
1049565009697	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
1049565009698	active site
1049565009699	substrate binding site [chemical binding]; other site
1049565009700	metal binding site [ion binding]; metal-binding site
1049565009701	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
1049565009702	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
1049565009703	Substrate binding site; other site
1049565009704	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
1049565009705	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1049565009706	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
1049565009707	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
1049565009708	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1049565009709	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
1049565009710	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
1049565009711	colanic acid exporter; Provisional; Region: PRK10459
1049565009712	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
1049565009713	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1049565009714	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
1049565009715	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1049565009716	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1049565009717	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1049565009718	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1049565009719	tyrosine kinase; Provisional; Region: PRK11519
1049565009720	Chain length determinant protein; Region: Wzz; pfam02706
1049565009721	Chain length determinant protein; Region: Wzz; cl15801
1049565009722	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
1049565009723	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1049565009724	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1049565009725	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
1049565009726	active site
1049565009727	polysaccharide export protein Wza; Provisional; Region: PRK15078
1049565009728	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
1049565009729	SLBB domain; Region: SLBB; pfam10531
1049565009730	Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052
1049565009731	Acid phosphatase homologues; Region: acidPPc; smart00014
1049565009732	active site
1049565009733	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1049565009734	active site
1049565009735	tetramer interface; other site
1049565009736	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
1049565009737	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
1049565009738	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1049565009739	Transporter associated domain; Region: CorC_HlyC; smart01091
1049565009740	putative assembly protein; Provisional; Region: PRK10833
1049565009741	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1049565009742	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1049565009743	trimer interface [polypeptide binding]; other site
1049565009744	active site
1049565009745	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
1049565009746	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
1049565009747	ATP-binding site [chemical binding]; other site
1049565009748	Sugar specificity; other site
1049565009749	Pyrimidine base specificity; other site
1049565009750	3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308
1049565009751	AlkA N-terminal domain; Region: AlkA_N; pfam06029
1049565009752	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1049565009753	minor groove reading motif; other site
1049565009754	helix-hairpin-helix signature motif; other site
1049565009755	substrate binding pocket [chemical binding]; other site
1049565009756	active site
1049565009757	putative chaperone; Provisional; Region: PRK11678
1049565009758	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
1049565009759	nucleotide binding site [chemical binding]; other site
1049565009760	putative NEF/HSP70 interaction site [polypeptide binding]; other site
1049565009761	SBD interface [polypeptide binding]; other site
1049565009762	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
1049565009763	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
1049565009764	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1049565009765	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1049565009766	dimer interface [polypeptide binding]; other site
1049565009767	phosphorylation site [posttranslational modification]
1049565009768	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1049565009769	ATP binding site [chemical binding]; other site
1049565009770	Mg2+ binding site [ion binding]; other site
1049565009771	G-X-G motif; other site
1049565009772	transcriptional regulator PhoB; Provisional; Region: PRK10161
1049565009773	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1049565009774	active site
1049565009775	phosphorylation site [posttranslational modification]
1049565009776	intermolecular recognition site; other site
1049565009777	dimerization interface [polypeptide binding]; other site
1049565009778	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
1049565009779	DNA binding site [nucleotide binding]
1049565009780	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
1049565009781	DNA binding residues [nucleotide binding]
1049565009782	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1049565009783	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
1049565009784	multidrug efflux system subunit MdtA; Provisional; Region: PRK11556
1049565009785	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1049565009786	HlyD family secretion protein; Region: HlyD_3; pfam13437
1049565009787	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
1049565009788	Protein export membrane protein; Region: SecD_SecF; cl14618
1049565009789	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
1049565009790	putative transporter; Provisional; Region: PRK10504
1049565009791	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565009792	putative substrate translocation pore; other site
1049565009793	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565009794	signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549
1049565009795	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1049565009796	dimerization interface [polypeptide binding]; other site
1049565009797	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1049565009798	dimer interface [polypeptide binding]; other site
1049565009799	phosphorylation site [posttranslational modification]
1049565009800	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1049565009801	ATP binding site [chemical binding]; other site
1049565009802	Mg2+ binding site [ion binding]; other site
1049565009803	G-X-G motif; other site
1049565009804	DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710
1049565009805	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1049565009806	active site
1049565009807	phosphorylation site [posttranslational modification]
1049565009808	intermolecular recognition site; other site
1049565009809	dimerization interface [polypeptide binding]; other site
1049565009810	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1049565009811	DNA binding site [nucleotide binding]
1049565009812	putative protease; Provisional; Region: PRK15452
1049565009813	Peptidase family U32; Region: Peptidase_U32; pfam01136
1049565009814	lipid kinase; Reviewed; Region: PRK13054
1049565009815	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1049565009816	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1049565009817	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1049565009818	Walker A/P-loop; other site
1049565009819	ATP binding site [chemical binding]; other site
1049565009820	Q-loop/lid; other site
1049565009821	ABC transporter signature motif; other site
1049565009822	Walker B; other site
1049565009823	D-loop; other site
1049565009824	H-loop/switch region; other site
1049565009825	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1049565009826	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1049565009827	Walker A/P-loop; other site
1049565009828	ATP binding site [chemical binding]; other site
1049565009829	Q-loop/lid; other site
1049565009830	ABC transporter signature motif; other site
1049565009831	Walker B; other site
1049565009832	D-loop; other site
1049565009833	H-loop/switch region; other site
1049565009834	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1049565009835	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1049565009836	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1049565009837	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565009838	dimer interface [polypeptide binding]; other site
1049565009839	conserved gate region; other site
1049565009840	ABC-ATPase subunit interface; other site
1049565009841	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1049565009842	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565009843	dimer interface [polypeptide binding]; other site
1049565009844	conserved gate region; other site
1049565009845	putative PBP binding loops; other site
1049565009846	ABC-ATPase subunit interface; other site
1049565009847	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1049565009848	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
1049565009849	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1049565009850	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 4. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_4; cd03329
1049565009851	putative active site pocket [active]
1049565009852	metal binding site [ion binding]; metal-binding site
1049565009853	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
1049565009854	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1049565009855	motif II; other site
1049565009856	polyol permease family; Region: 2A0118; TIGR00897
1049565009857	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565009858	putative substrate translocation pore; other site
1049565009859	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
1049565009860	N- and C-terminal domain interface [polypeptide binding]; other site
1049565009861	D-xylulose kinase; Region: XylB; TIGR01312
1049565009862	active site
1049565009863	MgATP binding site [chemical binding]; other site
1049565009864	catalytic site [active]
1049565009865	metal binding site [ion binding]; metal-binding site
1049565009866	xylulose binding site [chemical binding]; other site
1049565009867	homodimer interface [polypeptide binding]; other site
1049565009868	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1049565009869	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
1049565009870	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1049565009871	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1049565009872	Homeodomain-like domain; Region: HTH_23; pfam13384
1049565009873	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1049565009874	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1049565009875	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1049565009876	DNA binding site [nucleotide binding]
1049565009877	domain linker motif; other site
1049565009878	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
1049565009879	dimerization interface [polypeptide binding]; other site
1049565009880	ligand binding site [chemical binding]; other site
1049565009881	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1049565009882	classical (c) SDRs; Region: SDR_c; cd05233
1049565009883	NAD(P) binding site [chemical binding]; other site
1049565009884	active site
1049565009885	Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782
1049565009886	FGGY-family pentulose kinase; Region: 5C_CHO_kinase; TIGR01315
1049565009887	N- and C-terminal domain interface [polypeptide binding]; other site
1049565009888	active site
1049565009889	MgATP binding site [chemical binding]; other site
1049565009890	catalytic site [active]
1049565009891	metal binding site [ion binding]; metal-binding site
1049565009892	carbohydrate binding site [chemical binding]; other site
1049565009893	putative homodimer interface [polypeptide binding]; other site
1049565009894	polyol permease family; Region: 2A0118; TIGR00897
1049565009895	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565009896	putative substrate translocation pore; other site
1049565009897	fructose-bisphosphate aldolase; Provisional; Region: PRK09250
1049565009898	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
1049565009899	putative active site; other site
1049565009900	catalytic residue [active]
1049565009901	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1049565009902	dimer interface [polypeptide binding]; other site
1049565009903	substrate binding site [chemical binding]; other site
1049565009904	ATP binding site [chemical binding]; other site
1049565009905	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
1049565009906	substrate binding site [chemical binding]; other site
1049565009907	multimerization interface [polypeptide binding]; other site
1049565009908	ATP binding site [chemical binding]; other site
1049565009909	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1049565009910	Ligand Binding Site [chemical binding]; other site
1049565009911	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565009912	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565009913	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1049565009914	dimerization interface [polypeptide binding]; other site
1049565009915	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
1049565009916	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1049565009917	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
1049565009918	active site
1049565009919	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
1049565009920	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1049565009921	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565009922	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565009923	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1049565009924	putative effector binding pocket; other site
1049565009925	dimerization interface [polypeptide binding]; other site
1049565009926	Domain of unknown function (DUF3315); Region: DUF3315; cl02275
1049565009927	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1049565009928	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1049565009929	Coenzyme A binding pocket [chemical binding]; other site
1049565009930	antiporter inner membrane protein; Provisional; Region: PRK11670
1049565009931	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
1049565009932	Walker A motif; other site
1049565009933	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
1049565009934	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1049565009935	active site
1049565009936	HIGH motif; other site
1049565009937	KMSKS motif; other site
1049565009938	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1049565009939	tRNA binding surface [nucleotide binding]; other site
1049565009940	anticodon binding site; other site
1049565009941	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
1049565009942	dimer interface [polypeptide binding]; other site
1049565009943	putative tRNA-binding site [nucleotide binding]; other site
1049565009944	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807
1049565009945	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
1049565009946	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
1049565009947	putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697
1049565009948	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1049565009949	active site
1049565009950	phosphorylation site [posttranslational modification]
1049565009951	intermolecular recognition site; other site
1049565009952	dimerization interface [polypeptide binding]; other site
1049565009953	LytTr DNA-binding domain; Region: LytTR; pfam04397
1049565009954	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
1049565009955	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1049565009956	GAF domain; Region: GAF; pfam01590
1049565009957	Histidine kinase; Region: His_kinase; pfam06580
1049565009958	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1049565009959	ATP binding site [chemical binding]; other site
1049565009960	Mg2+ binding site [ion binding]; other site
1049565009961	G-X-G motif; other site
1049565009962	hypothetical protein; Provisional; Region: PRK13681
1049565009963	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565009964	dimer interface [polypeptide binding]; other site
1049565009965	conserved gate region; other site
1049565009966	putative PBP binding loops; other site
1049565009967	ABC-ATPase subunit interface; other site
1049565009968	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
1049565009969	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
1049565009970	Walker A/P-loop; other site
1049565009971	ATP binding site [chemical binding]; other site
1049565009972	Q-loop/lid; other site
1049565009973	ABC transporter signature motif; other site
1049565009974	Walker B; other site
1049565009975	D-loop; other site
1049565009976	H-loop/switch region; other site
1049565009977	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
1049565009978	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565009979	conserved gate region; other site
1049565009980	ABC-ATPase subunit interface; other site
1049565009981	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1049565009982	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
1049565009983	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
1049565009984	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
1049565009985	D-lactate dehydrogenase; Provisional; Region: PRK11183
1049565009986	FAD binding domain; Region: FAD_binding_4; pfam01565
1049565009987	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
1049565009988	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1049565009989	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1049565009990	Coenzyme A binding pocket [chemical binding]; other site
1049565009991	D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669
1049565009992	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1049565009993	Protein of unknown function (DUF1282); Region: DUF1282; pfam06930
1049565009994	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1049565009995	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1049565009996	Outer membrane efflux protein; Region: OEP; pfam02321
1049565009997	Outer membrane efflux protein; Region: OEP; pfam02321
1049565009998	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
1049565009999	beta-galactosidase; Region: BGL; TIGR03356
1049565010000	PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824
1049565010001	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1049565010002	active site turn [active]
1049565010003	phosphorylation site [posttranslational modification]
1049565010004	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1049565010005	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
1049565010006	HPr interaction site; other site
1049565010007	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1049565010008	active site
1049565010009	phosphorylation site [posttranslational modification]
1049565010010	transcriptional antiterminator BglG; Provisional; Region: PRK09772
1049565010011	CAT RNA binding domain; Region: CAT_RBD; smart01061
1049565010012	PRD domain; Region: PRD; pfam00874
1049565010013	PRD domain; Region: PRD; pfam00874
1049565010014	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
1049565010015	tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550
1049565010016	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1049565010017	FMN binding site [chemical binding]; other site
1049565010018	active site
1049565010019	catalytic residues [active]
1049565010020	substrate binding site [chemical binding]; other site
1049565010021	hypothetical protein; Provisional; Region: PRK01821
1049565010022	hypothetical protein; Provisional; Region: PRK10711
1049565010023	cytidine deaminase; Provisional; Region: PRK09027
1049565010024	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
1049565010025	active site
1049565010026	catalytic motif [active]
1049565010027	Zn binding site [ion binding]; other site
1049565010028	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
1049565010029	active site
1049565010030	catalytic motif [active]
1049565010031	Zn binding site [ion binding]; other site
1049565010032	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1049565010033	putative active site [active]
1049565010034	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1049565010035	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1049565010036	TM-ABC transporter signature motif; other site
1049565010037	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1049565010038	galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982
1049565010039	Walker A/P-loop; other site
1049565010040	ATP binding site [chemical binding]; other site
1049565010041	Q-loop/lid; other site
1049565010042	ABC transporter signature motif; other site
1049565010043	Walker B; other site
1049565010044	D-loop; other site
1049565010045	H-loop/switch region; other site
1049565010046	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1049565010047	methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395
1049565010048	Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539
1049565010049	ligand binding site [chemical binding]; other site
1049565010050	calcium binding site [ion binding]; other site
1049565010051	DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401
1049565010052	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1049565010053	DNA binding site [nucleotide binding]
1049565010054	domain linker motif; other site
1049565010055	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
1049565010056	dimerization interface (closed form) [polypeptide binding]; other site
1049565010057	ligand binding site [chemical binding]; other site
1049565010058	Predicted membrane protein [Function unknown]; Region: COG2311
1049565010059	hypothetical protein; Provisional; Region: PRK10835
1049565010060	GTP cyclohydrolase I; Provisional; Region: PLN03044
1049565010061	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
1049565010062	active site
1049565010063	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
1049565010064	S-formylglutathione hydrolase; Region: PLN02442
1049565010065	catecholate siderophore receptor CirA; Provisional; Region: PRK10064
1049565010066	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1049565010067	N-terminal plug; other site
1049565010068	ligand-binding site [chemical binding]; other site
1049565010069	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1049565010070	Helix-turn-helix domain; Region: HTH_28; pfam13518
1049565010071	Helix-turn-helix domain; Region: HTH_28; pfam13518
1049565010072	putative transposase OrfB; Reviewed; Region: PHA02517
1049565010073	HTH-like domain; Region: HTH_21; pfam13276
1049565010074	Integrase core domain; Region: rve; pfam00665
1049565010075	Integrase core domain; Region: rve_2; pfam13333
1049565010076	lysine transporter; Provisional; Region: PRK10836
1049565010077	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
1049565010078	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565010079	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
1049565010080	putative dimerization interface [polypeptide binding]; other site
1049565010081	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
1049565010082	endonuclease IV; Provisional; Region: PRK01060
1049565010083	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
1049565010084	DNA interaction; other site
1049565010085	Metal-binding active site; metal-binding site
1049565010086	AP (apurinic/apyrimidinic) site pocket; other site
1049565010087	PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712
1049565010088	N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925
1049565010089	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1049565010090	active site
1049565010091	P-loop; other site
1049565010092	phosphorylation site [posttranslational modification]
1049565010093	PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427
1049565010094	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
1049565010095	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1049565010096	putative substrate binding site [chemical binding]; other site
1049565010097	putative ATP binding site [chemical binding]; other site
1049565010098	bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109
1049565010099	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1049565010100	active site
1049565010101	phosphorylation site [posttranslational modification]
1049565010102	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1049565010103	dimerization domain swap beta strand [polypeptide binding]; other site
1049565010104	regulatory protein interface [polypeptide binding]; other site
1049565010105	active site
1049565010106	regulatory phosphorylation site [posttranslational modification]; other site
1049565010107	sugar efflux transporter B; Provisional; Region: PRK15011
1049565010108	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565010109	putative substrate translocation pore; other site
1049565010110	GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440
1049565010111	GIY-YIG motif/motif A; other site
1049565010112	putative active site [active]
1049565010113	putative metal binding site [ion binding]; other site
1049565010114	Flagellin N-methylase; Region: FliB; pfam03692
1049565010115	elongation factor P; Provisional; Region: PRK04542
1049565010116	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1049565010117	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1049565010118	RNA binding site [nucleotide binding]; other site
1049565010119	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1049565010120	RNA binding site [nucleotide binding]; other site
1049565010121	mannonate dehydratase; Provisional; Region: PRK03906
1049565010122	mannonate dehydratase; Region: uxuA; TIGR00695
1049565010123	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
1049565010124	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1049565010125	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1049565010126	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1049565010127	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1049565010128	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1049565010129	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1049565010130	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
1049565010131	active site
1049565010132	outer membrane lipoprotein; Provisional; Region: spr; PRK10838
1049565010133	NlpC/P60 family; Region: NLPC_P60; pfam00877
1049565010134	phage resistance protein; Provisional; Region: PRK10551
1049565010135	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
1049565010136	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1049565010137	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1049565010138	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
1049565010139	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
1049565010140	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565010141	dimer interface [polypeptide binding]; other site
1049565010142	conserved gate region; other site
1049565010143	putative PBP binding loops; other site
1049565010144	ABC-ATPase subunit interface; other site
1049565010145	microcin C ABC transporter permease; Provisional; Region: PRK15021
1049565010146	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565010147	dimer interface [polypeptide binding]; other site
1049565010148	conserved gate region; other site
1049565010149	ABC-ATPase subunit interface; other site
1049565010150	microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134
1049565010151	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1049565010152	Walker A/P-loop; other site
1049565010153	ATP binding site [chemical binding]; other site
1049565010154	Q-loop/lid; other site
1049565010155	ABC transporter signature motif; other site
1049565010156	Walker B; other site
1049565010157	D-loop; other site
1049565010158	H-loop/switch region; other site
1049565010159	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1049565010160	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1049565010161	Walker A/P-loop; other site
1049565010162	ATP binding site [chemical binding]; other site
1049565010163	Q-loop/lid; other site
1049565010164	ABC transporter signature motif; other site
1049565010165	Walker B; other site
1049565010166	D-loop; other site
1049565010167	H-loop/switch region; other site
1049565010168	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1049565010169	hypothetical protein; Provisional; Region: PRK11835
1049565010170	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565010171	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
1049565010172	putative substrate translocation pore; other site
1049565010173	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
1049565010174	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1049565010175	RNA binding surface [nucleotide binding]; other site
1049565010176	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
1049565010177	active site
1049565010178	uracil binding [chemical binding]; other site
1049565010179	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1049565010180	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1049565010181	ATP binding site [chemical binding]; other site
1049565010182	putative Mg++ binding site [ion binding]; other site
1049565010183	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1049565010184	nucleotide binding region [chemical binding]; other site
1049565010185	ATP-binding site [chemical binding]; other site
1049565010186	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
1049565010187	5S rRNA interface [nucleotide binding]; other site
1049565010188	CTC domain interface [polypeptide binding]; other site
1049565010189	L16 interface [polypeptide binding]; other site
1049565010190	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565010191	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565010192	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1049565010193	dimerization interface [polypeptide binding]; other site
1049565010194	Beta-lactamase; Region: Beta-lactamase; pfam00144
1049565010195	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1049565010196	GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009
1049565010197	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1049565010198	dimer interface [polypeptide binding]; other site
1049565010199	ADP-ribose binding site [chemical binding]; other site
1049565010200	active site
1049565010201	nudix motif; other site
1049565010202	metal binding site [ion binding]; metal-binding site
1049565010203	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1049565010204	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1049565010205	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1049565010206	Nucleoid-associated protein [General function prediction only]; Region: COG3081
1049565010207	nucleoid-associated protein NdpA; Validated; Region: PRK00378
1049565010208	hypothetical protein; Provisional; Region: PRK13689
1049565010209	Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083
1049565010210	Domain of unknown function (DUF3413); Region: DUF3413; pfam11893
1049565010211	Sulfatase; Region: Sulfatase; cl17466
1049565010212	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1049565010213	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1049565010214	Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242
1049565010215	secondary substrate binding site; other site
1049565010216	primary substrate binding site; other site
1049565010217	inhibition loop; other site
1049565010218	dimerization interface [polypeptide binding]; other site
1049565010219	malate:quinone oxidoreductase; Validated; Region: PRK05257
1049565010220	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
1049565010221	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1049565010222	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1049565010223	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1049565010224	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
1049565010225	MgtE intracellular N domain; Region: MgtE_N; smart00924
1049565010226	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
1049565010227	Divalent cation transporter; Region: MgtE; cl00786
1049565010228	multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522
1049565010229	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1049565010230	Walker A/P-loop; other site
1049565010231	ATP binding site [chemical binding]; other site
1049565010232	Q-loop/lid; other site
1049565010233	ABC transporter signature motif; other site
1049565010234	Walker B; other site
1049565010235	D-loop; other site
1049565010236	H-loop/switch region; other site
1049565010237	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
1049565010238	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
1049565010239	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
1049565010240	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565010241	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565010242	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
1049565010243	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1049565010244	DNA binding site [nucleotide binding]
1049565010245	active site
1049565010246	thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461
1049565010247	ApbE family; Region: ApbE; pfam02424
1049565010248	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1049565010249	outer membrane porin protein C; Provisional; Region: PRK10554
1049565010250	phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618
1049565010251	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1049565010252	ATP binding site [chemical binding]; other site
1049565010253	Mg2+ binding site [ion binding]; other site
1049565010254	G-X-G motif; other site
1049565010255	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1049565010256	putative binding surface; other site
1049565010257	active site
1049565010258	transcriptional regulator RcsB; Provisional; Region: PRK10840
1049565010259	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1049565010260	active site
1049565010261	phosphorylation site [posttranslational modification]
1049565010262	intermolecular recognition site; other site
1049565010263	dimerization interface [polypeptide binding]; other site
1049565010264	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1049565010265	DNA binding residues [nucleotide binding]
1049565010266	dimerization interface [polypeptide binding]; other site
1049565010267	hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841
1049565010268	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1049565010269	dimer interface [polypeptide binding]; other site
1049565010270	phosphorylation site [posttranslational modification]
1049565010271	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1049565010272	ATP binding site [chemical binding]; other site
1049565010273	Mg2+ binding site [ion binding]; other site
1049565010274	G-X-G motif; other site
1049565010275	RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456
1049565010276	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1049565010277	active site
1049565010278	phosphorylation site [posttranslational modification]
1049565010279	intermolecular recognition site; other site
1049565010280	dimerization interface [polypeptide binding]; other site
1049565010281	sensory histidine kinase AtoS; Provisional; Region: PRK11360
1049565010282	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1049565010283	putative active site [active]
1049565010284	heme pocket [chemical binding]; other site
1049565010285	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1049565010286	dimer interface [polypeptide binding]; other site
1049565010287	phosphorylation site [posttranslational modification]
1049565010288	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1049565010289	ATP binding site [chemical binding]; other site
1049565010290	Mg2+ binding site [ion binding]; other site
1049565010291	G-X-G motif; other site
1049565010292	acetoacetate metabolism regulatory protein AtoC; Provisional; Region: PRK11361
1049565010293	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1049565010294	active site
1049565010295	phosphorylation site [posttranslational modification]
1049565010296	intermolecular recognition site; other site
1049565010297	dimerization interface [polypeptide binding]; other site
1049565010298	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1049565010299	Walker A motif; other site
1049565010300	ATP binding site [chemical binding]; other site
1049565010301	Walker B motif; other site
1049565010302	arginine finger; other site
1049565010303	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1049565010304	acetyl-CoA:acetoacetyl-CoA transferase subunit alpha; Provisional; Region: PRK09920
1049565010305	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
1049565010306	Short chain fatty acid transporter; Region: SCFA_trans; pfam02667
1049565010307	putative acyltransferase; Provisional; Region: PRK05790
1049565010308	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1049565010309	dimer interface [polypeptide binding]; other site
1049565010310	active site
1049565010311	DNA gyrase subunit A; Validated; Region: PRK05560
1049565010312	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1049565010313	CAP-like domain; other site
1049565010314	active site
1049565010315	primary dimer interface [polypeptide binding]; other site
1049565010316	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1049565010317	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1049565010318	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1049565010319	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1049565010320	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1049565010321	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1049565010322	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
1049565010323	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1049565010324	S-adenosylmethionine binding site [chemical binding]; other site
1049565010325	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103
1049565010326	ATP cone domain; Region: ATP-cone; pfam03477
1049565010327	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1049565010328	active site
1049565010329	dimer interface [polypeptide binding]; other site
1049565010330	catalytic residues [active]
1049565010331	effector binding site; other site
1049565010332	R2 peptide binding site; other site
1049565010333	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1049565010334	dimer interface [polypeptide binding]; other site
1049565010335	putative radical transfer pathway; other site
1049565010336	diiron center [ion binding]; other site
1049565010337	tyrosyl radical; other site
1049565010338	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1049565010339	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1049565010340	catalytic loop [active]
1049565010341	iron binding site [ion binding]; other site
1049565010342	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
1049565010343	Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600
1049565010344	active site
1049565010345	catalytic site [active]
1049565010346	metal binding site [ion binding]; metal-binding site
1049565010347	sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273
1049565010348	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565010349	putative substrate translocation pore; other site
1049565010350	sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101
1049565010351	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1049565010352	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1049565010353	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075
1049565010354	anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329
1049565010355	glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379
1049565010356	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1049565010357	Cysteine-rich domain; Region: CCG; pfam02754
1049565010358	Cysteine-rich domain; Region: CCG; pfam02754
1049565010359	2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128
1049565010360	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
1049565010361	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565010362	putative substrate translocation pore; other site
1049565010363	L-rhamnonate dehydratase; Provisional; Region: PRK15440
1049565010364	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327
1049565010365	putative active site pocket [active]
1049565010366	putative metal binding site [ion binding]; other site
1049565010367	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1049565010368	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1049565010369	Bacterial transcriptional regulator; Region: IclR; pfam01614
1049565010370	hypothetical protein; Provisional; Region: PRK03673
1049565010371	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
1049565010372	putative MPT binding site; other site
1049565010373	Competence-damaged protein; Region: CinA; pfam02464
1049565010374	YfaZ precursor; Region: YfaZ; pfam07437
1049565010375	Organic solvent tolerance protein; Region: OstA_C; pfam04453
1049565010376	putative transposase; Provisional; Region: PRK09857
1049565010377	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
1049565010378	nucleoside triphosphatase NudI; Provisional; Region: PRK15472
1049565010379	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029
1049565010380	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
1049565010381	acyl-activating enzyme (AAE) consensus motif; other site
1049565010382	putative AMP binding site [chemical binding]; other site
1049565010383	putative active site [active]
1049565010384	putative CoA binding site [chemical binding]; other site
1049565010385	O-succinylbenzoate synthase; Provisional; Region: PRK05105
1049565010386	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
1049565010387	active site
1049565010388	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1049565010389	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
1049565010390	substrate binding site [chemical binding]; other site
1049565010391	oxyanion hole (OAH) forming residues; other site
1049565010392	trimer interface [polypeptide binding]; other site
1049565010393	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126
1049565010394	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
1049565010395	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
1049565010396	dimer interface [polypeptide binding]; other site
1049565010397	tetramer interface [polypeptide binding]; other site
1049565010398	PYR/PP interface [polypeptide binding]; other site
1049565010399	TPP binding site [chemical binding]; other site
1049565010400	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
1049565010401	TPP-binding site; other site
1049565010402	menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012
1049565010403	chorismate binding enzyme; Region: Chorismate_bind; cl10555
1049565010404	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1049565010405	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1049565010406	Coenzyme A binding pocket [chemical binding]; other site
1049565010407	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1049565010408	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
1049565010409	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1049565010410	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
1049565010411	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1049565010412	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
1049565010413	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
1049565010414	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1049565010415	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
1049565010416	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
1049565010417	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
1049565010418	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
1049565010419	4Fe-4S binding domain; Region: Fer4; pfam00037
1049565010420	4Fe-4S binding domain; Region: Fer4; pfam00037
1049565010421	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
1049565010422	NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034
1049565010423	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1049565010424	catalytic loop [active]
1049565010425	iron binding site [ion binding]; other site
1049565010426	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
1049565010427	MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771
1049565010428	[4Fe-4S] binding site [ion binding]; other site
1049565010429	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
1049565010430	NADH dehydrogenase I subunit F; Provisional; Region: PRK11278
1049565010431	SLBB domain; Region: SLBB; pfam10531
1049565010432	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
1049565010433	NADH dehydrogenase subunit E; Validated; Region: PRK07539
1049565010434	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
1049565010435	putative dimer interface [polypeptide binding]; other site
1049565010436	[2Fe-2S] cluster binding site [ion binding]; other site
1049565010437	bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742
1049565010438	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
1049565010439	NADH dehydrogenase subunit D; Validated; Region: PRK06075
1049565010440	NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377
1049565010441	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
1049565010442	DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092
1049565010443	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565010444	The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439
1049565010445	putative dimerization interface [polypeptide binding]; other site
1049565010446	aminotransferase AlaT; Validated; Region: PRK09265
1049565010447	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1049565010448	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565010449	homodimer interface [polypeptide binding]; other site
1049565010450	catalytic residue [active]
1049565010451	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1049565010452	Zn2+ binding site [ion binding]; other site
1049565010453	Mg2+ binding site [ion binding]; other site
1049565010454	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
1049565010455	transmembrane helices; other site
1049565010456	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1049565010457	TrkA-C domain; Region: TrkA_C; pfam02080
1049565010458	TrkA-C domain; Region: TrkA_C; pfam02080
1049565010459	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1049565010460	putative phosphatase; Provisional; Region: PRK11587
1049565010461	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1049565010462	motif II; other site
1049565010463	hypothetical protein; Validated; Region: PRK05445
1049565010464	hypothetical protein; Provisional; Region: PRK01816
1049565010465	propionate/acetate kinase; Provisional; Region: PRK12379
1049565010466	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1049565010467	phosphate acetyltransferase; Reviewed; Region: PRK05632
1049565010468	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1049565010469	DRTGG domain; Region: DRTGG; pfam07085
1049565010470	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
1049565010471	NUDIX hydrolase YfcD; Provisional; Region: PRK15393
1049565010472	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697
1049565010473	nudix motif; other site
1049565010474	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
1049565010475	active site
1049565010476	metal binding site [ion binding]; metal-binding site
1049565010477	homotetramer interface [polypeptide binding]; other site
1049565010478	glutathione S-transferase; Provisional; Region: PRK15113
1049565010479	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
1049565010480	C-terminal domain interface [polypeptide binding]; other site
1049565010481	GSH binding site (G-site) [chemical binding]; other site
1049565010482	dimer interface [polypeptide binding]; other site
1049565010483	C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195
1049565010484	N-terminal domain interface [polypeptide binding]; other site
1049565010485	putative dimer interface [polypeptide binding]; other site
1049565010486	putative substrate binding pocket (H-site) [chemical binding]; other site
1049565010487	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
1049565010488	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
1049565010489	C-terminal domain interface [polypeptide binding]; other site
1049565010490	GSH binding site (G-site) [chemical binding]; other site
1049565010491	dimer interface [polypeptide binding]; other site
1049565010492	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
1049565010493	N-terminal domain interface [polypeptide binding]; other site
1049565010494	putative dimer interface [polypeptide binding]; other site
1049565010495	active site
1049565010496	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
1049565010497	homooctamer interface [polypeptide binding]; other site
1049565010498	active site
1049565010499	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
1049565010500	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
1049565010501	putative NAD(P) binding site [chemical binding]; other site
1049565010502	putative active site [active]
1049565010503	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1049565010504	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1049565010505	Coenzyme A binding pocket [chemical binding]; other site
1049565010506	histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619
1049565010507	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1049565010508	Walker A/P-loop; other site
1049565010509	ATP binding site [chemical binding]; other site
1049565010510	Q-loop/lid; other site
1049565010511	ABC transporter signature motif; other site
1049565010512	Walker B; other site
1049565010513	D-loop; other site
1049565010514	H-loop/switch region; other site
1049565010515	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1049565010516	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565010517	dimer interface [polypeptide binding]; other site
1049565010518	conserved gate region; other site
1049565010519	putative PBP binding loops; other site
1049565010520	ABC-ATPase subunit interface; other site
1049565010521	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1049565010522	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565010523	dimer interface [polypeptide binding]; other site
1049565010524	conserved gate region; other site
1049565010525	putative PBP binding loops; other site
1049565010526	ABC-ATPase subunit interface; other site
1049565010527	histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437
1049565010528	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1049565010529	substrate binding pocket [chemical binding]; other site
1049565010530	membrane-bound complex binding site; other site
1049565010531	hinge residues; other site
1049565010532	ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010
1049565010533	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1049565010534	substrate binding pocket [chemical binding]; other site
1049565010535	membrane-bound complex binding site; other site
1049565010536	hinge residues; other site
1049565010537	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
1049565010538	Flavoprotein; Region: Flavoprotein; pfam02441
1049565010539	amidophosphoribosyltransferase; Provisional; Region: PRK09246
1049565010540	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1049565010541	active site
1049565010542	tetramer interface [polypeptide binding]; other site
1049565010543	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1049565010544	active site
1049565010545	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
1049565010546	colicin V production protein; Provisional; Region: PRK10845
1049565010547	cell division protein DedD; Provisional; Region: PRK11633
1049565010548	Sporulation related domain; Region: SPOR; pfam05036
1049565010549	bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846
1049565010550	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1049565010551	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1049565010552	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
1049565010553	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1049565010554	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1049565010555	hypothetical protein; Provisional; Region: PRK10847
1049565010556	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1049565010557	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1049565010558	dimerization interface 3.5A [polypeptide binding]; other site
1049565010559	active site
1049565010560	putative semialdehyde dehydrogenase; Provisional; Region: PRK08040
1049565010561	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1049565010562	erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438
1049565010563	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
1049565010564	ligand binding site [chemical binding]; other site
1049565010565	NAD binding site [chemical binding]; other site
1049565010566	catalytic site [active]
1049565010567	homodimer interface [polypeptide binding]; other site
1049565010568	flagella biosynthesis regulator; Provisional; Region: flk; PRK10715
1049565010569	putative transporter; Provisional; Region: PRK12382
1049565010570	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
1049565010571	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1049565010572	dimer interface [polypeptide binding]; other site
1049565010573	active site
1049565010574	Uncharacterized conserved protein [Function unknown]; Region: COG4121
1049565010575	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
1049565010576	YfcL protein; Region: YfcL; pfam08891
1049565010577	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101
1049565010578	hypothetical protein; Provisional; Region: PRK10621
1049565010579	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1049565010580	Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770
1049565010581	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
1049565010582	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1049565010583	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1049565010584	Tetramer interface [polypeptide binding]; other site
1049565010585	active site
1049565010586	FMN-binding site [chemical binding]; other site
1049565010587	HemK family putative methylases; Region: hemK_fam; TIGR00536
1049565010588	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1049565010589	S-adenosylmethionine binding site [chemical binding]; other site
1049565010590	hypothetical protein; Provisional; Region: PRK04946
1049565010591	Smr domain; Region: Smr; pfam01713
1049565010592	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1049565010593	catalytic core [active]
1049565010594	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
1049565010595	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1049565010596	substrate binding site [chemical binding]; other site
1049565010597	oxyanion hole (OAH) forming residues; other site
1049565010598	trimer interface [polypeptide binding]; other site
1049565010599	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1049565010600	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1049565010601	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1049565010602	3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963
1049565010603	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1049565010604	dimer interface [polypeptide binding]; other site
1049565010605	active site
1049565010606	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691
1049565010607	long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716
1049565010608	ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091
1049565010609	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
1049565010610	cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366
1049565010611	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
1049565010612	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565010613	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1049565010614	dimerization interface [polypeptide binding]; other site
1049565010615	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1049565010616	nucleoside/Zn binding site; other site
1049565010617	dimer interface [polypeptide binding]; other site
1049565010618	catalytic motif [active]
1049565010619	putative cyanate transporter; Provisional; Region: cynX; PRK09705
1049565010620	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565010621	aminotransferase; Validated; Region: PRK08175
1049565010622	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1049565010623	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565010624	homodimer interface [polypeptide binding]; other site
1049565010625	catalytic residue [active]
1049565010626	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
1049565010627	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1049565010628	Histidine kinase; Region: His_kinase; pfam06580
1049565010629	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1049565010630	ATP binding site [chemical binding]; other site
1049565010631	Mg2+ binding site [ion binding]; other site
1049565010632	G-X-G motif; other site
1049565010633	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1049565010634	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1049565010635	active site
1049565010636	phosphorylation site [posttranslational modification]
1049565010637	intermolecular recognition site; other site
1049565010638	dimerization interface [polypeptide binding]; other site
1049565010639	LytTr DNA-binding domain; Region: LytTR; pfam04397
1049565010640	glucokinase; Provisional; Region: glk; PRK00292
1049565010641	glucokinase, proteobacterial type; Region: glk; TIGR00749
1049565010642	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1049565010643	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
1049565010644	Cl- selectivity filter; other site
1049565010645	Cl- binding residues [ion binding]; other site
1049565010646	pore gating glutamate residue; other site
1049565010647	dimer interface [polypeptide binding]; other site
1049565010648	indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393
1049565010649	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
1049565010650	dimer interface [polypeptide binding]; other site
1049565010651	PYR/PP interface [polypeptide binding]; other site
1049565010652	TPP binding site [chemical binding]; other site
1049565010653	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1049565010654	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
1049565010655	TPP-binding site [chemical binding]; other site
1049565010656	dimer interface [polypeptide binding]; other site
1049565010657	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1049565010658	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1049565010659	active site
1049565010660	catalytic tetrad [active]
1049565010661	Protein of unknown function (DUF2502); Region: DUF2502; pfam10697
1049565010662	manganese transport protein MntH; Reviewed; Region: PRK00701
1049565010663	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1049565010664	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1049565010665	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1049565010666	Nucleoside recognition; Region: Gate; pfam07670
1049565010667	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1049565010668	MASE1; Region: MASE1; pfam05231
1049565010669	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1049565010670	diguanylate cyclase; Region: GGDEF; smart00267
1049565010671	metal binding site [ion binding]; metal-binding site
1049565010672	nucleotidyl binding site; other site
1049565010673	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1049565010674	Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037
1049565010675	Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037
1049565010676	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1049565010677	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1049565010678	active site
1049565010679	HIGH motif; other site
1049565010680	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1049565010681	active site
1049565010682	KMSKS motif; other site
1049565010683	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565010684	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565010685	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
1049565010686	putative dimerization interface [polypeptide binding]; other site
1049565010687	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
1049565010688	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
1049565010689	Protein of unknown function (DUF3820); Region: DUF3820; pfam12843
1049565010690	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1049565010691	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1049565010692	nucleotide binding pocket [chemical binding]; other site
1049565010693	K-X-D-G motif; other site
1049565010694	catalytic site [active]
1049565010695	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1049565010696	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1049565010697	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1049565010698	Dimer interface [polypeptide binding]; other site
1049565010699	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038
1049565010700	cell division protein ZipA; Provisional; Region: PRK03427
1049565010701	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231
1049565010702	FtsZ protein binding site [polypeptide binding]; other site
1049565010703	putative sulfate transport protein CysZ; Validated; Region: PRK04949
1049565010704	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1049565010705	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1049565010706	dimer interface [polypeptide binding]; other site
1049565010707	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565010708	catalytic residue [active]
1049565010709	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1049565010710	dimerization domain swap beta strand [polypeptide binding]; other site
1049565010711	regulatory protein interface [polypeptide binding]; other site
1049565010712	active site
1049565010713	regulatory phosphorylation site [posttranslational modification]; other site
1049565010714	phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177
1049565010715	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1049565010716	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1049565010717	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1049565010718	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
1049565010719	HPr interaction site; other site
1049565010720	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1049565010721	active site
1049565010722	phosphorylation site [posttranslational modification]
1049565010723	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
1049565010724	dimer interface [polypeptide binding]; other site
1049565010725	pyridoxamine kinase; Validated; Region: PRK05756
1049565010726	pyridoxal binding site [chemical binding]; other site
1049565010727	ATP binding site [chemical binding]; other site
1049565010728	transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481
1049565010729	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1049565010730	DNA-binding site [nucleotide binding]; DNA binding site
1049565010731	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1049565010732	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565010733	homodimer interface [polypeptide binding]; other site
1049565010734	catalytic residue [active]
1049565010735	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
1049565010736	cysteine synthase B; Region: cysM; TIGR01138
1049565010737	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1049565010738	dimer interface [polypeptide binding]; other site
1049565010739	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565010740	catalytic residue [active]
1049565010741	sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851
1049565010742	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
1049565010743	Walker A/P-loop; other site
1049565010744	ATP binding site [chemical binding]; other site
1049565010745	Q-loop/lid; other site
1049565010746	ABC transporter signature motif; other site
1049565010747	Walker B; other site
1049565010748	D-loop; other site
1049565010749	H-loop/switch region; other site
1049565010750	TOBE-like domain; Region: TOBE_3; pfam12857
1049565010751	sulfate transport protein; Provisional; Region: cysT; CHL00187
1049565010752	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565010753	dimer interface [polypeptide binding]; other site
1049565010754	conserved gate region; other site
1049565010755	putative PBP binding loops; other site
1049565010756	ABC-ATPase subunit interface; other site
1049565010757	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1049565010758	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565010759	dimer interface [polypeptide binding]; other site
1049565010760	conserved gate region; other site
1049565010761	putative PBP binding loops; other site
1049565010762	ABC-ATPase subunit interface; other site
1049565010763	thiosulfate transporter subunit; Provisional; Region: PRK10852
1049565010764	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1049565010765	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
1049565010766	RpoE-regulated lipoprotein; Provisional; Region: PRK10718
1049565010767	Protein of unknown function (DUF1131); Region: DUF1131; pfam06572
1049565010768	Protein of unknown function (DUF2919); Region: DUF2919; pfam11143
1049565010769	putative acetyltransferase; Provisional; Region: PRK03624
1049565010770	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1049565010771	Coenzyme A binding pocket [chemical binding]; other site
1049565010772	N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319
1049565010773	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1049565010774	active site
1049565010775	metal binding site [ion binding]; metal-binding site
1049565010776	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
1049565010777	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
1049565010778	transcriptional regulator EutR; Provisional; Region: PRK10130
1049565010779	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565010780	carboxysome structural protein EutK; Provisional; Region: PRK15466
1049565010781	Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982
1049565010782	Hexamer interface [polypeptide binding]; other site
1049565010783	Hexagonal pore residue; other site
1049565010784	ethanolamine utilization protein EutL; Provisional; Region: PRK15405
1049565010785	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049
1049565010786	putative hexamer interface [polypeptide binding]; other site
1049565010787	putative hexagonal pore; other site
1049565010788	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050
1049565010789	putative hexamer interface [polypeptide binding]; other site
1049565010790	putative hexagonal pore; other site
1049565010791	Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302
1049565010792	Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303
1049565010793	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
1049565010794	reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719
1049565010795	Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192
1049565010796	ethanol dehydrogenase EutG; Provisional; Region: PRK15454
1049565010797	iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551
1049565010798	active site
1049565010799	metal binding site [ion binding]; metal-binding site
1049565010800	Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820
1049565010801	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1049565010802	nucleotide binding site [chemical binding]; other site
1049565010803	aldehyde dehydrogenase EutE; Provisional; Region: PRK15398
1049565010804	NAD(P) binding site [chemical binding]; other site
1049565010805	catalytic residues [active]
1049565010806	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
1049565010807	Hexamer/Pentamer interface [polypeptide binding]; other site
1049565010808	central pore; other site
1049565010809	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
1049565010810	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
1049565010811	Hexamer interface [polypeptide binding]; other site
1049565010812	Hexagonal pore residue; other site
1049565010813	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
1049565010814	ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020
1049565010815	ethanolamine utilization protein EutQ; Provisional; Region: PRK15457
1049565010816	Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766
1049565010817	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
1049565010818	G1 box; other site
1049565010819	GTP/Mg2+ binding site [chemical binding]; other site
1049565010820	G2 box; other site
1049565010821	Switch I region; other site
1049565010822	G3 box; other site
1049565010823	Switch II region; other site
1049565010824	G4 box; other site
1049565010825	G5 box; other site
1049565010826	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
1049565010827	putative hexamer interface [polypeptide binding]; other site
1049565010828	putative hexagonal pore; other site
1049565010829	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
1049565010830	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1049565010831	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
1049565010832	putative NAD(P) binding site [chemical binding]; other site
1049565010833	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
1049565010834	transaldolase-like protein; Provisional; Region: PTZ00411
1049565010835	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
1049565010836	active site
1049565010837	dimer interface [polypeptide binding]; other site
1049565010838	catalytic residue [active]
1049565010839	transketolase; Reviewed; Region: PRK12753
1049565010840	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1049565010841	TPP-binding site [chemical binding]; other site
1049565010842	dimer interface [polypeptide binding]; other site
1049565010843	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1049565010844	PYR/PP interface [polypeptide binding]; other site
1049565010845	dimer interface [polypeptide binding]; other site
1049565010846	TPP binding site [chemical binding]; other site
1049565010847	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1049565010848	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
1049565010849	GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009
1049565010850	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1049565010851	dimer interface [polypeptide binding]; other site
1049565010852	ADP-ribose binding site [chemical binding]; other site
1049565010853	active site
1049565010854	nudix motif; other site
1049565010855	metal binding site [ion binding]; metal-binding site
1049565010856	putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769
1049565010857	4Fe-4S binding domain; Region: Fer4; pfam00037
1049565010858	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1049565010859	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1049565010860	aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555
1049565010861	Protein export membrane protein; Region: SecD_SecF; cl14618
1049565010862	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
1049565010863	ArsC family; Region: ArsC; pfam03960
1049565010864	putative catalytic residues [active]
1049565010865	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
1049565010866	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
1049565010867	metal binding site [ion binding]; metal-binding site
1049565010868	dimer interface [polypeptide binding]; other site
1049565010869	hypothetical protein; Provisional; Region: PRK13664
1049565010870	putative hydrolase; Provisional; Region: PRK11460
1049565010871	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
1049565010872	Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444
1049565010873	Domain of unknown function (DUF1726); Region: DUF1726; pfam08351
1049565010874	Helicase; Region: Helicase_RecD; pfam05127
1049565010875	GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718
1049565010876	Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725
1049565010877	Predicted metalloprotease [General function prediction only]; Region: COG2321
1049565010878	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
1049565010879	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
1049565010880	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
1049565010881	ATP binding site [chemical binding]; other site
1049565010882	active site
1049565010883	substrate binding site [chemical binding]; other site
1049565010884	lipoprotein; Provisional; Region: PRK11679
1049565010885	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
1049565010886	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1049565010887	dihydrodipicolinate synthase; Region: dapA; TIGR00674
1049565010888	dimer interface [polypeptide binding]; other site
1049565010889	active site
1049565010890	catalytic residue [active]
1049565010891	glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589
1049565010892	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893
1049565010893	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1049565010894	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1049565010895	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1049565010896	catalytic triad [active]
1049565010897	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1049565010898	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1049565010899	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
1049565010900	Peptidase family M48; Region: Peptidase_M48; cl12018
1049565010901	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
1049565010902	ArsC family; Region: ArsC; pfam03960
1049565010903	catalytic residues [active]
1049565010904	hypothetical protein; Provisional; Region: PRK09956
1049565010905	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
1049565010906	DNA replication initiation factor; Provisional; Region: PRK08084
1049565010907	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
1049565010908	uracil transporter; Provisional; Region: PRK10720
1049565010909	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1049565010910	active site
1049565010911	6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589
1049565010912	beta-galactosidase; Region: BGL; TIGR03356
1049565010913	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1049565010914	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1049565010915	nucleotide binding site [chemical binding]; other site
1049565010916	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
1049565010917	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1049565010918	dimerization interface [polypeptide binding]; other site
1049565010919	putative ATP binding site [chemical binding]; other site
1049565010920	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
1049565010921	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1049565010922	active site
1049565010923	substrate binding site [chemical binding]; other site
1049565010924	cosubstrate binding site; other site
1049565010925	catalytic site [active]
1049565010926	Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855
1049565010927	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
1049565010928	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
1049565010929	Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164
1049565010930	domain interface [polypeptide binding]; other site
1049565010931	active site
1049565010932	catalytic site [active]
1049565010933	Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167
1049565010934	domain interface [polypeptide binding]; other site
1049565010935	active site
1049565010936	catalytic site [active]
1049565010937	exopolyphosphatase; Provisional; Region: PRK10854
1049565010938	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1049565010939	potential frameshift: common BLAST hit: gi|238895955|ref|YP_002920691.1| putative cytochrome C-type biogenesis protein
1049565010940	Protein of unknown function (DUF2633); Region: DUF2633; pfam11119
1049565010941	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565010942	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565010943	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1049565010944	dimerization interface [polypeptide binding]; other site
1049565010945	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1049565010946	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565010947	putative substrate translocation pore; other site
1049565010948	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
1049565010949	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1049565010950	FeS/SAM binding site; other site
1049565010951	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
1049565010952	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
1049565010953	Sulfatase; Region: Sulfatase; cl17466
1049565010954	GMP synthase; Reviewed; Region: guaA; PRK00074
1049565010955	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1049565010956	AMP/PPi binding site [chemical binding]; other site
1049565010957	candidate oxyanion hole; other site
1049565010958	catalytic triad [active]
1049565010959	potential glutamine specificity residues [chemical binding]; other site
1049565010960	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1049565010961	ATP Binding subdomain [chemical binding]; other site
1049565010962	Ligand Binding sites [chemical binding]; other site
1049565010963	Dimerization subdomain; other site
1049565010964	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
1049565010965	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1049565010966	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
1049565010967	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1049565010968	active site
1049565010969	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
1049565010970	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1049565010971	generic binding surface II; other site
1049565010972	generic binding surface I; other site
1049565010973	Protein of unknown function (DUF1407); Region: DUF1407; pfam07191
1049565010974	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1049565010975	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1049565010976	GTP-binding protein Der; Reviewed; Region: PRK00093
1049565010977	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1049565010978	G1 box; other site
1049565010979	GTP/Mg2+ binding site [chemical binding]; other site
1049565010980	Switch I region; other site
1049565010981	G2 box; other site
1049565010982	Switch II region; other site
1049565010983	G3 box; other site
1049565010984	G4 box; other site
1049565010985	G5 box; other site
1049565010986	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1049565010987	G1 box; other site
1049565010988	GTP/Mg2+ binding site [chemical binding]; other site
1049565010989	Switch I region; other site
1049565010990	G2 box; other site
1049565010991	G3 box; other site
1049565010992	Switch II region; other site
1049565010993	G4 box; other site
1049565010994	G5 box; other site
1049565010995	outer membrane biogenesis protein BamB; Provisional; Region: PRK11138
1049565010996	Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276
1049565010997	Trp docking motif [polypeptide binding]; other site
1049565010998	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
1049565010999	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
1049565011000	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
1049565011001	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1049565011002	dimer interface [polypeptide binding]; other site
1049565011003	motif 1; other site
1049565011004	active site
1049565011005	motif 2; other site
1049565011006	motif 3; other site
1049565011007	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1049565011008	anticodon binding site; other site
1049565011009	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
1049565011010	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1049565011011	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1049565011012	cytoskeletal protein RodZ; Provisional; Region: PRK10856
1049565011013	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1049565011014	non-specific DNA binding site [nucleotide binding]; other site
1049565011015	salt bridge; other site
1049565011016	sequence-specific DNA binding site [nucleotide binding]; other site
1049565011017	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
1049565011018	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
1049565011019	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1049565011020	FeS/SAM binding site; other site
1049565011021	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1049565011022	active site
1049565011023	multimer interface [polypeptide binding]; other site
1049565011024	penicillin-binding protein 1C; Provisional; Region: PRK11240
1049565011025	Transglycosylase; Region: Transgly; pfam00912
1049565011026	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1049565011027	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
1049565011028	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
1049565011029	MG2 domain; Region: A2M_N; pfam01835
1049565011030	Alpha-2-macroglobulin family; Region: A2M; pfam00207
1049565011031	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
1049565011032	surface patch; other site
1049565011033	thioester region; other site
1049565011034	specificity defining residues; other site
1049565011035	3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493
1049565011036	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
1049565011037	active site residue [active]
1049565011038	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1049565011039	active site residue [active]
1049565011040	enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611
1049565011041	aminopeptidase B; Provisional; Region: PRK05015
1049565011042	Peptidase; Region: DUF3663; pfam12404
1049565011043	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1049565011044	interface (dimer of trimers) [polypeptide binding]; other site
1049565011045	Substrate-binding/catalytic site; other site
1049565011046	Zn-binding sites [ion binding]; other site
1049565011047	hypothetical protein; Provisional; Region: PRK10721
1049565011048	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1049565011049	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1049565011050	catalytic loop [active]
1049565011051	iron binding site [ion binding]; other site
1049565011052	chaperone protein HscA; Provisional; Region: hscA; PRK05183
1049565011053	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
1049565011054	nucleotide binding site [chemical binding]; other site
1049565011055	putative NEF/HSP70 interaction site [polypeptide binding]; other site
1049565011056	SBD interface [polypeptide binding]; other site
1049565011057	co-chaperone HscB; Provisional; Region: hscB; PRK05014
1049565011058	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1049565011059	HSP70 interaction site [polypeptide binding]; other site
1049565011060	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
1049565011061	iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502
1049565011062	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
1049565011063	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1049565011064	trimerization site [polypeptide binding]; other site
1049565011065	active site
1049565011066	cysteine desulfurase; Provisional; Region: PRK14012
1049565011067	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1049565011068	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1049565011069	catalytic residue [active]
1049565011070	DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857
1049565011071	Rrf2 family protein; Region: rrf2_super; TIGR00738
1049565011072	tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114
1049565011073	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
1049565011074	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1049565011075	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
1049565011076	active site
1049565011077	dimerization interface [polypeptide binding]; other site
1049565011078	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215
1049565011079	Protein of unknown function (DUF1007); Region: DUF1007; pfam06226
1049565011080	stationary phase inducible protein CsiE; Provisional; Region: PRK11564
1049565011081	PRD domain; Region: PRD; pfam00874
1049565011082	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
1049565011083	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565011084	putative substrate translocation pore; other site
1049565011085	aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021
1049565011086	active site
1049565011087	catalytic residues [active]
1049565011088	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
1049565011089	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565011090	putative substrate translocation pore; other site
1049565011091	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565011092	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
1049565011093	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1049565011094	binding surface
1049565011095	TPR motif; other site
1049565011096	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1049565011097	binding surface
1049565011098	TPR motif; other site
1049565011099	TPR repeat; Region: TPR_11; pfam13414
1049565011100	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1049565011101	binding surface
1049565011102	TPR motif; other site
1049565011103	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
1049565011104	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1049565011105	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1049565011106	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1049565011107	Predicted membrane protein [Function unknown]; Region: COG2259
1049565011108	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1049565011109	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1049565011110	dimer interface [polypeptide binding]; other site
1049565011111	active site
1049565011112	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1049565011113	folate binding site [chemical binding]; other site
1049565011114	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
1049565011115	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
1049565011116	heme-binding site [chemical binding]; other site
1049565011117	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
1049565011118	FAD binding pocket [chemical binding]; other site
1049565011119	FAD binding motif [chemical binding]; other site
1049565011120	phosphate binding motif [ion binding]; other site
1049565011121	beta-alpha-beta structure motif; other site
1049565011122	NAD binding pocket [chemical binding]; other site
1049565011123	Heme binding  pocket [chemical binding]; other site
1049565011124	nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858
1049565011125	Nitrogen regulatory protein P-II; Region: P-II; smart00938
1049565011126	response regulator GlrR; Provisional; Region: PRK15115
1049565011127	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1049565011128	active site
1049565011129	phosphorylation site [posttranslational modification]
1049565011130	intermolecular recognition site; other site
1049565011131	dimerization interface [polypeptide binding]; other site
1049565011132	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1049565011133	Walker A motif; other site
1049565011134	ATP binding site [chemical binding]; other site
1049565011135	Walker B motif; other site
1049565011136	arginine finger; other site
1049565011137	hypothetical protein; Provisional; Region: PRK10722
1049565011138	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1049565011139	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1049565011140	dimer interface [polypeptide binding]; other site
1049565011141	phosphorylation site [posttranslational modification]
1049565011142	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1049565011143	ATP binding site [chemical binding]; other site
1049565011144	Mg2+ binding site [ion binding]; other site
1049565011145	G-X-G motif; other site
1049565011146	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
1049565011147	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1049565011148	dimerization interface [polypeptide binding]; other site
1049565011149	ATP binding site [chemical binding]; other site
1049565011150	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
1049565011151	dimerization interface [polypeptide binding]; other site
1049565011152	ATP binding site [chemical binding]; other site
1049565011153	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1049565011154	putative active site [active]
1049565011155	catalytic triad [active]
1049565011156	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
1049565011157	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1049565011158	substrate binding pocket [chemical binding]; other site
1049565011159	membrane-bound complex binding site; other site
1049565011160	hinge residues; other site
1049565011161	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1049565011162	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1049565011163	catalytic residue [active]
1049565011164	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1049565011165	nucleoside/Zn binding site; other site
1049565011166	dimer interface [polypeptide binding]; other site
1049565011167	catalytic motif [active]
1049565011168	hypothetical protein; Provisional; Region: PRK11590
1049565011169	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
1049565011170	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1049565011171	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557
1049565011172	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1049565011173	putative active site [active]
1049565011174	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1049565011175	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
1049565011176	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
1049565011177	active site
1049565011178	hydrophilic channel; other site
1049565011179	dimerization interface [polypeptide binding]; other site
1049565011180	catalytic residues [active]
1049565011181	active site lid [active]
1049565011182	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
1049565011183	Recombination protein O N terminal; Region: RecO_N; pfam11967
1049565011184	Recombination protein O C terminal; Region: RecO_C; pfam02565
1049565011185	GTPase Era; Reviewed; Region: era; PRK00089
1049565011186	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1049565011187	G1 box; other site
1049565011188	GTP/Mg2+ binding site [chemical binding]; other site
1049565011189	Switch I region; other site
1049565011190	G2 box; other site
1049565011191	Switch II region; other site
1049565011192	G3 box; other site
1049565011193	G4 box; other site
1049565011194	G5 box; other site
1049565011195	KH domain; Region: KH_2; pfam07650
1049565011196	ribonuclease III; Reviewed; Region: rnc; PRK00102
1049565011197	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1049565011198	dimerization interface [polypeptide binding]; other site
1049565011199	active site
1049565011200	metal binding site [ion binding]; metal-binding site
1049565011201	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1049565011202	dsRNA binding site [nucleotide binding]; other site
1049565011203	signal peptidase I; Provisional; Region: PRK10861
1049565011204	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1049565011205	Catalytic site [active]
1049565011206	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1049565011207	GTP-binding protein LepA; Provisional; Region: PRK05433
1049565011208	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1049565011209	G1 box; other site
1049565011210	putative GEF interaction site [polypeptide binding]; other site
1049565011211	GTP/Mg2+ binding site [chemical binding]; other site
1049565011212	Switch I region; other site
1049565011213	G2 box; other site
1049565011214	G3 box; other site
1049565011215	Switch II region; other site
1049565011216	G4 box; other site
1049565011217	G5 box; other site
1049565011218	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1049565011219	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1049565011220	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1049565011221	SoxR reducing system protein RseC; Provisional; Region: PRK10862
1049565011222	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026
1049565011223	anti-sigma E factor; Provisional; Region: rseB; PRK09455
1049565011224	anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863
1049565011225	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
1049565011226	Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873
1049565011227	RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939
1049565011228	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1049565011229	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1049565011230	DNA binding residues [nucleotide binding]
1049565011231	L-aspartate oxidase; Provisional; Region: PRK09077
1049565011232	L-aspartate oxidase; Provisional; Region: PRK06175
1049565011233	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1049565011234	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
1049565011235	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1049565011236	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
1049565011237	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1049565011238	ATP binding site [chemical binding]; other site
1049565011239	Mg++ binding site [ion binding]; other site
1049565011240	motif III; other site
1049565011241	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1049565011242	nucleotide binding region [chemical binding]; other site
1049565011243	ATP-binding site [chemical binding]; other site
1049565011244	autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127
1049565011245	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
1049565011246	ligand binding site [chemical binding]; other site
1049565011247	active site
1049565011248	UGI interface [polypeptide binding]; other site
1049565011249	catalytic site [active]
1049565011250	putative methyltransferase; Provisional; Region: PRK10864
1049565011251	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1049565011252	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1049565011253	thioredoxin 2; Provisional; Region: PRK10996
1049565011254	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1049565011255	catalytic residues [active]
1049565011256	Uncharacterized conserved protein [Function unknown]; Region: COG3148
1049565011257	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
1049565011258	CoA binding domain; Region: CoA_binding_2; pfam13380
1049565011259	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
1049565011260	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
1049565011261	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1049565011262	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1049565011263	phosphatidylserine synthase; Provisional; Region: pssA; PRK09428
1049565011264	Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134
1049565011265	domain interface [polypeptide binding]; other site
1049565011266	putative active site [active]
1049565011267	catalytic site [active]
1049565011268	Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136
1049565011269	domain interface [polypeptide binding]; other site
1049565011270	putative active site [active]
1049565011271	catalytic site [active]
1049565011272	lipoprotein; Provisional; Region: PRK10759
1049565011273	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
1049565011274	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565011275	putative substrate translocation pore; other site
1049565011276	protein disaggregation chaperone; Provisional; Region: PRK10865
1049565011277	Clp amino terminal domain; Region: Clp_N; pfam02861
1049565011278	Clp amino terminal domain; Region: Clp_N; pfam02861
1049565011279	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1049565011280	Walker A motif; other site
1049565011281	ATP binding site [chemical binding]; other site
1049565011282	Walker B motif; other site
1049565011283	arginine finger; other site
1049565011284	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1049565011285	Walker A motif; other site
1049565011286	ATP binding site [chemical binding]; other site
1049565011287	Walker B motif; other site
1049565011288	arginine finger; other site
1049565011289	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1049565011290	hypothetical protein; Provisional; Region: PRK10723
1049565011291	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
1049565011292	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
1049565011293	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1049565011294	RNA binding surface [nucleotide binding]; other site
1049565011295	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1049565011296	active site
1049565011297	outer membrane biogenesis protein BamD; Provisional; Region: PRK10866
1049565011298	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1049565011299	30S subunit binding site; other site
1049565011300	bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622
1049565011301	chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797
1049565011302	Prephenate dehydratase; Region: PDT; pfam00800
1049565011303	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
1049565011304	putative L-Phe binding site [chemical binding]; other site
1049565011305	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
1049565011306	potential frameshift: common BLAST hit: gi|336246717|ref|YP_004590427.1| bifunctional chorismate mutase/prephenate dehydrogenase
1049565011307	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
1049565011308	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1049565011309	putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966
1049565011310	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1049565011311	metal binding site [ion binding]; metal-binding site
1049565011312	active site
1049565011313	I-site; other site
1049565011314	putative outer membrane lipoprotein; Provisional; Region: PRK09967
1049565011315	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1049565011316	ligand binding site [chemical binding]; other site
1049565011317	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
1049565011318	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
1049565011319	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
1049565011320	Protein of unknown function (DUF2946); Region: DUF2946; pfam11162
1049565011321	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1049565011322	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1049565011323	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1049565011324	RimM N-terminal domain; Region: RimM; pfam01782
1049565011325	PRC-barrel domain; Region: PRC; pfam05239
1049565011326	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
1049565011327	signal recognition particle protein; Provisional; Region: PRK10867
1049565011328	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1049565011329	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1049565011330	P loop; other site
1049565011331	GTP binding site [chemical binding]; other site
1049565011332	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1049565011333	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137
1049565011334	hypothetical protein; Provisional; Region: PRK11573
1049565011335	Domain of unknown function DUF21; Region: DUF21; pfam01595
1049565011336	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1049565011337	Transporter associated domain; Region: CorC_HlyC; smart01091
1049565011338	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
1049565011339	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1049565011340	dimer interface [polypeptide binding]; other site
1049565011341	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1049565011342	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378
1049565011343	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
1049565011344	recombination and repair protein; Provisional; Region: PRK10869
1049565011345	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1049565011346	Walker A/P-loop; other site
1049565011347	ATP binding site [chemical binding]; other site
1049565011348	Q-loop/lid; other site
1049565011349	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1049565011350	ABC transporter signature motif; other site
1049565011351	Walker B; other site
1049565011352	D-loop; other site
1049565011353	H-loop/switch region; other site
1049565011354	outer membrane biogenesis protein BamE; Provisional; Region: PRK11548
1049565011355	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
1049565011356	hypothetical protein; Validated; Region: PRK01777
1049565011357	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
1049565011358	putative coenzyme Q binding site [chemical binding]; other site
1049565011359	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1049565011360	SmpB-tmRNA interface; other site
1049565011361	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
1049565011362	active site
1049565011363	Int/Topo IB signature motif; other site
1049565011364	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1049565011365	NACHT domain; Region: NACHT; pfam05729
1049565011366	Walker A motif; other site
1049565011367	ATP binding site [chemical binding]; other site
1049565011368	Walker B motif; other site
1049565011369	arginine finger; other site
1049565011370	Phage polarity suppression protein (Psu); Region: Psu; pfam07455
1049565011371	potential frameshift: common BLAST hit: gi|146312751|ref|YP_001177825.1| plasmid and phage DNA primase
1049565011372	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
1049565011373	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565011374	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565011375	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
1049565011376	putative effector binding pocket; other site
1049565011377	putative dimerization interface [polypeptide binding]; other site
1049565011378	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
1049565011379	DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219
1049565011380	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565011381	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1049565011382	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1049565011383	HlyD family secretion protein; Region: HlyD_3; pfam13437
1049565011384	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1049565011385	Predicted transcriptional regulator [Transcription]; Region: COG1959
1049565011386	Transcriptional regulator; Region: Rrf2; pfam02082
1049565011387	Transcriptional regulator; Region: Rrf2; cl17282
1049565011388	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565011389	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565011390	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1049565011391	dimerization interface [polypeptide binding]; other site
1049565011392	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
1049565011393	agmatinase; Region: agmatinase; TIGR01230
1049565011394	oligomer interface [polypeptide binding]; other site
1049565011395	putative active site [active]
1049565011396	Mn binding site [ion binding]; other site
1049565011397	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1049565011398	oxidase reductase; Provisional; Region: PTZ00273
1049565011399	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
1049565011400	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
1049565011401	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1049565011402	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1049565011403	substrate binding pocket [chemical binding]; other site
1049565011404	membrane-bound complex binding site; other site
1049565011405	hinge residues; other site
1049565011406	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565011407	dimer interface [polypeptide binding]; other site
1049565011408	conserved gate region; other site
1049565011409	ABC-ATPase subunit interface; other site
1049565011410	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1049565011411	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1049565011412	Walker A/P-loop; other site
1049565011413	ATP binding site [chemical binding]; other site
1049565011414	Q-loop/lid; other site
1049565011415	ABC transporter signature motif; other site
1049565011416	Walker B; other site
1049565011417	D-loop; other site
1049565011418	H-loop/switch region; other site
1049565011419	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
1049565011420	intersubunit interface [polypeptide binding]; other site
1049565011421	active site
1049565011422	Zn2+ binding site [ion binding]; other site
1049565011423	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
1049565011424	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1049565011425	putative ligand binding site [chemical binding]; other site
1049565011426	NAD binding site [chemical binding]; other site
1049565011427	dimerization interface [polypeptide binding]; other site
1049565011428	catalytic site [active]
1049565011429	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1049565011430	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1049565011431	NAD(P) binding site [chemical binding]; other site
1049565011432	active site
1049565011433	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1049565011434	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1049565011435	substrate binding pocket [chemical binding]; other site
1049565011436	membrane-bound complex binding site; other site
1049565011437	hinge residues; other site
1049565011438	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
1049565011439	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
1049565011440	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
1049565011441	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
1049565011442	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
1049565011443	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
1049565011444	PapC N-terminal domain; Region: PapC_N; pfam13954
1049565011445	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
1049565011446	PapC C-terminal domain; Region: PapC_C; pfam13953
1049565011447	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
1049565011448	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
1049565011449	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
1049565011450	Fimbrial protein; Region: Fimbrial; cl01416
1049565011451	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1049565011452	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1049565011453	NAD(P) binding site [chemical binding]; other site
1049565011454	catalytic residues [active]
1049565011455	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
1049565011456	GAF domain; Region: GAF; pfam01590
1049565011457	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1049565011458	Walker A motif; other site
1049565011459	ATP binding site [chemical binding]; other site
1049565011460	Walker B motif; other site
1049565011461	arginine finger; other site
1049565011462	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1049565011463	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565011464	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565011465	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475
1049565011466	putative effector binding pocket; other site
1049565011467	putative dimerization interface [polypeptide binding]; other site
1049565011468	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1049565011469	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1049565011470	dimerization interface [polypeptide binding]; other site
1049565011471	putative DNA binding site [nucleotide binding]; other site
1049565011472	putative Zn2+ binding site [ion binding]; other site
1049565011473	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1049565011474	active site residue [active]
1049565011475	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
1049565011476	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
1049565011477	DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328
1049565011478	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
1049565011479	Protein of unknown function (DUF1144); Region: DUF1144; pfam06610
1049565011480	hypothetical protein; Provisional; Region: PRK10556
1049565011481	hypothetical protein; Provisional; Region: PRK10132
1049565011482	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1049565011483	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1049565011484	DNA-binding site [nucleotide binding]; DNA binding site
1049565011485	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1049565011486	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565011487	homodimer interface [polypeptide binding]; other site
1049565011488	catalytic residue [active]
1049565011489	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1049565011490	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1049565011491	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
1049565011492	catalytic residues [active]
1049565011493	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
1049565011494	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
1049565011495	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
1049565011496	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1049565011497	active site
1049565011498	dimer interface [polypeptide binding]; other site
1049565011499	catalytic residues [active]
1049565011500	effector binding site; other site
1049565011501	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
1049565011502	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
1049565011503	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1049565011504	dimer interface [polypeptide binding]; other site
1049565011505	putative radical transfer pathway; other site
1049565011506	diiron center [ion binding]; other site
1049565011507	tyrosyl radical; other site
1049565011508	glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070
1049565011509	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
1049565011510	Walker A/P-loop; other site
1049565011511	ATP binding site [chemical binding]; other site
1049565011512	Q-loop/lid; other site
1049565011513	ABC transporter signature motif; other site
1049565011514	Walker B; other site
1049565011515	D-loop; other site
1049565011516	H-loop/switch region; other site
1049565011517	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
1049565011518	glycine betaine transporter membrane protein; Provisional; Region: PRK10952
1049565011519	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565011520	dimer interface [polypeptide binding]; other site
1049565011521	conserved gate region; other site
1049565011522	putative PBP binding loops; other site
1049565011523	ABC-ATPase subunit interface; other site
1049565011524	glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119
1049565011525	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1049565011526	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
1049565011527	putative L-valine exporter; Provisional; Region: PRK10408
1049565011528	transcriptional repressor MprA; Provisional; Region: PRK10870
1049565011529	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1049565011530	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
1049565011531	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1049565011532	HlyD family secretion protein; Region: HlyD_3; pfam13437
1049565011533	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1049565011534	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565011535	putative substrate translocation pore; other site
1049565011536	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565011537	2-isopropylmalate synthase; Validated; Region: PRK03739
1049565011538	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
1049565011539	active site
1049565011540	catalytic residues [active]
1049565011541	metal binding site [ion binding]; metal-binding site
1049565011542	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
1049565011543	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1049565011544	Helix-turn-helix domain; Region: HTH_18; pfam12833
1049565011545	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565011546	S-ribosylhomocysteinase; Provisional; Region: PRK02260
1049565011547	glutamate--cysteine ligase; Provisional; Region: PRK02107
1049565011548	Predicted membrane protein [Function unknown]; Region: COG1238
1049565011549	fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725
1049565011550	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1049565011551	motif II; other site
1049565011552	BON domain; Region: BON; pfam04972
1049565011553	potential protein location (hypothetical protein KPN2242_18095 [Klebsiella pneumoniae KCTC 2242]) that overlaps RNA (tRNA-S)
1049565011554	carbon storage regulator; Provisional; Region: PRK01712
1049565011555	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1049565011556	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1049565011557	motif 1; other site
1049565011558	active site
1049565011559	motif 2; other site
1049565011560	motif 3; other site
1049565011561	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1049565011562	DHHA1 domain; Region: DHHA1; pfam02272
1049565011563	recombination regulator RecX; Reviewed; Region: recX; PRK00117
1049565011564	recombinase A; Provisional; Region: recA; PRK09354
1049565011565	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1049565011566	hexamer interface [polypeptide binding]; other site
1049565011567	Walker A motif; other site
1049565011568	ATP binding site [chemical binding]; other site
1049565011569	Walker B motif; other site
1049565011570	hypothetical protein; Validated; Region: PRK03661
1049565011571	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
1049565011572	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
1049565011573	metal binding site [ion binding]; metal-binding site
1049565011574	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1049565011575	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1049565011576	ABC-ATPase subunit  interface; other site
1049565011577	dimer interface [polypeptide binding]; other site
1049565011578	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1049565011579	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1049565011580	Transglycosylase SLT domain; Region: SLT_2; pfam13406
1049565011581	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1049565011582	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1049565011583	catalytic residue [active]
1049565011584	PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515
1049565011585	PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825
1049565011586	Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612
1049565011587	Nucleoside recognition; Region: Gate; pfam07670
1049565011588	Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663
1049565011589	PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377
1049565011590	sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384
1049565011591	Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322
1049565011592	putative NAD(P) binding site [chemical binding]; other site
1049565011593	active site
1049565011594	Glucitol operon activator protein (GutM); Region: GutM; cl01890
1049565011595	DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434
1049565011596	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1049565011597	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1049565011598	D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543
1049565011599	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
1049565011600	putative active site [active]
1049565011601	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
1049565011602	anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022
1049565011603	GAF domain; Region: GAF; pfam01590
1049565011604	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1049565011605	Walker A motif; other site
1049565011606	ATP binding site [chemical binding]; other site
1049565011607	Walker B motif; other site
1049565011608	arginine finger; other site
1049565011609	anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452
1049565011610	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1049565011611	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1049565011612	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
1049565011613	iron binding site [ion binding]; other site
1049565011614	NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965
1049565011615	UAF complex subunit Rrn10; Region: UAF_Rrn10; pfam05234
1049565011616	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1049565011617	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1049565011618	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
1049565011619	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
1049565011620	Acylphosphatase; Region: Acylphosphatase; pfam00708
1049565011621	HypF finger; Region: zf-HYPF; pfam07503
1049565011622	HypF finger; Region: zf-HYPF; pfam07503
1049565011623	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
1049565011624	formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330
1049565011625	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
1049565011626	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1049565011627	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1049565011628	DNA binding site [nucleotide binding]
1049565011629	domain linker motif; other site
1049565011630	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
1049565011631	dimerization interface (closed form) [polypeptide binding]; other site
1049565011632	ligand binding site [chemical binding]; other site
1049565011633	PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796
1049565011634	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1049565011635	active site turn [active]
1049565011636	phosphorylation site [posttranslational modification]
1049565011637	PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852
1049565011638	cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852
1049565011639	beta-galactosidase; Region: BGL; TIGR03356
1049565011640	Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845
1049565011641	Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067
1049565011642	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
1049565011643	nickel binding site [ion binding]; other site
1049565011644	formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084
1049565011645	Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260
1049565011646	formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387
1049565011647	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1049565011648	Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262
1049565011649	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
1049565011650	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
1049565011651	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
1049565011652	NADH dehydrogenase; Region: NADHdh; cl00469
1049565011653	formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042
1049565011654	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1049565011655	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
1049565011656	Transcriptional repressor of hyc and hyp operons; Region: HycA_repressor; pfam11046
1049565011657	Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671
1049565011658	hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681
1049565011659	hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463
1049565011660	hydrogenase assembly chaperone; Provisional; Region: PRK10409
1049565011661	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
1049565011662	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
1049565011663	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
1049565011664	dimerization interface [polypeptide binding]; other site
1049565011665	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
1049565011666	ATP binding site [chemical binding]; other site
1049565011667	formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429
1049565011668	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1049565011669	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1049565011670	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1049565011671	Walker A motif; other site
1049565011672	ATP binding site [chemical binding]; other site
1049565011673	Walker B motif; other site
1049565011674	arginine finger; other site
1049565011675	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
1049565011676	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
1049565011677	beta-galactosidase; Region: BGL; TIGR03356
1049565011678	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1049565011679	Interdomain contacts; other site
1049565011680	Cytokine receptor motif; other site
1049565011681	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
1049565011682	putative metal binding site [ion binding]; other site
1049565011683	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1049565011684	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1049565011685	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1049565011686	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
1049565011687	active site
1049565011688	P-loop; other site
1049565011689	phosphorylation site [posttranslational modification]
1049565011690	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1049565011691	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1049565011692	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166
1049565011693	methionine cluster; other site
1049565011694	active site
1049565011695	phosphorylation site [posttranslational modification]
1049565011696	metal binding site [ion binding]; metal-binding site
1049565011697	fructokinase; Reviewed; Region: PRK09557
1049565011698	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1049565011699	nucleotide binding site [chemical binding]; other site
1049565011700	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1049565011701	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1049565011702	DNA binding site [nucleotide binding]
1049565011703	domain linker motif; other site
1049565011704	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1049565011705	ligand binding site [chemical binding]; other site
1049565011706	dimerization interface [polypeptide binding]; other site
1049565011707	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
1049565011708	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
1049565011709	metal binding site [ion binding]; metal-binding site
1049565011710	manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056
1049565011711	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1049565011712	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1049565011713	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1049565011714	ABC-ATPase subunit  interface; other site
1049565011715	dimer interface [polypeptide binding]; other site
1049565011716	putative PBP binding regions; other site
1049565011717	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1049565011718	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1049565011719	ABC-ATPase subunit  interface; other site
1049565011720	dimer interface [polypeptide binding]; other site
1049565011721	putative PBP binding regions; other site
1049565011722	Nitrous oxide-stimulated promoter; Region: YgbA_NO; cl08119
1049565011723	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565011724	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565011725	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1049565011726	dimerization interface [polypeptide binding]; other site
1049565011727	Membrane transport protein; Region: Mem_trans; cl09117
1049565011728	acetolactate synthase catalytic subunit; Validated; Region: PRK08327
1049565011729	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1049565011730	PYR/PP interface [polypeptide binding]; other site
1049565011731	dimer interface [polypeptide binding]; other site
1049565011732	TPP binding site [chemical binding]; other site
1049565011733	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1049565011734	TPP-binding site [chemical binding]; other site
1049565011735	Rdx family; Region: Rdx; cl01407
1049565011736	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
1049565011737	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1049565011738	N-terminal plug; other site
1049565011739	ligand-binding site [chemical binding]; other site
1049565011740	Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720
1049565011741	Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171
1049565011742	Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171
1049565011743	Hemin binding protein HutB.  These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149
1049565011744	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1049565011745	putative hemin binding site; other site
1049565011746	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1049565011747	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1049565011748	ABC-ATPase subunit  interface; other site
1049565011749	dimer interface [polypeptide binding]; other site
1049565011750	putative PBP binding regions; other site
1049565011751	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
1049565011752	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1049565011753	Walker A/P-loop; other site
1049565011754	ATP binding site [chemical binding]; other site
1049565011755	Q-loop/lid; other site
1049565011756	ABC transporter signature motif; other site
1049565011757	Walker B; other site
1049565011758	D-loop; other site
1049565011759	H-loop/switch region; other site
1049565011760	Fic/DOC family; Region: Fic; pfam02661
1049565011761	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1049565011762	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1049565011763	Walker A motif; other site
1049565011764	ATP binding site [chemical binding]; other site
1049565011765	Walker B motif; other site
1049565011766	arginine finger; other site
1049565011767	Domain of unknown function (DUF4062); Region: DUF4062; pfam13271
1049565011768	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
1049565011769	Phage associated DNA primase [General function prediction only]; Region: COG3378
1049565011770	Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834
1049565011771	Integrase; Region: Integrase_1; pfam12835
1049565011772	integrase; Provisional; Region: PRK09692
1049565011773	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
1049565011774	active site
1049565011775	Int/Topo IB signature motif; other site
1049565011776	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
1049565011777	MutS domain I; Region: MutS_I; pfam01624
1049565011778	MutS domain II; Region: MutS_II; pfam05188
1049565011779	MutS domain III; Region: MutS_III; pfam05192
1049565011780	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
1049565011781	Walker A/P-loop; other site
1049565011782	ATP binding site [chemical binding]; other site
1049565011783	Q-loop/lid; other site
1049565011784	ABC transporter signature motif; other site
1049565011785	Walker B; other site
1049565011786	D-loop; other site
1049565011787	H-loop/switch region; other site
1049565011788	Hok/gef family; Region: HOK_GEF; pfam01848
1049565011789	Protein of unknown function (DUF1062); Region: DUF1062; cl01786
1049565011790	3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043
1049565011791	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
1049565011792	Flavoprotein; Region: Flavoprotein; pfam02441
1049565011793	MarR family; Region: MarR_2; cl17246
1049565011794	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1049565011795	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565011796	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565011797	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1049565011798	putative effector binding pocket; other site
1049565011799	dimerization interface [polypeptide binding]; other site
1049565011800	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1049565011801	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565011802	putative substrate translocation pore; other site
1049565011803	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460
1049565011804	RNA polymerase sigma factor RpoS; Validated; Region: PRK05657
1049565011805	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1049565011806	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1049565011807	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1049565011808	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1049565011809	DNA binding residues [nucleotide binding]
1049565011810	lipoprotein NlpD; Provisional; Region: nlpD; PRK10871
1049565011811	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1049565011812	Peptidase family M23; Region: Peptidase_M23; pfam01551
1049565011813	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
1049565011814	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1049565011815	S-adenosylmethionine binding site [chemical binding]; other site
1049565011816	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
1049565011817	tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984
1049565011818	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
1049565011819	Permutation of conserved domain; other site
1049565011820	active site
1049565011821	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
1049565011822	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
1049565011823	homotrimer interaction site [polypeptide binding]; other site
1049565011824	zinc binding site [ion binding]; other site
1049565011825	CDP-binding sites; other site
1049565011826	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1049565011827	substrate binding site; other site
1049565011828	dimer interface; other site
1049565011829	cell division protein FtsB; Reviewed; Region: ftsB; PRK00888
1049565011830	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
1049565011831	Protein of unknown function (DUF3561); Region: DUF3561; pfam12084
1049565011832	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
1049565011833	ligand-binding site [chemical binding]; other site
1049565011834	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
1049565011835	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
1049565011836	CysD dimerization site [polypeptide binding]; other site
1049565011837	G1 box; other site
1049565011838	putative GEF interaction site [polypeptide binding]; other site
1049565011839	GTP/Mg2+ binding site [chemical binding]; other site
1049565011840	Switch I region; other site
1049565011841	G2 box; other site
1049565011842	G3 box; other site
1049565011843	Switch II region; other site
1049565011844	G4 box; other site
1049565011845	G5 box; other site
1049565011846	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
1049565011847	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
1049565011848	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
1049565011849	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1049565011850	Active Sites [active]
1049565011851	siroheme synthase; Provisional; Region: cysG; PRK10637
1049565011852	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
1049565011853	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
1049565011854	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1049565011855	active site
1049565011856	SAM binding site [chemical binding]; other site
1049565011857	homodimer interface [polypeptide binding]; other site
1049565011858	alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199
1049565011859	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
1049565011860	metal binding site [ion binding]; metal-binding site
1049565011861	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
1049565011862	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1049565011863	Active Sites [active]
1049565011864	sulfite reductase subunit beta; Provisional; Region: PRK13504
1049565011865	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1049565011866	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1049565011867	sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953
1049565011868	Flavodoxin; Region: Flavodoxin_1; pfam00258
1049565011869	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
1049565011870	FAD binding pocket [chemical binding]; other site
1049565011871	FAD binding motif [chemical binding]; other site
1049565011872	catalytic residues [active]
1049565011873	NAD binding pocket [chemical binding]; other site
1049565011874	phosphate binding motif [ion binding]; other site
1049565011875	beta-alpha-beta structure motif; other site
1049565011876	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
1049565011877	active site
1049565011878	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
1049565011879	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
1049565011880	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1049565011881	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1049565011882	NAD(P) binding site [chemical binding]; other site
1049565011883	active site
1049565011884	enolase; Provisional; Region: eno; PRK00077
1049565011885	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1049565011886	dimer interface [polypeptide binding]; other site
1049565011887	metal binding site [ion binding]; metal-binding site
1049565011888	substrate binding pocket [chemical binding]; other site
1049565011889	CTP synthetase; Validated; Region: pyrG; PRK05380
1049565011890	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1049565011891	Catalytic site [active]
1049565011892	active site
1049565011893	UTP binding site [chemical binding]; other site
1049565011894	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1049565011895	active site
1049565011896	putative oxyanion hole; other site
1049565011897	catalytic triad [active]
1049565011898	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
1049565011899	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
1049565011900	homodimer interface [polypeptide binding]; other site
1049565011901	metal binding site [ion binding]; metal-binding site
1049565011902	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
1049565011903	homodimer interface [polypeptide binding]; other site
1049565011904	active site
1049565011905	putative chemical substrate binding site [chemical binding]; other site
1049565011906	metal binding site [ion binding]; metal-binding site
1049565011907	(p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872
1049565011908	HD domain; Region: HD_4; pfam13328
1049565011909	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1049565011910	synthetase active site [active]
1049565011911	NTP binding site [chemical binding]; other site
1049565011912	metal binding site [ion binding]; metal-binding site
1049565011913	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1049565011914	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1049565011915	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
1049565011916	TRAM domain; Region: TRAM; pfam01938
1049565011917	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1049565011918	S-adenosylmethionine binding site [chemical binding]; other site
1049565011919	Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984
1049565011920	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1049565011921	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1049565011922	dimerization interface [polypeptide binding]; other site
1049565011923	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1049565011924	dimer interface [polypeptide binding]; other site
1049565011925	phosphorylation site [posttranslational modification]
1049565011926	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1049565011927	ATP binding site [chemical binding]; other site
1049565011928	Mg2+ binding site [ion binding]; other site
1049565011929	G-X-G motif; other site
1049565011930	Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999
1049565011931	Response regulator receiver domain; Region: Response_reg; pfam00072
1049565011932	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1049565011933	active site
1049565011934	phosphorylation site [posttranslational modification]
1049565011935	intermolecular recognition site; other site
1049565011936	dimerization interface [polypeptide binding]; other site
1049565011937	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1049565011938	putative binding surface; other site
1049565011939	active site
1049565011940	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
1049565011941	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
1049565011942	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
1049565011943	active site
1049565011944	tetramer interface [polypeptide binding]; other site
1049565011945	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
1049565011946	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
1049565011947	active site
1049565011948	tetramer interface [polypeptide binding]; other site
1049565011949	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565011950	D-galactonate transporter; Region: 2A0114; TIGR00893
1049565011951	putative substrate translocation pore; other site
1049565011952	flavodoxin; Provisional; Region: PRK08105
1049565011953	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1049565011954	tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563
1049565011955	probable active site [active]
1049565011956	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098
1049565011957	SecY interacting protein Syd; Provisional; Region: PRK04968
1049565011958	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
1049565011959	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
1049565011960	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
1049565011961	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
1049565011962	Domain of unknown function (DUF3412); Region: DUF3412; pfam11892
1049565011963	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
1049565011964	serine transporter; Region: stp; TIGR00814
1049565011965	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
1049565011966	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1049565011967	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
1049565011968	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1049565011969	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1049565011970	substrate binding pocket [chemical binding]; other site
1049565011971	membrane-bound complex binding site; other site
1049565011972	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
1049565011973	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
1049565011974	Flavin binding site [chemical binding]; other site
1049565011975	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565011976	putative substrate translocation pore; other site
1049565011977	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
1049565011978	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565011979	NLPA lipoprotein; Region: Lipoprotein_9; cl17547
1049565011980	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565011981	dimer interface [polypeptide binding]; other site
1049565011982	conserved gate region; other site
1049565011983	ABC-ATPase subunit interface; other site
1049565011984	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
1049565011985	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1049565011986	Walker A/P-loop; other site
1049565011987	ATP binding site [chemical binding]; other site
1049565011988	Q-loop/lid; other site
1049565011989	ABC transporter signature motif; other site
1049565011990	Walker B; other site
1049565011991	D-loop; other site
1049565011992	H-loop/switch region; other site
1049565011993	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1049565011994	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1049565011995	active site
1049565011996	non-prolyl cis peptide bond; other site
1049565011997	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
1049565011998	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
1049565011999	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
1049565012000	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
1049565012001	active site
1049565012002	dimer interface [polypeptide binding]; other site
1049565012003	non-prolyl cis peptide bond; other site
1049565012004	insertion regions; other site
1049565012005	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
1049565012006	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1049565012007	Walker A motif; other site
1049565012008	ATP binding site [chemical binding]; other site
1049565012009	Walker B motif; other site
1049565012010	arginine finger; other site
1049565012011	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1049565012012	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1049565012013	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1049565012014	substrate binding pocket [chemical binding]; other site
1049565012015	membrane-bound complex binding site; other site
1049565012016	hinge residues; other site
1049565012017	flap endonuclease-like protein; Provisional; Region: PRK09482
1049565012018	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1049565012019	active site
1049565012020	metal binding site 1 [ion binding]; metal-binding site
1049565012021	putative 5' ssDNA interaction site; other site
1049565012022	metal binding site 3; metal-binding site
1049565012023	metal binding site 2 [ion binding]; metal-binding site
1049565012024	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1049565012025	putative DNA binding site [nucleotide binding]; other site
1049565012026	putative metal binding site [ion binding]; other site
1049565012027	L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624
1049565012028	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
1049565012029	dimer interface [polypeptide binding]; other site
1049565012030	active site
1049565012031	metal binding site [ion binding]; metal-binding site
1049565012032	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
1049565012033	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
1049565012034	intersubunit interface [polypeptide binding]; other site
1049565012035	active site
1049565012036	Zn2+ binding site [ion binding]; other site
1049565012037	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
1049565012038	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565012039	putative substrate translocation pore; other site
1049565012040	L-fucose isomerase; Provisional; Region: fucI; PRK10991
1049565012041	L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556
1049565012042	hexamer (dimer of trimers) interface [polypeptide binding]; other site
1049565012043	trimer interface [polypeptide binding]; other site
1049565012044	substrate binding site [chemical binding]; other site
1049565012045	Mn binding site [ion binding]; other site
1049565012046	L-fuculokinase; Provisional; Region: PRK10331
1049565012047	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1049565012048	nucleotide binding site [chemical binding]; other site
1049565012049	L-fucose mutarotase; Provisional; Region: fucU; PRK15420
1049565012050	DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411
1049565012051	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1049565012052	DNA-binding site [nucleotide binding]; DNA binding site
1049565012053	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1049565012054	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
1049565012055	FtsJ-like methyltransferase; Region: FtsJ; cl17430
1049565012056	hypothetical protein; Provisional; Region: PRK10873
1049565012057	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1049565012058	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565012059	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1049565012060	dimerization interface [polypeptide binding]; other site
1049565012061	substrate binding pocket [chemical binding]; other site
1049565012062	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
1049565012063	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1049565012064	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1049565012065	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1049565012066	catalytic residue [active]
1049565012067	Fe-S metabolism associated domain; Region: SufE; cl00951
1049565012068	sulfur acceptor protein CsdL; Provisional; Region: PRK15116
1049565012069	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
1049565012070	putative ATP binding site [chemical binding]; other site
1049565012071	putative substrate interface [chemical binding]; other site
1049565012072	murein transglycosylase A; Provisional; Region: mltA; PRK11162
1049565012073	MltA specific insert domain; Region: MltA; pfam03562
1049565012074	3D domain; Region: 3D; pfam06725
1049565012075	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
1049565012076	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
1049565012077	putative dimer interface [polypeptide binding]; other site
1049565012078	active site pocket [active]
1049565012079	putative cataytic base [active]
1049565012080	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
1049565012081	homotrimer interface [polypeptide binding]; other site
1049565012082	Walker A motif; other site
1049565012083	GTP binding site [chemical binding]; other site
1049565012084	Walker B motif; other site
1049565012085	cobyric acid synthase; Provisional; Region: PRK00784
1049565012086	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1049565012087	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1049565012088	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
1049565012089	catalytic triad [active]
1049565012090	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638
1049565012091	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1049565012092	Walker A/P-loop; other site
1049565012093	ATP binding site [chemical binding]; other site
1049565012094	Q-loop/lid; other site
1049565012095	ABC transporter signature motif; other site
1049565012096	Walker B; other site
1049565012097	D-loop; other site
1049565012098	H-loop/switch region; other site
1049565012099	cobalt transport protein CbiQ; Provisional; Region: PRK15485
1049565012100	cobalt transport protein CbiN; Provisional; Region: PRK02898
1049565012101	cobalt transport protein CbiM; Validated; Region: PRK08319
1049565012102	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
1049565012103	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
1049565012104	active site
1049565012105	SAM binding site [chemical binding]; other site
1049565012106	homodimer interface [polypeptide binding]; other site
1049565012107	Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822
1049565012108	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412
1049565012109	active site
1049565012110	C-terminal domain interface [polypeptide binding]; other site
1049565012111	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413
1049565012112	active site
1049565012113	N-terminal domain interface [polypeptide binding]; other site
1049565012114	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
1049565012115	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
1049565012116	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
1049565012117	active site
1049565012118	SAM binding site [chemical binding]; other site
1049565012119	homodimer interface [polypeptide binding]; other site
1049565012120	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
1049565012121	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
1049565012122	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
1049565012123	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
1049565012124	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
1049565012125	active site
1049565012126	SAM binding site [chemical binding]; other site
1049565012127	homodimer interface [polypeptide binding]; other site
1049565012128	cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287
1049565012129	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1049565012130	S-adenosylmethionine binding site [chemical binding]; other site
1049565012131	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
1049565012132	active site
1049565012133	putative homodimer interface [polypeptide binding]; other site
1049565012134	SAM binding site [chemical binding]; other site
1049565012135	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
1049565012136	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286
1049565012137	Precorrin-8X methylmutase; Region: CbiC; pfam02570
1049565012138	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
1049565012139	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
1049565012140	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
1049565012141	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
1049565012142	catalytic triad [active]
1049565012143	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
1049565012144	Sensory domain found in PocR; Region: PocR; pfam10114
1049565012145	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1049565012146	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565012147	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565012148	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
1049565012149	amphipathic channel; other site
1049565012150	Asn-Pro-Ala signature motifs; other site
1049565012151	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
1049565012152	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
1049565012153	Hexamer interface [polypeptide binding]; other site
1049565012154	Putative hexagonal pore residue; other site
1049565012155	propanediol utilization protein PduB; Provisional; Region: PRK15415
1049565012156	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047
1049565012157	putative hexamer interface [polypeptide binding]; other site
1049565012158	putative hexagonal pore; other site
1049565012159	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048
1049565012160	putative hexamer interface [polypeptide binding]; other site
1049565012161	putative hexagonal pore; other site
1049565012162	Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909
1049565012163	Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687
1049565012164	alpha-alpha subunit/dimer interface [polypeptide binding]; other site
1049565012165	alpha-beta subunit interface [polypeptide binding]; other site
1049565012166	alpha-gamma subunit interface [polypeptide binding]; other site
1049565012167	active site
1049565012168	substrate and K+ binding site; other site
1049565012169	K+ binding site [ion binding]; other site
1049565012170	cobalamin binding site [chemical binding]; other site
1049565012171	propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042
1049565012172	Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910
1049565012173	Cell division protein FtsA; Region: FtsA; cl17206
1049565012174	Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841
1049565012175	Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288
1049565012176	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
1049565012177	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
1049565012178	Hexamer interface [polypeptide binding]; other site
1049565012179	Putative hexagonal pore residue; other site
1049565012180	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
1049565012181	Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982
1049565012182	Hexamer interface [polypeptide binding]; other site
1049565012183	Hexagonal pore residue; other site
1049565012184	propanediol utilization phosphotransacylase; Provisional; Region: PRK15070
1049565012185	Propanediol utilisation protein PduL; Region: PduL; pfam06130
1049565012186	Propanediol utilisation protein PduL; Region: PduL; pfam06130
1049565012187	putative propanediol utilization protein PduM; Provisional; Region: PRK15428
1049565012188	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
1049565012189	Hexamer/Pentamer interface [polypeptide binding]; other site
1049565012190	central pore; other site
1049565012191	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
1049565012192	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
1049565012193	Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121
1049565012194	putative catalytic cysteine [active]
1049565012195	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1049565012196	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
1049565012197	active site
1049565012198	NAD binding site [chemical binding]; other site
1049565012199	metal binding site [ion binding]; metal-binding site
1049565012200	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
1049565012201	SLBB domain; Region: SLBB; pfam10531
1049565012202	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
1049565012203	RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375
1049565012204	PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526
1049565012205	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053
1049565012206	putative hexamer interface [polypeptide binding]; other site
1049565012207	putative hexagonal pore; other site
1049565012208	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054
1049565012209	putative hexamer interface [polypeptide binding]; other site
1049565012210	putative hexagonal pore; other site
1049565012211	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
1049565012212	putative hexamer interface [polypeptide binding]; other site
1049565012213	putative hexagonal pore; other site
1049565012214	Ethanolamine utilisation - propanediol utilisation; Region: PduV-EutP; pfam10662
1049565012215	G3 box; other site
1049565012216	Switch II region; other site
1049565012217	GTP/Mg2+ binding site [chemical binding]; other site
1049565012218	G4 box; other site
1049565012219	G5 box; other site
1049565012220	propionate kinase; Reviewed; Region: PRK12397
1049565012221	propionate/acetate kinase; Provisional; Region: PRK12379
1049565012222	Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542
1049565012223	threonine-phosphate decarboxylase; Provisional; Region: PRK08056
1049565012224	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1049565012225	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565012226	homodimer interface [polypeptide binding]; other site
1049565012227	catalytic residue [active]
1049565012228	AMIN domain; Region: AMIN; pfam11741
1049565012229	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1049565012230	active site
1049565012231	metal binding site [ion binding]; metal-binding site
1049565012232	N-acetylglutamate synthase; Validated; Region: PRK05279
1049565012233	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
1049565012234	putative feedback inhibition sensing region; other site
1049565012235	putative nucleotide binding site [chemical binding]; other site
1049565012236	putative substrate binding site [chemical binding]; other site
1049565012237	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1049565012238	Coenzyme A binding pocket [chemical binding]; other site
1049565012239	exonuclease V subunit alpha; Provisional; Region: recD; PRK10875
1049565012240	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
1049565012241	Family description; Region: UvrD_C_2; pfam13538
1049565012242	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
1049565012243	protease3; Provisional; Region: PRK15101
1049565012244	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1049565012245	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1049565012246	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1049565012247	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
1049565012248	Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330
1049565012249	hypothetical protein; Provisional; Region: PRK10332
1049565012250	Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528
1049565012251	hypothetical protein; Provisional; Region: PRK11521
1049565012252	hypothetical protein; Provisional; Region: PRK10557
1049565012253	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
1049565012254	hypothetical protein; Provisional; Region: PRK10506
1049565012255	thymidylate synthase; Reviewed; Region: thyA; PRK01827
1049565012256	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1049565012257	dimerization interface [polypeptide binding]; other site
1049565012258	active site
1049565012259	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
1049565012260	fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061
1049565012261	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1049565012262	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1049565012263	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1049565012264	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1049565012265	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
1049565012266	putative active site [active]
1049565012267	Ap4A binding site [chemical binding]; other site
1049565012268	nudix motif; other site
1049565012269	putative metal binding site [ion binding]; other site
1049565012270	MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex.   MutH...; Region: MutH_Sau3AI; cd00583
1049565012271	putative DNA-binding cleft [nucleotide binding]; other site
1049565012272	putative DNA clevage site; other site
1049565012273	molecular lever; other site
1049565012274	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
1049565012275	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
1049565012276	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1049565012277	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1049565012278	active site
1049565012279	catalytic tetrad [active]
1049565012280	lysophospholipid transporter LplT; Provisional; Region: PRK11195
1049565012281	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565012282	putative substrate translocation pore; other site
1049565012283	bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043
1049565012284	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1049565012285	putative acyl-acceptor binding pocket; other site
1049565012286	C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909
1049565012287	acyl-activating enzyme (AAE) consensus motif; other site
1049565012288	putative AMP binding site [chemical binding]; other site
1049565012289	DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727
1049565012290	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1049565012291	DNA binding site [nucleotide binding]
1049565012292	domain linker motif; other site
1049565012293	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
1049565012294	dimerization interface (closed form) [polypeptide binding]; other site
1049565012295	ligand binding site [chemical binding]; other site
1049565012296	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1049565012297	Coenzyme A binding pocket [chemical binding]; other site
1049565012298	DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225
1049565012299	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1049565012300	DNA-binding site [nucleotide binding]; DNA binding site
1049565012301	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1049565012302	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
1049565012303	beta-galactosidase; Region: BGL; TIGR03356
1049565012304	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1049565012305	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1049565012306	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1049565012307	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1049565012308	DNA binding site [nucleotide binding]
1049565012309	domain linker motif; other site
1049565012310	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
1049565012311	dimerization interface (closed form) [polypeptide binding]; other site
1049565012312	ligand binding site [chemical binding]; other site
1049565012313	diaminopimelate decarboxylase; Provisional; Region: PRK11165
1049565012314	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1049565012315	active site
1049565012316	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1049565012317	substrate binding site [chemical binding]; other site
1049565012318	catalytic residues [active]
1049565012319	dimer interface [polypeptide binding]; other site
1049565012320	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
1049565012321	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565012322	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1049565012323	dimerization interface [polypeptide binding]; other site
1049565012324	putative racemase; Provisional; Region: PRK10200
1049565012325	aspartate racemase; Region: asp_race; TIGR00035
1049565012326	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
1049565012327	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565012328	dimer interface [polypeptide binding]; other site
1049565012329	conserved gate region; other site
1049565012330	putative PBP binding loops; other site
1049565012331	ABC-ATPase subunit interface; other site
1049565012332	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1049565012333	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565012334	dimer interface [polypeptide binding]; other site
1049565012335	conserved gate region; other site
1049565012336	putative PBP binding loops; other site
1049565012337	ABC-ATPase subunit interface; other site
1049565012338	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1049565012339	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1049565012340	Walker A/P-loop; other site
1049565012341	ATP binding site [chemical binding]; other site
1049565012342	Q-loop/lid; other site
1049565012343	ABC transporter signature motif; other site
1049565012344	Walker B; other site
1049565012345	D-loop; other site
1049565012346	H-loop/switch region; other site
1049565012347	TOBE domain; Region: TOBE; pfam03459
1049565012348	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1049565012349	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1049565012350	Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471
1049565012351	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
1049565012352	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1049565012353	substrate binding [chemical binding]; other site
1049565012354	active site
1049565012355	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1049565012356	galactoside permease; Reviewed; Region: lacY; PRK09528
1049565012357	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565012358	putative substrate translocation pore; other site
1049565012359	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1049565012360	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1049565012361	DNA binding site [nucleotide binding]
1049565012362	domain linker motif; other site
1049565012363	Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288
1049565012364	putative dimerization interface [polypeptide binding]; other site
1049565012365	putative ligand binding site [chemical binding]; other site
1049565012366	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
1049565012367	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565012368	putative substrate translocation pore; other site
1049565012369	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565012370	2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993
1049565012371	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
1049565012372	NADP binding site [chemical binding]; other site
1049565012373	homodimer interface [polypeptide binding]; other site
1049565012374	active site
1049565012375	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
1049565012376	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1049565012377	Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629
1049565012378	putative acyltransferase; Provisional; Region: PRK05790
1049565012379	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1049565012380	dimer interface [polypeptide binding]; other site
1049565012381	active site
1049565012382	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565012383	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565012384	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1049565012385	dimerization interface [polypeptide binding]; other site
1049565012386	Predicted membrane protein [Function unknown]; Region: COG4125
1049565012387	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
1049565012388	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
1049565012389	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
1049565012390	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
1049565012391	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1049565012392	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1049565012393	active site
1049565012394	catalytic tetrad [active]
1049565012395	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
1049565012396	PilZ domain; Region: PilZ; pfam07238
1049565012397	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1049565012398	DNA binding residues [nucleotide binding]
1049565012399	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1049565012400	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
1049565012401	putative major fimbrial protein SthE; Provisional; Region: PRK15292
1049565012402	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
1049565012403	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
1049565012404	PapC N-terminal domain; Region: PapC_N; pfam13954
1049565012405	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
1049565012406	PapC C-terminal domain; Region: PapC_C; pfam13953
1049565012407	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
1049565012408	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
1049565012409	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
1049565012410	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
1049565012411	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
1049565012412	EamA-like transporter family; Region: EamA; pfam00892
1049565012413	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1049565012414	EamA-like transporter family; Region: EamA; pfam00892
1049565012415	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1049565012416	MarR family; Region: MarR; pfam01047
1049565012417	MarR family; Region: MarR_2; cl17246
1049565012418	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215
1049565012419	FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197
1049565012420	Int/Topo IB signature motif; other site
1049565012421	tyrosine recombinase; Provisional; Region: PRK09871
1049565012422	active site
1049565012423	DNA binding site [nucleotide binding]
1049565012424	Int/Topo IB signature motif; other site
1049565012425	Fimbrial protein; Region: Fimbrial; cl01416
1049565012426	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
1049565012427	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
1049565012428	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
1049565012429	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
1049565012430	outer membrane usher protein; Provisional; Region: PRK15193
1049565012431	PapC N-terminal domain; Region: PapC_N; pfam13954
1049565012432	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
1049565012433	PapC C-terminal domain; Region: PapC_C; pfam13953
1049565012434	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
1049565012435	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
1049565012436	Mannose binding  domain of FimH and related proteins; Region: FimH_man-bind; cd10466
1049565012437	mannosyl binding site [chemical binding]; other site
1049565012438	Fimbrial protein; Region: Fimbrial; cl01416
1049565012439	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
1049565012440	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1049565012441	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1049565012442	Coenzyme A binding pocket [chemical binding]; other site
1049565012443	Uncharacterized conserved protein [Function unknown]; Region: COG3592
1049565012444	multidrug resistance protein MdtN; Provisional; Region: PRK10476
1049565012445	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1049565012446	HlyD family secretion protein; Region: HlyD_3; pfam13437
1049565012447	multidrug efflux system protein MdtO; Provisional; Region: PRK11427
1049565012448	putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915
1049565012449	Domain of unknown function (DUF1889); Region: DUF1889; pfam08986
1049565012450	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565012451	putative substrate translocation pore; other site
1049565012452	POT family; Region: PTR2; cl17359
1049565012453	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
1049565012454	ArsC family; Region: ArsC; pfam03960
1049565012455	catalytic residues [active]
1049565012456	arsenical pump membrane protein; Provisional; Region: PRK15445
1049565012457	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
1049565012458	transmembrane helices; other site
1049565012459	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1049565012460	dimerization interface [polypeptide binding]; other site
1049565012461	putative DNA binding site [nucleotide binding]; other site
1049565012462	putative Zn2+ binding site [ion binding]; other site
1049565012463	YCII-related domain; Region: YCII; cl00999
1049565012464	Protein of unknown function (DUF1349); Region: DUF1349; pfam07081
1049565012465	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565012466	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565012467	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1049565012468	dimerization interface [polypeptide binding]; other site
1049565012469	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
1049565012470	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1049565012471	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1049565012472	active site
1049565012473	catalytic tetrad [active]
1049565012474	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
1049565012475	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
1049565012476	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1049565012477	active site
1049565012478	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1049565012479	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
1049565012480	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
1049565012481	camphor resistance protein CrcB; Provisional; Region: ccrB; PRK01636
1049565012482	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
1049565012483	phosphorylation site [posttranslational modification]
1049565012484	dimer interface [polypeptide binding]; other site
1049565012485	Response regulator receiver domain; Region: Response_reg; pfam00072
1049565012486	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1049565012487	active site
1049565012488	phosphorylation site [posttranslational modification]
1049565012489	intermolecular recognition site; other site
1049565012490	dimerization interface [polypeptide binding]; other site
1049565012491	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1049565012492	putative binding surface; other site
1049565012493	active site
1049565012494	DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958
1049565012495	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1049565012496	active site
1049565012497	phosphorylation site [posttranslational modification]
1049565012498	intermolecular recognition site; other site
1049565012499	dimerization interface [polypeptide binding]; other site
1049565012500	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1049565012501	DNA binding residues [nucleotide binding]
1049565012502	dimerization interface [polypeptide binding]; other site
1049565012503	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
1049565012504	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1049565012505	HlyD family secretion protein; Region: HlyD_3; pfam13437
1049565012506	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1049565012507	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565012508	acid-resistance membrane protein; Provisional; Region: PRK10209
1049565012509	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
1049565012510	HdeA/HdeB family; Region: HdeA; cl05752
1049565012511	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1049565012512	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
1049565012513	alpha-gamma subunit interface [polypeptide binding]; other site
1049565012514	beta-gamma subunit interface [polypeptide binding]; other site
1049565012515	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
1049565012516	alpha-beta subunit interface [polypeptide binding]; other site
1049565012517	urease subunit alpha; Reviewed; Region: ureC; PRK13309
1049565012518	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
1049565012519	subunit interactions [polypeptide binding]; other site
1049565012520	active site
1049565012521	flap region; other site
1049565012522	urease accessory protein UreE; Provisional; Region: ureE; PRK14711
1049565012523	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
1049565012524	UreE urease accessory protein, C-terminal domain; Region: UreE_C; pfam05194
1049565012525	dimer interface [polypeptide binding]; other site
1049565012526	catalytic residues [active]
1049565012527	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
1049565012528	UreF; Region: UreF; pfam01730
1049565012529	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1049565012530	UreD urease accessory protein; Region: UreD; cl00530
1049565012531	urea transporter, Yersinia type; Region: urea_trans_yut; TIGR03441
1049565012532	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518
1049565012533	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1049565012534	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
1049565012535	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565012536	dimer interface [polypeptide binding]; other site
1049565012537	conserved gate region; other site
1049565012538	putative PBP binding loops; other site
1049565012539	ABC-ATPase subunit interface; other site
1049565012540	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1049565012541	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565012542	putative PBP binding loops; other site
1049565012543	ABC-ATPase subunit interface; other site
1049565012544	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1049565012545	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
1049565012546	Walker A/P-loop; other site
1049565012547	ATP binding site [chemical binding]; other site
1049565012548	Q-loop/lid; other site
1049565012549	ABC transporter signature motif; other site
1049565012550	Walker B; other site
1049565012551	D-loop; other site
1049565012552	H-loop/switch region; other site
1049565012553	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1049565012554	phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324
1049565012555	Walker A/P-loop; other site
1049565012556	ATP binding site [chemical binding]; other site
1049565012557	Q-loop/lid; other site
1049565012558	ABC transporter signature motif; other site
1049565012559	Walker B; other site
1049565012560	D-loop; other site
1049565012561	H-loop/switch region; other site
1049565012562	HdeA/HdeB family; Region: HdeA; cl05752
1049565012563	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1049565012564	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1049565012565	TPR motif; other site
1049565012566	binding surface
1049565012567	Sel1-like repeats; Region: SEL1; smart00671
1049565012568	Sel1-like repeats; Region: SEL1; smart00671
1049565012569	Sel1-like repeats; Region: SEL1; smart00671
1049565012570	PapC C-terminal domain; Region: PapC_C; pfam13953
1049565012571	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
1049565012572	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
1049565012573	DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958
1049565012574	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1049565012575	active site
1049565012576	phosphorylation site [posttranslational modification]
1049565012577	intermolecular recognition site; other site
1049565012578	dimerization interface [polypeptide binding]; other site
1049565012579	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1049565012580	DNA binding residues [nucleotide binding]
1049565012581	dimerization interface [polypeptide binding]; other site
1049565012582	hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959
1049565012583	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1049565012584	substrate binding pocket [chemical binding]; other site
1049565012585	membrane-bound complex binding site; other site
1049565012586	hinge residues; other site
1049565012587	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1049565012588	substrate binding pocket [chemical binding]; other site
1049565012589	membrane-bound complex binding site; other site
1049565012590	hinge residues; other site
1049565012591	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1049565012592	dimer interface [polypeptide binding]; other site
1049565012593	phosphorylation site [posttranslational modification]
1049565012594	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1049565012595	ATP binding site [chemical binding]; other site
1049565012596	Mg2+ binding site [ion binding]; other site
1049565012597	G-X-G motif; other site
1049565012598	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1049565012599	active site
1049565012600	phosphorylation site [posttranslational modification]
1049565012601	intermolecular recognition site; other site
1049565012602	dimerization interface [polypeptide binding]; other site
1049565012603	Hpt domain; Region: Hpt; pfam01627
1049565012604	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1049565012605	DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958
1049565012606	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1049565012607	active site
1049565012608	phosphorylation site [posttranslational modification]
1049565012609	intermolecular recognition site; other site
1049565012610	dimerization interface [polypeptide binding]; other site
1049565012611	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1049565012612	DNA binding residues [nucleotide binding]
1049565012613	dimerization interface [polypeptide binding]; other site
1049565012614	Secretory lipase; Region: LIP; pfam03583
1049565012615	Integrase core domain; Region: rve; pfam00665
1049565012616	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565012617	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565012618	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460
1049565012619	putative substrate binding pocket [chemical binding]; other site
1049565012620	putative dimerization interface [polypeptide binding]; other site
1049565012621	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565012622	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1049565012623	putative substrate translocation pore; other site
1049565012624	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1049565012625	Peptidase family M23; Region: Peptidase_M23; pfam01551
1049565012626	Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443
1049565012627	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
1049565012628	active site
1049565012629	metal binding site [ion binding]; metal-binding site
1049565012630	nudix motif; other site
1049565012631	lysyl-tRNA synthetase; Reviewed; Region: PRK12445
1049565012632	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1049565012633	dimer interface [polypeptide binding]; other site
1049565012634	putative anticodon binding site; other site
1049565012635	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
1049565012636	motif 1; other site
1049565012637	active site
1049565012638	motif 2; other site
1049565012639	motif 3; other site
1049565012640	peptide chain release factor 2; Provisional; Region: PRK08787
1049565012641	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1049565012642	RF-1 domain; Region: RF-1; pfam00472
1049565012643	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
1049565012644	DHH family; Region: DHH; pfam01368
1049565012645	DHHA1 domain; Region: DHHA1; pfam02272
1049565012646	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
1049565012647	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
1049565012648	dimerization domain [polypeptide binding]; other site
1049565012649	dimer interface [polypeptide binding]; other site
1049565012650	catalytic residues [active]
1049565012651	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
1049565012652	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
1049565012653	active site
1049565012654	Int/Topo IB signature motif; other site
1049565012655	flavodoxin FldB; Provisional; Region: PRK12359
1049565012656	Protein of unknown function (DUF1434); Region: DUF1434; pfam07254
1049565012657	hypothetical protein; Provisional; Region: PRK10878
1049565012658	putative global regulator; Reviewed; Region: PRK09559
1049565012659	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
1049565012660	hemolysin; Provisional; Region: PRK15087
1049565012661	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
1049565012662	ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552
1049565012663	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1049565012664	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1049565012665	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1049565012666	putative active site [active]
1049565012667	6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014
1049565012668	beta-galactosidase; Region: BGL; TIGR03356
1049565012669	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
1049565012670	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1049565012671	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
1049565012672	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
1049565012673	DsbD alpha interface [polypeptide binding]; other site
1049565012674	catalytic residues [active]
1049565012675	conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283
1049565012676	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
1049565012677	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1049565012678	catalytic residues [active]
1049565012679	TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011
1049565012680	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1049565012681	catalytic residues [active]
1049565012682	putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730
1049565012683	classical (c) SDRs; Region: SDR_c; cd05233
1049565012684	NAD(P) binding site [chemical binding]; other site
1049565012685	active site
1049565012686	glycine dehydrogenase; Provisional; Region: PRK05367
1049565012687	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1049565012688	tetramer interface [polypeptide binding]; other site
1049565012689	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565012690	catalytic residue [active]
1049565012691	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1049565012692	tetramer interface [polypeptide binding]; other site
1049565012693	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565012694	catalytic residue [active]
1049565012695	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1049565012696	lipoyl attachment site [posttranslational modification]; other site
1049565012697	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
1049565012698	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1049565012699	oxidoreductase; Provisional; Region: PRK08013
1049565012700	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
1049565012701	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732
1049565012702	2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984
1049565012703	proline aminopeptidase P II; Provisional; Region: PRK10879
1049565012704	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
1049565012705	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
1049565012706	active site
1049565012707	hypothetical protein; Reviewed; Region: PRK01736
1049565012708	Z-ring-associated protein; Provisional; Region: PRK10972
1049565012709	5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333
1049565012710	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
1049565012711	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
1049565012712	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
1049565012713	ligand binding site [chemical binding]; other site
1049565012714	NAD binding site [chemical binding]; other site
1049565012715	tetramer interface [polypeptide binding]; other site
1049565012716	catalytic site [active]
1049565012717	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
1049565012718	L-serine binding site [chemical binding]; other site
1049565012719	ACT domain interface; other site
1049565012720	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
1049565012721	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1049565012722	active site
1049565012723	dimer interface [polypeptide binding]; other site
1049565012724	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
1049565012725	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565012726	The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428
1049565012727	putative dimerization interface [polypeptide binding]; other site
1049565012728	oxidative stress defense protein; Provisional; Region: PRK11087
1049565012729	Uncharacterized conserved protein [Function unknown]; Region: COG2968
1049565012730	arginine exporter protein; Provisional; Region: PRK09304
1049565012731	mechanosensitive channel MscS; Provisional; Region: PRK10334
1049565012732	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1049565012733	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1049565012734	Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946
1049565012735	active site
1049565012736	intersubunit interface [polypeptide binding]; other site
1049565012737	zinc binding site [ion binding]; other site
1049565012738	Na+ binding site [ion binding]; other site
1049565012739	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
1049565012740	Phosphoglycerate kinase; Region: PGK; pfam00162
1049565012741	substrate binding site [chemical binding]; other site
1049565012742	hinge regions; other site
1049565012743	ADP binding site [chemical binding]; other site
1049565012744	catalytic site [active]
1049565012745	erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535
1049565012746	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1049565012747	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1049565012748	transketolase; Reviewed; Region: PRK12753
1049565012749	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1049565012750	TPP-binding site [chemical binding]; other site
1049565012751	dimer interface [polypeptide binding]; other site
1049565012752	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1049565012753	PYR/PP interface [polypeptide binding]; other site
1049565012754	dimer interface [polypeptide binding]; other site
1049565012755	TPP binding site [chemical binding]; other site
1049565012756	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1049565012757	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
1049565012758	outer membrane porin, OprD family; Region: OprD; pfam03573
1049565012759	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
1049565012760	agmatinase; Region: agmatinase; TIGR01230
1049565012761	oligomer interface [polypeptide binding]; other site
1049565012762	putative active site [active]
1049565012763	Mn binding site [ion binding]; other site
1049565012764	Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166
1049565012765	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
1049565012766	dimer interface [polypeptide binding]; other site
1049565012767	active site
1049565012768	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1049565012769	catalytic residues [active]
1049565012770	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
1049565012771	Virulence promoting factor; Region: YqgB; pfam11036
1049565012772	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1049565012773	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1049565012774	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1049565012775	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1049565012776	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
1049565012777	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565012778	putative substrate translocation pore; other site
1049565012779	Bacterial protein of unknown function (DUF899); Region: DUF899; cl17828
1049565012780	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565012781	hypothetical protein; Provisional; Region: PRK04860
1049565012782	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
1049565012783	potential frameshift: common BLAST hit: gi|238896475|ref|YP_002921213.1| DNA-specific endonuclease I
1049565012784	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
1049565012785	RNA methyltransferase, RsmE family; Region: TIGR00046
1049565012786	glutathione synthetase; Provisional; Region: PRK05246
1049565012787	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
1049565012788	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
1049565012789	hypothetical protein; Validated; Region: PRK00228
1049565012790	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
1049565012791	DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100
1049565012792	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1049565012793	DNA binding residues [nucleotide binding]
1049565012794	dimerization interface [polypeptide binding]; other site
1049565012795	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
1049565012796	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
1049565012797	Walker A motif; other site
1049565012798	ATP binding site [chemical binding]; other site
1049565012799	Walker B motif; other site
1049565012800	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
1049565012801	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1049565012802	catalytic residue [active]
1049565012803	YGGT family; Region: YGGT; pfam02325
1049565012804	YGGT family; Region: YGGT; pfam02325
1049565012805	hypothetical protein; Validated; Region: PRK05090
1049565012806	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1049565012807	active site
1049565012808	dimerization interface [polypeptide binding]; other site
1049565012809	HemN family oxidoreductase; Provisional; Region: PRK05660
1049565012810	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1049565012811	FeS/SAM binding site; other site
1049565012812	HemN C-terminal domain; Region: HemN_C; pfam06969
1049565012813	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
1049565012814	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
1049565012815	putative ligand binding site [chemical binding]; other site
1049565012816	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1049565012817	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1049565012818	Walker A/P-loop; other site
1049565012819	ATP binding site [chemical binding]; other site
1049565012820	Q-loop/lid; other site
1049565012821	ABC transporter signature motif; other site
1049565012822	Walker B; other site
1049565012823	D-loop; other site
1049565012824	H-loop/switch region; other site
1049565012825	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
1049565012826	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1049565012827	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1049565012828	TM-ABC transporter signature motif; other site
1049565012829	hypothetical protein; Provisional; Region: PRK10626
1049565012830	Protein of unknown function (DUF2884); Region: DUF2884; pfam11101
1049565012831	hypothetical protein; Provisional; Region: PRK11702
1049565012832	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
1049565012833	adenine DNA glycosylase; Provisional; Region: PRK10880
1049565012834	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1049565012835	minor groove reading motif; other site
1049565012836	helix-hairpin-helix signature motif; other site
1049565012837	substrate binding pocket [chemical binding]; other site
1049565012838	active site
1049565012839	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
1049565012840	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
1049565012841	DNA binding and oxoG recognition site [nucleotide binding]
1049565012842	oxidative damage protection protein; Provisional; Region: PRK05408
1049565012843	murein transglycosylase C; Provisional; Region: mltC; PRK11671
1049565012844	Domain of unknown function (DUF3393); Region: DUF3393; pfam11873
1049565012845	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1049565012846	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1049565012847	catalytic residue [active]
1049565012848	nucleoside transporter; Region: 2A0110; TIGR00889
1049565012849	ornithine decarboxylase; Provisional; Region: PRK13578
1049565012850	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
1049565012851	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
1049565012852	homodimer interface [polypeptide binding]; other site
1049565012853	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565012854	catalytic residue [active]
1049565012855	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
1049565012856	Protein of unknown function (DUF554); Region: DUF554; pfam04474
1049565012857	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
1049565012858	active site
1049565012859	Int/Topo IB signature motif; other site
1049565012860	Integrase; Region: Integrase_1; pfam12835
1049565012861	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1049565012862	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1049565012863	putative active site [active]
1049565012864	putative NTP binding site [chemical binding]; other site
1049565012865	putative nucleic acid binding site [nucleotide binding]; other site
1049565012866	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
1049565012867	PapC N-terminal domain; Region: PapC_N; pfam13954
1049565012868	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
1049565012869	PapC C-terminal domain; Region: PapC_C; pfam13953
1049565012870	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
1049565012871	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
1049565012872	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
1049565012873	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
1049565012874	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
1049565012875	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
1049565012876	Fimbrial protein; Region: Fimbrial; pfam00419
1049565012877	Fimbrial protein; Region: Fimbrial; pfam00419
1049565012878	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
1049565012879	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
1049565012880	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
1049565012881	Fimbrial protein; Region: Fimbrial; cl01416
1049565012882	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1049565012883	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1049565012884	dimer interface [polypeptide binding]; other site
1049565012885	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565012886	catalytic residue [active]
1049565012887	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
1049565012888	FOG: CBS domain [General function prediction only]; Region: COG0517
1049565012889	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
1049565012890	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1049565012891	homodimer interface [polypeptide binding]; other site
1049565012892	substrate-cofactor binding pocket; other site
1049565012893	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565012894	catalytic residue [active]
1049565012895	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565012896	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565012897	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477
1049565012898	putative effector binding pocket; other site
1049565012899	putative dimerization interface [polypeptide binding]; other site
1049565012900	Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731
1049565012901	putative NAD(P) binding site [chemical binding]; other site
1049565012902	homodimer interface [polypeptide binding]; other site
1049565012903	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
1049565012904	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1049565012905	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565012906	homodimer interface [polypeptide binding]; other site
1049565012907	catalytic residue [active]
1049565012908	bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507
1049565012909	CHAP domain; Region: CHAP; pfam05257
1049565012910	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
1049565012911	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1049565012912	Thioredoxin; Region: Thioredoxin_4; cl17273
1049565012913	putative S-transferase; Provisional; Region: PRK11752
1049565012914	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
1049565012915	C-terminal domain interface [polypeptide binding]; other site
1049565012916	GSH binding site (G-site) [chemical binding]; other site
1049565012917	dimer interface [polypeptide binding]; other site
1049565012918	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
1049565012919	dimer interface [polypeptide binding]; other site
1049565012920	N-terminal domain interface [polypeptide binding]; other site
1049565012921	active site
1049565012922	Protein of unknown function (DUF2623); Region: DUF2623; pfam11115
1049565012923	potential frameshift: common BLAST hit: gi|152971938|ref|YP_001337047.1| putative enzyme
1049565012924	hypothetical protein; Provisional; Region: PRK05208
1049565012925	biopolymer transport protein ExbD; Provisional; Region: PRK11267
1049565012926	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1049565012927	biopolymer transport protein ExbB; Provisional; Region: PRK10414
1049565012928	cystathionine beta-lyase; Provisional; Region: PRK08114
1049565012929	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1049565012930	homodimer interface [polypeptide binding]; other site
1049565012931	substrate-cofactor binding pocket; other site
1049565012932	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565012933	catalytic residue [active]
1049565012934	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1049565012935	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1049565012936	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
1049565012937	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1049565012938	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565012939	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565012940	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
1049565012941	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
1049565012942	dimer interface [polypeptide binding]; other site
1049565012943	active site
1049565012944	metal binding site [ion binding]; metal-binding site
1049565012945	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1049565012946	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1049565012947	active site
1049565012948	catalytic tetrad [active]
1049565012949	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1049565012950	Coenzyme A binding pocket [chemical binding]; other site
1049565012951	hypothetical protein; Provisional; Region: PRK01254
1049565012952	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
1049565012953	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
1049565012954	FtsI repressor; Provisional; Region: PRK10883
1049565012955	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1049565012956	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
1049565012957	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1049565012958	putative acyl-acceptor binding pocket; other site
1049565012959	DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062
1049565012960	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1049565012961	CAP-like domain; other site
1049565012962	active site
1049565012963	primary dimer interface [polypeptide binding]; other site
1049565012964	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1049565012965	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565012966	DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449
1049565012967	Periplasmic protein with OB-fold [Function unknown]; Region: COG3111
1049565012968	DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336
1049565012969	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1049565012970	active site
1049565012971	phosphorylation site [posttranslational modification]
1049565012972	intermolecular recognition site; other site
1049565012973	dimerization interface [polypeptide binding]; other site
1049565012974	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1049565012975	DNA binding site [nucleotide binding]
1049565012976	sensor protein QseC; Provisional; Region: PRK10337
1049565012977	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1049565012978	dimer interface [polypeptide binding]; other site
1049565012979	phosphorylation site [posttranslational modification]
1049565012980	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1049565012981	ATP binding site [chemical binding]; other site
1049565012982	Mg2+ binding site [ion binding]; other site
1049565012983	G-X-G motif; other site
1049565012984	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
1049565012985	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1049565012986	DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055
1049565012987	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1049565012988	ATP binding site [chemical binding]; other site
1049565012989	Mg2+ binding site [ion binding]; other site
1049565012990	G-X-G motif; other site
1049565012991	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1049565012992	anchoring element; other site
1049565012993	dimer interface [polypeptide binding]; other site
1049565012994	ATP binding site [chemical binding]; other site
1049565012995	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
1049565012996	active site
1049565012997	metal binding site [ion binding]; metal-binding site
1049565012998	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1049565012999	esterase YqiA; Provisional; Region: PRK11071
1049565013000	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1049565013001	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
1049565013002	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1049565013003	active site
1049565013004	metal binding site [ion binding]; metal-binding site
1049565013005	hexamer interface [polypeptide binding]; other site
1049565013006	putative dehydrogenase; Provisional; Region: PRK11039
1049565013007	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
1049565013008	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1049565013009	dimer interface [polypeptide binding]; other site
1049565013010	ADP-ribose binding site [chemical binding]; other site
1049565013011	active site
1049565013012	nudix motif; other site
1049565013013	metal binding site [ion binding]; metal-binding site
1049565013014	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
1049565013015	hypothetical protein; Provisional; Region: PRK11653
1049565013016	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
1049565013017	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
1049565013018	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
1049565013019	putative active site [active]
1049565013020	metal binding site [ion binding]; metal-binding site
1049565013021	zinc transporter ZupT; Provisional; Region: PRK04201
1049565013022	ZIP Zinc transporter; Region: Zip; pfam02535
1049565013023	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353
1049565013024	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
1049565013025	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960
1049565013026	glycogen synthesis protein GlgS; Provisional; Region: PRK02922
1049565013027	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
1049565013028	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
1049565013029	putative ribose interaction site [chemical binding]; other site
1049565013030	putative ADP binding site [chemical binding]; other site
1049565013031	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
1049565013032	active site
1049565013033	nucleotide binding site [chemical binding]; other site
1049565013034	HIGH motif; other site
1049565013035	KMSKS motif; other site
1049565013036	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
1049565013037	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1049565013038	metal binding triad; other site
1049565013039	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1049565013040	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1049565013041	metal binding triad; other site
1049565013042	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1049565013043	Uncharacterized conserved protein [Function unknown]; Region: COG3025
1049565013044	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
1049565013045	putative active site [active]
1049565013046	putative metal binding residues [ion binding]; other site
1049565013047	signature motif; other site
1049565013048	putative triphosphate binding site [ion binding]; other site
1049565013049	SH3 domain-containing protein; Provisional; Region: PRK10884
1049565013050	Bacterial SH3 domain homologues; Region: SH3b; smart00287
1049565013051	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
1049565013052	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1049565013053	active site
1049565013054	NTP binding site [chemical binding]; other site
1049565013055	metal binding triad [ion binding]; metal-binding site
1049565013056	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1049565013057	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1049565013058	Zn2+ binding site [ion binding]; other site
1049565013059	Mg2+ binding site [ion binding]; other site
1049565013060	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
1049565013061	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
1049565013062	homooctamer interface [polypeptide binding]; other site
1049565013063	active site
1049565013064	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
1049565013065	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
1049565013066	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
1049565013067	alpha-gamma subunit interface [polypeptide binding]; other site
1049565013068	beta-gamma subunit interface [polypeptide binding]; other site
1049565013069	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
1049565013070	gamma-beta subunit interface [polypeptide binding]; other site
1049565013071	alpha-beta subunit interface [polypeptide binding]; other site
1049565013072	urease subunit alpha; Reviewed; Region: ureC; PRK13207
1049565013073	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
1049565013074	subunit interactions [polypeptide binding]; other site
1049565013075	active site
1049565013076	flap region; other site
1049565013077	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
1049565013078	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
1049565013079	dimer interface [polypeptide binding]; other site
1049565013080	catalytic residues [active]
1049565013081	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
1049565013082	UreF; Region: UreF; pfam01730
1049565013083	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1049565013084	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
1049565013085	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1049565013086	UGMP family protein; Validated; Region: PRK09604
1049565013087	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
1049565013088	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
1049565013089	DNA primase; Validated; Region: dnaG; PRK05667
1049565013090	CHC2 zinc finger; Region: zf-CHC2; pfam01807
1049565013091	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1049565013092	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1049565013093	active site
1049565013094	metal binding site [ion binding]; metal-binding site
1049565013095	interdomain interaction site; other site
1049565013096	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
1049565013097	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278
1049565013098	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
1049565013099	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
1049565013100	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1049565013101	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
1049565013102	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1049565013103	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1049565013104	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1049565013105	DNA binding residues [nucleotide binding]
1049565013106	G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028
1049565013107	active site
1049565013108	SUMO-1 interface [polypeptide binding]; other site
1049565013109	HdeA/HdeB family; Region: HdeA; pfam06411
1049565013110	DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958
1049565013111	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1049565013112	active site
1049565013113	phosphorylation site [posttranslational modification]
1049565013114	intermolecular recognition site; other site
1049565013115	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1049565013116	DNA binding residues [nucleotide binding]
1049565013117	dimerization interface [polypeptide binding]; other site
1049565013118	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
1049565013119	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1049565013120	substrate binding pocket [chemical binding]; other site
1049565013121	membrane-bound complex binding site; other site
1049565013122	hinge residues; other site
1049565013123	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
1049565013124	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1049565013125	substrate binding pocket [chemical binding]; other site
1049565013126	membrane-bound complex binding site; other site
1049565013127	hinge residues; other site
1049565013128	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1049565013129	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1049565013130	dimer interface [polypeptide binding]; other site
1049565013131	phosphorylation site [posttranslational modification]
1049565013132	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1049565013133	ATP binding site [chemical binding]; other site
1049565013134	Mg2+ binding site [ion binding]; other site
1049565013135	G-X-G motif; other site
1049565013136	Response regulator receiver domain; Region: Response_reg; pfam00072
1049565013137	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1049565013138	active site
1049565013139	phosphorylation site [posttranslational modification]
1049565013140	intermolecular recognition site; other site
1049565013141	dimerization interface [polypeptide binding]; other site
1049565013142	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
1049565013143	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
1049565013144	hypothetical protein; Provisional; Region: PRK10316
1049565013145	YfdX protein; Region: YfdX; pfam10938
1049565013146	acid-resistance membrane protein; Provisional; Region: PRK10209
1049565013147	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
1049565013148	acid-resistance protein; Provisional; Region: hdeB; PRK11566
1049565013149	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
1049565013150	amphipathic channel; other site
1049565013151	Asn-Pro-Ala signature motifs; other site
1049565013152	Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841
1049565013153	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1049565013154	Dehydratase small subunit; Region: Dehydratase_SU; pfam02287
1049565013155	propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042
1049565013156	Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909
1049565013157	Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687
1049565013158	alpha-alpha subunit/dimer interface [polypeptide binding]; other site
1049565013159	alpha-beta subunit interface [polypeptide binding]; other site
1049565013160	alpha-gamma subunit interface [polypeptide binding]; other site
1049565013161	active site
1049565013162	substrate and K+ binding site; other site
1049565013163	K+ binding site [ion binding]; other site
1049565013164	cobalamin binding site [chemical binding]; other site
1049565013165	Domain of unknown function (DUF336); Region: DUF336; pfam03928
1049565013166	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1049565013167	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
1049565013168	dimer interface [polypeptide binding]; other site
1049565013169	active site
1049565013170	metal binding site [ion binding]; metal-binding site
1049565013171	Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288
1049565013172	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
1049565013173	DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388
1049565013174	PAS domain; Region: PAS; smart00091
1049565013175	putative active site [active]
1049565013176	heme pocket [chemical binding]; other site
1049565013177	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1049565013178	Walker A motif; other site
1049565013179	ATP binding site [chemical binding]; other site
1049565013180	Walker B motif; other site
1049565013181	arginine finger; other site
1049565013182	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1049565013183	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
1049565013184	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
1049565013185	dimer interface [polypeptide binding]; other site
1049565013186	active site
1049565013187	metal binding site [ion binding]; metal-binding site
1049565013188	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468
1049565013189	Dak1 domain; Region: Dak1; pfam02733
1049565013190	dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005
1049565013191	dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377
1049565013192	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412
1049565013193	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1049565013194	dimerization domain swap beta strand [polypeptide binding]; other site
1049565013195	regulatory protein interface [polypeptide binding]; other site
1049565013196	active site
1049565013197	regulatory phosphorylation site [posttranslational modification]; other site
1049565013198	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1049565013199	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700
1049565013200	dihydroxyacetone kinase, ATP-dependent; Region: dak_ATP; TIGR02361
1049565013201	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
1049565013202	DAK2 domain; Region: Dak2; pfam02734
1049565013203	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
1049565013204	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
1049565013205	FAD binding pocket [chemical binding]; other site
1049565013206	FAD binding motif [chemical binding]; other site
1049565013207	phosphate binding motif [ion binding]; other site
1049565013208	NAD binding pocket [chemical binding]; other site
1049565013209	Predicted transcriptional regulators [Transcription]; Region: COG1695
1049565013210	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1049565013211	GLE1-like protein; Region: GLE1; pfam07817
1049565013212	putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522
1049565013213	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1049565013214	inhibitor-cofactor binding pocket; inhibition site
1049565013215	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565013216	catalytic residue [active]
1049565013217	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
1049565013218	dimer interface [polypeptide binding]; other site
1049565013219	putative tRNA-binding site [nucleotide binding]; other site
1049565013220	DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339
1049565013221	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1049565013222	DNA binding site [nucleotide binding]
1049565013223	domain linker motif; other site
1049565013224	Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544
1049565013225	putative dimerization interface [polypeptide binding]; other site
1049565013226	putative ligand binding site [chemical binding]; other site
1049565013227	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
1049565013228	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1049565013229	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1049565013230	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1049565013231	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
1049565013232	Domain of unknown function (DUF386); Region: DUF386; cl01047
1049565013233	inner membrane transporter YjeM; Provisional; Region: PRK15238
1049565013234	inner membrane transporter YjeM; Provisional; Region: PRK15238
1049565013235	alpha-glucosidase; Provisional; Region: PRK10137
1049565013236	Protein of unknown function, DUF608; Region: DUF608; pfam04685
1049565013237	Trehalase; Region: Trehalase; cl17346
1049565013238	autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486
1049565013239	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
1049565013240	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
1049565013241	putative active site; other site
1049565013242	catalytic residue [active]
1049565013243	autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408
1049565013244	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
1049565013245	ligand binding site [chemical binding]; other site
1049565013246	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1049565013247	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1049565013248	TM-ABC transporter signature motif; other site
1049565013249	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1049565013250	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1049565013251	TM-ABC transporter signature motif; other site
1049565013252	autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439
1049565013253	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1049565013254	Walker A/P-loop; other site
1049565013255	ATP binding site [chemical binding]; other site
1049565013256	Q-loop/lid; other site
1049565013257	ABC transporter signature motif; other site
1049565013258	Walker B; other site
1049565013259	D-loop; other site
1049565013260	H-loop/switch region; other site
1049565013261	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1049565013262	transcriptional regulator LsrR; Provisional; Region: PRK15418
1049565013263	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1049565013264	autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939
1049565013265	Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775
1049565013266	putative N- and C-terminal domain interface [polypeptide binding]; other site
1049565013267	putative active site [active]
1049565013268	putative MgATP binding site [chemical binding]; other site
1049565013269	catalytic site [active]
1049565013270	metal binding site [ion binding]; metal-binding site
1049565013271	putative carbohydrate binding site [chemical binding]; other site
1049565013272	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1049565013273	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
1049565013274	active site
1049565013275	FMN binding site [chemical binding]; other site
1049565013276	2,4-decadienoyl-CoA binding site; other site
1049565013277	catalytic residue [active]
1049565013278	4Fe-4S cluster binding site [ion binding]; other site
1049565013279	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
1049565013280	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1049565013281	SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001
1049565013282	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1049565013283	S-adenosylmethionine binding site [chemical binding]; other site
1049565013284	Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382
1049565013285	B3/4 domain; Region: B3_4; pfam03483
1049565013286	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1049565013287	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1049565013288	non-specific DNA binding site [nucleotide binding]; other site
1049565013289	salt bridge; other site
1049565013290	sequence-specific DNA binding site [nucleotide binding]; other site
1049565013291	Cupin domain; Region: Cupin_2; pfam07883
1049565013292	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
1049565013293	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1049565013294	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1049565013295	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
1049565013296	serine/threonine transporter SstT; Provisional; Region: PRK13628
1049565013297	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1049565013298	Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688
1049565013299	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
1049565013300	galactarate dehydratase; Region: galactar-dH20; TIGR03248
1049565013301	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
1049565013302	Glucuronate isomerase; Region: UxaC; pfam02614
1049565013303	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
1049565013304	D-galactonate transporter; Region: 2A0114; TIGR00893
1049565013305	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565013306	putative substrate translocation pore; other site
1049565013307	DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523
1049565013308	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1049565013309	DNA-binding site [nucleotide binding]; DNA binding site
1049565013310	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1049565013311	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1049565013312	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1049565013313	EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629
1049565013314	Protein of unknown function (DUF1090); Region: DUF1090; pfam06476
1049565013315	Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575
1049565013316	Predicted membrane protein [Function unknown]; Region: COG5393
1049565013317	YqjK-like protein; Region: YqjK; pfam13997
1049565013318	Predicted membrane protein [Function unknown]; Region: COG2259
1049565013319	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
1049565013320	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
1049565013321	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
1049565013322	putative dimer interface [polypeptide binding]; other site
1049565013323	N-terminal domain interface [polypeptide binding]; other site
1049565013324	putative substrate binding pocket (H-site) [chemical binding]; other site
1049565013325	Predicted membrane protein [Function unknown]; Region: COG3152
1049565013326	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565013327	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
1049565013328	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1049565013329	dimerization interface [polypeptide binding]; other site
1049565013330	Pirin-related protein [General function prediction only]; Region: COG1741
1049565013331	Pirin; Region: Pirin; pfam02678
1049565013332	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
1049565013333	dimer interface [polypeptide binding]; other site
1049565013334	tRNA_anti-like; Region: tRNA_anti-like; pfam12869
1049565013335	glycerate kinase I; Provisional; Region: PRK10342
1049565013336	tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559
1049565013337	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1049565013338	alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558
1049565013339	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565013340	D-galactonate transporter; Region: 2A0114; TIGR00893
1049565013341	putative substrate translocation pore; other site
1049565013342	galactarate dehydratase; Region: galactar-dH20; TIGR03248
1049565013343	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
1049565013344	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
1049565013345	SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994
1049565013346	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1049565013347	putative SAM binding site [chemical binding]; other site
1049565013348	putative homodimer interface [polypeptide binding]; other site
1049565013349	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1049565013350	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
1049565013351	putative ligand binding site [chemical binding]; other site
1049565013352	hypothetical protein; Reviewed; Region: PRK12497
1049565013353	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
1049565013354	dimer interface [polypeptide binding]; other site
1049565013355	active site
1049565013356	outer membrane lipoprotein; Provisional; Region: PRK11023
1049565013357	BON domain; Region: BON; pfam04972
1049565013358	BON domain; Region: BON; pfam04972
1049565013359	Predicted permease; Region: DUF318; pfam03773
1049565013360	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
1049565013361	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1049565013362	NAD binding site [chemical binding]; other site
1049565013363	active site
1049565013364	intracellular protease, PfpI family; Region: PfpI; TIGR01382
1049565013365	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
1049565013366	proposed catalytic triad [active]
1049565013367	conserved cys residue [active]
1049565013368	hypothetical protein; Provisional; Region: PRK03467
1049565013369	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
1049565013370	GIY-YIG motif/motif A; other site
1049565013371	putative active site [active]
1049565013372	putative metal binding site [ion binding]; other site
1049565013373	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1049565013374	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1049565013375	Coenzyme A binding pocket [chemical binding]; other site
1049565013376	Putative lipid carrier protein [Lipid metabolism]; Region: COG3154
1049565013377	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1049565013378	Peptidase family U32; Region: Peptidase_U32; pfam01136
1049565013379	putative protease; Provisional; Region: PRK15447
1049565013380	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1049565013381	hypothetical protein; Provisional; Region: PRK10508
1049565013382	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1049565013383	tryptophan permease; Provisional; Region: PRK10483
1049565013384	aromatic amino acid transport protein; Region: araaP; TIGR00837
1049565013385	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
1049565013386	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1049565013387	ATP binding site [chemical binding]; other site
1049565013388	Mg++ binding site [ion binding]; other site
1049565013389	motif III; other site
1049565013390	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1049565013391	nucleotide binding region [chemical binding]; other site
1049565013392	ATP-binding site [chemical binding]; other site
1049565013393	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
1049565013394	putative RNA binding site [nucleotide binding]; other site
1049565013395	lipoprotein NlpI; Provisional; Region: PRK11189
1049565013396	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1049565013397	binding surface
1049565013398	TPR motif; other site
1049565013399	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
1049565013400	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
1049565013401	RNase E interface [polypeptide binding]; other site
1049565013402	trimer interface [polypeptide binding]; other site
1049565013403	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
1049565013404	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
1049565013405	RNase E interface [polypeptide binding]; other site
1049565013406	trimer interface [polypeptide binding]; other site
1049565013407	active site
1049565013408	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1049565013409	putative nucleic acid binding region [nucleotide binding]; other site
1049565013410	G-X-X-G motif; other site
1049565013411	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
1049565013412	RNA binding site [nucleotide binding]; other site
1049565013413	domain interface; other site
1049565013414	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1049565013415	16S/18S rRNA binding site [nucleotide binding]; other site
1049565013416	S13e-L30e interaction site [polypeptide binding]; other site
1049565013417	25S rRNA binding site [nucleotide binding]; other site
1049565013418	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
1049565013419	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1049565013420	RNA binding site [nucleotide binding]; other site
1049565013421	active site
1049565013422	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
1049565013423	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
1049565013424	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1049565013425	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
1049565013426	translation initiation factor IF-2; Region: IF-2; TIGR00487
1049565013427	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1049565013428	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1049565013429	G1 box; other site
1049565013430	putative GEF interaction site [polypeptide binding]; other site
1049565013431	GTP/Mg2+ binding site [chemical binding]; other site
1049565013432	Switch I region; other site
1049565013433	G2 box; other site
1049565013434	G3 box; other site
1049565013435	Switch II region; other site
1049565013436	G4 box; other site
1049565013437	G5 box; other site
1049565013438	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1049565013439	Translation-initiation factor 2; Region: IF-2; pfam11987
1049565013440	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1049565013441	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
1049565013442	NusA N-terminal domain; Region: NusA_N; pfam08529
1049565013443	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1049565013444	RNA binding site [nucleotide binding]; other site
1049565013445	homodimer interface [polypeptide binding]; other site
1049565013446	NusA-like KH domain; Region: KH_5; pfam13184
1049565013447	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1049565013448	G-X-X-G motif; other site
1049565013449	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
1049565013450	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
1049565013451	ribosome maturation protein RimP; Reviewed; Region: PRK00092
1049565013452	Sm and related proteins; Region: Sm_like; cl00259
1049565013453	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
1049565013454	putative oligomer interface [polypeptide binding]; other site
1049565013455	putative RNA binding site [nucleotide binding]; other site
1049565013456	argininosuccinate synthase; Validated; Region: PRK05370
1049565013457	argininosuccinate synthase; Provisional; Region: PRK13820
1049565013458	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832
1049565013459	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
1049565013460	ligand binding site [chemical binding]; other site
1049565013461	flexible hinge region; other site
1049565013462	YfaZ precursor; Region: YfaZ; pfam07437
1049565013463	outer membrane protein; Region: OMP_w_GlyGly; TIGR04219
1049565013464	Preprotein translocase SecG subunit; Region: SecG; pfam03840
1049565013465	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
1049565013466	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1049565013467	active site
1049565013468	substrate binding site [chemical binding]; other site
1049565013469	metal binding site [ion binding]; metal-binding site
1049565013470	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1049565013471	dihydropteroate synthase; Region: DHPS; TIGR01496
1049565013472	substrate binding pocket [chemical binding]; other site
1049565013473	dimer interface [polypeptide binding]; other site
1049565013474	inhibitor binding site; inhibition site
1049565013475	ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733
1049565013476	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1049565013477	Walker A motif; other site
1049565013478	ATP binding site [chemical binding]; other site
1049565013479	Walker B motif; other site
1049565013480	arginine finger; other site
1049565013481	Peptidase family M41; Region: Peptidase_M41; pfam01434
1049565013482	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
1049565013483	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1049565013484	S-adenosylmethionine binding site [chemical binding]; other site
1049565013485	RNA-binding protein YhbY; Provisional; Region: PRK10343
1049565013486	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1049565013487	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1049565013488	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1049565013489	D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113
1049565013490	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
1049565013491	GTPase CgtA; Reviewed; Region: obgE; PRK12298
1049565013492	GTP1/OBG; Region: GTP1_OBG; pfam01018
1049565013493	Obg GTPase; Region: Obg; cd01898
1049565013494	G1 box; other site
1049565013495	GTP/Mg2+ binding site [chemical binding]; other site
1049565013496	Switch I region; other site
1049565013497	G2 box; other site
1049565013498	G3 box; other site
1049565013499	Switch II region; other site
1049565013500	G4 box; other site
1049565013501	G5 box; other site
1049565013502	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1049565013503	EamA-like transporter family; Region: EamA; pfam00892
1049565013504	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
1049565013505	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
1049565013506	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
1049565013507	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1049565013508	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1049565013509	substrate binding pocket [chemical binding]; other site
1049565013510	chain length determination region; other site
1049565013511	substrate-Mg2+ binding site; other site
1049565013512	catalytic residues [active]
1049565013513	aspartate-rich region 1; other site
1049565013514	active site lid residues [active]
1049565013515	aspartate-rich region 2; other site
1049565013516	DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344
1049565013517	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1049565013518	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1049565013519	hinge; other site
1049565013520	active site
1049565013521	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
1049565013522	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1049565013523	anti sigma factor interaction site; other site
1049565013524	regulatory phosphorylation site [posttranslational modification]; other site
1049565013525	ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117
1049565013526	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
1049565013527	mce related protein; Region: MCE; pfam02470
1049565013528	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1049565013529	conserved hypothetical integral membrane protein; Region: TIGR00056
1049565013530	putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831
1049565013531	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
1049565013532	Walker A/P-loop; other site
1049565013533	ATP binding site [chemical binding]; other site
1049565013534	Q-loop/lid; other site
1049565013535	ABC transporter signature motif; other site
1049565013536	Walker B; other site
1049565013537	D-loop; other site
1049565013538	H-loop/switch region; other site
1049565013539	putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734
1049565013540	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1049565013541	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1049565013542	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
1049565013543	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
1049565013544	putative active site [active]
1049565013545	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
1049565013546	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484
1049565013547	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
1049565013548	lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893
1049565013549	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
1049565013550	lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894
1049565013551	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
1049565013552	lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895
1049565013553	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
1049565013554	Walker A/P-loop; other site
1049565013555	ATP binding site [chemical binding]; other site
1049565013556	Q-loop/lid; other site
1049565013557	ABC transporter signature motif; other site
1049565013558	Walker B; other site
1049565013559	D-loop; other site
1049565013560	H-loop/switch region; other site
1049565013561	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
1049565013562	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
1049565013563	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
1049565013564	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
1049565013565	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1049565013566	30S subunit binding site; other site
1049565013567	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1049565013568	active site
1049565013569	phosphorylation site [posttranslational modification]
1049565013570	P-loop ATPase protein family; Region: ATP_bind_2; cl15794
1049565013571	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1049565013572	dimerization domain swap beta strand [polypeptide binding]; other site
1049565013573	regulatory protein interface [polypeptide binding]; other site
1049565013574	active site
1049565013575	regulatory phosphorylation site [posttranslational modification]; other site
1049565013576	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
1049565013577	Transglycosylase; Region: Transgly; cl17702
1049565013578	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
1049565013579	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
1049565013580	conserved cys residue [active]
1049565013581	aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091
1049565013582	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1049565013583	putative active site [active]
1049565013584	heme pocket [chemical binding]; other site
1049565013585	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1049565013586	dimer interface [polypeptide binding]; other site
1049565013587	phosphorylation site [posttranslational modification]
1049565013588	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1049565013589	ATP binding site [chemical binding]; other site
1049565013590	Mg2+ binding site [ion binding]; other site
1049565013591	G-X-G motif; other site
1049565013592	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1049565013593	active site
1049565013594	phosphorylation site [posttranslational modification]
1049565013595	intermolecular recognition site; other site
1049565013596	dimerization interface [polypeptide binding]; other site
1049565013597	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1049565013598	putative binding surface; other site
1049565013599	active site
1049565013600	mannonate dehydratase; Provisional; Region: PRK03906
1049565013601	mannonate dehydratase; Region: uxuA; TIGR00695
1049565013602	putative oxidoreductase; Provisional; Region: PRK10083
1049565013603	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
1049565013604	putative NAD(P) binding site [chemical binding]; other site
1049565013605	catalytic Zn binding site [ion binding]; other site
1049565013606	structural Zn binding site [ion binding]; other site
1049565013607	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565013608	D-galactonate transporter; Region: 2A0114; TIGR00893
1049565013609	putative substrate translocation pore; other site
1049565013610	radical SAM protein, TIGR01212 family; Region: TIGR01212
1049565013611	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1049565013612	FeS/SAM binding site; other site
1049565013613	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
1049565013614	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
1049565013615	active site
1049565013616	dimer interface [polypeptide binding]; other site
1049565013617	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
1049565013618	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1049565013619	active site
1049565013620	FMN binding site [chemical binding]; other site
1049565013621	substrate binding site [chemical binding]; other site
1049565013622	3Fe-4S cluster binding site [ion binding]; other site
1049565013623	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
1049565013624	domain interface; other site
1049565013625	glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318
1049565013626	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1049565013627	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1049565013628	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1049565013629	Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010
1049565013630	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
1049565013631	putative active site cavity [active]
1049565013632	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
1049565013633	stringent starvation protein A; Provisional; Region: sspA; PRK09481
1049565013634	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
1049565013635	C-terminal domain interface [polypeptide binding]; other site
1049565013636	putative GSH binding site (G-site) [chemical binding]; other site
1049565013637	dimer interface [polypeptide binding]; other site
1049565013638	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
1049565013639	dimer interface [polypeptide binding]; other site
1049565013640	N-terminal domain interface [polypeptide binding]; other site
1049565013641	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1049565013642	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1049565013643	23S rRNA interface [nucleotide binding]; other site
1049565013644	L3 interface [polypeptide binding]; other site
1049565013645	Predicted ATPase [General function prediction only]; Region: COG1485
1049565013646	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105
1049565013647	hypothetical protein; Provisional; Region: PRK11677
1049565013648	serine endoprotease; Provisional; Region: PRK10139
1049565013649	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1049565013650	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1049565013651	protein binding site [polypeptide binding]; other site
1049565013652	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1049565013653	serine endoprotease; Provisional; Region: PRK10898
1049565013654	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1049565013655	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1049565013656	protein binding site [polypeptide binding]; other site
1049565013657	malate dehydrogenase; Provisional; Region: PRK05086
1049565013658	Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337
1049565013659	NAD binding site [chemical binding]; other site
1049565013660	dimerization interface [polypeptide binding]; other site
1049565013661	Substrate binding site [chemical binding]; other site
1049565013662	arginine repressor; Provisional; Region: PRK05066
1049565013663	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1049565013664	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1049565013665	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
1049565013666	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
1049565013667	Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142
1049565013668	RNAase interaction site [polypeptide binding]; other site
1049565013669	p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631
1049565013670	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1049565013671	Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027
1049565013672	p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559
1049565013673	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1049565013674	HlyD family secretion protein; Region: HlyD_3; pfam13437
1049565013675	efflux system membrane protein; Provisional; Region: PRK11594
1049565013676	transcriptional regulator; Provisional; Region: PRK10632
1049565013677	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565013678	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1049565013679	putative effector binding pocket; other site
1049565013680	dimerization interface [polypeptide binding]; other site
1049565013681	protease TldD; Provisional; Region: tldD; PRK10735
1049565013682	hypothetical protein; Provisional; Region: PRK10899
1049565013683	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1049565013684	ribonuclease G; Provisional; Region: PRK11712
1049565013685	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
1049565013686	homodimer interface [polypeptide binding]; other site
1049565013687	oligonucleotide binding site [chemical binding]; other site
1049565013688	Maf-like protein; Region: Maf; pfam02545
1049565013689	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1049565013690	active site
1049565013691	dimer interface [polypeptide binding]; other site
1049565013692	rod shape-determining protein MreD; Provisional; Region: PRK11060
1049565013693	rod shape-determining protein MreC; Region: mreC; TIGR00219
1049565013694	rod shape-determining protein MreC; Region: MreC; pfam04085
1049565013695	rod shape-determining protein MreB; Provisional; Region: PRK13927
1049565013696	MreB and similar proteins; Region: MreB_like; cd10225
1049565013697	nucleotide binding site [chemical binding]; other site
1049565013698	Mg binding site [ion binding]; other site
1049565013699	putative protofilament interaction site [polypeptide binding]; other site
1049565013700	RodZ interaction site [polypeptide binding]; other site
1049565013701	regulatory protein CsrD; Provisional; Region: PRK11059
1049565013702	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1049565013703	metal binding site [ion binding]; metal-binding site
1049565013704	active site
1049565013705	I-site; other site
1049565013706	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1049565013707	TMAO/DMSO reductase; Reviewed; Region: PRK05363
1049565013708	YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107
1049565013709	Moco binding site; other site
1049565013710	metal coordination site [ion binding]; other site
1049565013711	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
1049565013712	Dehydroquinase class II; Region: DHquinase_II; pfam01220
1049565013713	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
1049565013714	trimer interface [polypeptide binding]; other site
1049565013715	active site
1049565013716	dimer interface [polypeptide binding]; other site
1049565013717	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
1049565013718	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1049565013719	carboxyltransferase (CT) interaction site; other site
1049565013720	biotinylation site [posttranslational modification]; other site
1049565013721	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1049565013722	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1049565013723	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1049565013724	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1049565013725	hypothetical protein; Provisional; Region: PRK10633
1049565013726	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1049565013727	Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327
1049565013728	Na binding site [ion binding]; other site
1049565013729	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
1049565013730	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1049565013731	tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415
1049565013732	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1049565013733	FMN binding site [chemical binding]; other site
1049565013734	active site
1049565013735	catalytic residues [active]
1049565013736	substrate binding site [chemical binding]; other site
1049565013737	Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901
1049565013738	global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430
1049565013739	DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975
1049565013740	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1049565013741	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
1049565013742	multidrug efflux system protein MdtE; Provisional; Region: PRK09859
1049565013743	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1049565013744	HlyD family secretion protein; Region: HlyD_3; pfam13437
1049565013745	multidrug efflux system protein AcrB; Provisional; Region: PRK15127
1049565013746	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1049565013747	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
1049565013748	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
1049565013749	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
1049565013750	trimer interface [polypeptide binding]; other site
1049565013751	putative metal binding site [ion binding]; other site
1049565013752	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
1049565013753	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
1049565013754	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1049565013755	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1049565013756	shikimate binding site; other site
1049565013757	NAD(P) binding site [chemical binding]; other site
1049565013758	tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634
1049565013759	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1049565013760	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
1049565013761	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1049565013762	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1049565013763	hypothetical protein; Validated; Region: PRK03430
1049565013764	hypothetical protein; Provisional; Region: PRK10736
1049565013765	DNA protecting protein DprA; Region: dprA; TIGR00732
1049565013766	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1049565013767	active site
1049565013768	catalytic residues [active]
1049565013769	metal binding site [ion binding]; metal-binding site
1049565013770	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1049565013771	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1049565013772	putative active site [active]
1049565013773	substrate binding site [chemical binding]; other site
1049565013774	putative cosubstrate binding site; other site
1049565013775	catalytic site [active]
1049565013776	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1049565013777	substrate binding site [chemical binding]; other site
1049565013778	16S rRNA methyltransferase B; Provisional; Region: PRK10901
1049565013779	N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620
1049565013780	putative RNA binding site [nucleotide binding]; other site
1049565013781	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1049565013782	S-adenosylmethionine binding site [chemical binding]; other site
1049565013783	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
1049565013784	TrkA-N domain; Region: TrkA_N; pfam02254
1049565013785	TrkA-C domain; Region: TrkA_C; pfam02080
1049565013786	TrkA-N domain; Region: TrkA_N; pfam02254
1049565013787	TrkA-C domain; Region: TrkA_C; pfam02080
1049565013788	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
1049565013789	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
1049565013790	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036
1049565013791	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1049565013792	Integrase core domain; Region: rve; pfam00665
1049565013793	Integrase core domain; Region: rve_3; pfam13683
1049565013794	zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514
1049565013795	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
1049565013796	DNA binding residues [nucleotide binding]
1049565013797	dimer interface [polypeptide binding]; other site
1049565013798	metal binding site [ion binding]; metal-binding site
1049565013799	hypothetical protein; Provisional; Region: PRK10203
1049565013800	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1049565013801	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1049565013802	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1049565013803	alphaNTD homodimer interface [polypeptide binding]; other site
1049565013804	alphaNTD - beta interaction site [polypeptide binding]; other site
1049565013805	alphaNTD - beta' interaction site [polypeptide binding]; other site
1049565013806	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1049565013807	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1049565013808	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1049565013809	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1049565013810	RNA binding surface [nucleotide binding]; other site
1049565013811	30S ribosomal protein S11; Validated; Region: PRK05309
1049565013812	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
1049565013813	30S ribosomal protein S13; Region: bact_S13; TIGR03631
1049565013814	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1049565013815	SecY translocase; Region: SecY; pfam00344
1049565013816	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1049565013817	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
1049565013818	23S rRNA binding site [nucleotide binding]; other site
1049565013819	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
1049565013820	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1049565013821	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1049565013822	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1049565013823	23S rRNA interface [nucleotide binding]; other site
1049565013824	5S rRNA interface [nucleotide binding]; other site
1049565013825	L27 interface [polypeptide binding]; other site
1049565013826	L5 interface [polypeptide binding]; other site
1049565013827	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1049565013828	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1049565013829	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1049565013830	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1049565013831	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
1049565013832	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1049565013833	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1049565013834	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1049565013835	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1049565013836	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1049565013837	RNA binding site [nucleotide binding]; other site
1049565013838	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
1049565013839	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1049565013840	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
1049565013841	23S rRNA interface [nucleotide binding]; other site
1049565013842	putative translocon interaction site; other site
1049565013843	signal recognition particle (SRP54) interaction site; other site
1049565013844	L23 interface [polypeptide binding]; other site
1049565013845	trigger factor interaction site; other site
1049565013846	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1049565013847	23S rRNA interface [nucleotide binding]; other site
1049565013848	5S rRNA interface [nucleotide binding]; other site
1049565013849	putative antibiotic binding site [chemical binding]; other site
1049565013850	L25 interface [polypeptide binding]; other site
1049565013851	L27 interface [polypeptide binding]; other site
1049565013852	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1049565013853	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1049565013854	G-X-X-G motif; other site
1049565013855	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1049565013856	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1049565013857	protein-rRNA interface [nucleotide binding]; other site
1049565013858	putative translocon binding site; other site
1049565013859	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
1049565013860	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1049565013861	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1049565013862	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1049565013863	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1049565013864	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1049565013865	50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625
1049565013866	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1049565013867	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
1049565013868	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
1049565013869	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
1049565013870	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
1049565013871	heme binding site [chemical binding]; other site
1049565013872	ferroxidase pore; other site
1049565013873	ferroxidase diiron center [ion binding]; other site
1049565013874	bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509
1049565013875	elongation factor Tu; Reviewed; Region: PRK00049
1049565013876	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1049565013877	G1 box; other site
1049565013878	GEF interaction site [polypeptide binding]; other site
1049565013879	GTP/Mg2+ binding site [chemical binding]; other site
1049565013880	Switch I region; other site
1049565013881	G2 box; other site
1049565013882	G3 box; other site
1049565013883	Switch II region; other site
1049565013884	G4 box; other site
1049565013885	G5 box; other site
1049565013886	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1049565013887	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1049565013888	Antibiotic Binding Site [chemical binding]; other site
1049565013889	elongation factor G; Reviewed; Region: PRK00007
1049565013890	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1049565013891	G1 box; other site
1049565013892	putative GEF interaction site [polypeptide binding]; other site
1049565013893	GTP/Mg2+ binding site [chemical binding]; other site
1049565013894	Switch I region; other site
1049565013895	G2 box; other site
1049565013896	G3 box; other site
1049565013897	Switch II region; other site
1049565013898	G4 box; other site
1049565013899	G5 box; other site
1049565013900	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1049565013901	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1049565013902	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1049565013903	30S ribosomal protein S7; Validated; Region: PRK05302
1049565013904	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1049565013905	S17 interaction site [polypeptide binding]; other site
1049565013906	S8 interaction site; other site
1049565013907	16S rRNA interaction site [nucleotide binding]; other site
1049565013908	streptomycin interaction site [chemical binding]; other site
1049565013909	23S rRNA interaction site [nucleotide binding]; other site
1049565013910	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1049565013911	sulfur transfer complex subunit TusB; Provisional; Region: PRK13510
1049565013912	sulfur relay protein TusC; Validated; Region: PRK00211
1049565013913	sulfur transfer complex subunit TusD; Validated; Region: PRK00207
1049565013914	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
1049565013915	YheO-like PAS domain; Region: PAS_6; pfam08348
1049565013916	HTH domain; Region: HTH_22; pfam13309
1049565013917	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902
1049565013918	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
1049565013919	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1049565013920	phi X174 lysis protein; Provisional; Region: PRK02793
1049565013921	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10737
1049565013922	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1049565013923	Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529
1049565013924	glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659
1049565013925	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
1049565013926	TrkA-N domain; Region: TrkA_N; pfam02254
1049565013927	glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930
1049565013928	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
1049565013929	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1049565013930	Walker A/P-loop; other site
1049565013931	ATP binding site [chemical binding]; other site
1049565013932	Q-loop/lid; other site
1049565013933	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1049565013934	ABC transporter signature motif; other site
1049565013935	Walker B; other site
1049565013936	D-loop; other site
1049565013937	ABC transporter; Region: ABC_tran_2; pfam12848
1049565013938	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1049565013939	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
1049565013940	putative hydrolase; Provisional; Region: PRK10985
1049565013941	hypothetical protein; Provisional; Region: PRK04966
1049565013942	Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029
1049565013943	active site
1049565013944	hypothetical protein; Provisional; Region: PRK10738
1049565013945	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
1049565013946	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1049565013947	ligand binding site [chemical binding]; other site
1049565013948	flexible hinge region; other site
1049565013949	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1049565013950	putative switch regulator; other site
1049565013951	non-specific DNA interactions [nucleotide binding]; other site
1049565013952	DNA binding site [nucleotide binding]
1049565013953	sequence specific DNA binding site [nucleotide binding]; other site
1049565013954	putative cAMP binding site [chemical binding]; other site
1049565013955	integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667
1049565013956	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
1049565013957	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1049565013958	bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093
1049565013959	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1049565013960	inhibitor-cofactor binding pocket; inhibition site
1049565013961	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565013962	catalytic residue [active]
1049565013963	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
1049565013964	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1049565013965	glutamine binding [chemical binding]; other site
1049565013966	catalytic triad [active]
1049565013967	Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184
1049565013968	cell filamentation protein Fic; Provisional; Region: PRK10347
1049565013969	hypothetical protein; Provisional; Region: PRK10204
1049565013970	peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903
1049565013971	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
1049565013972	substrate binding site [chemical binding]; other site
1049565013973	putative transporter; Provisional; Region: PRK03699
1049565013974	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565013975	putative substrate translocation pore; other site
1049565013976	cytosine deaminase; Provisional; Region: PRK09230
1049565013977	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
1049565013978	active site
1049565013979	nitrite reductase subunit NirD; Provisional; Region: PRK14989
1049565013980	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1049565013981	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1049565013982	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1049565013983	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
1049565013984	siroheme synthase; Provisional; Region: cysG; PRK10637
1049565013985	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
1049565013986	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
1049565013987	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1049565013988	active site
1049565013989	SAM binding site [chemical binding]; other site
1049565013990	homodimer interface [polypeptide binding]; other site
1049565013991	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1049565013992	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1049565013993	active site
1049565013994	HIGH motif; other site
1049565013995	dimer interface [polypeptide binding]; other site
1049565013996	KMSKS motif; other site
1049565013997	phosphoglycolate phosphatase; Provisional; Region: PRK13222
1049565013998	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1049565013999	motif II; other site
1049565014000	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1049565014001	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
1049565014002	substrate binding site [chemical binding]; other site
1049565014003	hexamer interface [polypeptide binding]; other site
1049565014004	metal binding site [ion binding]; metal-binding site
1049565014005	DNA adenine methylase; Provisional; Region: PRK10904
1049565014006	cell division protein DamX; Validated; Region: PRK10905
1049565014007	hypothetical protein; Reviewed; Region: PRK11901
1049565014008	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
1049565014009	active site
1049565014010	dimer interface [polypeptide binding]; other site
1049565014011	metal binding site [ion binding]; metal-binding site
1049565014012	shikimate kinase; Reviewed; Region: aroK; PRK00131
1049565014013	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1049565014014	ADP binding site [chemical binding]; other site
1049565014015	magnesium binding site [ion binding]; other site
1049565014016	putative shikimate binding site; other site
1049565014017	outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560
1049565014018	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1049565014019	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1049565014020	Protein of unknown function (DUF2531); Region: DUF2531; pfam10748
1049565014021	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
1049565014022	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
1049565014023	penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636
1049565014024	Transglycosylase; Region: Transgly; pfam00912
1049565014025	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1049565014026	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
1049565014027	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1049565014028	ADP-ribose binding site [chemical binding]; other site
1049565014029	dimer interface [polypeptide binding]; other site
1049565014030	active site
1049565014031	nudix motif; other site
1049565014032	metal binding site [ion binding]; metal-binding site
1049565014033	Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095
1049565014034	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
1049565014035	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1049565014036	motif II; other site
1049565014037	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1049565014038	RNA binding surface [nucleotide binding]; other site
1049565014039	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
1049565014040	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
1049565014041	dimerization interface [polypeptide binding]; other site
1049565014042	domain crossover interface; other site
1049565014043	redox-dependent activation switch; other site
1049565014044	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
1049565014045	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
1049565014046	active site
1049565014047	substrate-binding site [chemical binding]; other site
1049565014048	metal-binding site [ion binding]
1049565014049	ATP binding site [chemical binding]; other site
1049565014050	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
1049565014051	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1049565014052	dimerization interface [polypeptide binding]; other site
1049565014053	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1049565014054	dimer interface [polypeptide binding]; other site
1049565014055	phosphorylation site [posttranslational modification]
1049565014056	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1049565014057	ATP binding site [chemical binding]; other site
1049565014058	Mg2+ binding site [ion binding]; other site
1049565014059	G-X-G motif; other site
1049565014060	osmolarity response regulator; Provisional; Region: ompR; PRK09468
1049565014061	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1049565014062	active site
1049565014063	phosphorylation site [posttranslational modification]
1049565014064	intermolecular recognition site; other site
1049565014065	dimerization interface [polypeptide binding]; other site
1049565014066	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1049565014067	DNA binding site [nucleotide binding]
1049565014068	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
1049565014069	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1049565014070	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1049565014071	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
1049565014072	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
1049565014073	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
1049565014074	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
1049565014075	RNA binding site [nucleotide binding]; other site
1049565014076	ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555
1049565014077	ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554
1049565014078	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
1049565014079	G1 box; other site
1049565014080	GTP/Mg2+ binding site [chemical binding]; other site
1049565014081	Switch I region; other site
1049565014082	G2 box; other site
1049565014083	G3 box; other site
1049565014084	Switch II region; other site
1049565014085	G4 box; other site
1049565014086	G5 box; other site
1049565014087	Nucleoside recognition; Region: Gate; pfam07670
1049565014088	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
1049565014089	Nucleoside recognition; Region: Gate; pfam07670
1049565014090	ferrous iron transport protein FeoC; Provisional; Region: PRK15431
1049565014091	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
1049565014092	carboxylesterase BioH; Provisional; Region: PRK10349
1049565014093	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1049565014094	catalytic site [active]
1049565014095	DNA utilization protein GntX; Provisional; Region: PRK11595
1049565014096	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1049565014097	active site
1049565014098	Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190
1049565014099	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
1049565014100	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
1049565014101	high-affinity gluconate transporter; Provisional; Region: PRK14984
1049565014102	gluconate transporter; Region: gntP; TIGR00791
1049565014103	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
1049565014104	4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711
1049565014105	maltodextrin phosphorylase; Provisional; Region: PRK14985
1049565014106	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
1049565014107	homodimer interface [polypeptide binding]; other site
1049565014108	active site pocket [active]
1049565014109	transcriptional regulator MalT; Provisional; Region: PRK04841
1049565014110	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1049565014111	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1049565014112	DNA binding residues [nucleotide binding]
1049565014113	dimerization interface [polypeptide binding]; other site
1049565014114	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
1049565014115	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1049565014116	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1049565014117	intramembrane serine protease GlpG; Provisional; Region: PRK10907
1049565014118	Protein of unknown function (DUF3582); Region: DUF3582; pfam12122
1049565014119	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
1049565014120	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
1049565014121	active site residue [active]
1049565014122	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
1049565014123	glycogen phosphorylase; Provisional; Region: PRK14986
1049565014124	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
1049565014125	homodimer interface [polypeptide binding]; other site
1049565014126	active site pocket [active]
1049565014127	glycogen synthase; Provisional; Region: glgA; PRK00654
1049565014128	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
1049565014129	ADP-binding pocket [chemical binding]; other site
1049565014130	homodimer interface [polypeptide binding]; other site
1049565014131	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
1049565014132	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
1049565014133	ligand binding site; other site
1049565014134	oligomer interface; other site
1049565014135	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
1049565014136	dimer interface [polypeptide binding]; other site
1049565014137	N-terminal domain interface [polypeptide binding]; other site
1049565014138	sulfate 1 binding site; other site
1049565014139	glycogen debranching enzyme; Provisional; Region: PRK03705
1049565014140	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
1049565014141	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
1049565014142	active site
1049565014143	catalytic site [active]
1049565014144	glycogen branching enzyme; Provisional; Region: PRK05402
1049565014145	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
1049565014146	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
1049565014147	active site
1049565014148	catalytic site [active]
1049565014149	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
1049565014150	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
1049565014151	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1049565014152	low affinity gluconate transporter; Provisional; Region: PRK10472
1049565014153	gluconate transporter; Region: gntP; TIGR00791
1049565014154	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
1049565014155	gluconate operon transcriptional regulator; Provisional; Region: PRK14987
1049565014156	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1049565014157	DNA binding site [nucleotide binding]
1049565014158	domain linker motif; other site
1049565014159	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
1049565014160	putative ligand binding site [chemical binding]; other site
1049565014161	putative dimerization interface [polypeptide binding]; other site
1049565014162	Pirin-related protein [General function prediction only]; Region: COG1741
1049565014163	Pirin; Region: Pirin; pfam02678
1049565014164	putative oxidoreductase; Provisional; Region: PRK10206
1049565014165	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1049565014166	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1049565014167	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
1049565014168	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
1049565014169	putative acetyltransferase YhhY; Provisional; Region: PRK10140
1049565014170	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1049565014171	Coenzyme A binding pocket [chemical binding]; other site
1049565014172	gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615
1049565014173	gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066
1049565014174	Protein of unknown function (DUF2756); Region: DUF2756; pfam10956
1049565014175	cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454
1049565014176	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
1049565014177	putative active site [active]
1049565014178	catalytic site [active]
1049565014179	putative metal binding site [ion binding]; other site
1049565014180	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1049565014181	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1049565014182	Walker A/P-loop; other site
1049565014183	ATP binding site [chemical binding]; other site
1049565014184	Q-loop/lid; other site
1049565014185	ABC transporter signature motif; other site
1049565014186	Walker B; other site
1049565014187	D-loop; other site
1049565014188	H-loop/switch region; other site
1049565014189	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1049565014190	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565014191	dimer interface [polypeptide binding]; other site
1049565014192	conserved gate region; other site
1049565014193	ABC-ATPase subunit interface; other site
1049565014194	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1049565014195	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565014196	dimer interface [polypeptide binding]; other site
1049565014197	conserved gate region; other site
1049565014198	putative PBP binding loops; other site
1049565014199	ABC-ATPase subunit interface; other site
1049565014200	glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974
1049565014201	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1049565014202	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614
1049565014203	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1049565014204	Walker A/P-loop; other site
1049565014205	ATP binding site [chemical binding]; other site
1049565014206	Q-loop/lid; other site
1049565014207	ABC transporter signature motif; other site
1049565014208	Walker B; other site
1049565014209	D-loop; other site
1049565014210	H-loop/switch region; other site
1049565014211	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
1049565014212	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1049565014213	Walker A/P-loop; other site
1049565014214	ATP binding site [chemical binding]; other site
1049565014215	Q-loop/lid; other site
1049565014216	ABC transporter signature motif; other site
1049565014217	Walker B; other site
1049565014218	D-loop; other site
1049565014219	H-loop/switch region; other site
1049565014220	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
1049565014221	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
1049565014222	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1049565014223	TM-ABC transporter signature motif; other site
1049565014224	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1049565014225	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1049565014226	TM-ABC transporter signature motif; other site
1049565014227	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1049565014228	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
1049565014229	dimerization interface [polypeptide binding]; other site
1049565014230	ligand binding site [chemical binding]; other site
1049565014231	Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568
1049565014232	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1049565014233	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
1049565014234	dimerization interface [polypeptide binding]; other site
1049565014235	ligand binding site [chemical binding]; other site
1049565014236	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
1049565014237	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
1049565014238	4-aminobutyrate aminotransferase; Provisional; Region: PRK06777
1049565014239	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1049565014240	inhibitor-cofactor binding pocket; inhibition site
1049565014241	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565014242	catalytic residue [active]
1049565014243	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1049565014244	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1049565014245	DNA-binding site [nucleotide binding]; DNA binding site
1049565014246	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1049565014247	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565014248	homodimer interface [polypeptide binding]; other site
1049565014249	catalytic residue [active]
1049565014250	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
1049565014251	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1049565014252	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1049565014253	DNA binding residues [nucleotide binding]
1049565014254	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
1049565014255	putative protein insertion permease FtsX; Region: ftsX; TIGR00439
1049565014256	cell division protein FtsE; Provisional; Region: PRK10908
1049565014257	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1049565014258	Walker A/P-loop; other site
1049565014259	ATP binding site [chemical binding]; other site
1049565014260	Q-loop/lid; other site
1049565014261	ABC transporter signature motif; other site
1049565014262	Walker B; other site
1049565014263	D-loop; other site
1049565014264	H-loop/switch region; other site
1049565014265	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
1049565014266	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
1049565014267	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1049565014268	P loop; other site
1049565014269	GTP binding site [chemical binding]; other site
1049565014270	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
1049565014271	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1049565014272	S-adenosylmethionine binding site [chemical binding]; other site
1049565014273	hypothetical protein; Provisional; Region: PRK10910
1049565014274	Protein of unknown function (DUF2500); Region: DUF2500; pfam10694
1049565014275	Predicted membrane protein [Function unknown]; Region: COG3714
1049565014276	zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033
1049565014277	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1049565014278	metal-binding site [ion binding]
1049565014279	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1049565014280	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
1049565014281	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
1049565014282	CPxP  motif; other site
1049565014283	hypothetical protein; Provisional; Region: PRK11212
1049565014284	hypothetical protein; Provisional; Region: PRK11615
1049565014285	major facilitator superfamily transporter; Provisional; Region: PRK05122
1049565014286	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565014287	putative substrate translocation pore; other site
1049565014288	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
1049565014289	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1049565014290	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
1049565014291	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051
1049565014292	4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279
1049565014293	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
1049565014294	4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394
1049565014295	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
1049565014296	bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125
1049565014297	ArnA, N-terminal formyltransferase domain; Region: FMT_core_ArnA_N; cd08644
1049565014298	substrate binding site [chemical binding]; other site
1049565014299	cosubstrate binding site; other site
1049565014300	catalytic site [active]
1049565014301	C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702
1049565014302	active site
1049565014303	hexamer interface [polypeptide binding]; other site
1049565014304	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
1049565014305	NAD binding site [chemical binding]; other site
1049565014306	substrate binding site [chemical binding]; other site
1049565014307	active site
1049565014308	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1049565014309	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1049565014310	Ligand binding site; other site
1049565014311	Putative Catalytic site; other site
1049565014312	DXD motif; other site
1049565014313	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1049565014314	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1049565014315	inhibitor-cofactor binding pocket; inhibition site
1049565014316	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565014317	catalytic residue [active]
1049565014318	Phenolic acid decarboxylase (PAD); Region: PA_decarbox; pfam05870
1049565014319	putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791
1049565014320	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565014321	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1049565014322	dimerization interface [polypeptide binding]; other site
1049565014323	The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489
1049565014324	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1049565014325	substrate binding site [chemical binding]; other site
1049565014326	nickel transporter permease NikB; Provisional; Region: PRK10352
1049565014327	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565014328	dimer interface [polypeptide binding]; other site
1049565014329	conserved gate region; other site
1049565014330	putative PBP binding loops; other site
1049565014331	ABC-ATPase subunit interface; other site
1049565014332	nickel transporter permease NikC; Provisional; Region: nikC; PRK10417
1049565014333	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565014334	dimer interface [polypeptide binding]; other site
1049565014335	conserved gate region; other site
1049565014336	putative PBP binding loops; other site
1049565014337	ABC-ATPase subunit interface; other site
1049565014338	nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418
1049565014339	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1049565014340	Walker A/P-loop; other site
1049565014341	ATP binding site [chemical binding]; other site
1049565014342	Q-loop/lid; other site
1049565014343	ABC transporter signature motif; other site
1049565014344	Walker B; other site
1049565014345	D-loop; other site
1049565014346	H-loop/switch region; other site
1049565014347	nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419
1049565014348	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1049565014349	Walker A/P-loop; other site
1049565014350	ATP binding site [chemical binding]; other site
1049565014351	Q-loop/lid; other site
1049565014352	ABC transporter signature motif; other site
1049565014353	Walker B; other site
1049565014354	D-loop; other site
1049565014355	H-loop/switch region; other site
1049565014356	nickel responsive regulator; Provisional; Region: PRK02967
1049565014357	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
1049565014358	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
1049565014359	HicB family; Region: HicB; pfam05534
1049565014360	FOG: CBS domain [General function prediction only]; Region: COG0517
1049565014361	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
1049565014362	Divalent cation transporter; Region: MgtE; pfam01769
1049565014363	Predicted flavoproteins [General function prediction only]; Region: COG2081
1049565014364	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1049565014365	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1049565014366	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1049565014367	universal stress protein UspB; Provisional; Region: PRK04960
1049565014368	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1049565014369	Ligand Binding Site [chemical binding]; other site
1049565014370	dipeptide/tripeptide permease B; Provisional; Region: PRK10207
1049565014371	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565014372	POT family; Region: PTR2; pfam00854
1049565014373	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1049565014374	S-adenosylmethionine binding site [chemical binding]; other site
1049565014375	oligopeptidase A; Provisional; Region: PRK10911
1049565014376	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
1049565014377	active site
1049565014378	Zn binding site [ion binding]; other site
1049565014379	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
1049565014380	active site
1049565014381	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1049565014382	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
1049565014383	glutathione reductase; Validated; Region: PRK06116
1049565014384	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1049565014385	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1049565014386	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1049565014387	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1049565014388	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1049565014389	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
1049565014390	putative N-terminal domain interface [polypeptide binding]; other site
1049565014391	putative dimer interface [polypeptide binding]; other site
1049565014392	putative substrate binding pocket (H-site) [chemical binding]; other site
1049565014393	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1049565014394	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183
1049565014395	putative active site [active]
1049565014396	metal binding site [ion binding]; metal-binding site
1049565014397	trehalase; Provisional; Region: treF; PRK13270
1049565014398	Trehalase; Region: Trehalase; pfam01204
1049565014399	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1049565014400	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1049565014401	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1049565014402	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1049565014403	NAD(P) binding site [chemical binding]; other site
1049565014404	active site
1049565014405	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565014406	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565014407	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
1049565014408	putative effector binding pocket; other site
1049565014409	putative dimerization interface [polypeptide binding]; other site
1049565014410	inner membrane protein YhjD; Region: TIGR00766
1049565014411	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565014412	metabolite-proton symporter; Region: 2A0106; TIGR00883
1049565014413	putative substrate translocation pore; other site
1049565014414	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
1049565014415	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1049565014416	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1049565014417	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1049565014418	substrate binding site [chemical binding]; other site
1049565014419	ATP binding site [chemical binding]; other site
1049565014420	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1049565014421	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1049565014422	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
1049565014423	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1049565014424	putative diguanylate cyclase; Provisional; Region: PRK13561
1049565014425	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1049565014426	dimerization interface [polypeptide binding]; other site
1049565014427	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1049565014428	metal binding site [ion binding]; metal-binding site
1049565014429	active site
1049565014430	I-site; other site
1049565014431	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1049565014432	cellulose synthase subunit BcsC; Provisional; Region: PRK11447
1049565014433	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1049565014434	TPR motif; other site
1049565014435	binding surface
1049565014436	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1049565014437	binding surface
1049565014438	TPR motif; other site
1049565014439	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1049565014440	binding surface
1049565014441	TPR motif; other site
1049565014442	Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420
1049565014443	endo-1,4-D-glucanase; Provisional; Region: PRK11097
1049565014444	cellulose synthase regulator protein; Provisional; Region: PRK11114
1049565014445	cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498
1049565014446	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1049565014447	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
1049565014448	DXD motif; other site
1049565014449	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1049565014450	PilZ domain; Region: PilZ; pfam07238
1049565014451	cell division protein; Provisional; Region: PRK10037
1049565014452	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1049565014453	Protein of unknown function (DUF2629); Region: DUF2629; pfam10945
1049565014454	cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045
1049565014455	Protein of unknown function (DUF2819); Region: DUF2819; pfam10995
1049565014456	Protein of unknown function (DUF2636); Region: DUF2636; pfam11120
1049565014457	Protein of unknown function (DUF3260); Region: DUF3260; pfam11658
1049565014458	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; pfam01270
1049565014459	Cellulose synthase subunit D; Region: Cellsynth_D; pfam03500
1049565014460	cellulose synthase subunit BcsC; Provisional; Region: PRK11447
1049565014461	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1049565014462	TPR motif; other site
1049565014463	binding surface
1049565014464	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1049565014465	Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420
1049565014466	Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420
1049565014467	cellulose synthase regulator protein; Provisional; Region: PRK11114
1049565014468	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
1049565014469	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
1049565014470	DXD motif; other site
1049565014471	PilZ domain; Region: PilZ; pfam07238
1049565014472	cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371
1049565014473	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1049565014474	P-loop; other site
1049565014475	Magnesium ion binding site [ion binding]; other site
1049565014476	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
1049565014477	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1049565014478	Walker A/P-loop; other site
1049565014479	ATP binding site [chemical binding]; other site
1049565014480	Q-loop/lid; other site
1049565014481	ABC transporter signature motif; other site
1049565014482	Walker B; other site
1049565014483	D-loop; other site
1049565014484	H-loop/switch region; other site
1049565014485	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1049565014486	dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022
1049565014487	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1049565014488	Walker A/P-loop; other site
1049565014489	ATP binding site [chemical binding]; other site
1049565014490	Q-loop/lid; other site
1049565014491	ABC transporter signature motif; other site
1049565014492	Walker B; other site
1049565014493	D-loop; other site
1049565014494	H-loop/switch region; other site
1049565014495	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1049565014496	dipeptide transporter; Provisional; Region: PRK10913
1049565014497	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1049565014498	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565014499	dimer interface [polypeptide binding]; other site
1049565014500	conserved gate region; other site
1049565014501	putative PBP binding loops; other site
1049565014502	ABC-ATPase subunit interface; other site
1049565014503	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1049565014504	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565014505	dimer interface [polypeptide binding]; other site
1049565014506	conserved gate region; other site
1049565014507	putative PBP binding loops; other site
1049565014508	ABC-ATPase subunit interface; other site
1049565014509	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1049565014510	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
1049565014511	peptide binding site [polypeptide binding]; other site
1049565014512	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1049565014513	Helix-turn-helix domain; Region: HTH_28; pfam13518
1049565014514	Helix-turn-helix domain; Region: HTH_28; pfam13518
1049565014515	putative transposase OrfB; Reviewed; Region: PHA02517
1049565014516	HTH-like domain; Region: HTH_21; pfam13276
1049565014517	Integrase core domain; Region: rve; pfam00665
1049565014518	Integrase core domain; Region: rve_2; pfam13333
1049565014519	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1049565014520	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1049565014521	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1049565014522	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1049565014523	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1049565014524	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1049565014525	phosphoethanolamine transferase; Provisional; Region: PRK11560
1049565014526	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
1049565014527	Sulfatase; Region: Sulfatase; pfam00884
1049565014528	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
1049565014529	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565014530	putative substrate translocation pore; other site
1049565014531	Autotransporter beta-domain; Region: Autotransporter; cl17461
1049565014532	3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353
1049565014533	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1049565014534	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1049565014535	Coenzyme A binding pocket [chemical binding]; other site
1049565014536	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
1049565014537	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
1049565014538	molybdopterin cofactor binding site [chemical binding]; other site
1049565014539	substrate binding site [chemical binding]; other site
1049565014540	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
1049565014541	molybdopterin cofactor binding site; other site
1049565014542	putative outer membrane lipoprotein; Provisional; Region: PRK10510
1049565014543	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1049565014544	ligand binding site [chemical binding]; other site
1049565014545	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1049565014546	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1049565014547	DNA binding site [nucleotide binding]
1049565014548	domain linker motif; other site
1049565014549	Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283
1049565014550	putative dimerization interface [polypeptide binding]; other site
1049565014551	putative ligand binding site [chemical binding]; other site
1049565014552	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1049565014553	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1049565014554	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1049565014555	substrate binding site [chemical binding]; other site
1049565014556	ATP binding site [chemical binding]; other site
1049565014557	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565014558	D-galactonate transporter; Region: 2A0114; TIGR00893
1049565014559	putative substrate translocation pore; other site
1049565014560	bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409
1049565014561	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
1049565014562	dimerization interface [polypeptide binding]; other site
1049565014563	ligand binding site [chemical binding]; other site
1049565014564	NADP binding site [chemical binding]; other site
1049565014565	catalytic site [active]
1049565014566	Protein of unknown function (DUF3053); Region: DUF3053; pfam11254
1049565014567	benzoate transport; Region: 2A0115; TIGR00895
1049565014568	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565014569	putative substrate translocation pore; other site
1049565014570	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565014571	Predicted transcriptional regulator [Transcription]; Region: COG2944
1049565014572	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1049565014573	salt bridge; other site
1049565014574	non-specific DNA binding site [nucleotide binding]; other site
1049565014575	sequence-specific DNA binding site [nucleotide binding]; other site
1049565014576	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1049565014577	DNA-binding site [nucleotide binding]; DNA binding site
1049565014578	RNA-binding motif; other site
1049565014579	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1049565014580	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1049565014581	Walker A/P-loop; other site
1049565014582	ATP binding site [chemical binding]; other site
1049565014583	Q-loop/lid; other site
1049565014584	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1049565014585	ABC transporter signature motif; other site
1049565014586	Walker B; other site
1049565014587	D-loop; other site
1049565014588	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1049565014589	Hok/gef family; Region: HOK_GEF; cl11494
1049565014590	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
1049565014591	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
1049565014592	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828
1049565014593	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1049565014594	HTH-like domain; Region: HTH_21; pfam13276
1049565014595	Integrase core domain; Region: rve; pfam00665
1049565014596	Integrase core domain; Region: rve_2; pfam13333
1049565014597	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1049565014598	Helix-turn-helix domain; Region: HTH_28; pfam13518
1049565014599	Helix-turn-helix domain; Region: HTH_28; pfam13518
1049565014600	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
1049565014601	DALR anticodon binding domain; Region: DALR_1; pfam05746
1049565014602	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
1049565014603	dimer interface [polypeptide binding]; other site
1049565014604	motif 1; other site
1049565014605	active site
1049565014606	motif 2; other site
1049565014607	motif 3; other site
1049565014608	YsaB-like lipoprotein; Region: YsaB; pfam13983
1049565014609	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
1049565014610	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1049565014611	hypothetical protein; Provisional; Region: PRK11383
1049565014612	yiaA/B two helix domain; Region: YiaAB; pfam05360
1049565014613	yiaA/B two helix domain; Region: YiaAB; pfam05360
1049565014614	hypothetical protein; Provisional; Region: PRK11403
1049565014615	yiaA/B two helix domain; Region: YiaAB; cl01759
1049565014616	xylulokinase; Provisional; Region: PRK15027
1049565014617	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
1049565014618	N- and C-terminal domain interface [polypeptide binding]; other site
1049565014619	active site
1049565014620	MgATP binding site [chemical binding]; other site
1049565014621	catalytic site [active]
1049565014622	metal binding site [ion binding]; metal-binding site
1049565014623	xylulose binding site [chemical binding]; other site
1049565014624	homodimer interface [polypeptide binding]; other site
1049565014625	xylose isomerase; Provisional; Region: PRK05474
1049565014626	xylose isomerase; Region: xylose_isom_A; TIGR02630
1049565014627	D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355
1049565014628	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
1049565014629	putative ligand binding site [chemical binding]; other site
1049565014630	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
1049565014631	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1049565014632	Walker A/P-loop; other site
1049565014633	ATP binding site [chemical binding]; other site
1049565014634	Q-loop/lid; other site
1049565014635	ABC transporter signature motif; other site
1049565014636	Walker B; other site
1049565014637	D-loop; other site
1049565014638	H-loop/switch region; other site
1049565014639	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1049565014640	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1049565014641	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1049565014642	TM-ABC transporter signature motif; other site
1049565014643	Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543
1049565014644	putative dimerization interface [polypeptide binding]; other site
1049565014645	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1049565014646	putative ligand binding site [chemical binding]; other site
1049565014647	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565014648	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1049565014649	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565014650	Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992
1049565014651	hypothetical protein; Provisional; Region: PRK10356
1049565014652	alpha-amylase; Reviewed; Region: malS; PRK09505
1049565014653	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
1049565014654	active site
1049565014655	catalytic site [active]
1049565014656	valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440
1049565014657	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1049565014658	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565014659	homodimer interface [polypeptide binding]; other site
1049565014660	catalytic residue [active]
1049565014661	formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330
1049565014662	selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512
1049565014663	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
1049565014664	G1 box; other site
1049565014665	putative GEF interaction site [polypeptide binding]; other site
1049565014666	GTP/Mg2+ binding site [chemical binding]; other site
1049565014667	Switch I region; other site
1049565014668	G2 box; other site
1049565014669	G3 box; other site
1049565014670	Switch II region; other site
1049565014671	G4 box; other site
1049565014672	G5 box; other site
1049565014673	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
1049565014674	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
1049565014675	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
1049565014676	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
1049565014677	selenocysteine synthase; Provisional; Region: PRK04311
1049565014678	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
1049565014679	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
1049565014680	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1049565014681	catalytic residue [active]
1049565014682	putative glutathione S-transferase; Provisional; Region: PRK10357
1049565014683	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
1049565014684	putative C-terminal domain interface [polypeptide binding]; other site
1049565014685	putative GSH binding site (G-site) [chemical binding]; other site
1049565014686	putative dimer interface [polypeptide binding]; other site
1049565014687	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
1049565014688	dimer interface [polypeptide binding]; other site
1049565014689	N-terminal domain interface [polypeptide binding]; other site
1049565014690	putative substrate binding pocket (H-site) [chemical binding]; other site
1049565014691	PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083
1049565014692	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
1049565014693	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
1049565014694	active site
1049565014695	P-loop; other site
1049565014696	phosphorylation site [posttranslational modification]
1049565014697	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1049565014698	active site
1049565014699	phosphorylation site [posttranslational modification]
1049565014700	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
1049565014701	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1049565014702	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1049565014703	Transcriptional regulator [Transcription]; Region: MtlR; COG3722
1049565014704	mannitol repressor protein; Provisional; Region: mtlR; PRK11001
1049565014705	Glycogen synthesis protein; Region: GlgS; cl11663
1049565014706	hypothetical protein; Provisional; Region: PRK11020
1049565014707	L-lactate permease; Provisional; Region: PRK10420
1049565014708	glycolate transporter; Provisional; Region: PRK09695
1049565014709	DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421
1049565014710	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1049565014711	DNA-binding site [nucleotide binding]; DNA binding site
1049565014712	FCD domain; Region: FCD; pfam07729
1049565014713	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
1049565014714	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
1049565014715	active site
1049565014716	substrate binding site [chemical binding]; other site
1049565014717	FMN binding site [chemical binding]; other site
1049565014718	putative catalytic residues [active]
1049565014719	putative rRNA methylase; Provisional; Region: PRK10358
1049565014720	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1049565014721	Helix-turn-helix domain; Region: HTH_28; pfam13518
1049565014722	Helix-turn-helix domain; Region: HTH_28; pfam13518
1049565014723	putative transposase OrfB; Reviewed; Region: PHA02517
1049565014724	HTH-like domain; Region: HTH_21; pfam13276
1049565014725	Integrase core domain; Region: rve; pfam00665
1049565014726	Integrase core domain; Region: rve_2; pfam13333
1049565014727	serine acetyltransferase; Provisional; Region: cysE; PRK11132
1049565014728	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
1049565014729	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1049565014730	trimer interface [polypeptide binding]; other site
1049565014731	active site
1049565014732	substrate binding site [chemical binding]; other site
1049565014733	CoA binding site [chemical binding]; other site
1049565014734	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1049565014735	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1049565014736	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1049565014737	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557
1049565014738	SecA binding site; other site
1049565014739	Preprotein binding site; other site
1049565014740	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
1049565014741	GSH binding site [chemical binding]; other site
1049565014742	catalytic residues [active]
1049565014743	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1049565014744	active site residue [active]
1049565014745	phosphoglyceromutase; Provisional; Region: PRK05434
1049565014746	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307
1049565014747	AmiB activator; Provisional; Region: PRK11637
1049565014748	Vps51/Vps67; Region: Vps51; pfam08700
1049565014749	Peptidase family M23; Region: Peptidase_M23; pfam01551
1049565014750	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
1049565014751	NodB motif; other site
1049565014752	putative active site [active]
1049565014753	putative catalytic site [active]
1049565014754	Zn binding site [ion binding]; other site
1049565014755	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1049565014756	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
1049565014757	putative metal binding site; other site
1049565014758	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
1049565014759	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1049565014760	NAD(P) binding site [chemical binding]; other site
1049565014761	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1049565014762	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
1049565014763	substrate-cofactor binding pocket; other site
1049565014764	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565014765	catalytic residue [active]
1049565014766	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
1049565014767	ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150
1049565014768	NADP binding site [chemical binding]; other site
1049565014769	homopentamer interface [polypeptide binding]; other site
1049565014770	substrate binding site [chemical binding]; other site
1049565014771	active site
1049565014772	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1049565014773	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1049565014774	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1049565014775	putative active site [active]
1049565014776	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1049565014777	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1049565014778	putative active site [active]
1049565014779	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1049565014780	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1049565014781	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
1049565014782	O-Antigen ligase; Region: Wzy_C; pfam04932
1049565014783	putative glycosyl transferase; Provisional; Region: PRK10073
1049565014784	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1049565014785	active site
1049565014786	Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935
1049565014787	putative active site [active]
1049565014788	putative catalytic site [active]
1049565014789	lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422
1049565014790	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1049565014791	putative active site [active]
1049565014792	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1049565014793	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1049565014794	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1049565014795	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
1049565014796	putative ADP-binding pocket [chemical binding]; other site
1049565014797	putative glycosyl transferase; Provisional; Region: PRK10073
1049565014798	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1049565014799	active site
1049565014800	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
1049565014801	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
1049565014802	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1049565014803	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1049565014804	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
1049565014805	putative metal binding site; other site
1049565014806	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1049565014807	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1049565014808	active site
1049565014809	(T/H)XGH motif; other site
1049565014810	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
1049565014811	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1049565014812	DNA binding site [nucleotide binding]
1049565014813	catalytic residue [active]
1049565014814	H2TH interface [polypeptide binding]; other site
1049565014815	putative catalytic residues [active]
1049565014816	turnover-facilitating residue; other site
1049565014817	intercalation triad [nucleotide binding]; other site
1049565014818	8OG recognition residue [nucleotide binding]; other site
1049565014819	putative reading head residues; other site
1049565014820	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1049565014821	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1049565014822	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
1049565014823	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1049565014824	hypothetical protein; Reviewed; Region: PRK00024
1049565014825	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1049565014826	MPN+ (JAMM) motif; other site
1049565014827	Zinc-binding site [ion binding]; other site
1049565014828	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
1049565014829	Flavoprotein; Region: Flavoprotein; pfam02441
1049565014830	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
1049565014831	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1049565014832	trimer interface [polypeptide binding]; other site
1049565014833	active site
1049565014834	division inhibitor protein; Provisional; Region: slmA; PRK09480
1049565014835	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1049565014836	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
1049565014837	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1049565014838	active site
1049565014839	ribonuclease PH; Reviewed; Region: rph; PRK00173
1049565014840	Ribonuclease PH; Region: RNase_PH_bact; cd11362
1049565014841	hexamer interface [polypeptide binding]; other site
1049565014842	active site
1049565014843	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1049565014844	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1049565014845	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1049565014846	potential frameshift: common BLAST hit: gi|152972492|ref|YP_001337638.1| putative ABC-type multidrug transport system, ATPase component
1049565014847	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
1049565014848	HlyD family secretion protein; Region: HlyD_3; pfam13437
1049565014849	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986
1049565014850	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1049565014851	putative acyl-acceptor binding pocket; other site
1049565014852	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
1049565014853	hypothetical protein; Provisional; Region: PRK11820
1049565014854	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
1049565014855	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
1049565014856	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
1049565014857	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1049565014858	tetramer interface [polypeptide binding]; other site
1049565014859	active site
1049565014860	Mg2+/Mn2+ binding site [ion binding]; other site
1049565014861	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
1049565014862	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
1049565014863	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
1049565014864	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1049565014865	DNA binding site [nucleotide binding]
1049565014866	active site
1049565014867	Putative ClC chloride channel.  Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033
1049565014868	putative ion selectivity filter; other site
1049565014869	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1049565014870	putative pore gating glutamate residue; other site
1049565014871	Predicted membrane protein [Function unknown]; Region: COG2860
1049565014872	UPF0126 domain; Region: UPF0126; pfam03458
1049565014873	UPF0126 domain; Region: UPF0126; pfam03458
1049565014874	NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097
1049565014875	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295
1049565014876	nucleotide binding pocket [chemical binding]; other site
1049565014877	K-X-D-G motif; other site
1049565014878	catalytic site [active]
1049565014879	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1049565014880	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1049565014881	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1049565014882	catalytic site [active]
1049565014883	G-X2-G-X-G-K; other site
1049565014884	DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690
1049565014885	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
1049565014886	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1049565014887	Zn2+ binding site [ion binding]; other site
1049565014888	Mg2+ binding site [ion binding]; other site
1049565014889	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1049565014890	synthetase active site [active]
1049565014891	NTP binding site [chemical binding]; other site
1049565014892	metal binding site [ion binding]; metal-binding site
1049565014893	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1049565014894	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1049565014895	tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081
1049565014896	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1049565014897	SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105
1049565014898	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
1049565014899	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1049565014900	generic binding surface II; other site
1049565014901	ssDNA binding site; other site
1049565014902	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1049565014903	ATP binding site [chemical binding]; other site
1049565014904	putative Mg++ binding site [ion binding]; other site
1049565014905	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1049565014906	nucleotide binding region [chemical binding]; other site
1049565014907	ATP-binding site [chemical binding]; other site
1049565014908	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
1049565014909	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
1049565014910	putative active site [active]
1049565014911	ferredoxin-NADP reductase; Provisional; Region: PRK10926
1049565014912	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
1049565014913	FAD binding pocket [chemical binding]; other site
1049565014914	FAD binding motif [chemical binding]; other site
1049565014915	phosphate binding motif [ion binding]; other site
1049565014916	beta-alpha-beta structure motif; other site
1049565014917	NAD binding pocket [chemical binding]; other site
1049565014918	Predicted membrane protein [Function unknown]; Region: COG3152
1049565014919	Protein of unknown function (DUF1454); Region: DUF1454; pfam07305
1049565014920	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1049565014921	triosephosphate isomerase; Provisional; Region: PRK14567
1049565014922	substrate binding site [chemical binding]; other site
1049565014923	dimer interface [polypeptide binding]; other site
1049565014924	catalytic triad [active]
1049565014925	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1049565014926	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1049565014927	transmembrane helices; other site
1049565014928	CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471
1049565014929	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1049565014930	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1049565014931	substrate binding pocket [chemical binding]; other site
1049565014932	membrane-bound complex binding site; other site
1049565014933	septal ring assembly protein ZapB; Provisional; Region: PRK15422
1049565014934	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
1049565014935	amphipathic channel; other site
1049565014936	Asn-Pro-Ala signature motifs; other site
1049565014937	glycerol kinase; Provisional; Region: glpK; PRK00047
1049565014938	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
1049565014939	N- and C-terminal domain interface [polypeptide binding]; other site
1049565014940	active site
1049565014941	MgATP binding site [chemical binding]; other site
1049565014942	catalytic site [active]
1049565014943	metal binding site [ion binding]; metal-binding site
1049565014944	glycerol binding site [chemical binding]; other site
1049565014945	homotetramer interface [polypeptide binding]; other site
1049565014946	homodimer interface [polypeptide binding]; other site
1049565014947	FBP binding site [chemical binding]; other site
1049565014948	protein IIAGlc interface [polypeptide binding]; other site
1049565014949	sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210
1049565014950	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
1049565014951	AsmA family; Region: AsmA; pfam05170
1049565014952	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1049565014953	PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005
1049565014954	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1049565014955	active site turn [active]
1049565014956	phosphorylation site [posttranslational modification]
1049565014957	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
1049565014958	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
1049565014959	NAD(P) binding site [chemical binding]; other site
1049565014960	LDH/MDH dimer interface [polypeptide binding]; other site
1049565014961	substrate binding site [chemical binding]; other site
1049565014962	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1049565014963	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1049565014964	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1049565014965	putative active site [active]
1049565014966	putative alpha-glucosidase; Provisional; Region: PRK10658
1049565014967	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
1049565014968	YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593
1049565014969	active site
1049565014970	homotrimer interface [polypeptide binding]; other site
1049565014971	catalytic site [active]
1049565014972	homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site
1049565014973	putative transporter; Provisional; Region: PRK11462
1049565014974	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
1049565014975	potential RNA location (tRNA-U) that overlaps protein (putative transposase [Klebsiella pneumoniae KCTC 2242])
1049565014976	Protein of unknown function (DUF3237); Region: DUF3237; pfam11578
1049565014977	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
1049565014978	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
1049565014979	putative NAD(P) binding site [chemical binding]; other site
1049565014980	dimer interface [polypeptide binding]; other site
1049565014981	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1049565014982	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832
1049565014983	Transcriptional regulator; Region: Rrf2; cl17282
1049565014984	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1049565014985	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
1049565014986	putative NAD(P) binding site [chemical binding]; other site
1049565014987	putative substrate binding site [chemical binding]; other site
1049565014988	catalytic Zn binding site [ion binding]; other site
1049565014989	structural Zn binding site [ion binding]; other site
1049565014990	dimer interface [polypeptide binding]; other site
1049565014991	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
1049565014992	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
1049565014993	conserved cys residue [active]
1049565014994	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565014995	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565014996	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1049565014997	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
1049565014998	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
1049565014999	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1049565015000	dimer interface [polypeptide binding]; other site
1049565015001	ADP-ribose binding site [chemical binding]; other site
1049565015002	active site
1049565015003	nudix motif; other site
1049565015004	metal binding site [ion binding]; metal-binding site
1049565015005	EamA-like transporter family; Region: EamA; pfam00892
1049565015006	cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861
1049565015007	lipoprotein, YaeC family; Region: TIGR00363
1049565015008	Cupin; Region: Cupin_6; pfam12852
1049565015009	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565015010	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1049565015011	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565015012	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
1049565015013	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1049565015014	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
1049565015015	SnoaL-like domain; Region: SnoaL_2; pfam12680
1049565015016	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
1049565015017	transcriptional regulator; Provisional; Region: PRK10632
1049565015018	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565015019	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471
1049565015020	putative effector binding pocket; other site
1049565015021	putative dimerization interface [polypeptide binding]; other site
1049565015022	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1049565015023	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565015024	putative substrate translocation pore; other site
1049565015025	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1049565015026	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1049565015027	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1049565015028	Coenzyme A binding pocket [chemical binding]; other site
1049565015029	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1049565015030	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1049565015031	HlyD family secretion protein; Region: HlyD_3; pfam13437
1049565015032	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
1049565015033	Protein export membrane protein; Region: SecD_SecF; cl14618
1049565015034	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
1049565015035	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565015036	putative substrate translocation pore; other site
1049565015037	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
1049565015038	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
1049565015039	putative active site [active]
1049565015040	PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586
1049565015041	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1049565015042	active site turn [active]
1049565015043	phosphorylation site [posttranslational modification]
1049565015044	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1049565015045	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1049565015046	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1049565015047	Domain of unknown function (DUF1932); Region: DUF1932; pfam09130
1049565015048	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828
1049565015049	hypothetical protein; Provisional; Region: PRK09262
1049565015050	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
1049565015051	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565015052	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565015053	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
1049565015054	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565015055	The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435
1049565015056	putative dimerization interface [polypeptide binding]; other site
1049565015057	potential frameshift: common BLAST hit: gi|288932933|ref|YP_003436992.1| extradiol ring-cleavage dioxygenase class III protein subunit B
1049565015058	benzoate transport; Region: 2A0115; TIGR00895
1049565015059	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565015060	putative substrate translocation pore; other site
1049565015061	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1049565015062	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1049565015063	DNA binding site [nucleotide binding]
1049565015064	domain linker motif; other site
1049565015065	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1049565015066	ligand binding site [chemical binding]; other site
1049565015067	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
1049565015068	active site
1049565015069	P-loop; other site
1049565015070	phosphorylation site [posttranslational modification]
1049565015071	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1049565015072	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1049565015073	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
1049565015074	methionine cluster; other site
1049565015075	active site
1049565015076	phosphorylation site [posttranslational modification]
1049565015077	metal binding site [ion binding]; metal-binding site
1049565015078	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1049565015079	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1049565015080	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565015081	dimer interface [polypeptide binding]; other site
1049565015082	conserved gate region; other site
1049565015083	putative PBP binding loops; other site
1049565015084	ABC-ATPase subunit interface; other site
1049565015085	2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050
1049565015086	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565015087	dimer interface [polypeptide binding]; other site
1049565015088	conserved gate region; other site
1049565015089	putative PBP binding loops; other site
1049565015090	ABC-ATPase subunit interface; other site
1049565015091	2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; Region: PhnT; TIGR03258
1049565015092	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1049565015093	Walker A/P-loop; other site
1049565015094	ATP binding site [chemical binding]; other site
1049565015095	Q-loop/lid; other site
1049565015096	ABC transporter signature motif; other site
1049565015097	Walker B; other site
1049565015098	D-loop; other site
1049565015099	H-loop/switch region; other site
1049565015100	TOBE domain; Region: TOBE_2; pfam08402
1049565015101	2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046
1049565015102	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1049565015103	transcriptional regulator protein; Region: phnR; TIGR03337
1049565015104	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1049565015105	DNA-binding site [nucleotide binding]; DNA binding site
1049565015106	UTRA domain; Region: UTRA; pfam07702
1049565015107	2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479
1049565015108	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1049565015109	catalytic residue [active]
1049565015110	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
1049565015111	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1049565015112	motif II; other site
1049565015113	ribonucleoside transporter; Reviewed; Region: nepI; PRK10213
1049565015114	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565015115	putative substrate translocation pore; other site
1049565015116	Protein of unknown function (DUF1044); Region: DUF1044; pfam06296
1049565015117	Predicted transcriptional regulator [Transcription]; Region: COG2944
1049565015118	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1049565015119	non-specific DNA binding site [nucleotide binding]; other site
1049565015120	salt bridge; other site
1049565015121	sequence-specific DNA binding site [nucleotide binding]; other site
1049565015122	Protein of unknown function (DUF1198); Region: DUF1198; pfam06711
1049565015123	sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556
1049565015124	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565015125	putative substrate translocation pore; other site
1049565015126	regulatory protein UhpC; Provisional; Region: PRK11663
1049565015127	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565015128	putative substrate translocation pore; other site
1049565015129	sensory histidine kinase UhpB; Provisional; Region: PRK11644
1049565015130	MASE1; Region: MASE1; pfam05231
1049565015131	Histidine kinase; Region: HisKA_3; pfam07730
1049565015132	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1049565015133	ATP binding site [chemical binding]; other site
1049565015134	Mg2+ binding site [ion binding]; other site
1049565015135	G-X-G motif; other site
1049565015136	DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360
1049565015137	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1049565015138	active site
1049565015139	phosphorylation site [posttranslational modification]
1049565015140	intermolecular recognition site; other site
1049565015141	dimerization interface [polypeptide binding]; other site
1049565015142	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1049565015143	DNA binding residues [nucleotide binding]
1049565015144	dimerization interface [polypeptide binding]; other site
1049565015145	Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440
1049565015146	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
1049565015147	putative valine binding site [chemical binding]; other site
1049565015148	dimer interface [polypeptide binding]; other site
1049565015149	acetolactate synthase catalytic subunit; Validated; Region: PRK08155
1049565015150	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1049565015151	PYR/PP interface [polypeptide binding]; other site
1049565015152	dimer interface [polypeptide binding]; other site
1049565015153	TPP binding site [chemical binding]; other site
1049565015154	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1049565015155	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1049565015156	TPP-binding site [chemical binding]; other site
1049565015157	dimer interface [polypeptide binding]; other site
1049565015158	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1049565015159	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1049565015160	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1049565015161	Coenzyme A binding pocket [chemical binding]; other site
1049565015162	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
1049565015163	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
1049565015164	multidrug resistance protein D; Provisional; Region: emrD; PRK11652
1049565015165	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565015166	putative substrate translocation pore; other site
1049565015167	DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086
1049565015168	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565015169	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1049565015170	dimerization interface [polypeptide binding]; other site
1049565015171	substrate binding pocket [chemical binding]; other site
1049565015172	permease DsdX; Provisional; Region: PRK09921
1049565015173	GntP family permease; Region: GntP_permease; pfam02447
1049565015174	D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine  to pyruvate and ammonia.  D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447
1049565015175	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
1049565015176	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1049565015177	catalytic residue [active]
1049565015178	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
1049565015179	Domain of unknown function (DUF202); Region: DUF202; pfam02656
1049565015180	Predicted membrane protein [Function unknown]; Region: COG2149
1049565015181	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
1049565015182	Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298
1049565015183	NAD binding site [chemical binding]; other site
1049565015184	sugar binding site [chemical binding]; other site
1049565015185	divalent metal binding site [ion binding]; other site
1049565015186	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
1049565015187	dimer interface [polypeptide binding]; other site
1049565015188	PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005
1049565015189	PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852
1049565015190	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1049565015191	active site turn [active]
1049565015192	phosphorylation site [posttranslational modification]
1049565015193	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1049565015194	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1049565015195	DNA-binding site [nucleotide binding]; DNA binding site
1049565015196	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1049565015197	putative transporter; Validated; Region: PRK03818
1049565015198	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
1049565015199	TrkA-C domain; Region: TrkA_C; pfam02080
1049565015200	TrkA-C domain; Region: TrkA_C; pfam02080
1049565015201	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
1049565015202	potential frameshift: common BLAST hit: gi|238897196|ref|YP_002921944.1| DNA-damage-inducible protein D
1049565015203	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1049565015204	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
1049565015205	putative dimer interface [polypeptide binding]; other site
1049565015206	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1049565015207	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
1049565015208	putative dimer interface [polypeptide binding]; other site
1049565015209	hypothetical protein; Provisional; Region: PRK11616
1049565015210	Protein of unknown function (DUF3748); Region: DUF3748; pfam12566
1049565015211	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1049565015212	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565015213	D-galactonate transporter; Region: 2A0114; TIGR00893
1049565015214	putative substrate translocation pore; other site
1049565015215	galactonate dehydratase; Provisional; Region: PRK14017
1049565015216	D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325
1049565015217	putative active site pocket [active]
1049565015218	putative metal binding site [ion binding]; other site
1049565015219	2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140
1049565015220	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
1049565015221	active site
1049565015222	intersubunit interface [polypeptide binding]; other site
1049565015223	catalytic residue [active]
1049565015224	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
1049565015225	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
1049565015226	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1049565015227	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1049565015228	DNA-binding site [nucleotide binding]; DNA binding site
1049565015229	FCD domain; Region: FCD; pfam07729
1049565015230	Surface antigen; Region: Bac_surface_Ag; pfam01103
1049565015231	sugar phosphate phosphatase; Provisional; Region: PRK10513
1049565015232	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1049565015233	active site
1049565015234	motif I; other site
1049565015235	motif II; other site
1049565015236	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1049565015237	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
1049565015238	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1049565015239	Mg2+ binding site [ion binding]; other site
1049565015240	G-X-G motif; other site
1049565015241	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1049565015242	anchoring element; other site
1049565015243	dimer interface [polypeptide binding]; other site
1049565015244	ATP binding site [chemical binding]; other site
1049565015245	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1049565015246	active site
1049565015247	putative metal-binding site [ion binding]; other site
1049565015248	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1049565015249	recF protein; Region: recf; TIGR00611
1049565015250	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1049565015251	Walker A/P-loop; other site
1049565015252	ATP binding site [chemical binding]; other site
1049565015253	Q-loop/lid; other site
1049565015254	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1049565015255	ABC transporter signature motif; other site
1049565015256	Walker B; other site
1049565015257	D-loop; other site
1049565015258	H-loop/switch region; other site
1049565015259	DNA polymerase III subunit beta; Validated; Region: PRK05643
1049565015260	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1049565015261	putative DNA binding surface [nucleotide binding]; other site
1049565015262	dimer interface [polypeptide binding]; other site
1049565015263	beta-clamp/clamp loader binding surface; other site
1049565015264	beta-clamp/translesion DNA polymerase binding surface; other site
1049565015265	DnaA N-terminal domain; Region: DnaA_N; pfam11638
1049565015266	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
1049565015267	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1049565015268	Walker A motif; other site
1049565015269	ATP binding site [chemical binding]; other site
1049565015270	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1049565015271	Walker B motif; other site
1049565015272	arginine finger; other site
1049565015273	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1049565015274	DnaA box-binding interface [nucleotide binding]; other site
1049565015275	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
1049565015276	ribonuclease P; Reviewed; Region: rnpA; PRK01732
1049565015277	hypothetical protein; Validated; Region: PRK00041
1049565015278	membrane protein insertase; Provisional; Region: PRK01318
1049565015279	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
1049565015280	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
1049565015281	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
1049565015282	trmE is a tRNA modification GTPase; Region: trmE; cd04164
1049565015283	G1 box; other site
1049565015284	GTP/Mg2+ binding site [chemical binding]; other site
1049565015285	Switch I region; other site
1049565015286	G2 box; other site
1049565015287	Switch II region; other site
1049565015288	G3 box; other site
1049565015289	G4 box; other site
1049565015290	G5 box; other site
1049565015291	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
1049565015292	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1049565015293	Coenzyme A binding pocket [chemical binding]; other site
1049565015294	multidrug efflux system protein MdtL; Provisional; Region: PRK10473
1049565015295	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565015296	putative substrate translocation pore; other site
1049565015297	DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216
1049565015298	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565015299	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
1049565015300	substrate binding pocket [chemical binding]; other site
1049565015301	dimerization interface [polypeptide binding]; other site
1049565015302	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
1049565015303	Predicted flavoprotein [General function prediction only]; Region: COG0431
1049565015304	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1049565015305	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1049565015306	6-phosphogluconate phosphatase; Provisional; Region: PRK10563
1049565015307	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1049565015308	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1049565015309	motif II; other site
1049565015310	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1049565015311	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
1049565015312	active site
1049565015313	trimer interface [polypeptide binding]; other site
1049565015314	allosteric site; other site
1049565015315	active site lid [active]
1049565015316	hexamer (dimer of trimers) interface [polypeptide binding]; other site
1049565015317	N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294
1049565015318	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
1049565015319	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1049565015320	Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471
1049565015321	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
1049565015322	trimer interface; other site
1049565015323	sugar binding site [chemical binding]; other site
1049565015324	transcriptional regulator PhoU; Provisional; Region: PRK11115
1049565015325	PhoU domain; Region: PhoU; pfam01895
1049565015326	PhoU domain; Region: PhoU; pfam01895
1049565015327	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
1049565015328	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1049565015329	Walker A/P-loop; other site
1049565015330	ATP binding site [chemical binding]; other site
1049565015331	Q-loop/lid; other site
1049565015332	ABC transporter signature motif; other site
1049565015333	Walker B; other site
1049565015334	D-loop; other site
1049565015335	H-loop/switch region; other site
1049565015336	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
1049565015337	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565015338	dimer interface [polypeptide binding]; other site
1049565015339	conserved gate region; other site
1049565015340	putative PBP binding loops; other site
1049565015341	ABC-ATPase subunit interface; other site
1049565015342	phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275
1049565015343	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1049565015344	dimer interface [polypeptide binding]; other site
1049565015345	conserved gate region; other site
1049565015346	putative PBP binding loops; other site
1049565015347	ABC-ATPase subunit interface; other site
1049565015348	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1049565015349	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1049565015350	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1049565015351	glutaminase active site [active]
1049565015352	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1049565015353	dimer interface [polypeptide binding]; other site
1049565015354	active site
1049565015355	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1049565015356	dimer interface [polypeptide binding]; other site
1049565015357	active site
1049565015358	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451
1049565015359	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1049565015360	Substrate binding site; other site
1049565015361	Mg++ binding site; other site
1049565015362	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1049565015363	active site
1049565015364	substrate binding site [chemical binding]; other site
1049565015365	CoA binding site [chemical binding]; other site
1049565015366	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
1049565015367	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1049565015368	gamma subunit interface [polypeptide binding]; other site
1049565015369	epsilon subunit interface [polypeptide binding]; other site
1049565015370	LBP interface [polypeptide binding]; other site
1049565015371	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1049565015372	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1049565015373	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1049565015374	alpha subunit interaction interface [polypeptide binding]; other site
1049565015375	Walker A motif; other site
1049565015376	ATP binding site [chemical binding]; other site
1049565015377	Walker B motif; other site
1049565015378	inhibitor binding site; inhibition site
1049565015379	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1049565015380	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1049565015381	core domain interface [polypeptide binding]; other site
1049565015382	delta subunit interface [polypeptide binding]; other site
1049565015383	epsilon subunit interface [polypeptide binding]; other site
1049565015384	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1049565015385	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1049565015386	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1049565015387	beta subunit interaction interface [polypeptide binding]; other site
1049565015388	Walker A motif; other site
1049565015389	ATP binding site [chemical binding]; other site
1049565015390	Walker B motif; other site
1049565015391	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1049565015392	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
1049565015393	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
1049565015394	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
1049565015395	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
1049565015396	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
1049565015397	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
1049565015398	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1049565015399	F0F1 ATP synthase subunit I; Validated; Region: PRK08049
1049565015400	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
1049565015401	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1049565015402	S-adenosylmethionine binding site [chemical binding]; other site
1049565015403	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
1049565015404	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
1049565015405	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
1049565015406	FMN-binding protein MioC; Provisional; Region: PRK09004
1049565015407	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
1049565015408	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1049565015409	putative DNA binding site [nucleotide binding]; other site
1049565015410	putative Zn2+ binding site [ion binding]; other site
1049565015411	AsnC family; Region: AsnC_trans_reg; pfam01037
1049565015412	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
1049565015413	dimer interface [polypeptide binding]; other site
1049565015414	active site
1049565015415	hypothetical protein; Provisional; Region: yieM; PRK10997
1049565015416	VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462
1049565015417	metal ion-dependent adhesion site (MIDAS); other site
1049565015418	regulatory ATPase RavA; Provisional; Region: PRK13531
1049565015419	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1049565015420	Walker A motif; other site
1049565015421	ATP binding site [chemical binding]; other site
1049565015422	Walker B motif; other site
1049565015423	arginine finger; other site
1049565015424	Protein of unknown function (DUF3763); Region: DUF3763; pfam12592
1049565015425	potassium transport protein Kup; Provisional; Region: trkD; PRK10745
1049565015426	potassium uptake protein; Region: kup; TIGR00794
1049565015427	D-ribose pyranase; Provisional; Region: PRK11797
1049565015428	D-ribose transporter ATP binding protein; Provisional; Region: PRK10762
1049565015429	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1049565015430	Walker A/P-loop; other site
1049565015431	ATP binding site [chemical binding]; other site
1049565015432	Q-loop/lid; other site
1049565015433	ABC transporter signature motif; other site
1049565015434	Walker B; other site
1049565015435	D-loop; other site
1049565015436	H-loop/switch region; other site
1049565015437	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1049565015438	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1049565015439	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1049565015440	TM-ABC transporter signature motif; other site
1049565015441	D-ribose transporter subunit RbsB; Provisional; Region: PRK10653
1049565015442	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
1049565015443	ligand binding site [chemical binding]; other site
1049565015444	dimerization interface [polypeptide binding]; other site
1049565015445	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1049565015446	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1049565015447	substrate binding site [chemical binding]; other site
1049565015448	dimer interface [polypeptide binding]; other site
1049565015449	ATP binding site [chemical binding]; other site
1049565015450	transcriptional repressor RbsR; Provisional; Region: PRK10423
1049565015451	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1049565015452	DNA binding site [nucleotide binding]
1049565015453	domain linker motif; other site
1049565015454	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
1049565015455	dimerization interface [polypeptide binding]; other site
1049565015456	ligand binding site [chemical binding]; other site
1049565015457	putative transporter; Provisional; Region: PRK10504
1049565015458	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565015459	putative substrate translocation pore; other site
1049565015460	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1049565015461	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1049565015462	DNA-binding site [nucleotide binding]; DNA binding site
1049565015463	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1049565015464	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
1049565015465	Walker A motif; other site
1049565015466	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
1049565015467	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
1049565015468	GTP binding site; other site
1049565015469	Protein of unknown function (DUF1040); Region: DUF1040; pfam06288
1049565015470	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
1049565015471	serine/threonine protein kinase; Provisional; Region: PRK11768
1049565015472	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
1049565015473	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1049565015474	catalytic residues [active]
1049565015475	hinge region; other site
1049565015476	alpha helical domain; other site
1049565015477	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1049565015478	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
1049565015479	putative acyl-acceptor binding pocket; other site
1049565015480	DNA polymerase I; Provisional; Region: PRK05755
1049565015481	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1049565015482	active site
1049565015483	metal binding site 1 [ion binding]; metal-binding site
1049565015484	putative 5' ssDNA interaction site; other site
1049565015485	metal binding site 3; metal-binding site
1049565015486	metal binding site 2 [ion binding]; metal-binding site
1049565015487	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1049565015488	putative DNA binding site [nucleotide binding]; other site
1049565015489	putative metal binding site [ion binding]; other site
1049565015490	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
1049565015491	active site
1049565015492	catalytic site [active]
1049565015493	substrate binding site [chemical binding]; other site
1049565015494	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1049565015495	active site
1049565015496	DNA binding site [nucleotide binding]
1049565015497	catalytic site [active]
1049565015498	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
1049565015499	G1 box; other site
1049565015500	GTP/Mg2+ binding site [chemical binding]; other site
1049565015501	Switch I region; other site
1049565015502	G2 box; other site
1049565015503	G3 box; other site
1049565015504	Switch II region; other site
1049565015505	G4 box; other site
1049565015506	G5 box; other site
1049565015507	Der GTPase activator; Provisional; Region: PRK05244
1049565015508	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
1049565015509	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1049565015510	FeS/SAM binding site; other site
1049565015511	HemN C-terminal domain; Region: HemN_C; pfam06969
1049565015512	nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923
1049565015513	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1049565015514	active site
1049565015515	phosphorylation site [posttranslational modification]
1049565015516	intermolecular recognition site; other site
1049565015517	dimerization interface [polypeptide binding]; other site
1049565015518	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1049565015519	Walker A motif; other site
1049565015520	ATP binding site [chemical binding]; other site
1049565015521	Walker B motif; other site
1049565015522	arginine finger; other site
1049565015523	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1049565015524	nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073
1049565015525	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1049565015526	putative active site [active]
1049565015527	heme pocket [chemical binding]; other site
1049565015528	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1049565015529	dimer interface [polypeptide binding]; other site
1049565015530	phosphorylation site [posttranslational modification]
1049565015531	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1049565015532	ATP binding site [chemical binding]; other site
1049565015533	Mg2+ binding site [ion binding]; other site
1049565015534	G-X-G motif; other site
1049565015535	glutamine synthetase; Provisional; Region: glnA; PRK09469
1049565015536	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1049565015537	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1049565015538	GTP-binding protein; Provisional; Region: PRK10218
1049565015539	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1049565015540	G1 box; other site
1049565015541	putative GEF interaction site [polypeptide binding]; other site
1049565015542	GTP/Mg2+ binding site [chemical binding]; other site
1049565015543	Switch I region; other site
1049565015544	G2 box; other site
1049565015545	G3 box; other site
1049565015546	Switch II region; other site
1049565015547	G4 box; other site
1049565015548	G5 box; other site
1049565015549	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1049565015550	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1049565015551	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
1049565015552	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1049565015553	motif II; other site
1049565015554	hypothetical protein; Reviewed; Region: PRK01637
1049565015555	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
1049565015556	putative active site [active]
1049565015557	dimerization interface [polypeptide binding]; other site
1049565015558	putative tRNAtyr binding site [nucleotide binding]; other site
1049565015559	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1049565015560	Coenzyme A binding pocket [chemical binding]; other site
1049565015561	Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500
1049565015562	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1049565015563	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1049565015564	substrate binding pocket [chemical binding]; other site
1049565015565	Ribbon-helix-helix domain; Region: RHH_3; pfam12651
1049565015566	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
1049565015567	oligomeric interface; other site
1049565015568	putative active site [active]
1049565015569	homodimer interface [polypeptide binding]; other site
1049565015570	formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564
1049565015571	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
1049565015572	formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639
1049565015573	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
1049565015574	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
1049565015575	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
1049565015576	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1049565015577	molybdopterin cofactor binding site; other site
1049565015578	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
1049565015579	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
1049565015580	molybdopterin cofactor binding site; other site
1049565015581	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1049565015582	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
1049565015583	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
1049565015584	dimerization interface [polypeptide binding]; other site
1049565015585	allosteric effector site; other site
1049565015586	active site
1049565015587	ADP/pyrophosphate binding site [chemical binding]; other site
1049565015588	fructose-1,6-bisphosphate binding site; other site
1049565015589	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
1049565015590	active site
1049565015591	P-loop; other site
1049565015592	phosphorylation site [posttranslational modification]
1049565015593	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997
1049565015594	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1049565015595	intersubunit interface [polypeptide binding]; other site
1049565015596	active site
1049565015597	zinc binding site [ion binding]; other site
1049565015598	Na+ binding site [ion binding]; other site
1049565015599	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1049565015600	active site
1049565015601	phosphorylation site [posttranslational modification]
1049565015602	AAA domain; Region: AAA_18; pfam13238
1049565015603	AAA domain; Region: AAA_17; pfam13207
1049565015604	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
1049565015605	AzlC protein; Region: AzlC; cl00570
1049565015606	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1049565015607	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1049565015608	non-specific DNA binding site [nucleotide binding]; other site
1049565015609	salt bridge; other site
1049565015610	sequence-specific DNA binding site [nucleotide binding]; other site
1049565015611	Cupin domain; Region: Cupin_2; cl17218
1049565015612	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1049565015613	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1049565015614	DNA binding site [nucleotide binding]
1049565015615	domain linker motif; other site
1049565015616	Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271
1049565015617	ligand binding site [chemical binding]; other site
1049565015618	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
1049565015619	Melibiase; Region: Melibiase; pfam02065
1049565015620	galactoside permease; Reviewed; Region: lacY; PRK09528
1049565015621	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565015622	putative substrate translocation pore; other site
1049565015623	L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625
1049565015624	lactaldehyde reductase; Region: lactal_redase; TIGR02638
1049565015625	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
1049565015626	dimer interface [polypeptide binding]; other site
1049565015627	active site
1049565015628	metal binding site [ion binding]; metal-binding site
1049565015629	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1049565015630	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1049565015631	TM-ABC transporter signature motif; other site
1049565015632	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1049565015633	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1049565015634	TM-ABC transporter signature motif; other site
1049565015635	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1049565015636	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1049565015637	Walker A/P-loop; other site
1049565015638	ATP binding site [chemical binding]; other site
1049565015639	Q-loop/lid; other site
1049565015640	ABC transporter signature motif; other site
1049565015641	Walker B; other site
1049565015642	D-loop; other site
1049565015643	H-loop/switch region; other site
1049565015644	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1049565015645	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
1049565015646	rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637
1049565015647	ligand binding site [chemical binding]; other site
1049565015648	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
1049565015649	intersubunit interface [polypeptide binding]; other site
1049565015650	active site
1049565015651	Zn2+ binding site [ion binding]; other site
1049565015652	L-rhamnose isomerase; Provisional; Region: PRK01076
1049565015653	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
1049565015654	N- and C-terminal domain interface [polypeptide binding]; other site
1049565015655	active site
1049565015656	putative catalytic site [active]
1049565015657	metal binding site [ion binding]; metal-binding site
1049565015658	ATP binding site [chemical binding]; other site
1049565015659	rhamnulokinase; Provisional; Region: rhaB; PRK10640
1049565015660	carbohydrate binding site [chemical binding]; other site
1049565015661	transcriptional activator RhaS; Provisional; Region: PRK13503
1049565015662	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1049565015663	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565015664	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565015665	transcriptional activator RhaR; Provisional; Region: PRK13502
1049565015666	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1049565015667	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565015668	L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728
1049565015669	RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776
1049565015670	superoxide dismutase; Provisional; Region: PRK10925
1049565015671	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1049565015672	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1049565015673	6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536
1049565015674	MOSC domain; Region: MOSC; pfam03473
1049565015675	3-alpha domain; Region: 3-alpha; pfam03475
1049565015676	two-component sensor protein; Provisional; Region: cpxA; PRK09470
1049565015677	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1049565015678	dimerization interface [polypeptide binding]; other site
1049565015679	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1049565015680	dimer interface [polypeptide binding]; other site
1049565015681	phosphorylation site [posttranslational modification]
1049565015682	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1049565015683	ATP binding site [chemical binding]; other site
1049565015684	Mg2+ binding site [ion binding]; other site
1049565015685	G-X-G motif; other site
1049565015686	DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955
1049565015687	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1049565015688	active site
1049565015689	phosphorylation site [posttranslational modification]
1049565015690	intermolecular recognition site; other site
1049565015691	dimerization interface [polypeptide binding]; other site
1049565015692	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1049565015693	DNA binding site [nucleotide binding]
1049565015694	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
1049565015695	dimer interface [polypeptide binding]; other site
1049565015696	ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509
1049565015697	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1049565015698	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
1049565015699	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
1049565015700	active site
1049565015701	ADP/pyrophosphate binding site [chemical binding]; other site
1049565015702	dimerization interface [polypeptide binding]; other site
1049565015703	allosteric effector site; other site
1049565015704	fructose-1,6-bisphosphate binding site; other site
1049565015705	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
1049565015706	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
1049565015707	UbiA prenyltransferase family; Region: UbiA; pfam01040
1049565015708	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
1049565015709	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1049565015710	Walker A motif; other site
1049565015711	ATP binding site [chemical binding]; other site
1049565015712	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
1049565015713	Walker B motif; other site
1049565015714	arginine finger; other site
1049565015715	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1049565015716	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
1049565015717	active site
1049565015718	HslU subunit interaction site [polypeptide binding]; other site
1049565015719	essential cell division protein FtsN; Provisional; Region: PRK10927
1049565015720	cell division protein FtsN; Provisional; Region: PRK12757
1049565015721	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1049565015722	DNA binding site [nucleotide binding]
1049565015723	DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041
1049565015724	domain linker motif; other site
1049565015725	Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284
1049565015726	dimerization interface [polypeptide binding]; other site
1049565015727	ligand binding site [chemical binding]; other site
1049565015728	primosome assembly protein PriA; Validated; Region: PRK05580
1049565015729	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1049565015730	ATP binding site [chemical binding]; other site
1049565015731	putative Mg++ binding site [ion binding]; other site
1049565015732	helicase superfamily c-terminal domain; Region: HELICc; smart00490
1049565015733	ATP-binding site [chemical binding]; other site
1049565015734	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
1049565015735	Met Repressor, MetJ.  MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490
1049565015736	dimerization interface [polypeptide binding]; other site
1049565015737	DNA binding site [nucleotide binding]
1049565015738	corepressor binding sites; other site
1049565015739	cystathionine gamma-synthase; Provisional; Region: PRK08045
1049565015740	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1049565015741	homodimer interface [polypeptide binding]; other site
1049565015742	substrate-cofactor binding pocket; other site
1049565015743	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565015744	catalytic residue [active]
1049565015745	bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466
1049565015746	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
1049565015747	putative catalytic residues [active]
1049565015748	putative nucleotide binding site [chemical binding]; other site
1049565015749	putative aspartate binding site [chemical binding]; other site
1049565015750	ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892
1049565015751	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1049565015752	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1049565015753	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1049565015754	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
1049565015755	active site
1049565015756	metal binding site [ion binding]; metal-binding site
1049565015757	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1049565015758	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
1049565015759	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
1049565015760	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565015761	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
1049565015762	dimerization interface [polypeptide binding]; other site
1049565015763	substrate binding pocket [chemical binding]; other site
1049565015764	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
1049565015765	FAD binding site [chemical binding]; other site
1049565015766	EamA-like transporter family; Region: EamA; pfam00892
1049565015767	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1049565015768	EamA-like transporter family; Region: EamA; pfam00892
1049565015769	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
1049565015770	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
1049565015771	dimer interface [polypeptide binding]; other site
1049565015772	active site
1049565015773	metal binding site [ion binding]; metal-binding site
1049565015774	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
1049565015775	active site
1049565015776	intersubunit interactions; other site
1049565015777	catalytic residue [active]
1049565015778	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1049565015779	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1049565015780	zinc/cadmium-binding protein; Provisional; Region: PRK10306
1049565015781	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
1049565015782	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
1049565015783	acetylornithine deacetylase; Provisional; Region: PRK05111
1049565015784	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
1049565015785	metal binding site [ion binding]; metal-binding site
1049565015786	putative dimer interface [polypeptide binding]; other site
1049565015787	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
1049565015788	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1049565015789	AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249
1049565015790	nucleotide binding site [chemical binding]; other site
1049565015791	N-acetyl-L-glutamate binding site [chemical binding]; other site
1049565015792	argininosuccinate lyase; Provisional; Region: PRK04833
1049565015793	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1049565015794	active sites [active]
1049565015795	tetramer interface [polypeptide binding]; other site
1049565015796	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
1049565015797	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565015798	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
1049565015799	dimerization interface [polypeptide binding]; other site
1049565015800	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
1049565015801	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1049565015802	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1049565015803	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
1049565015804	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1049565015805	hypothetical protein; Provisional; Region: PRK11056
1049565015806	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
1049565015807	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1049565015808	S-adenosylmethionine binding site [chemical binding]; other site
1049565015809	vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641
1049565015810	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1049565015811	N-terminal plug; other site
1049565015812	ligand-binding site [chemical binding]; other site
1049565015813	glutamate racemase; Provisional; Region: PRK00865
1049565015814	transcriptional regulator HdfR; Provisional; Region: PRK03601
1049565015815	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565015816	LysR substrate binding domain; Region: LysR_substrate; pfam03466
1049565015817	hypothetical protein; Provisional; Region: PRK11027
1049565015818	putative ATP-dependent protease; Provisional; Region: PRK09862
1049565015819	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1049565015820	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1049565015821	Walker A motif; other site
1049565015822	ATP binding site [chemical binding]; other site
1049565015823	Walker B motif; other site
1049565015824	arginine finger; other site
1049565015825	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
1049565015826	acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978
1049565015827	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1049565015828	PYR/PP interface [polypeptide binding]; other site
1049565015829	dimer interface [polypeptide binding]; other site
1049565015830	TPP binding site [chemical binding]; other site
1049565015831	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1049565015832	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1049565015833	TPP-binding site [chemical binding]; other site
1049565015834	dimer interface [polypeptide binding]; other site
1049565015835	acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152
1049565015836	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1049565015837	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1049565015838	homodimer interface [polypeptide binding]; other site
1049565015839	substrate-cofactor binding pocket; other site
1049565015840	catalytic residue [active]
1049565015841	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
1049565015842	threonine dehydratase; Reviewed; Region: PRK09224
1049565015843	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1049565015844	tetramer interface [polypeptide binding]; other site
1049565015845	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565015846	catalytic residue [active]
1049565015847	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
1049565015848	putative Ile/Val binding site [chemical binding]; other site
1049565015849	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
1049565015850	putative Ile/Val binding site [chemical binding]; other site
1049565015851	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565015852	DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716
1049565015853	The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430
1049565015854	putative dimerization interface [polypeptide binding]; other site
1049565015855	ketol-acid reductoisomerase; Validated; Region: PRK05225
1049565015856	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
1049565015857	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1049565015858	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1049565015859	peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441
1049565015860	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
1049565015861	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
1049565015862	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
1049565015863	ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919
1049565015864	Part of AAA domain; Region: AAA_19; pfam13245
1049565015865	Family description; Region: UvrD_C_2; pfam13538
1049565015866	Protein of unknown function (DUF554); Region: DUF554; pfam04474
1049565015867	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1049565015868	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1049565015869	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565015870	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
1049565015871	substrate binding pocket [chemical binding]; other site
1049565015872	dimerization interface [polypeptide binding]; other site
1049565015873	guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031
1049565015874	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1049565015875	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
1049565015876	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1049565015877	ATP binding site [chemical binding]; other site
1049565015878	Mg++ binding site [ion binding]; other site
1049565015879	motif III; other site
1049565015880	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1049565015881	nucleotide binding region [chemical binding]; other site
1049565015882	ATP-binding site [chemical binding]; other site
1049565015883	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1049565015884	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1049565015885	catalytic residues [active]
1049565015886	transcription termination factor Rho; Provisional; Region: rho; PRK09376
1049565015887	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
1049565015888	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
1049565015889	RNA binding site [nucleotide binding]; other site
1049565015890	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
1049565015891	multimer interface [polypeptide binding]; other site
1049565015892	Walker A motif; other site
1049565015893	ATP binding site [chemical binding]; other site
1049565015894	Walker B motif; other site
1049565015895	undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119
1049565015896	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
1049565015897	Mg++ binding site [ion binding]; other site
1049565015898	putative catalytic motif [active]
1049565015899	substrate binding site [chemical binding]; other site
1049565015900	lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638
1049565015901	Chain length determinant protein; Region: Wzz; pfam02706
1049565015902	UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
1049565015903	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
1049565015904	active site
1049565015905	homodimer interface [polypeptide binding]; other site
1049565015906	UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064
1049565015907	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1049565015908	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1049565015909	dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217
1049565015910	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1049565015911	NAD binding site [chemical binding]; other site
1049565015912	substrate binding site [chemical binding]; other site
1049565015913	homodimer interface [polypeptide binding]; other site
1049565015914	active site
1049565015915	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
1049565015916	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
1049565015917	substrate binding site; other site
1049565015918	tetramer interface; other site
1049565015919	TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975
1049565015920	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1049565015921	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1049565015922	inhibitor-cofactor binding pocket; inhibition site
1049565015923	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565015924	catalytic residue [active]
1049565015925	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1049565015926	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125
1049565015927	4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429
1049565015928	putative common antigen polymerase; Provisional; Region: PRK02975
1049565015929	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
1049565015930	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
1049565015931	putative transport protein YifK; Provisional; Region: PRK10746
1049565015932	putative protoheme IX biogenesis protein; Provisional; Region: PRK10747
1049565015933	HemY protein N-terminus; Region: HemY_N; pfam07219
1049565015934	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
1049565015935	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959
1049565015936	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
1049565015937	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1049565015938	active site
1049565015939	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
1049565015940	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
1049565015941	domain interfaces; other site
1049565015942	active site
1049565015943	Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072
1049565015944	Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633
1049565015945	Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295
1049565015946	Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503
1049565015947	putative iron binding site [ion binding]; other site
1049565015948	Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361
1049565015949	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
1049565015950	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1049565015951	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1049565015952	hypothetical protein; Provisional; Region: PRK10963
1049565015953	Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973
1049565015954	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
1049565015955	active site
1049565015956	Int/Topo IB signature motif; other site
1049565015957	flavin mononucleotide phosphatase; Provisional; Region: PRK10748
1049565015958	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1049565015959	motif II; other site
1049565015960	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
1049565015961	Part of AAA domain; Region: AAA_19; pfam13245
1049565015962	Family description; Region: UvrD_C_2; pfam13538
1049565015963	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1049565015964	Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835
1049565015965	Cl binding site [ion binding]; other site
1049565015966	oligomer interface [polypeptide binding]; other site
1049565015967	putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430
1049565015968	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
1049565015969	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1049565015970	CoenzymeA binding site [chemical binding]; other site
1049565015971	subunit interaction site [polypeptide binding]; other site
1049565015972	PHB binding site; other site
1049565015973	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541
1049565015974	dimerization interface [polypeptide binding]; other site
1049565015975	substrate binding site [chemical binding]; other site
1049565015976	active site
1049565015977	calcium binding site [ion binding]; other site
1049565015978	ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057
1049565015979	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1049565015980	ATP binding site [chemical binding]; other site
1049565015981	putative Mg++ binding site [ion binding]; other site
1049565015982	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1049565015983	nucleotide binding region [chemical binding]; other site
1049565015984	ATP-binding site [chemical binding]; other site
1049565015985	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
1049565015986	Helicase and RNase D C-terminal; Region: HRDC; smart00341
1049565015987	threonine efflux system; Provisional; Region: PRK10229
1049565015988	hypothetical protein; Provisional; Region: PRK09956
1049565015989	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
1049565015990	homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520
1049565015991	lysophospholipase L2; Provisional; Region: PRK10749
1049565015992	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1049565015993	putative hydrolase; Provisional; Region: PRK10976
1049565015994	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1049565015995	active site
1049565015996	motif I; other site
1049565015997	motif II; other site
1049565015998	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1049565015999	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1049565016000	EamA-like transporter family; Region: EamA; pfam00892
1049565016001	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
1049565016002	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1049565016003	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
1049565016004	putative dimerization interface [polypeptide binding]; other site
1049565016005	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
1049565016006	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
1049565016007	THF binding site; other site
1049565016008	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1049565016009	substrate binding site [chemical binding]; other site
1049565016010	THF binding site; other site
1049565016011	zinc-binding site [ion binding]; other site
1049565016012	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
1049565016013	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1049565016014	uridine phosphorylase; Provisional; Region: PRK11178
1049565016015	uridine phosphorylase; Region: Uridine-psphlse; TIGR01718
1049565016016	DNA recombination protein RmuC; Provisional; Region: PRK10361
1049565016017	RmuC family; Region: RmuC; pfam02646
1049565016018	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
1049565016019	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1049565016020	S-adenosylmethionine binding site [chemical binding]; other site
1049565016021	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
1049565016022	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
1049565016023	SCP-2 sterol transfer family; Region: SCP2; pfam02036
1049565016024	putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750
1049565016025	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
1049565016026	twin arginine translocase protein A; Provisional; Region: tatA; PRK03554
1049565016027	sec-independent translocase; Provisional; Region: PRK01770
1049565016028	twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921
1049565016029	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1049565016030	active site
1049565016031	N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766
1049565016032	transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014
1049565016033	3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922
1049565016034	FMN reductase; Validated; Region: fre; PRK08051
1049565016035	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
1049565016036	FAD binding pocket [chemical binding]; other site
1049565016037	FAD binding motif [chemical binding]; other site
1049565016038	phosphate binding motif [ion binding]; other site
1049565016039	beta-alpha-beta structure motif; other site
1049565016040	NAD binding pocket [chemical binding]; other site
1049565016041	3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947
1049565016042	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1049565016043	dimer interface [polypeptide binding]; other site
1049565016044	active site
1049565016045	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
1049565016046	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1049565016047	substrate binding site [chemical binding]; other site
1049565016048	oxyanion hole (OAH) forming residues; other site
1049565016049	trimer interface [polypeptide binding]; other site
1049565016050	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1049565016051	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1049565016052	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1049565016053	proline dipeptidase; Provisional; Region: PRK13607
1049565016054	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
1049565016055	active site
1049565016056	hypothetical protein; Provisional; Region: PRK11568
1049565016057	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
1049565016058	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
1049565016059	potassium transporter; Provisional; Region: PRK10750
1049565016060	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1049565016061	protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104
1049565016062	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
1049565016063	FAD binding domain; Region: FAD_binding_4; pfam01565
1049565016064	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1049565016065	Biotin operon repressor [Transcription]; Region: BirA; COG1654
1049565016066	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
1049565016067	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
1049565016068	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
1049565016069	pantothenate kinase; Provisional; Region: PRK05439
1049565016070	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
1049565016071	ATP-binding site [chemical binding]; other site
1049565016072	CoA-binding site [chemical binding]; other site
1049565016073	Mg2+-binding site [ion binding]; other site
1049565016074	elongation factor Tu; Reviewed; Region: PRK00049
1049565016075	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1049565016076	G1 box; other site
1049565016077	GEF interaction site [polypeptide binding]; other site
1049565016078	GTP/Mg2+ binding site [chemical binding]; other site
1049565016079	Switch I region; other site
1049565016080	G2 box; other site
1049565016081	G3 box; other site
1049565016082	Switch II region; other site
1049565016083	G4 box; other site
1049565016084	G5 box; other site
1049565016085	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1049565016086	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1049565016087	Antibiotic Binding Site [chemical binding]; other site
1049565016088	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
1049565016089	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1049565016090	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1049565016091	putative homodimer interface [polypeptide binding]; other site
1049565016092	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1049565016093	heterodimer interface [polypeptide binding]; other site
1049565016094	homodimer interface [polypeptide binding]; other site
1049565016095	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1049565016096	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1049565016097	23S rRNA interface [nucleotide binding]; other site
1049565016098	L7/L12 interface [polypeptide binding]; other site
1049565016099	putative thiostrepton binding site; other site
1049565016100	L25 interface [polypeptide binding]; other site
1049565016101	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1049565016102	mRNA/rRNA interface [nucleotide binding]; other site
1049565016103	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1049565016104	23S rRNA interface [nucleotide binding]; other site
1049565016105	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1049565016106	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1049565016107	core dimer interface [polypeptide binding]; other site
1049565016108	peripheral dimer interface [polypeptide binding]; other site
1049565016109	L10 interface [polypeptide binding]; other site
1049565016110	L11 interface [polypeptide binding]; other site
1049565016111	putative EF-Tu interaction site [polypeptide binding]; other site
1049565016112	putative EF-G interaction site [polypeptide binding]; other site
1049565016113	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
1049565016114	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1049565016115	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
1049565016116	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1049565016117	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
1049565016118	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1049565016119	RPB3 interaction site [polypeptide binding]; other site
1049565016120	RPB1 interaction site [polypeptide binding]; other site
1049565016121	RPB11 interaction site [polypeptide binding]; other site
1049565016122	RPB10 interaction site [polypeptide binding]; other site
1049565016123	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1049565016124	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
1049565016125	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1049565016126	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1049565016127	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1049565016128	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
1049565016129	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
1049565016130	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
1049565016131	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
1049565016132	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1049565016133	DNA binding site [nucleotide binding]
1049565016134	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1049565016135	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
1049565016136	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489
1049565016137	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
1049565016138	methionine cluster; other site
1049565016139	active site
1049565016140	phosphorylation site [posttranslational modification]
1049565016141	metal binding site [ion binding]; metal-binding site
1049565016142	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
1049565016143	active site
1049565016144	P-loop; other site
1049565016145	phosphorylation site [posttranslational modification]
1049565016146	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1049565016147	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1049565016148	metal binding site [ion binding]; metal-binding site
1049565016149	active site
1049565016150	I-site; other site
1049565016151	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
1049565016152	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1049565016153	FeS/SAM binding site; other site
1049565016154	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
1049565016155	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
1049565016156	ThiS interaction site; other site
1049565016157	putative active site [active]
1049565016158	tetramer interface [polypeptide binding]; other site
1049565016159	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
1049565016160	thiS-thiF/thiG interaction site; other site
1049565016161	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1049565016162	thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356
1049565016163	ATP binding site [chemical binding]; other site
1049565016164	substrate interface [chemical binding]; other site
1049565016165	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1049565016166	thiamine phosphate binding site [chemical binding]; other site
1049565016167	active site
1049565016168	pyrophosphate binding site [ion binding]; other site
1049565016169	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
1049565016170	ThiC-associated domain; Region: ThiC-associated; pfam13667
1049565016171	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
1049565016172	anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718
1049565016173	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
1049565016174	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
1049565016175	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
1049565016176	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
1049565016177	putative NADH binding site [chemical binding]; other site
1049565016178	putative active site [active]
1049565016179	nudix motif; other site
1049565016180	putative metal binding site [ion binding]; other site
1049565016181	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
1049565016182	substrate binding site [chemical binding]; other site
1049565016183	active site
1049565016184	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
1049565016185	Active_site [active]
1049565016186	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068
1049565016187	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1049565016188	IHF dimer interface [polypeptide binding]; other site
1049565016189	IHF - DNA interface [nucleotide binding]; other site
1049565016190	Protein of unknown function (DUF1481); Region: DUF1481; pfam07356
1049565016191	zinc resistance protein; Provisional; Region: zraP; PRK11546
1049565016192	dimer interface [polypeptide binding]; other site
1049565016193	sensor protein ZraS; Provisional; Region: PRK10364
1049565016194	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1049565016195	dimer interface [polypeptide binding]; other site
1049565016196	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1049565016197	ATP binding site [chemical binding]; other site
1049565016198	Mg2+ binding site [ion binding]; other site
1049565016199	G-X-G motif; other site
1049565016200	transcriptional regulatory protein ZraR; Provisional; Region: PRK10365
1049565016201	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1049565016202	active site
1049565016203	phosphorylation site [posttranslational modification]
1049565016204	intermolecular recognition site; other site
1049565016205	dimerization interface [polypeptide binding]; other site
1049565016206	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1049565016207	Walker A motif; other site
1049565016208	ATP binding site [chemical binding]; other site
1049565016209	Walker B motif; other site
1049565016210	arginine finger; other site
1049565016211	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1049565016212	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
1049565016213	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1049565016214	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
1049565016215	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1049565016216	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
1049565016217	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1049565016218	purine monophosphate binding site [chemical binding]; other site
1049565016219	dimer interface [polypeptide binding]; other site
1049565016220	putative catalytic residues [active]
1049565016221	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
1049565016222	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
1049565016223	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901
1049565016224	Cupin; Region: Cupin_6; pfam12852
1049565016225	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
1049565016226	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1049565016227	putative NAD(P) binding site [chemical binding]; other site
1049565016228	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1049565016229	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1049565016230	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1049565016231	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1049565016232	EamA-like transporter family; Region: EamA; pfam00892
1049565016233	EamA-like transporter family; Region: EamA; pfam00892
1049565016234	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1049565016235	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1049565016236	putative DNA binding site [nucleotide binding]; other site
1049565016237	putative Zn2+ binding site [ion binding]; other site
1049565016238	AsnC family; Region: AsnC_trans_reg; pfam01037
1049565016239	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
1049565016240	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
1049565016241	Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; pfam10137
1049565016242	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
1049565016243	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
1049565016244	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
1049565016245	oligomeric interface; other site
1049565016246	putative active site [active]
1049565016247	homodimer interface [polypeptide binding]; other site
1049565016248	Transposase; Region: HTH_Tnp_1; cl17663
1049565016249	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1049565016250	Restriction endonuclease; Region: Mrr_cat; pfam04471
1049565016251	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
1049565016252	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
1049565016253	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
1049565016254	Electron transfer DM13; Region: DM13; pfam10517
1049565016255	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1049565016256	Protein of unknown function, DUF417; Region: DUF417; cl01162
1049565016257	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1049565016258	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1049565016259	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
1049565016260	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1049565016261	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1049565016262	N-terminal plug; other site
1049565016263	ligand-binding site [chemical binding]; other site
1049565016264	Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486
1049565016265	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1049565016266	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
1049565016267	IucA / IucC family; Region: IucA_IucC; pfam04183
1049565016268	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1049565016269	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
1049565016270	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
1049565016271	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
1049565016272	IucA / IucC family; Region: IucA_IucC; pfam04183
1049565016273	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1049565016274	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1049565016275	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
1049565016276	DDE superfamily endonuclease; Region: DDE_3; pfam13358
1049565016277	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1049565016278	active site
1049565016279	catalytic residues [active]
1049565016280	metal binding site [ion binding]; metal-binding site
1049565016281	fec operon regulator FecR; Reviewed; Region: PRK09774
1049565016282	lysozyme inhibitor; Provisional; Region: PRK13791
1049565016283	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
1049565016284	putative DNA binding helix; other site
1049565016285	metal binding site 2 [ion binding]; metal-binding site
1049565016286	metal binding site 1 [ion binding]; metal-binding site
1049565016287	structural Zn2+ binding site [ion binding]; other site
1049565016288	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1049565016289	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1049565016290	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1049565016291	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1049565016292	S-adenosylmethionine binding site [chemical binding]; other site
1049565016293	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1049565016294	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1049565016295	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1049565016296	ABC-ATPase subunit  interface; other site
1049565016297	dimer interface [polypeptide binding]; other site
1049565016298	putative PBP binding regions; other site
1049565016299	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
1049565016300	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
1049565016301	putative ligand binding residues [chemical binding]; other site
1049565016302	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1049565016303	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1049565016304	Walker A/P-loop; other site
1049565016305	ATP binding site [chemical binding]; other site
1049565016306	Q-loop/lid; other site
1049565016307	ABC transporter signature motif; other site
1049565016308	Walker B; other site
1049565016309	D-loop; other site
1049565016310	H-loop/switch region; other site
1049565016311	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
1049565016312	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1049565016313	Uncharacterized conserved protein [Function unknown]; Region: COG5464
1049565016314	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
1049565016315	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1049565016316	active site
1049565016317	catalytic residues [active]
1049565016318	DNA binding site [nucleotide binding]
1049565016319	Int/Topo IB signature motif; other site
1049565016320	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1049565016321	GAF domain; Region: GAF; pfam01590
1049565016322	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1049565016323	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1049565016324	metal binding site [ion binding]; metal-binding site
1049565016325	active site
1049565016326	I-site; other site
1049565016327	Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183
1049565016328	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1049565016329	active site
1049565016330	Domain of unknown function (DUF305); Region: DUF305; cl17794
1049565016331	sensor kinase CusS; Provisional; Region: PRK09835
1049565016332	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1049565016333	dimerization interface [polypeptide binding]; other site
1049565016334	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1049565016335	dimer interface [polypeptide binding]; other site
1049565016336	phosphorylation site [posttranslational modification]
1049565016337	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1049565016338	ATP binding site [chemical binding]; other site
1049565016339	Mg2+ binding site [ion binding]; other site
1049565016340	G-X-G motif; other site
1049565016341	DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836
1049565016342	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1049565016343	active site
1049565016344	phosphorylation site [posttranslational modification]
1049565016345	intermolecular recognition site; other site
1049565016346	dimerization interface [polypeptide binding]; other site
1049565016347	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1049565016348	DNA binding site [nucleotide binding]
1049565016349	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
1049565016350	periplasmic copper-binding protein; Provisional; Region: PRK09838
1049565016351	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
1049565016352	HlyD family secretion protein; Region: HlyD_3; pfam13437
1049565016353	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
1049565016354	Protein of unknown function, DUF; Region: DUF411; cl01142
1049565016355	YHS domain; Region: YHS; pfam04945
1049565016356	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
1049565016357	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1049565016358	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1049565016359	motif II; other site
1049565016360	Protein of unknown function (DUF2933); Region: DUF2933; pfam11666
1049565016361	Peptidase family M23; Region: Peptidase_M23; pfam01551
1049565016362	potential frameshift: common BLAST hit: gi|168998678|ref|YP_001687946.1| copper resistant protein PcoA
1049565016363	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
1049565016364	CopC domain; Region: CopC; pfam04234
1049565016365	Copper resistance protein D; Region: CopD; cl00563
1049565016366	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
1049565016367	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1049565016368	active site
1049565016369	phosphorylation site [posttranslational modification]
1049565016370	intermolecular recognition site; other site
1049565016371	dimerization interface [polypeptide binding]; other site
1049565016372	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1049565016373	DNA binding site [nucleotide binding]
1049565016374	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
1049565016375	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1049565016376	dimerization interface [polypeptide binding]; other site
1049565016377	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1049565016378	dimer interface [polypeptide binding]; other site
1049565016379	phosphorylation site [posttranslational modification]
1049565016380	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1049565016381	ATP binding site [chemical binding]; other site
1049565016382	Mg2+ binding site [ion binding]; other site
1049565016383	G-X-G motif; other site
1049565016384	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
1049565016385	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
1049565016386	DNA binding residues [nucleotide binding]
1049565016387	dimer interface [polypeptide binding]; other site
1049565016388	putative metal binding site [ion binding]; other site
1049565016389	Heavy-metal-associated domain; Region: HMA; pfam00403
1049565016390	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1049565016391	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
1049565016392	metal-binding site [ion binding]
1049565016393	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1049565016394	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1049565016395	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
1049565016396	active site
1049565016397	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
1049565016398	lipoprotein signal peptidase; Provisional; Region: PRK14787
1049565016399	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1049565016400	multiple promoter invertase; Provisional; Region: mpi; PRK13413
1049565016401	catalytic residues [active]
1049565016402	catalytic nucleophile [active]
1049565016403	Presynaptic Site I dimer interface [polypeptide binding]; other site
1049565016404	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1049565016405	Synaptic Flat tetramer interface [polypeptide binding]; other site
1049565016406	Synaptic Site I dimer interface [polypeptide binding]; other site
1049565016407	DNA binding site [nucleotide binding]
1049565016408	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
1049565016409	DNA-binding interface [nucleotide binding]; DNA binding site
1049565016410	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
1049565016411	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
1049565016412	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
1049565016413	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
1049565016414	IS2 repressor TnpA; Reviewed; Region: PRK09413
1049565016415	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1049565016416	HTH-like domain; Region: HTH_21; pfam13276
1049565016417	Integrase core domain; Region: rve; pfam00665
1049565016418	Integrase core domain; Region: rve_3; pfam13683
1049565016419	Integrase core domain; Region: rve; pfam00665
1049565016420	Integrase core domain; Region: rve_2; pfam13333
1049565016421	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
1049565016422	dimer interface [polypeptide binding]; other site
1049565016423	allosteric magnesium binding site [ion binding]; other site
1049565016424	active site
1049565016425	aspartate-rich active site metal binding site; other site
1049565016426	Schiff base residues; other site
1049565016427	dihydroorotase; Reviewed; Region: PRK09236
1049565016428	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1049565016429	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
1049565016430	active site
1049565016431	Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_4; cd06231
1049565016432	putative active site [active]
1049565016433	Zn binding site [ion binding]; other site
1049565016434	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
1049565016435	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1049565016436	active site
1049565016437	motif 3; other site
1049565016438	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1049565016439	anticodon binding site; other site
1049565016440	Protein of unknown function (DUF1460); Region: DUF1460; pfam07313
1049565016441	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
1049565016442	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
1049565016443	Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710
1049565016444	trimer interface [polypeptide binding]; other site
1049565016445	active site
1049565016446	putative GTP cyclohydrolase; Provisional; Region: PRK13674
1049565016447	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
1049565016448	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1049565016449	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1049565016450	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1049565016451	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
1049565016452	tRNA synthetases class I (C) catalytic domain; Region: tRNA-synt_1e; pfam01406
1049565016453	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1049565016454	active site
1049565016455	HIGH motif; other site
1049565016456	nucleotide binding site [chemical binding]; other site
1049565016457	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1049565016458	KMSKS motif; other site
1049565016459	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1049565016460	tRNA binding surface [nucleotide binding]; other site
1049565016461	anticodon binding site; other site
1049565016462	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1049565016463	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1049565016464	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1049565016465	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1049565016466	G1 box; other site
1049565016467	GTP/Mg2+ binding site [chemical binding]; other site
1049565016468	ferrous iron transporter FeoB; Region: feoB; TIGR00437
1049565016469	G2 box; other site
1049565016470	Switch I region; other site
1049565016471	G3 box; other site
1049565016472	Switch II region; other site
1049565016473	G4 box; other site
1049565016474	G5 box; other site
1049565016475	Nucleoside recognition; Region: Gate; pfam07670
1049565016476	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1049565016477	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1049565016478	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1049565016479	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
1049565016480	Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735
1049565016481	metal binding site 2 [ion binding]; metal-binding site
1049565016482	putative DNA binding helix; other site
1049565016483	metal binding site 1 [ion binding]; metal-binding site
1049565016484	dimer interface [polypeptide binding]; other site
1049565016485	structural Zn2+ binding site [ion binding]; other site
1049565016486	Homeodomain-like domain; Region: HTH_23; pfam13384
1049565016487	Winged helix-turn helix; Region: HTH_29; pfam13551
1049565016488	Homeodomain-like domain; Region: HTH_32; pfam13565
1049565016489	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1049565016490	metal binding site [ion binding]; metal-binding site
1049565016491	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1049565016492	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1049565016493	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1049565016494	Walker A/P-loop; other site
1049565016495	ATP binding site [chemical binding]; other site
1049565016496	Q-loop/lid; other site
1049565016497	ABC transporter signature motif; other site
1049565016498	Walker B; other site
1049565016499	D-loop; other site
1049565016500	H-loop/switch region; other site
1049565016501	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1049565016502	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1049565016503	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1049565016504	Walker A/P-loop; other site
1049565016505	ATP binding site [chemical binding]; other site
1049565016506	Q-loop/lid; other site
1049565016507	ABC transporter signature motif; other site
1049565016508	Walker B; other site
1049565016509	D-loop; other site
1049565016510	H-loop/switch region; other site
1049565016511	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1049565016512	putative substrate translocation pore; other site
1049565016513	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490
1049565016514	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1049565016515	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1049565016516	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1049565016517	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1049565016518	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901
1049565016519	Uncharacterized conserved protein [Function unknown]; Region: COG4925
1049565016520	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1049565016521	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1049565016522	active site
1049565016523	catalytic tetrad [active]
1049565016524	global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947
1049565016525	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
1049565016526	Staphylococcal nuclease homologues; Region: SNc; smart00318
1049565016527	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
1049565016528	Catalytic site; other site
1049565016529	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
1049565016530	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
1049565016531	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
1049565016532	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
1049565016533	Domain of unknown function (DUF4400); Region: DUF4400; cl14023
1049565016534	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
1049565016535	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
1049565016536	tandem repeat interface [polypeptide binding]; other site
1049565016537	oligomer interface [polypeptide binding]; other site
1049565016538	active site residues [active]
1049565016539	Nuclease-related domain; Region: NERD; pfam08378
1049565016540	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
1049565016541	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1049565016542	EcsC protein family; Region: EcsC; pfam12787
1049565016543	Protein of unknown function (DUF2971); Region: DUF2971; pfam11185
1049565016544	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
1049565016545	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1049565016546	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
1049565016547	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1049565016548	acyl-activating enzyme (AAE) consensus motif; other site
1049565016549	AMP binding site [chemical binding]; other site
1049565016550	active site
1049565016551	CoA binding site [chemical binding]; other site
1049565016552	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
1049565016553	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1049565016554	MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042
1049565016555	AIR synthase-related protein, sll0787 family; Region: AIR_rel_sll0787; TIGR04049
1049565016556	AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192
1049565016557	dimerization interface [polypeptide binding]; other site
1049565016558	putative ATP binding site [chemical binding]; other site
1049565016559	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1049565016560	Coenzyme A binding pocket [chemical binding]; other site
1049565016561	radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043
1049565016562	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1049565016563	FeS/SAM binding site; other site
1049565016564	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
1049565016565	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1049565016566	putative active site [active]
1049565016567	catalytic triad [active]
1049565016568	putative dimer interface [polypeptide binding]; other site
1049565016569	MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044
1049565016570	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1049565016571	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1049565016572	DNA-binding site [nucleotide binding]; DNA binding site
1049565016573	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1049565016574	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1049565016575	homodimer interface [polypeptide binding]; other site
1049565016576	catalytic residue [active]
1049565016577	Haemolysin expression modulating protein; Region: HHA; cl11501
1049565016578	Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799
1049565016579	DNA binding site [nucleotide binding]
1049565016580	dimer interface [polypeptide binding]; other site
1049565016581	active site
1049565016582	Int/Topo IB signature motif; other site
1049565016583	DNA replication terminus site-binding protein (Ter protein); Region: Ter; cl11502
1049565016584	IS2 transposase TnpB; Reviewed; Region: PRK09409
1049565016585	HTH-like domain; Region: HTH_21; pfam13276
1049565016586	Integrase core domain; Region: rve; pfam00665
1049565016587	Integrase core domain; Region: rve_3; pfam13683
1049565016588	Transposase; Region: HTH_Tnp_1; cl17663
1049565016589	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1049565016590	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1049565016591	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1049565016592	Transposase; Region: HTH_Tnp_1; cl17663
1049565016593	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1049565016594	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
1049565016595	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1049565016596	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
1049565016597	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1049565016598	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
1049565016599	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1049565016600	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
1049565016601	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1049565016602	Transposase; Region: HTH_Tnp_1; pfam01527
1049565016603	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
1049565016604	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
1049565016605	ParB-like nuclease domain; Region: ParB; smart00470
1049565016606	plasmid-partitioning protein SopA; Provisional; Region: PRK13705
1049565016607	MerR family regulatory protein; Region: MerR; pfam00376
1049565016608	DNA binding residues [nucleotide binding]
1049565016609	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1049565016610	P-loop; other site
1049565016611	Magnesium ion binding site [ion binding]; other site
1049565016612	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1049565016613	Magnesium ion binding site [ion binding]; other site
1049565016614	Initiator Replication protein; Region: Rep_3; pfam01051
1049565016615	potential frameshift: common BLAST hit: gi|324120112|ref|YP_004249873.1| integrase
1049565016616	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
1049565016617	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1049565016618	Integrase core domain; Region: rve; pfam00665
1049565016619	Integrase core domain; Region: rve_3; pfam13683
1049565016620	Transposase; Region: HTH_Tnp_1; cl17663
1049565016621	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1049565016622	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
1049565016623	KorB domain; Region: KorB; pfam08535
1049565016624	DNA-binding interface [nucleotide binding]; DNA binding site
1049565016625	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1049565016626	Integrase core domain; Region: rve; pfam00665
1049565016627	transposase/IS protein; Provisional; Region: PRK09183
1049565016628	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1049565016629	Walker A motif; other site
1049565016630	ATP binding site [chemical binding]; other site
1049565016631	Walker B motif; other site
1049565016632	HTH-like domain; Region: HTH_21; pfam13276
1049565016633	Transposase; Region: HTH_Tnp_1; pfam01527
1049565016634	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
1049565016635	KorB domain; Region: KorB; pfam08535
1049565016636	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1049565016637	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1049565016638	P-loop; other site
1049565016639	Magnesium ion binding site [ion binding]; other site
1049565016640	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1049565016641	Magnesium ion binding site [ion binding]; other site
1049565016642	DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684
1049565016643	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1049565016644	Zn binding sites [ion binding]; other site
1049565016645	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
1049565016646	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1049565016647	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1049565016648	AAA domain; Region: AAA_22; pfam13401
1049565016649	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1049565016650	Walker A/P-loop; other site
1049565016651	ATP binding site [chemical binding]; other site
1049565016652	CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cl08497
1049565016653	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
1049565016654	BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in...; Region: BAH; cl02608
1049565016655	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
1049565016656	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
1049565016657	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
1049565016658	Integrase core domain; Region: rve; pfam00665
1049565016659	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
1049565016660	DNA binding residues [nucleotide binding]
1049565016661	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1049565016662	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1049565016663	DNA binding residues [nucleotide binding]
1049565016664	dimerization interface [polypeptide binding]; other site
1049565016665	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1049565016666	EamA-like transporter family; Region: EamA; pfam00892
1049565016667	EamA-like transporter family; Region: EamA; pfam00892
1049565016668	outer membrane receptor FepA; Provisional; Region: PRK13528
1049565016669	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1049565016670	N-terminal plug; other site
1049565016671	ligand-binding site [chemical binding]; other site
1049565016672	Domain of unknown function (DUF3327); Region: DUF3327; pfam11806
1049565016673	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
1049565016674	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1049565016675	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1049565016676	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1049565016677	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1049565016678	Walker A/P-loop; other site
1049565016679	ATP binding site [chemical binding]; other site
1049565016680	Q-loop/lid; other site
1049565016681	ABC transporter signature motif; other site
1049565016682	Walker B; other site
1049565016683	D-loop; other site
1049565016684	H-loop/switch region; other site
1049565016685	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1049565016686	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1049565016687	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1049565016688	Walker A/P-loop; other site
1049565016689	ATP binding site [chemical binding]; other site
1049565016690	Q-loop/lid; other site
1049565016691	ABC transporter signature motif; other site
1049565016692	Walker B; other site
1049565016693	D-loop; other site
1049565016694	H-loop/switch region; other site
1049565016695	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
1049565016696	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
1049565016697	homodimer interface [polypeptide binding]; other site
1049565016698	active site
1049565016699	TDP-binding site; other site
1049565016700	acceptor substrate-binding pocket; other site
1049565016701	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
1049565016702	ParB-like nuclease domain; Region: ParB; smart00470
1049565016703	Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969
1049565016704	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1049565016705	Active Sites [active]
1049565016706	Domain of unknown function (DUF3440); Region: DUF3440; pfam11922
1049565016707	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1049565016708	Integrase core domain; Region: rve_2; pfam13333
1049565016709	RNA polymerase sigma factor FecI; Provisional; Region: PRK09651
1049565016710	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1049565016711	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1049565016712	FecR protein; Region: FecR; pfam04773
1049565016713	Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772
1049565016714	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1049565016715	N-terminal plug; other site
1049565016716	ligand-binding site [chemical binding]; other site
1049565016717	iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411
1049565016718	Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954
1049565016719	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
1049565016720	Protein of unknown function (DUF2384); Region: DUF2384; cl17718
1049565016721	putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293
1049565016722	RES domain; Region: RES; pfam08808